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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Drug-Induced Dyskinesia
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Accession:DOID:9008394 term browser browse the term
Definition:Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)
Synonyms:exact_synonym: Drug-Induced Dyskinesias;   Medication Induced Dyskinesia;   Medication-Induced Dyskinesias
 primary_id: MESH:D004409
 xref: EFO:1000904



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Drug-Induced Dyskinesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase ISO RGD PMID:7740056 PMID:6445277 RGD:1598524, RGD:10047091 NCBI chr16:8,331,293...8,439,432
Ensembl chr16:8,331,293...8,439,432
JBrowse link
G Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit ISO RGD PMID:18947822 RGD:6906919 NCBI chr14:29,761,898...30,213,113
Ensembl chr14:29,761,896...30,213,412
JBrowse link
G Cat catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19109989 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cck cholecystokinin ISO CTD Direct Evidence: therapeutic CTD PMID:2320253 NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760
JBrowse link
G Comt catechol-O-methyltransferase ISO RGD PMID:16437585 RGD:2289781 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 ISO RGD PMID:12629505 RGD:1358549 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
G Dbn1 drebrin 1 ISO levodopainduced; protein:increased expression:striatum: RGD PMID:23241013 RGD:10398811 NCBI chr13:55,621,241...55,635,874
Ensembl chr13:55,621,242...55,635,924
JBrowse link
G Ddc dopa decarboxylase ISO associated with Parkinson Disease; protein:decreased expression:striatum (rat) RGD PMID:20232137 RGD:5128860 NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144
JBrowse link
G Drd1 dopamine receptor D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7845605 PMID:10858612 PMID:16982285 PMID:19520364 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
JBrowse link
G Drd2 dopamine receptor D2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:7845605 PMID:10534246 PMID:14629710 PMID:18707801 RGD:2311579 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
JBrowse link
G Drd3 dopamine receptor D3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20945430 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295
JBrowse link
G Egr1 early growth response 1 ISO RGD PMID:22153973 RGD:10395307 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
JBrowse link
G Fosb FBJ osteosarcoma oncogene B ISO CTD Direct Evidence: marker/mechanism CTD PMID:17219962 NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976
JBrowse link
G Gad1 glutamate decarboxylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9767399 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358
JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:15659429 NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870
JBrowse link
G Gdnf glial cell line derived neurotrophic factor ISO CTD Direct Evidence: therapeutic CTD PMID:11168568 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056
JBrowse link
G Glul glutamate-ammonia ligase ISO RGD PMID:6445277 RGD:10047091 NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO associated with Parkinson Disease RGD PMID:20410529 RGD:5684919 NCBI chr13:55,592,865...55,608,740
Ensembl chr13:55,592,885...55,608,740
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment ISO associated with Parkinsonian Disorders RGD PMID:26997328 RGD:13792768 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Homer1 homer scaffolding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24126708 NCBI chr13:93,440,265...93,549,471
Ensembl chr13:93,436,143...93,541,637
JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A ISO RGD PMID:21352823 RGD:5683628 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630
JBrowse link
G Mapt microtubule-associated protein tau treatment ISO associated with Parkinsonian Disorders RGD PMID:25511986 RGD:13800920 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment ISO associated with Parkinsonian Disorders RGD PMID:23938307 RGD:10040953 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Pdyn prodynorphin severity
treatment
ISO CTD Direct Evidence: marker/mechanism
associated with Parkinsonism;protein:increased expression:striatum
CTD
RGD
PMID:9767399 PMID:21737418 PMID:21737418 PMID:17884291 PMID:10869049 RGD:401850563, RGD:401851046, RGD:401900134 NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764
JBrowse link
G Penk preproenkephalin disease_progression
treatment
ISO mRNA:increased expression:brain:striatum:
CTD Direct Evidence: marker/mechanism
associated with Parkinsonism;mRNA:increased expression:striatum
CTD
RGD
PMID:9767399 PMID:20456008 PMID:26113400 PMID:10869049 RGD:10003039, RGD:401851054, RGD:401900134 NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory inhibitor subunit 1B treatment ISO associated with Parkinsonian Disorders RGD PMID:27771532 RGD:13514053 NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622
JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:21115823 NCBI chr 9:89,791,565...89,909,032
Ensembl chr 9:89,791,961...89,909,030
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) ISO protein:increased expression:nucleus, brain RGD PMID:18590723 RGD:2298778 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Rgs4 regulator of G-protein signaling 4 treatment ISO associated with Parkinsonian Disorders RGD PMID:24969021 RGD:13524515 NCBI chr 1:169,569,046...169,575,211
Ensembl chr 1:169,569,046...169,575,211
JBrowse link
G Rgs9 regulator of G-protein signaling 9 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:18160641 PMID:24663062 NCBI chr11:109,116,174...109,189,013
Ensembl chr11:109,116,181...109,188,955
JBrowse link
G Th tyrosine hydroxylase ISO CTD Direct Evidence: therapeutic CTD PMID:15659429 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
JBrowse link
Tardive Dyskinesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 treatment ISO associated with schizophrenia RGD PMID:10889552 RGD:1358545 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Drd3 dopamine receptor D3 ISO associated with schizophrenia RGD PMID:12960753 RGD:1581250 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO associated with schizophrenia RGD PMID:12960753 RGD:1581250 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16271
    syndrome 10874
      toxic encephalopathy 208
        Drug-Induced Dyskinesia 33
          Tardive Dyskinesia 3
Path 2
Term Annotations click to browse term
  disease 16271
    disease of anatomical entity 15862
      nervous system disease 13796
        central nervous system disease 12314
          brain disease 11556
            movement disease 2613
              Dyskinesias 2219
                Drug-Induced Dyskinesia 33
                  Tardive Dyskinesia 3
paths to the root