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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Drug-Induced Dyskinesia
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Accession:DOID:9008394 term browser browse the term
Definition:Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)
Synonyms:exact_synonym: Drug-Induced Dyskinesias;   Medication Induced Dyskinesia;   Medication-Induced Dyskinesias
 primary_id: MESH:D004409
 xref: EFO:1000904



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Drug-Induced Dyskinesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABAT 4-aminobutyrate aminotransferase ISO RGD PMID:7740056 PMID:6445277 RGD:1598524, RGD:10047091 NCBI chr16:8,674,617...8,784,570
Ensembl chr16:8,674,596...8,784,575
JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:18947822 RGD:6906919 NCBI chr 3:53,494,611...53,813,733
Ensembl chr 3:53,328,963...53,813,733
JBrowse link
G CAT catalase EXP CTD Direct Evidence: marker/mechanism CTD PMID:19109989 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCK cholecystokinin EXP CTD Direct Evidence: therapeutic CTD PMID:2320253 NCBI chr 3:42,257,826...42,266,185
Ensembl chr 3:42,257,825...42,266,185
JBrowse link
G COMT catechol-O-methyltransferase ISO RGD PMID:16437585 RGD:2289781 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) IAGP RGD PMID:12629505 RGD:1358549 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
JBrowse link
G DBN1 drebrin 1 ISO levodopainduced; protein:increased expression:striatum: RGD PMID:23241013 RGD:10398811 NCBI chr 5:177,456,610...177,473,634
Ensembl chr 5:177,456,608...177,474,401
JBrowse link
G DDC dopa decarboxylase ISO associated with Parkinson Disease; protein:decreased expression:striatum (rat) RGD PMID:20232137 RGD:5128860 NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405
JBrowse link
G DRD1 dopamine receptor D1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:7845605 PMID:10858612 PMID:16982285 PMID:19520364 NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182
JBrowse link
G DRD2 dopamine receptor D2 ISO
EXP
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:7845605 PMID:10534246 PMID:14629710 PMID:18707801 RGD:2311579 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G DRD3 dopamine receptor D3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20945430 NCBI chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407
JBrowse link
G EGR1 early growth response 1 ISO RGD PMID:22153973 RGD:10395307 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:17219962 NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179
JBrowse link
G GAD1 glutamate decarboxylase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:9767399 NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151
JBrowse link
G GCH1 GTP cyclohydrolase 1 EXP CTD Direct Evidence: therapeutic CTD PMID:15659429 NCBI chr14:54,842,017...54,902,826
Ensembl chr14:54,842,008...54,902,826
JBrowse link
G GDNF glial cell derived neurotrophic factor EXP CTD Direct Evidence: therapeutic CTD PMID:11168568 NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041
JBrowse link
G GLUL glutamate-ammonia ligase ISO RGD PMID:6445277 RGD:10047091 NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,378,098...182,392,206
JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO associated with Parkinson Disease RGD PMID:20410529 RGD:5684919 NCBI chr 5:177,425,523...177,442,891
Ensembl chr 5:177,403,204...177,442,901
JBrowse link
G GSK3B glycogen synthase kinase 3 beta treatment ISO associated with Parkinsonian Disorders RGD PMID:26997328 RGD:13792768 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G HOMER1 homer scaffold protein 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24126708 NCBI chr 5:79,372,636...79,514,134
Ensembl chr 5:79,372,636...79,514,134
JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A ISO RGD PMID:21352823 RGD:5683628 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507
JBrowse link
G MAPT microtubule associated protein tau treatment ISO associated with Parkinsonian Disorders RGD PMID:25511986 RGD:13800920 NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334
JBrowse link
G MTOR mechanistic target of rapamycin kinase treatment ISO associated with Parkinsonian Disorders RGD PMID:23938307 RGD:10040953 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556
JBrowse link
G PDYN prodynorphin treatment
severity
EXP
ISO
CTD Direct Evidence: marker/mechanism
associated with Parkinsonism
associated with Parkinsonism;protein:increased expression:striatum
CTD
RGD
PMID:9767399 PMID:21737418 PMID:10869049 PMID:17884291 PMID:21737418 RGD:401900134, RGD:401851046, RGD:401850563 NCBI chr20:1,978,756...1,994,285
Ensembl chr20:1,978,757...1,994,285
JBrowse link
G PENK proenkephalin treatment
disease_progression
ISO
EXP
mRNA:increased expression:brain:striatum:
associated with Parkinsonism
associated with Parkinsonism;mRNA:increased expression:striatum
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:9767399 PMID:20456008 PMID:10869049 PMID:26113400 RGD:10003039, RGD:401900134, RGD:401851054 NCBI chr 8:56,440,957...56,446,641
Ensembl chr 8:56,436,674...56,446,671
JBrowse link
G PPP1R1B protein phosphatase 1 regulatory inhibitor subunit 1B treatment ISO associated with Parkinsonian Disorders RGD PMID:27771532 RGD:13514053 NCBI chr17:39,626,707...39,636,624
Ensembl chr17:39,626,740...39,636,626
JBrowse link
G RASGRF1 Ras protein specific guanine nucleotide releasing factor 1 EXP CTD Direct Evidence: therapeutic CTD PMID:21115823 NCBI chr15:78,959,906...79,090,780
Ensembl chr15:78,959,906...79,090,780
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:nucleus, brain RGD PMID:18590723 RGD:2298778 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G RGS4 regulator of G protein signaling 4 treatment ISO associated with Parkinsonian Disorders RGD PMID:24969021 RGD:13524515 NCBI chr 1:163,068,871...163,076,802
Ensembl chr 1:163,068,775...163,076,802
JBrowse link
G RGS9 regulator of G protein signaling 9 EXP CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:18160641 PMID:24663062 NCBI chr17:65,137,370...65,227,703
Ensembl chr17:65,100,812...65,227,703
JBrowse link
G TH tyrosine hydroxylase EXP CTD Direct Evidence: therapeutic CTD PMID:15659429 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815
JBrowse link
Tardive Dyskinesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 treatment IAGP associated with schizophrenia RGD PMID:10889552 RGD:1358545 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G DRD3 dopamine receptor D3 IAGP associated with schizophrenia RGD PMID:12960753 RGD:1581250 NCBI chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407
JBrowse link
G SOD2 superoxide dismutase 2 IAGP associated with schizophrenia RGD PMID:12960753 RGD:1581250 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 121159
    syndrome 38910
      toxic encephalopathy 231
        Drug-Induced Dyskinesia 53
          Tardive Dyskinesia 3
Path 2
Term Annotations click to browse term
  disease 121159
    disease of anatomical entity 111930
      nervous system disease 58665
        central nervous system disease 40433
          brain disease 37911
            movement disease 4123
              Dyskinesias 2882
                Drug-Induced Dyskinesia 53
                  Tardive Dyskinesia 3
paths to the root