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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Drug-Induced Dyskinesia
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Accession:DOID:9008394 term browser browse the term
Definition:Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)
Synonyms:exact_synonym: Drug-Induced Dyskinesias;   Medication Induced Dyskinesia;   Medication-Induced Dyskinesias
 primary_id: MESH:D004409
 xref: EFO:1000904


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Drug-Induced Dyskinesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABAT 4-aminobutyrate aminotransferase ISO RGD PMID:6445277 PMID:7740056 RGD:10047091 RGD:1598524 NCBI chr 5:8,274,310...8,380,973
Ensembl chr 5:8,315,952...8,379,549
JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:18947822 RGD:6906919 NCBI chr22:14,868,459...15,195,002
Ensembl chr22:15,027,565...15,197,101
JBrowse link
G CAT catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19109989 NCBI chr 1:30,792,533...30,828,920
Ensembl chr 1:30,792,399...30,829,592
JBrowse link
G CCK cholecystokinin ISO CTD Direct Evidence: therapeutic CTD PMID:2320253 NCBI chr22:3,698,192...3,705,443
Ensembl chr22:3,698,173...3,704,956
JBrowse link
G COMT catechol-O-methyltransferase ISO RGD PMID:16437585 RGD:2289781 NCBI chr19:5,775,829...5,803,260
Ensembl chr19:5,773,225...5,785,422
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 ISO RGD PMID:12629505 RGD:1358549 NCBI chr19:24,667,207...24,672,580
Ensembl chr19:24,667,282...24,671,513
JBrowse link
G DBN1 drebrin 1 ISO levodopainduced; protein:increased expression:striatum: RGD PMID:23241013 RGD:10398811 NCBI chr23:79,468,010...79,484,603
Ensembl chr23:79,467,647...79,484,592
JBrowse link
G DDC dopa decarboxylase ISO associated with Parkinson Disease; protein:decreased expression:striatum (rat) RGD PMID:20232137 RGD:5128860 NCBI chr21:8,235,396...8,343,086
Ensembl chr21:8,235,343...8,343,361
JBrowse link
G DRD1 dopamine receptor D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7845605 PMID:10858612 PMID:16982285 PMID:19520364 NCBI chr23:77,587,340...77,591,434 JBrowse link
G DRD2 dopamine receptor D2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:7845605 PMID:10534246 PMID:14629710 PMID:18707801 RGD:2311579 NCBI chr 1:104,774,632...104,843,417
Ensembl chr 1:104,774,180...104,842,736
JBrowse link
G DRD3 dopamine receptor D3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20945430 NCBI chr22:66,683,987...66,737,645
Ensembl chr22:66,691,177...66,736,690
JBrowse link
G EGR1 early growth response 1 ISO RGD PMID:22153973 RGD:10395307 NCBI chr23:41,139,636...41,143,598
Ensembl chr23:41,140,065...41,142,374
JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:17219962 NCBI chr 6:38,916,039...38,924,129 JBrowse link
G GAD1 glutamate decarboxylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9767399 NCBI chr10:56,351,495...56,396,476
Ensembl chr10:56,353,253...56,396,524
JBrowse link
G GCH1 GTP cyclohydrolase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:15659429 NCBI chr24:32,029,997...32,079,656
Ensembl chr24:32,027,648...32,079,490
JBrowse link
G GDNF glial cell derived neurotrophic factor ISO CTD Direct Evidence: therapeutic CTD PMID:11168568 NCBI chr 4:36,662,033...36,691,761
Ensembl chr 4:36,665,009...36,684,257
JBrowse link
G GLUL glutamate-ammonia ligase ISO RGD PMID:6445277 RGD:10047091 NCBI chr25:46,988,853...46,998,112
Ensembl chr25:46,989,205...47,000,555
JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO associated with Parkinson Disease RGD PMID:20410529 RGD:5684919 NCBI chr23:79,437,056...79,454,213
Ensembl chr23:79,437,078...79,453,113
JBrowse link
G GSK3B glycogen synthase kinase 3 beta treatment ISO associated with Parkinsonian Disorders RGD PMID:26997328 RGD:13792768 NCBI chr22:60,732,449...61,002,735
Ensembl chr22:60,733,465...60,997,239
JBrowse link
G HOMER1 homer scaffold protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24126708 NCBI chr 4:73,591,105...73,729,680
Ensembl chr 4:73,589,495...73,728,353
JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A ISO RGD PMID:21352823 RGD:5683628 NCBI chr 4:60,159,542...60,162,947
Ensembl chr 4:60,159,944...60,161,212
JBrowse link
G MAPT microtubule associated protein tau treatment ISO associated with Parkinsonian Disorders RGD PMID:25511986 RGD:13800920 NCBI chr16:59,894,400...60,020,723
Ensembl chr16:59,890,221...59,955,612
JBrowse link
G MTOR mechanistic target of rapamycin kinase treatment ISO associated with Parkinsonian Disorders RGD PMID:23938307 RGD:10040953 NCBI chr20:120,522,667...120,678,988
Ensembl chr20:120,525,737...120,679,020
JBrowse link
G PDYN prodynorphin treatment
severity
ISO CTD Direct Evidence: marker/mechanism
associated with Parkinsonism
associated with Parkinsonism;protein:increased expression:striatum
CTD
RGD
PMID:9767399 PMID:10869049 PMID:17884291 PMID:21737418 RGD:401850563 RGD:401851046 RGD:401900134 NCBI chr 2:54,535,516...54,551,085
Ensembl chr 2:54,535,240...54,551,104
JBrowse link
G PENK proenkephalin treatment
disease_progression
ISO mRNA:increased expression:brain:striatum:
associated with Parkinsonism
associated with Parkinsonism;mRNA:increased expression:striatum
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:9767399 PMID:10869049 PMID:20456008 PMID:26113400 RGD:10003039 RGD:401851054 RGD:401900134 NCBI chr 8:52,458,113...52,463,933
Ensembl chr 8:52,457,904...52,463,859
JBrowse link
G PPP1R1B protein phosphatase 1 regulatory inhibitor subunit 1B treatment ISO associated with Parkinsonian Disorders RGD PMID:27771532 RGD:13514053 NCBI chr16:66,530,640...66,541,025
Ensembl chr16:66,530,488...66,541,242
JBrowse link
G RASGRF1 Ras protein specific guanine nucleotide releasing factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:21115823 NCBI chr26:4,298,091...4,431,606
Ensembl chr26:4,299,116...4,432,420
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:nucleus, brain RGD PMID:18590723 RGD:2298778 NCBI chr 1:8,576,059...8,585,561
Ensembl chr 1:8,576,542...8,586,516
JBrowse link
G RGS4 regulator of G protein signaling 4 treatment ISO associated with Parkinsonian Disorders RGD PMID:24969021 RGD:13524515 NCBI chr25:65,729,344...65,735,278
Ensembl chr25:65,726,394...65,735,381
JBrowse link
G RGS9 regulator of G protein signaling 9 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:18160641 PMID:24663062 NCBI chr16:56,199,051...56,291,002
Ensembl chr16:56,199,343...56,288,290
JBrowse link
G TH tyrosine hydroxylase ISO CTD Direct Evidence: therapeutic CTD PMID:15659429 NCBI chr 1:1,969,194...1,977,263
Ensembl chr 1:1,966,460...1,977,218
JBrowse link
Tardive Dyskinesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 treatment ISO associated with schizophrenia RGD PMID:10889552 RGD:1358545 NCBI chr26:8,727,996...8,733,254 JBrowse link
G DRD3 dopamine receptor D3 ISO associated with schizophrenia RGD PMID:12960753 RGD:1581250 NCBI chr22:66,683,987...66,737,645
Ensembl chr22:66,691,177...66,736,690
JBrowse link
G SOD2 superoxide dismutase 2 ISO associated with schizophrenia RGD PMID:12960753 RGD:1581250 NCBI chr13:87,284,537...87,297,998
Ensembl chr13:87,280,686...87,297,974
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15417
    syndrome 10457
      toxic encephalopathy 201
        Drug-Induced Dyskinesia 33
          Tardive Dyskinesia 3
Path 2
Term Annotations click to browse term
  disease 15417
    disease of anatomical entity 15080
      nervous system disease 13230
        central nervous system disease 11819
          brain disease 11089
            movement disease 2514
              Dyskinesias 2140
                Drug-Induced Dyskinesia 33
                  Tardive Dyskinesia 3
paths to the root