RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Eye Infections
Accession: DOID:9008201
browse the term
Definition: Infection, moderate to severe, caused by bacteria, fungi, or viruses, which occurs either on the external surface of the eye or intraocularly with probable inflammation, visual impairment, or blindness.
Synonyms: exact_synonym: Eye Infection; Ocular Infection; Ocular Infections
xref: EFO:1001888 ; MESH:D015817 ; MONDO:0043885
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Tlr4
toll-like receptor 4
IEP
mRNA,protein:increased expression:cornea
RGD
PMID:21155840
RGD:7777095
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Il1rl1
interleukin 1 receptor-like 1
treatment
ISO
mRNA:increased expression:brain:
RGD
PMID:24657070 PMID:23148283
RGD:11561855 , RGD:40400713
NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
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Il33
interleukin 33
ISO
protein:increased expression:brain:
RGD
PMID:23148283 PMID:24076431
RGD:40400713 , RGD:40400715
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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Il5
interleukin 5
ISO
RGD
PMID:8361777
RGD:11354948
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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Mag
myelin-associated glycoprotein
disease_progression
ISO
RGD
PMID:20399564
RGD:27226693
NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656
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Mbp
myelin basic protein
disease_progression
ISO
RGD
PMID:20399564
RGD:27226693
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
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Mobp
myelin-associated oligodendrocyte basic protein
disease_progression
ISO
RGD
PMID:20399564
RGD:27226693
NCBI chr 8:119,869,504...119,899,605
Ensembl chr 8:119,869,626...119,899,563
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Muc1
mucin 1, cell surface associated
ISO
RGD
PMID:10359313
RGD:7349379
NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
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Tlr2
toll-like receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23661603
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Il1r1
interleukin 1 receptor type 1
ISO
associated with Serratia Infections;
RGD
PMID:23033384
RGD:8662876
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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Ly96
lymphocyte antigen 96
ISO
associated with Serratia Infections;
RGD
PMID:23033384
RGD:8662876
NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386
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Myd88
MYD88, innate immune signal transduction adaptor
ISO
associated with Staphylococcal Infections; associated with Serratia Infections;
RGD
PMID:16926427 PMID:23033384
RGD:8552819 , RGD:8662876
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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Tlr2
toll-like receptor 2
ISO
associated with Staphylococcal Infections; associated with Pneumococcal Infections;
RGD
PMID:16926427 PMID:23841825
RGD:8552819 , RGD:8552886
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4
toll-like receptor 4
ISO
associated with Pneumococcal Infections; associated with Serratia Infections;
RGD
PMID:23841825 PMID:23033384
RGD:8552886 , RGD:8662876
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tlr5
toll-like receptor 5
ISO
associated with Serratia Infections;
RGD
PMID:23033384
RGD:8662876
NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738
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Il6
interleukin 6
ISO
associated with Arthritis,Rheumatoid;mRNA:increased expression:keratocyte:
RGD
PMID:12714388
RGD:7829721
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
ISO
associated with Hypersensitivity;mRNA:decreased expression:eye
RGD
PMID:16251127
RGD:7364739
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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Ngf
nerve growth factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24244623
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Serpinf1
serpin family F member 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:19553628
NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
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Tnf
tumor necrosis factor
ISO
associated with Arthritis,Rheumatoid;mRNA:increased expression:keratocyte:
RGD
PMID:12714388
RGD:7829721
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Il10
interleukin 10
ISO
associated with Murine Acquired Immunodeficiency Syndrome
RGD
PMID:23415673
RGD:7364815
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Ripk3
receptor-interacting serine-threonine kinase 3
ISO
protein:increased expression:optic cup, retina (mouse)
RGD
PMID:29853772
RGD:127229940
NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
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RT1-CE13
RT1 class I, locus CE13
ISO
associated with HIV Infections; DNA:polymorphisms, haplotype:cds:HLA-B44 (human)
RGD
PMID:11564593
RGD:7365106
NCBI chr20:3,314,830...3,318,106
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Tnf
tumor necrosis factor
ISO
mRNA,protein:increased expression:eye:
RGD
PMID:22072377 PMID:17389501
RGD:7394768 , RGD:7394808
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf1a
TNF receptor superfamily member 1A
ISO
RGD
PMID:17389501
RGD:7394808
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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Fas
Fas cell surface death receptor
IEP
protein:increased expression:retinal ganglion cell, bipolar cell of retina, photoreceptor (rat)
RGD
PMID:19039600
RGD:8662445
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Ifng
interferon gamma
IEP
protein:increased expression:vitreous:
RGD
PMID:16544114
RGD:7829753
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il1b
interleukin 1 beta
IEP
protein:increased expression:vitreous:
RGD
PMID:16544114
RGD:7829753
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Slpi
secretory leukocyte peptidase inhibitor
IEP
associated with Staphylococcal Infections;protein:increased expression:cornea, retina, vitreous humor
RGD
PMID:18274645
RGD:9999421
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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Tlr2
toll-like receptor 2
ISO
RGD
PMID:19995266 PMID:22163046
RGD:8552880 , RGD:8553060
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tnf
tumor necrosis factor
IEP
protein:increased expression:vitreous:
RGD
PMID:16544114
RGD:7829753
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tlr2
toll-like receptor 2
IEP
mRNA:increased expression:cornea
RGD
PMID:19474209
RGD:2312502
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4
toll-like receptor 4
IEP
mRNA:increased expression:cornea
RGD
PMID:19474209
RGD:2312502
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Clec7a
C-type lectin domain containing 7A
treatment
ISO
mRNA:increased expression:cornea
RGD
PMID:26963514 PMID:26963514
RGD:11526921 , RGD:11526921
NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897
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Tlr4
toll-like receptor 4
ISO
RGD
PMID:20617171
RGD:7794847
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Trem1
triggering receptor expressed on myeloid cells 1
treatment
ISO
mRNA:increased expression:cornea
RGD
PMID:26963514 PMID:26963514 PMID:26963514
RGD:11526921 , RGD:11526921 , RGD:11526921
NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
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Tslp
thymic stromal lymphopoietin
disease_progression
ISO
RGD
PMID:29550278 PMID:30853520
RGD:38549371 , RGD:38549574
NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
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Apoe
apolipoprotein E
treatment
ISO
RGD
PMID:18515564
RGD:7771550
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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Atm
ATM serine/threonine kinase
ameliorates
ISO
RGD
PMID:24370835
RGD:126781690
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Ccl2
C-C motif chemokine ligand 2
severity
ISO
associated with Herpes Simplex, Type 1
RGD
PMID:16997857
RGD:8548890
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl20
C-C motif chemokine ligand 20
ISO
RGD
PMID:15287366
RGD:7483593
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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Ccr5
C-C motif chemokine receptor 5
ISO
RGD
PMID:18798077 PMID:16476970
RGD:8551819 , RGD:8551837
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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Ccr6
C-C motif chemokine receptor 6
ISO
RGD
PMID:15287366
RGD:7483593
NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603
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Cd274
CD274 molecule
ISO
RGD
PMID:16253242
RGD:41410794
NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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Cxcr3
C-X-C motif chemokine receptor 3
ISO
RGD
PMID:18798077
RGD:8551819
NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969
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Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
treatment
ISO
RGD
PMID:15670795
RGD:40902819
NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
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Ifnb1
interferon beta 1
treatment
ISO
RGD
PMID:15670795
RGD:40902819
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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Ifng
interferon gamma
ISO
RGD
PMID:12162877
RGD:8157603
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il10
interleukin 10
treatment
ISO
RGD
PMID:22467659
RGD:7364834
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1b
interleukin 1 beta
ISO
mRNA:increased expression:cornea
RGD
PMID:10624423
RGD:7401196
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il1rn
interleukin 1 receptor antagonist
treatment
ISO
human protein in a mouse model
RGD
PMID:15258192
RGD:8549793
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Il21
interleukin 21
treatment
ISO
RGD
PMID:29370719 PMID:21204603
RGD:127285376 , RGD:127285545
NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996
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Il23a
interleukin 23 subunit alpha
ISO
mRNA;increased expression:trigeminal ganglion (mouse)
RGD
PMID:12162874
RGD:39457946
NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
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Kdr
kinase insert domain receptor
treatment
ISO
protein:increased expression:cornea:
RGD
PMID:16951377 PMID:16951377
RGD:8549742 , RGD:8549742
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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Rnasel
ribonuclease L
treatment
ISO
RGD
PMID:15670795
RGD:40902819
NCBI chr13:65,894,990...65,910,354
Ensembl chr13:65,901,459...65,908,704
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Stat4
signal transducer and activator of transcription 4
susceptibility
ISO
RGD
PMID:17266445
RGD:8661706
NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540
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Tlr2
toll-like receptor 2
ISO
RGD
PMID:17686871
RGD:7794851
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4
toll-like receptor 4
ISO
mRNA:increased expression:cornea:
RGD
PMID:17686871 PMID:17667620
RGD:7794851 , RGD:8552970
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tlr9
toll-like receptor 9
ISO
RGD
PMID:17686871
RGD:7794851
NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
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Tnf
tumor necrosis factor
ISO
mRNA:increased expression:cornea
RGD
PMID:10624423 PMID:12162877
RGD:7401196 , RGD:8157603
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Il1r1
interleukin 1 receptor type 1
ISO
RGD
PMID:19168746
RGD:8662882
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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Tlr4
toll-like receptor 4
ISO
RGD
PMID:11884755
RGD:7794682
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Anxa1
annexin A1
ISO
RGD
PMID:22740770
RGD:7421536
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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Il10
interleukin 10
ISO
RGD
PMID:19026704
RGD:7365028
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il17a
interleukin 17A
treatment
ISO
protein:increased expression:aqueous humor (human)
RGD
PMID:22927448 PMID:22927448
RGD:8698652 , RGD:8698652
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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Il27
interleukin 27
disease_progression
ISO
mRNA:increased expression:eye, cervical lymph node (mouse)
RGD
PMID:29779048
RGD:126790500
NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
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Nod2
nucleotide-binding oligomerization domain containing 2
susceptibility
ISO
DNA:snp:3' utr:g.*397A>C (rs3135499)(human)
RGD
PMID:23100559
RGD:8547527
NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
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Il10
interleukin 10
ISO
protein:increased expression:aqueous humor
RGD
PMID:22583692
RGD:7364832
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Cebpb
CCAAT/enhancer binding protein beta
treatment
ISO
mRNA, protein:increased expression:cornea (mouse)
RGD
PMID:23626014
RGD:40903020
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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Icam1
intercellular adhesion molecule 1
ISO
RGD
PMID:9916118
RGD:8547701
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Il10
interleukin 10
treatment
ISO
RGD
PMID:23878501
RGD:7364804
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il18
interleukin 18
ISO
RGD
PMID:12023376
RGD:8655931
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1b
interleukin 1 beta
ISO
RGD
PMID:11895986
RGD:7401195
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il1rn
interleukin 1 receptor antagonist
treatment
ISO
mRNA:increased expression:cornea (mouse)
RGD
PMID:11895986 PMID:9423885
RGD:7401195 , RGD:8549805
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Il6
interleukin 6
ISO
RGD
PMID:11349084
RGD:7829813
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mmp9
matrix metallopeptidase 9
treatment
ISO
RGD
PMID:16384971
RGD:8547891
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Tlr2
toll-like receptor 2
ISO
mRNA,protein:increased expression:cornea:
RGD
PMID:20012880
RGD:8552969
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4
toll-like receptor 4
ISO
mRNA,protein:increased expression:cornea:
RGD
PMID:17065506 PMID:20012880
RGD:7794775 , RGD:8552969
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tslp
thymic stromal lymphopoietin
severity
ISO
RGD
PMID:30128494
RGD:38596331
NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
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Il10
interleukin 10
no_association severity
ISO
protein:increased expression:tear DNA:SNP:promoter:−1082G>A (human) DNA:SNP:promoter:−819T>C, −592A>C (human) DNA:SNP, haplotype:promoter:−1082G>A (human) DNA:haplotype: :
RGD
PMID:18628987 PMID:11023480 PMID:11023480 PMID:15789056 PMID:17947295
RGD:7365037 , RGD:7365085 , RGD:7365085 , RGD:7365072 , RGD:7365053
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il17a
interleukin 17A
ISO
mRNA:increased expression:conjunctiva (human)
RGD
PMID:21911461
RGD:9068420
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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RT1-CE13
RT1 class I, locus CE13
ISO
DNA:polymorphisms:cds:HLA-B*14 (human, Tanzanian)
RGD
PMID:18824733
RGD:7364877
NCBI chr20:3,314,830...3,318,106
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Tnf
tumor necrosis factor
ISO
DNA:SNP, haplotypes:promoter:−308G>A (human)
RGD
PMID:17330135
RGD:8548830
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Col1a1
collagen type I alpha 1 chain
ISO
mRNA:decreased expression:tarsal conjunctiva (human)
RGD
PMID:20375326
RGD:8552676
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Cd1d1
CD1d1 molecule
exacerbates
ISO
associated with Herpesviridae Infections
RGD
PMID:30185591
RGD:127345098
NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089
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