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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Sleep Deprivation
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Accession:DOID:9007980 term browser browse the term
Definition:The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.
Synonyms:exact_synonym: Insufficient Sleep Syndrome;   Insufficient Sleep Syndromes;   REM Sleep Deprivation;   REM Sleep Deprivations;   Sleep Deprivations;   Sleep Fragmentation;   Sleep Fragmentations
 primary_id: MESH:D012892


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Sleep Deprivation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bace1 beta-secretase 1 IEP protein:increased expression:brain: RGD PMID:28455102 RGD:13782059 NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918 		JBrowse link
G Bdnf brain-derived neurotrophic factor treatment IEP RGD PMID:25450575 RGD:10059355 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Crh corticotropin releasing hormone IEP mRNA, protein:increased expression:paraventricular nucleus of thalamus RGD PMID:16210372 RGD:407580523 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386 		JBrowse link
G Cst3 cystatin C IEP RGD PMID:17027151 RGD:2306498 NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937 		JBrowse link
G Ctsh cathepsin H IEP RGD PMID:17027151 RGD:2306498 NCBI chr 8:99,488,756...99,507,639
Ensembl chr 8:99,488,874...99,509,181 		JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase IEP mRNA:decreased expression:cerebral cortex RGD PMID:16923172 RGD:2313667 NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:59,868,214...59,900,818
Ensembl chr 1:59,868,214...59,900,818 		JBrowse link
G Drd1 dopamine receptor D1 IEP protein:increased expression:hypothalamus RGD PMID:25433096 RGD:13506946 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 IEP protein:hyperphosphorylation:prefrontal cortex, dentate gyrus; RGD PMID:22917528 RGD:10401259 NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:9,183,961...9,189,544 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B IEP protein:decreased expression:hippocampus (rat) RGD PMID:20237303 RGD:4107020 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570 		JBrowse link
G Gsr glutathione-disulfide reductase IEP protein:increased expression:hippocampus, cortex, amygdala: RGD PMID:21621560 RGD:11059509 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Jph3 junctophilin 3 ISO mRNA:increased expression:brain RGD PMID:18077435 RGD:6480426 NCBI chr19:66,702,497...66,763,948
Ensembl chr19:66,702,680...66,763,937 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IEP mRNA, protein:decreased expression:mandible condylar process RGD PMID:23859770 RGD:7495827 NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185 		JBrowse link
G Mir223 microRNA 223 IEP RGD PMID:30225174 RGD:25824951 NCBI chr  X:65,151,383...65,151,492
Ensembl chr  X:65,151,383...65,151,492 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase IEP RNA:increased expression:liver: RGD PMID:28860003 RGD:13781877 NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:55,151,926...55,189,544 		JBrowse link
G Ngb neuroglobin IEP protein:decreased expression:brain RGD PMID:23262504 RGD:9743966 NCBI chr 6:112,475,332...112,480,786
Ensembl chr 6:112,475,332...112,480,786 		JBrowse link
G Npy neuropeptide Y IEP mRNA:increased expression:paraventricular nucleus of thalamus RGD PMID:16210372 RGD:407580523 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310 		JBrowse link
G Nrgn neurogranin IEP RGD PMID:7583240 RGD:9835425 NCBI chr 8:45,444,223...45,452,417
Ensembl chr 8:45,444,223...45,452,417 		JBrowse link
G Pomc proopiomelanocortin IEP mRNA:decreased expression:paraventricular nucleus of thalamus RGD PMID:16210372 RGD:407580523 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16343605 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO mRNA:increased expression:brain RGD PMID:18077435 RGD:6480426 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      nervous system disease 14369
        Neurologic Manifestations 10446
          sleep disorder 154
            Dyssomnias 131
              Sleep Deprivation 20
Path 2
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      nervous system disease 14369
        central nervous system disease 12646
          brain disease 11866
            disease of mental health 8496
              sleep disorder 154
                Dyssomnias 131
                  Sleep Deprivation 20
paths to the root