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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Arsenic Poisoning
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Accession:DOID:9007964 term browser browse the term
Definition:Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)
Synonyms:exact_synonym: Arsenic Encephalopathies;   Arsenic Encephalopathy;   Arsenic Induced Polyneuropathy;   Arsenic Poisoning, Nervous System;   Arsenic Poisonings;   Arsenic-Induced Polyneuropathies;   Arsenical Neurotoxicity Syndrome;   Arsenical Neurotoxicity Syndromes;   Inorganic Arsenic Poisoning;   Inorganic Arsenic Poisonings;   Nervous System, Organic Arsenic Poisoning;   Organic Arsenic Poisoning;   Organic Arsenic Poisonings
 primary_id: MESH:D020261;   RDO:0007378


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Arsenic Poisoning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap9 A-kinase anchoring protein 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 4:31,011,475...31,147,338
Ensembl chr 4:30,056,738...30,192,606 		JBrowse link
G Alad aminolevulinate dehydratase IEP protein:decreased activity:blood (rat) RGD PMID:19022878 RGD:4144202 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Aqp9 aquaporin 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19805235 NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G As3mt arsenite methyltransferase ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:21447609 PMID:26366667 PMID:35226250 NCBI chr 1:255,536,879...255,569,245
Ensembl chr 1:245,596,108...245,627,872 		JBrowse link
G Atxn7 ataxin 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr15:13,547,859...13,693,311
Ensembl chr15:11,118,886...11,263,106 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccrl2 C-C motif chemokine receptor like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 8:119,912,671...119,915,313
Ensembl chr 8:111,034,279...111,036,664 		JBrowse link
G Cd44 CD44 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd83 CD83 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr17:21,093,281...21,113,223
Ensembl chr17:20,887,309...20,907,083 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO protein:increased expression:skin: RGD PMID:11860939 RGD:8662429 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Crp C-reactive protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:22521605 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12569548 NCBI chr 1:88,099,308...88,135,966
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12569548 NCBI chr18:24,157,831...24,188,543
Ensembl chr18:23,883,580...23,914,329 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12569548 NCBI chr10:2,926,085...2,958,176
Ensembl chr10:2,419,038...2,448,369
Ensembl chr10:2,419,038...2,448,369 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:8,778,007...8,780,046 		JBrowse link
G Golga4 golgin A4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 8:127,085,830...127,163,227 JBrowse link
G Gsr glutathione-disulfide reductase IEP RGD PMID:25209654 RGD:10401880 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Id2 inhibitor of DNA binding 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Ier3 immediate early response 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Igf2bp2 insulin-like growth factor 2 mRNA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chr11:92,378,908...92,478,893
Ensembl chr11:78,874,414...78,974,377 		JBrowse link
G Il1a interleukin 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Inpp5a inositol polyphosphate-5-phosphatase A ISO CTD Direct Evidence: marker/mechanism CTD PMID:25759212 NCBI chr 1:203,619,676...203,810,035
Ensembl chr 1:194,190,393...194,380,428 		JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr10:96,560,225...96,570,788
Ensembl chr10:96,060,821...96,071,445 		JBrowse link
G Krt10 keratin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19953893 NCBI chr10:84,834,865...84,839,160
Ensembl chr10:84,338,706...84,343,701 		JBrowse link
G Mettl14 methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chr 2:214,215,165...214,231,412
Ensembl chr 2:211,530,602...211,546,821 		JBrowse link
G Minpp1 multiple inositol-polyphosphate phosphatase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 1:230,354,483...230,379,730
Ensembl chr 1:230,354,438...230,379,730 		JBrowse link
G Mir145 microRNA 145 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29705342 NCBI chr18:57,369,983...57,370,070
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Mir155 microRNA 155 ISO miRNA:increased expression:serum RGD PMID:27913196 RGD:25314296 NCBI chr11:37,261,114...37,261,178
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mt1 metallothionein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19953893 NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24384392 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G N4bp2l2 NEDD4 binding protein 2-like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr12:137,342...200,292
Ensembl chr12:103,590...197,784 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:243,408,619...243,413,817 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Pde4b phosphodiesterase 4B ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr14:99,455,970...99,510,474
Ensembl chr14:95,254,589...95,308,285
Ensembl chr 1:95,254,589...95,308,285 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr17:71,893,320...71,974,526
Ensembl chr17:66,983,686...67,063,125 		JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 8:72,233,566...72,347,085
Ensembl chr 8:63,338,150...63,438,905 		JBrowse link
G Pnp purine nucleoside phosphorylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18414634 NCBI chr15:26,644,147...26,651,808
Ensembl chr15:24,170,602...24,203,986 		JBrowse link
G Ptx3 pentraxin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:150,487,513...150,493,323 		JBrowse link
G Rfx3 regulatory factor X3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 1:234,863,462...235,122,989
Ensembl chr 1:225,456,187...225,709,402 		JBrowse link
G Rgs1 regulator of G-protein signaling 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr13:58,568,844...58,573,187
Ensembl chr13:56,018,554...56,022,984 		JBrowse link
G Rnf20 ring finger protein 20 ISO protein:increased expression:urine (human) RGD PMID:21136906 RGD:9831407 NCBI chr 5:68,771,507...68,797,240
Ensembl chr 5:63,976,045...64,001,754 		JBrowse link
G Rufy3 RUN and FYVE domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr14:19,715,593...19,790,530
Ensembl chr14:19,432,524...19,507,004 		JBrowse link
G Sfpq splicing factor proline and glutamine rich ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 5:144,621,678...144,637,930
Ensembl chr 5:139,338,075...139,353,472 		JBrowse link
G Skil SKI-like proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 2:114,175,534...114,203,663
Ensembl chr 2:112,247,051...112,275,080 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sox18 SRY-box transcription factor 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:189,163,000...189,164,802
Ensembl chr 3:168,785,490...168,787,290 		JBrowse link
G Srp68 signal recognition particle 68 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr10:101,980,089...102,006,913
Ensembl chr10:101,481,212...101,508,035 		JBrowse link
G Ssbp1 single stranded DNA binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 4:70,232,740...70,242,824
Ensembl chr 4:69,266,102...69,276,135 		JBrowse link
G Taf1d TATA-box binding protein associated factor, RNA polymerase I subunit D ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 8:20,427,894...20,438,046
Ensembl chr 8:12,146,605...12,156,618 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Tnik TRAF2 and NCK interacting kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 2:113,112,937...113,511,341
Ensembl chr 2:111,184,387...111,580,750 		JBrowse link
G Tp53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18621066 PMID:19203779 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tra2a transformer 2 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 4:79,551,699...79,570,621
Ensembl chr 4:78,220,883...78,239,712 		JBrowse link
G Trappc10 trafficking protein particle complex subunit 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr20:10,438,404...10,498,740
Ensembl chr20:10,438,737...10,499,074 		JBrowse link
G Ube2e1 ubiquitin-conjugating enzyme E2E 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr15:9,870,528...9,924,194
Ensembl chr15:7,439,759...7,493,400 		JBrowse link
G Uso1 USO1 vesicle transport factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr14:16,150,921...16,216,389
Ensembl chr14:15,866,638...15,932,171 		JBrowse link
G Usp13 ubiquitin specific peptidase 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 2:117,502,811...117,617,049
Ensembl chr 2:115,577,091...115,686,222 		JBrowse link
G Zfand6 zinc finger AN1-type containing 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 1:147,990,099...148,061,221
Ensembl chr 1:138,581,002...138,651,939 		JBrowse link
G Zfp267 zinc finger protein 267 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 2:120,945,434...120,964,039
Ensembl chr 2:119,017,285...119,031,900 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19139
    Chemically-Induced Disorders 1462
      Poisoning 790
        Arsenic Poisoning 67
Path 2
Term Annotations click to browse term
  disease 19139
    disease of anatomical entity 18451
      nervous system disease 14361
        toxic encephalopathy 248
          Heavy Metal Poisoning, Nervous System 86
            Arsenic Poisoning 67
paths to the root