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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Sepsis-Associated Encephalopathy
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Accession:DOID:9007842 term browser browse the term
Definition:Acute neurological dysfunction during severe SEPSIS in the absence of direct brain infection characterized by systemic inflammation and BLOOD BRAIN BARRIER perturbation.
Synonyms:exact_synonym: Sepsis Associated Delirium;   Sepsis Associated Deliriums;   Sepsis Associated Encephalopathies
 primary_id: MESH:D065166


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Sepsis-Associated Encephalopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 IEP protein:decreased expression:corpus callosum RGD PMID:31622656 RGD:598092488 NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339 		JBrowse link
G Aqp4 aquaporin 4 IEP protein:decreased expression:cerebral cortex RGD PMID:31622656 RGD:598092488 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098 		JBrowse link
G Gfap glial fibrillary acidic protein IEP protein:decreased expression:corpus callosum RGD PMID:31622656 RGD:598092488 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685 		JBrowse link
G Jak2 Janus kinase 2 treatment IDA RGD PMID:23236988 RGD:10403076 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Nefh neurofilament heavy chain severity ISO RGD PMID:30677080 RGD:27226881 NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417 		JBrowse link
G Nefl neurofilament light chain disease_progression ISO RGD PMID:30677080 RGD:27226881 NCBI chr15:46,477,330...46,481,203
Ensembl chr15:46,458,204...46,482,515 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IEP protein:decreased expression:cerebral cortex RGD PMID:31622656 RGD:598092488 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 treatment IDA RGD PMID:23236988 RGD:10403076 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14566
    disease of anatomical entity 13676
      nervous system disease 8528
        central nervous system disease 6393
          brain disease 5852
            Sepsis-Associated Encephalopathy 8
paths to the root