RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Myocardial Reperfusion Injury
Accession: DOID:9007838
browse the term
Definition: Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
Synonyms: exact_synonym: Myocardial Ischemic Reperfusion Injury; Myocardial Reperfusion Injuries
primary_id: MESH:D015428
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Abcc8
ATP binding cassette subfamily C member 8
ISO
RGD
PMID:18316485
RGD:2301903
NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
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Acvr2b
activin A receptor type 2B
treatment
ISO
human construct in mouse model mRNA, protein:decreased expression:heart (mouse)
RGD
PMID:30765322 PMID:30765322
RGD:329849112 , RGD:329849112
NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458
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Ada
adenosine deaminase
IDA
protein:increased expression
RGD
PMID:16641873
RGD:1624305
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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Adipoq
adiponectin, C1Q and collagen domain containing
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16155579
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Adrb1
adrenoceptor beta 1
IMP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:10900253 PMID:17201736
RGD:5129149
NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259
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Adrb2
adrenoceptor beta 2
IDA
RGD
PMID:16269402
RGD:1598746
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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Ager
advanced glycosylation end product-specific receptor
IEP
protein:increased expression:heart (rat)
RGD
PMID:16505177
RGD:1625342
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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Agl
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
IMP
RGD
PMID:9281456
RGD:1598779
NCBI chr 2:204,705,053...204,760,966
Ensembl chr 2:204,705,053...204,760,828
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Agt
angiotensinogen
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:2535056 PMID:19166939
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Agtr1a
angiotensin II receptor, type 1a
IEP
protein:increased expression:myocardium
RGD
PMID:21078800
RGD:5129194
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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Ahr
aryl hydrocarbon receptor
treatment
IMP
RGD
PMID:35788946
RGD:401793705
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Aifm1
apoptosis inducing factor, mitochondria associated 1
IEP ISO
protein:decreased expression:mitochondrion:
RGD
PMID:23685150 PMID:23685150
RGD:10053560 , RGD:10053560
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Akt1
AKT serine/threonine kinase 1
IDA
protein:increased phosphorylation:heart left ventricle
RGD
PMID:20217242
RGD:5509104
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Akt2
AKT serine/threonine kinase 2
IDA
RGD
PMID:16418318
RGD:2313347
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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Alb
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9572063
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Aldh2
aldehyde dehydrogenase 2 family member
IDA
RGD
PMID:23468836
RGD:7241598
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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Alox5
arachidonate 5-lipoxygenase
IMP
RGD
PMID:20011686
RGD:2317527
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Angpt2
angiopoietin 2
IEP
mRNA, protein:increased expression:myocardium (rat)
RGD
PMID:12737621
RGD:1601505
NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
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Ank1
ankyrin 1
IDA
RGD
PMID:9378703
RGD:1599110
NCBI chr16:68,876,294...69,054,963
Ensembl chr16:68,877,504...69,054,759
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Ank2
ankyrin 2
IDA
RGD
PMID:9378703
RGD:1599110
NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923
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Ankrd1
ankyrin repeat domain 1
IEP
protein:decreased expression:myocardium
RGD
PMID:19299913
RGD:5133278
NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
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Anxa1
annexin A1
treatment
IEP ISO
protein:increased expression:heart, leukocyte
RGD
PMID:11641252 PMID:22924634 PMID:22924634
RGD:2306910 , RGD:7421655 , RGD:7421655
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
IEP
protein:altered localization:cytoplasm
RGD
PMID:17602955
RGD:2315672
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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Arrb2
arrestin, beta 2
IEP
RGD
PMID:29016703
RGD:13506827
NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
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Atf3
activating transcription factor 3
IEP
RGD
PMID:11485922
RGD:7327201
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Atp1a1
ATPase Na+/K+ transporting subunit alpha 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29702141
NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
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Atp2a1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
IMP
RGD
PMID:17630344
RGD:13782075
NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
treatment
ISO IEP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:10734148 PMID:28637456
RGD:13782080
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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Atp5f1d
ATP synthase F1 subunit delta
treatment
IEP
protein:decreased expression:myocardium (rat)
RGD
PMID:26109848 PMID:25305180
RGD:13792666 , RGD:13792676
NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929
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Bad
BCL2-associated agonist of cell death
treatment
IEP IDA
protein:increased expression, decreased serine phosphorylation:heart
RGD
PMID:15339931 PMID:23364609
RGD:2292700 , RGD:10053674
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bax
BCL2 associated X, apoptosis regulator
treatment
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:20026869 PMID:21223820 PMID:25547710 PMID:31583047
RGD:10054103 , RGD:13782178 , RGD:155230831
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
treatment
IEP IDA
RGD
PMID:16289365 PMID:23364609 PMID:20821058 PMID:31583047
RGD:1599484 , RGD:10053674 , RGD:11561911 , RGD:155230831
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
treatment
IDA
RGD
PMID:12668130
RGD:11035287
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Becn1
beclin 1
treatment
IDA ISO
RGD
PMID:20821058 PMID:20812860
RGD:11561911 , RGD:11561944
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Bid
BH3 interacting domain death agonist
IDA IEP
protein:increased cleavage:heart:
RGD
PMID:19940077 PMID:11934844
RGD:2317561 , RGD:13782263
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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Blk
BLK proto-oncogene, Src family tyrosine kinase
IEP
mRNA:increased expression:left ventricle (rat)
RGD
PMID:17562528
RGD:1642307
NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031
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Bnip3
BCL2 interacting protein 3
treatment
IMP IEP
protein:decreased expression:myocardium (human)
RGD
PMID:16645637 PMID:28661226
RGD:11561983 , RGD:155260328
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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Brd4
bromodomain containing 4
ISO
mRNA,protein:increased expression:heart
RGD
PMID:33982231
RGD:155883171
NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
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Btg2
BTG anti-proliferation factor 2
IEP
mRNA:increased expression:heart
RGD
PMID:12909328
RGD:2289075
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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C3
complement C3
IEP
protein:increased expression:myocardium
RGD
PMID:11560858
RGD:1582136
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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C5
complement C5
treatment
IDA IMP
RGD
PMID:9631876 PMID:23067403
RGD:1600666 , RGD:7411626
NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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Casp1
caspase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14998631
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp12
caspase 12
treatment
IEP ISO
protein:increased activity:myocardium CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:14998631 PMID:19406177 PMID:25547710
RGD:2311458 , RGD:13782178
NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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Casp3
caspase 3
treatment ameliorates
IMP ISO IEP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:14998631 PMID:18470603 PMID:29538428 PMID:30259997
RGD:2293314 , RGD:13782276 , RGD:329337366
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
treatment
ISO IEP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:14998631 PMID:29538428
RGD:13782276
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp8
caspase 8
ISO IEP
CTD Direct Evidence: marker/mechanism protein:increased activity:cardiomyocyte
CTD RGD
PMID:14998631 PMID:11934844
RGD:13782263
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
treatment ameliorates
ISO IEP
CTD Direct Evidence: marker/mechanism protein:increased activity:cardiomyocyte,endothelial cell
CTD RGD
PMID:14998631 PMID:11934844 PMID:29538428 PMID:30259997
RGD:13782263 , RGD:13782276 , RGD:329337366
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Casr
calcium-sensing receptor
IEP
protein:increased expression:ventricular myocardium (rat)
RGD
PMID:21766206
RGD:7205698
NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
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Cast
calpastatin
ameliorates
IEP ISO
human transcript overexpression in rat model
RGD
PMID:12482022 PMID:14519437
RGD:5683872 , RGD:405101692
NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659
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Cat
catalase
IEP ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:21600015 PMID:11510883
RGD:1581149
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cbl
Cbl proto-oncogene
severity
ISO
RGD
PMID:24583314
RGD:11251947
NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176
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Ccl2
C-C motif chemokine ligand 2
IEP ISO
mRNA:increased expression:heart (rat) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12087064 PMID:10908159
RGD:8549625
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccr2
C-C motif chemokine receptor 2
ISO
protein:decreased expression:monocyte:
RGD
PMID:15786508
RGD:4892017
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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Ccr5
C-C motif chemokine receptor 5
treatment
ISO IEP
protein:decreased expression:blood, monocyte (human)
RGD
PMID:15786508 PMID:23456481
RGD:4892017 , RGD:8552227
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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Cflar
CASP8 and FADD-like apoptosis regulator
treatment
IEP
RGD
PMID:18466417
RGD:11341714
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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Cnr1
cannabinoid receptor 1
IMP
RGD
PMID:18771032
RGD:2316217
NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
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Cnr2
cannabinoid receptor 2
IMP
RGD
PMID:17950273
RGD:2316224
NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
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Cobll1
cordon-bleu WH2 repeat protein-like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34355838
NCBI chr 3:49,753,260...49,915,168
Ensembl chr 3:49,753,262...49,915,194
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Crebbp
CREB binding protein
treatment
IEP
RGD
PMID:24338162
RGD:153352322
NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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Crp
C-reactive protein
IEP
protein:increased expression:serum
RGD
PMID:21122204
RGD:5128547
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Cx3cr1
C-X3-C motif chemokine receptor 1
ISO
protein:decreased expression:blood, monocyte
RGD
PMID:15786508
RGD:4892017
NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014
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Cxcl1
C-X-C motif chemokine ligand 1
IMP
RGD
PMID:11342480
RGD:5135269
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cxcl2
C-X-C motif chemokine ligand 2
IMP
RGD
PMID:11342480
RGD:5135269
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Cxcl6
C-X-C motif chemokine ligand 6
IMP
RGD
PMID:11342480
RGD:5135269
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
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Cybb
cytochrome b-245 beta chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19207477
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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Diablo
diablo, IAP-binding mitochondrial protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14998631
NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
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Dnm1l
dynamin 1-like
ameliorates
ISO
RGD
PMID:30259997
RGD:329337366
NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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Ece1
endothelin converting enzyme 1
IMP IEP
RGD
PMID:18586023 PMID:12193087
RGD:4892580 , RGD:7244160
NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
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Edn1
endothelin 1
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:15642760 PMID:16700825 PMID:18586023
RGD:4892580
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Ednra
endothelin receptor type A
IMP
RGD
PMID:18586023
RGD:4892580
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
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Ednrb
endothelin receptor type B
IMP
RGD
PMID:21048781
RGD:4892332
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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Egln1
egl-9 family hypoxia-inducible factor 1
susceptibility
ISO
RGD
PMID:20185832
RGD:11251775
NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777
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Ephx2
epoxide hydrolase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19834332
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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Esr1
estrogen receptor 1
IMP
RGD
PMID:18314151
RGD:4892299
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
ISO
RGD
PMID:18656630
RGD:5508820
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Fadd
Fas associated via death domain
treatment
ISO IEP
RGD
PMID:26038570 PMID:26948086
RGD:11341801 , RGD:13792504
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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Fas
Fas cell surface death receptor
treatment
IDA
RGD
PMID:21316771
RGD:8686424
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fis1
fission, mitochondrial 1
ameliorates
ISO
RGD
PMID:30259997
RGD:329337366
NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
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Gapdh
glyceraldehyde-3-phosphate dehydrogenase
treatment
IEP
RGD
PMID:27129213
RGD:11574725
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
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Gcg
glucagon
treatment
ISO
RGD
PMID:24125539
RGD:10402369
NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929
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Gdf11
growth differentiation factor 11
ISO
mRNA, protein:decreased expression:heart (mouse)
RGD
PMID:30765322
RGD:329849112
NCBI chr 7:1,311,732...1,325,211
Ensembl chr 7:1,311,732...1,320,725
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Gja1
gap junction protein, alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17445419
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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Glrx
glutaredoxin
IEP
mRNA:decreased expression:heart:
RGD
PMID:18163565
RGD:2306160
NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680
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Gpx3
glutathione peroxidase 3
ISO
RGD
PMID:11043918
RGD:401827843
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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Grk2
G protein-coupled receptor kinase 2
treatment susceptibility severity
IMP ISO IDA
associated with Diabetes Mellitus, Experimental associated with Hypertension protein:increased expression:heart, mitochondrion (mouse)
RGD
PMID:27865836 PMID:27601479 PMID:27296507 PMID:24170934 PMID:23467820
RGD:13513990 , RGD:13513993 , RGD:13513995 , RGD:13792704 , RGD:13792779
NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582
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Gsk3b
glycogen synthase kinase 3 beta
treatment
IDA IEP
RGD
PMID:20217242 PMID:29978610 PMID:26918336
RGD:5509104 , RGD:13792725 , RGD:13792772
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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Gsr
glutathione-disulfide reductase
treatment
IEP
RGD
PMID:24769323
RGD:10401892
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
H19
H19 imprinted maternally expressed transcript
ameliorates
ISO
RGD
PMID:31284127
RGD:158013771
NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
G
H2ax
H2A.X variant histone
treatment
IDA
RGD
PMID:23108649
RGD:8693739
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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Hdac3
histone deacetylase 3
ameliorates
ISO
RGD
PMID:33982231
RGD:155883171
NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
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Hif1a
hypoxia inducible factor 1 subunit alpha
treatment
IEP IDA ISO
mRNA:increased expression:heart protein:increased expression:myocardium CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:18549825 PMID:22050707 PMID:12189448 PMID:19727523 PMID:20170615
RGD:1626327 , RGD:5147885 , RGD:9068872
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Hmgb1
high mobility group box 1
treatment
IEP IDA ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21113057 PMID:23531454 PMID:19540007
RGD:10402066 , RGD:10402170
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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Hmox1
heme oxygenase 1
treatment
IDA IEP ISO
RGD
PMID:12709584 PMID:22179023 PMID:23921302
RGD:1598392 , RGD:10755573 , RGD:10755585
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hrh2
histamine receptor H 2
susceptibility
ISO
RGD
PMID:23467745
RGD:9685524
NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631
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Hrh3
histamine receptor H3
IDA
RGD
PMID:15076218
RGD:1626433
NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642
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Hsf1
heat shock transcription factor 1
ISO
RGD
PMID:22426029
RGD:10402789
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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Hspa1a
heat shock protein family A (Hsp70) member 1A
treatment
IEP
RGD
PMID:20501665
RGD:10003160
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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Hspa5
heat shock protein family A (Hsp70) member 5
treatment
IEP
RGD
PMID:24129401 PMID:25547710
RGD:11354962 , RGD:13782178
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Htra2
HtrA serine peptidase 2
ISO
protein:increased expression:myocardium, cytosol (mouse)
RGD
PMID:15611365
RGD:5688376
NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
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Icam1
intercellular adhesion molecule 1
IEP ISO
protein:increased expression:heart (rat) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12087064 PMID:20851484
RGD:4145348
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Il10
interleukin 10
treatment
IEP IDA
protein:increased expression:plasma
RGD
PMID:19275881 PMID:23840272
RGD:2311056 , RGD:7365001
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il17a
interleukin 17A
treatment
IMP
RGD
PMID:22030025
RGD:9068944
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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Il18
interleukin 18
ISO IDA
RGD
PMID:19164288 PMID:19805173
RGD:4889578 , RGD:4889400
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il18bp
interleukin 18 binding protein
ISO
mRNA:increased expression:heart
RGD
PMID:19164288 PMID:19805173
RGD:4889578 , RGD:4889400
NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963
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Il18rap
interleukin 18 receptor accessory protein
ISO
RGD
PMID:19164288
RGD:4889578
NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959
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Il1a
interleukin 1 alpha
treatment
ISO IEP
RGD
PMID:8576926 PMID:7622355
RGD:7794741 , RGD:7794764
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
treatment
IEP
mRNA:increased expression:heart
RGD
PMID:17134725 PMID:31583047
RGD:1626628 , RGD:155230831
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il1rl2
interleukin 1 receptor-like 2
IMP
compared to Wild Type in cardiopulmonary bypass model
RGD
PMID:32048631
RGD:126925167
NCBI chr 9:42,591,658...42,639,351
Ensembl chr 9:42,591,934...42,636,667
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Il1rl2tm1(Myh6-cre)Mhzh
interleukin 1 receptor-like 2; tm1 (Myh6-cre), Mhzh
IMP
compared to Wild Type in cardiopulmonary bypass model
RGD
PMID:32048631
RGD:126925167
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Il1rn
interleukin 1 receptor antagonist
ISO
rat model treated with human protein
RGD
PMID:22649318
RGD:7174360
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Il36rn
interleukin 36 receptor antagonist
IMP
RGD
PMID:32048631
RGD:126925167
NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016
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Il36rntm1(Myh6-cre)Mhzh
interleukin 36 receptor antagonist; tm1, Mhzh
IMP
RGD
PMID:32048631
RGD:126925167
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Il6
interleukin 6
treatment
IDA IEP
RGD
PMID:27087891 PMID:31583047
RGD:11062149 , RGD:155230831
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Il6r
interleukin 6 receptor
ISO
RGD
PMID:16056242
RGD:1625435
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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Inhba
inhibin subunit beta A
ISO
mRNA, protein:increased expression:heart (mouse)
RGD
PMID:30765322
RGD:329849112
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
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Irak1
interleukin-1 receptor-associated kinase 1
IEP
protein:increased activity:ventricle myocardium (rat)
RGD
PMID:15793310
RGD:1579809
NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521
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Irf9
interferon regulatory factor 9
ameliorates exacerbates
ISO
protein:increased expression:left ventricular free wall
RGD
PMID:25150882 PMID:25150882 PMID:25150882
RGD:125093742 , RGD:125093742 , RGD:125093742
NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236
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Jak2
Janus kinase 2
treatment
IMP
associated with Diabetes Mellitus, Experimental
RGD
PMID:23796350 PMID:23747931
RGD:8694332 , RGD:10403071
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Kcnj11
potassium inwardly-rectifying channel, subfamily J, member 11
ISO
RGD
PMID:17906066
RGD:7297046
NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082
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Kcnj8
potassium inwardly-rectifying channel, subfamily J, member 8
IDA
RGD
PMID:12234964
RGD:729109
NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603
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Klrk1
killer cell lectin like receptor K1
treatment
IMP
RGD
PMID:23953572
RGD:9685183
NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459
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Kng1
kininogen 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:2535056 PMID:7856280
NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
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Lep
leptin
IEP
RGD
PMID:21122204
RGD:5128547
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lepr
leptin receptor
IEP
mRNA:decreased expression:heart mRNA:altered expression:heart
RGD
PMID:15284063 PMID:17134725
RGD:5129123 , RGD:1626628
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Lum
lumican
IDA
RGD
PMID:11348051
RGD:1582122
NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793
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Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
treatment
IEP ISO
protein:increased expression:heart
RGD
PMID:20821058 PMID:20812860
RGD:11561911 , RGD:11561944
NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
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Map2k6
mitogen-activated protein kinase kinase 6
ISO
RGD
PMID:14749328 PMID:15492008
RGD:7495840 , RGD:1582277
NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
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Map3k5
mitogen-activated protein kinase kinase kinase 5
treatment
IEP
RGD
PMID:31583047
RGD:155230831
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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Mapk1
mitogen activated protein kinase 1
treatment
IDA
RGD
PMID:15653762 PMID:25345742
RGD:1582282 , RGD:13800900
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk14
mitogen activated protein kinase 14
ISO
RGD
PMID:14749328
RGD:7495840
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mapk3
mitogen activated protein kinase 3
treatment
IEP IDA
RGD
PMID:29741915 PMID:28814571 PMID:25345742
RGD:13800564 , RGD:13800874 , RGD:13800900
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
treatment
IDA IEP
RGD
PMID:15309413 PMID:12883833 PMID:31583047
RGD:1582311 , RGD:1582312 , RGD:155230831
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mb
myoglobin
ISO IDA
RGD
PMID:15132981 PMID:11972171
RGD:1582385 , RGD:1582431
NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
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Mbl1
mannose binding lectin 1
IDA ISO IMP
RGD
PMID:11560858 PMID:15972690 PMID:20216929
RGD:1582136 , RGD:1582131 , RGD:4889154
NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174
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Mbl2
mannose binding lectin 2
treatment
ISO
RGD
PMID:25482922
RGD:11530049
NCBI chr 1:228,016,439...228,024,736
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Mdm2
MDM2 proto-oncogene
IEP
protein:increased serine phosphorylation:heart ventricle (rat)
RGD
PMID:14644432
RGD:2317401
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Mfn2
mitofusin 2
treatment
IEP
RGD
PMID:24721408
RGD:13204835
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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Mir1
microRNA 1
treatment
IMP
RGD
PMID:29741915
RGD:13800564
NCBI chr18:1,887,537...1,887,623
G
Mir10a
microRNA 10a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr10:81,283,171...81,283,280
Ensembl chr10:81,283,171...81,283,280
G
Mir10b
microRNA 10b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 3:59,628,438...59,628,546
Ensembl chr 3:59,628,438...59,628,546
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Mir126a
microRNA 126a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 3:9,415,063...9,415,180
Ensembl chr 3:9,415,063...9,415,180
G
Mir134
microRNA 134
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 6:128,748,908...128,748,980
G
Mir137
microRNA 137
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 2:206,480,881...206,480,982
Ensembl chr 2:206,480,884...206,480,985
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Mir140
microRNA 140
exacerbates
ISO
miRNA:increased expression:heart, endothelial cells (mouse)
RGD
PMID:30259997 PMID:31792649
RGD:329337366 , RGD:329337374
NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675
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Mir142
microRNA 142
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr10:72,557,864...72,557,950
Ensembl chr10:72,557,857...72,557,967
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Mir145
microRNA 145
treatment
IEP
RNA:decreased expression:heart
RGD
PMID:31583047 PMID:33658472
RGD:155230831 , RGD:329955358
NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727
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Mir146b
microRNA 146b
IEP
miRNA:increased expression:heart (rat)
RGD
PMID:19380620
RGD:155882541
NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525
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Mir181c
microRNA 181c
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628
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Mir183
microRNA 183
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 4:58,788,614...58,788,723
Ensembl chr 4:58,788,614...58,788,723
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Mir186
microRNA 186
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 2:246,582,806...246,582,891
Ensembl chr 2:246,582,806...246,582,891
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Mir188
microRNA 188
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr X:15,247,715...15,247,794
Ensembl chr X:15,247,715...15,247,794
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Mir193a
microRNA 193a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454
G
Mir196b
microRNA 196b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 4:81,330,487...81,330,571
Ensembl chr 4:81,330,487...81,330,571
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Mir206
microRNA 206
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332
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Mir20b
microRNA 20b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr X:132,422,211...132,422,282
Ensembl chr X:132,422,211...132,422,282
G
Mir21
microRNA 21
exacerbates
ISO IEP
CTD Direct Evidence: marker/mechanism miRNA:increased expression:heart (rat)
CTD RGD
PMID:22050707 PMID:24825878 PMID:19380620
RGD:41404665 , RGD:155882541
NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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Mir210
microRNA 210
sexual_dimorphism
IEP ISO
miRNA:increased expression:myocardium (human)
RGD
PMID:28661226 PMID:35296158
RGD:155260328 , RGD:155663666
NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454
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Mir222
microRNA 222
ameliorates
ISO
RGD
PMID:25863248
RGD:152025190
NCBI chr X:3,428,904...3,429,006
Ensembl chr X:3,428,904...3,429,006
G
Mir23b
microRNA 23b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr17:1,813,667...1,813,763
Ensembl chr17:1,813,667...1,813,763
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Mir26a
microRNA 26a
treatment
IEP
RGD
PMID:29978610
RGD:13792725
NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378
G
Mir27a
microRNA 27a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917
G
Mir27b
microRNA 27b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529
G
Mir28
microRNA 28
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr11:75,975,523...75,975,608
Ensembl chr11:75,975,523...75,975,608
G
Mir296
microRNA 296
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 3:163,051,838...163,051,915
Ensembl chr 3:163,051,838...163,051,915
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Mir301b
microRNA 301b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr11:83,879,816...83,879,893
Ensembl chr11:83,879,816...83,879,893
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Mir30a
microRNA 30a
treatment
IEP
RGD
PMID:25137026
RGD:35673319
NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670
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Mir30c1
microRNA 30c-1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:34217758
NCBI chr 5:134,349,237...134,349,325
Ensembl chr 5:134,349,237...134,349,325
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Mir320a
microRNA 320a
treatment ameliorates
IMP ISO
RGD
PMID:27175593 PMID:19380620 PMID:30840298 PMID:25268616
RGD:155882540 , RGD:155882541 , RGD:155882546 , RGD:155882578
NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473
G
Mir330
microRNA 330
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 1:78,833,178...78,833,274
Ensembl chr 1:78,833,178...78,833,274
G
Mir331
microRNA 331
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 7:28,527,390...28,527,485
Ensembl chr 7:28,527,390...28,527,485
G
Mir337
microRNA 337
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 6:128,538,903...128,538,999
Ensembl chr 6:128,538,902...128,538,998
G
Mir346
microRNA 346
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr16:10,218,118...10,218,215
Ensembl chr16:10,218,118...10,218,215
G
Mir34c
microRNA 34c
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 8:51,409,726...51,409,802
Ensembl chr 8:51,409,726...51,409,802
G
Mir361
microRNA 361
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr X:78,246,206...78,246,275
Ensembl chr X:78,246,206...78,246,275
G
Mir375
microRNA 375
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985
G
Mir411
microRNA 411
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 6:128,723,189...128,723,264
Ensembl chr 6:128,723,184...128,723,279
G
Mir429
microRNA 429
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 5:166,647,459...166,647,543
Ensembl chr 5:166,647,459...166,647,543
G
Mir433
microRNA 433
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 6:128,545,119...128,545,211
Ensembl chr 6:128,545,112...128,545,217
G
Mir451a
microRNA 451a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr10:62,961,520...62,961,591
Ensembl chr10:62,961,520...62,961,591
G
Mir494
microRNA 494
ameliorates
ISO
RGD
PMID:33982231 PMID:20837890 PMID:20837890
RGD:155883171 , RGD:155883174 , RGD:155883174
NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793
G
Mir500
microRNA 500
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr X:15,258,778...15,258,857
Ensembl chr X:15,258,768...15,258,859
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Mir503
microRNA 503
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr X:132,806,303...132,806,373
Ensembl chr X:132,806,303...132,806,373
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Mir532
microRNA 532
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr X:15,247,315...15,247,393
Ensembl chr X:15,247,315...15,247,393
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Mir542
microRNA 542
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr X:132,802,623...132,802,701
Ensembl chr X:132,802,623...132,802,701
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Mir582
microRNA 582
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 2:40,928,571...40,928,651
Ensembl chr 2:40,928,571...40,928,651
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Mir598
microRNA 598
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr15:37,962,692...37,962,770
Ensembl chr15:37,962,692...37,962,771
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Mir743a
microRNA 743a
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr X:145,402,692...145,402,767
Ensembl chr X:145,402,692...145,402,767
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Mirlet7i
microRNA let-7i
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571
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Mki67
marker of proliferation Ki-67
IDA
RGD
PMID:22405128
RGD:6483543
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mmp1
matrix metallopeptidase 1
ISO IEP
RGD
PMID:12892382 PMID:17996137
RGD:1582539 , RGD:7207397
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp2
matrix metallopeptidase 2
treatment
ISO IEP
RGD
PMID:16699069 PMID:23889688
RGD:1582614 , RGD:8657084
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mstn
myostatin
ISO
mRNA, protein:increased expression:heart (mouse)
RGD
PMID:30765322
RGD:329849112
NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933
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Myd88
MYD88, innate immune signal transduction adaptor
IDA
RGD
PMID:14962484
RGD:1302746
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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Ncl
nucleolin
IEP
protein:decreased expression:heart
RGD
PMID:23594402
RGD:9686384
NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
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Ndufs1
NADH:ubiquinone oxidoreductase core subunit S1
treatment
IDA
RGD
PMID:21700931
RGD:13801200
NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893
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Nfe2l1
NFE2 like bZIP transcription factor 1
treatment
IEP
RGD
PMID:20501665
RGD:10003160
NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318
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Nfe2l2
NFE2 like bZIP transcription factor 2
ISO
RGD
PMID:24915518
RGD:10412738
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkbia
NFKB inhibitor alpha
treatment
IDA
RGD
PMID:19304943
RGD:10413871
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nos2
nitric oxide synthase 2
IEP ISO
mRNA:decreased expression:heart (rat) CTD Direct Evidence: marker/mechanism|therapeutic
CTD RGD
PMID:12003803 PMID:12087064 PMID:14990356 PMID:19207477 PMID:20828608 PMID:21844074 More...
RGD:5509098
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nos3
nitric oxide synthase 3
treatment
IEP IMP ISO IDA
CTD Direct Evidence: therapeutic
CTD RGD
PMID:12354446 PMID:20828747 PMID:18390819 PMID:29299201 PMID:29274587
RGD:4891991 , RGD:2292091 , RGD:13503347 , RGD:13504684
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Nox1
NADPH oxidase 1
IEP
mRNA:increased expression:heart
RGD
PMID:33658472
RGD:329955358
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
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Nppb
natriuretic peptide B
IDA
RGD
PMID:21168723
RGD:5685663
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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Nppc
natriuretic peptide C
IDA
RGD
PMID:15337698
RGD:1580149
NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251
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Npr3
natriuretic peptide receptor 3
IDA
RGD
PMID:15337698
RGD:1580149
NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
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Npy1r
neuropeptide Y receptor Y1
IEP
mRNA:decreased expression:heart left ventricle
RGD
PMID:17562528
RGD:1642307
NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759
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Olr1
oxidized low density lipoprotein receptor 1
treatment
IMP
RGD
PMID:12384456
RGD:628368
NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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Oprd1
opioid receptor, delta 1
IDA
RGD
PMID:12136724
RGD:2316590
NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
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Oxt
oxytocin/neurophysin I prepropeptide
IMP
RGD
PMID:19234577
RGD:2304087
NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
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P2ry12
purinergic receptor P2Y12
ISO
RGD
PMID:20431845
RGD:6480645
NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361
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Parp1
poly (ADP-ribose) polymerase 1
ISO
RGD
PMID:9670921 PMID:23598272
RGD:5683917 , RGD:11073735
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pawr
pro-apoptotic WT1 regulator
treatment
IMP
RGD
PMID:18055876
RGD:9835369
NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
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Pdia3
protein disulfide isomerase family A, member 3
IEP
RGD
PMID:12872233
RGD:1624250
NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
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Pecam1
platelet and endothelial cell adhesion molecule 1
IMP
RGD
PMID:8989147
RGD:2311662
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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Phlda3
pleckstrin homology-like domain, family A, member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34351043
NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
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Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
ISO
RGD
PMID:20179753
RGD:6482687
NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
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Plcd1
phospholipase C, delta 1
IDA
protein:altered activity
RGD
PMID:12623065
RGD:1304368
NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186
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Pld2
phospholipase D2
IDA
protein:altered activity:sarcolemma, sarcoplasmic reticulum, heart left ventricle
RGD
PMID:15752718
RGD:2299906
NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
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Pln
phospholamban
treatment
IDA ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:10734148 PMID:21934351
RGD:7327186
NCBI chr20:32,629,537...32,639,559
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Ppara
peroxisome proliferator activated receptor alpha
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16411023
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Ppard
peroxisome proliferator-activated receptor delta
IDA
RGD
PMID:19997057
RGD:2324876
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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Pparg
peroxisome proliferator-activated receptor gamma
ISO
RGD
PMID:18562925
RGD:2301853
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppargc1a
PPARG coactivator 1 alpha
treatment
ISO
RGD
PMID:19096023
RGD:10059669
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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Prkaa2
protein kinase AMP-activated catalytic subunit alpha 2
treatment
IEP
RGD
PMID:20501665
RGD:10003160
NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
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Prkcb
protein kinase C, beta
IDA
RGD
PMID:15878997
RGD:1625520
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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Prkcd
protein kinase C, delta
IEP
protein:decreased expression:heart
RGD
PMID:17322024
RGD:1642542
NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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Prkd1
protein kinase D1
ameliorates
ISO
RGD
PMID:24345679
RGD:307727199
NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042
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Prkg1
protein kinase cGMP-dependent 1
treatment
IMP
RGD
PMID:18332860 PMID:19845676
RGD:7777120 , RGD:7777130
NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
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Procr
protein C receptor
treatment
IDA
RGD
PMID:26994471
RGD:13515126
NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903
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Pten
phosphatase and tensin homolog
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:19038262 PMID:20951693
RGD:127285611
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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Ptger3
prostaglandin E receptor 3
treatment
IMP
RGD
PMID:10193764
RGD:10043342
NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
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Ptgs2
prostaglandin-endoperoxide synthase 2
IMP
RGD
PMID:17660401
RGD:2300261
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rap1a
RAP1A, member of RAS oncogene family
treatment
IDA
RGD
PMID:20501665
RGD:10003160
NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
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Rela
RELA proto-oncogene, NF-kB subunit
treatment
IDA IEP
protein:altered localization:nucleus
RGD
PMID:18636044 PMID:31583047
RGD:2298773 , RGD:155230831
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rhoa
ras homolog family member A
IEP
protein:altered localization:heart
RGD
PMID:17322412
RGD:1642967
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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Rnf41
ring finger protein 41
severity
ISO
RGD
PMID:21312039
RGD:401827146
NCBI chr 7:838,160...876,869
Ensembl chr 7:838,203...865,511
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Rnls
renalase, FAD-dependent amine oxidase
ISO
RGD
PMID:21178975 PMID:21178975
RGD:7327174 , RGD:7327174
NCBI chr 1:231,037,481...231,309,855
Ensembl chr 1:231,037,486...231,309,823
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S100b
S100 calcium binding protein B
IEP
mRNA, protein:increased expression:myocardium
RGD
PMID:21663912
RGD:5508825
NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
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Selp
selectin P
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12087064 PMID:21146547
RGD:6480105
NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
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Serpina3n
serpin family A member 3N
ISO
RGD
PMID:7562495
RGD:5147423
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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Serpine1
serpin family E member 1
treatment
IDA
RGD
PMID:26958805
RGD:11073621
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Serping1
serpin family G member 1
treatment
ISO
RGD
PMID:16942749
RGD:8661647
NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
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Sfrp2
secreted frizzled-related protein 2
IEP
RGD
PMID:19109969
RGD:4107088
NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063
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Sh2b3
SH2B adaptor protein 3
IMP
RGD
PMID:25628389
RGD:12904914
NCBI chr12:34,731,934...34,753,617
Ensembl chr12:34,731,911...34,753,616
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Sh2b3em2Mcwi
SH2B adaptor protein 3; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:25628389
RGD:12904914
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Shh
sonic hedgehog signaling molecule
IEP
protein:increased expression:heart
RGD
PMID:18228117
RGD:2306299
NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
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Sirt1
sirtuin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21060073
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Slc25a4
solute carrier family 25 member 4
treatment
IEP
RGD
PMID:24126566
RGD:9681554
NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
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Slc2a1
solute carrier family 2 member 1
IEP
RGD
PMID:10336852
RGD:12879857
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Slc2a4
solute carrier family 2 member 4
IEP
RGD
PMID:10336852
RGD:12879857
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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Slc8a1
solute carrier family 8 member A1
IDA IMP ISO
protein:increased activity:cardiac muscle cell CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:15215644 PMID:17267548 PMID:17822695
RGD:1642729 , RGD:1642716
NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
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Slc9a1
solute carrier family 9 member A1
IMP
RGD
PMID:22803959
RGD:6771238
NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
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Smad1
SMAD family member 1
ISO
RGD
PMID:15911698
RGD:1643233
NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
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Smad3
SMAD family member 3
treatment
IDA
RGD
PMID:22913380
RGD:12903950
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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Smad4
SMAD family member 4
treatment
IEP
RGD
PMID:22913380
RGD:12903950
NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
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Sod1
superoxide dismutase 1
treatment
ISO IDA
human protein in a rat model
RGD
PMID:19277497 PMID:23629152 PMID:12668130
RGD:8655884 , RGD:8655965 , RGD:11035287
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
treatment
ISO
RGD
PMID:11864929 PMID:12668130
RGD:1581222 , RGD:11035287
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sord
sorbitol dehydrogenase
IEP ISO
protein:increased activity:heart CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:18549825 PMID:14525943
RGD:1601364
NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
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Spp1
secreted phosphoprotein 1
ISO
RGD
PMID:15165989
RGD:1581342
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Stat1
signal transducer and activator of transcription 1
IDA
protein:increased phosphorylation:heart
RGD
PMID:16935931
RGD:1600091
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Stat3
signal transducer and activator of transcription 3
treatment
IDA
RGD
PMID:23796350
RGD:8694332
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Suv39h1
SUV39H1 histone lysine methyltransferase
treatment
IDA
associated with Diabetes Mellitus, Experimental
RGD
PMID:24752040
RGD:9586740
NCBI chr X:14,421,028...14,433,993
Ensembl chr X:14,421,109...14,433,982
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Tek
TEK receptor tyrosine kinase
IEP
mRNA, protein:increased expression:ventricle myocardium
RGD
PMID:12737621
RGD:1601505
NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
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Tfrc
transferrin receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18549825
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Tgfb1
transforming growth factor, beta 1
treatment
IEP
RGD
PMID:22913380
RGD:12903950
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Thbs1
thrombospondin 1
IEP
mRNA:increased expression:heart
RGD
PMID:16179730
RGD:2317960
NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
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Timp4
TIMP metallopeptidase inhibitor 4
IEP
protein:increased expression:blood
RGD
PMID:12707244
RGD:2290461
NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558
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Tlr2
toll-like receptor 2
IEP
RGD
PMID:19274437
RGD:2312688
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4
toll-like receptor 4
IDA
RGD
PMID:14962484
RGD:1302746
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tnc
tenascin C
IEP
RGD
PMID:20554738
RGD:4889599
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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Tnf
tumor necrosis factor
treatment
IEP
protein:increased expression:serum, heart:
RGD
PMID:24157164 PMID:31583047
RGD:7387274 , RGD:155230831
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnni3
troponin I3, cardiac type
ameliorates
ISO
RGD
PMID:30259997
RGD:329337366
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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Tp53
tumor protein p53
IEP
protein:increased expression:heart
RGD
PMID:18317410
RGD:2290554
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Txn1
thioredoxin 1
IEP
mRNA:decreased expression:heart
RGD
PMID:18045550
RGD:2306159
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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Txn2
thioredoxin 2
IEP
mRNA, protein:decreased expression:heart
RGD
PMID:18045550
RGD:2306159
NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
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Ucn
urocortin
IDA
RGD
PMID:15806110
RGD:1642783
NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950
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Ucp2
uncoupling protein 2
IEP
mRNA:increased expression:myocardium
RGD
PMID:19526854
RGD:2313528
NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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Ucp3
uncoupling protein 3
IEP
mRNA:increased expression:myocardium
RGD
PMID:19526854
RGD:2313528
NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
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Uts2
urotensin 2
IDA
RGD
PMID:17900760
RGD:2306836
NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237
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Uts2r
urotensin 2 receptor
IMP
RGD
PMID:17900760
RGD:2306836
NCBI chr10:106,438,092...106,439,252
Ensembl chr10:106,438,092...106,439,252
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Vcam1
vascular cell adhesion molecule 1
IEP
protein:increased expression:heart
RGD
PMID:23052973
RGD:7207792
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Vcan
versican
IEP
mRNA:increased expression:heart
RGD
PMID:16311904
RGD:1598497
NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
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Vdac1
voltage-dependent anion channel 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25488258
NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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Vdr
vitamin D receptor
ISO
mRNA,protein:increased expression, activity:heart:
RGD
PMID:25365634
RGD:13432076
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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Vegfa
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Xdh
xanthine dehydrogenase
IEP
RGD
PMID:3162724
RGD:13209131
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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Xiap
X-linked inhibitor of apoptosis
treatment
ISO IEP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:14998631 PMID:20501665
RGD:10003160
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
G
Yes1
YES proto-oncogene 1, Src family tyrosine kinase
ISO
mRNA,protein:increased expression:myocardium (mouse)
RGD
PMID:30259997
RGD:329337366
NCBI chr 9:113,200,256...113,275,942
Ensembl chr 9:113,200,256...113,299,837
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