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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Insulin Resistance
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Accession:DOID:9007692 term browser browse the term
Definition:Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
Synonyms:exact_synonym: Insulin Sensitivity
 narrow_synonym: Insulin Resistance Syndrome, Type A
 related_synonym: FATTY ACID-BINDING PROTEIN, INTESTINAL, POLYMORPHISM OF;   Insulin Resistance, Susceptibility To;   Serum hdl cholesterol level, modifier of
 primary_id: MESH:D007333;   RDO:0003504
 xref: EFO:0002614


show annotations for term's descendants           Sort by:
Insulin Resistance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-Coenzyme A carboxylase alpha treatment ISO RGD PMID:16485039 PMID:26394137 RGD:1625727, RGD:329955565 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477 		JBrowse link
G Acacb acetyl-Coenzyme A carboxylase beta treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:22658938 PMID:16485039 PMID:26394137 RGD:1625727, RGD:329955565 NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822 		JBrowse link
G Ace angiotensin I converting enzyme ISO GAD PMID:15118671 RGD:1331525 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Acp1 acid phosphatase 1, soluble IMP associated with Obesity RGD PMID:17353188 RGD:2313180 NCBI chr12:30,943,325...30,961,616
Ensembl chr12:30,943,325...30,961,588 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 ISO mRNA:decreased expression:subcutaneous adipose tissue RGD PMID:16788709 RGD:1625735 NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing treatment ISO associated with Hypertension
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:18931039 PMID:21484566 PMID:16041833 PMID:21872431 PMID:23089228 RGD:1599150, RGD:8695928, RGD:8695951 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adipor1 adiponectin receptor 1 resistance ISO associated with Diabetes Mellitus, Type 2;DNA:SNP: :-3881T>C RGD PMID:17285539 RGD:1625762 NCBI chr 1:134,343,116...134,361,089
Ensembl chr 1:134,343,116...134,361,089 		JBrowse link
G Adipor2 adiponectin receptor 2 treatment ISO RGD PMID:30225267 PMID:24797033 RGD:21406435, RGD:25824940 NCBI chr 6:119,330,111...119,394,489
Ensembl chr 6:119,330,111...119,394,665 		JBrowse link
G Adm adrenomedullin ISO CTD Direct Evidence: therapeutic CTD PMID:33491863 NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027 		JBrowse link
G Adora1 adenosine A1 receptor treatment ISO associated with Obesity RGD PMID:11703426 PMID:15220221 RGD:2313807, RGD:1625243 NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169 		JBrowse link
G Adra1b adrenergic receptor, alpha 1b susceptibility IAGP RGD PMID:14581480 RGD:1625772 NCBI chr11:43,665,432...43,792,076
Ensembl chr11:43,665,433...43,792,037 		JBrowse link
G Adrb2 adrenergic receptor, beta 2 ISO DNA:polymorphism: :p.R16G
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:19034036 PMID:15699455 PMID:11510954 RGD:1601125, RGD:1598757 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030 		JBrowse link
G Adrb3 adrenergic receptor, beta 3 no_association ISO DNA:missense mutation:cds:p.W64R rs4994 (human)
associated with Obesity;DNA:polymorphism: :p.W64R (human)		 RGD PMID:10421225 PMID:17299491 PMID:10582543 RGD:1559326, RGD:2313158, RGD:5684421 NCBI chr 8:27,715,804...27,720,833
Ensembl chr 8:27,715,804...27,740,644 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 ISO protein:increased expression:dorsal root ganglion, neuron RGD PMID:22357959 RGD:6903873 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Ahr aryl-hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25734695 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Ahsg alpha-2-HS-glycoprotein susceptibility IAGP
ISO		 protein:increased expression:plasma RGD PMID:17011519 PMID:16567827 RGD:1625793, RGD:1625794 NCBI chr16:22,710,793...22,718,193
Ensembl chr16:22,710,027...22,718,199 		JBrowse link
G Akt2 thymoma viral proto-oncogene 2 no_association ISO DNA:SNPs RGD PMID:17327441 RGD:1601155 NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial treatment ISO protein:altered expression, altered activity:liver (rat) RGD PMID:28688179 RGD:14981582 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase IMP RGD PMID:19787041 RGD:5509625 NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857 		JBrowse link
G Ankrd26 ankyrin repeat domain 26 IMP RGD PMID:18162531 RGD:9681744 NCBI chr 6:118,478,261...118,539,244
Ensembl chr 6:118,478,269...118,539,187 		JBrowse link
G Apln apelin ISO mRNA:increased expression:subcutaneous adipose tissue RGD PMID:17594060 RGD:1626170 NCBI chr  X:47,114,023...47,123,730
Ensembl chr  X:47,114,023...47,123,730 		JBrowse link
G Apoa2 apolipoprotein A-II IMP RGD PMID:11246886 RGD:2313957 NCBI chr 1:171,049,133...171,053,948
Ensembl chr 1:171,052,623...171,053,948 		JBrowse link
G Apoc1 apolipoprotein C-I ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:11723061 RGD:2313951 NCBI chr 7:19,423,405...19,426,584
Ensembl chr 7:19,423,406...19,426,585 		JBrowse link
G Apoc3 apolipoprotein C-III susceptibility
treatment		 IAGP
ISO		 RGD PMID:15734841 PMID:15007394 RGD:1601226, RGD:1580750 NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934 		JBrowse link
G Ar androgen receptor ISO associated with Polycystic Ovary Syndrome;DNA:repeat: :CAG
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:21444647 PMID:17332526 PMID:16793958 RGD:1601244, RGD:2306773 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Arg1 arginase, liver ISO protein:decreased activity:liver (rat) RGD PMID:20593143 RGD:4142796 NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382 		JBrowse link
G As3mt arsenite methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chr19:46,695,124...46,729,538
Ensembl chr19:46,695,897...46,729,538 		JBrowse link
G Atm ataxia telangiectasia mutated treatment ISO protein:decreased expression:muscle:
Associated with human immunodeficiency virus infectious disease, hepatitis C;DNA:SNP:intron: (rs11212617) (human) 		RGD PMID:18534819 PMID:23171036 RGD:8693659, RGD:126781688 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040 		JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide ISO mRNA:increased expression:skeletal muscle RGD PMID:14576983 RGD:1601252 NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631 		JBrowse link
G Bad BCL2-associated agonist of cell death ISO protein:decreased phosphorylation, increased dimerization, increased glycosylation:heart RGD PMID:21385329 RGD:10053645 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Bche butyrylcholinesterase ISO RGD PMID:17917325 RGD:2306776 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748 		JBrowse link
G Bdkrb1 bradykinin receptor, beta 1 ISO RGD PMID:17618300 PMID:17988733 RGD:5129217, RGD:5129214 NCBI chr12:105,570,350...105,571,770
Ensembl chr12:105,569,344...105,571,687 		JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin ISO RGD PMID:25934999 RGD:11085488 NCBI chr19:8,814,831...8,826,047
Ensembl chr19:8,814,831...8,826,047 		JBrowse link
G C1ra complement component 1, r subcomponent A ISO protein:increased expression:adipocyte RGD PMID:17244723 RGD:1600551 NCBI chr 6:124,489,580...124,500,399
Ensembl chr 6:124,489,364...124,500,402 		JBrowse link
G C1rb complement component 1, r subcomponent B ISO protein:increased expression:adipocyte RGD PMID:17244723 RGD:1600551 NCBI chr 6:124,547,389...124,558,003
Ensembl chr 6:124,547,253...124,558,130 		JBrowse link
G C3 complement component 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18615583 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Capn10 calpain 10 ISO DNA:SNP:intron:rs3792267 (human) RGD PMID:11018080 RGD:7247736 NCBI chr 1:92,862,130...92,875,670
Ensembl chr 1:92,862,098...92,875,663 		JBrowse link
G Casp1 caspase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22325453 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 treatment ISO RGD PMID:29748970 RGD:13782289 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 ISO RGD PMID:29748970 RGD:13782289 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Cat catalase ISO associated with Obesity RGD PMID:19188683 RGD:5130761 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cblb Casitas B-lineage lymphoma b IAGP RGD PMID:17601987 RGD:2314038 NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 susceptibility ISO
IMP		 associated with Obesity in Diabetes;DNA:polymorphism:promoter:-2518A>G (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:29035695 PMID:18762729 PMID:22983634 RGD:2306985, RGD:8548844 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Cd163 CD163 antigen exacerbates ISO CTD Direct Evidence: marker/mechanism
associated with hepatitis C, human immunodeficiency virus infectious disease;protein:increased expression:blood plasma (human)		 CTD
RGD		 PMID:29035695 PMID:26554542 RGD:149735574 NCBI chr 6:124,281,596...124,307,488
Ensembl chr 6:124,281,615...124,307,486 		JBrowse link
G Cd36 CD36 molecule ISO
IMP		 associated with Diabetes Mellitus, Type 2
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:14640889 PMID:11175782 PMID:15231693 PMID:12923231 PMID:25477422 RGD:68930, RGD:2307217, RGD:11040926, RGD:11041132 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cd40 CD40 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:29035695 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cd68 CD68 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:29035695 NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979 		JBrowse link
G Cers1 ceramide synthase 1 ameliorates IMP RGD PMID:30605666 RGD:156431060 NCBI chr 8:70,768,425...70,784,238
Ensembl chr 8:70,768,425...70,784,242 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO associated with Obesity RGD PMID:19553924 RGD:2314662 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Cntf ciliary neurotrophic factor TAS possible therapeutic agent RGD PMID:16675997 RGD:1626122 NCBI chr19:12,740,892...12,742,996
Ensembl chr19:12,741,024...12,742,996 		JBrowse link
G Coq2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase ISO associated with obesity RGD PMID:26296322 RGD:10755343 NCBI chr 5:100,802,589...100,822,154
Ensembl chr 5:100,802,589...100,823,006 		JBrowse link
G Cpb2 carboxypeptidase B2 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression, increased activity:plasma RGD PMID:11836301 RGD:2313645 NCBI chr14:75,479,727...75,520,995
Ensembl chr14:75,479,727...75,520,995 		JBrowse link
G Cpe carboxypeptidase E ISO CTD Direct Evidence: marker/mechanism CTD PMID:15358678 NCBI chr 8:65,045,576...65,146,143
Ensembl chr 8:65,045,576...65,146,088 		JBrowse link
G Cst3 cystatin C ISO associated with Diabetes Mellitus, Non-Insulin Dependent; protein:increased expression:serum (human) RGD PMID:19765773 RGD:2314305 NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612 		JBrowse link
G Ctf1 cardiotrophin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21803294 NCBI chr 7:127,311,872...127,317,360
Ensembl chr 7:127,311,908...127,317,364 		JBrowse link
G Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1 ISO DNA:SNP:CDS: rs12794714|rs10766197 (human) RGD PMID:34906413 RGD:401900724 NCBI chr 7:114,149,358...114,162,283
Ensembl chr 7:114,148,917...114,162,207 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 treatment ISO RGD PMID:26394137 RGD:329955565 NCBI chr 7:98,802,870...98,831,920
Ensembl chr 7:98,802,865...98,831,926 		JBrowse link
G Dio2 deiodinase, iodothyronine, type II ISO DNA:SNP: :rs225014, p.T92A (human) RGD PMID:11872697 RGD:2313698 NCBI chr12:90,691,326...90,705,812
Ensembl chr12:90,691,326...90,705,812 		JBrowse link
G Drd1 dopamine receptor D1 ISO associated with Obesity;protein:increased serine phosphorylation:renal proximal tubule RGD PMID:15798088 RGD:2302119 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724 		JBrowse link
G Ech1 enoyl coenzyme A hydratase 1, peroxisomal treatment IDA RGD PMID:31961704 RGD:21408561 NCBI chr 7:28,524,763...28,531,664
Ensembl chr 7:28,524,642...28,531,672 		JBrowse link
G Egfr epidermal growth factor receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22238402 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISO DNA:polymorphism:K121Q
ClinVar Annotator: match by term: Insulin resistance, susceptibility to		 ClinVar
RGD		 PMID:10480624 PMID:11739459 PMID:14671192 PMID:14988267 PMID:15001634 More... RGD:1601043 NCBI chr10:24,513,812...24,588,057
Ensembl chr10:24,513,812...24,588,057 		JBrowse link
G F7 coagulation factor VII severity ISO associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased activity:plasma (human) RGD PMID:9187410 RGD:2312406 NCBI chr 8:13,075,499...13,085,809
Ensembl chr 8:13,076,034...13,085,809 		JBrowse link
G Fabp2 fatty acid binding protein 2, intestinal no_association ISO DNA:SNP:CDS:p.A54T (human)
DNA:polymorphism:CDS:p.A54T (human)
DNA:polymorphism:CDS:amino acid A54T, in healthy, moderately overweight subjects in Baton Rouge
ClinVar Annotator: match by term: FATTY ACID-BINDING PROTEIN, INTESTINAL, POLYMORPHISM OF		 ClinVar
RGD		 PMID:7883976 PMID:9253345 PMID:10946885 PMID:10999802 PMID:12161503 More... RGD:1300314, RGD:1626400, RGD:1626407, RGD:1578456 NCBI chr 3:122,688,721...122,693,155
Ensembl chr 3:122,688,721...122,693,155 		JBrowse link
G Fabp3 fatty acid binding protein 3, muscle and heart severity IAGP RGD PMID:16249436 RGD:1578459 NCBI chr 4:130,202,531...130,209,256
Ensembl chr 4:130,202,388...130,209,256 		JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte ISO RGD PMID:17391165 RGD:1625407 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636 		JBrowse link
G Fanca Fanconi anemia, complementation group A IMP RGD PMID:22482891 RGD:11046266 NCBI chr 8:123,993,033...124,045,390
Ensembl chr 8:123,995,039...124,045,315 		JBrowse link
G Fancc Fanconi anemia, complementation group C IMP RGD PMID:22482891 RGD:11046266 NCBI chr13:63,452,519...63,645,126
Ensembl chr13:63,432,857...63,645,092 		JBrowse link
G Fas Fas cell surface death receptor treatment ISO associated with hypothalamic disease RGD PMID:29522769 RGD:13792596 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasn fatty acid synthase treatment ISO RGD PMID:26394137 RGD:329955565 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Fgf15 fibroblast growth factor 15 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28673684 NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690 		JBrowse link
G Fis1 fission, mitochondrial 1 ISO protein:increased expression:liver (rat) RGD PMID:24663492 RGD:12453042 NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088 		JBrowse link
G Foxc2 forkhead box C2 ISO DNA:polymorphism:5'ut:-512C>T RGD PMID:12453913 RGD:1601219 NCBI chr 8:121,842,910...121,845,634
Ensembl chr 8:121,842,910...121,845,634 		JBrowse link
G Foxo1 forkhead box O1 ISO mRNA:increased expression:adipose tissue: RGD PMID:16041833 RGD:1599150 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642 		JBrowse link
G Fto FTO alpha-ketoglutarate dependent dioxygenase ISO associated with diabetes mellitus;DNA:SNP: :rs9939609 (human)
associated with obesity;DNA:SNP:intron:rs17817449 (human)
DNA:SNPs, haplotype: :rs1121980, rs1558902, rs9939609 (human)
mRNA, protein:increased expression:liver		 RGD PMID:30273662 PMID:21919686 PMID:20075932 PMID:35945320 RGD:329812018, RGD:329812040, RGD:329853775, RGD:329951016 NCBI chr 8:92,039,995...92,395,061
Ensembl chr 8:92,040,153...92,395,067 		JBrowse link
G Fxn frataxin ISO DNA:repeats:intron:GAA (human) RGD PMID:10969848 RGD:2307049 NCBI chr19:24,236,909...24,257,954
Ensembl chr19:24,238,817...24,257,969 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked ISO associated with Obesity;protein:increased expression:pancreas RGD PMID:23015612 RGD:10449129 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gck glucokinase ISO protein:increased expression:pancreatic islet RGD PMID:19039094 RGD:7488970 NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081 		JBrowse link
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 ISO RGD PMID:11118009 RGD:1625423 NCBI chr 6:87,019,828...87,069,189
Ensembl chr 6:87,019,828...87,069,179 		JBrowse link
G Gh growth hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:21559284 NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691 		JBrowse link
G Gnas GNAS complex locus ISO CTD Direct Evidence: marker/mechanism CTD PMID:17062894 NCBI chr 2:174,126,113...174,188,537
Ensembl chr 2:174,126,113...174,188,537 		JBrowse link
G Gnb3 guanine nucleotide binding protein (G protein), beta 3 ISO DNA:polymorphism: :825C>T (human) RGD PMID:12624279 RGD:1580411 NCBI chr 6:124,811,203...124,817,238
Ensembl chr 6:124,811,203...124,817,238 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial treatment ISO RGD PMID:26394137 RGD:329955565 NCBI chr19:55,056,067...55,115,666
Ensembl chr19:55,055,700...55,115,670 		JBrowse link
G Gpr17 G protein-coupled receptor 17 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34144038 NCBI chr18:32,076,052...32,082,925
Ensembl chr18:32,076,050...32,082,689 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma		 CTD
RGD		 PMID:19270708 PMID:24361363 RGD:401827920 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IDA RGD PMID:15994203 RGD:1625791 NCBI chr19:4,336,029...4,356,356
Ensembl chr19:4,336,029...4,356,250 		JBrowse link
G Gsta4 glutathione S-transferase, alpha 4 ISO mRNA:decreased expression:omental fat pad, subcutaneous adipose tissue (human) RGD PMID:20150287 RGD:5687771 NCBI chr 9:78,099,248...78,116,631
Ensembl chr 9:78,090,056...78,116,631 		JBrowse link
G Gys1 glycogen synthase 1, muscle susceptibility ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:missense mutation:exon:p.M416V (human) RGD PMID:9267990 RGD:2313176 NCBI chr 7:45,084,263...45,106,041
Ensembl chr 7:45,084,268...45,106,043 		JBrowse link
G Hamp hepcidin antimicrobial peptide ISO mRNA:decreased expression:liver RGD PMID:17350134 RGD:1601515 NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457 		JBrowse link
G Hmga1 high mobility group AT-hook 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23512162 NCBI chr17:27,774,798...27,782,649
Ensembl chr17:27,775,471...27,782,648 		JBrowse link
G Hmox1 heme oxygenase 1 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD		 PMID:18375438 PMID:19171794 PMID:12941774 RGD:1601621 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hnf1a HNF1 homeobox A ISO mRNA:decreased expression:adipocyte
ClinVar Annotator: match by term: SERUM HDL CHOLESTEROL LEVEL, MODIFIER OF		 ClinVar
RGD		 PMID:8945470 PMID:9112026 PMID:9287053 PMID:9604876 PMID:10333057 More... RGD:1601482 NCBI chr 5:115,087,039...115,109,121
Ensembl chr 5:115,087,039...115,109,153 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21786805 NCBI chr 1:192,903,917...192,946,345
Ensembl chr 1:192,903,942...192,946,383 		JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) ISO RGD PMID:18948349 RGD:10402862 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402 		JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A ISO associated with Peripheral Vascular Diseases RGD PMID:17062970 RGD:1624367 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO associated with Obesity;protein:increased secretion:plasma (human)
protein:increased expression:serum		 RGD PMID:11782876 PMID:19394054 RGD:1625753, RGD:2313467 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Igf2bp2 insulin-like growth factor 2 mRNA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chr16:21,877,759...21,982,049
Ensembl chr16:21,877,759...21,982,049 		JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:17726072 NCBI chr17:25,096,818...25,100,985
Ensembl chr17:25,084,971...25,100,984 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:22537059 PMID:17259371 RGD:1626479 NCBI chr 1:72,863,650...72,891,633
Ensembl chr 1:72,863,662...72,891,633 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 ISO RGD PMID:17237715 RGD:2313762 NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923 		JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 ISO human transgene overexpressed in mouse brain RGD PMID:15889232 RGD:2301717 NCBI chr15:102,052,621...102,057,947
Ensembl chr15:102,052,797...102,057,946 		JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 ISO
IMP		 protein:increased expression:serum
associated with metabolic dysfunction-associated steatotic liver disease		 RGD PMID:16873698 PMID:31397492 RGD:1626516, RGD:401960873 NCBI chr 5:77,497,092...77,555,892
Ensembl chr 5:77,497,087...77,555,888 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta treatment ISO
IMP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:29036520 PMID:19073766 PMID:11533494 RGD:7495768, RGD:10045961 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Il18 interleukin 18 treatment ISO
IMP		 associated with Graves Disease RGD PMID:23257837 PMID:16732281 RGD:8655938, RGD:14695532 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta treatment IEP
ISO		 associated with Obesity;mRNA:increased expression:adipose tissue
associated with hypothalamic disease		 RGD PMID:16865359 PMID:29522769 RGD:1626632, RGD:13792596 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 ISO associated with Diabetes Mellitus, Experimental; protein:increased expression:extracellular space (rat)
mRNA:increased expression:islet of Langerhans		 RGD PMID:19328014 PMID:21826222 RGD:2307252, RGD:10402828 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Il6ra interleukin 6 receptor, alpha ISO protein:decreased expression:serum RGD PMID:14962155 RGD:1625431 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503 		JBrowse link
G Il7 interleukin 7 ISO CTD Direct Evidence: therapeutic CTD PMID:20376352 NCBI chr 3:7,637,088...7,678,820
Ensembl chr 3:7,635,054...7,678,820 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 ISO associated with Metabolic Syndrome X RGD PMID:17327370 PMID:12453826 RGD:2312440, RGD:2312442 NCBI chr 7:101,471,839...101,487,419
Ensembl chr 7:101,471,839...101,487,436 		JBrowse link
G Ins1 insulin I EXP CTD Direct Evidence: marker/mechanism CTD PMID:19586609 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ins2 insulin II ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:11522680 PMID:24648896 PMID:25796170 PMID:33651899 PMID:3322910 RGD:2311112 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Insr insulin receptor treatment
disease_progression		 IMP
ISO		 CTD Direct Evidence: marker/mechanism
mRNA, protein:decreased expression:liver (rat)
ClinVar Annotator: match by term: Insulin resistance | ClinVar Annotator: match by term: Insulin-resistance syndrome type A		 CTD
ClinVar
RGD		 PMID:1314826 PMID:1644241 PMID:1890161 PMID:1963473 PMID:1971035 More... RGD:1302523, RGD:10403037, RGD:11529553 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617 		JBrowse link
G Irs1 insulin receptor substrate 1 ISO DNA:polymorphism:exon:G972R
ClinVar Annotator: match by term: Insulin resistance, susceptibility to
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
RGD		 PMID:1311924 PMID:7623569 PMID:8104271 PMID:8647950 PMID:10084586 More... RGD:1624973 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137 		JBrowse link
G Irs2 insulin receptor substrate 2 ISO DNA:polymorphism:exon:G1057D
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:25808216 PMID:15811564 RGD:1625025 NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458 		JBrowse link
G Itgam integrin alpha M ISO CTD Direct Evidence: marker/mechanism CTD PMID:29035695 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9032110 NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188 		JBrowse link
G Kcnmb1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 ISO mRNA, protein:decreased expression:aorta, mesenteric artery RGD PMID:21425425 RGD:10412047 NCBI chr11:33,912,955...33,923,641
Ensembl chr11:33,913,013...33,923,641 		JBrowse link
G Klf11 Kruppel-like transcription factor 11 ISO RGD PMID:18505768 RGD:2311539 NCBI chr12:24,701,370...24,712,781
Ensembl chr12:24,701,273...24,712,788 		JBrowse link
G Klf14 Kruppel-like transcription factor 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29632379 NCBI chr 6:30,932,956...30,935,925
Ensembl chr 6:30,932,958...30,936,013 		JBrowse link
G Klk1 kallikrein 1 ISO RGD PMID:17272402 RGD:1641794 NCBI chr 7:43,874,784...43,879,046
Ensembl chr 7:43,874,784...43,879,042 		JBrowse link
G Lep leptin ISO protein:increased expression:plasma
associated with Obesity
DNA:nonsense mutation:cds:
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:10753628 PMID:11342529 PMID:24150608 PMID:29650965 PMID:19296906 More... RGD:5128697, RGD:2311127, RGD:8549777 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lepr leptin receptor ISO associated with Obesity;DNA:polymorphism: :p.K656N (human)
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :p.K656N (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:19452630 PMID:20567778 PMID:25367288 PMID:28611668 PMID:29988851 More... RGD:2311142, RGD:2311138, RGD:13432147 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Lipc lipase, hepatic ISO CTD Direct Evidence: marker/mechanism CTD PMID:15504970 NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508 		JBrowse link
G Lmna lamin A ISO ClinVar Annotator: match by term: Insulin-resistance syndrome type A ClinVar PMID:15919811 PMID:16478798 PMID:20848652 PMID:23785128 PMID:24033266 More... NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263 		JBrowse link
G Lpin1 lipin 1 ISO RGD PMID:17563064 RGD:1641822 NCBI chr12:16,585,670...16,697,020
Ensembl chr12:16,585,670...16,696,967 		JBrowse link
G Lpl lipoprotein lipase IAGP RGD PMID:18952837 RGD:2313300 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100 		JBrowse link
G Lta lymphotoxin A no_association ISO DNA:polymorphism RGD PMID:9245742 RGD:1625035 NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 treatment ISO associated with polycystic ovary syndrome RGD PMID:23349861 RGD:13800789 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mc4r melanocortin 4 receptor ISO CTD Direct Evidence: marker/mechanism
DNA:nonsense mutation:cds:p.K314X (rat)
mRNA, protein:decreased expression:liver (rat)		 CTD
RGD		 PMID:18454146 PMID:24400148 PMID:35945320 RGD:13825242, RGD:329951016 NCBI chr18:66,990,776...66,993,558
Ensembl chr18:66,990,775...66,993,577 		JBrowse link
G Metrnl meteorin, glial cell differentiation regulator-like ISO CTD Direct Evidence: therapeutic CTD PMID:30213948 NCBI chr11:121,593,253...121,608,215
Ensembl chr11:121,592,370...121,607,132 		JBrowse link
G Mettl14 methyltransferase 14, N6-adenosine-methyltransferase subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chr 3:123,161,944...123,179,639
Ensembl chr 3:123,161,946...123,179,757 		JBrowse link
G Mfn2 mitofusin 2 treatment ISO RGD PMID:24715199 RGD:13204838 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) ISO protein:increased expression:plasma RGD PMID:12552367 RGD:1641955 NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074 		JBrowse link
G Mir125a microRNA 125a IMP RGD PMID:31988048 RGD:21403676 NCBI chr17:18,051,074...18,051,141
Ensembl chr17:18,051,074...18,051,141 		JBrowse link
G Mir155 microRNA 155 ISO
IMP		 miRNA:increased expression:serum RGD PMID:29479888 PMID:27711113 RGD:24922220, RGD:25671464 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mir222 microRNA 222 ISO associated with polycystic ovary syndrome; RNA:increased expression:blood RGD PMID:33230470 RGD:151893462 NCBI chr  X:19,013,132...19,013,210
Ensembl chr  X:19,013,132...19,013,210 		JBrowse link
G Mlxipl MLX interacting protein-like treatment ISO RGD PMID:26394137 RGD:329955565 NCBI chr 5:135,118,744...135,168,622
Ensembl chr 5:135,118,744...135,167,236 		JBrowse link
G Mlycd malonyl-CoA decarboxylase treatment ISO RGD PMID:26394137 RGD:329955565 NCBI chr 8:120,121,591...120,148,577
Ensembl chr 8:120,121,617...120,137,841 		JBrowse link
G Mrc1 mannose receptor, C type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29035695 NCBI chr 2:14,234,225...14,336,834
Ensembl chr 2:14,234,203...14,336,868 		JBrowse link
G n-TUtca2 nuclear encoded tRNA selenocysteine 2 (anticodon TCA) EXP CTD Direct Evidence: marker/mechanism CTD PMID:28228267 NCBI chr 7:19,035,169...19,035,255 JBrowse link
G Nampt nicotinamide phosphoribosyltransferase ISO associated with Polycystic Ovary Syndrome;protein:increased expression:serum RGD PMID:17582143 RGD:1642341 NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348 		JBrowse link
G Neil1 nei endonuclease VIII-like 1 (E. coli) ISO CTD Direct Evidence: marker/mechanism CTD PMID:21285402 NCBI chr 9:57,050,072...57,055,973
Ensembl chr 9:57,050,084...57,055,589 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 ISO associated with obesity; protein:decreased expression:hepatocyte:
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:33933676 PMID:32102936 RGD:21201281 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO
IMP		 mRNA, protein:increased expression:retroperitoneum, adipose tissue (rat) RGD PMID:22023455 PMID:21846719 RGD:5509041, RGD:5509075 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell treatment ISO protein:decreased expression:serum
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:11457755 PMID:12716763 PMID:12947532 PMID:19008412 PMID:18298918 More... RGD:2292098, RGD:13450950 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nppb natriuretic peptide type B ISO associated with Obesity and Hypertension;protein:decreased expression:serum RGD PMID:17392814 RGD:1642192 NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 susceptibility IAGP RGD PMID:16557297 RGD:1625076 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17785466 NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17785466 NCBI chr 4:48,045,098...48,086,446
Ensembl chr 4:48,045,153...48,086,447 		JBrowse link
G Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit ISO CTD Direct Evidence: therapeutic CTD PMID:33812996 NCBI chr10:52,293,643...52,316,288
Ensembl chr10:52,293,643...52,316,279 		JBrowse link
G Parl presenilin associated, rhomboid-like ISO mRNA:decreased expression:gastrocnemius (rat) RGD PMID:19859837 RGD:12880442 NCBI chr16:20,098,570...20,121,090
Ensembl chr16:20,098,568...20,121,137 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 IEP
ISO		 associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression:pancreatic islet (mouse)
protein:increased expression:pancreatic duct (rat)		 RGD PMID:18288891 PMID:16046294 RGD:2311222, RGD:2311223 NCBI chr 5:147,206,907...147,212,658
Ensembl chr 5:147,206,769...147,212,658 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IAGP
ISO		 associated with Pre-Eclampsia;protein:increased tyrosine phosphorylation:placenta
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:14714311 PMID:17283057 PMID:10426374 PMID:16332940 RGD:1625211, RGD:1625262, RGD:1625212 NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725 		JBrowse link
G Pklr pyruvate kinase liver and red blood cell treatment IEP
ISO		 mRNA, protein:decreased expression:liver RGD PMID:12958186 PMID:26394137 RGD:1625583, RGD:329955565 NCBI chr 3:89,043,429...89,054,122
Ensembl chr 3:89,043,449...89,054,091 		JBrowse link
G Pla2g1b phospholipase A2, group IB, pancreas susceptibility IMP RGD PMID:12376327 RGD:1302550 NCBI chr 5:115,604,201...115,612,781
Ensembl chr 5:115,604,321...115,612,781 		JBrowse link
G Plac8 placenta-specific 8 ISO associated with obesity RGD PMID:26296322 RGD:10755343 NCBI chr 5:100,699,455...100,720,119
Ensembl chr 5:100,701,591...100,720,111 		JBrowse link
G Plekhs1 pleckstrin homology domain containing, family S member 1 ISO associated with obesity; RGD PMID:27523322 RGD:11532750 NCBI chr19:56,445,705...56,475,161
Ensembl chr19:56,450,072...56,475,184 		JBrowse link
G Plin2 perilipin 2 IDA associated with Obesity RGD PMID:17484887 RGD:1625752 NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297 		JBrowse link
G Pltp phospholipid transfer protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:12754275 NCBI chr 2:164,681,441...164,699,564
Ensembl chr 2:164,681,438...164,699,631 		JBrowse link
G Pmch pro-melanin-concentrating hormone ISO RGD PMID:16002548 RGD:1642484 NCBI chr10:87,926,934...87,928,236
Ensembl chr10:87,926,934...87,928,237 		JBrowse link
G Pon1 paraoxonase 1 ISO DNA:SNP:CDS:p.L55M (human), LL genotype (P < 0.001) RGD PMID:11788650 RGD:1642617 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha IDA
ISO		 CTD Direct Evidence: therapeutic CTD
RGD		 PMID:16168052 PMID:21324916 PMID:19322024 RGD:5683642 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Ppard peroxisome proliferator activator receptor delta IDA associated with Diabetes Mellitus, Non-Insulin-Dependent
associated with Obesity		 RGD PMID:19818749 PMID:14676330 RGD:2313780, RGD:2324897 NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO DNA:nonsense mutation
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:16168052 PMID:21354099 PMID:21484566 PMID:12118251 RGD:1601446 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha treatment ISO DNA:missense mutation:cds:p.G482S rs8192678 (human)
mRNA:decreased expression:liver (rat)		 RGD PMID:23449621 PMID:22658649 PMID:26394137 RGD:7241821, RGD:7242170, RGD:329955565 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta treatment ISO RGD PMID:16896940 PMID:26394137 RGD:1642499, RGD:329955565 NCBI chr18:61,424,516...61,533,846
Ensembl chr18:61,431,207...61,533,502 		JBrowse link
G Ppp1r3a protein phosphatase 1, regulatory subunit 3A ISO DNA:polymorphism:exon:p.D905Y (human)
DNA:nonsense mutation
ClinVar Annotator: match by term: Insulin resistance, susceptibility to		 ClinVar
RGD		 PMID:7581368 PMID:25741868 PMID:7581368 PMID:12118251 RGD:1601468, RGD:1601446 NCBI chr 6:14,713,821...14,755,273
Ensembl chr 6:14,713,976...14,755,273 		JBrowse link
G Prdx3 peroxiredoxin 3 ISO associated with obesity; RGD PMID:27523322 RGD:11532750 NCBI chr19:60,852,504...60,862,976
Ensembl chr19:60,852,489...60,862,994 		JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit ISO associated with Obesity
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:19934007 PMID:22231922 RGD:6484545 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380 		JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit susceptibility ISO DNA:SNPs
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:19934007 PMID:16567511 RGD:1625266 NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087 		JBrowse link
G Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:29367455 NCBI chr11:109,539,849...109,560,489
Ensembl chr11:109,540,231...109,560,482 		JBrowse link
G Prkcb protein kinase C, beta ISO RGD PMID:12665248 RGD:1625515 NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625 		JBrowse link
G Prkcd protein kinase C, delta ISO
IMP		 protein:altered localization:nucleus
associated with Obesity;protein:increased activity:adipocyte		 RGD PMID:12217885 PMID:15507533 RGD:729667, RGD:1642527 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167 		JBrowse link
G Prkcq protein kinase C, theta ISO associated with Obesity;protein:decreased expression:skeletal muscle
protein:altered localization:skeletal muscle		 RGD PMID:10923637 PMID:9000691 RGD:1625603, RGD:1625604 NCBI chr 2:11,176,922...11,306,033
Ensembl chr 2:11,176,919...11,306,033 		JBrowse link
G Prkcz protein kinase C, zeta ISO RGD PMID:12882908 RGD:1642650 NCBI chr 4:155,344,579...155,445,856
Ensembl chr 4:155,344,586...155,445,818 		JBrowse link
G Prkd1 protein kinase D1 susceptibility ISO human gene in a mouse model RGD PMID:25173922 RGD:307436943 NCBI chr12:50,388,009...50,696,075
Ensembl chr12:50,388,014...50,695,881 		JBrowse link
G Prl prolactin ISO associated with Hyperprolactinemia RGD PMID:3888755 RGD:1642560 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Prmt7 protein arginine N-methyltransferase 7 ISO ClinVar Annotator: match by term: Insulin resistance ClinVar PMID:25741868 PMID:26437029 PMID:27718516 PMID:28492532 PMID:28902392 NCBI chr 8:106,937,686...106,978,326
Ensembl chr 8:106,937,568...106,979,426 		JBrowse link
G Pten phosphatase and tensin homolog ISO protein:increased expression, decreased acetylation:liver
CTD Direct Evidence: marker/mechanism
protein:increased activity:liver (human)		 CTD
RGD		 PMID:18303120 PMID:18385463 PMID:24367090 RGD:2292521, RGD:127285595 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Ptgds prostaglandin D2 synthase (brain) susceptibility IAGP RGD PMID:15970590 RGD:1642581 NCBI chr 2:25,356,723...25,360,080
Ensembl chr 2:25,356,721...25,360,058 		JBrowse link
G Ptgis prostaglandin I2 (prostacyclin) synthase ISO protein:decreased activity:aorta (rat) RGD PMID:16528409 RGD:401960098 NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524 		JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta IAGP associated with Obesity RGD PMID:16039993 RGD:1642605 NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO DNA:insertion:3'utr:1484insG
ClinVar Annotator: match by term: Insulin resistance, susceptibility to
CTD Direct Evidence: marker/mechanism
associated with congestive heart failure;protein:increased expression, increased activity:heart (rat)		 ClinVar
CTD
RGD		 PMID:10744717 PMID:11833006 PMID:11833006 PMID:29929988 RGD:1625240, RGD:401965403 NCBI chr 2:167,772,670...167,821,305
Ensembl chr 2:167,773,977...167,821,305 		JBrowse link
G Ptprf protein tyrosine phosphatase receptor type F ISO mouse model overexpressing human transgene RGD PMID:11309481 PMID:9218523 RGD:1642735, RGD:1642733 NCBI chr 4:118,065,410...118,148,602
Ensembl chr 4:118,065,410...118,148,602 		JBrowse link
G Pyy peptide YY ISO protein:decreased expression RGD PMID:17045646 RGD:1625281 NCBI chr11:101,997,502...101,998,658
Ensembl chr11:101,997,502...101,998,658 		JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO mRNA:decreased expression:adipose tissue RGD PMID:23315497 RGD:8547988 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
G Rbp4 retinol binding protein 4, plasma disease_progression
ameliorates		 ISO protein:decreased expression:blood serum (human) RGD PMID:29747616 PMID:21365528 RGD:329849113, RGD:329853304 NCBI chr19:38,105,068...38,113,769
Ensembl chr19:38,105,077...38,113,729 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) IEP
ISO		 protein:altered localization:soleus RGD PMID:18198644 PMID:18073321 RGD:2298857, RGD:2298860 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Retn resistin ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16493877 PMID:18789551 RGD:2313499 NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110 		JBrowse link
G Rrad Ras-related associated with diabetes ISO RGD PMID:16537411 RGD:2311703 NCBI chr 8:105,354,702...105,357,921
Ensembl chr 8:105,354,702...105,357,959 		JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 treatment EXP
ISO		 CTD Direct Evidence: therapeutic CTD
RGD		 PMID:21661758 PMID:26394137 RGD:329955565 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318 		JBrowse link
G Selenop selenoprotein P ISO CTD Direct Evidence: marker/mechanism CTD PMID:14714311 NCBI chr15:3,300,249...3,309,992
Ensembl chr15:3,298,029...3,309,990 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 treatment ISO mRNA:increased expression:white adipose tissue (rat) RGD PMID:19776253 PMID:26188590 RGD:8547949, RGD:11073726 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 treatment ISO associated with Hypertension
human protein in a rat model		 RGD PMID:19073347 PMID:24288442 PMID:22714715 RGD:2312339, RGD:8642993, RGD:8655563 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527 		JBrowse link
G Shc1 src homology 2 domain-containing transforming protein C1 ISO mRNA:increased expression:adipose tissue RGD PMID:17986714 RGD:1643171 NCBI chr 3:89,325,858...89,337,336
Ensembl chr 3:89,325,750...89,337,334 		JBrowse link
G Sirt1 sirtuin 1 treatment ISO associated with Obesity
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:20068143 PMID:21321189 PMID:24442997 PMID:25849131 PMID:26026874 More... RGD:9585759 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Sirt4 sirtuin 4 ISO RGD PMID:20651844 RGD:9586052 NCBI chr 5:115,616,065...115,628,322
Ensembl chr 5:115,616,069...115,622,784 		JBrowse link
G Sis sucrase isomaltase ISO associated with Diabetes Mellitus, Type 2;mRNA:increased expression:small intestine RGD PMID:9878708 RGD:1625544 NCBI chr 3:72,795,890...72,875,196
Ensembl chr 3:72,795,890...72,875,196 		JBrowse link
G Slc27a1 solute carrier family 27 (fatty acid transporter), member 1 ISO protein::heart:basal level increased but unresponsive to insulin on a high cholesterol, high fructose diet RGD PMID:17400720 RGD:1642795 NCBI chr 8:72,021,372...72,039,951
Ensembl chr 8:72,021,526...72,039,946 		JBrowse link
G Slc27a4 solute carrier family 27 (fatty acid transporter), member 4 ISO mRNA:increased expression:subcutaneous adipose tissue RGD PMID:15168018 RGD:1625638 NCBI chr 2:29,692,646...29,707,534
Ensembl chr 2:29,692,646...29,707,534 		JBrowse link
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 ISO RGD PMID:11436180 RGD:1642802 NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 ISO associated with Heart Failure, Congestive;protein:decreased expression:skeletal muscle
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:11947963 PMID:18778861 RGD:2313624 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 IMP associated with Diabetes Mellitus RGD PMID:15240880 RGD:1625677 NCBI chr16:10,601,672...10,603,400
Ensembl chr16:10,600,104...10,603,400 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 susceptibility IMP
IAGP		 associated with Diabetes Mellitus
associated with Obesity		 RGD PMID:15240880 PMID:17295835 RGD:1625677, RGD:2313789 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO CTD Direct Evidence: therapeutic CTD PMID:22829583 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sod3 superoxide dismutase 3, extracellular ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma RGD PMID:15171689 RGD:1625698 NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760 		JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 susceptibility IAGP RGD PMID:17351624 RGD:1642731 NCBI chr19:40,280,484...40,502,399
Ensembl chr19:40,283,197...40,502,223 		JBrowse link
G Sox6 SRY (sex determining region Y)-box 6 IDA RGD PMID:16148004 RGD:1581307 NCBI chr 7:115,070,107...115,639,186
Ensembl chr 7:115,070,107...115,638,031 		JBrowse link
G Sqstm1 sequestosome 1 ISO CTD Direct Evidence: therapeutic CTD PMID:33933676 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 susceptibility
treatment		 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP
associated with Fatty Liver;mRNA:increased expression:liver
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:22658938 PMID:18692268 PMID:17241878 PMID:26394137 RGD:2308809, RGD:2308807, RGD:329955565 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Srebf2 sterol regulatory element binding factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20699619 NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580 		JBrowse link
G Stk11 serine/threonine kinase 11 ISO associated with obesity;protein:decreased expression:gastrocnemius RGD PMID:16352671 RGD:1601389 NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516 		JBrowse link
G Sts steroid sulfatase ISO CTD Direct Evidence: therapeutic CTD PMID:24497646 NCBI chr  X:168,856,332...169,015,037
Ensembl chr  X:168,909,030...169,014,924 		JBrowse link
G Syn1 synapsin I ISO RGD PMID:29566703 RGD:13542091 NCBI chr  X:20,726,750...20,787,157
Ensembl chr  X:20,726,750...20,787,243 		JBrowse link
G Tbc1d4 TBC1 domain family, member 4 ISO ClinVar Annotator: match by term: Insulin resistance ClinVar NCBI chr14:101,679,800...101,846,717
Ensembl chr14:101,679,796...101,846,627 		JBrowse link
G Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box ISO DNA:SNP (human) RGD PMID:19509102 RGD:2312433 NCBI chr19:55,730,227...55,922,091
Ensembl chr19:55,730,252...55,922,086 		JBrowse link
G Tfap2b transcription factor AP-2 beta ISO RGD PMID:16373417 RGD:1601544 NCBI chr 1:19,279,132...19,309,071
Ensembl chr 1:19,279,138...19,308,800 		JBrowse link
G Thbd thrombomodulin ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:11453033 RGD:2312460 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108 		JBrowse link
G Tlr4 toll-like receptor 4 severity IAGP
ISO		 associated with Obesity
protein:increased expression:skeletal muscle		 RGD PMID:19675137 PMID:18633101 PMID:17426960 RGD:2312483, RGD:2312489, RGD:1620681 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor treatment ISO associated with Obesity
CTD Direct Evidence: marker/mechanism
associated with obesity		 CTD
RGD		 PMID:16493877 PMID:20943792 PMID:14764603 PMID:25016878 PMID:9832430 RGD:1580214, RGD:10450578, RGD:14995428 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) ISO associated with obesity;protein:increased expression:serum RGD PMID:15936463 RGD:1620889 NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased expression RGD PMID:11882518 RGD:1624180 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Trf transferrin ISO protein:increased expression:plasma RGD PMID:17350134 RGD:1601515 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643 		JBrowse link
G Trib3 tribbles pseudokinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20461355 NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952 		JBrowse link
G Tsc1 TSC complex subunit 1 IAGP RGD PMID:15380067 RGD:1624197 NCBI chr 2:28,531,005...28,581,183
Ensembl chr 2:28,531,240...28,581,179 		JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP:5' utr:-112A>C (rs10011540) (human) RGD PMID:16338218 RGD:1624979 NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) ISO DNA:polymorphism, insertion:promoter:-866G>A (rs659366)(human) RGD PMID:17870627 RGD:2313512 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227 		JBrowse link
G Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) ISO DNA:polymorphism:promoter:-55C>T (human) RGD PMID:17870627 PMID:17571165 RGD:2313512, RGD:2313515 NCBI chr 7:100,122,198...100,135,639
Ensembl chr 7:100,122,197...100,135,639 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO RGD PMID:11882338 RGD:1580351 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor IMP RGD PMID:25801026 RGD:14402022 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511 		JBrowse link
G Vwf Von Willebrand factor ISO protein:increased expression:plasma RGD PMID:16631442 RGD:1625711 NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642 		JBrowse link
G Xbp1 X-box binding protein 1 treatment IMP
ISO		 CTD Direct Evidence: therapeutic CTD
RGD		 PMID:27325692 PMID:15486293 PMID:26394137 RGD:2326004, RGD:329955565 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893 		JBrowse link
G Zc3h10 zinc finger CCCH type containing 10 ISO CTD Direct Evidence: therapeutic CTD PMID:31775033 NCBI chr10:128,379,429...128,383,877
Ensembl chr10:128,377,832...128,383,643 		JBrowse link
abdominal obesity-metabolic syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctf1 cardiotrophin 1 IAGP MouseDO NCBI chr 7:127,311,872...127,317,360
Ensembl chr 7:127,311,908...127,317,364 		JBrowse link
G Gucy2c guanylate cyclase 2c IAGP MouseDO NCBI chr 6:136,674,282...136,758,740
Ensembl chr 6:136,674,282...136,758,763 		JBrowse link
G Lep leptin IAGP MouseDO NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Neil1 nei endonuclease VIII-like 1 (E. coli) IAGP MouseDO NCBI chr 9:57,050,072...57,055,973
Ensembl chr 9:57,050,084...57,055,589 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:15309680 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma IAGP MouseDO NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha ISO mRNA:increased expression:gastrocnemius muscle (rat) RGD PMID:23320128 RGD:7241841 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Prkci protein kinase C, iota IAGP MouseDO NCBI chr 3:31,049,893...31,106,889
Ensembl chr 3:31,049,896...31,107,108 		JBrowse link
G Sirt3 sirtuin 3 IAGP MouseDO NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222 		JBrowse link
G Slc2a9 solute carrier family 2 (facilitated glucose transporter), member 9 IAGP MouseDO NCBI chr 5:38,506,616...38,660,488
Ensembl chr 5:38,506,616...38,660,486 		JBrowse link
abdominal obesity-metabolic syndrome 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 ISO protein:increased oxidation:cardiac muscle cell RGD PMID:23997093 RGD:13782087 NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288 		JBrowse link
G Bax BCL2-associated X protein treatment ISO RGD PMID:27131981 RGD:13792503 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 treatment ISO RGD PMID:27131981 RGD:13792503 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Fadd Fas associated via death domain treatment ISO RGD PMID:27131981 RGD:13792503 NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200 		JBrowse link
G Fas Fas cell surface death receptor ISO RGD PMID:30172001 RGD:13792561 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Lep leptin IAGP OMIM:605552 MouseDO NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lpl lipoprotein lipase treatment ISO RGD PMID:26996629 RGD:13794382 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100 		JBrowse link
G Mttp microsomal triglyceride transfer protein ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 1 ClinVar PMID:8533758 PMID:9671739 PMID:16199547 PMID:16721486 PMID:21394827 More... NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729 		JBrowse link
G Tlr2 toll-like receptor 2 susceptibility IMP RGD PMID:19841034 RGD:15090861 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Trp53inp1 transformation related protein 53 inducible nuclear protein 1 IAGP OMIM:605552 MouseDO NCBI chr 4:11,156,441...11,174,379
Ensembl chr 4:11,156,431...11,174,379 		JBrowse link
abdominal obesity-metabolic syndrome 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahdc1 AT hook, DNA binding motif, containing 1 ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 3 ClinVar PMID:25741868 PMID:29696776 PMID:33644933 NCBI chr 4:132,738,797...132,805,421
Ensembl chr 4:132,738,571...132,805,421 		JBrowse link
G Dyrk1b dual-specificity tyrosine phosphorylation regulated kinase 1b ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 3 | ClinVar Annotator: match by term: CENTRAL OBESITY, TYPE 2 DIABETES, HYPERTENSION, AND EARLY-ONSET CORONARY ARTERY DISEASE | ClinVar Annotator: match by term: DYRK1B-related condition OMIM
ClinVar		 PMID:9536098 PMID:17576681 PMID:24827035 PMID:25741868 PMID:28492532 More... NCBI chr 7:27,878,880...27,896,896
Ensembl chr 7:27,878,894...27,886,719 		JBrowse link
abdominal obesity-metabolic syndrome 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cela2a chymotrypsin-like elastase family, member 2A ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 4 OMIM
ClinVar		 PMID:25741868 PMID:31358993 NCBI chr 4:141,542,265...141,553,316
Ensembl chr 4:141,542,273...141,553,471 		JBrowse link
Insulin-Resistant Diabetes Mellitus, with Acanthosis Nigricans term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor ISO ClinVar Annotator: match by term: DIABETES MELLITUS, INSULIN-RESISTANT, WITH ACANTHOSIS NIGRICANS, TYPE A | ClinVar Annotator: match by term: IRAN, TYPE A
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD		 PMID:1644241 PMID:1963473 PMID:1971035 PMID:2002058 PMID:2040394 More... NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617 		JBrowse link
G Lmna lamin A ISO ClinVar Annotator: match by term: IRAN, TYPE A ClinVar PMID:15919811 PMID:16478798 PMID:20848652 PMID:23785128 PMID:24033266 More... NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263 		JBrowse link
Metabolic Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 susceptibility ISO DNA:SNP:exon:p.R230C (rs9282541) (human) RGD PMID:17287470 RGD:1601092 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha ameliorates IEP
ISO		 mRNA:increased expression:liver (mouse) RGD PMID:29684438 PMID:27821167 RGD:329333017, RGD:401799622 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477 		JBrowse link
G Acacb acetyl-Coenzyme A carboxylase beta IEP mRNA:increased expression:liver (mouse) RGD PMID:29684438 RGD:329333017 NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822 		JBrowse link
G Acadvl acyl-Coenzyme A dehydrogenase, very long chain treatment ISO RGD PMID:25191539 RGD:10047118 NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237 		JBrowse link
G Acat2 acetyl-Coenzyme A acetyltransferase 2 susceptibility ISO DNA:polymorphism RGD PMID:14557872 RGD:1581921 NCBI chr17:13,161,929...13,179,612
Ensembl chr17:13,161,777...13,179,634 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO
IMP		 associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP: :276G>T (human)
CTD Direct Evidence: marker/mechanism
associated with vascular diseases; protein:decreased expression:plasma
protein:decreased expression:serum		 CTD
RGD		 PMID:16793964 PMID:17618945 PMID:18162013 PMID:20833989 PMID:19690575 More... RGD:2313234, RGD:5686800, RGD:5686428, RGD:5686407 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adrb2 adrenergic receptor, beta 2 susceptibility ISO DNA:polymorphisms: :p.R16G, p.Q27E RGD
GAD		 PMID:14557466 PMID:15118671 RGD:1601127, RGD:1331525 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030 		JBrowse link
G Agt angiotensinogen ISO mRNA, protein:increased expression:adipose tissue RGD PMID:17260464 RGD:1601134 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a susceptibility ISO DNA:snp:3' utr:c.5186A>C RGD PMID:17211857 RGD:1601146 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Akp3 alkaline phosphatase 3, intestine, not Mn requiring IMP RGD PMID:23569246 RGD:14349049 NCBI chr 1:87,052,676...87,056,450
Ensembl chr 1:87,052,695...87,055,634 		JBrowse link
G Aldoa aldolase A, fructose-bisphosphate ISO mRNA:increased expression:aorta RGD PMID:21890532 RGD:13673877 NCBI chr 7:126,394,406...126,399,537
Ensembl chr 7:126,394,406...126,399,923 		JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney susceptibility ISO protein:increased expression:serum RGD PMID:16249437 RGD:1601174 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695 		JBrowse link
G Apoa1 apolipoprotein A-I ISO protein:decreased expression:serum (human)
DNA: polymorphism: :G2, G3 and G5		 RGD PMID:17217166 PMID:21410987 RGD:1601183, RGD:5508220 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Apoa2 apolipoprotein A-II ISO protein:decreased expression:serum RGD PMID:19817643 RGD:2313955 NCBI chr 1:171,049,133...171,053,948
Ensembl chr 1:171,052,623...171,053,948 		JBrowse link
G Apoa5 apolipoprotein A-V susceptibility ISO DNA:polymorphism: :p.S19W (human) RGD PMID:18789138 RGD:2313315 NCBI chr 9:46,179,906...46,183,219
Ensembl chr 9:46,179,931...46,183,217 		JBrowse link
G Apob apolipoprotein B ISO protein:increased expression:plasma RGD PMID:16828905 RGD:1601198 NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835 		JBrowse link
G Apoc3 apolipoprotein C-III susceptibility ISO protein:increased expression:serum (human)
DNA:polymorphism:promoter:-482C>T, -455T>C		 RGD PMID:16298371 PMID:17416293 RGD:2306766, RGD:1601223 NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934 		JBrowse link
G Apom apolipoprotein M ISO protein:decreased expression:plasma RGD PMID:19539616 RGD:2314236 NCBI chr17:35,347,973...35,350,777
Ensembl chr17:35,347,973...35,351,026 		JBrowse link
G Atm ataxia telangiectasia mutated IDA RGD PMID:17084711 RGD:1601248 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040 		JBrowse link
G Atp12a ATPase, H+/K+ transporting, nongastric, alpha polypeptide ISO RGD PMID:23320804 RGD:13838660 NCBI chr14:56,602,525...56,626,008
Ensembl chr14:56,602,525...56,626,007 		JBrowse link
G Bche butyrylcholinesterase ISO protein:increased expression:serum RGD PMID:15907830 RGD:1601317 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748 		JBrowse link
G Bdnf brain derived neurotrophic factor ISO RGD PMID:11935372 RGD:1580935 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Bglap bone gamma carboxyglutamate protein ISO protein:decreased expression:serum RGD PMID:21760737 RGD:6483594 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771 		JBrowse link
G C3 complement component 3 ISO RGD PMID:16488421 RGD:2314030 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Capn10 calpain 10 ISO DNA:polymorphism RGD PMID:16546286 RGD:1625050 NCBI chr 1:92,862,130...92,875,670
Ensembl chr 1:92,862,098...92,875,663 		JBrowse link
G Cck cholecystokinin ISO RGD PMID:17443025 RGD:1625798 NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16188961 PMID:18486454 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased secretion:plasma (rat) RGD PMID:19905967 RGD:4889977 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Cd163 CD163 antigen susceptibility ISO protein:increased expression:blood serum (human) RGD PMID:31027316 RGD:127345132 NCBI chr 6:124,281,596...124,307,488
Ensembl chr 6:124,281,615...124,307,486 		JBrowse link
G Cd36 CD36 molecule ISO DNA:SNPs: :multiple (human) RGD PMID:9916795 PMID:18305138 RGD:619666, RGD:2307208 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:serum RGD PMID:16423632 PMID:20006362 RGD:2314214, RGD:5490591 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Cela2a chymotrypsin-like elastase family, member 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:31358993 NCBI chr 4:141,542,265...141,553,316
Ensembl chr 4:141,542,273...141,553,471 		JBrowse link
G Chek2 checkpoint kinase 2 ISO mRNA:increased expression:heart left ventricle (rat) RGD PMID:25129990 RGD:10400905 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011 		JBrowse link
G Ciita class II transactivator ISO DNA:polymorphism:promoter:-168A>G (human) RGD PMID:17183695 RGD:5491201 NCBI chr16:10,297,877...10,348,928
Ensembl chr16:10,297,923...10,346,282 		JBrowse link
G Crp C-reactive protein, pentraxin-related ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16644639 PMID:21357282 RGD:6482318 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Cst3 cystatin C ISO protein:increased expression:serum (human) RGD PMID:19887833 RGD:2314295 NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612 		JBrowse link
G Cyba cytochrome b-245, alpha polypeptide ISO RGD PMID:16741160 RGD:2317864 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 susceptibility ISO DNA:polymorphism:promoter:-344C>T (human) RGD PMID:17261471 RGD:2307294 NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,467...74,728,167 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Ddr1 discoidin domain receptor family, member 1 IMP RGD PMID:32360427 RGD:151347874 NCBI chr17:35,992,459...36,015,633
Ensembl chr17:35,992,459...36,015,513 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 treatment IMP RGD PMID:21990351 RGD:10401057 NCBI chr15:76,386,215...76,396,167
Ensembl chr15:76,386,215...76,396,153 		JBrowse link
G Dio2 deiodinase, iodothyronine, type II ISO DNA:polymorphism: :p.T92A (human) RGD PMID:18198294 RGD:2313696 NCBI chr12:90,691,326...90,705,812
Ensembl chr12:90,691,326...90,705,812 		JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic ISO RGD PMID:22007192 RGD:5688391 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949 		JBrowse link
G F3 coagulation factor III ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:12417540 RGD:2313865 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G Fabp2 fatty acid binding protein 2, intestinal ISO RGD PMID:16919542 RGD:1626401 NCBI chr 3:122,688,721...122,693,155
Ensembl chr 3:122,688,721...122,693,155 		JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte ISO protein:increased expression:serum RGD PMID:16919044 RGD:1625406 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636 		JBrowse link
G Fadd Fas associated via death domain ISO protein:increased expression:heart left ventricle RGD PMID:23657904 RGD:11344884 NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200 		JBrowse link
G Fas Fas cell surface death receptor ISO mRNA:increased expression:liver (rat) RGD PMID:11934685 RGD:628329 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasn fatty acid synthase ameliorates IEP
ISO		 mRNA:increased expression:liver (mouse) RGD PMID:29684438 PMID:31353547 PMID:27821167 RGD:329333017, RGD:401850595, RGD:401799622 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Fgf15 fibroblast growth factor 15 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28673684 NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690 		JBrowse link
G Fgf21 fibroblast growth factor 21 treatment IDA RGD PMID:25306889 RGD:10401890 NCBI chr 7:45,263,314...45,264,914
Ensembl chr 7:45,263,310...45,264,914 		JBrowse link
G Fto FTO alpha-ketoglutarate dependent dioxygenase ISO DNA:SNPs: :rs1421085, rs1558902, rs8050136, rs9939609 (human)
DNA:SNP: :rs9939973 (human)		 RGD PMID:21796137 PMID:32061761 RGD:329853776, RGD:329901771 NCBI chr 8:92,039,995...92,395,061
Ensembl chr 8:92,040,153...92,395,067 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 ameliorates ISO RGD PMID:27821167 RGD:401799622 NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked treatment ISO RGD PMID:19374165 PMID:24868532 RGD:2307350, RGD:10449117 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gcg glucagon ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr 2:62,304,874...62,313,997
Ensembl chr 2:62,304,874...62,313,994 		JBrowse link
G Gch1 GTP cyclohydrolase 1 treatment ISO RGD PMID:34200262 RGD:329970293 NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870 		JBrowse link
G Gck glucokinase ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081 		JBrowse link
G Gckr glucokinase regulatory protein ISO RGD PMID:19861489 RGD:7242423 NCBI chr 5:31,454,594...31,484,646
Ensembl chr 5:31,454,787...31,484,658 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 susceptibility ISO RGD PMID:17095717 PMID:24847614 RGD:1601300, RGD:14747015 NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034 		JBrowse link
G Ghrl ghrelin ISO associated with Kidney Diseases;protein:decreased expression:serum
ClinVar Annotator: match by term: Metabolic syndrome, susceptibility to
In peritoneal dialysis patients
DNA:polymorphisms		 ClinVar
RGD		 PMID:11502844 PMID:12050239 PMID:12161552 PMID:16204371 PMID:25741868 More... RGD:2313748, RGD:7242555, RGD:1625021 NCBI chr 6:113,693,080...113,696,872
Ensembl chr 6:113,693,080...113,696,841 		JBrowse link
G Gpr17 G protein-coupled receptor 17 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34144038 NCBI chr18:32,076,052...32,082,925
Ensembl chr18:32,076,050...32,082,689 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO protein:increased expression:serum RGD PMID:24819036 RGD:401827122 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Gsn gelsolin severity IMP RGD PMID:29684438 RGD:329333017 NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 ISO RGD PMID:29452132 RGD:14700976 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Hdac3 histone deacetylase 3 ISO RGD PMID:21763752 RGD:9590183 NCBI chr18:38,070,024...38,088,073
Ensembl chr18:38,068,897...38,088,069 		JBrowse link
G Hgf hepatocyte growth factor ISO RGD PMID:15713721 RGD:1642702 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150 		JBrowse link
G Hmga1 high mobility group AT-hook 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23512162 NCBI chr17:27,774,798...27,782,649
Ensembl chr17:27,775,471...27,782,648 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase ameliorates ISO
IEP		 RGD PMID:19461650 PMID:31353547 PMID:27821167 RGD:5508692, RGD:401850595, RGD:401799622 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO RGD PMID:22193921 RGD:10763276 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hnf4a hepatic nuclear factor 4, alpha ISO RGD PMID:16804065 RGD:1601642 NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830 		JBrowse link
G Hp haptoglobin treatment ISO protein:increased expression RGD PMID:17007284 PMID:20508159 RGD:1626341, RGD:11041859 NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 disease_progression
susceptibility		 ISO mRNA:increased expression:ascending aorta,epicardial fat (human)
DNA:SNP: (rs12086634)T>G (human)
DNA:SNPs:5'utr,enhancer: (rs846910,rs12086634) (human)
DNA:SNP:: (rs846910) (human)		 RGD PMID:14697232 PMID:23007990 PMID:23869418 PMID:21622477 PMID:28750217 RGD:1625074, RGD:329901930, RGD:329901929, RGD:329901919, RGD:329901909 NCBI chr 1:192,903,917...192,946,345
Ensembl chr 1:192,903,942...192,946,383 		JBrowse link
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C ISO CTD Direct Evidence: marker/mechanism CTD PMID:17632216 PMID:18515891 PMID:19142101 NCBI chr  X:145,745,509...145,980,273
Ensembl chr  X:145,745,509...145,980,273 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:serum RGD PMID:19394054 RGD:2313467 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial susceptibility IMP RGD PMID:31064654 RGD:14985252 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
G Igf2 insulin-like growth factor 2 ISO DNA:insertion RGD PMID:18418699 RGD:2311520 NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 ISO RGD PMID:16915540 RGD:1626481 NCBI chr 1:72,863,650...72,891,633
Ensembl chr 1:72,863,662...72,891,633 		JBrowse link
G Il18 interleukin 18 treatment ISO protein:increased expression:serum
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16644639 PMID:19717152 PMID:24456735 RGD:4889401, RGD:8655985 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16644639 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Il6ra interleukin 6 receptor, alpha susceptibility ISO DNA:polymorphism: :p.D358A RGD PMID:16817825 RGD:1625430 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 ISO DNA:SNPs: :rs2276047,snp8(human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15220217 PMID:15220217 RGD:1626127 NCBI chr 7:101,471,839...101,487,419
Ensembl chr 7:101,471,839...101,487,436 		JBrowse link
G Ins2 insulin II ISO CTD Direct Evidence: marker/mechanism CTD PMID:11274935 PMID:16259526 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Insr insulin receptor ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617 		JBrowse link
G Irs1 insulin receptor substrate 1 ameliorates ISO
IDA		 protein:decreased expression:skeletal muscle RGD PMID:10842668 PMID:31353547 RGD:6482864, RGD:401850595 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137 		JBrowse link
G Irs2 insulin receptor substrate 2 ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458 		JBrowse link
G Itgav integrin alpha V ISO RGD PMID:16784924 RGD:1627640 NCBI chr 2:83,554,796...83,637,261
Ensembl chr 2:83,554,741...83,637,260 		JBrowse link
G Kl klotho ISO
IMP		 mRNA:decreased expression:kidney: RGD PMID:11027545 PMID:11027545 RGD:10403056, RGD:10403056 NCBI chr 5:150,876,072...150,917,282
Ensembl chr 5:150,876,072...150,917,282 		JBrowse link
G Lbp lipopolysaccharide binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:23349936 NCBI chr 2:158,148,413...158,174,772
Ensembl chr 2:158,148,413...158,174,772 		JBrowse link
G Ldlr low density lipoprotein receptor ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Lep leptin ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma (rat)		 CTD
RGD		 PMID:16793964 PMID:18515891 PMID:19462476 PMID:25380250 RGD:2311125, RGD:10053625 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lepr leptin receptor ISO DNA:mutations:cds: : (rat)
DNA:mutations::cds: : (rat)		 RGD PMID:32710530 PMID:10901178 PMID:28746409 RGD:401960103, RGD:401965414, RGD:401965413 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Lipe lipase, hormone sensitive IEP mRNA:increased expression:liver (mouse) RGD PMID:29684438 RGD:329333017 NCBI chr 7:25,078,952...25,097,911
Ensembl chr 7:25,078,952...25,098,135 		JBrowse link
G Lipg lipase, endothelial ISO RGD PMID:16354105 RGD:1580865 NCBI chr18:75,072,393...75,095,380
Ensembl chr18:75,072,393...75,094,334 		JBrowse link
G Lmna lamin A ISO DNA:SNP: :c.138747C>T (human) RGD PMID:15205219 RGD:2306121 NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263 		JBrowse link
G Lrp6 low density lipoprotein receptor-related protein 6 ISO DNA:missense mutation:cds RGD PMID:17332414 RGD:2298725 NCBI chr 6:134,423,439...134,543,876
Ensembl chr 6:134,423,439...134,543,928 		JBrowse link
G Lrpap1 low density lipoprotein receptor-related protein associated protein 1 susceptibility ISO associated with Coronary Disease;DNA:SNP:exon RGD PMID:14557872 RGD:1581921 NCBI chr 5:35,248,834...35,263,043
Ensembl chr 5:35,248,845...35,263,110 		JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 ISO mRNA:decreased expression:blood, leukocyte (human) RGD PMID:26956845 RGD:155791561 NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809 		JBrowse link
G Mir122 microRNA 122 ISO miRNA:increased expression:serum RGD PMID:27899485 RGD:14401601 NCBI chr18:65,381,932...65,381,997
Ensembl chr18:65,381,932...65,381,997 		JBrowse link
G Mlxipl MLX interacting protein-like ameliorates ISO RGD PMID:27821167 RGD:401799622 NCBI chr 5:135,118,744...135,168,622
Ensembl chr 5:135,118,744...135,167,236 		JBrowse link
G Mtmr9 myotubularin related protein 9 ISO DNA:SNP: :rs2293855 (human) RGD PMID:21796137 RGD:329853776 NCBI chr14:63,757,100...63,781,402
Ensembl chr14:63,757,100...63,781,431 		JBrowse link
G Mttp microsomal triglyceride transfer protein ISO ClinVar Annotator: match by term: Metabolic syndrome X ClinVar PMID:8533758 PMID:9671739 PMID:16199547 PMID:16721486 PMID:21394827 More... NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase ISO DNA:repeats:intron
protein:increased expression:plasma		 RGD PMID:15922301 PMID:17556870 RGD:1642345, RGD:1642337 NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348 		JBrowse link
G Neil1 nei endonuclease VIII-like 1 (E. coli) ISO CTD Direct Evidence: marker/mechanism CTD PMID:16446448 PMID:17389588 NCBI chr 9:57,050,072...57,055,973
Ensembl chr 9:57,050,084...57,055,589 		JBrowse link
G Ngf nerve growth factor ISO RGD PMID:11935372 RGD:1580935 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nnmt nicotinamide N-methyltransferase ISO mRNA,protein:increased expression,increased activity:adipose tissue (rat) RGD PMID:25719492 RGD:401793724 NCBI chr 9:48,448,905...48,518,958
Ensembl chr 9:48,503,177...48,516,453 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell treatment ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Metabolic syndrome, susceptibility to		 CTD
ClinVar
RGD		 PMID:12947532 PMID:15269839 PMID:20876122 PMID:28361419 PMID:28967023 More... RGD:13461762, RGD:13450928 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nox1 NADPH oxidase 1 ISO protein:increased expression, increased activity:peripheral blood mononuclear cell (human) RGD PMID:16380495 RGD:1580973 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 ameliorates ISO RGD PMID:27821167 RGD:401799622 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20869355 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20869355 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic ameliorates ISO RGD PMID:27821167 RGD:401799622 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr 4:106,299,531...106,321,522
Ensembl chr 4:106,299,526...106,321,526 		JBrowse link
G Pde9a phosphodiesterase 9A treatment IMP RGD PMID:34618683 RGD:242170038 NCBI chr17:31,605,079...31,695,284
Ensembl chr17:31,605,184...31,695,284 		JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) ISO mRNA:decreased expression:liver RGD PMID:21172452 RGD:6482748 NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041 		JBrowse link
G Pla2g6 phospholipase A2, group VI ISO mRNA:decreased expression:liver RGD PMID:21172452 RGD:6482748 NCBI chr15:79,170,428...79,212,915
Ensembl chr15:79,170,428...79,212,590 		JBrowse link
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) ISO mRNA:increased expression:liver RGD PMID:21172452 RGD:6482748 NCBI chr17:43,879,009...43,923,093
Ensembl chr17:43,878,989...43,923,092 		JBrowse link
G Plat plasminogen activator, tissue ISO protein:increased expression:serum RGD PMID:18249307 RGD:2311664 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Pon1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:21573798 PMID:14602783 RGD:1642618 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ameliorates ISO
IEP		 mRNA:decreased expression:liver (rat) RGD PMID:11934685 PMID:31353547 RGD:628329, RGD:401850595 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma no_association
ameliorates		 ISO
IEP		 DNA:SNP: :p.P12A (human) RGD PMID:18959602 PMID:31353547 PMID:16186413 PMID:16183630 RGD:2301843, RGD:401850595, RGD:1580686, RGD:1580683 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha ISO mRNA:decreased expression:gastrocnemius muscle (rat) RGD PMID:20383225 RGD:10059661 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087 		JBrowse link
G Prl prolactin ISO RGD PMID:16303834 RGD:1642558 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO protein:increased expression:liver RGD PMID:17883899 RGD:1642586 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rbp4 retinol binding protein 4, plasma disease_progression ISO protein:increased expression:blood serum (human)
associated with obstructive sleep apnea;protein:increased expression:blood plasma (human)		 RGD PMID:19339013 PMID:19003725 RGD:329845591, RGD:329853307 NCBI chr19:38,105,068...38,113,769
Ensembl chr19:38,105,077...38,113,729 		JBrowse link
G Reg1 regenerating islet-derived 1 treatment ISO RGD PMID:21685239 RGD:10044029 NCBI chr 6:78,402,966...78,405,651
Ensembl chr 6:78,399,694...78,405,650 		JBrowse link
G Retn resistin ISO DNA:SNP:promoter:-420G>C (rs1862513) (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18328350 PMID:17598818 RGD:7207155 NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110 		JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 ameliorates ISO
IEP		 RGD PMID:27821167 PMID:31353547 RGD:401799622, RGD:401850595 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318 		JBrowse link
G Scg3 secretogranin III ISO DNA:SNP: :rs3764220 (human) RGD PMID:21796137 RGD:329853776 NCBI chr 9:75,550,648...75,591,733
Ensembl chr 9:75,550,471...75,591,338 		JBrowse link
G Selp selectin, platelet ISO RGD PMID:19061719 RGD:2312292 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595 		JBrowse link
G Serpina12 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 treatment ISO human protein in a mouse model RGD PMID:16030142 RGD:1547845 NCBI chr12:103,995,028...104,010,702
Ensembl chr12:103,995,028...104,010,702 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 treatment ISO RGD PMID:26084260 RGD:11073736 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Shbg sex hormone binding globulin ISO protein:decreased expression:serum
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16968811 PMID:17992261 PMID:17884445 RGD:2313785 NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731 		JBrowse link
G Sim1 single-minded family bHLH transcription factor 1 ISO ClinVar Annotator: match by term: SIM1-associated metabolic syndrome ClinVar NCBI chr10:50,770,794...50,865,252
Ensembl chr10:50,770,850...50,865,248 		JBrowse link
G Sirt1 sirtuin 1 treatment ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:hippocampus (rat)		 CTD
RGD		 PMID:20068143 PMID:21514307 PMID:25356430 RGD:9585758, RGD:10053569 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Slc27a1 solute carrier family 27 (fatty acid transporter), member 1 susceptibility IAGP DNA:gene knockout::Slc27a1-/- mice resistant to diet-induced obesity and metabolic syndrome RGD PMID:16611988 RGD:1642790 NCBI chr 8:72,021,372...72,039,951
Ensembl chr 8:72,021,526...72,039,946 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Soat2 sterol O-acyltransferase 2 susceptibility ISO DNA:SNPs RGD PMID:14557872 RGD:1581921 NCBI chr15:102,058,853...102,071,871
Ensembl chr15:102,058,961...102,071,904 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial treatment IEP RGD PMID:28875871 RGD:26923956 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 disease_progression
ameliorates		 IEP
ISO		 protein:increased expression:liver (mouse)
mRNA:increased expression:liver (rat)		 RGD PMID:29173234 PMID:31353547 PMID:11934685 RGD:401827867, RGD:401850595, RGD:628329 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO mRNA:increased expression:left heart ventricle RGD PMID:18692559 RGD:2306739 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Thbd thrombomodulin ISO associated with Diabetic Nephropathies;protein:increased expression:plasma RGD PMID:16567841 RGD:1601641 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108 		JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:24441717 RGD:10450604 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a ISO associated with obesity;protein:increased expression:plasma RGD PMID:17200772 RGD:1624178 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Trf transferrin susceptibility ISO protein:increased expression:serum RGD PMID:17416791 RGD:1601514 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643 		JBrowse link
G Trib3 tribbles pseudokinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18497449 NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) ISO mRNA:decreased expression:liver (rat) RGD PMID:11934685 RGD:628329 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227 		JBrowse link
G Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) treatment ISO RGD PMID:11934685 RGD:628329 NCBI chr 7:100,122,198...100,135,639
Ensembl chr 7:100,122,197...100,135,639 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO RGD PMID:18718174 RGD:2313109 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:plasma: RGD PMID:22206010 RGD:7483588 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vwf Von Willebrand factor ISO protein:increased expression:plasma RGD PMID:16764036 RGD:1625709 NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16269
    syndrome 10876
      hyperinsulinism 393
        Insulin Resistance 328
          HAIR-AN syndrome 0
          Insulin-Resistant Diabetes Mellitus, with Acanthosis Nigricans 2
          Metabolic Syndrome + 165
          Pseudoacromegaly with Severe Insulin Resistance 0
Path 2
Term Annotations click to browse term
  disease 16269
    Developmental Disease 14074
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 13131
        genetic disease 12822
          inherited metabolic disorder 6072
            carbohydrate metabolic disorder 2963
              glucose metabolism disease 1685
                hyperinsulinism 393
                  Insulin Resistance 328
                    HAIR-AN syndrome 0
                    Insulin-Resistant Diabetes Mellitus, with Acanthosis Nigricans 2
                    Metabolic Syndrome + 165
                    Pseudoacromegaly with Severe Insulin Resistance 0
paths to the root