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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chronic Bronchitis
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Accession:DOID:9007651 term browser browse the term
Definition:A subcategory of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. The disease is characterized by hypersecretion of mucus accompanied by a chronic (more than 3 months in 2 consecutive years) productive cough. Infectious agents are a major cause of chronic bronchitis.
Synonyms:primary_id: MESH:D029481
 xref: EFO:0006505


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Chronic Bronchitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL11 chemokine (C-C motif) ligand 11 ISO RGD PMID:11991282 RGD:4145442 NCBI chr12:40,779,906...40,782,862
Ensembl chr12:40,779,173...40,782,893 		JBrowse link
G CFTR CF transmembrane conductance regulator susceptibility ISO DNA:deletion: :F508del(human)
associated with pulmonary disease chronic obstructive; DNA:missense mutation:exon:p.R75Q(human) 		RGD PMID:10767489 PMID:15463907 RGD:4140475 RGD:4140484 NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO DNA:SNPs: :multiple (human) RGD PMID:19386687 RGD:4891509 NCBI chr15:107,283,081...107,288,041
Ensembl chr15:107,282,927...107,289,103 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 susceptibility ISO DNA:polymorphism (human) RGD PMID:15928955 RGD:4142512 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO DNA:polymorphism (human) RGD PMID:14593914 RGD:4889126 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817 		JBrowse link
G EDN1 endothelin 1 ISO Chronic Allergic Airway Inflammation; protein:increased secretion:bronchoalveolar lavage (mouse) RGD PMID:18631350 RGD:4145074 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G GC GC vitamin D binding protein susceptibility ISO RGD PMID:12096683 RGD:5129516 NCBI chr 8:68,326,293...68,360,262
Ensembl chr 8:68,326,299...68,360,262 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased expression:bronchial epithelium (rat) RGD PMID:19507274 RGD:2308951 NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205 		JBrowse link
G IL10 interleukin 10 ISO protein:decreased expression:lung RGD PMID:19507274 RGD:2308951 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G IL13 interleukin 13 ISO protein:increased expression:Respiratory Mucosa RGD PMID:14582911 RGD:4759835 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093 		JBrowse link
G IL15 interleukin 15 ISO mRNA, protein:increased expression:lung RGD PMID:11742275 RGD:4990461 NCBI chr 8:85,666,963...85,740,980
Ensembl chr 8:85,667,321...85,678,461 		JBrowse link
G MPO myeloperoxidase ISO protein:increased expression:lung RGD PMID:11798689 RGD:5130990 NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO RGD PMID:19938219 RGD:4891494 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G NPY neuropeptide Y ISO CTD Direct Evidence: marker/mechanism CTD PMID:9731035 NCBI chr18:47,985,796...47,993,726
Ensembl chr18:47,985,725...47,992,667 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19263519 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15439
    Pathological Conditions, Signs and Symptoms 12093
      Pathologic Processes 7685
        Inflammation 2479
          bronchitis 88
            Chronic Bronchitis 15
Path 2
Term Annotations click to browse term
  disease 15439
    disease of anatomical entity 15108
      respiratory system disease 4882
        lower respiratory tract disease 2232
          lung disease 2196
            obstructive lung disease 455
              chronic obstructive pulmonary disease 233
                Chronic Bronchitis 15
paths to the root