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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Bone Metastasis
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Accession:DOID:9007482 term browser browse the term
Definition:Transfer of a neoplasm from its primary site to distant bone.
Synonyms:exact_synonym: MBD;   bone metastases;   metastatic bone disease
 xref: EFO:0009870


show annotations for term's descendants           Sort by:
Bone Metastasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type ISO associated with Prostatic Neoplasms; RGD PMID:14669797 RGD:1578303 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Brip1 BRCA1 interacting helicase 1 ISO associated with Breast Neoplasms; human gene in a mouse model RGD PMID:22875853 RGD:11252149 NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 disease_progression ISO associated with hepatocellular carcinoma;protein:increased expression:liver (human) RGD PMID:19508713 RGD:152023653 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISO associated with Breast Neoplasms;mRNA:increased expression:bone element (human) RGD PMID:23861746 RGD:13204736 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Mir34a microRNA 34a susceptibility ISO associated with hepatocellular carcinoma;miRNA:decreased expression:serum, bone RGD PMID:27893432 RGD:14694837 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103 		JBrowse link
G Mmp13 matrix metallopeptidase 13 ISO associated with Carcinoma, Renal Cell; mRNA, protein:increased expression:bone (human) RGD PMID:18709334 RGD:2306080 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Pdgfd platelet derived growth factor D ISO associated with prostate carcinoma RGD PMID:22158043 RGD:13506772 NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19050
    disease of cellular proliferation 7793
      Neoplasms by Site 7249
        Bone Neoplasms 782
          Bone Metastasis 7
Path 2
Term Annotations click to browse term
  disease 19050
    disease of anatomical entity 18384
      musculoskeletal system disease 8479
        connective tissue disease 5951
          bone disease 4402
            Bone Neoplasms 782
              Bone Metastasis 7
paths to the root