RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Myocardial Ischemia
Accession: DOID:9007102
browse the term
Definition: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Synonyms: exact_synonym: Ischemic Heart Disease; Ischemic Heart Diseases; Myocardial Ischemias
related_synonym: Ischemic heart disease, susceptibility to; SUPEROXIDE DISMUTASE, ELEVATED EXTRACELLULAR
primary_id: MESH:D017202
xref: EFO:1001375
GViewer not supported for the selected species.
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Actb
actin beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936765:667,107...670,627
Ensembl chrNW_004936765:667,053...670,672
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Acvr1b
activin A receptor type 1B
ISO
RGD
PMID:14993131
RGD:1580888
NCBI chrNW_004936512:9,407,578...9,449,611
Ensembl chrNW_004936512:9,407,581...9,449,632
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Adipoq
adiponectin, C1Q and collagen domain containing
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16155579
NCBI chrNW_004936578:3,168,599...3,179,369
Ensembl chrNW_004936578:3,168,331...3,171,928
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Adm
adrenomedullin
ISO
protein:increased expression:plasma
RGD
PMID:15350700
RGD:1625302
NCBI chrNW_004936528:8,005,223...8,007,586
Ensembl chrNW_004936528:8,005,189...8,007,643
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Adm2
adrenomedullin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16987513
NCBI chrNW_004936629:360,845...362,499
Ensembl chrNW_004936629:360,305...362,846
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Adrb1
adrenoceptor beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9554809
NCBI chrNW_004936486:4,400,467...4,401,588
Ensembl chrNW_004936486:4,399,915...4,403,149
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Adrb2
adrenoceptor beta 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9554809
NCBI chrNW_004936504:5,985,407...5,987,453
Ensembl chrNW_004936504:5,985,960...5,987,210
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Ager
advanced glycosylation end-product specific receptor
ISO
associated with Diabetes Mellitus, Type 2;DNA:SNP:promoter:-374T>A (human)
RGD
PMID:15896660
RGD:8695969
NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147
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Agt
angiotensinogen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16775501
NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261
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Ak1
adenylate kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936487:15,507,663...15,517,401
Ensembl chrNW_004936487:15,507,498...15,517,469
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Akr1b1
aldo-keto reductase family 1 member B
ISO
protein:increased activity:heart
RGD
PMID:16567803
RGD:1626092
NCBI chrNW_004936579:1,312,175...1,328,397
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Aldh2
aldehyde dehydrogenase 2 family member
ISO
RGD
PMID:18787169
RGD:7241592
NCBI chrNW_004936558:4,362,693...4,387,705
Ensembl chrNW_004936558:4,362,654...4,390,414
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Aldh6a1
aldehyde dehydrogenase 6 family member A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936488:3,320,357...3,340,463
Ensembl chrNW_004936488:3,318,422...3,340,626
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Ampd1
adenosine monophosphate deaminase 1
susceptibility
ISO
associated with congestive heart failure; DNA:SNP:exon 2:34C>T (human)
RGD
PMID:16875916
RGD:329412475
NCBI chrNW_004936627:33,350...57,231
Ensembl chrNW_004936627:33,350...57,166
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Anxa5
annexin A5
ISO
RGD
PMID:8056721
RGD:7241858
NCBI chrNW_004936662:926,302...959,964
Ensembl chrNW_004936662:925,940...939,451
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Aplp2
amyloid beta precursor like protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936572:2,205,527...2,277,786
Ensembl chrNW_004936572:2,205,478...2,277,842
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Apob
apolipoprotein B
ISO
RGD
PMID:9603795
RGD:1578415
NCBI chrNW_004936493:10,509,118...10,549,144
Ensembl chrNW_004936493:10,509,118...10,549,144
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Apoe
apolipoprotein E
susceptibility
ISO
DNA:polymorphism:promoter:-219G>T (human)
RGD
PMID:17006673
RGD:1601238
NCBI chrNW_004936706:1,512,438...1,516,805
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Areg
amphiregulin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936598:1,276,599...1,283,612
Ensembl chrNW_004936598:1,274,565...1,283,746
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Atp1a1
ATPase Na+/K+ transporting subunit alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936627:1,555,151...1,584,370
Ensembl chrNW_004936627:1,554,873...1,584,638
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Axin2
axin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chrNW_004936541:7,155,963...7,242,466
Ensembl chrNW_004936541:7,211,985...7,242,470
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Bax
BCL2 associated X, apoptosis regulator
treatment
ISO
RGD
PMID:22014268
RGD:10054500
NCBI chrNW_004936664:2,968,103...2,973,652
Ensembl chrNW_004936664:2,967,865...2,973,820
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Bcl2
BCL2 apoptosis regulator
treatment
ISO
RGD
PMID:22014268
RGD:10054500
NCBI chrNW_004936497:2,209,136...2,373,580
Ensembl chrNW_004936497:2,210,334...2,210,921
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Bhlhe40
basic helix-loop-helix family member e40
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936577:4,316,099...4,321,193
Ensembl chrNW_004936577:4,315,977...4,322,032
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Bmal1
basic helix-loop-helix ARNT like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936528:5,167,611...5,239,128
Ensembl chrNW_004936528:5,164,481...5,239,128
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Cacna2d2
calcium voltage-gated channel auxiliary subunit alpha2delta 2
ISO
protein:decreased expression:heart
RGD
PMID:28469787
RGD:13513983
NCBI chrNW_004936529:1,889,811...2,023,710
Ensembl chrNW_004936529:1,889,846...2,023,715
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Calr
calreticulin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936659:1,994,695...1,999,070
Ensembl chrNW_004936659:1,994,648...1,999,430
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Camk2d
calcium/calmodulin dependent protein kinase II delta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936563:4,226,412...4,526,139
Ensembl chrNW_004936563:4,227,986...4,526,118
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Canx
calnexin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936739:1,051,853...1,085,658
Ensembl chrNW_004936739:1,051,240...1,086,405
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Ccna2
cyclin A2
ISO
RGD
PMID:17382628
RGD:10054468
NCBI chrNW_004936662:1,073,460...1,079,136
Ensembl chrNW_004936662:1,073,920...1,079,136
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Ccnd1
cyclin D1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
Ensembl chrNW_004936599:973,838...983,316
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Ccnd2
cyclin D2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936606:4,474,801...4,496,158
Ensembl chrNW_004936606:4,474,749...4,496,810
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Cd36
CD36 molecule (CD36 blood group)
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936810:791,823...838,303
Ensembl chrNW_004936810:758,182...838,365
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Cd38
CD38 molecule
ISO
CTD Direct Evidence: marker/mechanism protein:increased activity:ventricle myocardium
CTD RGD
PMID:12111041 PMID:16214533
RGD:2307243
NCBI chrNW_004936477:12,109,761...12,156,037
Ensembl chrNW_004936477:12,108,742...12,156,248
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Cd40
CD40 molecule
treatment
ISO
RGD
PMID:19565716
RGD:11352677
NCBI chrNW_004936514:6,936,915...6,947,246
Ensembl chrNW_004936514:6,936,572...6,947,280
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Cd40lg
CD40 ligand
treatment
ISO
protein:increased expression:myocardium (rat)
RGD
PMID:19204010 PMID:19565716
RGD:11352677 RGD:11352684
NCBI chrNW_004936513:10,607,617...10,620,403
Ensembl chrNW_004936513:10,607,617...10,620,403
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Cdh2
cadherin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936550:6,885,484...7,067,001
Ensembl chrNW_004936550:6,886,706...6,945,056
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Cebpd
CCAAT enhancer binding protein delta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936590:4,919,862...4,920,612
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Ces3
carboxylesterase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936475:17,485,803...17,498,649
Ensembl chrNW_004936475:17,485,826...17,498,260
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Cirbp
cold inducible RNA binding protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936588:636,041...639,564
Ensembl chrNW_004936588:636,026...640,409
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Cpt1b
carnitine palmitoyltransferase 1B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936629:246,876...255,537
Ensembl chrNW_004936629:247,005...255,537
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Crk
CRK proto-oncogene, adaptor protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936538:7,581,453...7,609,543
Ensembl chrNW_004936538:7,581,498...7,609,544
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Crp
C-reactive protein
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:serum
CTD RGD
PMID:11840375 PMID:21122204
RGD:5128547
NCBI chrNW_004936740:885,855...888,854
Ensembl chrNW_004936740:883,272...890,606
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Cryab
crystallin alpha B
ISO
RGD
PMID:11945023
RGD:704398
NCBI chrNW_004936612:2,532,851...2,536,473
Ensembl chrNW_004936612:2,532,812...2,537,495
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Ctnnb1
catenin beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chrNW_004936473:29,999,542...30,034,610
Ensembl chrNW_004936473:29,999,562...30,038,293
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Ctsc
cathepsin C
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936736:1,201,343...1,240,311
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Cttnbp2
cortactin binding protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936589:1,385,342...1,522,911
Ensembl chrNW_004936589:1,393,141...1,522,048
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Cx3cl1
C-X3-C motif chemokine ligand 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936475:9,443,851...9,454,715
Ensembl chrNW_004936475:9,443,733...9,455,062
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Cxcl10
C-X-C motif chemokine ligand 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936676:60,869...63,028
Ensembl chrNW_004936676:60,621...63,106
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Dcn
decorin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936507:7,887,259...7,923,055
Ensembl chrNW_004936507:7,884,654...7,922,961
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Dlat
dihydrolipoamide S-acetyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936612:2,395,452...2,437,592
Ensembl chrNW_004936612:2,393,071...2,437,522
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Dll4
delta like canonical Notch ligand 4
treatment
ISO
RGD
PMID:32089723
RGD:155641250
NCBI chrNW_004936471:4,320,235...4,330,251
Ensembl chrNW_004936471:4,320,933...4,330,253
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Dnm1l
dynamin 1 like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936607:3,576,357...3,632,423
Ensembl chrNW_004936607:3,576,392...3,632,554
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Dusp1
dual specificity phosphatase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936609:2,688,170...2,691,057
Ensembl chrNW_004936609:2,688,181...2,690,408
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Dusp6
dual specificity phosphatase 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936507:6,309,114...6,314,512
Ensembl chrNW_004936507:6,308,886...6,313,935
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Edn1
endothelin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10462014 PMID:11707688 PMID:16306806
NCBI chrNW_004936534:885,489...892,292
Ensembl chrNW_004936534:885,287...891,772
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Ednra
endothelin receptor type A
ISO
RGD
PMID:14729387
RGD:1580946
NCBI chrNW_004936535:1,950,117...2,005,786
Ensembl chrNW_004936535:1,949,941...2,005,910
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Ednrb
endothelin receptor type B
ISO
RGD
PMID:14729387
RGD:1580946
NCBI chrNW_004936511:3,446,864...3,478,434
Ensembl chrNW_004936511:3,446,839...3,478,434
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Egr2
early growth response 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936753:1,958,250...1,962,640
Ensembl chrNW_004936753:1,958,264...1,962,640
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Eif2a
eukaryotic translation initiation factor 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19041636
NCBI chrNW_004936758:960,305...992,152
Ensembl chrNW_004936758:959,734...992,152
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Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19041636
NCBI chrNW_004936712:413,602...454,443
Ensembl chrNW_004936712:414,446...454,449
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Eif4e
eukaryotic translation initiation factor 4E
ISO
RGD
PMID:16439989
RGD:10401145
NCBI chrNW_004936520:3,922,457...3,964,721
Ensembl chrNW_004936520:3,922,339...3,960,359
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Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
ISO
RGD
PMID:16439989
RGD:10401145
NCBI chrNW_004936710:1,446,030...1,461,945
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Eif4g1
eukaryotic translation initiation factor 4 gamma 1
ISO
RGD
PMID:16439989
RGD:10401145
NCBI chrNW_004936578:5,548,526...5,567,220
Ensembl chrNW_004936578:5,548,500...5,567,339
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Eln
elastin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936543:3,135,169...3,165,023
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Ensa
endosulfine alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936580:803,452...859,215
Ensembl chrNW_004936580:851,907...859,213
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Ephx1
epoxide hydrolase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29298899
NCBI chrNW_004936526:2,589,254...2,652,831
Ensembl chrNW_004936526:2,614,059...2,653,286
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Ephx2
epoxide hydrolase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29298899
NCBI chrNW_004936675:350,357...392,919
Ensembl chrNW_004936675:350,342...392,551
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Erbb2
erb-b2 receptor tyrosine kinase 2
ISO
RGD
PMID:15685397
RGD:1580988
NCBI chrNW_004936490:14,887,062...14,910,038
Ensembl chrNW_004936490:14,887,043...14,909,956
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F2rl1
F2R like trypsin receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936549:142,281...153,575
Ensembl chrNW_004936549:141,512...153,602
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F3
coagulation factor III, tissue factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16286589
NCBI chrNW_004936537:4,637,028...4,647,915
Ensembl chrNW_004936537:4,636,667...4,647,916
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F5
coagulation factor V
ISO
DNA:mutation, haplotype: :1691G>A (human)
RGD
PMID:19524925
RGD:4892673
NCBI chrNW_004936481:17,114,441...17,178,902
Ensembl chrNW_004936481:17,114,480...17,178,844
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Fabp5
fatty acid binding protein 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936656:2,881,552...2,886,192
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Fev
FEV transcription factor, ETS family member
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936569:1,402,513...1,408,699
Ensembl chrNW_004936569:1,402,513...1,406,067
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Fez2
fasciculation and elongation protein zeta 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936663:1,576,311...1,637,363
Ensembl chrNW_004936663:1,576,269...1,623,296
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Fgf1
fibroblast growth factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936504:11,590,687...11,684,410
Ensembl chrNW_004936504:11,590,637...11,685,194
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Fxyd1
FXYD domain containing ion transport regulator 1
ISO
RGD
PMID:14597563
RGD:9685466
NCBI chrNW_004936570:1,117,083...1,121,059
Ensembl chrNW_004936570:1,117,816...1,118,860
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Gatm
glycine amidinotransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936471:8,017,611...8,032,703
Ensembl chrNW_004936471:8,017,603...8,032,703
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Gch1
GTP cyclohydrolase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936697:232,048...275,420
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Gclc
glutamate-cysteine ligase catalytic subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936476:7,371,270...7,418,756
Ensembl chrNW_004936476:7,371,149...7,418,958
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Gdf1
growth differentiation factor 1
ISO
protein:increased expression:Left ventricle (human)
RGD
PMID:25726944
RGD:11252030
NCBI chrNW_004936596:2,467,428...2,469,213
Ensembl chrNW_004936596:2,467,431...2,471,476
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Gdf15
growth differentiation factor 15
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936596:2,854,620...2,857,018
Ensembl chrNW_004936596:2,854,841...2,857,111
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Ghr
growth hormone receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936518:235,996...380,225
Ensembl chrNW_004936518:235,990...380,272
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Ghrl
ghrelin and obestatin prepropeptide
disease_progression treatment
ISO
mRNA,protein:increased expression:plasma,myocardia:
RGD
PMID:16626506
RGD:12907503
NCBI chrNW_004936602:3,037,862...3,044,863
Ensembl chrNW_004936602:3,038,549...3,042,506
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Ghsr
growth hormone secretagogue receptor
ISO
mRNA,protein:increased expression,increased activity:myocardia:
RGD
PMID:16626506
RGD:12907503
NCBI chrNW_004936593:268,736...273,623
Ensembl chrNW_004936593:268,350...277,229
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Gk
glycerol kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936553:6,707,148...6,787,245
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Gna12
G protein subunit alpha 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936823:447,979...543,134
Ensembl chrNW_004936823:447,917...543,140
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Gpt
glutamic--pyruvic transaminase
ISO
RGD
PMID:30841448
RGD:401717562
NCBI chrNW_004936470:7,765,810...7,770,837
Ensembl chrNW_004936470:7,765,703...7,768,465
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Gstp1
glutathione S-transferase pi 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936599:2,197,681...2,200,642
Ensembl chrNW_004936599:2,197,634...2,201,050
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Gyg1
glycogenin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936519:6,582,286...6,613,440
Ensembl chrNW_004936519:6,582,286...6,613,630
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Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936493:6,182,786...6,224,601
Ensembl chrNW_004936493:6,182,261...6,224,693
G
Hfe
homeostatic iron regulator
susceptibility
ISO
RGD
PMID:11545759
RGD:1582695
NCBI chrNW_004936671:1,940,079...1,947,574
Ensembl chrNW_004936671:1,940,101...1,947,580
G
Hgf
hepatocyte growth factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12447174
NCBI chrNW_004936734:354,798...428,356
Ensembl chrNW_004936734:356,115...428,779
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Hif1a
hypoxia inducible factor 1 subunit alpha
ISO
mRNA, protein:increased expression:myocardium (rat)
RGD
PMID:17335664
RGD:9068465
NCBI chrNW_004936495:5,770,988...5,816,157
Ensembl chrNW_004936495:5,770,669...5,816,157
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Hivep2
HIVEP zinc finger 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936625:3,219,260...3,301,361
Ensembl chrNW_004936625:3,267,947...3,301,369
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Hk1
hexokinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936521:9,067,062...9,139,112
Ensembl chrNW_004936521:9,066,999...9,159,793
G
Hk2
hexokinase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936556:1,054,143...1,113,425
Ensembl chrNW_004936556:1,054,021...1,113,450
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Hmgb1
high mobility group box 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936472:25,236,728...25,246,585
Ensembl chrNW_004936472:25,236,728...25,246,580
G
Hmgcs2
3-hydroxy-3-methylglutaryl-CoA synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936627:4,451,847...4,473,163
Ensembl chrNW_004936627:4,451,823...4,473,223
G
Hmox1
heme oxygenase 1
susceptibility
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:15064108 PMID:15734859 PMID:16214533
RGD:1582713 RGD:1598399
NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311
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Hspa2
heat shock protein family A (Hsp70) member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936495:8,243,369...8,246,082
G
Hspa9
heat shock protein family A (Hsp70) member 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936531:7,702,186...7,716,428
Ensembl chrNW_004936531:7,702,695...7,716,380
G
Hspd1
heat shock protein family D (Hsp60) member 1
ISO
protein:increased expression:heart
RGD
PMID:12872233
RGD:1624250
NCBI chrNW_004936506:1,678,069...1,687,632
G
Icam1
intercellular adhesion molecule 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936659:616,570...627,172
Ensembl chrNW_004936659:616,752...627,174
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Id1
inhibitor of DNA binding 1, HLH protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936485:18,610,721...18,611,889
Ensembl chrNW_004936485:18,610,665...18,612,059
G
Id3
inhibitor of DNA binding 3, HLH protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936474:8,758,098...8,759,684
Ensembl chrNW_004936474:8,758,030...8,759,823
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Ifngr1
interferon gamma receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936560:4,519,858...4,545,763
Ensembl chrNW_004936560:4,519,474...4,545,796
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Igf1
insulin like growth factor 1
severity
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:16214533 PMID:16698918 PMID:16793032
RGD:1598425 RGD:1598426
NCBI chrNW_004936492:11,709,623...11,784,028
Ensembl chrNW_004936492:11,709,222...11,778,351
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Igfbp3
insulin like growth factor binding protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936478:20,511,490...20,518,251
Ensembl chrNW_004936478:20,510,137...20,518,306
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Il1a
interleukin 1 alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936783:1,210,715...1,218,315
Ensembl chrNW_004936783:1,210,809...1,218,315
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Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165
G
Il6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16286589
NCBI chrNW_004936549:7,015,595...7,016,246
G
Il6st
interleukin 6 cytokine family signal transducer
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936480:11,867,573...11,913,563
Ensembl chrNW_004936480:11,884,582...11,909,635
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Irf1
interferon regulatory factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936647:2,686,247...2,693,633
Ensembl chrNW_004936647:2,686,414...2,693,636
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Itgav
integrin subunit alpha V
ISO
RGD
PMID:11997283
RGD:1582453
NCBI chrNW_004936506:10,750,116...10,839,018
Ensembl chrNW_004936506:10,750,101...10,839,303
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Jak2
Janus kinase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15746188 PMID:16214533
NCBI chrNW_004936503:111,722...243,627
Ensembl chrNW_004936503:110,963...241,867
G
Junb
JunB proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936659:1,890,786...1,892,619
Ensembl chrNW_004936659:1,891,080...1,892,123
G
Kcnj11
potassium inwardly rectifying channel subfamily J member 11
ISO
RGD
PMID:26591689
RGD:12790977
NCBI chrNW_004936528:1,685,015...1,688,220
Ensembl chrNW_004936528:1,685,924...1,687,096
G
Kcnj8
potassium inwardly rectifying channel subfamily J member 8
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:9399952 PMID:16214533 PMID:26591689
RGD:12790977 RGD:1598652
NCBI chrNW_004936548:5,125,583...5,132,490
Ensembl chrNW_004936548:5,125,555...5,133,078
G
Kcnk2
potassium two pore domain channel subfamily K member 2
ISO
mRNA:increased expression:heart left ventricle, epicardium, endocardium (rat)
RGD
PMID:24705172
RGD:9831164
NCBI chrNW_004936628:3,155,261...3,284,375
Ensembl chrNW_004936628:3,154,109...3,345,660
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Kcnmb1
potassium calcium-activated channel subfamily M regulatory beta subunit 1
no_association
ISO
RGD
PMID:16155733
RGD:1581719
NCBI chrNW_004936609:4,451,526...4,458,665
Ensembl chrNW_004936609:4,451,492...4,458,712
G
Kdr
kinase insert domain receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936482:17,537,697...17,581,320
Ensembl chrNW_004936482:17,538,864...17,581,002
G
Kitlg
KIT ligand
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936507:5,566,144...5,650,412
Ensembl chrNW_004936507:5,565,821...5,650,828
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Klf4
KLF transcription factor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936559:5,105,456...5,109,970
Ensembl chrNW_004936559:5,105,463...5,109,970
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Lepr
leptin receptor
susceptibility
ISO
DNA:missense mutation:CDS:p.Q223R (human)
RGD
PMID:19337797
RGD:2311129
NCBI chrNW_004936591:5,771,371...5,846,177
Ensembl chrNW_004936591:5,774,326...5,836,444
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LOC101956126
heat shock 70 kDa protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936727:1,732,323...1,735,128
G
LOC101959727
cytochrome b-c1 complex subunit Rieske, mitochondrial
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936570:6,044,969...6,051,046
G
LOC101965209
cytochrome c oxidase subunit 5B, mitochondrial
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936744:921,888...923,803
G
LOC101972766
tubulin alpha-1A chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936512:6,959,656...6,964,299
Ensembl chrNW_004936512:6,958,985...6,964,299
G
Ltbp2
latent transforming growth factor beta binding protein 2
ISO
mRNA:increased expression:myocardium (human)
RGD
PMID:17343875
RGD:156451374
NCBI chrNW_004936488:3,682,044...3,790,988
Ensembl chrNW_004936488:3,685,334...3,791,063
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Map2k3
mitogen-activated protein kinase kinase 3
ISO
RGD
PMID:20550965
RGD:7243113
NCBI chrNW_004936741:362,682...386,633
Ensembl chrNW_004936741:362,387...386,678
G
Map3k8
mitogen-activated protein kinase kinase kinase 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936613:3,791,684...3,813,857
Ensembl chrNW_004936613:3,791,681...3,813,892
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Mapk14
mitogen-activated protein kinase 14
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936476:23,237,762...23,310,211
Ensembl chrNW_004936476:23,237,277...23,310,232
G
Mapre1
microtubule associated protein RP/EB family member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936485:19,577,859...19,608,036
G
Mb
myoglobin
susceptibility
ISO
protein:decreased expression:subendocardium
RGD
PMID:3315739 PMID:12935692 PMID:15762290
RGD:1582393 RGD:1582426 RGD:485874381
NCBI chrNW_004936492:4,890,871...4,897,665
Ensembl chrNW_004936492:4,890,871...4,897,665
G
Meox2
mesenchyme homeobox 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936546:2,239,442...2,304,099
Ensembl chrNW_004936546:2,239,442...2,304,099
G
Mfn1
mitofusin 1
treatment
ISO
RGD
PMID:27491814
RGD:12910831
NCBI chrNW_004936566:3,737,315...3,775,894
Ensembl chrNW_004936566:3,737,315...3,775,693
G
Mfn2
mitofusin 2
treatment
ISO
RGD
PMID:27491814
RGD:12910831
NCBI chrNW_004936474:767,754...795,258
Ensembl chrNW_004936474:767,671...796,556
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Mpo
myeloperoxidase
ISO
Acute Coronary Syndrome; protein:increased expression:plasma
RGD
PMID:21226709
RGD:5130961
NCBI chrNW_004936490:4,809,773...4,819,070
Ensembl chrNW_004936490:4,809,631...4,819,070
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Msn
moesin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936635:2,390,390...2,461,870
Ensembl chrNW_004936635:2,389,823...2,461,930
G
Msr1
macrophage scavenger receptor 1
disease_progression
ISO
mRNA:increased expression:blood, mononuclear cell
RGD
PMID:17945237
RGD:2306126
NCBI chrNW_004936573:5,345,282...5,391,946
Ensembl chrNW_004936573:5,328,526...5,388,901
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Nedd4
NEDD4 E3 ubiquitin protein ligase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936471:17,254,777...17,374,725
Ensembl chrNW_004936471:17,252,234...17,374,804
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Nfkbia
NFKB inhibitor alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936494:9,537,793...9,541,187
Ensembl chrNW_004936494:9,537,008...9,541,612
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Nos3
nitric oxide synthase 3
susceptibility
ISO
DNA:duplication, snp:intron, cds:g.IVS4?-?+27, p.E298D (human) ClinVar Annotator: match by term: Ischemic heart disease, susceptibility to
RGD ClinVar
PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 PMID:11026457 PMID:11354626 PMID:11394896 PMID:11745998 PMID:15007011 PMID:16059745 PMID:16813604 PMID:17165044 PMID:24033266 PMID:25741868 More...
RGD:7777100
NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534
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Notch1
notch receptor 1
treatment
ISO
RGD
PMID:32089723
RGD:155641250
NCBI chrNW_004936669:1,292,016...1,334,061
Ensembl chrNW_004936669:1,292,088...1,332,428
G
Nppa
natriuretic peptide A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1830552
NCBI chrNW_004936474:671,362...673,610
G
Nptn
neuroplastin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936471:32,726,953...32,813,429
Ensembl chrNW_004936471:32,744,766...32,813,543
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Nr1h3
nuclear receptor subfamily 1 group H member 3
susceptibility
ISO
DNA:SNPs, haplotype:promoter:c.-115G>A, c.-840C>A (rs12221497, rs61896015) (human)
RGD
PMID:21903943
RGD:401842365
NCBI chrNW_004936562:1,937,665...1,946,680
Ensembl chrNW_004936562:1,937,667...1,946,669
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Nr4a1
nuclear receptor subfamily 4 group A member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936512:9,486,096...9,508,338
Ensembl chrNW_004936512:9,499,754...9,508,423
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Opa1
OPA1 mitochondrial dynamin like GTPase
treatment
ISO
RGD
PMID:27491814
RGD:12910831
NCBI chrNW_004936711:1,027,531...1,113,796
Ensembl chrNW_004936711:1,032,935...1,106,847
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P4hb
prolyl 4-hydroxylase subunit beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936594:5,368,199...5,379,215
Ensembl chrNW_004936594:5,367,816...5,379,252
G
Pde4b
phosphodiesterase 4B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936591:5,152,491...5,666,728
Ensembl chrNW_004936591:5,152,441...5,573,129
G
Pdha1
pyruvate dehydrogenase E1 subunit alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936844:889,720...906,631
Ensembl chrNW_004936844:889,635...909,586
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Pdk4
pyruvate dehydrogenase kinase 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936585:4,701,012...4,713,421
Ensembl chrNW_004936585:4,700,418...4,714,450
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Pdlim5
PDZ and LIM domain 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936687:1,944,095...2,152,501
Ensembl chrNW_004936687:1,944,095...2,152,529
G
Pebp1
phosphatidylethanolamine binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936668:2,316,661...2,323,015
G
Penk
proenkephalin
treatment
ISO
RGD
PMID:21247719
RGD:10003103
NCBI chrNW_004936496:3,016,247...3,021,726
Ensembl chrNW_004936496:3,016,218...3,021,738
G
Pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936484:8,356,523...8,434,529
Ensembl chrNW_004936484:8,356,487...8,434,925
G
Pfkm
phosphofructokinase, muscle
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936512:6,006,247...6,031,939
Ensembl chrNW_004936512:6,006,046...6,032,899
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Pgf
placental growth factor
ISO
RGD
PMID:18192038
RGD:6483613
NCBI chrNW_004936488:4,098,187...4,111,108
Ensembl chrNW_004936488:4,098,225...4,111,142
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Pgm1
phosphoglucomutase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936692:1,160,836...1,221,270
Ensembl chrNW_004936692:1,160,623...1,221,746
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Pla2g2a
phospholipase A2 group IIA
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936474:6,091,978...6,095,961
Ensembl chrNW_004936474:6,091,941...6,096,057
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Plcd1
phospholipase C delta 1
ISO
protein:decreased expression:heart
RGD
PMID:15276620
RGD:2300429
NCBI chrNW_004936473:27,364,404...27,387,337
Ensembl chrNW_004936473:27,364,389...27,387,412
G
Pomc
proopiomelanocortin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10908253
NCBI chrNW_004936493:7,060,747...7,065,276
Ensembl chrNW_004936493:7,061,587...7,065,109
G
Ppat
phosphoribosyl pyrophosphate amidotransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936482:18,606,124...18,648,989
Ensembl chrNW_004936482:18,606,124...18,648,681
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Ppm1b
protein phosphatase, Mg2+/Mn2+ dependent 1B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936508:7,732,724...7,804,964
Ensembl chrNW_004936508:7,722,396...7,805,036
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Ppp2ca
protein phosphatase 2 catalytic subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936647:1,031,118...1,055,961
Ensembl chrNW_004936647:1,031,119...1,055,149
G
Ppp3r1
protein phosphatase 3 regulatory subunit B, alpha
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16214533
RGD:1580707
NCBI chrNW_004936491:12,623,931...12,654,463
Ensembl chrNW_004936491:12,623,349...12,654,502 Ensembl chrNW_004936491:12,623,349...12,654,502
G
Prdx6
peroxiredoxin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936481:14,223,422...14,233,634
Ensembl chrNW_004936481:14,222,696...14,233,641
G
Prkcd
protein kinase C delta
ISO
mRNA, protein:increased expression, altered phosphorylation:heart
RGD
PMID:16924416
RGD:1642550
NCBI chrNW_004936473:3,892,625...3,923,467
Ensembl chrNW_004936473:3,892,366...3,923,515
G
Prkce
protein kinase C epsilon
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936508:6,018,374...6,495,216
Ensembl chrNW_004936508:6,017,551...6,494,427
G
Psmb5
proteasome 20S subunit beta 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936722:1,285,488...1,293,637
Ensembl chrNW_004936722:1,285,482...1,295,106
G
Ptpra
protein tyrosine phosphatase receptor type A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936485:15,745,054...15,872,377
Ensembl chrNW_004936485:15,744,205...15,872,995
G
Pygb
glycogen phosphorylase B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936620:533,574...575,893
Ensembl chrNW_004936620:532,634...575,916
G
Pygm
glycogen phosphorylase, muscle associated
ISO
RGD
PMID:10498852
RGD:1599991
NCBI chrNW_004936599:4,551,164...4,564,109
Ensembl chrNW_004936599:4,551,032...4,564,154
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Rab12
RAB12, member RAS oncogene family
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936670:2,315,930...2,338,489
Ensembl chrNW_004936670:2,315,442...2,338,509
G
Rab1b
RAB1B, member RAS oncogene family
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936599:3,317,258...3,324,208
Ensembl chrNW_004936599:3,317,258...3,324,213
G
Rab5a
RAB5A, member RAS oncogene family
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936473:12,238,226...12,267,339
Ensembl chrNW_004936473:12,238,156...12,269,089
G
Rab7a
RAB7A, member RAS oncogene family
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936798:297,600...304,929
Ensembl chrNW_004936798:296,066...305,176
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Ralbp1
ralA binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936626:1,832,703...1,851,486
Ensembl chrNW_004936626:1,832,584...1,851,467
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Ramp2
receptor activity modifying protein 2
ISO
mRNA:increased expression:ventricle myocardium
RGD
PMID:16987513
RGD:1642684
NCBI chrNW_004936490:17,479,899...17,481,788
Ensembl chrNW_004936490:17,479,650...17,482,716
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Rgcc
regulator of cell cycle
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936667:232,807...245,131
Ensembl chrNW_004936667:232,782...245,131
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Rhoc
ras homolog family member C
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936690:1,255,126...1,258,288
G
Rln3
relaxin 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16112403
NCBI chrNW_004936659:2,703,024...2,704,664
Ensembl chrNW_004936659:2,703,024...2,704,664
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Rpl17
ribosomal protein L17
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936497:13,457,328...13,460,606
G
Rsad2
radical S-adenosyl methionine domain containing 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936532:3,921,824...3,936,027
Ensembl chrNW_004936532:3,921,807...3,936,042
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Rtn1
reticulon 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936495:3,933,652...4,158,269
Ensembl chrNW_004936495:3,933,605...4,158,571
G
Rxrg
retinoid X receptor gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936481:19,789,753...19,826,665
Ensembl chrNW_004936481:19,789,641...19,826,698
G
Ryr2
ryanodine receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936484:15,402,488...15,825,410
Ensembl chrNW_004936484:15,403,819...15,824,441
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S100a1
S100 calcium binding protein A1
ISO
protein:increased expression:serum (human)
RGD
PMID:10924368
RGD:1579977
NCBI chrNW_004936580:3,429,697...3,433,567
Ensembl chrNW_004936580:3,427,212...3,434,577
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Sele
selectin E
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936481:16,915,203...16,921,840
Ensembl chrNW_004936481:16,915,182...16,921,840
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Selp
selectin P
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936481:17,076,660...17,112,501
Ensembl chrNW_004936481:17,076,536...17,107,963
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Serpinf1
serpin family F member 1
ISO
associated with chronic kidney disease;protein:increased expression:blood (human)
RGD
PMID:11045282
RGD:30296653
NCBI chrNW_004936538:7,885,816...7,898,308
Ensembl chrNW_004936538:7,885,475...7,899,113
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Sfrp4
secreted frizzled related protein 4
ISO
RGD
PMID:20528676
RGD:4107721
NCBI chrNW_004936478:13,257,183...13,266,972
Ensembl chrNW_004936478:13,257,801...13,266,701
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Slc6a6
solute carrier family 6 member 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936602:233,753...274,982
G
Slc8a1
solute carrier family 8 member A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936508:10,894,918...11,256,084
Ensembl chrNW_004936508:10,968,656...11,253,070
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Slc9a1
solute carrier family 9 member A1
ISO
RGD
PMID:17356886
RGD:1625560
NCBI chrNW_004936474:11,460,266...11,517,420
Ensembl chrNW_004936474:11,459,929...11,517,478
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Snap23
synaptosome associated protein 23
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936471:5,784,070...5,818,644
Ensembl chrNW_004936471:5,784,054...5,820,571
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Socs3
suppressor of cytokine signaling 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936594:2,932,297...2,935,358
Ensembl chrNW_004936594:2,933,747...2,934,451
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Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:15681709 PMID:16214533
RGD:1581233
NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781
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Sox2
SRY-box transcription factor 2
ISO
RGD
PMID:34321385
RGD:155882552
NCBI chrNW_004936566:1,630,698...1,632,607
Ensembl chrNW_004936566:1,631,822...1,632,613
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Sparc
secreted protein acidic and cysteine rich
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936515:11,026,156...11,046,812
Ensembl chrNW_004936515:11,025,724...11,046,849
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Tap1
transporter 1, ATP binding cassette subfamily B member
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936476:25,899,514...25,907,690
Ensembl chrNW_004936476:25,899,339...25,907,695
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Tcf7l2
transcription factor 7 like 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29394407
NCBI chrNW_004936486:3,473,877...3,660,565
Ensembl chrNW_004936486:3,473,843...3,660,576
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Tfrc
transferrin receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936784:696,738...728,385
Ensembl chrNW_004936784:696,713...728,543
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Tgoln2
trans-golgi network protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936712:1,837,235...1,845,482
G
Tle4
TLE family member 4, transcriptional corepressor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936632:3,077,594...3,213,763
Ensembl chrNW_004936632:3,077,563...3,213,763
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Tle5
TLE family member 5, transcriptional modulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936588:1,746,300...1,753,727
Ensembl chrNW_004936588:1,746,843...1,752,275
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Tmed2
transmembrane p24 trafficking protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936558:1,223,114...1,258,699
Ensembl chrNW_004936558:1,223,114...1,231,479
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Tmpo
thymopoietin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936492:14,972,391...15,000,115
Ensembl chrNW_004936492:14,971,968...15,000,060
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533 PMID:16775501
NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
G
Tnnt2
troponin T2, cardiac type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10789933
NCBI chrNW_004936567:3,052,167...3,069,077
Ensembl chrNW_004936567:3,056,845...3,068,887
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Ttn
titin
ISO
RGD
PMID:12221049
RGD:1580780
NCBI chrNW_004936509:7,733,426...7,999,503
G
Txnip
thioredoxin interacting protein
ISO
RGD
PMID:16172122
RGD:1580789
NCBI chrNW_004936867:722,544...726,595
Ensembl chrNW_004936867:722,514...726,617
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Txnrd1
thioredoxin reductase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936492:10,185,096...10,244,466
Ensembl chrNW_004936492:10,187,206...10,225,989
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Ugcg
UDP-glucose ceramide glucosyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936559:1,475,684...1,513,273
Ensembl chrNW_004936559:1,475,592...1,513,273
G
Vcam1
vascular cell adhesion molecule 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936748:785,491...802,791
Ensembl chrNW_004936748:785,455...803,048
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Vegfa
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:9860779 PMID:14503966 PMID:14583313 PMID:15347709 PMID:16214533
NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673
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Zeb1
zinc finger E-box binding homeobox 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936574:17,643...175,762
Ensembl chrNW_004936574:17,684...178,293
G
Zfp36
ZFP36 ring finger protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16214533
NCBI chrNW_004936661:2,251,148...2,253,527
Ensembl chrNW_004936661:2,250,665...2,253,787
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Actg1
actin gamma 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936594:5,170,711...5,173,251
Ensembl chrNW_004936594:5,170,711...5,173,247
G
Ager
advanced glycosylation end-product specific receptor
ISO
protein:increased expression:serum (human)
RGD
PMID:21663912
RGD:5508825
NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147
G
Arhgdib
Rho GDP dissociation inhibitor beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936587:2,471,344...2,549,765
Ensembl chrNW_004936587:2,470,867...2,549,861
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Capzb
capping actin protein of muscle Z-line subunit beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936474:5,594,193...5,656,665
Ensembl chrNW_004936474:5,594,152...5,709,315
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Ccn1
cellular communication network factor 1
susceptibility
ISO
DNA:SNP,haplotypes:5'utr: (rs6576776) (human)
RGD
PMID:33906697
RGD:329845569
NCBI chrNW_004936608:152,174...155,123
Ensembl chrNW_004936608:151,838...155,358
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Cd40
CD40 molecule
ISO
DNA:SNP:5' utr:rs1883832 (human)
RGD
PMID:21091218
RGD:5490523
NCBI chrNW_004936514:6,936,915...6,947,246
Ensembl chrNW_004936514:6,936,572...6,947,280
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Cd40lg
CD40 ligand
treatment
ISO
associated with Anxiety Disorders;protein:increased expression:serum
RGD
PMID:20170788 PMID:31624788
RGD:21081509 RGD:5490548
NCBI chrNW_004936513:10,607,617...10,620,403
Ensembl chrNW_004936513:10,607,617...10,620,403
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Ckb
creatine kinase B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15966572
NCBI chrNW_004936621:1,612,398...1,615,821
Ensembl chrNW_004936621:1,612,393...1,615,822
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Ckm
creatine kinase, M-type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15966572
NCBI chrNW_004936706:1,792,298...1,801,063
Ensembl chrNW_004936706:1,790,958...1,801,139
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Crp
C-reactive protein
ISO
protein:increased expression: : CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15966572 PMID:18973750 PMID:21794939 PMID:23305094
RGD:6907401 RGD:9491837
NCBI chrNW_004936740:885,855...888,854
Ensembl chrNW_004936740:883,272...890,606
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Eno1
enolase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936623:3,115,357...3,130,289
Ensembl chrNW_004936623:3,115,081...3,128,183
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F2
coagulation factor II, thrombin
ISO
RGD
PMID:21496882
RGD:5147784
NCBI chrNW_004936562:2,371,725...2,388,617
Ensembl chrNW_004936562:2,372,044...2,388,650
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Fasn
fatty acid synthase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23305094
NCBI chrNW_004936594:5,591,785...5,609,886
Ensembl chrNW_004936594:5,592,609...5,608,972
G
Fto
FTO alpha-ketoglutarate dependent dioxygenase
susceptibility
ISO
DNA:SNP: :rs17817449 (human)
RGD
PMID:20362563
RGD:329813083
NCBI chrNW_004936475:6,321,725...6,689,410
Ensembl chrNW_004936475:6,321,711...6,689,588
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Gapdh
glyceraldehyde-3-phosphate dehydrogenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936709:1,243,149...1,247,782
Ensembl chrNW_004936709:1,243,147...1,247,903
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Gch1
GTP cyclohydrolase 1
ISO
DNa:SNP: :rs3783637 (human)
RGD
PMID:26232608
RGD:329961571
NCBI chrNW_004936697:232,048...275,420
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Gp6
glycoprotein VI platelet
disease_progression
ISO
protein:increased expression:platelet (human)
RGD
PMID:17340467 PMID:20071043
RGD:401794408 RGD:401824680
NCBI chrNW_004936886:295,950...310,614
Ensembl chrNW_004936886:296,025...310,614
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Gpx1
glutathione peroxidase 1
ISO
mRNA, protein:increased expression:blood, plasma
RGD
PMID:28298473
RGD:401827171
NCBI chrNW_004936529:997,943...999,123
Ensembl chrNW_004936529:998,150...998,987
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Gpx3
glutathione peroxidase 3
ISO
mRNA, protein:increased expression:blood, plasma
RGD
PMID:28298473
RGD:401827171
NCBI chrNW_004936647:3,904,787...3,914,223
Ensembl chrNW_004936647:3,906,113...3,913,498
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Gpx4
glutathione peroxidase 4
ISO
mRNA, protein:increased expression:blood, plasma
RGD
PMID:28298473
RGD:401827171
NCBI chrNW_004936588:506,101...508,469
Ensembl chrNW_004936588:506,147...508,101
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Gsn
gelsolin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936487:9,749,755...9,802,787
Ensembl chrNW_004936487:9,764,944...9,802,841
G
Gstp1
glutathione S-transferase pi 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936599:2,197,681...2,200,642
Ensembl chrNW_004936599:2,197,634...2,201,050
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Hspa8
heat shock protein family A (Hsp70) member 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936542:7,577,192...7,581,598
Ensembl chrNW_004936542:7,577,149...7,581,923
G
Hspd1
heat shock protein family D (Hsp60) member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936506:1,678,069...1,687,632
G
Il6
interleukin 6
treatment
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:blood serum (human)
CTD RGD
PMID:23305094 PMID:32178736
RGD:155230830
NCBI chrNW_004936549:7,015,595...7,016,246
G
Itgb3
integrin subunit beta 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15840736
NCBI chrNW_004936541:2,822,789...2,871,069
Ensembl chrNW_004936541:2,815,738...2,871,035
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Ldhb
lactate dehydrogenase B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936548:5,224,905...5,244,708
Ensembl chrNW_004936548:5,227,666...5,244,525
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LOC101956126
heat shock 70 kDa protein 1
ISO
DNA:SNP: :190G>C(human)
RGD
PMID:21849784
RGD:7257650
NCBI chrNW_004936727:1,732,323...1,735,128
G
LOC101973343
tubulin alpha-1C chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936512:7,026,107...7,033,804
G
Mmp9
matrix metallopeptidase 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20981132
NCBI chrNW_004936514:7,038,240...7,045,873
Ensembl chrNW_004936514:7,037,639...7,045,793
G
Ogg1
8-oxoguanine DNA glycosylase
susceptibility
ISO
DNA:SNP,haplotype: :p.S326C (rs1052133) (human)
RGD
PMID:23368530
RGD:401827273
NCBI chrNW_004936602:3,411,106...3,418,826
Ensembl chrNW_004936602:3,413,282...3,418,831
G
Pappa
pappalysin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11586954
NCBI chrNW_004936487:5,000,279...5,379,786
Ensembl chrNW_004936487:5,144,044...5,376,367
G
Pdia3
protein disulfide isomerase family A member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936471:6,809,181...6,834,189
Ensembl chrNW_004936471:6,809,195...6,836,169
G
Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
protein:increased expression:coronary artery, intima (human)
RGD
PMID:22336504
RGD:6767292
NCBI chrNW_004936541:4,873,459...4,919,787
Ensembl chrNW_004936541:4,873,182...4,937,500
G
Phactr1
phosphatase and actin regulator 1
exacerbates
ISO
protein:increased expression:monocyte (human)
RGD
PMID:32857129
RGD:401900689
NCBI chrNW_004936534:42,354...323,735
Ensembl chrNW_004936534:42,433...536,171
G
Pla2g7
phospholipase A2 group VII
disease_progression
ISO
RGD
PMID:22024276
RGD:6482773
NCBI chrNW_004936476:13,609,847...13,646,174
Ensembl chrNW_004936476:13,609,374...13,649,998
G
Pon1
paraoxonase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26241956
NCBI chrNW_004936585:4,954,871...4,979,560
Ensembl chrNW_004936585:4,954,869...4,979,591
G
Psmb1
proteasome 20S subunit beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004937098:67,298...80,019
Ensembl chrNW_004937098:66,832...81,708
G
Rab7b
RAB7B, member RAS oncogene family
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936557:6,504,562...6,519,219
Ensembl chrNW_004936557:6,504,509...6,519,219
G
Rbp4
retinol binding protein 4
severity onset
ISO
protein:increased expression:blood plasma (human) protein:increased expression:blood serum (human)
RGD
PMID:25437889 PMID:32449048
RGD:329845573 RGD:329845576
NCBI chrNW_004936601:1,401,215...1,410,195
Ensembl chrNW_004936601:1,402,691...1,410,208
G
Serpinc1
serpin family C member 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:7923645
NCBI chrNW_004936481:13,981,014...13,993,750
Ensembl chrNW_004936481:13,981,019...13,993,634
G
Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781
G
Tlr4
toll like receptor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20981132
NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095
G
Tnf
tumor necrosis factor
treatment
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:blood serum (human)
CTD RGD
PMID:20981132 PMID:32178736
RGD:155230830
NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
G
Tnni3
troponin I3, cardiac type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15966572
NCBI chrNW_004936886:437,754...440,925
Ensembl chrNW_004936886:437,754...440,458
G
Tnnt2
troponin T2, cardiac type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15966572
NCBI chrNW_004936567:3,052,167...3,069,077
Ensembl chrNW_004936567:3,056,845...3,068,887
G
Tpm4
tropomyosin 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936596:4,406,301...4,423,775
Ensembl chrNW_004936596:4,406,283...4,418,932
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Tubb1
tubulin beta 1 class VI
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936530:1,500,415...1,506,187
Ensembl chrNW_004936530:1,500,437...1,506,071
G
Vcl
vinculin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936521:5,051,077...5,163,036
Ensembl chrNW_004936521:5,050,900...5,163,086
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Vim
vimentin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21751358
NCBI chrNW_004936520:10,051,692...10,059,324
Ensembl chrNW_004936520:10,052,012...10,059,182
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Arhgap17
Rho GTPase activating protein 17
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004936501:9,256,950...9,307,228
Ensembl chrNW_004936501:9,257,654...9,307,230
G
Bax
BCL2 associated X, apoptosis regulator
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004936664:2,968,103...2,973,652
Ensembl chrNW_004936664:2,967,865...2,973,820
G
C3
complement C3
ISO
RGD
PMID:26476955
RGD:11552746
NCBI chrNW_004936588:3,985,732...4,023,221
G
Cacng4
calcium voltage-gated channel auxiliary subunit gamma 4
ISO
mRNA:decreased expression:blood:
RGD
PMID:27746059
RGD:13524557
NCBI chrNW_004936541:6,051,021...6,062,275
Ensembl chrNW_004936541:6,053,391...6,059,505
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Casp3
caspase 3
treatment
ISO
RGD
PMID:26550220
RGD:13782284
NCBI chrNW_004936554:4,571,072...4,593,765
G
Casp7
caspase 7
treatment
ISO
RGD
PMID:26550220
RGD:13782284
NCBI chrNW_004936486:4,082,664...4,114,942
Ensembl chrNW_004936486:4,088,372...4,114,955
G
Ccn1
cellular communication network factor 1
ameliorates
ISO
RGD
PMID:30371213
RGD:329845516
NCBI chrNW_004936608:152,174...155,123
Ensembl chrNW_004936608:151,838...155,358
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Dram1
DNA damage regulated autophagy modulator 1
ameliorates
ISO
mRNA,protein:decreased expression:heart
RGD
PMID:30144448
RGD:407571674
NCBI chrNW_004936492:12,171,642...12,206,845
Ensembl chrNW_004936492:12,169,815...12,206,845
G
Dsc2
desmocollin 2
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004936682:2,057,331...2,091,034
Ensembl chrNW_004936682:2,057,190...2,164,429
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
treatment
ISO
RGD
PMID:23054911
RGD:405650598
NCBI chrNW_004936488:4,384,710...4,388,118
Ensembl chrNW_004936488:4,384,705...4,388,122
G
Fto
FTO alpha-ketoglutarate dependent dioxygenase
ISO
mRNA:increased expression:blood
RGD
PMID:35693610
RGD:329901852
NCBI chrNW_004936475:6,321,725...6,689,410
Ensembl chrNW_004936475:6,321,711...6,689,588
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Gata5
GATA binding protein 5
susceptibility
ISO
DNA:SNPs:promoter:rs80197101, rs77067995 (human)
RGD
PMID:33684162
RGD:155260335
NCBI chrNW_004936514:10,061,675...10,070,541
Ensembl chrNW_004936514:10,061,675...10,070,541
G
Gp6
glycoprotein VI platelet
sexual_dimorphism ameliorates
ISO
DNA:missense mutation:intron 1, intron 5: (rs1671207, rs11084382) (human) DNA:missense mutation:CDS:p.S219P (rs1613662) (human)
RGD
PMID:20227257
RGD:401794138
NCBI chrNW_004936886:295,950...310,614
Ensembl chrNW_004936886:296,025...310,614
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Gpx3
glutathione peroxidase 3
ISO
protein:increased expression:plasma
RGD
PMID:28374671
RGD:401827832
NCBI chrNW_004936647:3,904,787...3,914,223
Ensembl chrNW_004936647:3,906,113...3,913,498
G
Gsk3b
glycogen synthase kinase 3 beta
treatment ameliorates
ISO
RGD
PMID:26591365 PMID:32068187
RGD:13792778 RGD:267358468
NCBI chrNW_004936536:6,730,070...6,893,818
Ensembl chrNW_004936536:6,730,062...6,894,303
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Idh2
isocitrate dehydrogenase (NADP(+)) 2
ISO
ClinVar Annotator: match by term: Acute myocardial infarction
ClinVar
NCBI chrNW_004936483:15,845,777...15,864,341
Ensembl chrNW_004936483:15,845,792...15,864,341
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Ifng
interferon gamma
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452
G
Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004936809:1,280,254...1,306,964
Ensembl chrNW_004936809:1,257,654...1,301,813
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Il10
interleukin 10
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004936557:5,834,874...5,838,502
Ensembl chrNW_004936557:5,834,874...5,838,502
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Il17a
interleukin 17A
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004936476:8,621,860...8,625,008
Ensembl chrNW_004936476:8,621,860...8,625,008
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Il1b
interleukin 1 beta
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165
G
Il1rl1
interleukin 1 receptor like 1
ISO
RGD
PMID:24837094
RGD:40813741
NCBI chrNW_004936713:1,020,969...1,035,012
Ensembl chrNW_004936713:1,021,044...1,035,039
G
Il33
interleukin 33
ISO
RGD
PMID:24837094
RGD:40813741
NCBI chrNW_004936539:763,755...791,461
Ensembl chrNW_004936539:623,248...791,470
G
Il6
interleukin 6
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004936549:7,015,595...7,016,246
G
Itgam
integrin subunit alpha M
treatment
ISO
RGD
PMID:21238619
RGD:329901664
NCBI chrNW_004936543:8,460,526...8,508,524
Ensembl chrNW_004936543:8,461,307...8,508,524
G
Kif6
kinesin family member 6
ISO
DNA:SNP: :p.W719R (rs20455) (human)
RGD
PMID:20044086
RGD:243048455
NCBI chrNW_004936476:19,937,141...20,311,988
Ensembl chrNW_004936476:19,937,219...20,311,249
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Map1lc3a
microtubule associated protein 1 light chain 3 alpha
treatment
ISO
RGD
PMID:30144448
RGD:407571674
NCBI chrNW_004936561:6,104,748...6,106,348
Ensembl chrNW_004936561:6,104,742...6,106,699
G
Ndufb5
NADH:ubiquinone oxidoreductase subunit B5
ameliorates
ISO
associated with obesity
RGD
PMID:35257523
RGD:401794445
NCBI chrNW_004936566:3,537,983...3,547,807
Ensembl chrNW_004936566:3,537,609...3,547,769
G
Plcg1
phospholipase C gamma 1
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004936561:598,372...631,575
Ensembl chrNW_004936561:598,382...631,581
G
Ppbp
pro-platelet basic protein
treatment
ISO
RGD
PMID:29407168
RGD:329901925
NCBI chrNW_004936598:1,719,501...1,720,890
Ensembl chrNW_004936598:1,719,480...1,720,911
G
Pten
phosphatase and tensin homolog
ameliorates
ISO
mRNA:decreased expression:heart left ventricle (rat) RNA:increased expression:serum
RGD
PMID:26973267 PMID:29990866 PMID:32595526
RGD:11526378 RGD:155882565 RGD:401851053
NCBI chrNW_004936735:1,252,414...1,338,318
Ensembl chrNW_004936735:1,252,414...1,338,323
G
Rhoa
ras homolog family member A
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004936529:1,000,050...1,045,655
Ensembl chrNW_004936529:999,935...1,045,681
G
Rit2
Ras like without CAAX 2
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004936517:3,145,761...3,535,014
Ensembl chrNW_004936517:3,145,598...3,480,781
G
Sdhb
succinate dehydrogenase complex iron sulfur subunit B
ameliorates
ISO
associated with obesity
RGD
PMID:35257523
RGD:401794445
NCBI chrNW_004936474:3,993,224...4,021,359
Ensembl chrNW_004936474:3,990,778...4,021,423
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Serping1
serpin family G member 1
ISO
mRNA:increased expression:heart
RGD
PMID:26476955
RGD:11552746
NCBI chrNW_004936581:4,911,403...4,924,484
Ensembl chrNW_004936581:4,908,458...4,924,645
G
Sqstm1
sequestosome 1
treatment
ISO
RGD
PMID:30144448
RGD:407571674
NCBI chrNW_004936739:943,080...955,296
Ensembl chrNW_004936739:938,745...955,263
G
Tbx1
T-box transcription factor 1
treatment
ISO
RGD
PMID:27422448
RGD:155882497
NCBI chrNW_004936619:3,662,567...3,670,470
Ensembl chrNW_004936619:3,664,468...3,670,525
G
Tnf
tumor necrosis factor
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
G
Zeb1
zinc finger E-box binding homeobox 1
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004936574:17,643...175,762
Ensembl chrNW_004936574:17,684...178,293
G
Adrb1
adrenoceptor beta 1
ISO
RGD
PMID:11527135
RGD:5129114
NCBI chrNW_004936486:4,400,467...4,401,588
Ensembl chrNW_004936486:4,399,915...4,403,149
G
Adrb2
adrenoceptor beta 2
ISO
RGD
PMID:11527135
RGD:5129114
NCBI chrNW_004936504:5,985,407...5,987,453
Ensembl chrNW_004936504:5,985,960...5,987,210
G
Cpb2
carboxypeptidase B2
ISO
RGD
PMID:12624641
RGD:1598479
NCBI chrNW_004936857:577,067...609,855
Ensembl chrNW_004936857:577,585...626,267
G
Plau
plasminogen activator, urokinase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:1730212
NCBI chrNW_004936521:5,238,128...5,243,829
Ensembl chrNW_004936521:5,238,093...5,243,877
G
Ppbp
pro-platelet basic protein
ISO
protein:increased expression:plasma
RGD
PMID:17045893
RGD:401794448
NCBI chrNW_004936598:1,719,501...1,720,890
Ensembl chrNW_004936598:1,719,480...1,720,911
G
Spp1
secreted phosphoprotein 1
ISO
RGD
PMID:16421174
RGD:1581390
NCBI chrNW_004936905:148,956...156,023
Ensembl chrNW_004936905:148,945...156,079
G
Edn1
endothelin 1
ISO
protein:increased expression:aortic root, coronary sinus, plasma (human)
RGD
PMID:12581682
RGD:8661757
NCBI chrNW_004936534:885,489...892,292
Ensembl chrNW_004936534:885,287...891,772
G
Serpine1
serpin family E member 1
disease_progression
ISO
protein:decreased expression, decreased activity:heart:
RGD
PMID:12615902
RGD:13208541
NCBI chrNW_004936543:1,032,543...1,040,956
Ensembl chrNW_004936543:1,032,794...1,039,123
G
F3
coagulation factor III, tissue factor
ISO
RGD
PMID:9916935
RGD:11341701
NCBI chrNW_004936537:4,637,028...4,647,915
Ensembl chrNW_004936537:4,636,667...4,647,916
G
Hnrnpk
heterogeneous nuclear ribonucleoprotein K
ISO
RGD
PMID:21489814
RGD:155260371
NCBI chrNW_004936828:827,660...839,088
Ensembl chrNW_004936828:828,837...838,720
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Pdgfd
platelet derived growth factor D
ISO
RGD
PMID:19213942
RGD:9854642
NCBI chrNW_004936551:3,974,140...4,197,852
Ensembl chrNW_004936551:3,974,104...4,198,927
G
Epo
erythropoietin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19337937
NCBI chrNW_004936543:742,722...745,332
Ensembl chrNW_004936543:743,537...745,343
G
Plat
plasminogen activator, tissue type
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:1430592
NCBI chrNW_004936785:476,200...503,371
Ensembl chrNW_004936785:476,078...503,321
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Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21062213
NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781
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Adipoq
adiponectin, C1Q and collagen domain containing
ISO
associated with Mucocutaneous Lymph Node Syndrome;protein:increased expression:serum
RGD
PMID:22683371
RGD:8694456
NCBI chrNW_004936578:3,168,599...3,179,369
Ensembl chrNW_004936578:3,168,331...3,171,928
G
Gja1
gap junction protein alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15548583
NCBI chrNW_004936658:3,920,043...3,932,987
Ensembl chrNW_004936658:3,920,043...3,932,987
G
Itpkc
inositol-trisphosphate 3-kinase C
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18084290
NCBI chrNW_004936661:3,006,506...3,023,355
Ensembl chrNW_004936661:3,006,505...3,022,823
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Mmp12
matrix metallopeptidase 12
susceptibility
ISO
RGD
PMID:12103254
RGD:1582363
NCBI chrNW_004936551:5,107,567...5,117,843
Ensembl chrNW_004936551:5,106,285...5,117,843
G
Abca1
ATP binding cassette subfamily A member 1
ISO
RGD
PMID:11086027
RGD:1600951
NCBI chrNW_004936559:7,177,887...7,312,660
Ensembl chrNW_004936559:7,177,904...7,312,741
G
Abcc6
ATP binding cassette subfamily C member 6
ISO
DNA:nonsense mutation:exon:p.R1141X (3421C>T) (human)
RGD
PMID:12176944
RGD:11038788
NCBI chrNW_004936501:3,469,928...3,508,577
G
Abcg5
ATP binding cassette subfamily G member 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11099417 PMID:11138003
NCBI chrNW_004936508:8,093,804...8,117,467
Ensembl chrNW_004936508:8,093,804...8,116,877
G
Abcg8
ATP binding cassette subfamily G member 8
ISO
ClinVar Annotator: match by term: Premature coronary artery atherosclerosis
ClinVar
PMID:25741868
NCBI chrNW_004936508:8,074,697...8,093,424
Ensembl chrNW_004936508:8,074,674...8,093,550
G
Abo
ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004936570:1,315,192...1,322,719
G
Acat2
acetyl-CoA acetyltransferase 2
susceptibility
ISO
DNA:polymorphisms: :41A>G, 734C>T, IVS4-57_58ins48bp
RGD
PMID:16195894
RGD:1601112
NCBI chrNW_004936489:11,255,871...11,273,848
Ensembl chrNW_004936489:11,255,871...11,283,216
G
Acp1
acid phosphatase 1
ISO
RGD
PMID:19246900
RGD:2313179
NCBI chrNW_004936532:130,799...145,285
Ensembl chrNW_004936532:132,350...145,285
G
Adamts7
ADAM metallopeptidase with thrombospondin type 1 motif 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004936471:36,978,555...37,025,733
Ensembl chrNW_004936471:36,978,667...37,025,773
G
Adipoq
adiponectin, C1Q and collagen domain containing
susceptibility
ISO
protein:decreased expression:adipose tissue associated with type 2 diabetes mellitus; DNA:SNP: (rs2241766) +45T>G(human)
RGD
PMID:17878891 PMID:27218147
RGD:329956419 RGD:5686802
NCBI chrNW_004936578:3,168,599...3,179,369
Ensembl chrNW_004936578:3,168,331...3,171,928
G
Adrb3
adrenoceptor beta 3
no_association
ISO
DNA:missense mutation:cds:p.W64R (human) DNA:missense mutation:cds:p.W64R rs4994 (human)
RGD
PMID:9126344 PMID:11229427
RGD:1559325 RGD:5684412
NCBI chrNW_004936710:1,410,589...1,413,279
Ensembl chrNW_004936710:1,411,446...1,413,098
G
Adtrp
androgen dependent TFPI regulating protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378986
NCBI chrNW_004936534:1,332,682...1,389,242
Ensembl chrNW_004936534:1,332,625...1,389,572
G
Ager
advanced glycosylation end-product specific receptor
susceptibility
ISO
DNA:polymorphism:cds:p.G82S (human) associated with Mucocutaneous Lymph Node Syndrome
RGD
PMID:20668462 PMID:22337222
RGD:6767569 RGD:8695960
NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147
G
Agtr1
angiotensin II receptor type 1
ISO
RGD
PMID:12975417
RGD:1566498
NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985
G
Agxt2
alanine--glyoxylate aminotransferase 2
ISO
DNA:missense mutation:cds:rs37369, rs16899974 (human)
RGD
PMID:30284143
RGD:329961317
NCBI chrNW_004936518:6,508,928...6,544,324
Ensembl chrNW_004936518:6,508,928...6,544,146
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Ahsg
alpha 2-HS glycoprotein
susceptibility
ISO
associated with Diabetes Mellitus, Type 2;DNA:SNPs
RGD
PMID:17062776
RGD:1625792
NCBI chrNW_004936578:3,332,934...3,339,903
Ensembl chrNW_004936578:3,332,934...3,339,903
G
Akt1
AKT serine/threonine kinase 1
ISO
RGD
PMID:18054314
RGD:5509083
NCBI chrNW_004936621:620,163...639,115
Ensembl chrNW_004936621:620,074...639,093
G
Alox5ap
arachidonate 5-lipoxygenase activating protein
ISO
DNA:snps:multiple (human)
RGD
PMID:19596330
RGD:2313883
NCBI chrNW_004936472:25,477,094...25,502,823
Ensembl chrNW_004936472:25,477,010...25,502,840
G
Ampd1
adenosine monophosphate deaminase 1
susceptibility
ISO
DNA:SNP:exon 2:34C>T (human) DNA:SNP:exon:34C>T (human)
RGD
PMID:11028479 PMID:24508110
RGD:329349360 RGD:329412480
NCBI chrNW_004936627:33,350...57,231
Ensembl chrNW_004936627:33,350...57,166
G
Angptl4
angiopoietin like 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27135400
NCBI chrNW_004936588:5,188,866...5,194,924
Ensembl chrNW_004936588:5,188,850...5,194,931
G
Anks1a
ankyrin repeat and sterile alpha motif domain containing 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004936476:24,093,838...24,200,611
Ensembl chrNW_004936476:24,092,759...24,200,612
G
Apcs
amyloid P component, serum
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12714198
NCBI chrNW_004936740:979,007...987,312
Ensembl chrNW_004936740:986,460...987,361
G
Aph1b
aph-1 homolog B, gamma-secretase subunit
ISO
DNA:SNP:CDS:p.F217L (rs1047552) (human)
RGD
PMID:18987747
RGD:13703124
NCBI chrNW_004936471:23,839,962...23,869,788
Ensembl chrNW_004936471:23,839,907...23,869,935
G
Apoa1
apolipoprotein A1
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:2128269 PMID:27135400
RGD:1601188
NCBI chrNW_004936542:2,111,055...2,112,626
Ensembl chrNW_004936542:2,111,052...2,112,854
G
Apoa2
apolipoprotein A2
ISO
protein:decreased expression:serum
RGD
PMID:17923573
RGD:2313956
NCBI chrNW_004936903:520,420...521,726
Ensembl chrNW_004936903:520,650...521,910
G
Apoa5
apolipoprotein A5
no_association
ISO
DNA:polymorphism:promoter:-1131T>C, c.56C>G (human) DNA:polymorphism:promoter:-1131T>C (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15177130 PMID:15306190 PMID:24097064
RGD:1578412 RGD:2313322
NCBI chrNW_004936542:2,069,683...2,071,344
Ensembl chrNW_004936542:2,069,683...2,071,353
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Apob
apolipoprotein B
no_association
ISO
DNA:SNP:CDS:rs1042031 (human)
RGD
PMID:1732399 PMID:9585673 PMID:28167353
RGD:1578417 RGD:1578418 RGD:329901772
NCBI chrNW_004936493:10,509,118...10,549,144
Ensembl chrNW_004936493:10,509,118...10,549,144
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Apoc3
apolipoprotein C3
ISO
CTD Direct Evidence: marker/mechanism DNA:SNP:promoter:-482C>T, in women without Diabetes Mellitus, Type 2 (MeSH:D003924)
CTD RGD
PMID:14709372 PMID:15059615 PMID:24097064
RGD:1578443 RGD:1626412
NCBI chrNW_004936542:2,106,927...2,108,412
Ensembl chrNW_004936542:2,106,318...2,108,603
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Apoe
apolipoprotein E
susceptibility
ISO
associated with Diabetes Mellitus, Non-Insulin Dependent;DNA:SNP:promoter:-219G>T (human) DNA:missense mutation:cds:p.C112R (human) DNA:snp, missense mutation:promoter, cds:g.-219G>T, p.C112R (human)
RGD
PMID:12860263 PMID:14563588 PMID:15059615 PMID:28808185
RGD:13703132 RGD:1578449 RGD:1580039 RGD:1626412
NCBI chrNW_004936706:1,512,438...1,516,805
G
Apom
apolipoprotein M
susceptibility
ISO
DNA:SNP:promoter:g.-778T>C(rs805296)(human)
RGD
PMID:17674965
RGD:2314241
NCBI chrNW_004936727:1,868,751...1,874,347
Ensembl chrNW_004936727:1,865,921...1,872,214
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Arhgap31
Rho GTPase activating protein 31
susceptibility
ISO
associated with nicotine dependence;DNA:SNP: (rs10934490) (human)
RGD
PMID:19706030
RGD:329970276
NCBI chrNW_004936536:6,261,837...6,369,318
Ensembl chrNW_004936536:6,261,910...6,365,782
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Atp2b1
ATPase plasma membrane Ca2+ transporting 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22751097
NCBI chrNW_004936507:6,525,302...6,631,003
Ensembl chrNW_004936507:6,523,199...6,630,606
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Bche
butyrylcholinesterase
susceptibility
ISO
DNA:polymorphism: :p.A539T (human)
RGD
PMID:17852836
RGD:2306777
NCBI chrNW_004936707:1,784,338...1,913,401
Ensembl chrNW_004936707:1,854,444...1,913,460
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Brinp3
BMP/retinoic acid inducible neural specific 3
ISO
DNA:SNP: :rs12732361(human), associated with male.
RGD
PMID:27461004
RGD:14398490
NCBI chrNW_004936481:711,356...1,067,856
Ensembl chrNW_004936481:713,539...1,068,237
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Btnl2
butyrophilin like 2
susceptibility
ISO
associated with Mucocutaneous Lymph Node Syndrome; DNA:SNP: :rs 2395158(human)
RGD
PMID:19882345
RGD:9685030
NCBI chrNW_004936727:567,656...587,784
Ensembl chrNW_004936727:567,656...587,784
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Carf
calcium responsive transcription factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004936726:1,958,561...2,010,972
Ensembl chrNW_004936726:1,922,060...2,010,981
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Cbs
cystathionine beta-synthase
ISO
CBS variant c.844ins68
RGD
PMID:12855221
RGD:1600626
NCBI chrNW_004936500:976,043...1,003,559
Ensembl chrNW_004936500:987,128...1,003,388
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Ccl26
C-C motif chemokine ligand 26
susceptibility
ISO
protein:decreased expression:plasma (human)
RGD
PMID:16620281
RGD:11081161
NCBI chrNW_004936543:2,414,948...2,416,922
Ensembl chrNW_004936543:2,414,850...2,416,953
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Cd14
CD14 molecule
no_association
ISO
DNA:SNP:promoter
RGD
PMID:18157711
RGD:2314154
NCBI chrNW_004936531:9,572,392...9,575,771
Ensembl chrNW_004936531:9,571,796...9,575,923
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Cd36
CD36 molecule (CD36 blood group)
ISO
ClinVar Annotator: match by term: Premature coronary artery atherosclerosis
ClinVar
PMID:25741868
NCBI chrNW_004936810:791,823...838,303
Ensembl chrNW_004936810:758,182...838,365
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Cd40lg
CD40 ligand
ISO
protein:increased expression:serum CTD Direct Evidence: marker/mechanism protein:increased expression:coronary artery, serum associated with Kidney Failure, Chronic associated with Mucocutaneous Lymph Node Syndrome;DNA:SNP: :rs4810485 (human)
RGD CTD
PMID:16368305 PMID:16494885 PMID:17635572 PMID:22645426 PMID:23819214
RGD:2314209 RGD:7248436 RGD:7248750 RGD:8547776
NCBI chrNW_004936513:10,607,617...10,620,403
Ensembl chrNW_004936513:10,607,617...10,620,403
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Cdh5
cadherin 5
ISO
RGD
PMID:14695457
RGD:1598391
NCBI chrNW_004936475:16,738,772...16,775,000
Ensembl chrNW_004936475:16,738,748...16,775,123
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Cdkn2b
cyclin dependent kinase inhibitor 2B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23104008 PMID:34961328
NCBI chrNW_004936652:3,576,975...3,582,790
Ensembl chrNW_004936652:3,538,986...3,581,159
G
Celsr2
cadherin EGF LAG seven-pass G-type receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004936704:779,528...803,860
Ensembl chrNW_004936704:778,480...803,886
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Cetp
cholesteryl ester transfer protein
ISO
ClinVar Annotator: match by term: Coronary artery disease
ClinVar
PMID:14559957 PMID:17190939 PMID:20068209 PMID:25741868 PMID:28492532
NCBI chrNW_004936475:9,115,126...9,133,071
Ensembl chrNW_004936475:9,115,120...9,133,073
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Chi3l1
chitinase 3 like 1
ISO
protein:increased secretion:serum (human)
RGD
PMID:17627189
RGD:4892665
NCBI chrNW_004936567:1,411,080...1,418,332
Ensembl chrNW_004936567:1,411,037...1,418,801
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Clcn6
chloride voltage-gated channel 6
susceptibility
ISO
DNA:SNP: :rs3737964(human)
RGD
PMID:26740945
RGD:14696742
NCBI chrNW_004936474:637,930...669,383
Ensembl chrNW_004936474:637,978...669,833
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Clu
clusterin
ISO
associated with Mucocutaneous Lymph Node Syndrome;protein:decreased expression:plasma
RGD
PMID:20711835
RGD:9068393
NCBI chrNW_004936675:499,745...513,515
Ensembl chrNW_004936675:499,199...513,836
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Cpe
carboxypeptidase E
severity
ISO
DNA:SNPs:CDS:intron 4, exon 4 (A2925G, G2855A) (human)
RGD
PMID:18080843
RGD:405650688
NCBI chrNW_004936555:531,842...641,905
Ensembl chrNW_004936555:530,307...641,905
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Crp
C-reactive protein
ISO
CTD Direct Evidence: marker/mechanism associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:serum
CTD RGD
PMID:19615354 PMID:24868163
RGD:2313344
NCBI chrNW_004936740:885,855...888,854
Ensembl chrNW_004936740:883,272...890,606
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Cubn
cubilin
susceptibility
ISO
DNA:SNP,haplotypes:intron: (rs2291521)G>A (human)
RGD
PMID:33004870
RGD:329901841
NCBI chrNW_004936520:10,140,784...10,410,082
Ensembl chrNW_004936520:10,140,784...10,409,851
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CUNH1orf167
chromosome unknown C1orf167 homolog
ISO
DNA:SNP: :rs56001051(human)
RGD
PMID:31175347
RGD:14696712
NCBI chrNW_004936474:605,492...623,355
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Cxcl12
C-X-C motif chemokine ligand 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004936617:4,224,131...4,239,080
Ensembl chrNW_004936617:4,224,131...4,238,796
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Dab2ip
DAB2 interacting protein
onset
ISO
DNA:SNP:CDS:rs7025486 (human)
RGD
PMID:30595311
RGD:401938617
NCBI chrNW_004936487:10,056,809...10,243,021
Ensembl chrNW_004936487:10,145,278...10,243,174
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Ddah1
dimethylarginine dimethylaminohydrolase 1
ISO
DNA:missense mutation:cds:rs997251 (human)
RGD
PMID:30284143
RGD:329961317
NCBI chrNW_004936608:262,653...397,753
Ensembl chrNW_004936608:262,445...397,762
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Ddah2
DDAH family member 2, ADMA-independent
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17267746
NCBI chrNW_004936727:1,803,711...1,807,441
Ensembl chrNW_004936727:1,804,455...1,807,183
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Ece1
endothelin converting enzyme 1
ISO
protein:increased expression:smooth muscle cell,macrophage
RGD
PMID:8994440 PMID:10973835
RGD:1580909 RGD:7244168
NCBI chrNW_004936474:7,034,134...7,083,005
Ensembl chrNW_004936474:7,034,134...7,083,005
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Edn1
endothelin 1
severity treatment
ISO
protein:increased expression:atherosclerotic lesions (human) associated with Hypertension;DNA:missense mutation:cds:p.L198N (human)
RGD
PMID:7968078 PMID:11927217 PMID:18923236
RGD:4144886 RGD:8661705 RGD:8662294
NCBI chrNW_004936534:885,489...892,292
Ensembl chrNW_004936534:885,287...891,772
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Eng
endoglin
severity
ISO
protein:increased expression:plasma (human)
RGD
PMID:21667051
RGD:7248776
NCBI chrNW_004936487:15,467,165...15,499,180
Ensembl chrNW_004936487:15,467,835...15,477,488
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Ephx2
epoxide hydrolase 2
ISO
RGD
PMID:14732757
RGD:1580982
NCBI chrNW_004936675:350,357...392,919
Ensembl chrNW_004936675:350,342...392,551
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Epo
erythropoietin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:25245553
NCBI chrNW_004936543:742,722...745,332
Ensembl chrNW_004936543:743,537...745,343
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Ercc2
ERCC excision repair 2, TFIIH core complex helicase subunit
susceptibility
ISO
DNA:SNP: :rs13181(human)
RGD
PMID:27566080
RGD:12880440
NCBI chrNW_004936706:1,816,561...1,829,638
Ensembl chrNW_004936706:1,816,571...1,829,692
G
Esr1
estrogen receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:9396482 PMID:16159931 PMID:20559769
RGD:1580335
NCBI chrNW_004936489:4,616,839...4,887,179
Ensembl chrNW_004936489:4,614,754...4,887,171
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Esr2
estrogen receptor 2
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16099331 PMID:20559769
RGD:1581014
NCBI chrNW_004936495:7,956,168...8,018,356
Ensembl chrNW_004936495:7,956,766...8,004,357
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F2
coagulation factor II, thrombin
treatment
ISO
RGD
PMID:14961168
RGD:10449426
NCBI chrNW_004936562:2,371,725...2,388,617
Ensembl chrNW_004936562:2,372,044...2,388,650
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F7
coagulation factor VII
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased activity:plasma (human) DNA:polymorphisms:cds:R353Q (human)
RGD
PMID:8522401 PMID:10599031 PMID:11334615
RGD:2312397 RGD:2312400 RGD:2312408
NCBI chrNW_004936472:505,751...515,375
Ensembl chrNW_004936472:505,751...514,339
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Fabp2
fatty acid binding protein 2
ISO
DNA:SNP:CDS:2445G>A, amino acid A54T, associated with Diabetes Mellitus, Type 2 (MeSH:D003924) in women
RGD
PMID:15059615
RGD:1626412
NCBI chrNW_004936869:146,567...149,929
Ensembl chrNW_004936869:146,844...149,902
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Fcgr2a
Fc fragment of IgG receptor IIa
ISO
DNA:polymorphism: :p.H131R (human)
RGD
PMID:20973705
RGD:5147917
NCBI chrNW_004937131:15,542...22,099
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Fes
FES proto-oncogene, tyrosine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004936483:16,123,938...16,135,044
Ensembl chrNW_004936483:16,123,779...16,135,044
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Fgb
fibrinogen beta chain
ISO
RGD
PMID:8565160
RGD:1580382
NCBI chrNW_004936576:1,306,076...1,313,485
Ensembl chrNW_004936576:1,306,109...1,313,386
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Fto
FTO alpha-ketoglutarate dependent dioxygenase
ISO
DNA:SNP:intron:rs9939609 (human) DNA:SNP: :rs9939609 (human)
RGD
PMID:24622111 PMID:28167353
RGD:329812039 RGD:329901772
NCBI chrNW_004936475:6,321,725...6,689,410
Ensembl chrNW_004936475:6,321,711...6,689,588
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Furin
furin, paired basic amino acid cleaving enzyme
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004936483:16,136,099...16,147,945
Ensembl chrNW_004936483:16,136,099...16,144,635
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Gck
glucokinase
susceptibility
ISO
DNA:SNP:promoter:-30G>A (human)
RGD
PMID:15173029
RGD:2301876
NCBI chrNW_004936478:19,104,477...19,118,915
Ensembl chrNW_004936478:19,105,361...19,158,733
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Gdf15
growth differentiation factor 15
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20855664
NCBI chrNW_004936596:2,854,620...2,857,018
Ensembl chrNW_004936596:2,854,841...2,857,111
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Gfod1
Gfo/Idh/MocA-like oxidoreductase domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004936552:26,918...127,259
Ensembl chrNW_004936552:32,504...127,289
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Ggcx
gamma-glutamyl carboxylase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004936712:1,696,264...1,709,087
Ensembl chrNW_004936712:1,699,750...1,709,087
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Gja4
gap junction protein alpha 4
ISO
DNA:SNP:CDS:C allele of 1019C>T, amino acid P319S in men only (p = 0.0047) in a Swiss population DNA:SNP:CDS:1019C>T, amino acid P319S, in men both with and without Diabetes Mellitus, Type 2 (MeSH:D003924)
RGD
PMID:15059615 PMID:16677656
RGD:1626412 RGD:1626615
NCBI chrNW_004936474:17,439,250...17,440,829
Ensembl chrNW_004936474:17,439,327...17,440,331
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Gnb3
G protein subunit beta 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16141801
NCBI chrNW_004936709:970,169...977,059
Ensembl chrNW_004936709:970,172...976,863
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Gp6
glycoprotein VI platelet
treatment
ISO
protein:increased expression:platelet (human)
RGD
PMID:18585516
RGD:401794134
NCBI chrNW_004936886:295,950...310,614
Ensembl chrNW_004936886:296,025...310,614
G
Gpx1
glutathione peroxidase 1
ISO
DNA:repeat:exon cardiovascular complications in type 2 diabetics; protein:reduced_activity:blood
RGD
PMID:12655278 PMID:16338763
RGD:1600677 RGD:1600708
NCBI chrNW_004936529:997,943...999,123
Ensembl chrNW_004936529:998,150...998,987
G
Gpx3
glutathione peroxidase 3
ISO
mRNA:increased expression:epicardial fat
RGD
PMID:21679057
RGD:401827169
NCBI chrNW_004936647:3,904,787...3,914,223
Ensembl chrNW_004936647:3,906,113...3,913,498
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Gsr
glutathione-disulfide reductase
ISO
cardiovascular complications in type 2 diabetics; protein:reduced_activity:blood
RGD
PMID:16338763
RGD:1600708
NCBI chrNW_004936792:531,076...579,083
Ensembl chrNW_004936792:531,756...579,166
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Gucy1a1
guanylate cyclase 1 soluble subunit alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22751097
NCBI chrNW_004936576:2,353,874...2,411,747
Ensembl chrNW_004936576:2,353,761...2,411,425
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Hectd4
HECT domain E3 ubiquitin protein ligase 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22751097
NCBI chrNW_004936668:2,390,902...2,514,653
Ensembl chrNW_004936668:2,390,405...2,514,708
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Hfe
homeostatic iron regulator
no_association
ISO
RGD
PMID:12746412
RGD:1582673
NCBI chrNW_004936671:1,940,079...1,947,574
Ensembl chrNW_004936671:1,940,101...1,947,580
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Hgf
hepatocyte growth factor
ISO
RGD
PMID:11669408
RGD:8548610
NCBI chrNW_004936734:354,798...428,356
Ensembl chrNW_004936734:356,115...428,779
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Hhipl1
HHIP like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004936604:3,426,361...3,446,103
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
ISO
RGD
PMID:12742282
RGD:5508477
NCBI chrNW_004936549:1,378,536...1,400,501
Ensembl chrNW_004936549:1,378,736...1,400,532
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Hmox1
heme oxygenase 1
susceptibility no_association
ISO
CTD Direct Evidence: marker/mechanism DNA:repeat:promoter
RGD CTD
PMID:12136229 PMID:12377749 PMID:14691581
RGD:1580454 RGD:1580470 RGD:1598401
NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311
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Hnf1a
HNF1 homeobox A
susceptibility
ISO
DNA:SNP,haplotypes:intron: (rs55783344) C>T(human) DNA:SNPs,haplotypes:multiple DNA:SNP:intron 1: (rs7310409) G>A (human)
RGD
PMID:25202455 PMID:28035729 PMID:33004870
RGD:329901832 RGD:329901837 RGD:329901841
NCBI chrNW_004936668:62,103...81,549
Ensembl chrNW_004936668:67,535...81,505
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Hs3st1
heparan sulfate-glucosamine 3-sulfotransferase 1
ISO
ClinVar Annotator: match by term: Coronary artery disease
ClinVar
PMID:15266341 PMID:15965027 PMID:16024819 PMID:16410828 PMID:17179217 PMID:17558387 PMID:17568005 PMID:19122651 PMID:19303047 PMID:19858363 PMID:21152010 PMID:22090374 PMID:28126521 More...
NCBI chrNW_004936477:15,676,151...15,706,067
Ensembl chrNW_004936477:15,676,178...15,706,067
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Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
sexual_dimorphism
ISO
associated with obesity;mRNA,protein:increased expression:multiple (human)
RGD
PMID:23009206
RGD:329901914
NCBI chrNW_004936557:3,358,809...3,403,461
Ensembl chrNW_004936557:3,357,016...3,403,714
G
Hspd1
heat shock protein family D (Hsp60) member 1
severity
ISO
RGD
PMID:11222468
RGD:1624218
NCBI chrNW_004936506:1,678,069...1,687,632
G
Ica1l
islet cell autoantigen 1 like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004936726:1,853,178...1,922,684
Ensembl chrNW_004936726:1,853,868...1,902,788
G
Il10
interleukin 10
no_association susceptibility
ISO
DNA:SNPs:promoter:-592C>A (rs1800872), -819C>T (rs1800871) (human) DNA:SNP:promoter:-1082A>G (rs1800896) (human)
RGD
PMID:16460885 PMID:29525679
RGD:14975129 RGD:1598621
NCBI chrNW_004936557:5,834,874...5,838,502
Ensembl chrNW_004936557:5,834,874...5,838,502
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Il15
interleukin 15
ISO
associated with Hypertension;protein:increased expression:serum
RGD
PMID:16109314
RGD:1626610
NCBI chrNW_004936535:6,344,348...6,358,803
Ensembl chrNW_004936535:6,344,395...6,350,197
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Il1b
interleukin 1 beta
ISO
mRNA:increased expression:peripheral blood (human)
RGD
PMID:22780915
RGD:7175093
NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165
G
Il1rl1
interleukin 1 receptor like 1
severity
ISO
DNA:polymorphisms: :-27307T>A, -27614C>A (human)
RGD
PMID:20602249
RGD:5144241
NCBI chrNW_004936713:1,020,969...1,035,012
Ensembl chrNW_004936713:1,021,044...1,035,039
G
Il6
interleukin 6
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:extracellular space (human)
RGD
PMID:19368923
RGD:2307251
NCBI chrNW_004936549:7,015,595...7,016,246
G
Irak1
interleukin 1 receptor associated kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20524934
NCBI chrNW_004936809:891,407...900,311
Ensembl chrNW_004936809:890,717...900,326
G
Irs1
insulin receptor substrate 1
ISO
CTD Direct Evidence: marker/mechanism DNA:polymorphism:exon:G972R
CTD RGD
PMID:10591678
RGD:1624974
NCBI chrNW_004936525:9,064,442...9,125,972
Ensembl chrNW_004936525:9,064,466...9,122,635
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Itga2
integrin subunit alpha 2
no_association
ISO
RGD
PMID:15227729
RGD:1582294
NCBI chrNW_004936480:14,320,292...14,417,828
Ensembl chrNW_004936480:14,320,692...14,417,786
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Jcad
junctional cadherin 5 associated
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378988
NCBI chrNW_004936613:4,047,310...4,083,235
Ensembl chrNW_004936613:4,047,265...4,083,272
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Kalrn
kalirin RhoGEF kinase
susceptibility onset severity
ISO
DNA:SNP:intron: (rs9289231) T>G (human) associated with nicotine dependence; DNA:SNPs:multiple DNA:SNP:intron: (rs9289231) (human) associated with type 2 diabetes mellitus;DNA:SNP:intron: (rs9289231) T>G (human)
RGD
PMID:19706030 PMID:25316661 PMID:27218147 PMID:30483314
RGD:11076452 RGD:329955537 RGD:329956419 RGD:329970276
NCBI chrNW_004936725:749,382...1,020,702
Ensembl chrNW_004936725:572,868...1,139,142
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Kcne2
potassium voltage-gated channel subfamily E regulatory subunit 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004936500:8,067,009...8,072,383
Ensembl chrNW_004936500:8,068,188...8,068,553
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Kcnj8
potassium inwardly rectifying channel subfamily J member 8
ISO
OMIM:300464 | OMIM:607339 | OMIM:608316 | OMIM:608318 | OMIM:608320 | OMIM:608901 | OMIM:610938 | OMIM:610947 | OMIM:611139 | OMIM:612030 | OMIM:614293 | OMIM:614466
MouseDO
NCBI chrNW_004936548:5,125,583...5,132,490
Ensembl chrNW_004936548:5,125,555...5,133,078
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Kif6
kinesin family member 6
sexual_dimorphism no_association treatment
ISO
associated with type 2 diabetes mellitus;DNA:SNP: :p.W719R (rs20455) (human) DNA:SNP: :rs20455 (human)
RGD
PMID:18222354 PMID:19371834 PMID:21458191 PMID:25629058 PMID:26443250 PMID:26997531 More...
RGD:11527801 RGD:243048446 RGD:243048447 RGD:243048449 RGD:243048451 RGD:243048454
NCBI chrNW_004936476:19,937,141...20,311,988
Ensembl chrNW_004936476:19,937,219...20,311,249
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Kl
klotho
ISO
DNA:SNP:promoter: -G395>A (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12669274 PMID:16579981 PMID:16979405
RGD:1581721 RGD:1581723
NCBI chrNW_004936472:27,604,681...27,649,613
Ensembl chrNW_004936472:27,604,517...27,650,086
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Ldlr
low density lipoprotein receptor
no_association
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:16459141 PMID:21378990 PMID:27135400
RGD:1581823
NCBI chrNW_004936659:1,259,405...1,300,545
Ensembl chrNW_004936659:1,259,369...1,302,294
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Lepr
leptin receptor
susceptibility
ISO
DNA:missense mutation:CDS:p.Q223R (human)
RGD
PMID:27257426
RGD:21079462
NCBI chrNW_004936591:5,771,371...5,846,177
Ensembl chrNW_004936591:5,774,326...5,836,444
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Lipc
lipase C, hepatic type
susceptibility no_association
ISO
250G/A DNA:SNP,haplotypes: (rs17269397)A>G (human) associated with Diabetes Mellitus, Insulin-Dependent; DNA:transition:promoter:-480C>T (human) C514T
RGD
PMID:11916946 PMID:12689525 PMID:15099346 PMID:33004870
RGD:1600663 RGD:1600664 RGD:2308839 RGD:329901841
NCBI chrNW_004936471:19,604,083...19,733,721
Ensembl chrNW_004936471:19,703,236...19,733,686
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Lipg
lipase G, endothelial type
ISO
RGD
PMID:16354105
RGD:1580865
NCBI chrNW_004936497:13,406,402...13,429,833
Ensembl chrNW_004936497:13,406,357...13,429,890
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Lmod1
leiomodin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28530674
NCBI chrNW_004936567:2,557,090...2,598,069
Ensembl chrNW_004936567:2,557,080...2,596,818
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LOC101955076
low affinity immunoglobulin gamma Fc region receptor III-A
susceptibility
ISO
DNA:SNP:exon:p.F158V (rs396991)(human)
RGD
PMID:15910853
RGD:5508464
NCBI chrNW_004937131:42,523...49,533
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LOC101963150
sterol 26-hydroxylase, mitochondrial
ISO
ClinVar Annotator: match by term: Premature coronary artery atherosclerosis
ClinVar
PMID:25741868 PMID:28492532
NCBI chrNW_004936569:1,213,700...1,250,181
Ensembl chrNW_004936569:1,213,573...1,250,589
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LOC101964209
C-C chemokine receptor type 1
ISO
RGD
PMID:12742282
RGD:5508477
NCBI chrNW_004936596:177,774...183,186
Ensembl chrNW_004936596:177,812...183,186
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LOC101967032
cytochrome b-245 light chain
ISO
RGD
PMID:14709372
RGD:1578443
NCBI chrNW_004936641:1,036,967...1,044,954
Ensembl chrNW_004936641:1,036,967...1,044,991
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LOC101968921
angiotensin-converting enzyme
susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:deletion:intron:IVS16+1464-1751del (human)
CTD RGD
PMID:12975417 PMID:14989558
RGD:1566498
NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177
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LOC101972957
vitamin D 25-hydroxylase
ISO
DNA:SNP:CDS:rs10741657 (human)
RGD
PMID:25003556
RGD:401901077
NCBI chrNW_004936528:3,881,630...3,897,613
Ensembl chrNW_004936528:3,881,087...3,900,302
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LOC101976500
haptoglobin
ISO
protein:increased expression:serum
RGD
PMID:884791
RGD:1626363
NCBI chrNW_004936475:21,841,054...21,845,821
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Lox
lysyl oxidase
ISO
RGD
PMID:12393934
RGD:1581886
NCBI chrNW_004936575:2,526,067...2,533,996
Ensembl chrNW_004936575:2,524,342...2,533,559
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Lpl
lipoprotein lipase
ISO
RGD
PMID:8641022
RGD:1580537
NCBI chrNW_004936555:4,084,099...4,108,219
Ensembl chrNW_004936555:4,084,099...4,108,365
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Lrp6
LDL receptor related protein 6
ISO
ClinVar Annotator: match by term: Coronary artery disease
ClinVar
PMID:28492532
NCBI chrNW_004936587:5,065,200...5,143,029
Ensembl chrNW_004936587:4,978,043...5,140,191
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Lrp8
LDL receptor related protein 8
onset no_association
ISO
DNA:missense mutation:cds:p.R952Q (human)
RGD
PMID:17847002 PMID:18592168
RGD:2306124 RGD:2306125
NCBI chrNW_004936522:7,740,887...7,820,488
Ensembl chrNW_004936522:7,740,887...7,816,297
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Lta
lymphotoxin alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:15266304 PMID:15973460
RGD:1580414
NCBI chrNW_004936727:1,940,081...1,941,022
Ensembl chrNW_004936727:1,940,081...1,941,022
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Lum
lumican
ISO
RGD
PMID:11890723
RGD:1582121
NCBI chrNW_004936507:7,847,761...7,855,311
Ensembl chrNW_004936507:7,846,681...7,855,455
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Map3k7
mitogen-activated protein kinase kinase kinase 7
ISO
associated with hypothyroidism;mRNA:decreased expression:venous blood (human)
RGD
PMID:32495070
RGD:155791451
NCBI chrNW_004936510:1,772,971...1,836,075
Ensembl chrNW_004936510:1,772,971...1,837,765
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Mat2a
methionine adenosyltransferase 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004936712:1,710,513...1,717,339
Ensembl chrNW_004936712:1,709,716...1,717,499
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Mlxipl
MLX interacting protein like
susceptibility
ISO
DNA:SNPs,haplotypes: (rs3812316) (human) DNA:SNP:cds: G771C, Q241H (rs381231) DNA:SNP:cds: C771G, H241Q
RGD
PMID:19571538 PMID:21726544 PMID:25179879
RGD:401794579 RGD:401794581 RGD:401794582
NCBI chrNW_004936543:2,839,105...2,856,997
Ensembl chrNW_004936543:2,839,105...2,857,002
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Mmp1
matrix metallopeptidase 1
severity
ISO
DNA:insertion, haplotype:promoter:g.-1607insG rs799750 (human)
RGD
PMID:15619398 PMID:17893005
RGD:1582527 RGD:7207049
NCBI chrNW_004936551:5,167,909...5,175,149
Ensembl chrNW_004936551:5,168,044...5,174,857
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Mmp12
matrix metallopeptidase 12
susceptibility
ISO
RGD
PMID:10807873
RGD:1582366
NCBI chrNW_004936551:5,107,567...5,117,843
Ensembl chrNW_004936551:5,106,285...5,117,843
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Mmp9
matrix metallopeptidase 9
susceptibility treatment
ISO
RGD
PMID:15191941 PMID:26261622
RGD:11344965 RGD:1582644
NCBI chrNW_004936514:7,038,240...7,045,873
Ensembl chrNW_004936514:7,037,639...7,045,793
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Mras
muscle RAS oncogene homolog
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990 PMID:35590109
NCBI chrNW_004936540:672,783...725,129
Ensembl chrNW_004936540:672,544...725,143
G
Mrps6
mitochondrial ribosomal protein S6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990 PMID:34961328
NCBI chrNW_004936500:8,250,254...8,266,725
Ensembl chrNW_004936500:8,250,248...8,267,241
G
Mthfr
methylenetetrahydrofolate reductase
no_association susceptibility
ISO
DNA:transition:cds:g.677C>T (human) DNA:SNPs: (rs1801133, rs4846049) (Human)
RGD
PMID:12387655 PMID:15648053 PMID:24315498
RGD:1580579 RGD:401850782 RGD:6893453
NCBI chrNW_004936474:623,438...637,849
Ensembl chrNW_004936474:623,291...638,193
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Mylk
myosin light chain kinase
susceptibility
ISO
associated with nicotine dependence; DNA:SNP: (rs16834817)
RGD
PMID:19706030
RGD:329970276
NCBI chrNW_004936725:1,418,930...1,594,697
Ensembl chrNW_004936725:1,424,130...1,592,840
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Nampt
nicotinamide phosphoribosyltransferase
ISO
RGD
PMID:17283255
RGD:1642340
NCBI chrNW_004936479:17,682,070...17,716,713
Ensembl chrNW_004936479:17,682,201...17,716,661
G
Nbeal1
neurobeachin like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004936726:2,045,202...2,224,477
Ensembl chrNW_004936726:2,045,191...2,224,251
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Ngf
nerve growth factor
ISO
RGD
PMID:11935372
RGD:1580935
NCBI chrNW_004936627:635,784...641,290
Ensembl chrNW_004936627:635,788...645,364
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Ngfr
nerve growth factor receptor
ISO
RGD
PMID:11935372
RGD:1580935
NCBI chrNW_004936490:12,038,500...12,057,257
Ensembl chrNW_004936490:12,035,769...12,057,263
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Nnmt
nicotinamide N-methyltransferase
severity
ISO
protein:increased expression:blood serum (human)
RGD
PMID:28174167
RGD:401793727
NCBI chrNW_004936612:333,421...351,202
Ensembl chrNW_004936612:333,421...351,202
G
Nod2
nucleotide binding oligomerization domain containing 2
ISO
DNA:polymorphisms: :p.G908R, 3020_3021insC (human)
RGD
PMID:21565239
RGD:5508725
NCBI chrNW_004936475:3,708,069...3,742,845
Ensembl chrNW_004936475:3,713,362...3,745,982
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Nos2
nitric oxide synthase 2
ISO
associated with Mucocutaneous Lymph Node Syndrome; protein:increased expression:neutrophil, monocyte
RGD
PMID:14764920
RGD:1580941
NCBI chrNW_004936538:4,052,277...4,097,051
Ensembl chrNW_004936538:4,052,448...4,097,051
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Nos3
nitric oxide synthase 3
susceptibility
ISO
DNA:snp:promoter:g.-786T>C (human) DNA:duplication:intron:IVS4?-?+27 (human) DNA:snp:cds:c.894G>T (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:8564837 PMID:10510054 PMID:14989558 PMID:16284093 PMID:17267746 PMID:19696404 PMID:19761682 More...
RGD:7421529 RGD:7771567 RGD:7771578
NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534
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Nppa
natriuretic peptide A
ISO
associated with Diabetes Mellitus, Type 2;DNA:SNP:exon: 2238T>C,rs5065 (human) DNA:snp:cds:c.2238T>C (human)
RGD
PMID:12514664 PMID:22170009
RGD:1579982 RGD:7247716
NCBI chrNW_004936474:671,362...673,610
G
Nppb
natriuretic peptide B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18022110
NCBI chrNW_004936474:683,325...684,662
Ensembl chrNW_004936474:683,325...684,665
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Nr1h3
nuclear receptor subfamily 1 group H member 3
ISO
associated with type 2 diabetes mellitus;mRNA:increased expression:peripheral blood mononuclear cell (human)
RGD
PMID:28871240
RGD:401850555
NCBI chrNW_004936562:1,937,665...1,946,680
Ensembl chrNW_004936562:1,937,667...1,946,669
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Nr3c1
nuclear receptor subfamily 3 group C member 1
ISO
DNA:missense mutation:cds:p.N363S (human)
RGD
PMID:12623935
RGD:1580790
NCBI chrNW_004936504:10,960,069...11,056,834
Ensembl chrNW_004936504:10,959,192...11,056,856
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Ogg1
8-oxoguanine DNA glycosylase
susceptibility
ISO
DNA:SNP,haplotype: :p.S326C (rs1052133) (human)
RGD
PMID:23368530
RGD:401827273
NCBI chrNW_004936602:3,411,106...3,418,826
Ensembl chrNW_004936602:3,413,282...3,418,831
G
Olr1
oxidized low density lipoprotein receptor 1
severity
ISO
DNA:missense mutation:cds:p.K167N (human) DNA:snp:3' utr:T>C (human)
RGD
PMID:12810610 PMID:15562935
RGD:1580994 RGD:1580995
NCBI chrNW_004936902:405,536...416,393
Ensembl chrNW_004936902:409,704...416,401
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Pappa
pappalysin 1
severity
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:11586954 PMID:16055491
RGD:1642327
NCBI chrNW_004936487:5,000,279...5,379,786
Ensembl chrNW_004936487:5,144,044...5,376,367
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Parl
presenilin associated rhomboid like
susceptibility
ISO
DNA:missense mutation:cds:p.L262V (human)
RGD
PMID:18758826
RGD:12902623
NCBI chrNW_004936578:5,945,765...5,992,972
Ensembl chrNW_004936578:5,945,635...5,993,143
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Pcsk9
proprotein convertase subtilisin/kexin type 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990 PMID:27135400
NCBI chrNW_004936522:6,271,339...6,300,202
Ensembl chrNW_004936522:6,272,507...6,299,917
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Pdgfd
platelet derived growth factor D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378988 PMID:34961328
NCBI chrNW_004936551:3,974,140...4,197,852
Ensembl chrNW_004936551:3,974,104...4,198,927
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Pecam1
platelet and endothelial cell adhesion molecule 1
no_association
ISO
DNA:missense mutation:cds:p.L125V (human) CTD Direct Evidence: marker/mechanism DNA:polymorphism:5' utr:g.53G>A (human) DNA:missense mutations:cds:p.N536S, p.G670R (human)
RGD CTD
PMID:10780329 PMID:11795274 PMID:12732396 PMID:28530674
RGD:1581010 RGD:2311656 RGD:6771225
NCBI chrNW_004936541:4,873,459...4,919,787
Ensembl chrNW_004936541:4,873,182...4,937,500
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Phactr1
phosphatase and actin regulator 1
susceptibility sexual_dimorphism
ISO
DNA:SNP:intron:g.12903957A>G (rs9349379) (human) DNA:SNP:exon: (rs4714955) (human) DNA:SNP:intron:g.12903725A>G (rs9349379) (human) DNA:SNPs:intron: (rs9381439, rs9349379) (human) DNA:hypermethylation, hypomethylation:promoter, exon: (human) associated with familial hypercholesterolemia;DNA:SNP:intron: (rs12526453) (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:21378990 PMID:22751097 PMID:26098115 PMID:27066539 PMID:27517945 PMID:27893421 PMID:29784573 PMID:30777881 PMID:31499127 PMID:34961328 More...
RGD:401851919 RGD:401900135 RGD:401900687 RGD:401900688 RGD:401901243 RGD:401901251
NCBI chrNW_004936534:42,354...323,735
Ensembl chrNW_004936534:42,433...536,171
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Pik3c2g
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
ISO
ClinVar Annotator: match by term: Premature coronary artery atherosclerosis
ClinVar
PMID:25741868
NCBI chrNW_004936548:7,604,272...7,923,984
Ensembl chrNW_004936548:7,604,404...7,856,872
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Pla2g7
phospholipase A2 group VII
disease_progression susceptibility
ISO
DNA:polymorphism: :p.A379V (human)
RGD
PMID:15115767 PMID:17070179
RGD:6482777 RGD:6482781
NCBI chrNW_004936476:13,609,847...13,646,174
Ensembl chrNW_004936476:13,609,374...13,649,998
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Plpp3
phospholipid phosphatase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004936522:4,992,333...5,074,295
Ensembl chrNW_004936522:4,992,322...5,074,313
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Pnpla3
patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase
ISO
associated with type 2 diabetes mellitus;DNA:SNP: :rs738409 (p.I148M) (human)
RGD
PMID:31377187
RGD:14981594
NCBI chrNW_004936718:1,620,034...1,638,315
Ensembl chrNW_004936718:1,619,948...1,638,317
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Pon1
paraoxonase 1
susceptibility
ISO
DNA:missense mutation:cds:p.Q192R (human) ClinVar Annotator: match by term: Coronary artery spasm 2, susceptibility to
RGD ClinVar
PMID:7916578 PMID:8098250 PMID:8675673 PMID:8770857 PMID:9215303 PMID:9385372 PMID:9443884 PMID:10729395 PMID:11238489 PMID:11810302 PMID:11888590 PMID:12082503 PMID:15241482 PMID:21170047 PMID:25741868 More...
RGD:1580196
NCBI chrNW_004936585:4,954,871...4,979,560
Ensembl chrNW_004936585:4,954,869...4,979,591
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Pon2
paraoxonase 2
severity
ISO
DNA:missense mutation:cds:p.C311S (human)
RGD
PMID:12454802
RGD:1580217
NCBI chrNW_004936585:4,862,378...4,894,061
Ensembl chrNW_004936585:4,862,364...4,895,323
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Ppara
peroxisome proliferator activated receptor alpha
susceptibility
ISO
DNA:snp:intron: (human)
RGD
PMID:16043164
RGD:1580228
NCBI chrNW_004936629:3,672,445...3,725,645
Ensembl chrNW_004936629:3,672,460...3,725,626
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Pparg
peroxisome proliferator activated receptor gamma
ISO
protein:decreased expression:carotid artery, macrophage, smooth muscle cell (human)
RGD
PMID:21709632
RGD:8552814
NCBI chrNW_004936602:1,230,907...1,368,588
Ensembl chrNW_004936602:1,230,907...1,304,743
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Ppp4c
protein phosphatase 4 catalytic subunit
ISO
mRNA:decreased expression:blood (human)
RGD
PMID:30015926
RGD:401901084
NCBI chrNW_004936501:12,407,968...12,416,057
Ensembl chrNW_004936501:12,407,920...12,416,108
G
Prdm16
PR/SET domain 16
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:35590109
NCBI chrNW_004936737:400,819...446,768
Ensembl chrNW_004936737:404,846...446,985
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Prkag2
protein kinase AMP-activated non-catalytic subunit gamma 2
ISO
ClinVar Annotator: match by term: Coronary artery disease
ClinVar
PMID:25741868 PMID:28492532
NCBI chrNW_004936527:6,907,723...7,168,222
Ensembl chrNW_004936527:6,909,044...7,167,600
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Procr
protein C receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28530674
NCBI chrNW_004936561:5,557,640...5,562,981
Ensembl chrNW_004936561:5,557,630...5,563,030
G
Psrc1
proline and serine rich coiled-coil 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004936704:805,864...810,035
Ensembl chrNW_004936704:805,874...810,185
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14642682
NCBI chrNW_004936481:3,821,564...3,828,086
G
Pth
parathyroid hormone
ISO
protein:increased expression:serum (human)
RGD
PMID:23460043
RGD:7242420
NCBI chrNW_004936528:5,081,569...5,084,030
Ensembl chrNW_004936528:5,083,596...5,084,030
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Ptpn1
protein tyrosine phosphatase non-receptor type 1
ISO
DNA:SNP:exon 8:g.981C>T (human)
RGD
PMID:21676396
RGD:401965429
NCBI chrNW_004936514:4,065,455...4,083,847
Ensembl chrNW_004936514:4,068,238...4,084,009
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Ptpn22
protein tyrosine phosphatase non-receptor type 22
ISO
DNA: snp: cds: rs2476601
RGD
PMID:21846984
RGD:6484553
NCBI chrNW_004936690:2,180,804...2,232,869
Ensembl chrNW_004936690:2,181,047...2,232,958
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Ptprd
protein tyrosine phosphatase receptor type D
ISO
DNA:SNP:intron: (rs10115782) (human)
RGD
PMID:22216278
RGD:401976461
NCBI chrNW_004936539:2,564,815...3,369,975
Ensembl chrNW_004936539:2,564,793...2,945,293
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Rbp4
retinol binding protein 4
susceptibility sexual_dimorphism disease_progression severity
ISO
DNA:SNP:intron: (rs7094671) (human) protein:increased expression:blood plasma (human) protein:increased expression:epicardial fat (human) protein:increased expression:blood serum (human) associated with hypothyroidism;protein:increased expression:blood serum (human)
RGD
PMID:18854400 PMID:21645024 PMID:25437889 PMID:25479076 PMID:31278889
RGD:329845573 RGD:329845584 RGD:329845843 RGD:329845849 RGD:329845882
NCBI chrNW_004936601:1,401,215...1,410,195
Ensembl chrNW_004936601:1,402,691...1,410,208
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Ryr2
ryanodine receptor 2
ISO
ClinVar Annotator: match by term: Premature coronary artery atherosclerosis
ClinVar
PMID:25741868
NCBI chrNW_004936484:15,402,488...15,825,410
Ensembl chrNW_004936484:15,403,819...15,824,441
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Sars1
seryl-tRNA synthetase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004936704:747,109...766,981
Ensembl chrNW_004936704:746,775...771,305
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Sele
selectin E
susceptibility
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:mutation: :p.S128R (human) ClinVar Annotator: match by term: Coronary artery disease
RGD ClinVar
PMID:17578587 PMID:25741868
RGD:2313596
NCBI chrNW_004936481:16,915,203...16,921,840
Ensembl chrNW_004936481:16,915,182...16,921,840
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Selp
selectin P
ISO
ClinVar Annotator: match by term: Premature coronary artery atherosclerosis
ClinVar
NCBI chrNW_004936481:17,076,660...17,112,501
Ensembl chrNW_004936481:17,076,536...17,107,963
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Serpine1
serpin family E member 1
susceptibility
ISO
DNA:insertion:promoter: (human)
RGD
PMID:9484978
RGD:1580190
NCBI chrNW_004936543:1,032,543...1,040,956
Ensembl chrNW_004936543:1,032,794...1,039,123
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Serpinf2
serpin family F member 2
ISO
RGD
PMID:9184412
RGD:1625532
NCBI chrNW_004936538:7,870,898...7,877,279
Ensembl chrNW_004936538:7,870,898...7,877,219
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Sh2b3
SH2B adaptor protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004936558:4,103,898...4,126,883
Ensembl chrNW_004936558:4,104,534...4,123,869
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Slc2a4
solute carrier family 2 member 4
ISO
mRNA:decreased expression:epicardial fat, subcutaneous adipose tissue (human)
RGD
PMID:21645024
RGD:329845584
NCBI chrNW_004936595:567,267...574,051
Ensembl chrNW_004936595:567,219...574,059
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Slc5a3
solute carrier family 5 member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004936500:8,284,631...8,296,387
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Smad3
SMAD family member 3
ISO
ClinVar Annotator: match by term: Coronary artery disease
ClinVar
PMID:25741868
NCBI chrNW_004936471:27,080,662...27,185,861
Ensembl chrNW_004936471:27,080,575...27,189,793
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Soat2
sterol O-acyltransferase 2
susceptibility
ISO
DNA:polymorphisms: :p.E41G, p.T734I, IVS4-57_-58ins48bp (human)
RGD
PMID:16195894
RGD:1601112
NCBI chrNW_004936512:10,420,847...10,430,813
Ensembl chrNW_004936512:10,420,804...10,430,881
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Sod1
superoxide dismutase 1
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent
RGD
PMID:16338763
RGD:1600708
NCBI chrNW_004936500:10,345,154...10,352,873
Ensembl chrNW_004936500:10,345,154...10,352,867
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Sort1
sortilin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990 PMID:34961328
NCBI chrNW_004936704:832,651...901,658
Ensembl chrNW_004936704:837,057...901,392
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Spp1
secreted phosphoprotein 1
ISO
In type 2 diabetic patients
RGD
PMID:21034455
RGD:6903271
NCBI chrNW_004936905:148,956...156,023
Ensembl chrNW_004936905:148,945...156,079
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Srebf1
sterol regulatory element binding transcription factor 1
disease_progression severity susceptibility
ISO
associated with type 2 diabetes mellitus; mRNA:increased expression:epicardial fat (human) mRNA:decreased expression:blood serum (human) DNA:SNP, haplotype:: -36delG (human)
RGD
PMID:12752570 PMID:28367087 PMID:31610782
RGD:401827912 RGD:401842364 RGD:401842368
NCBI chrNW_004936741:1,408,669...1,419,717
Ensembl chrNW_004936741:1,406,521...1,419,776
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Srebf2
sterol regulatory element binding transcription factor 2
disease_progression
ISO
associated with type 2 diabetes mellitus;mRNA:increased expression:epicardial fat (human)
RGD
PMID:28367087
RGD:401842368
NCBI chrNW_004936492:115,923...174,614
Ensembl chrNW_004936492:115,821...174,775
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Tbx2
T-box transcription factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:35590109
NCBI chrNW_004936490:2,769,264...2,778,342
Ensembl chrNW_004936490:2,769,231...2,805,238
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Tcf21
transcription factor 21
susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:SNP: (rs12190287) (human)
CTD RGD
PMID:21378990 PMID:22751097 PMID:26909569
RGD:329337364
NCBI chrNW_004936560:1,733,903...1,736,895
Ensembl chrNW_004936560:1,733,903...1,736,890
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Tek
TEK receptor tyrosine kinase
ISO
protein:increased expression:plasma
RGD
PMID:12814387
RGD:1601489
NCBI chrNW_004936611:2,420,176...2,531,726
Ensembl chrNW_004936611:2,420,172...2,531,722
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Tert
telomerase reverse transcriptase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16890917
NCBI chrNW_004936815:468,987...492,666
Ensembl chrNW_004936815:469,020...491,697
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Thbd
thrombomodulin
severity
ISO
RGD
PMID:17012137
RGD:1601638
NCBI chrNW_004936620:2,563,900...2,568,117
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Tll1
tolloid like 1
severity
ISO
associated with type 2 diabetes:DNA:SNP:CDS:rs1503298 (human)
RGD
PMID:21911782
RGD:155883159
NCBI chrNW_004936555:7...198,382
Ensembl chrNW_004936555:193...96,729
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Tlr4
toll like receptor 4
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15632890 PMID:20524934
RGD:1580736
NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095
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Tnf
tumor necrosis factor
ISO
DNA:SNP:promoter:-863C>A, in men without Diabetes Mellitus, Type 2 (MeSH:D003924)
RGD
PMID:15059615
RGD:1626412
NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
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Tnfrsf11b
TNF receptor superfamily member 11b
ISO
protein:increased expression:serum
RGD
PMID:15926884
RGD:1620893
NCBI chrNW_004936470:27,571,263...27,598,725
Ensembl chrNW_004936470:27,571,270...27,599,089
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Tnfrsf1a
TNF receptor superfamily member 1A
severity
ISO
RGD
PMID:19845893
RGD:5131425
NCBI chrNW_004936709:1,407,327...1,421,448
Ensembl chrNW_004936709:1,407,278...1,421,921
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Tnni3
troponin I3, cardiac type
ISO
RGD
PMID:12221049
RGD:1580780
NCBI chrNW_004936886:437,754...440,925
Ensembl chrNW_004936886:437,754...440,458
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Tp53
tumor protein p53
ISO
DNA:misssense mutation: :p.R72P (rs1042522) (human)
RGD
PMID:29482350
RGD:14995930
NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425
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Traf6
TNF receptor associated factor 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20524934
NCBI chrNW_004936533:1,857,685...1,874,973
Ensembl chrNW_004936533:1,857,666...1,876,120
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Trib1
tribbles pseudokinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24097064
NCBI chrNW_004936470:22,401,713...22,408,808
Ensembl chrNW_004936470:22,401,379...22,409,490
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Ttn
titin
ISO
RGD
PMID:12221049
RGD:1580780
NCBI chrNW_004936509:7,733,426...7,999,503
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Twist1
twist family bHLH transcription factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004936546:5,331,220...5,332,669
Ensembl chrNW_004936546:5,331,863...5,332,555
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Vamp5
vesicle associated membrane protein 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004936712:1,679,276...1,686,157
Ensembl chrNW_004936712:1,679,232...1,686,268
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Vamp8
vesicle associated membrane protein 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004936712:1,688,126...1,689,742
Ensembl chrNW_004936712:1,688,093...1,689,816
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Vdr
vitamin D receptor
severity
ISO
DNA:SNP (human)
RGD
PMID:9761785
RGD:4889864
NCBI chrNW_004936512:5,741,836...5,800,999
Ensembl chrNW_004936512:5,740,748...5,801,109
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Vegfa
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD RGD
PMID:14668888 PMID:15754021 PMID:15937083
RGD:1580569
NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673
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Vim
vimentin
ISO
protein:increased expression:monocyte
RGD
PMID:21938407
RGD:6480617
NCBI chrNW_004936520:10,051,692...10,059,324
Ensembl chrNW_004936520:10,052,012...10,059,182
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Vtn
vitronectin
ISO
RGD
PMID:15678274
RGD:1580816
NCBI chrNW_004936538:4,522,275...4,525,245
Ensembl chrNW_004936538:4,522,074...4,525,336
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Wdr12
WD repeat domain 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004936726:1,931,221...1,958,457
Ensembl chrNW_004936726:1,931,183...1,958,215
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Wrn
WRN RecQ like helicase
ISO
RGD
PMID:11186893
RGD:1580824
NCBI chrNW_004936792:862,659...1,005,065
Ensembl chrNW_004936792:862,383...1,005,755
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Xrcc1
X-ray repair cross complementing 1
onset
ISO
DNA:polymorphism:: (rs1799782) (human)
RGD
PMID:24315498
RGD:401850782
NCBI chrNW_004936706:752,571...783,746
Ensembl chrNW_004936706:751,108...783,777
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Xrcc3
X-ray repair cross complementing 3
susceptibility
ISO
DNA:SNP,haplotypes:exon 7: p.T241M (rs861539) (Human)
RGD
PMID:23368530
RGD:401827273
NCBI chrNW_004936621:1,462,441...1,474,937
Ensembl chrNW_004936621:1,462,428...1,473,868
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Zc3hc1
zinc finger C3HC-type containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004936579:5,163,771...5,189,130
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Zfyve21
zinc finger FYVE-type containing 21
ISO
ClinVar Annotator: match by term: Premature coronary artery atherosclerosis
ClinVar
PMID:25741868
NCBI chrNW_004936621:1,447,459...1,462,179
Ensembl chrNW_004936621:1,446,099...1,462,219
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Mef2a
myocyte enhancer factor 2A
ISO
ClinVar Annotator: match by term: Coronary artery disease, autosomal dominant, 1 | ClinVar Annotator: match by term: Coronary artery disease/myocardial infarction
OMIM ClinVar
PMID:14645853 PMID:15496429 PMID:15841183 PMID:25741868
NCBI chrNW_004936483:3,837,891...3,982,334
Ensembl chrNW_004936483:3,834,700...3,919,766
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Cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
ISO
ClinVar Annotator: match by term: Coronary artery disease, autosomal dominant 2
ClinVar
PMID:25741868 PMID:28492532
NCBI chrNW_004936493:5,308,268...5,332,934
Ensembl chrNW_004936493:5,310,228...5,332,918
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Lrp6
LDL receptor related protein 6
ISO
ClinVar Annotator: match by term: Coronary artery disease, autosomal dominant 2
OMIM ClinVar
PMID:17332414 PMID:23703864 PMID:25741868 PMID:27713038 PMID:28492532 PMID:31589614 PMID:33118644 More...
NCBI chrNW_004936587:5,065,200...5,143,029
Ensembl chrNW_004936587:4,978,043...5,140,191
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Arhgap9
Rho GTPase activating protein 9
ISO
ClinVar Annotator: match by term: Coronary artery spasm 3, susceptibility to
ClinVar
PMID:19911011
NCBI chrNW_004936646:1,629,814...1,637,535
Ensembl chrNW_004936646:1,630,029...1,638,571
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Nos3
nitric oxide synthase 3
ISO
ClinVar Annotator: match by term: Coronary artery spasm 1, susceptibility to
ClinVar
PMID:9737779 PMID:9894802 PMID:10359729 PMID:10475066 PMID:10510054 PMID:10514107 PMID:11026457 PMID:11354626 PMID:11394896 PMID:11745998 PMID:15007011 PMID:16059745 PMID:16813604 PMID:17165044 PMID:24033266 PMID:25741868 More...
NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534
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Pon1
paraoxonase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11810302
NCBI chrNW_004936585:4,954,871...4,979,560
Ensembl chrNW_004936585:4,954,869...4,979,591
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Abca1
ATP binding cassette subfamily A member 1
ISO
ClinVar Annotator: match by term: Early-onset coronary artery disease
ClinVar
NCBI chrNW_004936559:7,177,887...7,312,660
Ensembl chrNW_004936559:7,177,904...7,312,741
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Abcg5
ATP binding cassette subfamily G member 5
ISO
ClinVar Annotator: match by term: Early-onset coronary artery disease
ClinVar
PMID:28492532
NCBI chrNW_004936508:8,093,804...8,117,467
Ensembl chrNW_004936508:8,093,804...8,116,877
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Abcg8
ATP binding cassette subfamily G member 8
ISO
ClinVar Annotator: match by term: Early-onset coronary artery disease
ClinVar
PMID:11452359 PMID:15375183 PMID:16029460 PMID:16199547 PMID:28492532
NCBI chrNW_004936508:8,074,697...8,093,424
Ensembl chrNW_004936508:8,074,674...8,093,550
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Abo
ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase
ISO
ClinVar Annotator: match by term: Three Vessel Coronary Disease
ClinVar
PMID:25741868
NCBI chrNW_004936570:1,315,192...1,322,719
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Ace2
angiotensin converting enzyme 2
susceptibility
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :8790G>A (human)
RGD
PMID:18753062
RGD:2313798
NCBI chrNW_004936470:4,964,526...5,011,808
Ensembl chrNW_004936470:4,965,332...5,011,702
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Ada
adenosine deaminase
ISO
protein:increased expression:leukocyte
RGD
PMID:17259686
RGD:1624286
NCBI chrNW_004936530:2,217,713...2,224,070
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Adamts13
ADAM metallopeptidase with thrombospondin type 1 motif 13
ISO
ClinVar Annotator: match by term: Three Vessel Coronary Disease
ClinVar
PMID:25741868 PMID:28492532
NCBI chrNW_004936669:3,449,259...3,478,471
Ensembl chrNW_004936669:3,456,494...3,478,512
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Adamts7
ADAM metallopeptidase with thrombospondin type 1 motif 7
ISO
ClinVar Annotator: match by term: Three Vessel Coronary Disease
ClinVar
PMID:25741868
NCBI chrNW_004936471:36,978,555...37,025,733
Ensembl chrNW_004936471:36,978,667...37,025,773
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Adipoq
adiponectin, C1Q and collagen domain containing
disease_progression
ISO
associated with Diabetes mellitus, Type2;
RGD
PMID:22019747 PMID:22207678
RGD:5686379 RGD:5686406
NCBI chrNW_004936578:3,168,599...3,179,369
Ensembl chrNW_004936578:3,168,331...3,171,928
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Adrb2
adrenoceptor beta 2
susceptibility
ISO
DNA:polymorphism: :p.Q27E
RGD
PMID:12682000
RGD:1601128
NCBI chrNW_004936504:5,985,407...5,987,453
Ensembl chrNW_004936504:5,985,960...5,987,210
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Adrb3
adrenoceptor beta 3
susceptibility
ISO
associated with Diabetes Mellitus, Type 2; DNA:missense mutation:cds:p.W64R rs4994(human)
RGD
PMID:10421225 PMID:20536507
RGD:1559326 RGD:5684776
NCBI chrNW_004936710:1,410,589...1,413,279
Ensembl chrNW_004936710:1,411,446...1,413,098
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Ager
advanced glycosylation end-product specific receptor
susceptibility
ISO
associated with Heart Failure; protein:increased expression:plasma (human) protein:decreased expression:plasma (human)
RGD
PMID:20685687 PMID:23396398
RGD:7243186 RGD:7244134
NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147
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Agtr1
angiotensin II receptor type 1
no_association susceptibility
ISO
DNA:polymorphism:3' utr:1166A>C (human)
RGD
PMID:9456365 PMID:9857918
RGD:1566499 RGD:1601152
NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985
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Agxt2
alanine--glyoxylate aminotransferase 2
ISO
DNA:missense mutation:cds:V140I (rs37369)(human)
RGD
PMID:24834905
RGD:329961320
NCBI chrNW_004936518:6,508,928...6,544,324
Ensembl chrNW_004936518:6,508,928...6,544,146
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Apoa4
apolipoprotein A4
susceptibility no_association
ISO
DNA:missense mutation:cds:p.T347S (human)
RGD
PMID:9013087 PMID:12676816
RGD:1578411 RGD:5685683
NCBI chrNW_004936542:2,098,683...2,101,127
Ensembl chrNW_004936542:2,098,683...2,101,127
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Apob
apolipoprotein B
ISO
ClinVar Annotator: match by term: Early-onset coronary artery disease
ClinVar
NCBI chrNW_004936493:10,509,118...10,549,144
Ensembl chrNW_004936493:10,509,118...10,549,144
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Apoc2
apolipoprotein C2
susceptibility
ISO
RGD
PMID:7590197
RGD:1601205
NCBI chrNW_004936706:1,531,219...1,531,921
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Apoc3
apolipoprotein C3
susceptibility no_association
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent ClinVar Annotator: match by term: Coronary heart disease DNA:polymorphism:promoter:-482C>T
RGD ClinVar
PMID:9536098 PMID:11060345 PMID:16321685 PMID:17576681 PMID:17654446 PMID:19074352 PMID:20097930 PMID:23701270 PMID:24941081 PMID:24941082 PMID:25225788 PMID:25741868 PMID:25962519 PMID:27114411 PMID:28406212 PMID:28492532 PMID:28825717 PMID:29237685 PMID:30255797 PMID:32041611 PMID:34548093 PMID:36325899 PMID:36876364 More...
RGD:1601224 RGD:2306754
NCBI chrNW_004936542:2,106,927...2,108,412
Ensembl chrNW_004936542:2,106,318...2,108,603
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Apoe
apolipoprotein E
onset
ISO
DNA:polymorphisms, haplotype:promoter, cds:g.-219G>T, p.C112R, p.R158C (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:10736278 PMID:11862316
RGD:1578479
NCBI chrNW_004936706:1,512,438...1,516,805
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Ccdc92
coiled-coil domain containing 92
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28869590
NCBI chrNW_004936558:956,138...983,315
Ensembl chrNW_004936558:956,109...984,392
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Cd14
CD14 molecule
ISO
protein:increased expression:monocyte
RGD
PMID:10831941
RGD:2314175
NCBI chrNW_004936531:9,572,392...9,575,771
Ensembl chrNW_004936531:9,571,796...9,575,923
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Cd36
CD36 molecule (CD36 blood group)
ISO
ClinVar Annotator: match by term: CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 7 | ClinVar Annotator: match by term: Coronary heart disease, susceptibility to, 7
OMIM ClinVar
PMID:25741868 PMID:28960434 PMID:33116287
NCBI chrNW_004936810:791,823...838,303
Ensembl chrNW_004936810:758,182...838,365
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Cd40lg
CD40 ligand
treatment
ISO
RGD
PMID:23819214
RGD:7248750
NCBI chrNW_004936513:10,607,617...10,620,403
Ensembl chrNW_004936513:10,607,617...10,620,403
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Cdkn2b
cyclin dependent kinase inhibitor 2B
ISO
ClinVar Annotator: match by term: Three Vessel Coronary Disease
ClinVar
PMID:25741868
NCBI chrNW_004936652:3,576,975...3,582,790
Ensembl chrNW_004936652:3,538,986...3,581,159
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Cetp
cholesteryl ester transfer protein
susceptibility
ISO
DNA:SNP: G>A (rs4783961) in younger than 55 years of age
RGD
PMID:29848931
RGD:401799677
NCBI chrNW_004936475:9,115,126...9,133,071
Ensembl chrNW_004936475:9,115,120...9,133,073
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Cx3cr1
C-X3-C motif chemokine receptor 1
ISO
ClinVar Annotator: match by term: Coronary heart disease, susceptibility to, 1
OMIM ClinVar
PMID:25741868
NCBI chrNW_004936473:28,508,726...28,535,640
Ensembl chrNW_004936473:28,510,523...28,535,627
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Dab2ip
DAB2 interacting protein
ISO
DNA:SNP:CDS:rs7025486 (human)
RGD
PMID:21444365
RGD:401938618
NCBI chrNW_004936487:10,056,809...10,243,021
Ensembl chrNW_004936487:10,145,278...10,243,174
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Dnah11
dynein axonemal heavy chain 11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19060911
NCBI chrNW_004936546:7,370,180...7,681,835
Ensembl chrNW_004936546:7,370,381...7,681,020
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Ephx2
epoxide hydrolase 2
ISO
RGD
PMID:16595607
RGD:1580981
NCBI chrNW_004936675:350,357...392,919
Ensembl chrNW_004936675:350,342...392,551
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Esr2
estrogen receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17367797
NCBI chrNW_004936495:7,956,168...8,018,356
Ensembl chrNW_004936495:7,956,766...8,004,357
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F12
coagulation factor XII
ISO
protein:decreased activity::
RGD
PMID:18021303
RGD:11041785
NCBI chrNW_004936597:1,687,511...1,694,782
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F13a1
coagulation factor XIII A chain
ISO
RGD
PMID:11391716
RGD:1581030
NCBI chrNW_004936534:6,199,066...6,360,374
Ensembl chrNW_004936534:6,199,066...6,361,476
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Flt1
fms related receptor tyrosine kinase 1
ISO
mRNA, protein:increased expression:ventricle myocardium
RGD
PMID:16139132
RGD:2313728
NCBI chrNW_004936472:23,442,946...23,617,523
Ensembl chrNW_004936472:23,440,088...23,617,041
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Fto
FTO alpha-ketoglutarate dependent dioxygenase
ISO
DNA:SNP: :rs9939609 (human)
RGD
PMID:26555680
RGD:11555922
NCBI chrNW_004936475:6,321,725...6,689,410
Ensembl chrNW_004936475:6,321,711...6,689,588
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G6pd
glucose-6-phosphate dehydrogenase
ISO
ClinVar Annotator: match by term: Early-onset coronary artery disease
ClinVar
PMID:1945893 PMID:3198117 PMID:6805883 PMID:7803800 PMID:8244337 PMID:8471773 PMID:9589612 PMID:10502785 PMID:11601226 PMID:12064920 PMID:15727905 PMID:16329560 PMID:16607506 PMID:25741868 PMID:28492532 PMID:29300386 PMID:29339739 PMID:30045279 PMID:30315739 PMID:31489982 PMID:31863082 PMID:33051526 PMID:33072997 PMID:34659341 PMID:34762759 PMID:34895177 PMID:35313968 PMID:35840819 PMID:36353116 More...
NCBI chrNW_004936809:1,269,900...1,285,853
Ensembl chrNW_004936809:1,269,914...1,285,889
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Ggt1
gamma-glutamyltransferase 1
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased activity:serum
RGD
PMID:16772340
RGD:2315604
NCBI chrNW_004936619:762,278...791,610
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Glul
glutamate-ammonia ligase
ISO
associated with type 2 diabetes mellitus;DNA:SNP: :rs10911021 (human)
RGD
PMID:23982368
RGD:401794410
NCBI chrNW_004936481:7,293,301...7,301,416
Ensembl chrNW_004936481:7,293,091...7,306,202
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Gp1ba
glycoprotein Ib platelet subunit alpha
ISO
RGD
PMID:14592833
RGD:1580433
NCBI chrNW_004936677:2,774,076...2,779,660
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Gp6
glycoprotein VI platelet
exacerbates treatment
ISO
protein:increased expression:venous blood, platelet (human) DNA:hypomethylation:promoter
RGD
PMID:17105818 PMID:20049463 PMID:31783053
RGD:401794440 RGD:401824645 RGD:401824649
NCBI chrNW_004936886:295,950...310,614
Ensembl chrNW_004936886:296,025...310,614
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
disease_progression
ISO
RGD
PMID:15809366
RGD:5508474
NCBI chrNW_004936549:1,378,536...1,400,501
Ensembl chrNW_004936549:1,378,736...1,400,532
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Hmox1
heme oxygenase 1
ISO
RGD
PMID:15869055
RGD:1598404
NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311
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Hnf1a
HNF1 homeobox A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28869590
NCBI chrNW_004936668:62,103...81,549
Ensembl chrNW_004936668:67,535...81,505
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Hspd1
heat shock protein family D (Hsp60) member 1
ISO
RGD
PMID:12059985
RGD:1624217
NCBI chrNW_004936506:1,678,069...1,687,632
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Igf1
insulin like growth factor 1
ISO
RGD
PMID:15521962
RGD:1626121
NCBI chrNW_004936492:11,709,623...11,784,028
Ensembl chrNW_004936492:11,709,222...11,778,351
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Igfals
insulin like growth factor binding protein acid labile subunit
ISO
RGD
PMID:15521962
RGD:1626121
NCBI chrNW_004936694:2,205,294...2,207,343
Ensembl chrNW_004936694:2,204,182...2,207,328
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Igfbp3
insulin like growth factor binding protein 3
ISO
RGD
PMID:15521962
RGD:1626121
NCBI chrNW_004936478:20,511,490...20,518,251
Ensembl chrNW_004936478:20,510,137...20,518,306
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Igfbp5
insulin like growth factor binding protein 5
ISO
RGD
PMID:15521962
RGD:1626121
NCBI chrNW_004936586:647,553...666,595
Ensembl chrNW_004936586:647,493...666,621
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Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
ISO
ClinVar Annotator: match by term: Early-onset coronary artery disease
ClinVar
PMID:1945893 PMID:3198117 PMID:6805883 PMID:7803800 PMID:8244337 PMID:8471773 PMID:9589612 PMID:10502785 PMID:11601226 PMID:12064920 PMID:15727905 PMID:16329560 PMID:16607506 PMID:25741868 PMID:28492532 PMID:29300386 PMID:29339739 PMID:30045279 PMID:30315739 PMID:31489982 PMID:31863082 PMID:33051526 PMID:33072997 PMID:34659341 PMID:34762759 PMID:34895177 PMID:35313968 PMID:35840819 PMID:36353116 More...
NCBI chrNW_004936809:1,280,254...1,306,964
Ensembl chrNW_004936809:1,257,654...1,301,813
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Il18
interleukin 18
ISO
ClinVar Annotator: match by term: Three Vessel Coronary Disease
ClinVar
PMID:25741868
NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189
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Il1b
interleukin 1 beta
ISO
DNA:polymorphism
RGD
PMID:15379752
RGD:1626636
NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165
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Irf8
interferon regulatory factor 8
susceptibility
ISO
DNA:SNPs:intron 4, intron 2: (rs925994,rs10514610) (human)
RGD
PMID:23661672
RGD:329902076
NCBI chrNW_004936641:2,608,109...2,622,446
Ensembl chrNW_004936641:2,608,100...2,622,409
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Irs1
insulin receptor substrate 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28869590
NCBI chrNW_004936525:9,064,442...9,125,972
Ensembl chrNW_004936525:9,064,466...9,122,635
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Itga2
integrin subunit alpha 2
no_association
ISO
RGD
PMID:9684730
RGD:1582306
NCBI chrNW_004936480:14,320,292...14,417,828
Ensembl chrNW_004936480:14,320,692...14,417,786
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Itgam
integrin subunit alpha M
exacerbates
ISO
protein:increased expression:monocyte (human)
RGD
PMID:20876457
RGD:329901842
NCBI chrNW_004936543:8,460,526...8,508,524
Ensembl chrNW_004936543:8,461,307...8,508,524
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Itgb3
integrin subunit beta 3
ISO
DNA:polymorphism:exon
RGD
PMID:10583927
RGD:5128478
NCBI chrNW_004936541:2,822,789...2,871,069
Ensembl chrNW_004936541:2,815,738...2,871,035
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Kalrn
kalirin RhoGEF kinase
ISO
ClinVar Annotator: match by term: Coronary heart disease, susceptibility to, 5
ClinVar
PMID:17357071 PMID:25741868
NCBI chrNW_004936725:749,382...1,020,702
Ensembl chrNW_004936725:572,868...1,139,142
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Kat2b
lysine acetyltransferase 2B
severity
ISO
DNA:snp:promoter:g.-2481G>C (human)
RGD
PMID:21062767
RGD:9590309
NCBI chrNW_004936473:12,341,545...12,415,637
Ensembl chrNW_004936473:12,344,343...12,417,875
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Kcnj8
potassium inwardly rectifying channel subfamily J member 8
no_association
ISO
RGD
PMID:12964027
RGD:1581699
NCBI chrNW_004936548:5,125,583...5,132,490
Ensembl chrNW_004936548:5,125,555...5,133,078
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Kdr
kinase insert domain receptor
ISO
mRNA, protein:increased expression:ventricle myocardium
RGD
PMID:16139132
RGD:2313728
NCBI chrNW_004936482:17,537,697...17,581,320
Ensembl chrNW_004936482:17,538,864...17,581,002
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Ldlr
low density lipoprotein receptor
ISO
ClinVar Annotator: match by term: Early-onset coronary artery disease
ClinVar
PMID:9712531 PMID:10422804 PMID:11810272 PMID:11845603 PMID:17765246 PMID:19318025 PMID:20506408 PMID:21382890 PMID:21642693 PMID:22390909 PMID:23375686 PMID:24033266 PMID:25487149 PMID:25647241 PMID:25741868 PMID:26467025 PMID:28161202 PMID:28492532 PMID:28895539 PMID:29353225 PMID:29396260 PMID:30293936 PMID:30312929 PMID:30637778 PMID:30971288 PMID:32719484 PMID:33418990 PMID:33454241 PMID:33740630 PMID:34037665 PMID:35339733 PMID:35568682 PMID:35910211 PMID:36105085 PMID:36499307 PMID:37409534 PMID:37589137 More...
NCBI chrNW_004936659:1,259,405...1,300,545
Ensembl chrNW_004936659:1,259,369...1,302,294
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Lepr
leptin receptor
onset
ISO
DNA:SNP: C>T (rs6656451) (human)
RGD
PMID:29848931
RGD:401799677
NCBI chrNW_004936591:5,771,371...5,846,177
Ensembl chrNW_004936591:5,774,326...5,836,444
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Lgals2
galectin 2
susceptibility
ISO
RGD
PMID:17040205
RGD:1581853
NCBI chrNW_004936492:3,463,195...3,500,431
Ensembl chrNW_004936492:3,483,572...3,488,730
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Lipc
lipase C, hepatic type
susceptibility
ISO
associated with Obesity and Diabetes; DNA:transition:promoter:-514C>T (human)
RGD
PMID:16570154
RGD:2308824
NCBI chrNW_004936471:19,604,083...19,733,721
Ensembl chrNW_004936471:19,703,236...19,733,686
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LOC101956126
heat shock 70 kDa protein 1
ISO
DNA:SNPs: : -110A>C (rs1008438), 190G>C (rs1043618) (human)
RGD
PMID:19333379
RGD:7257652
NCBI chrNW_004936727:1,732,323...1,735,128
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LOC101967032
cytochrome b-245 light chain
ISO
RGD
PMID:10488959
RGD:1580275
NCBI chrNW_004936641:1,036,967...1,044,954
Ensembl chrNW_004936641:1,036,967...1,044,991
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LOC101968921
angiotensin-converting enzyme
susceptibility
ISO
DNA:deletion:intron:IVS16+1464-1751del (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:8170965 PMID:9488209
RGD:8142364
NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177
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LOC101976500
haptoglobin
severity
ISO
RGD
PMID:16673012
RGD:1626344
NCBI chrNW_004936475:21,841,054...21,845,821
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Lpl
lipoprotein lipase
ISO
ClinVar Annotator: match by term: Coronary heart disease
ClinVar
PMID:8199176 PMID:8541837 PMID:8872057 PMID:10364086 PMID:10517255 PMID:21146168 PMID:24033266 PMID:25741868 PMID:28492532 More...
NCBI chrNW_004936555:4,084,099...4,108,219
Ensembl chrNW_004936555:4,084,099...4,108,365
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Lrp1
LDL receptor related protein 1
susceptibility
ISO
RGD
PMID:15121769
RGD:1581911
NCBI chrNW_004936646:1,326,900...1,407,236
Ensembl chrNW_004936646:1,327,374...1,406,456
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Maco1
macoilin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19060911
NCBI chrNW_004936474:10,105,870...10,155,029
Ensembl chrNW_004936474:10,105,359...10,155,133
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Mb
myoglobin
severity
ISO
RGD
PMID:15976963
RGD:1582388
NCBI chrNW_004936492:4,890,871...4,897,665
Ensembl chrNW_004936492:4,890,871...4,897,665
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Mgp
matrix Gla protein
susceptibility
ISO
RGD
PMID:16973975
RGD:1582502
NCBI chrNW_004936587:2,601,419...2,605,848
Ensembl chrNW_004936587:2,601,312...2,605,870
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Mif
macrophage migration inhibitory factor
ISO
coronary occlusion; mRNA:increased expression:myocardium
RGD
PMID:20367970
RGD:4890973
NCBI chrNW_004936619:1,207,058...1,208,010
Ensembl chrNW_004936619:1,203,746...1,208,442
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Mlxip
MLX interacting protein
susceptibility
ISO
DNA:SNP:3'utr: (rs4758685) (human)
RGD
PMID:23840567
RGD:401794443
NCBI chrNW_004936558:2,316,938...2,371,172
Ensembl chrNW_004936558:2,321,231...2,371,178
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Mlxipl
MLX interacting protein like
susceptibility
ISO
DNA:SNP: (rs35493868); in younger than 55 years of age
RGD
PMID:29848931
RGD:401799677
NCBI chrNW_004936543:2,839,105...2,856,997
Ensembl chrNW_004936543:2,839,105...2,857,002
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Mmp1
matrix metallopeptidase 1
susceptibility
ISO
DNA:insertion:promoter:g.-1607insG (human)
RGD
PMID:14499230
RGD:1582537
NCBI chrNW_004936551:5,167,909...5,175,149
Ensembl chrNW_004936551:5,168,044...5,174,857
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Mras
muscle RAS oncogene homolog
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28869590
NCBI chrNW_004936540:672,783...725,129
Ensembl chrNW_004936540:672,544...725,143
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Mthfr
methylenetetrahydrofolate reductase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16792904
NCBI chrNW_004936474:623,438...637,849
Ensembl chrNW_004936474:623,291...638,193
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Mttp
microsomal triglyceride transfer protein
susceptibility
ISO
DNA:polymorphism:promoter:-493G>T
RGD
PMID:15136504
RGD:1625487
NCBI chrNW_004936520:3,337,726...3,417,818
Ensembl chrNW_004936520:3,338,881...3,381,627
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Myh15
myosin heavy chain 15
ISO
DNA:snp:exon:EX28T>C rs3900940 (human)
RGD
PMID:18073581
RGD:2317145
NCBI chrNW_004936645:1,656,823...2,184,210
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Nr1h3
nuclear receptor subfamily 1 group H member 3
exacerbates
ISO
mRNA:decreased expression:peripheral blood mononuclear cell (human) mRNA:increased expression:peripheral blood mononuclear cell (human)
RGD
PMID:16252156 PMID:19211025
RGD:401827902 RGD:401850788
NCBI chrNW_004936562:1,937,665...1,946,680
Ensembl chrNW_004936562:1,937,667...1,946,669
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Oaz1
ornithine decarboxylase antizyme 1
susceptibility
ISO
DNA:SNP:intron:c.2222A>G (rs2074458) (human)
RGD
PMID:17761941
RGD:401851037
NCBI chrNW_004936588:1,356,769...1,361,037
Ensembl chrNW_004936588:1,356,769...1,361,037
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Pcsk9
proprotein convertase subtilisin/kexin type 9
susceptibility
ISO
DNA:missense mutation, nonsense mutations:cds:p.R46L, p.Y142X, p.C679X (human)
RGD
PMID:16554528
RGD:1581000
NCBI chrNW_004936522:6,271,339...6,300,202
Ensembl chrNW_004936522:6,272,507...6,299,917
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Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
ClinVar Annotator: match by term: Three Vessel Coronary Disease
ClinVar
PMID:8532023
NCBI chrNW_004936541:4,873,459...4,919,787
Ensembl chrNW_004936541:4,873,182...4,937,500
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Phactr1
phosphatase and actin regulator 1
no_association susceptibility
ISO
DNA:SNP:intron 3: (rs12526453) (human) associated with type 2 diabetes mellitus;DNA:SNP:intron: (rs12526453) (human)
RGD
PMID:22152955 PMID:28287809
RGD:11055500 RGD:401901081
NCBI chrNW_004936534:42,354...323,735
Ensembl chrNW_004936534:42,433...536,171
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Pla2g7
phospholipase A2 group VII
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15699277 PMID:21356620
RGD:6482780
NCBI chrNW_004936476:13,609,847...13,646,174
Ensembl chrNW_004936476:13,609,374...13,649,998
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Plau
plasminogen activator, urokinase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:1730212 PMID:9181759
NCBI chrNW_004936521:5,238,128...5,243,829
Ensembl chrNW_004936521:5,238,093...5,243,877
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Pltp
phospholipid transfer protein
susceptibility
ISO
protein:increased expression:serum (human)
RGD
PMID:14695459
RGD:1581038
NCBI chrNW_004936514:7,121,023...7,131,475
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Pon1
paraoxonase 1
no_association severity
ISO
DNA:missense mutation:cds:p.Q192R (human) ClinVar Annotator: match by term: Coronary artery disease, susceptibility to protein:decreased expression:serum
RGD ClinVar
PMID:7916578 PMID:8098250 PMID:8675673 PMID:8770857 PMID:9011577 PMID:9215303 PMID:9385372 PMID:9443884 PMID:9661650 PMID:11238489 PMID:11335891 PMID:11788650 PMID:11810302 PMID:11888590 PMID:11889198 PMID:11918623 PMID:12082503 PMID:15214960 PMID:15241482 PMID:19005291 PMID:21170047 PMID:25741868 More...
RGD:2313267 RGD:8547675
NCBI chrNW_004936585:4,954,871...4,979,560
Ensembl chrNW_004936585:4,954,869...4,979,591
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Pon2
paraoxonase 2
susceptibility
ISO
DNA:missense mutation:cds:p.C311S (human)
RGD
PMID:9443862
RGD:1580216
NCBI chrNW_004936585:4,862,378...4,894,061
Ensembl chrNW_004936585:4,862,364...4,895,323
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Ppbp
pro-platelet basic protein
ISO
associated with menopause; mRNA,protein:increased expression:peripheral blood mononuclear cell ,plasma
RGD
PMID:35734636
RGD:401794436
NCBI chrNW_004936598:1,719,501...1,720,890
Ensembl chrNW_004936598:1,719,480...1,720,911
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Rbp4
retinol binding protein 4
ISO
protein:increased expression:blood plasma (human)
RGD
PMID:23584360
RGD:329845574
NCBI chrNW_004936601:1,401,215...1,410,195
Ensembl chrNW_004936601:1,402,691...1,410,208
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Retn
resistin
ISO
protein:increased expression:blood
RGD
PMID:17175295
RGD:7207156
NCBI chrNW_004936588:4,705,295...4,706,653
Ensembl chrNW_004936588:4,705,119...4,706,656
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Rtel1
regulator of telomere elongation helicase 1
ameliorates
ISO
DNA:SNP:cds:rs6010620|rs4809324 (human)
RGD
PMID:30623606
RGD:152985693
NCBI chrNW_004936514:10,920,979...10,954,483
Ensembl chrNW_004936514:10,922,322...10,954,402
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Scarb1
scavenger receptor class B member 1
ISO
RGD
PMID:15967843
RGD:1580004
NCBI chrNW_004936558:530,828...555,098
Ensembl chrNW_004936558:530,828...552,892
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Selp
selectin P
ISO
protein:altered expression:serum
RGD
PMID:11597943
RGD:1580074
NCBI chrNW_004936481:17,076,660...17,112,501
Ensembl chrNW_004936481:17,076,536...17,107,963
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Serpinf2
serpin family F member 2
ISO
protein:increased expression:blood
RGD
PMID:15771120
RGD:1625529
NCBI chrNW_004936538:7,870,898...7,877,279
Ensembl chrNW_004936538:7,870,898...7,877,219
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Tcf7l2
transcription factor 7 like 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28869590
NCBI chrNW_004936486:3,473,877...3,660,565
Ensembl chrNW_004936486:3,473,843...3,660,576
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Tert
telomerase reverse transcriptase
ISO
ClinVar Annotator: match by term: Coronary artery disease, susceptibility to
ClinVar
PMID:16890917
NCBI chrNW_004936815:468,987...492,666
Ensembl chrNW_004936815:469,020...491,697
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Thbd
thrombomodulin
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma
RGD
PMID:17200788
RGD:2312456
NCBI chrNW_004936620:2,563,900...2,568,117
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Vegfa
vascular endothelial growth factor A
ISO
mRNA, protein:increased expression:ventricle myocardium
RGD
PMID:16139132
RGD:2313728
NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673
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Vkorc1
vitamin K epoxide reductase complex subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16549638
NCBI chrNW_004936501:13,459,400...13,461,864
Ensembl chrNW_004936501:13,459,022...13,462,174
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Vwf
von Willebrand factor
ISO
RGD
PMID:11864703
RGD:1580647
NCBI chrNW_004936709:1,578,137...1,741,877
Ensembl chrNW_004936709:1,579,096...1,741,754
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Zc3hc1
zinc finger C3HC-type containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28869590
NCBI chrNW_004936579:5,163,771...5,189,130
G
Aldh1a2
aldehyde dehydrogenase 1 family member A2
disease_progression
ISO
RGD
PMID:26315408
RGD:14367880
NCBI chrNW_004936471:19,175,997...19,263,335
Ensembl chrNW_004936471:19,175,992...19,263,335
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LOC101956126
heat shock 70 kDa protein 1
ISO
mRNA:increased expression:heart:
RGD
PMID:21439970
RGD:7257651
NCBI chrNW_004936727:1,732,323...1,735,128
G
Adipoq
adiponectin, C1Q and collagen domain containing
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12138120
NCBI chrNW_004936578:3,168,599...3,179,369
Ensembl chrNW_004936578:3,168,331...3,171,928
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Ahsp
alpha hemoglobin stabilizing protein
ISO
mRNA:decreased expression:blood (human)
RGD
PMID:35144391
RGD:329961301
NCBI chrNW_004936543:8,317,344...8,325,273
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Bche
butyrylcholinesterase
susceptibility
ISO
DNA:polymorphism: :p.A539T (human)
RGD
PMID:17275003
RGD:2306778
NCBI chrNW_004936707:1,784,338...1,913,401
Ensembl chrNW_004936707:1,854,444...1,913,460
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Cdh13
cadherin 13
ISO
protein:increased expression:artery, smooth muscle cell
RGD
PMID:12376824
RGD:2293553
NCBI chrNW_004936641:3,925,185...4,223,421
Ensembl chrNW_004936641:3,931,033...4,224,101
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Cxcl10
C-X-C motif chemokine ligand 10
ISO
protein:increased expression:plasma
RGD
PMID:14578618
RGD:1598500
NCBI chrNW_004936676:60,869...63,028
Ensembl chrNW_004936676:60,621...63,106
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Cxcr3
C-X-C motif chemokine receptor 3
ISO
RGD
PMID:14578618
RGD:1598500
NCBI chrNW_004936762:66,636...69,694
Ensembl chrNW_004936762:66,636...69,373
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Hmox1
heme oxygenase 1
susceptibility
ISO
RGD
PMID:16020495
RGD:1598402
NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311
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Itgb2
integrin subunit beta 2
ISO
RGD
PMID:11703955
RGD:1581185
NCBI chrNW_004936778:1,286,475...1,311,184
Ensembl chrNW_004936778:1,286,341...1,311,194
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LOC101968921
angiotensin-converting enzyme
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9236417
NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177
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Lox
lysyl oxidase
ISO
RGD
PMID:15218472
RGD:1581881
NCBI chrNW_004936575:2,526,067...2,533,996
Ensembl chrNW_004936575:2,524,342...2,533,559
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Mapk1
mitogen-activated protein kinase 1
ISO
RGD
PMID:15583728
RGD:1582284
NCBI chrNW_004936619:1,889,841...1,932,646
Ensembl chrNW_004936619:1,889,708...1,932,646
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Mmp7
matrix metallopeptidase 7
treatment
ISO
RGD
PMID:21139058
RGD:9685362
NCBI chrNW_004936551:5,388,456...5,395,071
Ensembl chrNW_004936551:5,388,459...5,395,071
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Mthfr
methylenetetrahydrofolate reductase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16489563
NCBI chrNW_004936474:623,438...637,849
Ensembl chrNW_004936474:623,291...638,193
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Myc
MYC proto-oncogene, bHLH transcription factor
treatment
ISO
RGD
PMID:7955204
RGD:10059621
NCBI chrNW_004936470:20,480,844...20,485,955
Ensembl chrNW_004936470:20,480,829...20,485,965
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Npy5r
neuropeptide Y receptor Y5
ISO
mRNA, protein:increased expression:carotid artery
RGD
PMID:12689918
RGD:1625501
NCBI chrNW_004936555:2,248,699...2,252,637
Ensembl chrNW_004936555:2,248,699...2,252,637
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Oaz1
ornithine decarboxylase antizyme 1
susceptibility
ISO
DNA:SNP:intron:c.2222A>G (rs2074458) (human)
RGD
PMID:17761941
RGD:401851037
NCBI chrNW_004936588:1,356,769...1,361,037
Ensembl chrNW_004936588:1,356,769...1,361,037
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Spp1
secreted phosphoprotein 1
ISO
RGD
PMID:12114325 PMID:16373617
RGD:1581358 RGD:1581366
NCBI chrNW_004936905:148,956...156,023
Ensembl chrNW_004936905:148,945...156,079
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16319143
RGD:1580322
NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
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Tp53
tumor protein p53
ISO
RGD
PMID:14740296
RGD:1580742
NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425
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Ucp3
uncoupling protein 3
susceptibility
ISO
DNA:polymorphism:promoter:-55C>T (human)
RGD
PMID:17786284
RGD:2313513
NCBI chrNW_004936498:3,082,575...3,095,739
Ensembl chrNW_004936498:3,082,575...3,095,737
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Apln
apelin
ISO
protein:decreased expression:plasma
RGD
PMID:19015606
RGD:2313942
NCBI chrNW_004936479:1,889,930...1,899,811
Ensembl chrNW_004936479:1,890,229...1,899,730
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Edn1
endothelin 1
treatment
ISO
RGD
PMID:10854676
RGD:8661796
NCBI chrNW_004936534:885,489...892,292
Ensembl chrNW_004936534:885,287...891,772
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Hrh2
histamine receptor H2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12721106
NCBI chrNW_004936609:624,446...664,049
Ensembl chrNW_004936609:622,311...664,084
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Igf1
insulin like growth factor 1
ISO
mRNA:increased expression:myocyte:
RGD
PMID:8102103
RGD:10046053
NCBI chrNW_004936492:11,709,623...11,784,028
Ensembl chrNW_004936492:11,709,222...11,778,351
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Igf1r
insulin like growth factor 1 receptor
ISO
mRNA:increased expression:myocyte:
RGD
PMID:8102103
RGD:10046053
NCBI chrNW_004936483:4,563,995...4,860,231
Ensembl chrNW_004936483:4,564,512...4,852,925
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Itgav
integrin subunit alpha V
ISO
RGD
PMID:11922905
RGD:1582454
NCBI chrNW_004936506:10,750,116...10,839,018
Ensembl chrNW_004936506:10,750,101...10,839,303
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Lmcd1
LIM and cysteine rich domains 1
ISO
protein:increased expression:coronary artery
RGD
PMID:32160773
RGD:243065232
NCBI chrNW_004936602:4,420,600...4,478,384
Ensembl chrNW_004936602:4,420,597...4,478,384
G
LOC101972165
myosin-7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12721106
NCBI chrNW_004936722:967,443...991,530
Ensembl chrNW_004936722:969,384...991,129
G
LOC101972957
vitamin D 25-hydroxylase
ISO
DNA:SNP:CDS: (Rs6486205|rs10741657|rs2060793)
RGD
PMID:34262949
RGD:401901074
NCBI chrNW_004936528:3,881,630...3,897,613
Ensembl chrNW_004936528:3,881,087...3,900,302
G
Mdk
midkine
ISO
RGD
PMID:10683378
RGD:1299187
NCBI chrNW_004936562:2,687,825...2,690,292
Ensembl chrNW_004936562:2,687,825...2,689,484
G
Nppa
natriuretic peptide A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12721106
NCBI chrNW_004936474:671,362...673,610
G
Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
DNA:missense mutations:cds:p.L125V, p.S563N (human)
RGD
PMID:10571959
RGD:1598382
NCBI chrNW_004936541:4,873,459...4,919,787
Ensembl chrNW_004936541:4,873,182...4,937,500
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Phactr1
phosphatase and actin regulator 1
susceptibility
ISO
DNA:SNP::g.13011943A>G (rs9349379) (human)
RGD
PMID:22745674
RGD:401900726
NCBI chrNW_004936534:42,354...323,735
Ensembl chrNW_004936534:42,433...536,171
G
Prkce
protein kinase C epsilon
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16782078
NCBI chrNW_004936508:6,018,374...6,495,216
Ensembl chrNW_004936508:6,017,551...6,494,427
G
Tnfrsf11b
TNF receptor superfamily member 11b
ISO
protein:increased expression:serum
RGD
PMID:15569000
RGD:1624167
NCBI chrNW_004936470:27,571,263...27,598,725
Ensembl chrNW_004936470:27,571,270...27,599,089
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Gp6
glycoprotein VI platelet
ISO
DNA:missense mutation:CDS:c.13254T>C (human)
RGD
PMID:15306180
RGD:401793750
NCBI chrNW_004936886:295,950...310,614
Ensembl chrNW_004936886:296,025...310,614
G
Itgb3
integrin subunit beta 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8598867
NCBI chrNW_004936541:2,822,789...2,871,069
Ensembl chrNW_004936541:2,815,738...2,871,035
G
Plat
plasminogen activator, tissue type
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:1452937 PMID:8172379 PMID:15301905
NCBI chrNW_004936785:476,200...503,371
Ensembl chrNW_004936785:476,078...503,321
G
Nos3
nitric oxide synthase 3
ISO
ClinVar Annotator: match by term: Hypertension resistant to conventional therapy
ClinVar
PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 PMID:11026457 PMID:11354626 PMID:11394896 PMID:11745998 PMID:15007011 PMID:16059745 PMID:16813604 PMID:17165044 PMID:24033266 PMID:25741868 More...
NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534
G
Ptprd
protein tyrosine phosphatase receptor type D
susceptibility
ISO
associated with coronary artery disease;DNA:SNP:intron: (rs324498) (human)
RGD
PMID:30237584
RGD:401976431
NCBI chrNW_004936539:2,564,815...3,369,975
Ensembl chrNW_004936539:2,564,793...2,945,293
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Agt
angiotensinogen
ISO
mRNA:increased expression:myocardium
RGD
PMID:11451295
RGD:8548894
NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261
G
Agtr1
angiotensin II receptor type 1
ISO
mRNA:increased expression:myocardium
RGD
PMID:11451295
RGD:8548894
NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985
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Akt1
AKT serine/threonine kinase 1
ISO
protein:increased serine phosphorylation:platelet
RGD
PMID:20467748
RGD:5509094
NCBI chrNW_004936621:620,163...639,115
Ensembl chrNW_004936621:620,074...639,093
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Apoa4
apolipoprotein A4
ISO
protein:decreased expression:blood plasma (human)
RGD
PMID:20367977
RGD:5685646
NCBI chrNW_004936542:2,098,683...2,101,127
Ensembl chrNW_004936542:2,098,683...2,101,127
G
Bdnf
brain derived neurotrophic factor
ISO
RGD
PMID:16186425
RGD:4891111
NCBI chrNW_004936540:5,530,081...5,582,765
Ensembl chrNW_004936540:5,529,942...5,585,014
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Crp
C-reactive protein
disease_progression
ISO
RGD
PMID:9761079
RGD:9491780
NCBI chrNW_004936740:885,855...888,854
Ensembl chrNW_004936740:883,272...890,606
G
Edn1
endothelin 1
ISO
associated with Coronary Artery Disease;protein:increased expression:coronary sinus, plasma (human)
RGD
PMID:14556009
RGD:8661755
NCBI chrNW_004936534:885,489...892,292
Ensembl chrNW_004936534:885,287...891,772
G
F7
coagulation factor VII
ISO
protein:increased expression:plasma (human)
RGD
PMID:10653827
RGD:2312399
NCBI chrNW_004936472:505,751...515,375
Ensembl chrNW_004936472:505,751...514,339
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
ISO
RGD
PMID:18333374
RGD:5508458
NCBI chrNW_004936549:1,378,536...1,400,501
Ensembl chrNW_004936549:1,378,736...1,400,532
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Itga2
integrin subunit alpha 2
susceptibility
ISO
RGD
PMID:15104219
RGD:1582303
NCBI chrNW_004936480:14,320,292...14,417,828
Ensembl chrNW_004936480:14,320,692...14,417,786
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Itgam
integrin subunit alpha M
ameliorates
ISO
protein:decreased expression:neutrophil (human)
RGD
PMID:18043994
RGD:329901840
NCBI chrNW_004936543:8,460,526...8,508,524
Ensembl chrNW_004936543:8,461,307...8,508,524
G
Itih4
inter-alpha-trypsin inhibitor heavy chain 4
ISO
RGD
PMID:10486281
RGD:1582334
NCBI chrNW_004936473:3,573,282...3,589,345
Ensembl chrNW_004936473:3,573,384...3,589,345
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LOC101964975
interleukin-8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10660968
NCBI chrNW_004936598:1,779,471...1,781,353
Ensembl chrNW_004936598:1,779,471...1,781,353
G
LOC101968921
angiotensin-converting enzyme
ISO
mRNA:increased expression:myocardium mRNA:increased expression:ventricular myocardium (human)
RGD
PMID:11451295 PMID:15131005
RGD:8142363 RGD:8548894
NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177
G
Mmp1
matrix metallopeptidase 1
ISO
RGD
PMID:14675588
RGD:1582536
NCBI chrNW_004936551:5,167,909...5,175,149
Ensembl chrNW_004936551:5,168,044...5,174,857
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Pappa
pappalysin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11586954
NCBI chrNW_004936487:5,000,279...5,379,786
Ensembl chrNW_004936487:5,144,044...5,376,367
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Plau
plasminogen activator, urokinase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:2382605
NCBI chrNW_004936521:5,238,128...5,243,829
Ensembl chrNW_004936521:5,238,093...5,243,877
G
Pten
phosphatase and tensin homolog
ISO
RNA:increased expression:serum
RGD
PMID:32595526
RGD:401851053
NCBI chrNW_004936735:1,252,414...1,338,318
Ensembl chrNW_004936735:1,252,414...1,338,323
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Selp
selectin P
ISO
protein:increased expression:serum
RGD
PMID:21162967
RGD:6219003
NCBI chrNW_004936481:17,076,660...17,112,501
Ensembl chrNW_004936481:17,076,536...17,107,963
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Serpinc1
serpin family C member 1
treatment
ISO
RGD
PMID:8122184
RGD:11035255
NCBI chrNW_004936481:13,981,014...13,993,750
Ensembl chrNW_004936481:13,981,019...13,993,634
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Txn
thioredoxin
ISO
RGD
PMID:15749180
RGD:1580784
NCBI chrNW_004936559:2,811,786...2,822,528
Ensembl chrNW_004936559:2,811,782...2,822,528
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Enpp1
ectonucleotide pyrophosphatase/phosphodiesterase 1
ISO
ClinVar Annotator: match by term: Coronary sclerosis, medial, of infancy
ClinVar
PMID:9536098 PMID:15940697 PMID:17576681 PMID:25741868 PMID:28492532
NCBI chrNW_004937067:194,375...246,607
G
Bdkrb1
bradykinin receptor B1
ISO
mRNA:increased expression:blood, mononuclear cell
RGD
PMID:17852785
RGD:4890450
NCBI chrNW_004936604:551,774...567,014
G
Bdkrb2
bradykinin receptor B2
ISO
mRNA:increased expression:blood, mononuclear cell
RGD
PMID:17852785
RGD:4890450
NCBI chrNW_004936604:548,844...551,031
Ensembl chrNW_004936604:548,847...549,956
G
Mthfr
methylenetetrahydrofolate reductase
ISO
DNA:transition:cds:g.677C>T (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17491230
RGD:4891159
NCBI chrNW_004936474:623,438...637,849
Ensembl chrNW_004936474:623,291...638,193
G
Tnfrsf11b
TNF receptor superfamily member 11b
ISO
protein:decreased expression:serum
RGD
PMID:15648548
RGD:1620974
NCBI chrNW_004936470:27,571,263...27,598,725
Ensembl chrNW_004936470:27,571,270...27,599,089
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Abcc9
ATP binding cassette subfamily C member 9
ISO
ClinVar Annotator: match by term: Myocardial infarction
ClinVar
PMID:16563363 PMID:18239147 PMID:20474083 PMID:21846889 PMID:23739550 PMID:23861362 PMID:24033266 PMID:24439875 PMID:25333069 PMID:25741868 PMID:26636822 PMID:26656175 PMID:26764160 PMID:28492532 More...
NCBI chrNW_004936548:4,983,461...5,110,693
Ensembl chrNW_004936548:4,987,847...5,108,104
G
Ace2
angiotensin converting enzyme 2
treatment
ISO
mRNA:increased expression:myocardium
RGD
PMID:15671045 PMID:23959549
RGD:1558664 RGD:9685449
NCBI chrNW_004936470:4,964,526...5,011,808
Ensembl chrNW_004936470:4,965,332...5,011,702
G
Acta2
actin alpha 2, smooth muscle
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24358288
NCBI chrNW_004936735:266,918...283,858
Ensembl chrNW_004936735:266,754...284,377
G
Acvr2a
activin A receptor type 2A
ISO
mRNA:decreased expression:myocardium (mouse)
RGD
PMID:32427381
RGD:329849118
NCBI chrNW_004936469:29,195,329...29,273,237
Ensembl chrNW_004936469:29,194,908...29,273,196
G
Acvr2b
activin A receptor type 2B
ISO
mRNA:decreased expression:myocardium (mouse)
RGD
PMID:32427381
RGD:329849118
NCBI chrNW_004936473:27,816,366...27,822,555
Ensembl chrNW_004936473:27,815,399...27,822,476
G
Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif 1
ISO
RGD
PMID:15625312
RGD:9681751
NCBI chrNW_004936640:959,405...967,305
Ensembl chrNW_004936640:959,417...968,842
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Add1
adducin 1
no_association
ISO
DNA:missense mutation:cds:p.G460W (human)
RGD
PMID:16420563 PMID:17082469
RGD:5147995 RGD:5148001
NCBI chrNW_004936477:20,695,109...20,766,053
Ensembl chrNW_004936477:20,691,951...20,766,152
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Adipoq
adiponectin, C1Q and collagen domain containing
disease_progression
ISO
RGD
PMID:21326342
RGD:5686351
NCBI chrNW_004936578:3,168,599...3,179,369
Ensembl chrNW_004936578:3,168,331...3,171,928
G
Adipor1
adiponectin receptor 1
ISO
mRNA, protein:decreased expression:heart left ventricle
RGD
PMID:16415076
RGD:1625764
NCBI chrNW_004936567:1,658,405...1,674,794
Ensembl chrNW_004936567:1,658,383...1,676,199
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Adipor2
adiponectin receptor 2
ISO
mRNA, protein:decreased expression:heart left ventricle
RGD
PMID:16415076
RGD:1625764
NCBI chrNW_004936606:1,911,104...2,007,109
Ensembl chrNW_004936606:1,948,743...2,007,163
G
Adora1
adenosine A1 receptor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12160945
NCBI chrNW_004936567:1,430,128...1,508,626
Ensembl chrNW_004936567:1,429,817...1,462,532
G
Adra2b
adrenoceptor alpha 2B
ISO
RGD
PMID:12535806
RGD:1559314
NCBI chrNW_004936744:249,673...253,040
Ensembl chrNW_004936744:251,467...252,816
G
Adrb1
adrenoceptor beta 1
ISO
RGD
PMID:17143192
RGD:7241557
NCBI chrNW_004936486:4,400,467...4,401,588
Ensembl chrNW_004936486:4,399,915...4,403,149
G
Adrb2
adrenoceptor beta 2
susceptibility
ISO
mRNA:decreased expression:heart DNA:polymorphisms: :p.G16R, p.Q27E, p.T164I
RGD
PMID:12400771 PMID:15520258
RGD:1601126 RGD:8548519
NCBI chrNW_004936504:5,985,407...5,987,453
Ensembl chrNW_004936504:5,985,960...5,987,210
G
Ager
advanced glycosylation end-product specific receptor
susceptibility
ISO
mRNA:increased expression:left ventricle myocardium (rat) DNA:polymorphism:promoter:-429T>C (human)
RGD
PMID:16728681 PMID:19910580
RGD:1625333 RGD:2325647
NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147
G
Agt
angiotensinogen
susceptibility
ISO
associated with hypertension;DNA:polymorphism: :p.M235T CTD Direct Evidence: marker/mechanism associated with Coronary Artery Disease;DNA:polymorphism: :p.M235T (human)
RGD CTD
PMID:1668233 PMID:11393670 PMID:16413583 PMID:17299437 PMID:21167013
RGD:1566452 RGD:1601132 RGD:5129191
NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261
G
Agtr1
angiotensin II receptor type 1
no_association susceptibility
ISO
DNA:polymorphism:3' utr:1166A>C (human)
RGD
PMID:9652322 PMID:9857918 PMID:16061119
RGD:10047101 RGD:1566499 RGD:1601150
NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985
G
Ahsg
alpha 2-HS glycoprotein
ISO
protein:increased expression:plasma
RGD
PMID:19029462
RGD:2313810
NCBI chrNW_004936578:3,332,934...3,339,903
Ensembl chrNW_004936578:3,332,934...3,339,903
G
Aimp1
aminoacyl tRNA synthetase complex interacting multifunctional protein 1
ISO
RGD
PMID:14732363
RGD:1580021
NCBI chrNW_004936814:800,085...837,140
Ensembl chrNW_004936814:798,948...837,334
G
Ak1
adenylate kinase 1
treatment
ISO
RGD
PMID:22229508
RGD:11100025
NCBI chrNW_004936487:15,507,663...15,517,401
Ensembl chrNW_004936487:15,507,498...15,517,469
G
Akt1
AKT serine/threonine kinase 1
ISO
protein:increased serine phosphorylation:platelet protein:decreased serine phosphorylation:heart
RGD
PMID:20352476 PMID:20467748
RGD:10041035 RGD:5509094
NCBI chrNW_004936621:620,163...639,115
Ensembl chrNW_004936621:620,074...639,093
G
Aldh2
aldehyde dehydrogenase 2 family member
ISO
DNA:missense mutation: :p.E487K (human)
RGD
PMID:12452318
RGD:2311152
NCBI chrNW_004936558:4,362,693...4,387,705
Ensembl chrNW_004936558:4,362,654...4,390,414
G
Alox5ap
arachidonate 5-lipoxygenase activating protein
no_association
ISO
DNA:snps:multiple (human)
RGD
PMID:14770184 PMID:19046748
RGD:1578317 RGD:2313891
NCBI chrNW_004936472:25,477,094...25,502,823
Ensembl chrNW_004936472:25,477,010...25,502,840
G
Ang
angiogenin
ISO
RGD
PMID:18462761
RGD:2325719
NCBI chrNW_004936880:39,372...40,070
G
Angpt1
angiopoietin 1
ISO
mRNA, protein:decreased expression:myocardium
RGD
PMID:15364619
RGD:1626168
NCBI chrNW_004936470:37,105,469...37,328,183
Ensembl chrNW_004936470:37,105,466...37,328,190
G
Angpt2
angiopoietin 2
ISO
protein:increased expression:left ventricular wall, heart septum (rat)
RGD
PMID:16714360
RGD:1601493
NCBI chrNW_004936615:4,472,261...4,524,537
Ensembl chrNW_004936615:4,472,247...4,524,556
G
Anxa5
annexin A5
susceptibility no_association
ISO
protein:altered localization:cardiac muscle cell, sarcolemma DNA:polymorphism: :-1C>T (human) protein:increased expression:plasma
RGD
PMID:8814351 PMID:12200370 PMID:16025836 PMID:16501019
RGD:1578384 RGD:2317541 RGD:2317542 RGD:2317543
NCBI chrNW_004936662:926,302...959,964
Ensembl chrNW_004936662:925,940...939,451
G
Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
susceptibility
ISO
DNA:polymorphism:exon 5: G>A (human)
RGD
PMID:18712175
RGD:401827276
NCBI chrNW_004936877:666,545...669,351
Ensembl chrNW_004936877:666,523...669,338
G
Apoa1
apolipoprotein A1
treatment no_association
ISO
DNA:polymorphisms
RGD
PMID:10428310 PMID:20176799 PMID:31734577
RGD:1578442 RGD:2325759 RGD:408418726
NCBI chrNW_004936542:2,111,055...2,112,626
Ensembl chrNW_004936542:2,111,052...2,112,854
G
Apoa4
apolipoprotein A4
susceptibility no_association
ISO
associated with Diabetes Mellitus, Type 2; DNA:missense mutation:cds:p.Q360H (human) DNA:mutation:intron:IVS2 (human)
RGD
PMID:7958503 PMID:10428310
RGD:1578442 RGD:5685678
NCBI chrNW_004936542:2,098,683...2,101,127
Ensembl chrNW_004936542:2,098,683...2,101,127
G
Apoc3
apolipoprotein C3
no_association
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
RGD ClinVar
PMID:10428310 PMID:25741868
RGD:1578442
NCBI chrNW_004936542:2,106,927...2,108,412
Ensembl chrNW_004936542:2,106,318...2,108,603
G
Apoe
apolipoprotein E
susceptibility
ISO
DNA:missense mutations, haplotype:cds:p.C112R, p.C158R (human) CTD Direct Evidence: marker/mechanism DNA:missense mutations, haplotypes:cds:p.C112R, p.R158C (human)
RGD CTD
PMID:10090925 PMID:10587578 PMID:17217375
RGD:10449412 RGD:1601229
NCBI chrNW_004936706:1,512,438...1,516,805
G
Apoh
apolipoprotein H
ISO
RGD
PMID:12826288 PMID:15322656
RGD:10054111 RGD:2313985
NCBI chrNW_004936541:6,683,483...6,695,094
Ensembl chrNW_004936541:6,683,534...6,695,066
G
Atg7
autophagy related 7
ISO
mRNA:increased expression:plantaris
RGD
PMID:24427319
RGD:11557988
NCBI chrNW_004936602:1,938,720...2,179,239
Ensembl chrNW_004936602:1,935,507...2,179,256
G
Atm
ATM serine/threonine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:24358288
RGD:10053570
NCBI chrNW_004936551:359,134...534,672
Ensembl chrNW_004936551:359,362...532,211
G
Atp1a1
ATPase Na+/K+ transporting subunit alpha 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29702141
NCBI chrNW_004936627:1,555,151...1,584,370
Ensembl chrNW_004936627:1,554,873...1,584,638
G
Atp5f1d
ATP synthase F1 subunit delta
treatment
ISO
protein:decreased expression:myocardium (rat)
RGD
PMID:23809007 PMID:29300489
RGD:13792656 RGD:13792681
NCBI chrNW_004936588:612,255...614,894
Ensembl chrNW_004936588:611,725...617,782
G
Atp5po
ATP synthase peripheral stalk subunit OSCP
treatment
ISO
RGD
PMID:24692845
RGD:13801194
NCBI chrNW_004936500:8,444,681...8,454,694
Ensembl chrNW_004936500:8,444,546...8,456,048
G
Avpr1a
arginine vasopressin receptor 1A
ISO
RGD
PMID:16423716
RGD:2300376
NCBI chrNW_004936545:1,788,995...1,795,842
Ensembl chrNW_004936545:1,786,571...1,794,709
G
Bak1
BCL2 antagonist/killer 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29122578
NCBI chrNW_004936476:25,347,608...25,354,772
Ensembl chrNW_004936476:25,347,545...25,355,789
G
Bax
BCL2 associated X, apoptosis regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20079142 PMID:25450231
NCBI chrNW_004936664:2,968,103...2,973,652
Ensembl chrNW_004936664:2,967,865...2,973,820
G
Bcl2
BCL2 apoptosis regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19027736
NCBI chrNW_004936497:2,209,136...2,373,580
Ensembl chrNW_004936497:2,210,334...2,210,921
G
Bcl2l1
BCL2 like 1
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17467744 PMID:20079142
RGD:1643494
NCBI chrNW_004936485:18,654,046...18,707,324
G
Bdkrb1
bradykinin receptor B1
ISO
mRNA:increased expression:heart
RGD
PMID:12489796
RGD:704379
NCBI chrNW_004936604:551,774...567,014
G
Bdkrb2
bradykinin receptor B2
ISO
mRNA:increased expression:heart
RGD
PMID:12489796
RGD:704379
NCBI chrNW_004936604:548,844...551,031
Ensembl chrNW_004936604:548,847...549,956
G
Becn1
beclin 1
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:20079142
RGD:11561913
NCBI chrNW_004936490:17,518,100...17,531,126
Ensembl chrNW_004936490:17,517,751...17,531,151
G
Birc5
baculoviral IAP repeat containing 5
ISO
RGD
PMID:15081314
RGD:2293137
NCBI chrNW_004936594:2,812,165...2,820,618
Ensembl chrNW_004936594:2,812,238...2,820,636
G
Bnip3
BCL2 interacting protein 3
ISO
mRNA:increased expression:plantaris
RGD
PMID:24427319
RGD:11557988
NCBI chrNW_004936486:18,449,371...18,460,435
Ensembl chrNW_004936486:18,448,494...18,455,927
G
Brap
BRCA1 associated protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19198608
NCBI chrNW_004936558:4,259,854...4,294,131
Ensembl chrNW_004936558:4,259,799...4,294,191
G
Brinp3
BMP/retinoic acid inducible neural specific 3
susceptibility
ISO
DNA:SNPs:3' end:
RGD
PMID:18430236
RGD:14398488
NCBI chrNW_004936481:711,356...1,067,856
Ensembl chrNW_004936481:713,539...1,068,237
G
C1qtnf6
C1q and TNF related 6
ISO
protein:decreased expression:heart
RGD
PMID:25962701
RGD:529435444
NCBI chrNW_004936492:3,759,056...3,765,345
Ensembl chrNW_004936492:3,757,939...3,765,381
G
C3
complement C3
treatment
ISO
mRNA, protein:increased expression:myocardium
RGD
PMID:16996480 PMID:31734577
RGD:1600605 RGD:408418726
NCBI chrNW_004936588:3,985,732...4,023,221
G
C7
complement C7
ISO
Protein:increased activity:serum, myocardium
RGD
PMID:15724448
RGD:1599522
NCBI chrNW_004936518:1,687,482...1,736,463
Ensembl chrNW_004936518:1,689,328...1,731,770
G
C8a
complement C8 alpha chain
ISO
RGD
PMID:7515561
RGD:1600501
NCBI chrNW_004936522:4,686,306...4,745,175
Ensembl chrNW_004936522:4,686,081...4,745,175
G
C8b
complement C8 beta chain
ISO
RGD
PMID:7515561
RGD:1600501
NCBI chrNW_004936522:4,638,111...4,673,388
Ensembl chrNW_004936522:4,644,047...4,673,615
G
Cacybp
calcyclin binding protein
ISO
mRNA:increased expression:heart
RGD
PMID:16440310
RGD:2326117
NCBI chrNW_004936481:13,198,744...13,203,518
G
Camk2d
calcium/calmodulin dependent protein kinase II delta
treatment
ISO
mRNA, protein:splice variants, increased expression:heart left ventricle (rat)
RGD
PMID:26067684
RGD:11097969
NCBI chrNW_004936563:4,226,412...4,526,139
Ensembl chrNW_004936563:4,227,986...4,526,118
G
Casp3
caspase 3
ameliorates treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:25450231 PMID:27904666 PMID:28622474
RGD:13782309 RGD:329333030
NCBI chrNW_004936554:4,571,072...4,593,765
G
Casr
calcium sensing receptor
ISO
protein:increased expression:myocardium (rat)
RGD
PMID:22527939
RGD:7205672
NCBI chrNW_004936536:8,574,064...8,599,446
Ensembl chrNW_004936536:8,574,064...8,599,454
G
Cat
catalase
ISO
CTD Direct Evidence: therapeutic
RGD CTD
PMID:14575298 PMID:21600015
RGD:1581148
NCBI chrNW_004936533:3,601,270...3,637,128
Ensembl chrNW_004936533:3,600,955...3,637,422
G
Cav3
caveolin 3
ISO
mRNA, protein; increased expression; myocardium (rat) Protein:increased expression:cytosol
RGD
PMID:12566108 PMID:29438664
RGD:126925221 RGD:1599542
NCBI chrNW_004936602:4,264,896...4,278,160
Ensembl chrNW_004936602:4,264,889...4,278,161
G
Ccl5
C-C motif chemokine ligand 5
ISO
mRNA:increased expression:heart (rat)
RGD
PMID:18954648
RGD:4890013
NCBI chrNW_004936490:253,279...259,947
Ensembl chrNW_004936490:253,034...259,965
G
Ccn1
cellular communication network factor 1
ISO
mRNA,protein:increased expression:myocardium (mouse)
RGD
PMID:15117851
RGD:329845570
NCBI chrNW_004936608:152,174...155,123
Ensembl chrNW_004936608:151,838...155,358
G
Ccn2
cellular communication network factor 2
treatment
ISO
mRNA:increased expression:left ventricle (rat)
RGD
PMID:18167060 PMID:29849775
RGD:2314623 RGD:35673318
NCBI chrNW_004936560:42,561...45,748
Ensembl chrNW_004936560:42,537...45,807
G
Ccna2
cyclin A2
ISO
protein:increased expression:cardiomyocyte:
RGD
PMID:23634243
RGD:10054471
NCBI chrNW_004936662:1,073,460...1,079,136
Ensembl chrNW_004936662:1,073,920...1,079,136
G
Ccr3
C-C motif chemokine receptor 3
ISO
RGD
PMID:18954648
RGD:4890013
NCBI chrNW_004936596:223,660...224,739
Ensembl chrNW_004936596:223,660...224,739
G
Cct7
chaperonin containing TCP1 subunit 7
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to, 1
ClinVar
PMID:24213632
NCBI chrNW_004936491:17,017,687...17,033,526
Ensembl chrNW_004936491:17,017,687...17,033,855
G
Cd14
CD14 molecule
no_association
ISO
associated with Coronary Artery Disease;DNA:SNP:promoter
RGD
PMID:10195920 PMID:14587643 PMID:17436151
RGD:1580252 RGD:1580255 RGD:2314155
NCBI chrNW_004936531:9,572,392...9,575,771
Ensembl chrNW_004936531:9,571,796...9,575,923
G
Cd36
CD36 molecule (CD36 blood group)
severity
ISO
RGD
PMID:22128087
RGD:6893560
NCBI chrNW_004936810:791,823...838,303
Ensembl chrNW_004936810:758,182...838,365
G
Cd40lg
CD40 ligand
ISO
protein:increased expression:serum
RGD
PMID:17635572
RGD:2314209
NCBI chrNW_004936513:10,607,617...10,620,403
Ensembl chrNW_004936513:10,607,617...10,620,403
G
Cd59
CD59 molecule (CD59 blood group)
ISO
protein:decreased expression:myocardium
RGD
PMID:7515561
RGD:1600501
NCBI chrNW_004936533:4,242,589...4,263,136
G
Cdkn1b
cyclin dependent kinase inhibitor 1B
treatment
ISO
RGD
PMID:22492676
RGD:10045366
NCBI chrNW_004936587:4,573,166...4,578,480
Ensembl chrNW_004936587:4,572,728...4,578,461
G
Cfl1
cofilin 1
treatment
ISO
RGD
PMID:24292258
RGD:11570534
NCBI chrNW_004936599:3,678,724...3,682,314
Ensembl chrNW_004936599:3,677,804...3,682,307
G
Cftr
CF transmembrane conductance regulator
ISO
associated with Myocardial Reperfusion Injury
RGD
PMID:23221371
RGD:11566046
NCBI chrNW_004936589:1,565,933...1,719,208
G
Chi3l1
chitinase 3 like 1
ISO
protein:increased secretion:serum (human)
RGD
PMID:18480670
RGD:4892633
NCBI chrNW_004936567:1,411,080...1,418,332
Ensembl chrNW_004936567:1,411,037...1,418,801
G
Ciita
class II major histocompatibility complex transactivator
susceptibility no_association
ISO
DNA:polymorphism:promoter:-168A>G
RGD
PMID:15821736 PMID:17183695
RGD:1358146 RGD:5491201
NCBI chrNW_004936530:9,033,510...9,073,341
G
Ckb
creatine kinase B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12359538
NCBI chrNW_004936621:1,612,398...1,615,821
Ensembl chrNW_004936621:1,612,393...1,615,822
G
Ckm
creatine kinase, M-type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:3279722 PMID:12359538
NCBI chrNW_004936706:1,792,298...1,801,063
Ensembl chrNW_004936706:1,790,958...1,801,139
G
Clu
clusterin
treatment
ISO
RGD
PMID:20854280
RGD:9068409
NCBI chrNW_004936675:499,745...513,515
Ensembl chrNW_004936675:499,199...513,836
G
Col1a1
collagen type I alpha 1 chain
treatment
ISO
RGD
PMID:25636075
RGD:11041598
NCBI chrNW_004936490:11,448,552...11,465,836
Ensembl chrNW_004936490:11,448,654...11,464,444
G
Col3a1
collagen type III alpha 1 chain
treatment
ISO
RGD
PMID:25636075
RGD:11041598
NCBI chrNW_004936506:8,886,494...8,923,921
Ensembl chrNW_004936506:8,886,494...8,923,930
G
Col4a1
collagen type IV alpha 1 chain
susceptibility
ISO
DNA:polymorphism: :p.Q1334H (human)
RGD
PMID:18077766
RGD:2311341
NCBI chrNW_004936472:2,416,043...2,543,561
Ensembl chrNW_004936472:2,416,566...2,542,814
G
Col6a3
collagen type VI alpha 3 chain
ISO
DNA:SNP:CDS:E1386K (rs146092501) (human)
RGD
PMID:30226566
RGD:401851058
NCBI chrNW_004936525:905,419...983,486
Ensembl chrNW_004936525:921,725...983,377
G
Creb1
cAMP responsive element binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19027736
NCBI chrNW_004936631:3,721,307...3,785,346
Ensembl chrNW_004936631:3,721,313...3,780,892
G
Crem
cAMP responsive element modulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19027736
NCBI chrNW_004936574:3,478,969...3,546,738
Ensembl chrNW_004936574:3,479,060...3,548,951
G
Crp
C-reactive protein
ISO
protein:increased expression:serum associated with Angina, Unstable;
RGD
PMID:9761079 PMID:21046814 PMID:22446866
RGD:5131456 RGD:6482304 RGD:9491780
NCBI chrNW_004936740:885,855...888,854
Ensembl chrNW_004936740:883,272...890,606
G
Cs
citrate synthase
severity
ISO
protein:decreased expression:diaphragm, mitochondrion
RGD
PMID:1877670 PMID:34416105
RGD:243048469 RGD:243048471
NCBI chrNW_004936646:676,926...704,988
Ensembl chrNW_004936646:678,307...692,777
G
Csf2
colony stimulating factor 2
ISO
RGD
PMID:21326109
RGD:5131507
NCBI chrNW_004936647:3,081,896...3,083,864
Ensembl chrNW_004936647:3,081,896...3,083,864
G
Csf3
colony stimulating factor 3
treatment
ISO
RGD
PMID:15639484
RGD:11039417
NCBI chrNW_004936490:15,142,526...15,146,375
Ensembl chrNW_004936490:15,142,808...15,144,487
G
Csnk2a1
casein kinase 2 alpha 1
ISO
RGD
PMID:15090263
RGD:11565830
NCBI chrNW_004936485:17,966,993...18,021,191
G
Csnk2b
casein kinase 2 beta
ISO
RGD
PMID:15090263
RGD:11565830
NCBI chrNW_004936727:1,857,596...1,862,551
Ensembl chrNW_004936727:1,857,596...1,862,002
G
Ctla4
cytotoxic T-lymphocyte associated protein 4
ISO
DNA:SNP:CDS:49A>G (human)
RGD
PMID:17652883
RGD:2301976
NCBI chrNW_004936631:484,356...489,643
Ensembl chrNW_004936631:484,356...489,643
G
Cxcl12
C-X-C motif chemokine ligand 12
ISO
mRNA:increased expression:heart left ventricle
RGD
PMID:11820456 PMID:19187644
RGD:2306567 RGD:632503
NCBI chrNW_004936617:4,224,131...4,239,080
Ensembl chrNW_004936617:4,224,131...4,238,796
G
Cybb
cytochrome b-245 beta chain
ISO
mRNA:increase expression:ventricle myocardium
RGD
PMID:11243862
RGD:1599690
NCBI chrNW_004936502:4,631,750...4,676,686
Ensembl chrNW_004936502:4,635,149...4,676,904
G
Dab2
DAB adaptor protein 2
ISO
protein:increased expression:cardiomyocyte
RGD
PMID:20666606 PMID:21762377
RGD:7243156 RGD:7243158
NCBI chrNW_004936518:2,915,819...2,936,474
Ensembl chrNW_004936518:2,915,764...2,937,875
G
Dab2ip
DAB2 interacting protein
onset
ISO
CTD Direct Evidence: marker/mechanism DNA:SNP:CDS:intron 1 (rs7025486) (human)
CTD RGD
PMID:20622881
RGD:401901599
NCBI chrNW_004936487:10,056,809...10,243,021
Ensembl chrNW_004936487:10,145,278...10,243,174
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Dag1
dystroglycan 1
treatment
ISO
RGD
PMID:12034665
RGD:11541047
NCBI chrNW_004936529:1,099,510...1,171,587
Ensembl chrNW_004936529:1,099,647...1,173,124
G
Dcn
decorin
ISO
RGD
PMID:16311904
RGD:1598497
NCBI chrNW_004936507:7,887,259...7,923,055
Ensembl chrNW_004936507:7,884,654...7,922,961
G
Ddit3
DNA damage inducible transcript 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25450231
NCBI chrNW_004936646:1,665,019...1,669,212
G
Dgkz
diacylglycerol kinase zeta
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17071729
NCBI chrNW_004936562:2,690,907...2,733,455
Ensembl chrNW_004936562:2,690,858...2,733,620
G
Dvl1
dishevelled segment polarity protein 1
ISO
RGD
PMID:15256074
RGD:1580899
NCBI chrNW_004936737:1,797,348...1,811,043
Ensembl chrNW_004936737:1,797,326...1,810,286
G
Dyrk1a
dual specificity tyrosine phosphorylation regulated kinase 1A
treatment
ISO
associated with heart failure; protein:increased expression, increased activity:heart left ventricle (rat)
RGD
PMID:26067684
RGD:11097969
NCBI chrNW_004936500:5,317,109...5,423,593
Ensembl chrNW_004936500:5,316,164...5,404,353
G
Ece1
endothelin converting enzyme 1
ISO
RGD
PMID:9607404
RGD:1580912
NCBI chrNW_004936474:7,034,134...7,083,005
Ensembl chrNW_004936474:7,034,134...7,083,005
G
Edn1
endothelin 1
severity
ISO
protein:increased secretion:plasma (human) mRNA:increased expression:heart left ventricle (rat)
RGD
PMID:10573185 PMID:17893002
RGD:1580921 RGD:4144880
NCBI chrNW_004936534:885,489...892,292
Ensembl chrNW_004936534:885,287...891,772
G
Edn2
endothelin 2
ISO
RGD
PMID:10573185
RGD:1580921
NCBI chrNW_004936474:23,061,219...23,064,525
Ensembl chrNW_004936474:23,060,905...23,064,566
G
Ednra
endothelin receptor type A
ISO
RGD
PMID:12524016
RGD:1580948
NCBI chrNW_004936535:1,950,117...2,005,786
Ensembl chrNW_004936535:1,949,941...2,005,910
G
Ednrb
endothelin receptor type B
ISO
RGD
PMID:12524016
RGD:1580948
NCBI chrNW_004936511:3,446,864...3,478,434
Ensembl chrNW_004936511:3,446,839...3,478,434
G
Egln1
egl-9 family hypoxia inducible factor 1
ISO
RGD
PMID:16765982
RGD:11252084
NCBI chrNW_004936484:19,343,770...19,386,087
G
Egln3
egl-9 family hypoxia inducible factor 3
ISO
RGD
PMID:16765982
RGD:11252084
NCBI chrNW_004936494:8,240,272...8,267,487
Ensembl chrNW_004936494:8,238,858...8,267,606
G
Epas1
endothelial PAS domain protein 1
ISO
RGD
PMID:15247145 PMID:18484163
RGD:1580977 RGD:5147886
NCBI chrNW_004936508:5,855,748...5,938,879
Ensembl chrNW_004936508:5,855,732...5,938,856
G
Ephb1
EPH receptor B1
ameliorates
ISO
RGD
PMID:28622474
RGD:329333030
NCBI chrNW_004936529:8,006,780...8,261,923
Ensembl chrNW_004936529:7,839,768...8,261,942
G
Ephx2
epoxide hydrolase 2
ISO
RGD
PMID:19716829
RGD:5688358
NCBI chrNW_004936675:350,357...392,919
Ensembl chrNW_004936675:350,342...392,551
G
Epo
erythropoietin
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:19337937 PMID:21415704
RGD:10400907
NCBI chrNW_004936543:742,722...745,332
Ensembl chrNW_004936543:743,537...745,343
G
Epor
erythropoietin receptor
ISO
RGD
PMID:21415704
RGD:10400907
NCBI chrNW_004936659:1,468,391...1,473,880
Ensembl chrNW_004936659:1,468,634...1,473,880
G
Erbb2
erb-b2 receptor tyrosine kinase 2
treatment
ISO
RGD
PMID:26892146
RGD:11522702
NCBI chrNW_004936490:14,887,062...14,910,038
Ensembl chrNW_004936490:14,887,043...14,909,956
G
Erbb4
erb-b2 receptor tyrosine kinase 4
treatment
ISO
RGD
PMID:26892146
RGD:11522702
NCBI chrNW_004936586:4,065,767...5,100,690
Ensembl chrNW_004936586:4,066,498...5,100,035
G
Esr1
estrogen receptor 1
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
OMIM ClinVar
PMID:11894143 PMID:11919305 PMID:14600184 PMID:15133719 PMID:25741868
NCBI chrNW_004936489:4,616,839...4,887,179
Ensembl chrNW_004936489:4,614,754...4,887,171
G
F10
coagulation factor X
ISO
ClinVar Annotator: match by term: Myocardial infarction, decreased susceptibility to
ClinVar
PMID:10984565 PMID:12181036 PMID:25741868
NCBI chrNW_004936472:475,851...502,341
Ensembl chrNW_004936472:475,333...502,377
G
F12
coagulation factor XII
susceptibility
ISO
DNA:polymorphism:promoter:-46C>T(human)
RGD
PMID:16411408
RGD:11041803
NCBI chrNW_004936597:1,687,511...1,694,782
G
F13a1
coagulation factor XIII A chain
ISO
ClinVar Annotator: match by term: Myocardial infarction, protection against | ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
ClinVar OMIM
PMID:8025280 PMID:9459313 PMID:9550516 PMID:10365735 PMID:10910914 PMID:12072871 PMID:12456499 PMID:17393027 PMID:25741868 More...
NCBI chrNW_004936534:6,199,066...6,360,374
Ensembl chrNW_004936534:6,199,066...6,361,476
G
F2
coagulation factor II, thrombin
susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:polymorphism::20210G>A(human)
CTD RGD
PMID:9292507 PMID:9531249 PMID:10027711 PMID:12480694
RGD:1581022
NCBI chrNW_004936562:2,371,725...2,388,617
Ensembl chrNW_004936562:2,372,044...2,388,650
G
F3
coagulation factor III, tissue factor
treatment
ISO
RGD
PMID:21229253
RGD:11062083
NCBI chrNW_004936537:4,637,028...4,647,915
Ensembl chrNW_004936537:4,636,667...4,647,916
G
F5
coagulation factor V
no_association susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:mutation:cds:1691G>A (human)
CTD RGD
PMID:9531249 PMID:10590188 PMID:15131548
RGD:11564335 RGD:11564337
NCBI chrNW_004936481:17,114,441...17,178,902
Ensembl chrNW_004936481:17,114,480...17,178,844
G
F7
coagulation factor VII
susceptibility
ISO
ClinVar Annotator: match by term: F7-related condition | ClinVar Annotator: match by term: Myocardial infarction, decreased susceptibility to | ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
OMIM ClinVar
PMID:627745 PMID:1634227 PMID:2070047 PMID:6812354 PMID:7919338 PMID:7974346 PMID:7981691 PMID:8043443 PMID:8242057 PMID:8448207 PMID:8844208 PMID:8883260 PMID:9657438 PMID:9949166 PMID:10554827 PMID:10862079 PMID:10959697 PMID:10984565 PMID:11091194 PMID:11092214 PMID:11129332 PMID:11225604 PMID:11313743 PMID:11918550 PMID:11931672 PMID:12181036 PMID:12632035 PMID:12695753 PMID:12903033 PMID:12935978 PMID:14521598 PMID:15142120 PMID:15194538 PMID:15456489 PMID:15590402 PMID:15735798 PMID:15741795 PMID:15907525 PMID:16732384 PMID:16753603 PMID:16807660 PMID:18282149 PMID:18669152 PMID:18976247 PMID:19601987 PMID:19751712 PMID:19780835 PMID:20040857 PMID:20735728 PMID:20958793 PMID:21206266 PMID:21902896 PMID:22180436 PMID:22327826 PMID:22353194 PMID:23731332 PMID:24533960 PMID:24711753 PMID:25275492 PMID:25582404 PMID:25741868 PMID:25828579 PMID:25952977 PMID:26105150 PMID:27227566 PMID:27848944 PMID:28447100 PMID:28492532 PMID:29104756 PMID:29246447 PMID:29318701 PMID:29618153 PMID:31064749 PMID:31273093 PMID:31467667 PMID:31589614 PMID:32333443 PMID:33477601 PMID:34342048 PMID:34355501 PMID:35356632 PMID:35552711 PMID:35802509 PMID:36571800 PMID:36696193 PMID:36719811 PMID:36760778 PMID:37055848 PMID:37091489 PMID:37312209 PMID:37521340 PMID:37761907 PMID:38202056 PMID:38387429 PMID:38397060 More...
NCBI chrNW_004936472:505,751...515,375
Ensembl chrNW_004936472:505,751...514,339
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Fabp3
fatty acid binding protein 3
ISO
RGD
PMID:8326460
RGD:1582401
NCBI chrNW_004936474:14,576,582...14,584,362
Ensembl chrNW_004936474:14,574,891...14,585,706
G
Fga
fibrinogen alpha chain
treatment
ISO
RGD
PMID:31734577
RGD:408418726
NCBI chrNW_004936576:1,322,406...1,329,743
G
Fgb
fibrinogen beta chain
ISO
RGD
PMID:9437197
RGD:1580381
NCBI chrNW_004936576:1,306,076...1,313,485
Ensembl chrNW_004936576:1,306,109...1,313,386
G
Fgf1
fibroblast growth factor 1
treatment
ISO
RGD
PMID:24200746
RGD:10449026
NCBI chrNW_004936504:11,590,687...11,684,410
Ensembl chrNW_004936504:11,590,637...11,685,194
G
Fgfr1
fibroblast growth factor receptor 1
ISO
RGD
PMID:17439742
RGD:10402087
NCBI chrNW_004936710:1,760,365...1,815,269
Ensembl chrNW_004936710:1,760,089...1,815,508
G
Fgfr2
fibroblast growth factor receptor 2
ameliorates
ISO
RGD
PMID:19358330
RGD:155663664
NCBI chrNW_004936486:10,506,680...10,606,272
Ensembl chrNW_004936486:10,507,097...10,602,019
G
Fgg
fibrinogen gamma chain
treatment
ISO
RGD
PMID:31734577
RGD:408418726
NCBI chrNW_004936576:1,343,657...1,352,085
Ensembl chrNW_004936576:1,343,661...1,352,143
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Fis1
fission, mitochondrial 1
ISO
protein:increased expression:plantaris (rat)
RGD
PMID:24427319
RGD:11557988
NCBI chrNW_004936543:1,112,746...1,116,521
Ensembl chrNW_004936543:1,112,742...1,116,518
G
Flt1
fms related receptor tyrosine kinase 1
ISO
RGD
PMID:16714360
RGD:1601493
NCBI chrNW_004936472:23,442,946...23,617,523
Ensembl chrNW_004936472:23,440,088...23,617,041
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Flt3lg
fms related receptor tyrosine kinase 3 ligand
treatment
ISO
RGD
PMID:24184252
RGD:11049498
NCBI chrNW_004936664:3,343,541...3,351,590
Ensembl chrNW_004936664:3,343,491...3,350,176
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Fn1
fibronectin 1
ISO
protein:decreased expression:heart
RGD
PMID:19695229
RGD:2325720
NCBI chrNW_004936586:1,708,803...1,773,372
Ensembl chrNW_004936586:1,708,684...1,773,383
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
ISO
protein:increased expression:paraventricular nucleus hypothalamus, paraventricular nucleus thalamus
RGD
PMID:27601012
RGD:405649741
NCBI chrNW_004936488:4,384,710...4,388,118
Ensembl chrNW_004936488:4,384,705...4,388,122
G
Fto
FTO alpha-ketoglutarate dependent dioxygenase
treatment
ISO
DNA:SNP: :rs17817449 (human) associated with type 2 diabetes mellitus;DNA:SNP:intron:rs9939609 (human) mRNA, protein:decreased expression:heart
RGD
PMID:20031593 PMID:26772723 PMID:29997116
RGD:11555187 RGD:329812009 RGD:329901766
NCBI chrNW_004936475:6,321,725...6,689,410
Ensembl chrNW_004936475:6,321,711...6,689,588
G
Fzd2
frizzled class receptor 2
ISO
mRNA:increased expression:heart left ventricle
RGD
PMID:9142123
RGD:4107058
NCBI chrNW_004936541:965,135...967,018
Ensembl chrNW_004936541:965,131...966,798
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G6pd
glucose-6-phosphate dehydrogenase
treatment
ISO
RGD
PMID:20462747
RGD:10449173
NCBI chrNW_004936809:1,269,900...1,285,853
Ensembl chrNW_004936809:1,269,914...1,285,889
G
Gata4
GATA binding protein 4
treatment
ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:20200331 PMID:23948075
RGD:7327215
NCBI chrNW_004936675:3,408,549...3,420,828
G
Gatm
glycine amidinotransferase
ISO
RGD
PMID:31972362
RGD:329961305
NCBI chrNW_004936471:8,017,611...8,032,703
Ensembl chrNW_004936471:8,017,603...8,032,703
G
Gch1
GTP cyclohydrolase 1
treatment
ISO
RGD
PMID:26192027 PMID:32782412
RGD:329961570 RGD:329970290
NCBI chrNW_004936697:232,048...275,420
G
Gclc
glutamate-cysteine ligase catalytic subunit
susceptibility
ISO
ClinVar Annotator: match by term: GCLC-related condition | ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
OMIM ClinVar
PMID:12598062 PMID:25741868 PMID:28492532
NCBI chrNW_004936476:7,371,270...7,418,756
Ensembl chrNW_004936476:7,371,149...7,418,958
G
Ggt1
gamma-glutamyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19419996
NCBI chrNW_004936619:762,278...791,610
G
Ghrh
growth hormone releasing hormone
treatment
ISO
RGD
PMID:24373935
RGD:10401242
NCBI chrNW_004936561:3,946,256...3,954,472
Ensembl chrNW_004936561:3,950,340...3,952,405
G
Gja1
gap junction protein alpha 1
treatment
ISO
protein:decreased phosphorylation
RGD
PMID:22841862 PMID:22969867 PMID:29428663
RGD:13592597 RGD:7207261 RGD:7207262
NCBI chrNW_004936658:3,920,043...3,932,987
Ensembl chrNW_004936658:3,920,043...3,932,987
G
Gja4
gap junction protein alpha 4
ISO
associated with coronary artery disease; DNA:SNP:CDS:C allele of 1019C>T, amino acid P319S (p = 0.0026) in a Swiss population DNA:SNP:CDS:T allele of 1019C>T in Japanese men (p<0.001)
RGD
PMID:12477941 PMID:15982495 PMID:16677656
RGD:1580400 RGD:1626615 RGD:1626626
NCBI chrNW_004936474:17,439,250...17,440,829
Ensembl chrNW_004936474:17,439,327...17,440,331
G
Gja5
gap junction protein alpha 5
treatment
ISO
RGD
PMID:29428663
RGD:13592597
NCBI chrNW_004936867:269,477...279,549
G
Gp1ba
glycoprotein Ib platelet subunit alpha
ISO
RGD
PMID:15269835
RGD:1580432
NCBI chrNW_004936677:2,774,076...2,779,660
G
Gp6
glycoprotein VI platelet
treatment susceptibility sexual_dimorphism no_association onset
ISO
human protein in a mouse model DNA:SNP, missense mutation:promoter, CDS:c.-148C>T, c.13254T>C (p.S219P) (human) DNA:missense mutation:CDS:c.13254T>C (p.S219P) (human) DNA:missense mutation:CDS:c.13254T>C (p.S219P) (rs1613662) (human) DNA:missense mutation:exon 7:c.645213C>T (p.T249A) (human)
RGD
PMID:11571236 PMID:12417295 PMID:20723028 PMID:22814400
RGD:401793749 RGD:401793754 RGD:401794407 RGD:401824647
NCBI chrNW_004936886:295,950...310,614
Ensembl chrNW_004936886:296,025...310,614
G
Gpt
glutamic--pyruvic transaminase
treatment
ISO
RGD
PMID:32026788
RGD:401793703
NCBI chrNW_004936470:7,765,810...7,770,837
Ensembl chrNW_004936470:7,765,703...7,768,465
G
Gpx1
glutathione peroxidase 1
susceptibility
ISO
RGD
PMID:14573732
RGD:1600662
NCBI chrNW_004936529:997,943...999,123
Ensembl chrNW_004936529:998,150...998,987
G
Gsk3b
glycogen synthase kinase 3 beta
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:16565311 PMID:16716347
RGD:10045368
NCBI chrNW_004936536:6,730,070...6,893,818
Ensembl chrNW_004936536:6,730,062...6,894,303
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Gsn
gelsolin
ameliorates
ISO
protein:decreased expression:blood serum (human)
RGD
PMID:9142022 PMID:28622474
RGD:329333022 RGD:329333030
NCBI chrNW_004936487:9,749,755...9,802,787
Ensembl chrNW_004936487:9,764,944...9,802,841
G
Gsr
glutathione-disulfide reductase
treatment
ISO
RGD
PMID:25119867
RGD:10401898
NCBI chrNW_004936792:531,076...579,083
Ensembl chrNW_004936792:531,756...579,166
G
Gucy1a1
guanylate cyclase 1 soluble subunit alpha 1
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to, 1
ClinVar
PMID:24213632
NCBI chrNW_004936576:2,353,874...2,411,747
Ensembl chrNW_004936576:2,353,761...2,411,425
G
Hadh
hydroxyacyl-CoA dehydrogenase
ISO
RGD
PMID:11481570
RGD:2302229
NCBI chrNW_004936818:575,272...623,496
Ensembl chrNW_004936818:575,023...623,568
G
Hamp
hepcidin antimicrobial peptide
ISO
mRNA:increased expression:heart
RGD
PMID:19615879
RGD:11041636
NCBI chrNW_004936570:1,009,344...1,010,654
Ensembl chrNW_004936570:1,009,312...1,010,686
G
Hfe
homeostatic iron regulator
no_association susceptibility
ISO
RGD
PMID:10491370 PMID:12850485
RGD:1582672 RGD:1582697
NCBI chrNW_004936671:1,940,079...1,947,574
Ensembl chrNW_004936671:1,940,101...1,947,580
G
Hgf
hepatocyte growth factor
treatment
ISO
protein:increased expression:serum:
RGD
PMID:12419930 PMID:16570015
RGD:8548609 RGD:8548632
NCBI chrNW_004936734:354,798...428,356
Ensembl chrNW_004936734:356,115...428,779
G
Hif1a
hypoxia inducible factor 1 subunit alpha
treatment ameliorates
ISO
human gene in a rat model mRNA:increased expression:heart left ventricle
RGD
PMID:15247145 PMID:15999059 PMID:18484163 PMID:28622474
RGD:1580977 RGD:329333030 RGD:5147886 RGD:9068466
NCBI chrNW_004936495:5,770,988...5,816,157
Ensembl chrNW_004936495:5,770,669...5,816,157
G
Hmgb1
high mobility group box 1
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21113057 PMID:23188125
RGD:10402174
NCBI chrNW_004936472:25,236,728...25,246,585
Ensembl chrNW_004936472:25,236,728...25,246,580
G
Hmox1
heme oxygenase 1
ISO
RGD
PMID:12392996 PMID:20925964
RGD:1598393 RGD:4145134
NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311
G
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
ameliorates
ISO
RGD
PMID:26465199 PMID:28522730
RGD:11087531 RGD:329902054
NCBI chrNW_004936557:3,358,809...3,403,461
Ensembl chrNW_004936557:3,357,016...3,403,714
G
Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
ISO
CTD Direct Evidence: marker/mechanism mRNA:increased expression:heart
CTD RGD
PMID:17587755
RGD:2308939
NCBI chrNW_004936475:17,882,663...17,888,708
Ensembl chrNW_004936475:17,882,575...17,887,748
G
Hspa5
heat shock protein family A (Hsp70) member 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25450231
NCBI chrNW_004936487:13,348,465...13,352,717
Ensembl chrNW_004936487:13,348,465...13,352,717
G
Hspd1
heat shock protein family D (Hsp60) member 1
ISO
RGD
PMID:17202668
RGD:1624230
NCBI chrNW_004936506:1,678,069...1,687,632
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Icam1
intercellular adhesion molecule 1
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:10070497 PMID:23139358
RGD:8547733
NCBI chrNW_004936659:616,570...627,172
Ensembl chrNW_004936659:616,752...627,174
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Igf1
insulin like growth factor 1
severity
ISO
mRNA, protein:increased expression:myocardium
RGD
PMID:16635594 PMID:19295919
RGD:1598421 RGD:2306696
NCBI chrNW_004936492:11,709,623...11,784,028
Ensembl chrNW_004936492:11,709,222...11,778,351
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Igf1r
insulin like growth factor 1 receptor
ISO
mRNA,protein:increased expression:myocyte:
RGD
PMID:8682060
RGD:10046050
NCBI chrNW_004936483:4,563,995...4,860,231
Ensembl chrNW_004936483:4,564,512...4,852,925
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Il10
interleukin 10
susceptibility
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:15466015 PMID:15883752 PMID:16310260
RGD:1598480
NCBI chrNW_004936557:5,834,874...5,838,502
Ensembl chrNW_004936557:5,834,874...5,838,502
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Il17a
interleukin 17A
ISO
mRNA, protein:increased expression:heart left ventricle (rat)
RGD
PMID:23096364
RGD:9095344
NCBI chrNW_004936476:8,621,860...8,625,008
Ensembl chrNW_004936476:8,621,860...8,625,008
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Il18
interleukin 18
ameliorates
ISO
RGD
PMID:33389498
RGD:242905187
NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189
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Il18bp
interleukin 18 binding protein
ISO
RGD
PMID:19805173
RGD:4889400
NCBI chrNW_004936498:1,353,569...1,358,312
Ensembl chrNW_004936498:1,355,749...1,361,117
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Il1b
interleukin 1 beta
ameliorates
ISO
protein:increased expression:serum (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:11743230 PMID:15883752 PMID:16310260 PMID:23143013 PMID:23237935 PMID:33389498 More...
RGD:242905187 RGD:7175553 RGD:7204425
NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165
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Il1rn
interleukin 1 receptor antagonist
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18474815 PMID:19005744
NCBI chrNW_004936783:1,447,158...1,466,331
Ensembl chrNW_004936783:1,447,106...1,466,340
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Il4r
interleukin 4 receptor
ISO
mRNA:increased expression:heart
RGD
PMID:10807530
RGD:4889985
NCBI chrNW_004936501:11,025,590...11,058,807
Ensembl chrNW_004936501:11,025,567...11,058,818
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Il6
interleukin 6
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15883752 PMID:16310260 PMID:31734577
RGD:408418726
NCBI chrNW_004936549:7,015,595...7,016,246
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Il6r
interleukin 6 receptor
ISO
RGD
PMID:12123772
RGD:1625444
NCBI chrNW_004936580:4,055,438...4,081,876
Ensembl chrNW_004936580:4,057,771...4,081,885
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Inhba
inhibin subunit beta A
ISO
mRNA:increased expression:myocardium (mouse) mRNA:increased expression:heart (rat)
RGD
PMID:14993131 PMID:32427381
RGD:1580888 RGD:329849118
NCBI chrNW_004936478:16,878,725...16,884,065
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Inhbb
inhibin subunit beta B
ISO
mRNA:increased expression:myocardium (mouse)
RGD
PMID:32427381
RGD:329849118
NCBI chrNW_004936469:50,186,036...50,191,455
Ensembl chrNW_004936469:50,186,036...50,191,461
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Isl1
ISL LIM homeobox 1
ameliorates
ISO
RGD
PMID:22727192 PMID:29482621
RGD:243048463 RGD:243048464
NCBI chrNW_004936480:15,805,259...15,817,854
Ensembl chrNW_004936480:15,805,247...15,817,854
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Itga2
integrin subunit alpha 2
no_association susceptibility
ISO
RGD
PMID:10194421 PMID:15227729 PMID:16697311
RGD:1581029 RGD:1582294 RGD:1582296
NCBI chrNW_004936480:14,320,292...14,417,828
Ensembl chrNW_004936480:14,320,692...14,417,786
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Itga3
integrin subunit alpha 3
ISO
protein:increased expression:myocardium (rat)
RGD
PMID:19041328
RGD:2325287
NCBI chrNW_004936490:11,553,904...11,583,387
Ensembl chrNW_004936490:11,553,861...11,583,380
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Itgam
integrin subunit alpha M
treatment
ISO
RGD
PMID:29933226
RGD:329853753
NCBI chrNW_004936543:8,460,526...8,508,524
Ensembl chrNW_004936543:8,461,307...8,508,524
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Itgb1
integrin subunit beta 1
treatment
ISO
RGD
PMID:28367125
RGD:13602094
NCBI chrNW_004936574:1,465,981...1,495,717
Ensembl chrNW_004936574:1,465,897...1,495,762
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Itgb3
integrin subunit beta 3
no_association susceptibility
ISO
DNA:polymorphism:exon: ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
RGD OMIM ClinVar
PMID:1371279 PMID:2014236 PMID:7570918 PMID:8598867 PMID:8667943 PMID:8838346 PMID:9215749 PMID:9351872 PMID:9376589 PMID:9450787 PMID:9536098 PMID:9700201 PMID:9716140 PMID:9790984 PMID:10531147 PMID:10583927 PMID:10727448 PMID:11723016 PMID:11806996 PMID:14629479 PMID:16199547 PMID:16463284 PMID:17264806 PMID:17576681 PMID:19691478 PMID:20020534 PMID:20106508 PMID:21781244 PMID:21917754 PMID:22250950 PMID:24236036 PMID:25373348 PMID:25539746 PMID:25728920 PMID:25741868 PMID:26096001 PMID:27469266 PMID:28492532 PMID:28748566 PMID:28983057 PMID:31565851 PMID:32237906 PMID:32581362 PMID:32757236 PMID:33718801 PMID:34066320 PMID:36122578 More...
RGD:5128481 RGD:5128498
NCBI chrNW_004936541:2,822,789...2,871,069
Ensembl chrNW_004936541:2,815,738...2,871,035
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Itih4
inter-alpha-trypsin inhibitor heavy chain 4
ISO
RGD
PMID:10486281
RGD:1582334
NCBI chrNW_004936473:3,573,282...3,589,345
Ensembl chrNW_004936473:3,573,384...3,589,345
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Jak2
Janus kinase 2
susceptibility
ISO
associated with Myocardial Reperfusion Injury
RGD
PMID:22749532
RGD:10403083
NCBI chrNW_004936503:111,722...243,627
Ensembl chrNW_004936503:110,963...241,867
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Kcnj2
potassium inwardly rectifying channel subfamily J member 2
treatment
ISO
RGD
PMID:23647964
RGD:7247426
NCBI chrNW_004936655:3,447,026...3,459,569
Ensembl chrNW_004936655:3,447,321...3,458,312
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Kcnk2
potassium two pore domain channel subfamily K member 2
ISO
mRNA:decreased expression:heart left ventricle, epicardium, endocardium (rat)
RGD
PMID:21683547
RGD:9831182
NCBI chrNW_004936628:3,155,261...3,284,375
Ensembl chrNW_004936628:3,154,109...3,345,660
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Kcnn4
potassium calcium-activated channel subfamily N member 4
susceptibility
ISO
DNA:SNPs,haplotypes:introns:multiple
RGD
PMID:19644414
RGD:329969896
NCBI chrNW_004936706:940,585...952,484
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Kdm5b
lysine demethylase 5B
ameliorates
ISO
RGD
PMID:36481938
RGD:329901769
NCBI chrNW_004936567:1,782,056...1,860,861
Ensembl chrNW_004936567:1,781,995...1,863,461
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Kdm6a
lysine demethylase 6A
ISO
mRNA:increased expression:myocardium (rat)
RGD
PMID:30887465
RGD:151665136
NCBI chrNW_004936502:10,980,303...11,196,711
Ensembl chrNW_004936502:10,980,118...11,196,163
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Kdr
kinase insert domain receptor
treatment
ISO
RGD
PMID:16698275 PMID:25936512
RGD:126925214 RGD:1581717
NCBI chrNW_004936482:17,537,697...17,581,320
Ensembl chrNW_004936482:17,538,864...17,581,002
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Kif6
kinesin family member 6
no_association treatment
ISO
DNA:SNP: :rs20455 (human) CTD Direct Evidence: marker/mechanism DNA:SNP: :p.W719R (rs20455) (human)
RGD CTD
PMID:18222354 PMID:19371834 PMID:20403483 PMID:20927332 PMID:21943003 PMID:26997531 More...
RGD:11097528 RGD:243048446 RGD:243048447 RGD:243048449 RGD:243048450
NCBI chrNW_004936476:19,937,141...20,311,988
Ensembl chrNW_004936476:19,937,219...20,311,249
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Klf13
KLF transcription factor 13
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29122578
NCBI chrNW_004936483:477,490...575,143
Ensembl chrNW_004936483:532,736...575,237
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Klk1
kallikrein 1
ISO
CTD Direct Evidence: therapeutic
RGD CTD
PMID:12411458 PMID:17022964
RGD:1641799
NCBI chrNW_004936889:534,127...537,913
Ensembl chrNW_004936889:534,161...537,913
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Lamp2
lysosomal associated membrane protein 2
ISO
mRNA:increased expression:plantaris
RGD
PMID:24427319
RGD:11557988
NCBI chrNW_004936479:9,584,221...9,622,330
Ensembl chrNW_004936479:9,584,221...9,610,420
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Lcat
lecithin-cholesterol acyltransferase
ISO
RGD
PMID:16640830
RGD:1581773
NCBI chrNW_004936475:18,294,013...18,297,433
Ensembl chrNW_004936475:18,293,716...18,298,248
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Lcn2
lipocalin 2
ameliorates
ISO
RGD
PMID:27800610
RGD:126790572
NCBI chrNW_004936487:15,721,752...15,725,396
Ensembl chrNW_004936487:15,721,684...15,728,221
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Ldha
lactate dehydrogenase A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:3279722
NCBI chrNW_004936528:866,607...879,977
G
Lgals2
galectin 2
susceptibility
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
OMIM ClinVar
PMID:15129282
NCBI chrNW_004936492:3,463,195...3,500,431
Ensembl chrNW_004936492:3,483,572...3,488,730
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Lgals3
galectin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29769800
NCBI chrNW_004936697:20,861...38,568
Ensembl chrNW_004936697:27,145...38,586
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Lipg
lipase G, endothelial type
susceptibility
ISO
DNA:polymorphism: :584C>T (human)
RGD
PMID:17526978
RGD:1641818
NCBI chrNW_004936497:13,406,402...13,429,833
Ensembl chrNW_004936497:13,406,357...13,429,890
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LOC101960095
antileukoproteinase
treatment
ISO
RGD
PMID:23361363
RGD:9999400
NCBI chrNW_004936514:7,618,382...7,620,790
Ensembl chrNW_004936514:7,618,261...7,620,912
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LOC101967032
cytochrome b-245 light chain
ISO
mRNA:increase expression:ventricle myocardium: mRNA:increased expression:myocardium
RGD
PMID:11243862 PMID:18762777
RGD:1599690 RGD:2317860
NCBI chrNW_004936641:1,036,967...1,044,954
Ensembl chrNW_004936641:1,036,967...1,044,991
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LOC101968921
angiotensin-converting enzyme
treatment susceptibility
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to associated with Diabetes Mellitus, Type 1;DNA:deletion:intron:IVS16+1464-1751del (human)
RGD ClinVar
PMID:1313972 PMID:1319114 PMID:1328889 PMID:1386652 PMID:1976655 PMID:2847529 PMID:2849100 PMID:7555560 PMID:7593601 PMID:7729604 PMID:7783416 PMID:7854377 PMID:7909524 PMID:8131299 PMID:8131300 PMID:8136829 PMID:8170965 PMID:8208911 PMID:8298638 PMID:8314010 PMID:8541160 PMID:8644984 PMID:8675669 PMID:9120002 PMID:9236417 PMID:9259580 PMID:9699903 PMID:9737775 PMID:9916793 PMID:10099885 PMID:10636736 PMID:10643899 PMID:10841123 PMID:11687636 PMID:11956052 PMID:12220450 PMID:12666117 PMID:14657821 PMID:14872014 PMID:15110771 PMID:15277638 PMID:15381116 PMID:15531537 PMID:15534175 PMID:15635071 PMID:15671045 PMID:19221299 PMID:23959549 PMID:25741868 PMID:28492532 More...
RGD:1558664 RGD:7829785 RGD:9685449
NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177
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LOC101969021
somatotropin
treatment
ISO
RGD
PMID:12500159
RGD:11352745
NCBI chrNW_004936541:4,524,397...4,528,234
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LOC101970101
cytochrome P450 1B1
ameliorates
ISO
RGD
PMID:33389498
RGD:242905187
NCBI chrNW_004936663:345,021...355,188
Ensembl chrNW_004936663:348,368...355,191
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LOC101972165
myosin-7
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:11743230 PMID:15090263
RGD:11565830
NCBI chrNW_004936722:967,443...991,530
Ensembl chrNW_004936722:969,384...991,129
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LOC101972957
vitamin D 25-hydroxylase
ISO
DNA:SNP:CDS:rs2060793, rs1993116, rs10766197 (human)
RGD
PMID:29804528
RGD:401901167
NCBI chrNW_004936528:3,881,630...3,897,613
Ensembl chrNW_004936528:3,881,087...3,900,302
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LOC101973578
adenosine receptor A3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12160945 PMID:20132822
NCBI chrNW_004936690:152,777...168,411
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LOC101976500
haptoglobin
susceptibility
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:2613263 PMID:3990081 PMID:16597321 PMID:17068284 PMID:17207726
RGD:1626354 RGD:1626360
NCBI chrNW_004936475:21,841,054...21,845,821
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LOC101977655
glutamate--cysteine ligase regulatory subunit
susceptibility
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
OMIM ClinVar
PMID:12081989 PMID:12975258
NCBI chrNW_004936537:5,356,914...5,378,998
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Lox
lysyl oxidase
ISO
RGD
PMID:14553832
RGD:1581883
NCBI chrNW_004936575:2,526,067...2,533,996
Ensembl chrNW_004936575:2,524,342...2,533,559
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Lpl
lipoprotein lipase
susceptibility
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP: :p.D9N (rs1801177) (human)
RGD
PMID:18823627
RGD:2313302
NCBI chrNW_004936555:4,084,099...4,108,219
Ensembl chrNW_004936555:4,084,099...4,108,365
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Lrp1
LDL receptor related protein 1
susceptibility
ISO
RGD
PMID:12402342
RGD:1581913
NCBI chrNW_004936646:1,326,900...1,407,236
Ensembl chrNW_004936646:1,327,374...1,406,456
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Lrp8
LDL receptor related protein 8
susceptibility onset no_association
ISO
ClinVar Annotator: match by term: LRP8-related condition | ClinVar Annotator: match by term: Myocardial infarction, susceptibility to, 1 DNA:missense mutation:cds:p.R952Q (human)
OMIM ClinVar RGD
PMID:17847002 PMID:18592168 PMID:25741868 PMID:28492532
RGD:2306124 RGD:2306125
NCBI chrNW_004936522:7,740,887...7,820,488
Ensembl chrNW_004936522:7,740,887...7,816,297
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Lrpap1
LDL receptor related protein associated protein 1
susceptibility
ISO
RGD
PMID:12394648
RGD:1581922
NCBI chrNW_004936477:20,234,582...20,250,756
Ensembl chrNW_004936477:20,234,533...20,250,751
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Lta
lymphotoxin alpha
susceptibility severity no_association
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to DNA:SNP:exon:804C>A (p.T26N) (human)
OMIM ClinVar RGD
PMID:12426569 PMID:12746914 PMID:14681301 PMID:15175864 PMID:15266304 PMID:23398946 More...
RGD:1581940 RGD:8548841
NCBI chrNW_004936727:1,940,081...1,941,022
Ensembl chrNW_004936727:1,940,081...1,941,022
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Map1lc3a
microtubule associated protein 1 light chain 3 alpha
treatment
ISO
RGD
PMID:20079142
RGD:11561913
NCBI chrNW_004936561:6,104,748...6,106,348
Ensembl chrNW_004936561:6,104,742...6,106,699
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Map3k5
mitogen-activated protein kinase kinase kinase 5
treatment
ISO
RGD
PMID:22635076
RGD:10412335
NCBI chrNW_004936560:3,988,696...4,197,953
Ensembl chrNW_004936560:3,989,420...4,197,501
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Map3k7
mitogen-activated protein kinase kinase kinase 7
treatment
ISO
mRNA, protein:increased expression:myocardium (rat)
RGD
PMID:16183734 PMID:27121011
RGD:11073666 RGD:2298758
NCBI chrNW_004936510:1,772,971...1,836,075
Ensembl chrNW_004936510:1,772,971...1,837,765
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Mapk1
mitogen-activated protein kinase 1
ISO
RGD
PMID:15653762
RGD:1582282
NCBI chrNW_004936619:1,889,841...1,932,646
Ensembl chrNW_004936619:1,889,708...1,932,646
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Mapk14
mitogen-activated protein kinase 14
ameliorates
ISO
RGD
PMID:33409963
RGD:401794430
NCBI chrNW_004936476:23,237,762...23,310,211
Ensembl chrNW_004936476:23,237,277...23,310,232
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Mapk8
mitogen-activated protein kinase 8
ameliorates
ISO
RGD
PMID:28622474
RGD:329333030
NCBI chrNW_004936728:1,775,746...1,893,895
Ensembl chrNW_004936728:1,775,641...1,893,907
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Mdh2
malate dehydrogenase 2
ISO
RGD
PMID:9753871
RGD:1582468
NCBI chrNW_004936543:2,194,074...2,208,626
Ensembl chrNW_004936543:2,194,032...2,208,651
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Mdk
midkine
ISO
RGD
PMID:9568069
RGD:1582488
NCBI chrNW_004936562:2,687,825...2,690,292
Ensembl chrNW_004936562:2,687,825...2,689,484
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Mef2c
myocyte enhancer factor 2C
treatment
ISO
RGD
PMID:23948075
RGD:7327215
NCBI chrNW_004936469:7,060,480...7,225,497
Ensembl chrNW_004936469:7,060,480...7,204,661
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Meox2
mesenchyme homeobox 2
ISO
protein:decreased expression:heart (rat)
RGD
PMID:24155330
RGD:155882536
NCBI chrNW_004936546:2,239,442...2,304,099
Ensembl chrNW_004936546:2,239,442...2,304,099
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Mesp1
mesoderm posterior bHLH transcription factor 1
treatment
ISO
human gene and cell line in a rat model
RGD
PMID:32550911
RGD:242905196
NCBI chrNW_004936483:15,533,264...15,534,576
Ensembl chrNW_004936483:15,533,522...15,534,576
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Mff
mitochondrial fission factor
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:23867156
RGD:12879458
NCBI chrNW_004936525:8,604,478...8,636,352
Ensembl chrNW_004936525:8,604,481...8,636,357
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Mfn2
mitofusin 2
treatment
ISO
RGD
PMID:20886221
RGD:12738232
NCBI chrNW_004936474:767,754...795,258
Ensembl chrNW_004936474:767,671...796,556
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Mgp
matrix Gla protein
susceptibility
ISO
RGD
PMID:11073842
RGD:1582503
NCBI chrNW_004936587:2,601,419...2,605,848
Ensembl chrNW_004936587:2,601,312...2,605,870
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Mif
macrophage migration inhibitory factor
ISO
protein:increased expression:plasma mRNA, protein:increased expression:myocardium
RGD
PMID:11589847 PMID:12704210
RGD:1642003 RGD:1642008
NCBI chrNW_004936619:1,207,058...1,208,010
Ensembl chrNW_004936619:1,203,746...1,208,442
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Mlxipl
MLX interacting protein like
susceptibility
ISO
DNA:SNP:cd: C771G, p.Q241H (rs3812316) (human)
RGD
PMID:24448738
RGD:401799621
NCBI chrNW_004936543:2,839,105...2,856,997
Ensembl chrNW_004936543:2,839,105...2,857,002
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Mmp1
matrix metallopeptidase 1
susceptibility
ISO
associated with Coronary Artery Disease; DNA:snps, haplotype:promoter:g.-519A>G, g.-340T>C (human) human gene in rat model protein:increased expression, increased activity:heart left ventricle (rat)
RGD
PMID:8531210 PMID:11179039 PMID:15009768 PMID:16210545 PMID:19797822
RGD:1582520 RGD:1582535 RGD:7207135 RGD:7207136 RGD:7207198
NCBI chrNW_004936551:5,167,909...5,175,149
Ensembl chrNW_004936551:5,168,044...5,174,857
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Mmp13
matrix metallopeptidase 13
ISO
RGD
PMID:15782494
RGD:1582556
NCBI chrNW_004936551:5,040,084...5,050,384
Ensembl chrNW_004936551:5,040,084...5,050,384
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Mmp14
matrix metallopeptidase 14
ISO
RGD
PMID:10773235 PMID:16461815
RGD:1582569 RGD:1582587
NCBI chrNW_004936722:1,447,189...1,457,632
Ensembl chrNW_004936722:1,447,335...1,457,611
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Mmp2
matrix metallopeptidase 2
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:10773235 PMID:11179039 PMID:16310260 PMID:24358288
RGD:1582587 RGD:7207136
NCBI chrNW_004936475:7,801,356...7,825,831
Ensembl chrNW_004936475:7,801,277...7,825,851
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Mmp7
matrix metallopeptidase 7
ISO
RGD
PMID:16769909
RGD:1582373
NCBI chrNW_004936551:5,388,456...5,395,071
Ensembl chrNW_004936551:5,388,459...5,395,071
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Mmp9
matrix metallopeptidase 9
susceptibility
ISO
DNA:snps:promoter, exon:g.-1562C>T, p.R279Q (rs3918242, rs2664538) (human) protein:increased expression, increased activity:heart left ventricle (rat) protein:increased expression:coronary artery, plasma (human) CTD Direct Evidence: marker/mechanism protein:increased expression:heart left ventricle
RGD CTD
PMID:8531210 PMID:14729404 PMID:15118287 PMID:16310260 PMID:16845718 PMID:17893005 PMID:24358288 PMID:25520329 More...
RGD:13204799 RGD:1582639 RGD:1582645 RGD:1582653 RGD:7207049 RGD:7207198
NCBI chrNW_004936514:7,038,240...7,045,873
Ensembl chrNW_004936514:7,037,639...7,045,793
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Mstn
myostatin
ISO
mRNA:decreased expression:myocardium (mouse)
RGD
PMID:32427381
RGD:329849118
NCBI chrNW_004936506:7,988,879...7,996,260
Ensembl chrNW_004936506:7,988,718...7,996,971
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Mthfr
methylenetetrahydrofolate reductase
susceptibility
ISO
DNA:SNP: :677C>T (human) associated with Kidney Failure, Chronic; DNA:transition:cds:g.677C>T rs1801133 (human)
RGD
PMID:10090925 PMID:19272686
RGD:10449412 RGD:6893548
NCBI chrNW_004936474:623,438...637,849
Ensembl chrNW_004936474:623,291...638,193
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Mtor
mechanistic target of rapamycin kinase
treatment
ISO
associated with Diabetes Mellitus, Experimental protein:decreased serine phosphorylation:heart
RGD
PMID:20352476 PMID:23773982
RGD:10041035 RGD:10041040
NCBI chrNW_004936474:158,376...282,310
Ensembl chrNW_004936474:157,590...282,342
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Ncam1
neural cell adhesion molecule 1
ISO
protein:alternative form, increased expression:myocardium mRNA, protein:increased expression:heart
RGD
PMID:19853610 PMID:23462508
RGD:2325979 RGD:40924663
NCBI chrNW_004936612:1,262,557...1,556,281
Ensembl chrNW_004936612:1,262,544...1,556,016
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Ndufb5
NADH:ubiquinone oxidoreductase subunit B5
treatment
ISO
RGD
PMID:24692845
RGD:13801194
NCBI chrNW_004936566:3,537,983...3,547,807
Ensembl chrNW_004936566:3,537,609...3,547,769
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Nfe2l2
NFE2 like bZIP transcription factor 2
treatment
ISO
RGD
PMID:23290949 PMID:24915518
RGD:10412734 RGD:10412738
NCBI chrNW_004936509:6,589,967...6,621,171
Ensembl chrNW_004936509:6,590,630...6,620,262
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Nfkbia
NFKB inhibitor alpha
treatment
ISO
RGD
PMID:19616538
RGD:10413879
NCBI chrNW_004936494:9,537,793...9,541,187
Ensembl chrNW_004936494:9,537,008...9,541,612
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Ngf
nerve growth factor
treatment
ISO
protein:increased expression:myocardium
RGD
PMID:20360245
RGD:405100231
NCBI chrNW_004936627:635,784...641,290
Ensembl chrNW_004936627:635,788...645,364
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Nlk
nemo like kinase
ISO
mRNA, protein:decreased expression:heart
RGD
PMID:26861724
RGD:242905213
NCBI chrNW_004936538:4,321,018...4,466,175
Ensembl chrNW_004936538:4,320,907...4,466,168
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Nlrp3
NLR family pyrin domain containing 3
ameliorates
ISO
RGD
PMID:33389498
RGD:242905187
NCBI chrNW_004936864:709,693...732,119
Ensembl chrNW_004936864:709,709...731,718
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Nono
non-POU domain containing octamer binding
ameliorates
ISO
RGD
PMID:35247074
RGD:155882458
NCBI chrNW_004936762:322,413...343,126
Ensembl chrNW_004936762:321,280...341,537
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Nos2
nitric oxide synthase 2
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:10090345 PMID:11489778 PMID:26192027
RGD:329970290
NCBI chrNW_004936538:4,052,277...4,097,051
Ensembl chrNW_004936538:4,052,448...4,097,051
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Nos3
nitric oxide synthase 3
susceptibility treatment
ISO
DNA:duplication:intron:IVS4?-?+27 (human) CTD Direct Evidence: marker/mechanism DNA:repeats:intron protein:decreased expression:aorta (rat) human gene in rat model
RGD CTD
PMID:10510054 PMID:10531147 PMID:11903359 PMID:12362496 PMID:16337503 PMID:17637430 PMID:22012955 PMID:28980197 PMID:29311930 More...
RGD:13450930 RGD:13503346 RGD:1580283 RGD:1580284 RGD:5128481 RGD:7771561 RGD:7771563
NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534
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Npm1
nucleophosmin 1
ISO
protein:increased expression:cardiomyocyte:
RGD
PMID:21444791
RGD:11535018
NCBI chrNW_004936609:3,712,628...3,725,635
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Nppa
natriuretic peptide A
ISO
DNA:snp:cds:c.2238T>C (human) CTD Direct Evidence: marker/mechanism|therapeutic
RGD CTD
PMID:9527094 PMID:11743230 PMID:12514664 PMID:16087130
RGD:1579982 RGD:1580000
NCBI chrNW_004936474:671,362...673,610
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Nppb
natriuretic peptide B
ISO
RGD
PMID:17256064 PMID:17639095 PMID:19858735
RGD:1642266 RGD:2324680 RGD:7247724
NCBI chrNW_004936474:683,325...684,662
Ensembl chrNW_004936474:683,325...684,665
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Npr1
natriuretic peptide receptor 1
susceptibility
ISO
DNA:missense mutation:cds:p.M341I (human)
RGD
PMID:14646971
RGD:1580174
NCBI chrNW_004936580:3,479,858...3,496,896
Ensembl chrNW_004936580:3,480,267...3,495,643
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Nr1h3
nuclear receptor subfamily 1 group H member 3
susceptibility
ISO
DNA:SNPs, haplotype:promoter:c.-115G>A, c.-840C>A (rs12221497, rs61896015) (human)
RGD
PMID:21903943
RGD:401842365
NCBI chrNW_004936562:1,937,665...1,946,680
Ensembl chrNW_004936562:1,937,667...1,946,669
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Nr3c2
nuclear receptor subfamily 3 group C member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16413583 PMID:17587755
NCBI chrNW_004936535:1,139,687...1,467,469
Ensembl chrNW_004936535:1,140,178...1,467,471
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Nrg1
neuregulin 1
treatment
ISO
RGD
PMID:24200746 PMID:26892146 PMID:27993643
RGD:10449026 RGD:11522702 RGD:405145704
NCBI chrNW_004936766:1,104,841...1,306,368
Ensembl chrNW_004936766:1,104,728...1,305,972
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Nrip1
nuclear receptor interacting protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22503866
NCBI chrNW_004936505:7,886,327...7,966,969
Ensembl chrNW_004936505:7,884,724...7,966,928
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Olr1
oxidized low density lipoprotein receptor 1
susceptibility
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to | ClinVar Annotator: match by term: OLR1-related condition
OMIM ClinVar
PMID:12646194 PMID:12810610 PMID:14684693
NCBI chrNW_004936902:405,536...416,393
Ensembl chrNW_004936902:409,704...416,401
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Opa1
OPA1 mitochondrial dynamin like GTPase
treatment
ISO
RGD
PMID:20886221
RGD:12738232
NCBI chrNW_004936711:1,027,531...1,113,796
Ensembl chrNW_004936711:1,032,935...1,106,847
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Oprd1
opioid receptor delta 1
ISO
RGD
PMID:12798419 PMID:15076225
RGD:2316587 RGD:9831425
NCBI chrNW_004936474:12,860,293...12,902,389
Ensembl chrNW_004936474:12,860,293...12,903,466
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Oprk1
opioid receptor kappa 1
ISO
RGD
PMID:15076225
RGD:9831425
NCBI chrNW_004936496:280,593...305,900
Ensembl chrNW_004936496:280,558...305,904
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P2ry12
purinergic receptor P2Y12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19334620
NCBI chrNW_004936758:1,581,828...1,624,332
Ensembl chrNW_004936758:1,581,897...1,592,222
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Pappa
pappalysin 1
susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:polymorphism:intron
CTD RGD
PMID:11586954 PMID:17700210
RGD:1642324
NCBI chrNW_004936487:5,000,279...5,379,786
Ensembl chrNW_004936487:5,144,044...5,376,367
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Parp1
poly(ADP-ribose) polymerase 1
ISO
protein:altered processing:left ventricle (mouse)
RGD
PMID:21282286
RGD:5684012
NCBI chrNW_004936526:3,102,468...3,147,601
Ensembl chrNW_004936526:3,102,039...3,147,642
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Pcsk2
proprotein convertase subtilisin/kexin type 2
ISO
DNA:SNP:intron: (rs6080699) (human)
RGD
PMID:20036365
RGD:6483554
NCBI chrNW_004936485:2,611,313...2,866,260
Ensembl chrNW_004936485:2,608,353...2,866,294
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Pde3a
phosphodiesterase 3A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19027736
NCBI chrNW_004936548:5,758,634...6,072,195
Ensembl chrNW_004936548:5,762,507...6,070,576
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Pde5a
phosphodiesterase 5A
ISO
RGD
PMID:17339532
RGD:2314468
NCBI chrNW_004936869:24,265...117,120
Ensembl chrNW_004936869:39,122...117,127
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Pdgfd
platelet derived growth factor D
ISO
mRNA,protein:altered expression:myocardium:
RGD
PMID:21767547
RGD:9854703
NCBI chrNW_004936551:3,974,140...4,197,852
Ensembl chrNW_004936551:3,974,104...4,198,927
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Pebp1
phosphatidylethanolamine binding protein 1
ISO
protein:decreased expression:right heart ventricle, ventricular septum
RGD
PMID:17089028
RGD:2302667
NCBI chrNW_004936668:2,316,661...2,323,015
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Pecam1
platelet and endothelial cell adhesion molecule 1
onset no_association
ISO
DNA:polymorphisms: :p.N563S, p.G670R (human) DNA:missense mutations:cds:p.L125V, p.S563N (human) DNA:missense mutation:cds:p.R643G (human)
RGD
PMID:11795274 PMID:15265022 PMID:15488875
RGD:1581009 RGD:2311656 RGD:6771224
NCBI chrNW_004936541:4,873,459...4,919,787
Ensembl chrNW_004936541:4,873,182...4,937,500
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Pgf
placental growth factor
ISO
RGD
PMID:20649603 PMID:21329947 PMID:22114497
RGD:6483584 RGD:6483773 RGD:6483777
NCBI chrNW_004936488:4,098,187...4,111,108
Ensembl chrNW_004936488:4,098,225...4,111,142
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Phactr1
phosphatase and actin regulator 1
susceptibility severity no_association
ISO
CTD Direct Evidence: marker/mechanism mRNA, protein:decreased expression:heart left ventricle (rat) DNA:SNP:intron:g.13035530G>C (rs12526453) (human) DNA:SNP:intron:(rs12526453) (human) DNA:SNP:intron: (rs9369640) (human) DNA:SNPs:intron 3: (rs9349379, rs2026458, rs2876300) (human) DNA:SNPs:multiple (human) mRNA:increased expression:peripheral blood mononuclear cells (human)
CTD RGD
PMID:19198609 PMID:25738804 PMID:25838425 PMID:26086777 PMID:26098115 PMID:33460763 More...
RGD:11052493 RGD:11052994 RGD:11053274 RGD:11056926 RGD:401851907 RGD:401900171
NCBI chrNW_004936534:42,354...323,735
Ensembl chrNW_004936534:42,433...536,171
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Phlda3
pleckstrin homology like domain family A member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34351043
NCBI chrNW_004936567:2,981,632...2,984,906
Ensembl chrNW_004936567:2,981,602...2,984,903
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Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
ISO
RGD
PMID:20056919
RGD:6482688
NCBI chrNW_004936479:17,084,006...17,112,264
Ensembl chrNW_004936479:17,084,920...17,112,258
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Pla2g7
phospholipase A2 group VII
ISO
protein:decreased expression:serum
RGD
PMID:19644070
RGD:6482786
NCBI chrNW_004936476:13,609,847...13,646,174
Ensembl chrNW_004936476:13,609,374...13,649,998
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Plat
plasminogen activator, tissue type
treatment
ISO
CTD Direct Evidence: therapeutic DNA:snp:enhancer:g.-7351C>T (human)
CTD RGD
PMID:1430592 PMID:1492007 PMID:1898952 PMID:1899364 PMID:1900011 PMID:2104561 PMID:2105625 PMID:2494454 PMID:2505604 PMID:2521976 PMID:3089627 PMID:3121335 PMID:7488445 PMID:7723950 PMID:7775709 PMID:7902905 PMID:7994806 PMID:8328192 PMID:8554022 PMID:8598594 PMID:9183334 PMID:10171637 PMID:10505926 PMID:10645301 PMID:10914357 PMID:11382373 PMID:11489769 PMID:11848437 PMID:12074692 PMID:12227717 PMID:12848087 PMID:15215796 PMID:15301905 PMID:18195371 PMID:19341228 PMID:20122609 More...
RGD:11541077 RGD:1580881
NCBI chrNW_004936785:476,200...503,371
Ensembl chrNW_004936785:476,078...503,321
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Plau
plasminogen activator, urokinase
ISO
mRNA, protein:increased expression:myocardium CTD Direct Evidence: marker/mechanism|therapeutic DNA:SNP:3' utr:c.*141C>T (rs4065) (human)
RGD CTD
PMID:1908371 PMID:2174952 PMID:2382605 PMID:3068399 PMID:3984876 PMID:8416330 PMID:17653104 PMID:20518747 PMID:20952728 More...
RGD:6484126 RGD:6484133 RGD:6484145
NCBI chrNW_004936521:5,238,128...5,243,829
Ensembl chrNW_004936521:5,238,093...5,243,877
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Plaur
plasminogen activator, urokinase receptor
ISO
mRNA, protein:increased expression:myocardium
RGD
PMID:12393744 PMID:20952728
RGD:1580897 RGD:6484133
NCBI chrNW_004936706:840,968...855,552
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Plcb1
phospholipase C beta 1
ISO
protein:increased expression:heart
RGD
PMID:9521338
RGD:2314514
NCBI chrNW_004936485:10,548,966...11,254,139
Ensembl chrNW_004936485:10,548,966...11,253,761
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Plcb3
phospholipase C beta 3
ISO
protein:increased expression:heart
RGD
PMID:9521338
RGD:2314514
NCBI chrNW_004936599:4,934,123...4,950,564
Ensembl chrNW_004936599:4,934,060...4,950,570
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Pln
phospholamban
treatment
ISO
protein:decreased expression:heart left ventricle (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16026515 PMID:16162791 PMID:23781262 PMID:26067684
RGD:11097969 RGD:7327176
NCBI chrNW_004936658:1,443,626...1,453,770
Ensembl chrNW_004936658:1,443,795...1,453,839
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Pon1
paraoxonase 1
ISO
RGD
PMID:10610741 PMID:10978258
RGD:1580198 RGD:1580202
NCBI chrNW_004936585:4,954,871...4,979,560
Ensembl chrNW_004936585:4,954,869...4,979,591
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Postn
periostin
ISO
protein:increased expression:heart:
RGD
PMID:24212842
RGD:10041024
NCBI chrNW_004936472:31,644,778...31,677,572
Ensembl chrNW_004936472:31,644,778...31,677,572
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Ppara
peroxisome proliferator activated receptor alpha
ISO
DNA:SNP:intron:rs4253623, minor allele associated with increased risk
RGD
PMID:18549840
RGD:5562819
NCBI chrNW_004936629:3,672,445...3,725,645
Ensembl chrNW_004936629:3,672,460...3,725,626
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Ppargc1a
PPARG coactivator 1 alpha
ISO
CTD Direct Evidence: marker/mechanism protein:decreased expression:heart (rat)
CTD RGD
PMID:22087236 PMID:22503866
RGD:6484266 RGD:7242181
NCBI chrNW_004936477:4,881,230...5,488,208
Ensembl chrNW_004936477:5,199,881...5,488,226
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Prkce
protein kinase C epsilon
ISO
CTD Direct Evidence: therapeutic RNA:decreased expression:myocardium:
CTD RGD
PMID:16782078 PMID:28887629
RGD:155882580
NCBI chrNW_004936508:6,018,374...6,495,216
Ensembl chrNW_004936508:6,017,551...6,494,427
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Prkd1
protein kinase D1
treatment
ISO
RGD
PMID:26064267
RGD:289474908
NCBI chrNW_004936494:4,469,092...4,601,183
Ensembl chrNW_004936494:4,469,089...4,601,214
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
ISO
RGD
PMID:10936861
RGD:11100014
NCBI chrNW_004936469:43,841,989...43,850,322
Ensembl chrNW_004936469:43,841,989...43,850,304
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Psma6
proteasome 20S subunit alpha 6
susceptibility
ISO
ClinVar Annotator: match by term: PSMA6-related condition
OMIM ClinVar
PMID:16845397 PMID:19282875
NCBI chrNW_004936494:9,443,176...9,467,697
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Ptgis
prostaglandin I2 synthase
susceptibility
ISO
DNA:SNP:CDS: (rs5629) (human) DNA:silent mutation:exon 8:1117C>A (human) DNA:SNP::1117C>A (human)
RGD
PMID:12040339 PMID:19040046 PMID:19046748 PMID:19327107
RGD:2313891 RGD:401901147 RGD:401901155 RGD:401901268
NCBI chrNW_004936514:4,775,884...4,814,574
Ensembl chrNW_004936514:4,791,031...4,812,027
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
RGD
PMID:15138244
RGD:1581289
NCBI chrNW_004936481:3,821,564...3,828,086
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Ptn
pleiotrophin
ISO
protein:increased expression:myocardium (rat)
RGD
PMID:17925408
RGD:10044023
NCBI chrNW_004936592:1,706,979...1,806,345
Ensembl chrNW_004936592:1,707,693...1,730,617
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Rad50
RAD50 double strand break repair protein
treatment
ISO
RGD
PMID:15623426
RGD:9831390
NCBI chrNW_004936647:2,546,100...2,637,524
Ensembl chrNW_004936647:2,543,599...2,637,846
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Rbp4
retinol binding protein 4
ISO
protein:increased expression:blood serum (human)
RGD
PMID:25142320
RGD:329845867
NCBI chrNW_004936601:1,401,215...1,410,195
Ensembl chrNW_004936601:1,402,691...1,410,208
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Reg1a
regenerating family member 1 alpha
ISO
mRNA:increased expression:heart left ventricle (rat)
RGD
PMID:15778284
RGD:9850130
NCBI chrNW_004936556:4,873,331...4,875,608
Ensembl chrNW_004936556:4,873,331...4,875,608
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Ren
renin
susceptibility
ISO
associated with Hypertension; protein:increased activity:plasma (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:1668233 PMID:1759997
RGD:6892687
NCBI chrNW_004936567:598,044...607,628
Ensembl chrNW_004936567:598,048...607,497
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Retn
resistin
ISO
protein:increased expression:plasma
RGD
PMID:18997620
RGD:7207152
NCBI chrNW_004936588:4,705,295...4,706,653
Ensembl chrNW_004936588:4,705,119...4,706,656
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Rps6kb1
ribosomal protein S6 kinase B1
ISO
protein:increased threonine phosphorylation:heart left ventricle
RGD
PMID:16540832
RGD:1642998
NCBI chrNW_004936490:3,441,046...3,492,917
Ensembl chrNW_004936490:3,441,055...3,492,917
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Ryr1
ryanodine receptor 1
ISO
protein:hyperphosphorylation:extensor digitorum longus:
RGD
PMID:12824280
RGD:329813076
NCBI chrNW_004936801:1,185,615...1,298,416
Ensembl chrNW_004936801:1,185,733...1,298,289
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Sdc1
syndecan 1
ISO
mRNA:increased expression:myocardium
RGD
PMID:9237025
RGD:2311712
NCBI chrNW_004936493:11,177,804...11,199,678
Ensembl chrNW_004936493:11,177,708...11,199,804
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Sdc4
syndecan 4
ISO
protein:increased expression:plasma
RGD
PMID:11372670
RGD:2312328
NCBI chrNW_004936514:7,528,538...7,562,391
Ensembl chrNW_004936514:7,555,685...7,562,391
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Sell
selectin L
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10070497
NCBI chrNW_004936481:17,022,421...17,032,105
Ensembl chrNW_004936481:17,022,580...17,032,124
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Selp
selectin P
susceptibility
ISO
protein:increased expression:serum DNA:polymorphisms, haplotypes:cds:p.S290N, p.N562D, p.T715P (human) associated with Hypertension;protein:increased expression:plasma
RGD
PMID:12165563 PMID:17391113 PMID:21162967 PMID:21567088
RGD:1580075 RGD:2312304 RGD:6218991 RGD:6219003
NCBI chrNW_004936481:17,076,660...17,112,501
Ensembl chrNW_004936481:17,076,536...17,107,963
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Serpine1
serpin family E member 1
susceptibility
ISO
DNA:deletion:promoter:g.-676_-674delG (human)
RGD
PMID:12477941 PMID:16053971
RGD:1626626 RGD:8547882
NCBI chrNW_004936543:1,032,543...1,040,956
Ensembl chrNW_004936543:1,032,794...1,039,123
G
Sfrp2
secreted frizzled related protein 2
ISO
RGD
PMID:19079247 PMID:19109969
RGD:155883169 RGD:4107088
NCBI chrNW_004936576:604,174...612,440
Ensembl chrNW_004936576:604,069...613,021
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Sh2b3
SH2B adaptor protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19198610
NCBI chrNW_004936558:4,103,898...4,126,883
Ensembl chrNW_004936558:4,104,534...4,123,869
G
Shh
sonic hedgehog signaling molecule
treatment
ISO
RGD
PMID:20052412
RGD:12879408
NCBI chrNW_004936527:10,033,095...10,042,713
Ensembl chrNW_004936527:10,033,299...10,042,599
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Sirt1
sirtuin 1
ISO
protein:altered localization:nucleus
RGD
PMID:20089851
RGD:2316169
NCBI chrNW_004936521:10,296,097...10,316,673
Ensembl chrNW_004936521:10,296,097...10,322,215
G
Sirt3
sirtuin 3
treatment
ISO
RGD
PMID:24471974
RGD:9586050
NCBI chrNW_004936888:63,131...78,536
Ensembl chrNW_004936888:63,546...77,950
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Slc27a1
solute carrier family 27 member 1
ISO
protein:decreased expression:infarcted heart
RGD
PMID:17034771
RGD:1642800
NCBI chrNW_004936596:3,426,807...3,451,259
Ensembl chrNW_004936596:3,427,874...3,449,489
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Slc27a6
solute carrier family 27 member 6
ISO
protein:decreased expression:heart
RGD
PMID:17034771
RGD:1642800
NCBI chrNW_004936504:2,152,449...2,208,295
Ensembl chrNW_004936504:2,152,394...2,208,394
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Smad2
SMAD family member 2
ameliorates treatment
ISO
RGD
PMID:11087260 PMID:33409963
RGD:12903276 RGD:401794430
NCBI chrNW_004936497:14,723,199...14,812,160
Ensembl chrNW_004936497:14,723,199...14,801,697
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Smad3
SMAD family member 3
ameliorates
ISO
RGD
PMID:33409963
RGD:401794430
NCBI chrNW_004936471:27,080,662...27,185,861
Ensembl chrNW_004936471:27,080,575...27,189,793
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Smad4
SMAD family member 4
treatment
ISO
RGD
PMID:11087260
RGD:12903276
NCBI chrNW_004936497:12,242,869...12,278,012
Ensembl chrNW_004936497:12,249,140...12,278,123
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Socs1
suppressor of cytokine signaling 1
ISO
protein:increased expression:heart
RGD
PMID:16377761
RGD:2298918
NCBI chrNW_004936530:9,312,965...9,315,593
Ensembl chrNW_004936530:9,312,965...9,316,165
G
Sod1
superoxide dismutase 1
treatment
ISO
CTD Direct Evidence: therapeutic human gene in a rat model
CTD RGD
PMID:11864929 PMID:21600015 PMID:22006090
RGD:1581222 RGD:8655953
NCBI chrNW_004936500:10,345,154...10,352,873
Ensembl chrNW_004936500:10,345,154...10,352,867
G
Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: therapeutic
RGD CTD
PMID:2313102 PMID:9250167 PMID:12160945 PMID:14575298
RGD:1580839 RGD:1580840 RGD:1581148
NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781
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Sparc
secreted protein acidic and cysteine rich
ISO
mRNA:increased expression:heart
RGD
PMID:12826287
RGD:2300056
NCBI chrNW_004936515:11,026,156...11,046,812
Ensembl chrNW_004936515:11,025,724...11,046,849
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Spp1
secreted phosphoprotein 1
ISO
RGD
PMID:12939547 PMID:14500723
RGD:1581325 RGD:1581386
NCBI chrNW_004936905:148,956...156,023
Ensembl chrNW_004936905:148,945...156,079
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Srsf1
serine and arginine rich splicing factor 1
treatment
ISO
protein:increased phosphorylation:heart left ventricle(rat)
RGD
PMID:26067684
RGD:11097969
NCBI chrNW_004936490:5,055,258...5,059,118
Ensembl chrNW_004936490:5,055,253...5,059,116
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Tbx3
T-box transcription factor 3
ISO
RGD
PMID:19341743
RGD:5132891
NCBI chrNW_004936558:7,230,361...7,243,651
Ensembl chrNW_004936558:7,230,668...7,244,361
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Tbx5
T-box transcription factor 5
treatment
ISO
RGD
PMID:23948075
RGD:7327215
NCBI chrNW_004936558:7,408,229...7,454,897
Ensembl chrNW_004936558:7,408,222...7,454,901
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Tek
TEK receptor tyrosine kinase
ISO
protein:increased expression:ventricle myocardium
RGD
PMID:16714360
RGD:1601493
NCBI chrNW_004936611:2,420,176...2,531,726
Ensembl chrNW_004936611:2,420,172...2,531,722
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Tfpi
tissue factor pathway inhibitor
treatment
ISO
mRNA,protein:increased expression:heart:
RGD
PMID:14656922 PMID:15630488 PMID:21229253
RGD:11060131 RGD:11060139 RGD:11062083
NCBI chrNW_004936506:10,103,120...10,172,800
Ensembl chrNW_004936506:10,103,139...10,171,863
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Tgfb1
transforming growth factor beta 1
susceptibility
ISO
CTD Direct Evidence: marker/mechanism associated with Coronary Disease;DNA:polymorphism:promoter:-509C>T (human) mRNA,protein:increased expression:heart:
CTD RGD
PMID:16310260 PMID:16543493 PMID:27121011
RGD:11073666 RGD:1601560
NCBI chrNW_004936661:3,742,080...3,758,266
Ensembl chrNW_004936661:3,742,066...3,758,272
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Tgfb2
transforming growth factor beta 2
ISO
RGD
PMID:14575314
RGD:2302107
NCBI chrNW_004936628:310,720...394,002
Ensembl chrNW_004936628:308,691...394,007
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Tgfbr1
transforming growth factor beta receptor 1
ISO
RGD
PMID:10198196
RGD:1601617
NCBI chrNW_004936524:7,656,523...7,680,043
Ensembl chrNW_004936524:7,655,847...7,681,097
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Tgfbr2
transforming growth factor beta receptor 2
ISO
protein:increased expression:myocardium
RGD
PMID:10198196
RGD:1601617
NCBI chrNW_004936473:21,324,669...21,409,430
Ensembl chrNW_004936473:21,324,658...21,409,430
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Th
tyrosine hydroxylase
no_association
ISO
DNA:polymorphism:intron:g.1170_1173dupTCAT (human)
RGD
PMID:16139102
RGD:1580048
NCBI chrNW_004936794:478,651...486,887
Ensembl chrNW_004936794:478,614...487,061
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Thbd
thrombomodulin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9843165 PMID:10627464
NCBI chrNW_004936620:2,563,900...2,568,117
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Thbs1
thrombospondin 1
ISO
mRNA, protein:increased expression:myocardium
RGD
PMID:16179730
RGD:2317960
NCBI chrNW_004936471:3,064,466...3,081,125
Ensembl chrNW_004936471:3,064,422...3,081,949
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Timp2
TIMP metallopeptidase inhibitor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24358288
NCBI chrNW_004936594:3,232,433...3,244,241
Ensembl chrNW_004936594:3,232,355...3,244,241
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Tlr4
toll like receptor 4
ISO
DNA:SNP:intron:rs1927911, minor allele associated with decreased risk
RGD
PMID:15864121 PMID:18549840
RGD:1580734 RGD:5562819
NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095
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Tm6sf2
transmembrane 6 superfamily member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24633158
NCBI chrNW_004936596:2,167,285...2,174,211
Ensembl chrNW_004936596:2,167,273...2,174,266
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Tnc
tenascin C
ISO
protein:increased expression:heart, fibroblast
RGD
PMID:11454990
RGD:4889618
NCBI chrNW_004936487:4,172,263...4,256,780
Ensembl chrNW_004936487:4,172,886...4,233,126
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism mRNA, protein:increased expression:left ventricle myocardium, plasma
CTD RGD
PMID:15883752 PMID:16310260 PMID:21362018
RGD:5130892
NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
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Tnfrsf11b
TNF receptor superfamily member 11b
ISO
RGD
PMID:15926884
RGD:1620893
NCBI chrNW_004936470:27,571,263...27,598,725
Ensembl chrNW_004936470:27,571,270...27,599,089
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Tnfrsf12a
TNF receptor superfamily member 12A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20082609
NCBI chrNW_004936694:1,149,169...1,151,098
Ensembl chrNW_004936694:1,149,076...1,151,151
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Tnfrsf14
TNF receptor superfamily member 14
ISO
protein:increased expression:heart, cardiomyocyte, endothelial cell (rat)
RGD
PMID:18353719
RGD:2317281
NCBI chrNW_004936737:1,008,228...1,013,575
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Tnfrsf1a
TNF receptor superfamily member 1A
ISO
mRNA, protein:increased expression:left ventricle myocardium (rat)
RGD
PMID:15117889 PMID:20651834 PMID:21362018
RGD:1624194 RGD:5130892 RGD:5130975
NCBI chrNW_004936709:1,407,327...1,421,448
Ensembl chrNW_004936709:1,407,278...1,421,921
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Tnfrsf1b
TNF receptor superfamily member 1B
ISO
mRNA, protein:decreased expression:left ventricle myocardium (rat)
RGD
PMID:21362018
RGD:5130892
NCBI chrNW_004936474:908,414...935,765
Ensembl chrNW_004936474:908,485...934,177
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Tnfsf11
TNF superfamily member 11
ISO
protein:increased expression:serum
RGD
PMID:18298349
RGD:2302363
NCBI chrNW_004936747:1,255,803...1,288,252
Ensembl chrNW_004936747:1,255,803...1,288,252
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Tnfsf4
TNF superfamily member 4
susceptibility
ISO
CTD Direct Evidence: marker/mechanism
OMIM CTD RGD
PMID:15750594
RGD:1580396
NCBI chrNW_004936481:14,391,359...14,409,514
G
Tnni3
troponin I3, cardiac type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12359538
NCBI chrNW_004936886:437,754...440,925
Ensembl chrNW_004936886:437,754...440,458
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Tnnt2
troponin T2, cardiac type
ISO
RGD
PMID:15226628
RGD:1580441
NCBI chrNW_004936567:3,052,167...3,069,077
Ensembl chrNW_004936567:3,056,845...3,068,887
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Tp53
tumor protein p53
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24358288
NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425
G
Trem1
triggering receptor expressed on myeloid cells 1
disease_progression ameliorates
ISO
RGD
PMID:25840803
RGD:127284842
NCBI chrNW_004936476:18,577,825...18,583,675
Ensembl chrNW_004936476:18,574,381...18,583,647
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Trpv1
transient receptor potential cation channel subfamily V member 1
ISO
RGD
PMID:27671317
RGD:13792689
NCBI chrNW_004936677:277,304...326,907
Ensembl chrNW_004936677:276,994...327,025
G
Ttn
titin
ISO
RGD
PMID:12221049
RGD:1580780
NCBI chrNW_004936509:7,733,426...7,999,503
G
Txn
thioredoxin
ISO
RGD
PMID:14677813
RGD:1580785
NCBI chrNW_004936559:2,811,786...2,822,528
Ensembl chrNW_004936559:2,811,782...2,822,528
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Txnrd1
thioredoxin reductase 1
ISO
mRNA:decreased expression:heart left ventricle (rat)
RGD
PMID:18515646
RGD:5134341
NCBI chrNW_004936492:10,185,096...10,244,466
Ensembl chrNW_004936492:10,187,206...10,225,989
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Ubd
ubiquitin D
ISO
mRNA, protein; increased expression; myocardium (rat)
RGD
PMID:29438664
RGD:126925221
NCBI chrNW_004936723:1,218,621...1,221,070
Ensembl chrNW_004936723:1,218,258...1,221,451
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Uts2
urotensin 2
ISO
associated with Heart Failure, Congestive;mRNA:increased expression:heart ventricle
RGD
PMID:15549273
RGD:2306846
NCBI chrNW_004936623:2,339,259...2,345,717
Ensembl chrNW_004936623:2,340,778...2,345,700
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Uts2r
urotensin 2 receptor
ISO
associated with Heart Failure, Congestive;mRNA:increased expression:heart ventricle
RGD
PMID:15549273
RGD:2306846
NCBI chrNW_004936923:24,952...31,083
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Vcan
versican
ISO
RGD
PMID:16311904
RGD:1598497
NCBI chrNW_004936469:2,585,142...2,688,029
Ensembl chrNW_004936469:2,585,134...2,688,029
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Vdac1
voltage dependent anion channel 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25488258
NCBI chrNW_004936647:1,220,075...1,249,579
Ensembl chrNW_004936647:1,230,450...1,249,814
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Vdac2
voltage dependent anion channel 2
treatment
ISO
RGD
PMID:20601275
RGD:10003049
NCBI chrNW_004936521:4,122,447...4,136,228
Ensembl chrNW_004936521:4,122,270...4,136,380
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Vegfa
vascular endothelial growth factor A
treatment
ISO
protein:increased expression:serum,platelet:
RGD
PMID:10652191 PMID:25936512
RGD:126925214 RGD:7483604
NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673
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Vegfb
vascular endothelial growth factor B
ISO
RGD
PMID:17975666
RGD:2314324
NCBI chrNW_004936599:4,963,161...4,966,258
Ensembl chrNW_004936599:4,962,222...4,966,264
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Vwf
von Willebrand factor
ISO
protein:increased expression:heart:
RGD
PMID:19435557
RGD:11080745
NCBI chrNW_004936709:1,578,137...1,741,877
Ensembl chrNW_004936709:1,579,096...1,741,754
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Wdr12
WD repeat domain 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19198609 PMID:25915632
NCBI chrNW_004936726:1,931,221...1,958,457
Ensembl chrNW_004936726:1,931,183...1,958,215
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Wrn
WRN RecQ like helicase
ISO
RGD
PMID:9021029
RGD:1580821
NCBI chrNW_004936792:862,659...1,005,065
Ensembl chrNW_004936792:862,383...1,005,755
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Xrcc3
X-ray repair cross complementing 3
susceptibility
ISO
DNA:polymorphism:: (human)
RGD
PMID:18712175
RGD:401827276
NCBI chrNW_004936621:1,462,441...1,474,937
Ensembl chrNW_004936621:1,462,428...1,473,868
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Zeb2
zinc finger E-box binding homeobox 2
ISO
protein:increased expression:heart (rat)
RGD
PMID:24155330
RGD:155882536
NCBI chrNW_004936469:32,240,730...32,372,413
Ensembl chrNW_004936469:32,240,835...32,371,267
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Abcc8
ATP binding cassette subfamily C member 8
ISO
RGD
PMID:18316485
RGD:2301903
NCBI chrNW_004936528:1,608,782...1,682,873
Ensembl chrNW_004936528:1,608,757...1,682,975
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Acvr2b
activin A receptor type 2B
treatment
ISO
human construct in mouse model mRNA, protein:decreased expression:heart (mouse)
RGD
PMID:30765322
RGD:329849112
NCBI chrNW_004936473:27,816,366...27,822,555
Ensembl chrNW_004936473:27,815,399...27,822,476
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Ada
adenosine deaminase
ISO
protein:increased expression
RGD
PMID:16641873
RGD:1624305
NCBI chrNW_004936530:2,217,713...2,224,070
G
Adipoq
adiponectin, C1Q and collagen domain containing
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16155579
NCBI chrNW_004936578:3,168,599...3,179,369
Ensembl chrNW_004936578:3,168,331...3,171,928
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Adrb1
adrenoceptor beta 1
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:10900253 PMID:17201736
RGD:5129149
NCBI chrNW_004936486:4,400,467...4,401,588
Ensembl chrNW_004936486:4,399,915...4,403,149
G
Adrb2
adrenoceptor beta 2
ISO
RGD
PMID:16269402
RGD:1598746
NCBI chrNW_004936504:5,985,407...5,987,453
Ensembl chrNW_004936504:5,985,960...5,987,210
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Ager
advanced glycosylation end-product specific receptor
ISO
protein:increased expression:heart (rat)
RGD
PMID:16505177
RGD:1625342
NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147
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Agl
amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase
ISO
RGD
PMID:9281456
RGD:1598779
NCBI chrNW_004937224:23,225...32,639
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Agt
angiotensinogen
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:2535056 PMID:19166939
NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261
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Agtr1
angiotensin II receptor type 1
ISO
protein:increased expression:myocardium
RGD
PMID:21078800
RGD:5129194
NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985
G
Ahr
aryl hydrocarbon receptor
treatment
ISO
RGD
PMID:35788946
RGD:401793705
NCBI chrNW_004936546:3,737,908...3,783,492
Ensembl chrNW_004936546:3,737,851...3,783,588
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Aifm1
apoptosis inducing factor mitochondria associated 1
ISO
protein:decreased expression:mitochondrion:
RGD
PMID:23685150
RGD:10053560
NCBI chrNW_004936479:1,441,508...1,477,133
Ensembl chrNW_004936479:1,441,437...1,478,107
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Akt1
AKT serine/threonine kinase 1
ISO
protein:increased phosphorylation:heart left ventricle
RGD
PMID:20217242
RGD:5509104
NCBI chrNW_004936621:620,163...639,115
Ensembl chrNW_004936621:620,074...639,093
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Akt2
AKT serine/threonine kinase 2
ISO
RGD
PMID:16418318
RGD:2313347
NCBI chrNW_004936661:2,652,568...2,694,039
Ensembl chrNW_004936661:2,652,566...2,694,086
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Aldh2
aldehyde dehydrogenase 2 family member
ISO
RGD
PMID:23468836
RGD:7241598
NCBI chrNW_004936558:4,362,693...4,387,705
Ensembl chrNW_004936558:4,362,654...4,390,414
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Alox5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:20011686
RGD:2317527
NCBI chrNW_004936554:7,807,914...7,848,691
Ensembl chrNW_004936554:7,808,355...7,867,931
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Angpt2
angiopoietin 2
ISO
mRNA, protein:increased expression:myocardium (rat)
RGD
PMID:12737621
RGD:1601505
NCBI chrNW_004936615:4,472,261...4,524,537
Ensembl chrNW_004936615:4,472,247...4,524,556
G
Ank1
ankyrin 1
ISO
RGD
PMID:9378703
RGD:1599110
NCBI chrNW_004936785:738,323...944,734
Ensembl chrNW_004936785:738,317...942,381
G
Ank2
ankyrin 2
ISO
RGD
PMID:9378703
RGD:1599110
NCBI chrNW_004936563:3,520,195...4,170,716
Ensembl chrNW_004936563:3,520,193...4,171,362
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Ankrd1
ankyrin repeat domain 1
ISO
protein:decreased expression:myocardium
RGD
PMID:19299913
RGD:5133278
NCBI chrNW_004936601:3,502,844...3,510,919
Ensembl chrNW_004936601:3,502,844...3,511,003
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Anxa1
annexin A1
treatment
ISO
protein:increased expression:heart, leukocyte
RGD
PMID:11641252 PMID:22924634
RGD:2306910 RGD:7421655
NCBI chrNW_004936503:9,124,314...9,142,372
Ensembl chrNW_004936503:9,124,264...9,142,413
G
Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
ISO
protein:altered localization:cytoplasm
RGD
PMID:17602955
RGD:2315672
NCBI chrNW_004936877:666,545...669,351
Ensembl chrNW_004936877:666,523...669,338
G
Arrb2
arrestin beta 2
ISO
RGD
PMID:29016703
RGD:13506827
NCBI chrNW_004936677:3,173,054...3,181,475
Ensembl chrNW_004936677:3,172,925...3,181,520
G
Atf3
activating transcription factor 3
ISO
RGD
PMID:11485922
RGD:7327201
NCBI chrNW_004936557:909,302...922,619
Ensembl chrNW_004936557:908,318...922,624
G
Atp1a1
ATPase Na+/K+ transporting subunit alpha 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29702141
NCBI chrNW_004936627:1,555,151...1,584,370
Ensembl chrNW_004936627:1,554,873...1,584,638
G
Atp2a1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
ISO
RGD
PMID:17630344
RGD:13782075
NCBI chrNW_004936501:11,818,301...11,836,221
Ensembl chrNW_004936501:11,816,585...11,836,231
G
Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:10734148 PMID:28637456
RGD:13782080
NCBI chrNW_004936558:3,300,941...3,357,595
Ensembl chrNW_004936558:3,300,941...3,357,941
G
Atp5f1d
ATP synthase F1 subunit delta
treatment
ISO
protein:decreased expression:myocardium (rat)
RGD
PMID:25305180 PMID:26109848
RGD:13792666 RGD:13792676
NCBI chrNW_004936588:612,255...614,894
Ensembl chrNW_004936588:611,725...617,782
G
Bad
BCL2 associated agonist of cell death
treatment
ISO
protein:increased expression, decreased serine phosphorylation:heart
RGD
PMID:15339931 PMID:23364609
RGD:10053674 RGD:2292700
NCBI chrNW_004936599:4,924,349...4,933,683
Ensembl chrNW_004936599:4,924,789...4,933,368
G
Bax
BCL2 associated X, apoptosis regulator
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:20026869 PMID:21223820 PMID:25547710 PMID:31583047
RGD:10054103 RGD:13782178 RGD:155230831
NCBI chrNW_004936664:2,968,103...2,973,652
Ensembl chrNW_004936664:2,967,865...2,973,820
G
Bcl2
BCL2 apoptosis regulator
treatment
ISO
RGD
PMID:16289365 PMID:20821058 PMID:23364609 PMID:31583047
RGD:10053674 RGD:11561911 RGD:155230831 RGD:1599484
NCBI chrNW_004936497:2,209,136...2,373,580
Ensembl chrNW_004936497:2,210,334...2,210,921
G
Bcl2l1
BCL2 like 1
treatment
ISO
RGD
PMID:12668130
RGD:11035287
NCBI chrNW_004936485:18,654,046...18,707,324
G
Becn1
beclin 1
treatment
ISO
RGD
PMID:20812860 PMID:20821058
RGD:11561911 RGD:11561944
NCBI chrNW_004936490:17,518,100...17,531,126
Ensembl chrNW_004936490:17,517,751...17,531,151
G
Bid
BH3 interacting domain death agonist
ISO
protein:increased cleavage:heart:
RGD
PMID:11934844 PMID:19940077
RGD:13782263 RGD:2317561
NCBI chrNW_004936807:708,340...750,127
Ensembl chrNW_004936807:708,276...750,093
G
Blk
BLK proto-oncogene, Src family tyrosine kinase
ISO
mRNA:increased expression:left ventricle (rat)
RGD
PMID:17562528
RGD:1642307
NCBI chrNW_004936675:3,228,982...3,246,617
Ensembl chrNW_004936675:3,229,154...3,246,292
G
Bnip3
BCL2 interacting protein 3
treatment
ISO
protein:decreased expression:myocardium (human)
RGD
PMID:16645637 PMID:28661226
RGD:11561983 RGD:155260328
NCBI chrNW_004936486:18,449,371...18,460,435
Ensembl chrNW_004936486:18,448,494...18,455,927
G
Brd4
bromodomain containing 4
ISO
mRNA,protein:increased expression:heart
RGD
PMID:33982231
RGD:155883171
NCBI chrNW_004936596:5,176,682...5,246,102
Ensembl chrNW_004936596:5,177,147...5,246,518
G
Btg2
BTG anti-proliferation factor 2
ISO
mRNA:increased expression:heart
RGD
PMID:12909328
RGD:2289075
NCBI chrNW_004936567:1,310,525...1,314,469
Ensembl chrNW_004936567:1,309,658...1,314,515
G
C3
complement C3
ISO
protein:increased expression:myocardium
RGD
PMID:11560858
RGD:1582136
NCBI chrNW_004936588:3,985,732...4,023,221
G
C5
complement C5
treatment
ISO
RGD
PMID:9631876 PMID:23067403
RGD:1600666 RGD:7411626
NCBI chrNW_004936487:9,391,774...9,474,168
Ensembl chrNW_004936487:9,391,804...9,474,159
G
Casp3
caspase 3
ameliorates treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:14998631 PMID:18470603 PMID:29538428 PMID:30259997
RGD:13782276 RGD:2293314 RGD:329337366
NCBI chrNW_004936554:4,571,072...4,593,765
G
Casp7
caspase 7
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:14998631 PMID:29538428
RGD:13782276
NCBI chrNW_004936486:4,082,664...4,114,942
Ensembl chrNW_004936486:4,088,372...4,114,955
G
Casp8
caspase 8
ISO
CTD Direct Evidence: marker/mechanism protein:increased activity:cardiomyocyte
CTD RGD
PMID:11934844 PMID:14998631
RGD:13782263
NCBI chrNW_004936726:554,627...596,334
Ensembl chrNW_004936726:554,758...595,922
G
Casp9
caspase 9
treatment ameliorates
ISO
CTD Direct Evidence: marker/mechanism protein:increased activity:cardiomyocyte,endothelial cell
RGD CTD
PMID:11934844 PMID:14998631 PMID:29538428 PMID:30259997
RGD:13782263 RGD:13782276 RGD:329337366
NCBI chrNW_004936474:3,178,097...3,196,130
G
Casr
calcium sensing receptor
ISO
protein:increased expression:ventricular myocardium (rat)
RGD
PMID:21766206
RGD:7205698
NCBI chrNW_004936536:8,574,064...8,599,446
Ensembl chrNW_004936536:8,574,064...8,599,454
G
Cast
calpastatin
ameliorates
ISO
human transcript overexpression in rat model
RGD
PMID:12482022 PMID:14519437
RGD:405101692 RGD:5683872
NCBI chrNW_004936523:6,688,153...6,798,184
Ensembl chrNW_004936523:6,686,519...6,798,321
G
Cat
catalase
ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:11510883 PMID:21600015
RGD:1581149
NCBI chrNW_004936533:3,601,270...3,637,128
Ensembl chrNW_004936533:3,600,955...3,637,422
G
Cbl
Cbl proto-oncogene
severity
ISO
RGD
PMID:24583314
RGD:11251947
NCBI chrNW_004936542:4,136,389...4,235,746
Ensembl chrNW_004936542:4,136,511...4,228,288
G
Cflar
CASP8 and FADD like apoptosis regulator
treatment
ISO
RGD
PMID:18466417
RGD:11341714
NCBI chrNW_004936726:381,888...425,565
Ensembl chrNW_004936726:381,835...423,311
G
Cnr1
cannabinoid receptor 1
ISO
RGD
PMID:18771032
RGD:2316217
NCBI chrNW_004936510:3,779,930...3,806,615
Ensembl chrNW_004936510:3,781,210...3,802,693
G
Cnr2
cannabinoid receptor 2
ISO
RGD
PMID:17950273
RGD:2316224
NCBI chrNW_004936474:9,019,044...9,020,110
Ensembl chrNW_004936474:9,019,067...9,020,110
G
Cobll1
cordon-bleu WH2 repeat protein like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34355838
NCBI chrNW_004936469:14,424,538...14,575,228
Ensembl chrNW_004936469:14,424,145...14,575,121
G
Crebbp
CREB binding protein
treatment
ISO
RGD
PMID:24338162
RGD:153352322
NCBI chrNW_004936694:552,447...663,237
Ensembl chrNW_004936694:553,753...663,617
G
Crp
C-reactive protein
ISO
protein:increased expression:serum
RGD
PMID:21122204
RGD:5128547
NCBI chrNW_004936740:885,855...888,854
Ensembl chrNW_004936740:883,272...890,606
G
Cx3cr1
C-X3-C motif chemokine receptor 1
ISO
protein:decreased expression:blood, monocyte
RGD
PMID:15786508
RGD:4892017
NCBI chrNW_004936473:28,508,726...28,535,640
Ensembl chrNW_004936473:28,510,523...28,535,627
G
Cybb
cytochrome b-245 beta chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19207477
NCBI chrNW_004936502:4,631,750...4,676,686
Ensembl chrNW_004936502:4,635,149...4,676,904
G
Diablo
diablo IAP-binding mitochondrial protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14998631
NCBI chrNW_004936558:2,260,459...2,268,941
Ensembl chrNW_004936558:2,260,359...2,268,941
G
Dnm1l
dynamin 1 like
ameliorates
ISO
RGD
PMID:30259997
RGD:329337366
NCBI chrNW_004936607:3,576,357...3,632,423
Ensembl chrNW_004936607:3,576,392...3,632,554
G
Ece1
endothelin converting enzyme 1
ISO
RGD
PMID:12193087 PMID:18586023
RGD:4892580 RGD:7244160
NCBI chrNW_004936474:7,034,134...7,083,005
Ensembl chrNW_004936474:7,034,134...7,083,005
G
Edn1
endothelin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:15642760 PMID:16700825 PMID:18586023
RGD:4892580
NCBI chrNW_004936534:885,489...892,292
Ensembl chrNW_004936534:885,287...891,772
G
Ednra
endothelin receptor type A
ISO
RGD
PMID:18586023
RGD:4892580
NCBI chrNW_004936535:1,950,117...2,005,786
Ensembl chrNW_004936535:1,949,941...2,005,910
G
Ednrb
endothelin receptor type B
ISO
RGD
PMID:21048781
RGD:4892332
NCBI chrNW_004936511:3,446,864...3,478,434
Ensembl chrNW_004936511:3,446,839...3,478,434
G
Egln1
egl-9 family hypoxia inducible factor 1
susceptibility
ISO
RGD
PMID:20185832
RGD:11251775
NCBI chrNW_004936484:19,343,770...19,386,087
G
Ephx2
epoxide hydrolase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19834332
NCBI chrNW_004936675:350,357...392,919
Ensembl chrNW_004936675:350,342...392,551
G
Esr1
estrogen receptor 1
ISO
RGD
PMID:18314151
RGD:4892299
NCBI chrNW_004936489:4,616,839...4,887,179
Ensembl chrNW_004936489:4,614,754...4,887,171
G
Esr2
estrogen receptor 2
ISO
RGD
PMID:18656630
RGD:5508820
NCBI chrNW_004936495:7,956,168...8,018,356
Ensembl chrNW_004936495:7,956,766...8,004,357
G
Fadd
Fas associated via death domain
treatment
ISO
RGD
PMID:26038570 PMID:26948086
RGD:11341801 RGD:13792504
NCBI chrNW_004936599:633,501...639,412
Ensembl chrNW_004936599:633,330...639,456
G
Fas
Fas cell surface death receptor
treatment
ISO
RGD
PMID:21316771
RGD:8686424
NCBI chrNW_004936735:209,369...234,582
G
Fis1
fission, mitochondrial 1
ameliorates
ISO
RGD
PMID:30259997
RGD:329337366
NCBI chrNW_004936543:1,112,746...1,116,521
Ensembl chrNW_004936543:1,112,742...1,116,518
G
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
treatment
ISO
RGD
PMID:27129213
RGD:11574725
NCBI chrNW_004936709:1,243,149...1,247,782
Ensembl chrNW_004936709:1,243,147...1,247,903
G
Gcg
glucagon
treatment
ISO
RGD
PMID:24125539
RGD:10402369
NCBI chrNW_004936469:16,906,658...16,916,045
Ensembl chrNW_004936469:16,906,658...16,916,045
G
Gdf11
growth differentiation factor 11
ISO
mRNA, protein:decreased expression:heart (mouse)
RGD
PMID:30765322
RGD:329849112
NCBI chrNW_004936646:215,101...227,296
Ensembl chrNW_004936646:216,946...224,321
G
Gja1
gap junction protein alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17445419
NCBI chrNW_004936658:3,920,043...3,932,987
Ensembl chrNW_004936658:3,920,043...3,932,987
G
Glrx
glutaredoxin
ISO
mRNA:decreased expression:heart:
RGD
PMID:18163565
RGD:2306160
NCBI chrNW_004936523:7,535,650...7,544,339
Ensembl chrNW_004936523:7,535,857...7,541,864
G
Gpx3
glutathione peroxidase 3
ISO
RGD
PMID:11043918
RGD:401827843
NCBI chrNW_004936647:3,904,787...3,914,223
Ensembl chrNW_004936647:3,906,113...3,913,498
G
Grk2
G protein-coupled receptor kinase 2
severity treatment susceptibility
ISO
associated with Diabetes Mellitus, Experimental protein:increased expression:heart, mitochondrion (mouse) associated with Hypertension
RGD
PMID:23467820 PMID:24170934 PMID:27296507 PMID:27601479 PMID:27865836
RGD:13513990 RGD:13513993 RGD:13513995 RGD:13792704 RGD:13792779
NCBI chrNW_004936599:2,437,061...2,456,141
Ensembl chrNW_004936599:2,437,032...2,456,147
G
Gsk3b
glycogen synthase kinase 3 beta
treatment
ISO
RGD
PMID:20217242 PMID:26918336 PMID:29978610
RGD:13792725 RGD:13792772 RGD:5509104
NCBI chrNW_004936536:6,730,070...6,893,818
Ensembl chrNW_004936536:6,730,062...6,894,303
G
Gsr
glutathione-disulfide reductase
treatment
ISO
RGD
PMID:24769323
RGD:10401892
NCBI chrNW_004936792:531,076...579,083
Ensembl chrNW_004936792:531,756...579,166
G
Hdac3
histone deacetylase 3
ameliorates
ISO
RGD
PMID:33982231
RGD:155883171
NCBI chrNW_004936504:12,530,546...12,546,556
Ensembl chrNW_004936504:12,530,528...12,546,556
G
Hif1a
hypoxia inducible factor 1 subunit alpha
treatment
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:myocardium mRNA:increased expression:heart
CTD RGD
PMID:12189448 PMID:18549825 PMID:19727523 PMID:20170615 PMID:22050707
RGD:1626327 RGD:5147885 RGD:9068872
NCBI chrNW_004936495:5,770,988...5,816,157
Ensembl chrNW_004936495:5,770,669...5,816,157
G
Hmgb1
high mobility group box 1
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:19540007 PMID:21113057 PMID:23531454
RGD:10402066 RGD:10402170
NCBI chrNW_004936472:25,236,728...25,246,585
Ensembl chrNW_004936472:25,236,728...25,246,580
G
Hmox1
heme oxygenase 1
treatment
ISO
RGD
PMID:12709584 PMID:22179023 PMID:23921302
RGD:10755573 RGD:10755585 RGD:1598392
NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311
G
Hrh2
histamine receptor H2
susceptibility
ISO
RGD
PMID:23467745
RGD:9685524
NCBI chrNW_004936609:624,446...664,049
Ensembl chrNW_004936609:622,311...664,084
G
Hrh3
histamine receptor H3
ISO
RGD
PMID:15076218
RGD:1626433
NCBI chrNW_004936514:9,862,104...9,865,614
Ensembl chrNW_004936514:9,862,523...9,873,159
G
Hsf1
heat shock transcription factor 1
ISO
RGD
PMID:22426029
RGD:10402789
NCBI chrNW_004936470:7,927,734...7,950,805
Ensembl chrNW_004936470:7,928,095...7,933,337
G
Hspa5
heat shock protein family A (Hsp70) member 5
treatment
ISO
RGD
PMID:24129401 PMID:25547710
RGD:11354962 RGD:13782178
NCBI chrNW_004936487:13,348,465...13,352,717
Ensembl chrNW_004936487:13,348,465...13,352,717
G
Htra2
HtrA serine peptidase 2
ISO
protein:increased expression:myocardium, cytosol (mouse)
RGD
PMID:15611365
RGD:5688376
NCBI chrNW_004936556:741,718...746,016
Ensembl chrNW_004936556:741,718...749,090
G
Icam1
intercellular adhesion molecule 1
ISO
protein:increased expression:heart (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12087064 PMID:20851484
RGD:4145348
NCBI chrNW_004936659:616,570...627,172
Ensembl chrNW_004936659:616,752...627,174
G
Il10
interleukin 10
treatment
ISO
protein:increased expression:plasma
RGD
PMID:19275881 PMID:23840272
RGD:2311056 RGD:7365001
NCBI chrNW_004936557:5,834,874...5,838,502
Ensembl chrNW_004936557:5,834,874...5,838,502
G
Il17a
interleukin 17A
treatment
ISO
RGD
PMID:22030025
RGD:9068944
NCBI chrNW_004936476:8,621,860...8,625,008
Ensembl chrNW_004936476:8,621,860...8,625,008
G
Il18
interleukin 18
ISO
RGD
PMID:19164288 PMID:19805173
RGD:4889400 RGD:4889578
NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189
G
Il18bp
interleukin 18 binding protein
ISO
mRNA:increased expression:heart
RGD
PMID:19164288 PMID:19805173
RGD:4889400 RGD:4889578
NCBI chrNW_004936498:1,353,569...1,358,312
Ensembl chrNW_004936498:1,355,749...1,361,117
G
Il18rap
interleukin 18 receptor accessory protein
ISO
RGD
PMID:19164288
RGD:4889578
NCBI chrNW_004936713:1,087,884...1,115,512
G
Il1a
interleukin 1 alpha
treatment
ISO
RGD
PMID:7622355 PMID:8576926
RGD:7794741 RGD:7794764
NCBI chrNW_004936783:1,210,715...1,218,315
Ensembl chrNW_004936783:1,210,809...1,218,315
G
Il1b
interleukin 1 beta
treatment
ISO
mRNA:increased expression:heart
RGD
PMID:17134725 PMID:31583047
RGD:155230831 RGD:1626628
NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165
G
Il1rl2
interleukin 1 receptor like 2
ISO
compared to Wild Type in cardiopulmonary bypass model
RGD
PMID:32048631
RGD:126925167
NCBI chrNW_004936713:893,020...932,406
Ensembl chrNW_004936713:893,769...930,889
G
Il1rn
interleukin 1 receptor antagonist
ISO
rat model treated with human protein
RGD
PMID:22649318
RGD:7174360
NCBI chrNW_004936783:1,447,158...1,466,331
Ensembl chrNW_004936783:1,447,106...1,466,340
G
Il36rn
interleukin 36 receptor antagonist
ISO
RGD
PMID:32048631
RGD:126925167
NCBI chrNW_004936783:1,396,720...1,404,416
Ensembl chrNW_004936783:1,401,482...1,404,416
G
Il6
interleukin 6
treatment
ISO
RGD
PMID:27087891 PMID:31583047
RGD:11062149 RGD:155230831
NCBI chrNW_004936549:7,015,595...7,016,246
G
Il6r
interleukin 6 receptor
ISO
RGD
PMID:16056242
RGD:1625435
NCBI chrNW_004936580:4,055,438...4,081,876
Ensembl chrNW_004936580:4,057,771...4,081,885
G
Inhba
inhibin subunit beta A
ISO
mRNA, protein:increased expression:heart (mouse)
RGD
PMID:30765322
RGD:329849112
NCBI chrNW_004936478:16,878,725...16,884,065
G
Irak1
interleukin 1 receptor associated kinase 1
ISO
protein:increased activity:ventricle myocardium (rat)
RGD
PMID:15793310
RGD:1579809
NCBI chrNW_004936809:891,407...900,311
Ensembl chrNW_004936809:890,717...900,326
G
Irf9
interferon regulatory factor 9
ameliorates exacerbates
ISO
protein:increased expression:left ventricular free wall
RGD
PMID:25150882
RGD:125093742
NCBI chrNW_004936722:380,193...385,887
Ensembl chrNW_004936722:380,572...384,372
G
Jak2
Janus kinase 2
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:23747931 PMID:23796350
RGD:10403071 RGD:8694332
NCBI chrNW_004936503:111,722...243,627
Ensembl chrNW_004936503:110,963...241,867
G
Kcnj11
potassium inwardly rectifying channel subfamily J member 11
ISO
RGD
PMID:17906066
RGD:7297046
NCBI chrNW_004936528:1,685,015...1,688,220
Ensembl chrNW_004936528:1,685,924...1,687,096
G
Kcnj8
potassium inwardly rectifying channel subfamily J member 8
ISO
RGD
PMID:12234964
RGD:729109
NCBI chrNW_004936548:5,125,583...5,132,490
Ensembl chrNW_004936548:5,125,555...5,133,078
G
Kng1
kininogen 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:2535056 PMID:7856280
NCBI chrNW_004936578:3,255,335...3,281,296
Ensembl chrNW_004936578:3,253,749...3,281,296
G
Lep
leptin
ISO
RGD
PMID:21122204
RGD:5128547
NCBI chrNW_004936479:15,394,966...15,411,334
Ensembl chrNW_004936479:15,394,966...15,411,334
G
Lepr
leptin receptor
ISO
mRNA:altered expression:heart mRNA:decreased expression:heart
RGD
PMID:15284063 PMID:17134725
RGD:1626628 RGD:5129123
NCBI chrNW_004936591:5,771,371...5,846,177
Ensembl chrNW_004936591:5,774,326...5,836,444
G
LOC101956126
heat shock 70 kDa protein 1
treatment
ISO
RGD
PMID:20501665
RGD:10003160
NCBI chrNW_004936727:1,732,323...1,735,128
G
LOC101966907
histone H2AX
treatment
ISO
RGD
PMID:23108649
RGD:8693739
NCBI chrNW_004936542:4,046,930...4,049,017
Ensembl chrNW_004936542:4,047,915...4,048,346
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Lum
lumican
ISO
RGD
PMID:11348051
RGD:1582122
NCBI chrNW_004936507:7,847,761...7,855,311
Ensembl chrNW_004936507:7,846,681...7,855,455
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Map1lc3a
microtubule associated protein 1 light chain 3 alpha
treatment
ISO
protein:increased expression:heart
RGD
PMID:20812860 PMID:20821058
RGD:11561911 RGD:11561944
NCBI chrNW_004936561:6,104,748...6,106,348
Ensembl chrNW_004936561:6,104,742...6,106,699
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Map3k5
mitogen-activated protein kinase kinase kinase 5
treatment
ISO
RGD
PMID:31583047
RGD:155230831
NCBI chrNW_004936560:3,988,696...4,197,953
Ensembl chrNW_004936560:3,989,420...4,197,501
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Mapk1
mitogen-activated protein kinase 1
treatment
ISO
RGD
PMID:15653762 PMID:25345742
RGD:13800900 RGD:1582282
NCBI chrNW_004936619:1,889,841...1,932,646
Ensembl chrNW_004936619:1,889,708...1,932,646
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Mapk14
mitogen-activated protein kinase 14
ISO
RGD
PMID:14749328
RGD:7495840
NCBI chrNW_004936476:23,237,762...23,310,211
Ensembl chrNW_004936476:23,237,277...23,310,232
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Mapk3
mitogen-activated protein kinase 3
treatment
ISO
RGD
PMID:25345742 PMID:28814571 PMID:29741915
RGD:13800564 RGD:13800874 RGD:13800900
NCBI chrNW_004936501:12,342,670...12,390,650
Ensembl chrNW_004936501:12,384,804...12,392,180
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Mapk8
mitogen-activated protein kinase 8
treatment
ISO
RGD
PMID:12883833 PMID:15309413 PMID:31583047
RGD:155230831 RGD:1582311 RGD:1582312
NCBI chrNW_004936728:1,775,746...1,893,895
Ensembl chrNW_004936728:1,775,641...1,893,907
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Mb
myoglobin
treatment
ISO
RGD
PMID:11972171 PMID:15132981 PMID:31455109
RGD:1582385 RGD:1582431 RGD:487982219
NCBI chrNW_004936492:4,890,871...4,897,665
Ensembl chrNW_004936492:4,890,871...4,897,665
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Mdm2
MDM2 proto-oncogene
ISO
protein:increased serine phosphorylation:heart ventricle (rat)
RGD
PMID:14644432
RGD:2317401
NCBI chrNW_004936545:6,709,903...6,732,334
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Mfn2
mitofusin 2
treatment
ISO
RGD
PMID:24721408
RGD:13204835
NCBI chrNW_004936474:767,754...795,258
Ensembl chrNW_004936474:767,671...796,556
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Mki67
marker of proliferation Ki-67
ISO
RGD
PMID:22405128
RGD:6483543
NCBI chrNW_004936486:15,561,327...15,587,109
G
Mmp1
matrix metallopeptidase 1
ISO
RGD
PMID:12892382 PMID:17996137
RGD:1582539 RGD:7207397
NCBI chrNW_004936551:5,167,909...5,175,149
Ensembl chrNW_004936551:5,168,044...5,174,857
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Mmp2
matrix metallopeptidase 2
treatment
ISO
RGD
PMID:16699069 PMID:23889688
RGD:1582614 RGD:8657084
NCBI chrNW_004936475:7,801,356...7,825,831
Ensembl chrNW_004936475:7,801,277...7,825,851
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Mstn
myostatin
ISO
mRNA, protein:increased expression:heart (mouse)
RGD
PMID:30765322
RGD:329849112
NCBI chrNW_004936506:7,988,879...7,996,260
Ensembl chrNW_004936506:7,988,718...7,996,971
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Myd88
MYD88 innate immune signal transduction adaptor
ISO
RGD
PMID:14962484
RGD:1302746
NCBI chrNW_004936473:27,672,237...27,676,339
Ensembl chrNW_004936473:27,671,797...27,676,372
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Ndufs1
NADH:ubiquinone oxidoreductase core subunit S1
treatment
ISO
RGD
PMID:21700931
RGD:13801200
NCBI chrNW_004936631:2,503,353...2,538,957
Ensembl chrNW_004936631:2,499,062...2,538,801
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Nfe2l1
NFE2 like bZIP transcription factor 1
treatment
ISO
RGD
PMID:20501665
RGD:10003160
NCBI chrNW_004936490:13,265,269...13,279,164
Ensembl chrNW_004936490:13,266,347...13,279,206
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Nfe2l2
NFE2 like bZIP transcription factor 2
ISO
RGD
PMID:24915518
RGD:10412738
NCBI chrNW_004936509:6,589,967...6,621,171
Ensembl chrNW_004936509:6,590,630...6,620,262
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Nfkbia
NFKB inhibitor alpha
treatment
ISO
RGD
PMID:19304943
RGD:10413871
NCBI chrNW_004936494:9,537,793...9,541,187
Ensembl chrNW_004936494:9,537,008...9,541,612
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Nos2
nitric oxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism|therapeutic mRNA:decreased expression:heart (rat)
CTD RGD
PMID:12003803 PMID:12087064 PMID:14990356 PMID:19207477 PMID:20828608 PMID:21844074 More...
RGD:5509098
NCBI chrNW_004936538:4,052,277...4,097,051
Ensembl chrNW_004936538:4,052,448...4,097,051
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Nos3
nitric oxide synthase 3
treatment
ISO
CTD Direct Evidence: therapeutic
RGD CTD
PMID:12354446 PMID:18390819 PMID:20828747 PMID:29274587 PMID:29299201
RGD:13503347 RGD:13504684 RGD:2292091 RGD:4891991
NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534
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Nox1
NADPH oxidase 1
ISO
mRNA:increased expression:heart
RGD
PMID:33658472
RGD:329955358
NCBI chrNW_004936584:6,023,960...6,040,041
Ensembl chrNW_004936584:6,024,008...6,039,866
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Nppb
natriuretic peptide B
ISO
RGD
PMID:21168723
RGD:5685663
NCBI chrNW_004936474:683,325...684,662
Ensembl chrNW_004936474:683,325...684,665
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Nppc
natriuretic peptide C
ISO
RGD
PMID:15337698
RGD:1580149
NCBI chrNW_004936525:5,092,675...5,099,344
Ensembl chrNW_004936525:5,092,635...5,099,331
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Npr3
natriuretic peptide receptor 3
ISO
RGD
PMID:15337698
RGD:1580149
NCBI chrNW_004936518:8,093,111...8,158,862
Ensembl chrNW_004936518:8,093,561...8,158,868
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Npy1r
neuropeptide Y receptor Y1
ISO
mRNA:decreased expression:heart left ventricle
RGD
PMID:17562528
RGD:1642307
NCBI chrNW_004936555:2,267,727...2,276,673
Ensembl chrNW_004936555:2,267,669...2,276,778
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Olr1
oxidized low density lipoprotein receptor 1
treatment
ISO
RGD
PMID:12384456
RGD:628368
NCBI chrNW_004936902:405,536...416,393
Ensembl chrNW_004936902:409,704...416,401
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Oprd1
opioid receptor delta 1
ISO
RGD
PMID:12136724
RGD:2316590
NCBI chrNW_004936474:12,860,293...12,902,389
Ensembl chrNW_004936474:12,860,293...12,903,466
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P2ry12
purinergic receptor P2Y12
ISO
RGD
PMID:20431845
RGD:6480645
NCBI chrNW_004936758:1,581,828...1,624,332
Ensembl chrNW_004936758:1,581,897...1,592,222
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Parp1
poly(ADP-ribose) polymerase 1
ISO
RGD
PMID:9670921 PMID:23598272
RGD:11073735 RGD:5683917
NCBI chrNW_004936526:3,102,468...3,147,601
Ensembl chrNW_004936526:3,102,039...3,147,642
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Pawr
pro-apoptotic WT1 regulator
treatment
ISO
RGD
PMID:18055876
RGD:9835369
NCBI chrNW_004936698:650,225...746,593
Ensembl chrNW_004936698:650,953...747,057
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Pdia3
protein disulfide isomerase family A member 3
ISO
RGD
PMID:12872233
RGD:1624250
NCBI chrNW_004936471:6,809,181...6,834,189
Ensembl chrNW_004936471:6,809,195...6,836,169
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Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
RGD
PMID:8989147
RGD:2311662
NCBI chrNW_004936541:4,873,459...4,919,787
Ensembl chrNW_004936541:4,873,182...4,937,500
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Phlda3
pleckstrin homology like domain family A member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34351043
NCBI chrNW_004936567:2,981,632...2,984,906
Ensembl chrNW_004936567:2,981,602...2,984,903
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Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
ISO
RGD
PMID:20179753
RGD:6482687
NCBI chrNW_004936479:17,084,006...17,112,264
Ensembl chrNW_004936479:17,084,920...17,112,258
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Plcd1
phospholipase C delta 1
ISO
protein:altered activity
RGD
PMID:12623065
RGD:1304368
NCBI chrNW_004936473:27,364,404...27,387,337
Ensembl chrNW_004936473:27,364,389...27,387,412
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Pld2
phospholipase D2
ISO
protein:altered activity:sarcolemma, sarcoplasmic reticulum, heart left ventricle
RGD
PMID:15752718
RGD:2299906
NCBI chrNW_004936677:2,870,664...2,883,545
Ensembl chrNW_004936677:2,870,660...2,883,567
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Pln
phospholamban
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:10734148 PMID:21934351
RGD:7327186
NCBI chrNW_004936658:1,443,626...1,453,770
Ensembl chrNW_004936658:1,443,795...1,453,839
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Ppara
peroxisome proliferator activated receptor alpha
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16411023
NCBI chrNW_004936629:3,672,445...3,725,645
Ensembl chrNW_004936629:3,672,460...3,725,626
G
Ppard
peroxisome proliferator activated receptor delta
ISO
RGD
PMID:19997057
RGD:2324876
NCBI chrNW_004936476:23,799,285...23,886,606
Ensembl chrNW_004936476:23,811,641...23,828,176
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Pparg
peroxisome proliferator activated receptor gamma
ISO
RGD
PMID:18562925
RGD:2301853
NCBI chrNW_004936602:1,230,907...1,368,588
Ensembl chrNW_004936602:1,230,907...1,304,743
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Ppargc1a
PPARG coactivator 1 alpha
treatment
ISO
RGD
PMID:19096023
RGD:10059669
NCBI chrNW_004936477:4,881,230...5,488,208
Ensembl chrNW_004936477:5,199,881...5,488,226
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Prkaa2
protein kinase AMP-activated catalytic subunit alpha 2
treatment
ISO
RGD
PMID:20501665
RGD:10003160
NCBI chrNW_004936522:4,872,360...4,939,873
Ensembl chrNW_004936522:4,875,046...4,939,879
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Prkcb
protein kinase C beta
ISO
RGD
PMID:15878997
RGD:1625520
NCBI chrNW_004936501:8,410,273...8,729,238
Ensembl chrNW_004936501:8,437,715...8,728,716
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Prkcd
protein kinase C delta
ISO
protein:decreased expression:heart
RGD
PMID:17322024
RGD:1642542
NCBI chrNW_004936473:3,892,625...3,923,467
Ensembl chrNW_004936473:3,892,366...3,923,515
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Prkd1
protein kinase D1
ameliorates
ISO
RGD
PMID:24345679
RGD:307727199
NCBI chrNW_004936494:4,469,092...4,601,183
Ensembl chrNW_004936494:4,469,089...4,601,214
G
Prkg1
protein kinase cGMP-dependent 1
treatment
ISO
RGD
PMID:18332860 PMID:19845676
RGD:7777120 RGD:7777130
NCBI chrNW_004936787:330,390...1,491,994
Ensembl chrNW_004936787:332,342...1,491,285
G
Procr
protein C receptor
treatment
ISO
RGD
PMID:26994471
RGD:13515126
NCBI chrNW_004936561:5,557,640...5,562,981
Ensembl chrNW_004936561:5,557,630...5,563,030
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Pten
phosphatase and tensin homolog
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:19038262 PMID:20951693
RGD:127285611
NCBI chrNW_004936735:1,252,414...1,338,318
Ensembl chrNW_004936735:1,252,414...1,338,323
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Ptger3
prostaglandin E receptor 3
treatment
ISO
RGD
PMID:10193764
RGD:10043342
NCBI chrNW_004936591:1,174,364...1,250,233
Ensembl chrNW_004936591:1,174,069...1,249,410
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
RGD
PMID:17660401
RGD:2300261
NCBI chrNW_004936481:3,821,564...3,828,086
G
Rap1a
RAP1A, member of RAS oncogene family
treatment
ISO
RGD
PMID:20501665
RGD:10003160
NCBI chrNW_004936690:275,840...363,752
Ensembl chrNW_004936690:315,752...366,413
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Rela
RELA proto-oncogene, NF-kB subunit
treatment
ISO
protein:altered localization:nucleus
RGD
PMID:18636044 PMID:31583047
RGD:155230831 RGD:2298773
NCBI chrNW_004936599:3,800,142...3,810,583
Ensembl chrNW_004936599:3,801,636...3,809,813
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Rhoa
ras homolog family member A
ISO
protein:altered localization:heart
RGD
PMID:17322412
RGD:1642967
NCBI chrNW_004936529:1,000,050...1,045,655
Ensembl chrNW_004936529:999,935...1,045,681
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Rnf41
ring finger protein 41
severity
ISO
RGD
PMID:21312039
RGD:401827146
NCBI chrNW_004936646:605,302...630,645
Ensembl chrNW_004936646:605,302...631,022
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Rnls
renalase, FAD dependent amine oxidase
ISO
RGD
PMID:21178975
RGD:7327174
NCBI chrNW_004936735:659,826...1,048,135
G
Selp
selectin P
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12087064 PMID:21146547
RGD:6480105
NCBI chrNW_004936481:17,076,660...17,112,501
Ensembl chrNW_004936481:17,076,536...17,107,963
G
Serpina3
serpin family A member 3
ISO
RGD
PMID:7562495
RGD:5147423
NCBI chrNW_004936846:174,411...182,053
Ensembl chrNW_004936846:174,233...182,203
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Serpine1
serpin family E member 1
treatment
ISO
RGD
PMID:26958805
RGD:11073621
NCBI chrNW_004936543:1,032,543...1,040,956
Ensembl chrNW_004936543:1,032,794...1,039,123
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Serping1
serpin family G member 1
treatment
ISO
RGD
PMID:16942749
RGD:8661647
NCBI chrNW_004936581:4,911,403...4,924,484
Ensembl chrNW_004936581:4,908,458...4,924,645
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Sfrp2
secreted frizzled related protein 2
ISO
RGD
PMID:19109969
RGD:4107088
NCBI chrNW_004936576:604,174...612,440
Ensembl chrNW_004936576:604,069...613,021
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Sh2b3
SH2B adaptor protein 3
ISO
RGD
PMID:25628389
RGD:12904914
NCBI chrNW_004936558:4,103,898...4,126,883
Ensembl chrNW_004936558:4,104,534...4,123,869
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Shh
sonic hedgehog signaling molecule
ISO
protein:increased expression:heart
RGD
PMID:18228117
RGD:2306299
NCBI chrNW_004936527:10,033,095...10,042,713
Ensembl chrNW_004936527:10,033,299...10,042,599
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Sirt1
sirtuin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21060073
NCBI chrNW_004936521:10,296,097...10,316,673
Ensembl chrNW_004936521:10,296,097...10,322,215
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Slc25a4
solute carrier family 25 member 4
treatment
ISO
RGD
PMID:24126566
RGD:9681554
NCBI chrNW_004936554:4,130,461...4,135,046
Ensembl chrNW_004936554:4,130,459...4,135,044
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Slc2a1
solute carrier family 2 member 1
ISO
RGD
PMID:10336852
RGD:12879857
NCBI chrNW_004936474:24,205,878...24,236,611
Ensembl chrNW_004936474:24,206,644...24,236,713
G
Slc2a4
solute carrier family 2 member 4
ISO
RGD
PMID:10336852
RGD:12879857
NCBI chrNW_004936595:567,267...574,051
Ensembl chrNW_004936595:567,219...574,059
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Slc8a1
solute carrier family 8 member A1
ISO
CTD Direct Evidence: marker/mechanism protein:increased activity:cardiac muscle cell
CTD RGD
PMID:15215644 PMID:17267548 PMID:17822695
RGD:1642716 RGD:1642729
NCBI chrNW_004936508:10,894,918...11,256,084
Ensembl chrNW_004936508:10,968,656...11,253,070
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Slc9a1
solute carrier family 9 member A1
ISO
RGD
PMID:22803959
RGD:6771238
NCBI chrNW_004936474:11,460,266...11,517,420
Ensembl chrNW_004936474:11,459,929...11,517,478
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Smad1
SMAD family member 1
ISO
RGD
PMID:15911698
RGD:1643233
NCBI chrNW_004936535:3,582,512...3,626,312
Ensembl chrNW_004936535:3,582,489...3,657,063
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Smad3
SMAD family member 3
treatment
ISO
RGD
PMID:22913380
RGD:12903950
NCBI chrNW_004936471:27,080,662...27,185,861
Ensembl chrNW_004936471:27,080,575...27,189,793
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Smad4
SMAD family member 4
treatment
ISO
RGD
PMID:22913380
RGD:12903950
NCBI chrNW_004936497:12,242,869...12,278,012
Ensembl chrNW_004936497:12,249,140...12,278,123
G
Sod1
superoxide dismutase 1
treatment
ISO
human protein in a rat model
RGD
PMID:12668130 PMID:19277497 PMID:23629152
RGD:11035287 RGD:8655884 RGD:8655965
NCBI chrNW_004936500:10,345,154...10,352,873
Ensembl chrNW_004936500:10,345,154...10,352,867
G
Sod2
superoxide dismutase 2
treatment
ISO
RGD
PMID:11864929 PMID:12668130
RGD:11035287 RGD:1581222
NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781
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Sord
sorbitol dehydrogenase
ISO
CTD Direct Evidence: marker/mechanism protein:increased activity:heart
CTD RGD
PMID:14525943 PMID:18549825
RGD:1601364
NCBI chrNW_004936471:7,760,097...7,805,475
Ensembl chrNW_004936471:7,760,052...7,795,671
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Spp1
secreted phosphoprotein 1
ISO
RGD
PMID:15165989
RGD:1581342
NCBI chrNW_004936905:148,956...156,023
Ensembl chrNW_004936905:148,945...156,079
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Stat1
signal transducer and activator of transcription 1
ISO
protein:increased phosphorylation:heart
RGD
PMID:16935931
RGD:1600091
NCBI chrNW_004936506:7,196,860...7,235,854
Ensembl chrNW_004936506:7,196,797...7,233,756
G
Stat3
signal transducer and activator of transcription 3
treatment
ISO
RGD
PMID:23796350
RGD:8694332
NCBI chrNW_004936490:17,119,189...17,178,402
Ensembl chrNW_004936490:17,117,290...17,178,402
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Tek
TEK receptor tyrosine kinase
ISO
mRNA, protein:increased expression:ventricle myocardium
RGD
PMID:12737621
RGD:1601505
NCBI chrNW_004936611:2,420,176...2,531,726
Ensembl chrNW_004936611:2,420,172...2,531,722
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Tfrc
transferrin receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18549825
NCBI chrNW_004936784:696,738...728,385
Ensembl chrNW_004936784:696,713...728,543
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Tgfb1
transforming growth factor beta 1
treatment
ISO
RGD
PMID:22913380
RGD:12903950
NCBI chrNW_004936661:3,742,080...3,758,266
Ensembl chrNW_004936661:3,742,066...3,758,272
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Thbs1
thrombospondin 1
ISO
mRNA:increased expression:heart
RGD
PMID:16179730
RGD:2317960
NCBI chrNW_004936471:3,064,466...3,081,125
Ensembl chrNW_004936471:3,064,422...3,081,949
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Timp4
TIMP metallopeptidase inhibitor 4
ISO
protein:increased expression:blood
RGD
PMID:12707244
RGD:2290461
NCBI chrNW_004936602:1,488,993...1,496,108
Ensembl chrNW_004936602:1,489,545...1,495,478
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Tlr2
toll like receptor 2
treatment
ISO
protein:increased expression:serum
RGD
PMID:19274437 PMID:22402367 PMID:32377693 PMID:32626996
RGD:2312688 RGD:597538502 RGD:597621676 RGD:597621678
NCBI chrNW_004936576:522,234...531,660
Ensembl chrNW_004936576:527,434...529,788
G
Tlr4
toll like receptor 4
ISO
protein:increased expression:serum
RGD
PMID:14962484 PMID:32626996
RGD:1302746 RGD:597621676
NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095
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Tnc
tenascin C
ISO
RGD
PMID:20554738
RGD:4889599
NCBI chrNW_004936487:4,172,263...4,256,780
Ensembl chrNW_004936487:4,172,886...4,233,126
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Tnf
tumor necrosis factor
treatment
ISO
protein:increased expression:serum, heart:
RGD
PMID:24157164 PMID:31583047
RGD:155230831 RGD:7387274
NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
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Tnni3
troponin I3, cardiac type
ameliorates
ISO
RGD
PMID:30259997
RGD:329337366
NCBI chrNW_004936886:437,754...440,925
Ensembl chrNW_004936886:437,754...440,458
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Tp53
tumor protein p53
ISO
protein:increased expression:heart
RGD
PMID:18317410
RGD:2290554
NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425
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Txn
thioredoxin
ISO
mRNA:decreased expression:heart
RGD
PMID:18045550
RGD:2306159
NCBI chrNW_004936559:2,811,786...2,822,528
Ensembl chrNW_004936559:2,811,782...2,822,528
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Txn2
thioredoxin 2
ISO
mRNA, protein:decreased expression:heart
RGD
PMID:18045550
RGD:2306159
NCBI chrNW_004936492:4,310,394...4,320,714
Ensembl chrNW_004936492:4,311,287...4,321,763
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Ucn
urocortin
ISO
RGD
PMID:15806110
RGD:1642783
NCBI chrNW_004936493:5,258,574...5,260,692
Ensembl chrNW_004936493:5,260,219...5,260,602
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Ucp2
uncoupling protein 2
ISO
mRNA:increased expression:myocardium
RGD
PMID:19526854
RGD:2313528
NCBI chrNW_004936498:3,059,700...3,066,112
Ensembl chrNW_004936498:3,059,297...3,066,197
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Ucp3
uncoupling protein 3
ISO
mRNA:increased expression:myocardium
RGD
PMID:19526854
RGD:2313528
NCBI chrNW_004936498:3,082,575...3,095,739
Ensembl chrNW_004936498:3,082,575...3,095,737
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Uts2
urotensin 2
ISO
RGD
PMID:17900760
RGD:2306836
NCBI chrNW_004936623:2,339,259...2,345,717
Ensembl chrNW_004936623:2,340,778...2,345,700
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Uts2r
urotensin 2 receptor
ISO
RGD
PMID:17900760
RGD:2306836
NCBI chrNW_004936923:24,952...31,083
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Vcam1
vascular cell adhesion molecule 1
ISO
protein:increased expression:heart
RGD
PMID:23052973
RGD:7207792
NCBI chrNW_004936748:785,491...802,791
Ensembl chrNW_004936748:785,455...803,048
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Vcan
versican
ISO
mRNA:increased expression:heart
RGD
PMID:16311904
RGD:1598497
NCBI chrNW_004936469:2,585,142...2,688,029
Ensembl chrNW_004936469:2,585,134...2,688,029
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Vdac1
voltage dependent anion channel 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25488258
NCBI chrNW_004936647:1,220,075...1,249,579
Ensembl chrNW_004936647:1,230,450...1,249,814
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Vdr
vitamin D receptor
ISO
mRNA,protein:increased expression, activity:heart:
RGD
PMID:25365634
RGD:13432076
NCBI chrNW_004936512:5,741,836...5,800,999
Ensembl chrNW_004936512:5,740,748...5,801,109
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Vegfa
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22050707
NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673
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Xdh
xanthine dehydrogenase
ISO
RGD
PMID:3162724
RGD:13209131
NCBI chrNW_004936493:1,762,814...1,824,501
Ensembl chrNW_004936493:1,762,869...1,823,238
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Xiap
X-linked inhibitor of apoptosis
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:14998631 PMID:20501665
RGD:10003160
NCBI chrNW_004936479:6,677,533...6,724,800
Ensembl chrNW_004936479:6,677,526...6,722,116
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16317512
NCBI chrNW_004936558:3,300,941...3,357,595
Ensembl chrNW_004936558:3,300,941...3,357,941
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Nos2
nitric oxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11927517
NCBI chrNW_004936538:4,052,277...4,097,051
Ensembl chrNW_004936538:4,052,448...4,097,051
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Pln
phospholamban
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16317512
NCBI chrNW_004936658:1,443,626...1,453,770
Ensembl chrNW_004936658:1,443,795...1,453,839
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11927517
NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
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Cdh5
cadherin 5
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16824628
NCBI chrNW_004936475:16,738,772...16,775,000
Ensembl chrNW_004936475:16,738,748...16,775,123
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Ctnnb1
catenin beta 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16824628
NCBI chrNW_004936473:29,999,542...30,034,610
Ensembl chrNW_004936473:29,999,562...30,038,293
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Jup
junction plakoglobin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16824628
NCBI chrNW_004936490:16,671,176...16,694,552
Ensembl chrNW_004936490:16,668,575...16,694,615
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Icam1
intercellular adhesion molecule 1
ISO
protein:increased expression:plasma
RGD
PMID:9415270
RGD:8547713
NCBI chrNW_004936659:616,570...627,172
Ensembl chrNW_004936659:616,752...627,174
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Kcnj8
potassium inwardly rectifying channel subfamily J member 8
ISO
RGD
PMID:11984590
RGD:1581700
NCBI chrNW_004936548:5,125,583...5,132,490
Ensembl chrNW_004936548:5,125,555...5,133,078
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Abcb1
ATP binding cassette subfamily B member 1
treatment
ISO
DNA:SNPs: :rs1045642,rs7779562(human)
RGD
PMID:25217066
RGD:14700903
NCBI chrNW_004936763:1,225,355...1,308,257
Ensembl chrNW_004936763:1,226,482...1,297,427
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Atp5mc2
ATP synthase membrane subunit c locus 2
severity
ISO
RGD
PMID:27441480
RGD:14696800
NCBI chrNW_004936512:10,908,915...10,918,445
Ensembl chrNW_004936512:10,908,881...10,918,445
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Ccn1
cellular communication network factor 1
sexual_dimorphism
ISO
protein:increased expression:blood serum (human)
RGD
PMID:34597881
RGD:329845519
NCBI chrNW_004936608:152,174...155,123
Ensembl chrNW_004936608:151,838...155,358
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Lgals3
galectin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29769800
NCBI chrNW_004936697:20,861...38,568
Ensembl chrNW_004936697:27,145...38,586
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F7
coagulation factor VII
ISO
protein:increased activity:plasma (human)
RGD
PMID:17357481
RGD:11049525
NCBI chrNW_004936472:505,751...515,375
Ensembl chrNW_004936472:505,751...514,339
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Mmp9
matrix metallopeptidase 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20981132
NCBI chrNW_004936514:7,038,240...7,045,873
Ensembl chrNW_004936514:7,037,639...7,045,793
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Rbp4
retinol binding protein 4
ISO
protein:increased expression:blood serum (human)
RGD
PMID:25142320
RGD:329845867
NCBI chrNW_004936601:1,401,215...1,410,195
Ensembl chrNW_004936601:1,402,691...1,410,208
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Tlr4
toll like receptor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20981132
NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095
G
Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20981132
NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all