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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:nephrotoxicity
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Accession:DOID:9006956 term browser browse the term
Definition:This is toxicity that causes injury to the kidney or damages its function. It is a poisonous effect of some substances, both toxic chemicals and medications.
Synonyms:exact_synonym: kidney toxicity;   renal toxicity
 xref: EFO:0011056


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nephrotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor ameliorates IMP RGD PMID:32112355 RGD:407419877 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G treatment IEP RGD PMID:37244046 RGD:329853759 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752 		JBrowse link
G Cacna1s calcium voltage-gated channel subunit alpha1 S treatment IEP RGD PMID:37244046 RGD:329853759 NCBI chr13:47,493,949...47,564,194
Ensembl chr13:47,493,949...47,564,318 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha treatment IEP RGD PMID:37244046 RGD:329853759 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 treatment IEP RGD PMID:37244046 RGD:329853759 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 treatment IEP RGD PMID:37244046 RGD:329853759 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Gatm glycine amidinotransferase IMP
HEP		 RGD PMID:15462098 PMID:19664912 RGD:329961309, RGD:329961312 NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129 		JBrowse link
G Gc GC, vitamin D binding protein treatment IEP RGD PMID:37244046 RGD:329853759 NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567 		JBrowse link
G Gpx3 glutathione peroxidase 3 treatment IEP RGD PMID:23662110 PMID:22115772 PMID:27412471 RGD:401827919, RGD:401827924, RGD:401827925 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 treatment IEP RGD PMID:37244046 RGD:329853759 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 treatment IEP RGD PMID:37244046 RGD:329853759 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Mir494 microRNA 494 ISO RGD PMID:25854542 RGD:156420140 NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793 		JBrowse link
G Nos2 nitric oxide synthase 2 treatment IEP RGD PMID:37244046 RGD:329853759 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ryr1 ryanodine receptor 1 treatment IEP RGD PMID:37244046 RGD:329853759 NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G S100a1 S100 calcium binding protein A1 treatment IEP RGD PMID:37244046 RGD:329853759 NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544 		JBrowse link
G S100b S100 calcium binding protein B treatment IEP RGD PMID:37244046 RGD:329853759 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 treatment IEP RGD PMID:37244046 RGD:329853759 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Vdr vitamin D receptor treatment IEP RGD PMID:37244046 RGD:329853759 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19050
    Pathological Conditions, Signs and Symptoms 13532
      Pathologic Processes 8240
        nephrotoxicity 18
Path 2
Term Annotations click to browse term
  disease 19050
    disease of anatomical entity 18384
      Urogenital Diseases 5275
        urinary system disease 2830
          kidney disease 2579
            nephrotoxicity 18
paths to the root