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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Diabetic Cardiomyopathies
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Accession:DOID:9006945 term browser browse the term
Definition:Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.
Synonyms:exact_synonym: Diabetic Cardiomyopathy
 xref: EFO:1001458;   MESH:D058065


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Diabetic Cardiomyopathies term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21742475 RGD:10046044 NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186 		JBrowse link
G Ace angiotensin I converting enzyme treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:22595130 RGD:9685456 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Ace2 angiotensin converting enzyme 2 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:22595130 RGD:9685456 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 IMP associated with type 2 diabetes mellitus RGD PMID:23226270 RGD:13831128 NCBI chr12:84,056,276...84,064,444
Ensembl chr12:84,056,264...84,065,145 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO associated with Diabetes Mellitus, Type2;mRNA, protein:decreased expression:heart, serum RGD PMID:24669271 RGD:8695938 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adipor1 adiponectin receptor 1 ISO associated with Diabetes Mellitus, Type2;mRNA, protein:decreased expression:heart, serum RGD PMID:24669271 RGD:8695938 NCBI chr 1:134,343,116...134,361,089
Ensembl chr 1:134,343,116...134,361,089 		JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment ISO associated with Diabetes Mellitus, Experimental; mRNA, protein:increased expression:heart (rat) RGD PMID:23251674 PMID:23251674 RGD:7244283, RGD:7244283 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:29353218 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15587404 PMID:16025228 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 ameliorates IEP RGD PMID:36044268 RGD:156430337 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Apoa1 apolipoprotein A-I ISO CTD Direct Evidence: therapeutic CTD PMID:18332268 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Atf6 activating transcription factor 6 ameliorates IEP RGD PMID:36044268 RGD:156430337 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340 		JBrowse link
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 ISO associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16685413 PMID:21441944 RGD:6771209 NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288 		JBrowse link
G Atp7a ATPase, copper transporting, alpha polypeptide treatment ISO RGD PMID:24927960 RGD:11341676 NCBI chr  X:105,070,830...105,171,766
Ensembl chr  X:105,070,882...105,168,532 		JBrowse link
G Bad BCL2-associated agonist of cell death treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21296063 RGD:10053697 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Bax BCL2-associated X protein ameliorates IEP RGD PMID:36044268 RGD:156430337 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 treatment ISO
IEP		 associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;protein:increased phosphorylation:myocardium (mouse)		 RGD PMID:21296063 PMID:21474815 RGD:10053697, RGD:11522727 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Brd4 bromodomain containing 4 ISO mRNA,protein:increased expression:heart RGD PMID:30483785 RGD:597830144 NCBI chr17:32,415,246...32,503,717
Ensembl chr17:32,415,248...32,503,696 		JBrowse link
G Casp12 caspase 12 treatment ISO associated with Experimental Diabetes Mellitus RGD PMID:26869403 RGD:13782171 NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032 		JBrowse link
G Casp3 caspase 3 treatment ISO RGD PMID:28992627 RGD:13782299 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 treatment ISO RGD PMID:28992627 RGD:13782299 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 treatment ISO RGD PMID:28992627 RGD:13782299 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Casq2 calsequestrin 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:21441944 RGD:6771209 NCBI chr 3:101,993,731...102,053,830
Ensembl chr 3:101,993,731...102,053,830 		JBrowse link
G Casr calcium-sensing receptor ISO protein:decreased expression:myocardium (rat) RGD PMID:22137362 RGD:7205677 NCBI chr16:36,310,947...36,382,605
Ensembl chr16:36,314,058...36,382,503 		JBrowse link
G Cfl1 cofilin 1, non-muscle treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:27576917 RGD:11568692 NCBI chr19:5,540,483...5,544,059
Ensembl chr19:5,540,483...5,545,229 		JBrowse link
G Ctnnb1 catenin beta 1 ISO mRNA,protein:increased expression:heart RGD PMID:25586361 RGD:13524855 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 ameliorates IEP RGD PMID:36044268 RGD:156430337 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO associated with Diabetes Mellitus, Experimental;mRNA:decreased expresssion:left ventricle myocardium RGD PMID:22285193 RGD:10449013 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 ISO associated with Diabetes Mellitus, Experimental;mRNA:decreased expresssion:left ventricle myocardium RGD PMID:22285193 RGD:10449013 NCBI chr 1:68,071,063...69,147,756
Ensembl chr 1:68,071,345...69,147,218 		JBrowse link
G H19 H19, imprinted maternally expressed transcript ameliorates ISO
IMP		 RGD PMID:27796346 PMID:36044268 PMID:27903964 RGD:156430325, RGD:156430337, RGD:156451660 NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,262...142,133,957 		JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:23853776 PMID:23453443 RGD:9586347, RGD:10412713 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 ameliorates IEP RGD PMID:36044268 RGD:156430337 NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373 		JBrowse link
G Hspa5 heat shock protein 5 ameliorates IEP RGD PMID:36044268 RGD:156430337 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:11375343 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igf2r insulin-like growth factor 2 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:36462176 NCBI chr17:12,901,293...12,988,593
Ensembl chr17:12,901,293...12,988,551 		JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:23843977 RGD:7247697 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Ins1 insulin I EXP CTD Direct Evidence: therapeutic CTD PMID:6225876 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ins2 insulin II ISO CTD Direct Evidence: therapeutic CTD PMID:20828608 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Klk1 kallikrein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:16129698 NCBI chr 7:43,874,784...43,879,046
Ensembl chr 7:43,874,784...43,879,042 		JBrowse link
G Lepr leptin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:35235096 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 ISO associated with type 2 diabetes mellitus;protein:decreased expression:myocardium of ventricle (rat) RGD PMID:22146585 RGD:155883162 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:25907942 RGD:13800893 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:25907942 RGD:13800893 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mir140 microRNA 140 ameliorates IEP RGD PMID:36044268 PMID:31078585 RGD:156430337, RGD:329347833 NCBI chr 8:108,277,876...108,277,945
Ensembl chr 8:108,277,876...108,277,945 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ameliorates IEP RGD PMID:36044268 RGD:156430337 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Myc myelocytomatosis oncogene ISO mRNA,protein:increased expression:heart RGD PMID:30483785 RGD:597830144 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Mylk2 myosin, light polypeptide kinase 2, skeletal muscle treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:9005973 RGD:1580244 NCBI chr 2:152,753,265...152,764,985
Ensembl chr 2:152,753,272...152,764,988 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 treatment
ameliorates		 ISO
IEP		 associated with Diabetes Mellitus, Experimental RGD PMID:23453443 PMID:23353773 PMID:36044268 RGD:10412713, RGD:10412721, RGD:156430337 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:29274332 RGD:13504685 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Notch1 notch 1 treatment ISO RGD PMID:32828943 RGD:405650202 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675 		JBrowse link
G Nppa natriuretic peptide type A treatment ISO associated with Diabetes Mellitus, Experimental
mRNA,protein:increased expression:heart		 RGD PMID:23497378 PMID:30483785 RGD:7297056, RGD:597830144 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536 		JBrowse link
G Nrg1 neuregulin 1 treatment ISO associated with Diabetes Mellitus, Experimental;protein:decreased expresssion:left ventricle myocardium RGD PMID:22285193 PMID:32828943 RGD:10449013, RGD:405650202 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ameliorates IEP RGD PMID:36044268 RGD:156430337 NCBI chr 3:32,451,203...32,520,256
Ensembl chr 3:32,451,820...32,522,635 		JBrowse link
G Pln phospholamban ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:heart left ventricle RGD PMID:22185592 RGD:7327207 NCBI chr10:53,213,782...53,222,095
Ensembl chr10:53,213,763...53,222,083 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO RGD PMID:19317897 RGD:5509944 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Ryr2 ryanodine receptor 2, cardiac ISO CTD Direct Evidence: marker/mechanism CTD PMID:16685413 NCBI chr13:11,567,985...12,121,831
Ensembl chr13:11,567,988...12,121,831 		JBrowse link
G Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 ISO CTD Direct Evidence: therapeutic CTD PMID:18945756 NCBI chr 8:46,660,205...46,664,099
Ensembl chr 8:46,659,834...46,664,321 		JBrowse link
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 treatment ISO RGD PMID:27058979 RGD:13628396 NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16980342 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Tert telomerase reverse transcriptase treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:21264070 RGD:11038677 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:17909696 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Xdh xanthine dehydrogenase treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:23843977 RGD:7247697 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16268
    disease of anatomical entity 15860
      cardiovascular system disease 4698
        heart disease 3369
          cardiomyopathy 1453
            Diabetic Cardiomyopathies 62
Path 2
Term Annotations click to browse term
  disease 16268
    Developmental Disease 14084
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 13140
        genetic disease 12834
          inherited metabolic disorder 6081
            carbohydrate metabolic disorder 2967
              glucose metabolism disease 1689
                diabetes mellitus 1459
                  Diabetes Complications 530
                    Diabetic Cardiomyopathies 62
paths to the root