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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Diabetic Cardiomyopathies
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Accession:DOID:9006945 term browser browse the term
Definition:Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.
Synonyms:exact_synonym: Diabetic Cardiomyopathy
 xref: EFO:1001458;   MESH:D058065


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Diabetic Cardiomyopathies term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:21742475 RGD:10046044 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Ace angiotensin I converting enzyme treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:22595130 RGD:9685456 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:22595130 RGD:9685456 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 ISO associated with type 2 diabetes mellitus RGD PMID:23226270 RGD:13831128 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing IEP associated with Diabetes Mellitus, Type2;mRNA, protein:decreased expression:heart, serum RGD PMID:24669271 RGD:8695938 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adipor1 adiponectin receptor 1 IEP associated with Diabetes Mellitus, Type2;mRNA, protein:decreased expression:heart, serum RGD PMID:24669271 RGD:8695938 NCBI chr13:48,411,438...48,431,251
Ensembl chr13:45,859,533...45,879,241 		JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment IEP
IDA		 associated with Diabetes Mellitus, Experimental; mRNA, protein:increased expression:heart (rat) RGD PMID:23251674 PMID:23251674 RGD:7244283, RGD:7244283 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:29353218 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15587404 PMID:16025228 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ameliorates ISO RGD PMID:36044268 RGD:156430337 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apoa1 apolipoprotein A1 ISO CTD Direct Evidence: therapeutic CTD PMID:18332268 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Atf6 activating transcription factor 6 ameliorates ISO RGD PMID:36044268 RGD:156430337 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 IEP
ISO		 associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16685413 PMID:21441944 RGD:6771209 NCBI chr12:39,733,519...39,782,942
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Atp7a ATPase copper transporting alpha treatment IMP RGD PMID:24927960 RGD:11341676 NCBI chr  X:75,159,635...75,267,094
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Bad BCL2-associated agonist of cell death treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:21296063 RGD:10053697 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator ameliorates ISO RGD PMID:36044268 RGD:156430337 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IDA
ISO		 associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;protein:increased phosphorylation:myocardium (mouse)		 RGD PMID:21296063 PMID:21474815 RGD:10053697, RGD:11522727 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp12 caspase 12 treatment IEP associated with Experimental Diabetes Mellitus RGD PMID:26869403 RGD:13782171 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 treatment IEP RGD PMID:28992627 RGD:13782299 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 treatment IEP RGD PMID:28992627 RGD:13782299 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 treatment IEP RGD PMID:28992627 RGD:13782299 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Casq2 calsequestrin 2 IDA associated with Diabetes Mellitus, Experimental RGD PMID:21441944 RGD:6771209 NCBI chr 2:192,214,556...192,270,821
Ensembl chr 2:189,525,960...189,582,267 		JBrowse link
G Casr calcium-sensing receptor IEP protein:decreased expression:myocardium (rat) RGD PMID:22137362 RGD:7205677 NCBI chr11:77,738,398...77,813,639
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Cfl1 cofilin 1 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:27576917 RGD:11568692 NCBI chr 1:212,227,124...212,230,656
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Ctnnb1 catenin beta 1 IEP mRNA,protein:increased expression:heart RGD PMID:25586361 RGD:13524855 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 ameliorates ISO RGD PMID:36044268 RGD:156430337 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 IEP associated with Diabetes Mellitus, Experimental;mRNA:decreased expresssion:left ventricle myocardium RGD PMID:22285193 RGD:10449013 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 IEP associated with Diabetes Mellitus, Experimental;mRNA:decreased expresssion:left ventricle myocardium RGD PMID:22285193 RGD:10449013 NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G H19 H19 imprinted maternally expressed transcript ameliorates IMP
ISO		 RGD PMID:27796346 PMID:36044268 PMID:27903964 RGD:156430325, RGD:156430337, RGD:156451660 NCBI chr 1:207,160,175...207,162,851
Ensembl chr 1:197,730,698...197,733,134 		JBrowse link
G Hmox1 heme oxygenase 1 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:23853776 PMID:23453443 RGD:9586347, RGD:10412713 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 ameliorates ISO RGD PMID:36044268 RGD:156430337 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ameliorates ISO RGD PMID:36044268 RGD:156430337 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:11375343 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf2r insulin-like growth factor 2 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:36462176 NCBI chr 1:50,526,878...50,615,265
Ensembl chr 1:47,979,109...48,067,501 		JBrowse link
G Il10 interleukin 10 treatment IDA RGD PMID:23843977 RGD:7247697 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Ins1 insulin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:6225876 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 ISO CTD Direct Evidence: therapeutic CTD PMID:20828608 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Klk1 kallikrein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:16129698 NCBI chr 1:103,779,152...103,783,270
Ensembl chr 1:94,642,687...94,646,754 		JBrowse link
G Lepr leptin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:35235096 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 IEP associated with type 2 diabetes mellitus;protein:decreased expression:myocardium of ventricle (rat) RGD PMID:22146585 RGD:155883162 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:25907942 RGD:13800893 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:25907942 RGD:13800893 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mir140 microRNA 140 ameliorates ISO RGD PMID:36044268 PMID:31078585 RGD:156430337, RGD:329347833 NCBI chr19:52,375,293...52,375,391
Ensembl chr19:35,465,577...35,465,675 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ameliorates ISO RGD PMID:36044268 RGD:156430337 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Mylk2 myosin light chain kinase 2 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:9005973 RGD:1580244 NCBI chr 3:161,836,705...161,848,609
Ensembl chr 3:141,376,691...141,387,728 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 treatment
ameliorates		 IEP
ISO		 associated with Diabetes Mellitus, Experimental RGD PMID:23453443 PMID:23353773 PMID:36044268 RGD:10412713, RGD:10412721, RGD:156430337 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:29274332 RGD:13504685 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Notch1 notch receptor 1 treatment IEP RGD PMID:32828943 RGD:405650202 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nppa natriuretic peptide A treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:23497378 RGD:7297056 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nrg1 neuregulin 1 treatment IEP associated with Diabetes Mellitus, Experimental;protein:decreased expresssion:left ventricle myocardium RGD PMID:22285193 PMID:32828943 RGD:10449013, RGD:405650202 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ameliorates ISO RGD PMID:36044268 RGD:156430337 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pln phospholamban IEP associated with Diabetes Mellitus, Experimental;protein:increased expression:heart left ventricle RGD PMID:22185592 RGD:7327207 NCBI chr20:33,166,512...33,182,241 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha IDA Strain: ZDF RGD PMID:19317897 RGD:5509944 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ryr2 ryanodine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16685413 NCBI chr17:63,081,527...63,667,141
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 ISO CTD Direct Evidence: therapeutic CTD PMID:18945756 NCBI chr16:52,805,521...52,809,316
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 treatment IEP RGD PMID:27058979 RGD:13628396 NCBI chr 6:18,975,498...19,299,704
Ensembl chr 6:13,194,662...13,535,628 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16980342 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tert telomerase reverse transcriptase treatment IEP associated with Diabetes Mellitus, Type 2 RGD PMID:21264070 RGD:11038677 NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:17909696 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Xdh xanthine dehydrogenase treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:23843977 RGD:7247697 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19141
    disease of anatomical entity 18453
      cardiovascular system disease 5545
        heart disease 3477
          cardiomyopathy 1430
            Diabetic Cardiomyopathies 60
Path 2
Term Annotations click to browse term
  disease 19141
    Developmental Disease 14667
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 13715
        genetic disease 13381
          inherited metabolic disorder 6620
            carbohydrate metabolic disorder 3414
              glucose metabolism disease 2158
                diabetes mellitus 1665
                  Diabetes Complications 541
                    Diabetic Cardiomyopathies 60
paths to the root