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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Experimental Autoimmune Neuritis
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Accession:DOID:9006647 term browser browse the term
Definition:An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
Synonyms:exact_synonym: EAN (Experimental Allergic Neuritis);   EAN (Experimental Autoimmune Neuritis);   Experimental Allergic Neuritis;   experimental autoimmune neuropathies;   experimental autoimmune neuropathy
 primary_id: MESH:D009444



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Experimental Autoimmune Neuritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam8 ADAM metallopeptidase domain 8 ISO RGD PMID:9670863 RGD:2325244 NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801
JBrowse link
G Aif1 allograft inflammatory factor 1 IEP protein:increased expression:spinal cord (rat) RGD PMID:15710454 RGD:2313042 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Anxa1 annexin A1 IEP protein:increased expression:sciatic nerve RGD PMID:10603033 RGD:2306914 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G App amyloid beta precursor protein treatment IDA RGD PMID:28446186 RGD:13782060 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Cav1 caveolin 1 IEP protein:increased phosphorylation:sciatic nerve RGD PMID:17234162 RGD:2289125 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 ISO protein:increased expression:sciatic nerve, macrophage, T cell RGD PMID:20500551 RGD:5688140 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Cd14 CD14 molecule severity IEP RGD PMID:19162137 RGD:2312712 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd28 Cd28 molecule IMP RGD PMID:12864982 RGD:2307204 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cd40 CD40 molecule IEP RGD PMID:17188497 RGD:5491181 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd40lg CD40 ligand IEP RGD PMID:17188497 RGD:5491181 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cd59b CD59b molecule IEP protein:increased expression:Schwann cell (rat) RGD PMID:10450801 RGD:1600494 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 IEP RGD PMID:18448252 RGD:4891968 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IEP RGD PMID:18448252 RGD:4891968 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014
JBrowse link
G Dcc DCC netrin 1 receptor IEP RGD PMID:16337279 RGD:2314374 NCBI chr18:64,868,987...65,972,783
Ensembl chr18:64,873,898...65,972,740
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) treatment IMP RGD PMID:11522581 RGD:11040446 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
JBrowse link
G Epas1 endothelial PAS domain protein 1 IEP RGD PMID:23603807 RGD:10395381 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Epo erythropoietin IEP RGD PMID:20361946 RGD:10400894 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Foxp3 forkhead box P3 IEP protein:decreased expression:sciatic nerve RGD PMID:30464413 RGD:38549576 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 disease_progression IEP mRNA,protein:increased expression:sciatic nerve: RGD PMID:21784136 RGD:9686114 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP RGD PMID:23603807 RGD:10395381 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase disease_progression IMP RGD PMID:17286627 RGD:5508466 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Ifnb1 interferon beta 1 ameliorates IDA RGD PMID:10494101 RGD:401854240 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Il17a interleukin 17A ISO
IEP
mRNA, protein:increased expression:sciatic nerve, inguinal lymph node RGD PMID:10785455 PMID:19207263 RGD:4888513, RGD:4831923 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1b interleukin 1 beta treatment IEP RGD PMID:18400050 RGD:7401218 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il5 interleukin 5 treatment IDA RGD PMID:22310911 RGD:11522768 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Mmp7 matrix metallopeptidase 7 IEP RGD PMID:9546322 RGD:9685357 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Mmp9 matrix metallopeptidase 9 IEP RGD PMID:9546322 RGD:9685357 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nos2 nitric oxide synthase 2 IEP protein:increased expression:nerve root, leukocyte, Schwann cell (rat) RGD PMID:15144861 RGD:1580265 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 IEP protein:increased expression: RGD PMID:12916703 RGD:5688236 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IEP protein:increased expression: RGD PMID:12916703 RGD:5688236 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rhoa ras homolog family member A IEP protein:increased expression:spinal ganglion, macrophage, T cell RGD PMID:17367505 RGD:1642966 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Spp1 secreted phosphoprotein 1 IDA RGD PMID:15531104 RGD:1581323 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tlr2 toll-like receptor 2 severity IEP RGD PMID:19162137 RGD:2312712 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 IEP mRNA:increased expression:multiple tissues RGD PMID:18434754 RGD:2312677 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr9 toll-like receptor 9 IEP mRNA:increased expression:multiple tissues RGD PMID:18434754 RGD:2312677 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
JBrowse link
G Tnf tumor necrosis factor treatment IEP RGD PMID:18400050 RGD:7401218 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 ameliorates IDA
IEP
mRNA:increased expression:sciatic nerve,peripheral blood mononuclar cell RGD PMID:28260057 PMID:28260057 RGD:127284841, RGD:127284841 NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19072
    Animal Diseases 1730
      Animal Disease Models 1676
        Experimental Nervous System Autoimmune Disease 277
          Experimental Autoimmune Neuritis 53
Path 2
Term Annotations click to browse term
  disease 19072
    disease of anatomical entity 18365
      Immune & Inflammatory Diseases 5734
        immune system disease 4924
          primary immunodeficiency disease 4302
            autoimmune disease 2361
              autoimmune disease of the nervous system 703
                Experimental Nervous System Autoimmune Disease 277
                  Experimental Autoimmune Neuritis 53
paths to the root