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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:hepatosplenic schistosomiasis
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Accession:DOID:9006550 term browser browse the term
Definition:Hepatosplenic schistosomiasis refers to the major complication of chronic infection with Schistosoma mansoni, S japonicum and S mekongi, schistosomal portal hypertension. It is usually associated with enlargement of the liver and spleen, and reversible hepatosplenomegaly may occur in early infections. It is a chronic complication, which develops as a consequence of inflammatory response.
Synonyms:exact_synonym: HSS
 narrow_synonym: hepatic schistosomiasis


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hepatosplenic schistosomiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd209a CD209a molecule ISO mRNA,protein:decreased expression:spleen,liver (mouse) RGD PMID:29386115 PMID:24729611 RGD:39938990, RGD:39938995 NCBI chr12:1,822,663...1,828,246
Ensembl chr12:1,822,663...1,828,246 		JBrowse link
G Clec4m C-type lectin domain family 4 member M ISO RGD PMID:18981244 RGD:39938988 NCBI chr12:1,915,902...1,924,529
Ensembl chr12:1,915,919...1,924,539 		JBrowse link
G Krt18 keratin 18 disease_progression ISO protein:increased expression:serum (mouse, human) RGD PMID:21357724 RGD:21406434 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
Ensembl chr10:133,157,475...133,161,166 		JBrowse link
G Mir146a microRNA 146a ISO miRNA:increased expression:liver, hepatic stellate cell (mouse)
miRNA:increased expression:liver, macrophage (mouse)
miRNA:increased expression:liver (mouse)		 RGD PMID:25116007 PMID:27780686 PMID:25051829 RGD:126925174, RGD:126925179, RGD:126925180 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Serpinf1 serpin family F member 1 ISO RGD PMID:9038736 RGD:30296660 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19104
    disease by infectious agent 2253
      parasitic infectious disease 328
        Parasitic Liver Diseases 24
          hepatosplenic schistosomiasis 5
Path 2
Term Annotations click to browse term
  disease 19104
    disease by infectious agent 2253
      parasitic infectious disease 328
        parasitic helminthiasis infectious disease 83
          Trematode Infections 41
            fasciolopsiasis 41
              schistosomiasis 34
                hepatosplenic schistosomiasis 5
paths to the root