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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Eye Injuries
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Accession:DOID:9006447 term browser browse the term
Definition:Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.
Synonyms:exact_synonym: Eye Injury
 primary_id: MESH:D005131;   RDO:0005555
 xref: EFO:0009485

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Eye Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF2 fibroblast growth factor 2 ISO protein:increased expression:lens RGD PMID:15273655 RGD:8655664 NCBI chr 7:70,089,394...70,157,423 JBrowse link
G PPARG peroxisome proliferator activated receptor gamma treatment ISO RGD PMID:18658087 RGD:8552893 NCBI chr22:48,262,743...48,407,415
Ensembl chr22:48,275,600...48,407,418 		JBrowse link
Corneal Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28038895 NCBI chr16:18,302,145...18,312,768
Ensembl chr16:18,302,142...18,312,756 		JBrowse link
G TP63 tumor protein p63 ISO RGD PMID:12167247 RGD:11568649 NCBI chr15:83,861,489...84,126,675 JBrowse link
Corneal Perforation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma ISO mRNA,protein:increased expression:corneal RGD PMID:15832292 RGD:8157597 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473 		JBrowse link
Eye Burns term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 treatment ISO RGD PMID:22553604 RGD:7364851 NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836 		JBrowse link
G IL1B interleukin 1 beta ISO protein:increased expression:retina RGD PMID:9618720 RGD:7794723 NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO protein:increased expression:cornea, neutrophil, macrophage (rat) RGD PMID:24194635 RGD:8552904 NCBI chr22:48,262,743...48,407,415
Ensembl chr22:48,275,600...48,407,418 		JBrowse link
Penetrating Eye Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF2 fibroblast growth factor 2 ISO mRNA:increased expression:retina RGD PMID:9268592 RGD:8655567 NCBI chr 7:70,089,394...70,157,423 JBrowse link
G NEO1 neogenin 1 ISO protein:increased expression:retina RGD PMID:21887516 RGD:9850142 NCBI chr26:10,173,707...10,427,732
Ensembl chr26:10,176,215...10,427,675 		JBrowse link
G RGMA repulsive guidance molecule BMP co-receptor a ISO protein:increased expression:retina RGD PMID:21887516 RGD:9850142 NCBI chr29:11,592,929...11,638,955
Ensembl chr29:11,592,604...11,638,860 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15416
    sensory system disease 6936
      eye disease 3568
        Eye Injuries 9
          Anterior Capsular Rupture, Ocular 0
          Corneal Injuries + 3
          Eye Burns 3
          Eye Foreign Bodies 0
          Penetrating Eye Injuries 3
          Posterior Capsular Rupture, Ocular 0
Path 2
Term Annotations click to browse term
  disease 15416
    disease of anatomical entity 15079
      nervous system disease 13229
        Neurologic Manifestations 9818
          sensory system disease 6936
            eye disease 3568
              Eye Injuries 9
                Anterior Capsular Rupture, Ocular 0
                Corneal Injuries + 3
                Eye Burns 3
                Eye Foreign Bodies 0
                Penetrating Eye Injuries 3
                Posterior Capsular Rupture, Ocular 0
paths to the root