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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Kidney Reperfusion Injury
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Accession:DOID:9006223 term browser browse the term
Definition:Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the kidney, including swelling; hemorrhage; necrosis; and damage from free radicals.
Synonyms:exact_synonym: Kidney Ischemia-Reperfusion Injury;   Renal Ischemia-Reperfusion Injury;   Renal Reperfusion Injury


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Kidney Reperfusion Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IMP RGD PMID:21680852 RGD:6893484 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Ace2 angiotensin converting enzyme 2 IEP mRNA:decreased expression:kidney RGD PMID:20528771 RGD:9685432 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596 		JBrowse link
G Acta1 actin, alpha 1, skeletal muscle ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr19:68,781,168...68,784,194
Ensembl chr19:68,781,168...68,786,178 		JBrowse link
G Acvr2b activin A receptor type 2B treatment ISO human construct in rat model RGD PMID:27732750 RGD:329322881 NCBI chr 8:128,016,589...128,056,193
Ensembl chr 8:128,016,526...128,048,171 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 treatment IEP RGD PMID:22015440 RGD:13703100 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344 		JBrowse link
G Adam2 ADAM metallopeptidase domain 2 IEP RGD PMID:11967014 RGD:10047130 NCBI chr15:44,418,191...44,459,570
Ensembl chr15:44,418,199...44,459,516 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 IEP RGD PMID:18272597 RGD:9684850 NCBI chr11:38,418,565...38,427,384
Ensembl chr11:38,418,101...38,427,390 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing treatment ISO RGD PMID:21412771 RGD:8695946 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Adm adrenomedullin treatment IEP
ISO 		protein:increased expression:serum: RGD PMID:20538296 PMID:20538296 RGD:7364948, RGD:7364948 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371 		JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 ISO RGD PMID:31089212 RGD:27226686 NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:135,329,606...135,367,035 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member ISO RGD PMID:22022451 RGD:7241603 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219 		JBrowse link
G Anxa1 annexin A1 treatment IDA RGD PMID:20953576 RGD:7421585 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831 		JBrowse link
G Anxa5 annexin A5 ISO RGD PMID:21918686 RGD:7242028 NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 treatment IEP RGD PMID:26362957 RGD:13703110 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772 		JBrowse link
G Apoa1 apolipoprotein A1 treatment ISO RGD PMID:18535924 RGD:7241574 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729 		JBrowse link
G Atm ATM serine/threonine kinase IEP protein:increased expression:kidney RGD PMID:22768306 RGD:10053607 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:23151253 RGD:10054101 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP RGD PMID:18221257 PMID:29285062 RGD:2293026, RGD:13792599 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bdkrb1 bradykinin receptor B1 ISO RGD PMID:18725957 RGD:7241559 NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:130,275,478...130,280,973 		JBrowse link
G Becn1 beclin 1 treatment IEP RGD PMID:26412257 RGD:11561958 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002 		JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger ISO mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr17:86,240,683...86,250,044
Ensembl chr17:86,243,491...86,250,024 		JBrowse link
G Bnip3 BCL2 interacting protein 3 IEP mRNA, protein:increased expression:kidney RGD PMID:23698117 RGD:11561968 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962 		JBrowse link
G C3 complement C3 treatment IEP RGD PMID:19691975 RGD:7411689 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339 		JBrowse link
G Calca calcitonin-related polypeptide alpha IMP RGD PMID:19194162 RGD:7204479 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529 		JBrowse link
G Casp3 caspase 3 treatment IEP RGD PMID:23151253 RGD:10054101 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 IEP RGD PMID:17596683 RGD:5684536 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 treatment ISO RGD PMID:22160777 RGD:7247742 NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,525,862...67,530,575 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment
ameliorates 		ISO
IDA 		mRNA, protein:increased expression:kidney, lung, serum RGD PMID:24920753 PMID:20396927 PMID:18650485 RGD:329845564, RGD:4891433, RGD:11526113 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccn1 cellular communication network factor 1 ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883 		JBrowse link
G Cd14 CD14 molecule ISO mRNA,protein:increased expression:kidney RGD PMID:10966493 RGD:7204444 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292 		JBrowse link
G Cd40 CD40 molecule treatment IMP RGD PMID:25993320 RGD:11251055 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cfb complement factor B ISO RGD PMID:16467447 PMID:12538716 RGD:7242709, RGD:7242734 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740 		JBrowse link
G Cfh complement factor H treatment IEP
ISO 		protein:decreased expression:serum: RGD PMID:20538296 PMID:20538296 RGD:7364948, RGD:7364948 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:54,062,531...54,164,532 		JBrowse link
G Ciita class II, major histocompatibility complex, transactivator ISO RGD PMID:14569092 RGD:7242896 NCBI chr10:5,646,854...5,694,393
Ensembl chr10:5,647,085...5,694,342 		JBrowse link
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 ISO mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr  X:71,390,328...71,395,023
Ensembl chr  X:71,390,331...71,393,649 		JBrowse link
G Col1a1 collagen type I alpha 1 chain ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col3a1 collagen type III alpha 1 chain ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232 		JBrowse link
G Csf1 colony stimulating factor 1 ISO mRNA:increased expression:kidney RGD PMID:23143303 PMID:19196448 RGD:7257565, RGD:7257570 NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468 		JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO RGD PMID:23143303 RGD:7257565 NCBI chr18:56,834,152...56,860,804
Ensembl chr18:56,817,049...56,860,806 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 ISO RGD PMID:22189844 PMID:9407517 RGD:7204675, RGD:7204727 NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:69,813,265...69,819,973 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 ISO RGD PMID:20038794 RGD:7257679 NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:83,183,808...83,188,602 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 IEP protein:increased expression:kidney RGD PMID:29073721 RGD:13825150 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 treatment IMP RGD PMID:23552495 RGD:7244372 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
G Daxx death-domain associated protein ISO protein:increased expression:kidney: RGD PMID:18480747 PMID:18480747 RGD:9587836, RGD:9587836 NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,971,941...4,977,720 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 ISO protein:increased expression:kidney (mouse) RGD PMID:31383731 RGD:151347540 NCBI chr20:3,047,269...3,069,277
Ensembl chr20:3,050,375...3,069,276 		JBrowse link
G Dhfr dihydrofolate reductase treatment IEP mRNA,protein:decreased expression:kidney: RGD PMID:18408363 RGD:11040540 NCBI chr 2:25,320,895...25,346,004 JBrowse link
G Drd3 dopamine receptor D3 treatment IDA RGD PMID:25989500 RGD:13506961 NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760 		JBrowse link
G Eed embryonic ectoderm development ISO mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr 1:153,280,419...153,307,537
Ensembl chr 1:153,280,422...153,307,500 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 IEP mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chr19:69,765,276...69,804,681 JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 IEP mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:77,385,549...77,411,015 		JBrowse link
G Elane elastase, neutrophil expressed treatment IMP RGD PMID:16980042 RGD:10450580 NCBI chr 7:10,467,877...10,469,725
Ensembl chr 7:10,467,877...10,469,725 		JBrowse link
G Eng endoglin IEP
ISO 		mRNA, protein:increased expression:kidney (rat) RGD PMID:16751653 PMID:16751653 RGD:7248779, RGD:7248779 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:36,326,202...36,370,933 		JBrowse link
G Ep300 E1A binding protein p300 IEP protein:altered localization:kidney (rat) RGD PMID:23936185 RGD:7257563 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:19961832 PMID:25581532 RGD:10401077, RGD:11041698 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:77,624,223...77,687,183 		JBrowse link
G F3 coagulation factor III, tissue factor IEP protein:decreased expression:lung RGD PMID:25883098 RGD:11341735 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369 		JBrowse link
G Fas Fas cell surface death receptor treatment IEP RGD PMID:29285062 RGD:13792599 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Faslg Fas ligand treatment IEP RGD PMID:29285062 RGD:13792599 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Fcgr1a Fc gamma receptor 1A treatment ISO RGD PMID:22402584 RGD:9685699 NCBI chr 2:186,539,941...186,548,941
Ensembl chr 2:186,539,942...186,548,858 		JBrowse link
G Fga fibrinogen alpha chain IEP mRNA,protein:increased expression:kidney RGD PMID:21685370 RGD:7175292 NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577 		JBrowse link
G Fgb fibrinogen beta chain treatment IEP
ISO 		mRNA, protein:increased expression:kidney RGD PMID:21685370 PMID:21685370 RGD:7175292, RGD:7175292 NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:170,692,965...170,705,434 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 exacerbates
ameliorates 		ISO
IMP 		protein:increased phosphorylation:kidney (mouse) RGD PMID:20591940 PMID:32523960 PMID:29344510 PMID:22688984 RGD:155663667, RGD:155782882, RGD:155782904, RGD:155882537 NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:194,175,705...194,280,914 		JBrowse link
G Fgg fibrinogen gamma chain IEP mRNA,protein:increased expression:kidney RGD PMID:21685370 RGD:7175292 NCBI chr 2:170,652,929...170,660,372
Ensembl chr 2:170,652,234...170,661,170 		JBrowse link
G Fn1 fibronectin 1 IEP RGD PMID:11352844 RGD:7205629 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO RGD PMID:19095962 RGD:7242184 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase IEP RGD PMID:17250641 RGD:2307361 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration treatment IEP
ISO 		protein:increased expression:kidney: RGD PMID:20332418 PMID:20332418 RGD:9685723, RGD:9685723 NCBI chr10:14,223,023...14,225,736
Ensembl chr10:14,223,023...14,225,935 		JBrowse link
G Glo1 glyoxalase 1 IMP RGD PMID:19211689 RGD:7242566 NCBI chr20:8,665,061...8,683,095
Ensembl chr20:8,665,061...8,683,191 		JBrowse link
G Gpx3 glutathione peroxidase 3 IEP protein:decreased expression:kidney
mRNA:decreased expression:kidney 		RGD PMID:37033969 PMID:22442209 RGD:401827821, RGD:401827906 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405 		JBrowse link
G Gsr glutathione-disulfide reductase treatment IEP RGD PMID:24630969 RGD:10401866 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 IEP mRNA, protein:decreased expression:kidney RGD PMID:29137244 RGD:158014894 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 IEP protein:decreased expression:kidney RGD PMID:37033969 RGD:401827821 NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,083...12,873,019 		JBrowse link
G H2ax H2A.X variant histone treatment IEP RGD PMID:23726287 RGD:8693706 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Has1 hyaluronan synthase 1 IEP RGD PMID:22529164 RGD:9588636 NCBI chr 1:67,366,460...67,378,686
Ensembl chr 1:67,366,460...67,378,444 		JBrowse link
G Has2 hyaluronan synthase 2 IEP RGD PMID:22529164 RGD:9588636 NCBI chr 7:90,002,929...90,028,933
Ensembl chr 7:90,002,929...90,018,535 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 IEP
ISO 		protein:increased expression:urine: RGD PMID:23552495 PMID:23085062 PMID:23019274 RGD:7244372, RGD:7245489, RGD:7245495 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha treatment
severity 		IDA
IMP 		RGD PMID:17519789 PMID:22432008 RGD:1626334, RGD:9068883 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hmox1 heme oxygenase 1 treatment IMP RGD PMID:21291499 RGD:10755580 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hsf1 heat shock transcription factor 1 IEP protein:increased expression:kidney (rat) RGD PMID:23102208 RGD:10402775 NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 IEP RGD PMID:7569112 RGD:7242788 NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372 		JBrowse link
G Hyal1 hyaluronidase 1 IEP RGD PMID:22529164 RGD:9588636 NCBI chr 8:117,129,311...117,133,162
Ensembl chr 8:117,129,277...117,133,146 		JBrowse link
G Hyal2 hyaluronidase 2 IEP RGD PMID:22529164 RGD:9588636 NCBI chr 8:117,121,802...117,125,494
Ensembl chr 8:117,121,787...117,125,493 		JBrowse link
G Ifng interferon gamma treatment ISO RGD PMID:28355607 RGD:14975115 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor IEP mRNA: increased expression: kidney: 3 and 5 days post ischemia RGD PMID:10990448 RGD:7242905 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta treatment IMP RGD PMID:19546526 RGD:7495779 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Il10 interleukin 10 treatment IDA
ISO 		RGD PMID:24079335 PMID:28664613 RGD:7364864, RGD:14975137 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il12b interleukin 12B ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194 		JBrowse link
G Il18 interleukin 18 treatment IMP RGD PMID:22089199 RGD:8655971 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta ameliorates IDA
ISO 		RGD PMID:20030532 PMID:24920753 RGD:7175501, RGD:329845564 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO rat model treated with human protein
mouse model treated with human protein 		RGD PMID:18363573 PMID:16849996 PMID:9555664 RGD:6907101, RGD:6907359, RGD:6909149 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il6 interleukin 6 ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Inhbb inhibin subunit beta B IEP protein:increased expression:serum (rat) RGD PMID:27732750 RGD:329322881 NCBI chr13:33,083,671...33,089,373
Ensembl chr13:33,083,671...33,089,609 		JBrowse link
G Itgb2 integrin subunit beta 2 ISO
IMP 		Associated with renal transplant patients RGD PMID:20504838 PMID:11007822 RGD:6907049, RGD:6907073 NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 IEP protein:decreased expression:kidney RGD PMID:21250976 RGD:7297045 NCBI chr 1:105,727,473...105,731,167
Ensembl chr 1:105,727,570...105,731,169 		JBrowse link
G Kl Klotho treatment IEP
ISO 		mRNA,protein:decreased expression:renal tubule: RGD PMID:16204278 PMID:16204278 RGD:10403064, RGD:10403064 NCBI chr12:5,326,003...5,367,016
Ensembl chr12:5,325,959...5,367,015 		JBrowse link
G Kmt2a lysine methyltransferase 2A ISO protein:increased expression:kidney (mouse) RGD PMID:31570196 RGD:155888490 NCBI chr 8:54,013,547...54,089,219
Ensembl chr 8:54,013,547...54,089,317 		JBrowse link
G Lcn2 lipocalin 2 IEP
ISO 		protein:increased expression:urine:
mRNA,protein:increased expression:kidney:
mRNA,protein:increased expression:kidney,urine 		RGD PMID:23364806 PMID:23085062 PMID:20181666 PMID:27800610 RGD:7245469, RGD:7245489, RGD:126779563, RGD:126790572 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Lep leptin resistance IDA RGD PMID:22969992 RGD:6909133 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Lgals3 galectin 3 IEP mRNA:increased expression:kidney RGD PMID:10980121 RGD:9685228 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:23,086,841...23,111,737 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha treatment ISO
IEP 		RGD PMID:20075199 PMID:26412257 RGD:11561916, RGD:11561958 NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:164,243,093...164,244,850 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 treatment IMP RGD PMID:23952292 RGD:10412647 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898 		JBrowse link
G Mc1r melanocortin 1 receptor IEP protein:decreased expression:kidney outer medulla RGD PMID:18790174 RGD:5687322 NCBI chr19:68,360,950...68,363,877
Ensembl chr19:68,360,950...68,363,877 		JBrowse link
G Mir146a microRNA 146a treatment IEP RGD PMID:27760486 RGD:155882556 NCBI chr10:28,349,996...28,350,090 JBrowse link
G Mir320a microRNA 320a treatment IEP RGD PMID:31089916 PMID:27760486 RGD:155882543, RGD:155882556 NCBI chr15:51,926,088...51,926,169
Ensembl chr15:51,926,088...51,926,169 		JBrowse link
G Mir381 microRNA 381 IEP RNA:decreased expression:kidney RGD PMID:29073721 RGD:13825150 NCBI chr 6:134,562,381...134,562,441 JBrowse link
G Mir423 microRNA 423 treatment IMP RGD PMID:29137244 RGD:158014894 NCBI chr10:62,412,272...62,412,350 JBrowse link
G Mir494 microRNA 494 ameliorates ISO RGD PMID:23160513 RGD:155883172 NCBI chr 6:134,550,115...134,550,197
Ensembl chr 6:134,550,114...134,550,198 		JBrowse link
G Mpo myeloperoxidase IEP
ISO 		protein:increased activity:kidney RGD PMID:22950848 PMID:18055546 RGD:6909167, RGD:7174699 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Muc1 mucin 1, cell surface associated treatment IDA RGD PMID:22019164 RGD:7245959 NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:176,933,047...176,938,491 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IEP mRNA:increased expression:kidney (rat) RGD PMID:17220792 RGD:7207777 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 IEP
ISO 		RGD PMID:24096033 PMID:22160772 RGD:13801197, RGD:13801199 NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:253,357,841...253,362,936 		JBrowse link
G Nes nestin IEP RGD PMID:24503548 RGD:11570523 NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 treatment IEP RGD PMID:31089916 RGD:155882543 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nos2 nitric oxide synthase 2 treatment IEP RGD PMID:18408363 RGD:11040540 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP RGD PMID:29291552 PMID:18408363 RGD:13504682, RGD:11040540 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Nox1 NADPH oxidase 1 treatment IEP RGD PMID:34244746 RGD:329955363 NCBI chr  X:101,572,338...101,625,571
Ensembl chr  X:101,572,340...101,595,520 		JBrowse link
G Nppa natriuretic peptide A ISO RGD PMID:20471588 RGD:7247717 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP RGD PMID:21545725 RGD:11035217 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 severity ISO mRNA:increased expression:kidney RGD PMID:22343121 PMID:22343121 RGD:14700869, RGD:14700869 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase IEP RGD PMID:12531391 RGD:2317150 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604 		JBrowse link
G Pax2 paired box 2 IEP mRNA, protein:increased expression:kidney RGD PMID:12444203 RGD:727468 NCBI chr 1:253,555,447...253,646,623
Ensembl chr 1:253,555,418...253,645,438 		JBrowse link
G Pdgfb platelet derived growth factor subunit B IEP mRNA,protein:increased expression:tubule, S3 segment: RGD PMID:10550325 RGD:8554477 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha IEP mRNA:increased expression:kidney RGD PMID:10550325 RGD:8554477 NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,360,028...33,408,516 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IMP
IEP 		mRNA:increased expression:kidney RGD PMID:12819032 PMID:10550325 RGD:1580850, RGD:8554477 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233 		JBrowse link
G Peg10 paternally expressed 10 ISO mRNA:increased expression:kidney (mouse) RGD PMID:16778176 RGD:401851077 NCBI chr 4:33,809,026...33,822,224
Ensembl chr 4:33,817,190...33,819,166
Ensembl chr 4:33,817,190...33,819,166 		JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel IEP protein:increased expression:kidney (rat) RGD PMID:12454224 RGD:1580868 NCBI chr14:5,541,821...5,585,140 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha treatment IDA RGD PMID:24918615 RGD:10059636 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Ptgis prostaglandin I2 synthase ISO mRNA:increased expression:kidney (mouse) RGD PMID:30413885 RGD:401959745 NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650 		JBrowse link
G Rnls renalase, FAD-dependent amine oxidase ISO mRNA,protein:decreased expression:kidney,plasma: RGD PMID:23393318 PMID:23393318 RGD:7327166, RGD:7327166 NCBI chr 1:240,450,702...240,723,472
Ensembl chr 1:240,450,702...240,723,043 		JBrowse link
G Sell selectin L IEP RGD PMID:7537789 RGD:597015754 NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600 		JBrowse link
G Serpina1 serpin family A member 1 treatment ISO RGD PMID:28235038 RGD:14695051 NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:128,619,382...128,660,703 		JBrowse link
G Serpinc1 serpin family C member 1 severity IMP RGD PMID:26108065 PMID:26108065 RGD:11354006, RGD:11354006 NCBI chr13:75,790,558...75,804,826
Ensembl chr13:75,790,546...75,817,643 		JBrowse link
G Serpinc1em2Mcwi serpin family C member 1; ZFN induced mutant 2, Medical College of Wisconsin IMP RGD PMID:26108065 RGD:11354006
G Serpine1 serpin family E member 1 ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Shh sonic hedgehog signaling molecule ISO mRNA, protein:increased expression:kidney RGD PMID:24744439 RGD:12859042 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901 		JBrowse link
G Sirt1 sirtuin 1 treatment IEP RGD PMID:22324445 RGD:9495930 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Six2 SIX homeobox 2 ISO mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr 6:14,727,756...14,734,219
Ensembl chr 6:14,727,859...14,731,941 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 IEP RGD PMID:21835768 RGD:7243877 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 IEP RGD PMID:21835768 RGD:7243877 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Slc34a1 solute carrier family 34 member 1 IEP protein:decreased expression:renal proximal tubule, brush border membrane (rat) RGD PMID:15775707 RGD:2311304 NCBI chr17:9,224,010...9,238,983
Ensembl chr17:9,224,010...9,238,983 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IEP RGD PMID:12819032 RGD:1580850 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 severity ISO RGD PMID:12709397 RGD:7244143 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795 		JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit ISO mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr10:65,464,948...65,510,846
Ensembl chr10:65,464,969...65,510,846 		JBrowse link
G Tfpi tissue factor pathway inhibitor ISO RGD PMID:11796005 RGD:11062062 NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:89,939,868...89,980,742 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tlr2 toll-like receptor 2 treatment
severity 		IDA
ISO 		RGD PMID:23239000 PMID:23023072 PMID:22750071 PMID:20130923 PMID:11801667 RGD:7207892, RGD:7207894, RGD:7207896, RGD:7240552, RGD:7241087 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tlr4 toll-like receptor 4 treatment IDA
ISO 		RGD PMID:23239000 PMID:20130923 PMID:11801667 RGD:7207892, RGD:7240552, RGD:7241087 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor ameliorates IEP
ISO 		protein:increased expression:serum RGD PMID:19925291 PMID:24920753 RGD:2315112, RGD:329845564 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO mRNA:increased expression:lung RGD PMID:22728466 RGD:7245543 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 IEP protein:increased expression:kidney RGD PMID:20164827 RGD:7240507 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vwf von Willebrand factor IEP protein:increased expression:serum: RGD PMID:12684225 RGD:11080744 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757 		JBrowse link
G Wt1 WT1 transcription factor ISO mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:112,021,641...112,068,444 		JBrowse link
G Xdh xanthine dehydrogenase treatment IMP associated with Diabetes Mellitus, Type 2 RGD PMID:22995295 PMID:20616412 RGD:7247637, RGD:7247695 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350 		JBrowse link
G Zfp667 zinc finger protein 667 ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr 1:76,634,897...76,655,133
Ensembl chr 1:76,634,901...76,655,213 		JBrowse link
Chronic Allograft Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 IEP RGD PMID:20176611 RGD:11541086 NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:60,055,866...60,112,600 		JBrowse link
G Alb albumin disease_progression ISO RGD PMID:24370342 RGD:11035281 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 ISO RGD PMID:17298994 RGD:7241819 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccn2 cellular communication network factor 2 disease_progression IEP mRNA, protein:increased expression:kidney (rat) RGD PMID:19921985 RGD:150517553 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Clu clusterin treatment IEP RGD PMID:22494435 RGD:9068431 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Cs citrate synthase treatment IDA RGD PMID:20005400 RGD:243048470 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938 		JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO RGD PMID:22845765 RGD:7241226 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826 		JBrowse link
G Mmp7 matrix metallopeptidase 7 treatment IDA RGD PMID:18209025 RGD:9685339 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755 		JBrowse link
G Pdgfa platelet derived growth factor subunit A IEP RGD PMID:11889420 RGD:11080974 NCBI chr12:20,759,366...20,780,337
Ensembl chr12:20,754,208...20,780,322 		JBrowse link
G Pdgfb platelet derived growth factor subunit B IEP mRNA:increased expression:kidney: RGD PMID:15785371 PMID:11889420 RGD:10449491, RGD:11080974 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha IEP RGD PMID:11889420 RGD:11080974 NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,360,028...33,408,516 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IEP RGD PMID:11889420 RGD:11080974 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233 		JBrowse link
G Plau plasminogen activator, urokinase ISO protein:increased secretion:T lymphocyte (human) RGD PMID:16387096 RGD:7241259 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO protein:increased expression:kidney: RGD PMID:16221712 RGD:13208600 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Serpine1 serpin family E member 1 treatment ISO protein:increased expression:kidney: RGD PMID:16221712 PMID:18192922 RGD:13208600, RGD:13208601 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 0
      cardiovascular system disease 5558
        vascular disease 4039
          Reperfusion Injury 822
            Kidney Reperfusion Injury 168
              Chronic Allograft Nephropathy 15
Path 2
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      Urogenital Diseases 5238
        urinary system disease 2590
          kidney disease 2335
            kidney failure 576
              acute kidney failure 330
                Kidney Reperfusion Injury 168
                  Chronic Allograft Nephropathy 15
paths to the root