RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Pruritus
Accession: DOID:9006202
browse the term
Definition: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
Synonyms: exact_synonym: Itching; Pruritis
primary_id: MESH:D011537
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Abcb11
ATP binding cassette subfamily B member 11
ISO
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Pruritus
CTD ClinVar
PMID:15300568 PMID:17855769 PMID:18049162 PMID:25741868 PMID:28492532 PMID:31015375 More...
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Ahr
aryl hydrocarbon receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27869817
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Artn
artemin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27869817
NCBI chr 5:131,458,596...131,470,193
Ensembl chr 5:131,464,756...131,468,025
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F2rl1
F2R like trypsin receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19712758
NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
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Grk2
G protein-coupled receptor kinase 2
severity
ISO
RGD
PMID:29530536
RGD:13513974
NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582
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Grp
gastrin releasing peptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29669290
NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061
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Hrh1
histamine receptor H 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19652466
NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
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Hrh4
histamine receptor H4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19652466
NCBI chr18:4,166,270...4,182,426
Ensembl chr18:4,166,270...4,246,345
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Nmb
neuromedin B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29669290
NCBI chr 1:134,869,446...134,875,507
Ensembl chr 1:134,869,446...134,872,190
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Oprm1
opioid receptor, mu 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27192616
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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Pdyn
prodynorphin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29669290
NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
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Scn9a
sodium voltage-gated channel alpha subunit 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24820863
NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516
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Tac1
tachykinin, precursor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19652466
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tpsab1
tryptase alpha/beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27749843
NCBI chr10:14,360,396...14,362,811
Ensembl chr10:14,360,396...14,362,811
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Ccdc47
coiled-coil domain containing 47
ISO
ClinVar Annotator: match by term: Trichohepatoneurodevelopmental syndrome
OMIM ClinVar
PMID:25741868 PMID:30401460
NCBI chr10:91,130,303...91,148,829
Ensembl chr10:91,130,303...91,148,881
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all