RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Peritoneal Diseases
Accession: DOID:9006175
browse the term
Definition: Pathological processes involving the PERITONEUM.
Synonyms: exact_synonym: Peritoneal Disease; disease of peritoneum
primary_id: MESH:D010532
xref: EFO:0009541
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Mir17
microRNA 17
ISO
associated with end stage renal failure
RGD
PMID:30598338
RGD:25823143
NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712
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Notch1
notch receptor 1
IMP
mRNA:increased expression: :
RGD
PMID:20056840
RGD:2325288
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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F2
coagulation factor II, thrombin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24282370
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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F5
coagulation factor V
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24282370
NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317
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Gp1bb
glycoprotein Ib platelet subunit beta
ISO
RGD
PMID:17095718
RGD:11040529
NCBI chr11:82,378,216...82,379,393
Ensembl chr11:82,378,199...82,379,392
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Pf4
platelet factor 4
ameliorates
ISO
RGD
PMID:23568488
RGD:329901761
NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
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Icam1
intercellular adhesion molecule 1
treatment
IMP
RGD
PMID:7858885
RGD:11522711
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Jak2
Janus kinase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20434300
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Serpind1
serpin family D member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1831893
NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519
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Trem1
triggering receptor expressed on myeloid cells 1
ameliorates
IDA
RGD
PMID:18091551
RGD:127284848
NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
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Mlh1
mutL homolog 1
ISO
ClinVar Annotator: match by term: Primary peritoneal carcinoma
ClinVar
PMID:25741868
NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
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Ace
angiotensin I converting enzyme
treatment
IMP ISO
RGD
PMID:15770604 PMID:19270231
RGD:12879430 , RGD:12879821
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Ager
advanced glycosylation end product-specific receptor
treatment
IDA
associated with Diabetic Nephropathies
RGD
PMID:19759273
RGD:7244162
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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Ccl2
C-C motif chemokine ligand 2
treatment
ISO
RGD
PMID:23032084
RGD:14995948
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Dnmt1
DNA methyltransferase 1
IEP
protein:increased expression:peritoneum:
RGD
PMID:25256793
RGD:9588609
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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Ern1
endoplasmic reticulum to nucleus signaling 1
treatment
IMP
RGD
PMID:31836774
RGD:32733624
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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F10
coagulation factor X
IEP
RGD
PMID:19458308
RGD:7394780
NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
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F3
coagulation factor III, tissue factor
IEP
RGD
PMID:19458308
RGD:7394780
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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F5
coagulation factor V
IEP
RGD
PMID:19458308
RGD:7394780
NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317
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Fgf10
fibroblast growth factor 10
treatment
ISO
miR-145 inhibitor mRNA:decreased expression:peritoneum (mouse)
RGD
PMID:31431501 PMID:31431501
RGD:126928131 , RGD:126928131
NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866
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Mir21
microRNA 21
IEP
RNA:increased expression:peritoneal fluid,tissue
RGD
PMID:30515805
RGD:40925948
NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
RGD
PMID:22101032
RGD:6771356
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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Serpinc1
serpin family C member 1
treatment
ISO
associated with Peritonitis
RGD
PMID:18458955
RGD:11035266
NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
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Serpine1
serpin family E member 1
ISO
protein:increased expression:peritoneal fluid:
RGD
PMID:25530106
RGD:13208550
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Serpinh1
serpin family H member 1
disease_progression treatment
IEP ISO IMP
protein:increased expression:peritoneum (rat)
RGD
PMID:12691502 PMID:32585450 PMID:15458466 PMID:12911538
RGD:41410779 , RGD:41410783 , RGD:41410782 , RGD:41410781
NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801
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Spry1
sprouty RTK signaling antagonist 1
IEP
mRNA, protein:decreased expression:peritoneal fluid,tissue
RGD
PMID:30515805
RGD:40925948
NCBI chr 2:120,557,256...120,561,917
Ensembl chr 2:120,556,706...120,566,189
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Tgfb1
transforming growth factor, beta 1
treatment
ISO IEP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:17199790 PMID:28190234
RGD:14985233
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnfaip6
TNF alpha induced protein 6
treatment
IMP
RGD
PMID:22912904
RGD:7777188
NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
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Xbp1
X-box binding protein 1
treatment
IEP
RGD
PMID:31836774
RGD:32733624
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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Lats1
large tumor suppressor kinase 1
ISO
ClinVar Annotator: match by term: Malignant peritoneal mesothelioma
ClinVar
NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640
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Lats2
large tumor suppressor kinase 2
ISO
ClinVar Annotator: match by term: Malignant peritoneal mesothelioma
ClinVar
NCBI chr15:31,825,068...31,877,193
Ensembl chr15:31,825,092...31,877,220
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Mecom
MDS1 and EVI1 complex locus
ISO
ClinVar Annotator: match by term: Malignant peritoneal mesothelioma
ClinVar
NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590
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Traf7
TNF receptor associated factor 7
ISO
DNA:missense mutations:multiple
RGD
PMID:30171198
RGD:151356964
NCBI chr10:13,533,570...13,552,290
Ensembl chr10:13,533,570...13,552,203
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Calb2
calbindin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22784439
NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438
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Ctnnb1
catenin beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22784439
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23621518
NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865
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Mcam
melanoma cell adhesion molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22784439 PMID:23621518
NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571
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Mlana
melan-A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22784439
NCBI chr 1:227,469,537...227,483,343
Ensembl chr 1:227,469,537...227,483,343
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Muc1
mucin 1, cell surface associated
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22784439
NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
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Pdpn
podoplanin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22784439
NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
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Slc2a1
solute carrier family 2 member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22784439
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Vim
vimentin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22784439
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Wt1
WT1 transcription factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22784439
NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
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Brca1
BRCA1, DNA repair associated
ISO
ClinVar Annotator: match by term: Peritoneum cancer
ClinVar
PMID:20104584 PMID:25741868 PMID:26467025 PMID:28492532 PMID:29446198 PMID:31853058 More...
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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Cebpb
CCAAT/enhancer binding protein beta
severity
ISO
associated with stomach cancer
RGD
PMID:26514342
RGD:11556383
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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Gp1ba
glycoprotein Ib platelet subunit alpha
sexual_dimorphism
ISO
associated with stomach cancer;protein:altered expression:peritoneum (human)
RGD
PMID:32724431
RGD:42722625
NCBI chr10:55,352,938...55,355,804
Ensembl chr10:55,352,899...55,356,774
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Prg2
proteoglycan 2, pro eosinophil major basic protein
severity
ISO
associated with colorectal cancer;protein:decreased expression:colorectum, eosinophil (human)
RGD
PMID:28439450
RGD:40902993
NCBI chr 3:70,062,535...70,066,102
Ensembl chr 3:70,062,535...70,066,101
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A2m
alpha-2-macroglobulin
IEP
RGD
PMID:16538883
RGD:1598512
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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Ada
adenosine deaminase
IDA IEP
protein:increased expression:peritoneal fluid protein:decreased activity:serum
RGD
PMID:15969953 PMID:15373900
RGD:1624309 , RGD:152995406
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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Aldob
aldolase, fructose-bisphosphate B
IEP
mRNA:increased expression:liver (rat)
RGD
PMID:8403244
RGD:2313429
NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
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Alox15
arachidonate 15-lipoxygenase
ISO
RGD
PMID:18941242
RGD:5509607
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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Becn1
beclin 1
IEP
protein:increased expression:
RGD
PMID:22001349
RGD:6483066
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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C5
complement C5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19284563 PMID:19346296
NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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Cd40
CD40 molecule
ISO
RGD
PMID:15780086
RGD:7248438
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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Cd40lg
CD40 ligand
ISO
RGD
PMID:15780086
RGD:7248438
NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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Esr1
estrogen receptor 1
treatment
IDA
RGD
PMID:23063870
RGD:8553243
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
treatment
IDA
RGD
PMID:23063870
RGD:8553243
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Foxp1
forkhead box P1
ISO
human gene in a mouse model
RGD
PMID:18799727
RGD:11561898
NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258
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Gp1ba
glycoprotein Ib platelet subunit alpha
exacerbates
ISO
RGD
PMID:20716766
RGD:42722627
NCBI chr10:55,352,938...55,355,804
Ensembl chr10:55,352,899...55,356,774
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Gsk3b
glycogen synthase kinase 3 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16713974
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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Gstp1
glutathione S-transferase pi 1
ISO
RGD
PMID:18962899
RGD:4140945
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Gusb
glucuronidase, beta
IEP
protein:altered expression:peritoneal cells (rat)
RGD
PMID:185091
RGD:42722008
NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
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Ifng
interferon gamma
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:19804847 PMID:28593696
RGD:14974254
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il6
interleukin 6
ISO
RGD
PMID:26601826
RGD:14975296
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Itgam
integrin subunit alpha M
ameliorates
ISO
DNA:missense mutation:CDS:p.I332G (mouse)
RGD
PMID:32938725
RGD:329853755
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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Itgb2
integrin subunit beta 2
ameliorates
ISO
RGD
PMID:18239087
RGD:127345091
NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
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Mir155
microRNA 155
ISO
associated with Hypothermia
RGD
PMID:25231976 PMID:24708712
RGD:21079419 , RGD:21079469
NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
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Mir21
microRNA 21
ISO
RGD
PMID:26382295
RGD:11342022
NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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Nppa
natriuretic peptide A
ISO
RGD
PMID:23422200
RGD:7247713
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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Pecam1
platelet and endothelial cell adhesion molecule 1
treatment
ISO
RGD
PMID:8113674
RGD:11541096
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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Plat
plasminogen activator, tissue type
ISO
RGD
PMID:18571586
RGD:6484139
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Plau
plasminogen activator, urokinase
ISO
RGD
PMID:18571586
RGD:6484139
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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Plaur
plasminogen activator, urokinase receptor
ISO
RGD
PMID:20693875
RGD:6484122
NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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Ptgis
prostaglandin I2 synthase
ameliorates
ISO
RGD
PMID:26611322
RGD:11536046
NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
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Tmem67
transmembrane protein 67
ISO
ClinVar Annotator: match by term: Peritonitis
ClinVar
PMID:19466712 PMID:19508969 PMID:19540516 PMID:19574260 PMID:20607301 PMID:21068128 PMID:21866095 PMID:23559409 PMID:25741868 PMID:26035863 PMID:26092869 PMID:28492532 More...
NCBI chr 5:25,536,458...25,589,378
Ensembl chr 5:25,536,458...25,589,334
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Tnf
tumor necrosis factor
IEP ISO
protein:increased expression:plasma
RGD
PMID:20819637 PMID:26601826
RGD:4143378 , RGD:14975296
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Xdh
xanthine dehydrogenase
IEP
RGD
PMID:1443884 PMID:8367813
RGD:13210513 , RGD:13210579
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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Edn1
endothelin 1
IEP
mRNA, protein:increased expression:kidney, peritubular capillary, proximal tubule (rat)
RGD
PMID:11285964
RGD:8662302
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Xdh
xanthine dehydrogenase
IDA
protein:increased activity:kidney
RGD
PMID:18629585
RGD:7247655
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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Clec4m
C-type lectin domain family 4 member M
susceptibility
ISO
RGD
PMID:15583012
RGD:39939009
NCBI chr12:1,915,902...1,924,529
Ensembl chr12:1,915,919...1,924,539
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Csf3
colony stimulating factor 3
treatment
ISO
RGD
PMID:8656607
RGD:11039538
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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F2
coagulation factor II, thrombin
severity
ISO
RGD
PMID:18927430
RGD:40818433
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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F5
coagulation factor V
disease_progression
ISO
RGD
PMID:25690763
RGD:11564333
NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317
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Il27
interleukin 27
exacerbates
ISO
RGD
PMID:16880260
RGD:126790504
NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
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Il6
interleukin 6
IEP
protein:increased expression:plasma (rat)
RGD
PMID:19897171
RGD:11062137
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Kl
Klotho
disease_progression
ISO
RGD
PMID:23364432
RGD:10403048
NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
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Mir155
microRNA 155
ISO
associatd with liver cirrhosis
RGD
PMID:28074870
RGD:21079477
NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
treatment
ISO
RGD
PMID:11850627
RGD:737789
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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Pten
phosphatase and tensin homolog
ameliorates
ISO
associated with Escherichia Coli Infections
RGD
PMID:21521784
RGD:127285602
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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Serpinf1
serpin family F member 1
ISO
protein:increased expression:peritoneal fluid (human)
RGD
PMID:8869327
RGD:30296661
NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
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