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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Pulmonary Hypertension, Hypoxia-Induced
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Accession:DOID:9006166 term browser browse the term
Definition:Increased vascular resistance in the pulmonary circulation, secondary to hypoxia.
Synonyms:primary_id: RDO:9000421


show annotations for term's descendants           Sort by:
Pulmonary Hypertension, Hypoxia-Induced term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor treatment IMP RGD PMID:33836606 RGD:401940192 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP mRNA:increased expression:lung (rat) RGD PMID:33836606 RGD:401940192 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Egfr epidermal growth factor receptor treatment IMP RGD PMID:31264901 RGD:38599217 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 IEP RGD PMID:16761101 RGD:11252085 NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 IEP RGD PMID:16761101 RGD:11252085 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase treatment IMP RGD PMID:25063801 RGD:10449119 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 IEP mRNA:decreased expression:lung (rat) RGD PMID:19823174 RGD:4145499 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 IEP mRNA:decreased expression:lung (rat) RGD PMID:19823174 RGD:4145499 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase IEP mRNA, protein:increased expression:lung RGD PMID:24657469 RGD:11667099 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Il6 interleukin 6 ameliorates IMP RGD PMID:38602915 RGD:407450417 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6em1Yona interleukin 6; CRISPR/Cas9 induced mutant 1, Yona ameliorates IMP RGD PMID:38602915 RGD:407450417
G Mfn2 mitofusin 2 IEP mRNA, protein:decreased expression:lung (rat) RGD PMID:26485208 RGD:12910856 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Nog noggin IEP mRNA,protein:decreased expression:lung: RGD PMID:25740156 RGD:12801489 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339 		JBrowse link
G Nos3 nitric oxide synthase 3 IEP mRNA,protein:increased expression:pulmonary artery RGD PMID:9950873 RGD:11533933 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Pcna proliferating cell nuclear antigen IEP protein:increased expression:lung (rat) RGD PMID:26485208 RGD:12910856 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Ptgis prostaglandin I2 synthase treatment IEP RGD PMID:12062720 RGD:401959327 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D IEP mRNA, protein:decreased expression:pulmonary artery (rat) RGD PMID:35848503 RGD:401976433 NCBI chr 5:90,046,993...90,698,977
NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396 		JBrowse link
G Slc39a12 solute carrier family 39 member 12 severity IMP RGD PMID:26258299 PMID:26258299 RGD:10401832, RGD:10401832 NCBI chr17:77,353,761...77,440,384
Ensembl chr17:77,353,805...77,440,353 		JBrowse link
G Slc39a12em77Tja solute carrier family 39 (zinc transporter), member 12; zinc finger nuclease induced mutant 77, Timothy J. Aitman severity IMP RGD PMID:26258299 PMID:26258299 RGD:10401832, RGD:10401832
G Sox17 SRY-box transcription factor 17 exacerbates ISO protein:decreased expression:pulmonary artery endothelium (mouse) RGD PMID:37066790 PMID:36919784 PMID:36205124 PMID:36913491 RGD:329853316, RGD:329853737, RGD:329853734, RGD:329853317 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 IDA protein:increased phosphorylation:lung RGD PMID:38602915 RGD:407450417 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19099
    disease of anatomical entity 18440
      respiratory system disease 5241
        lower respiratory tract disease 2357
          lung disease 2318
            pulmonary hypertension 420
              Pulmonary Hypertension, Hypoxia-Induced 30
Path 2
Term Annotations click to browse term
  disease 19099
    disease of anatomical entity 18440
      cardiovascular system disease 5538
        vascular disease 4020
          artery disease 2854
            hypertension 1628
              pulmonary hypertension 420
                Pulmonary Hypertension, Hypoxia-Induced 30
paths to the root