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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Endotoxemia
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Accession:DOID:9005930 term browser browse the term
Definition:A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
Synonyms:exact_synonym: Endotoxemias
 primary_id: MESH:D019446


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Endotoxemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 IEP RGD PMID:9828229 RGD:1598596 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A IEP mRNA:decreased expression:liver (rat) RGD PMID:26977098 RGD:11041000 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B IEP
ISO 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20300455 PMID:9828229 RGD:1598596 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 IEP RGD PMID:16572733 RGD:1598611 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 IEP RGD PMID:17285300 RGD:2301914 NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:105,734,992...105,815,982 		JBrowse link
G Ace angiotensin I converting enzyme IEP associated with Hemorrhage;protein:decreased activity:plasma (rat) RGD PMID:3028670 RGD:8142370 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Ache acetylcholinesterase ISO RGD PMID:17657467 RGD:5688055 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 IEP RGD PMID:11680626 RGD:1598729 NCBI chr 3:121,266,291...121,271,827
Ensembl chr 3:121,266,291...121,271,827 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 IEP protein:increased expression:plasma, spleen RGD PMID:23025351 RGD:9681752 NCBI chr11:38,418,565...38,427,384
Ensembl chr11:38,418,101...38,427,390 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing IEP associated with Obesity RGD PMID:23838384 RGD:8695926 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Adipor2 adiponectin receptor 2 severity IEP associated with obesity;mRNA:decreased expression:liver (rat) RGD PMID:23838384 RGD:8695926 NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:154,172,567...154,231,666 		JBrowse link
G Adra2a adrenoceptor alpha 2A onset IEP mRNA:increased expression:spleen RGD PMID:20302880 RGD:6480487 NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:263,065,278...263,069,871 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 IEP protein:decreased expression:kidney RGD PMID:16725227 RGD:6903849 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:116,913,656...116,918,745 		JBrowse link
G Ahr aryl hydrocarbon receptor severity ISO RGD PMID:24930766 RGD:39939032 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Akp3 alkaline phosphatase 3, intestine, not Mn requiring ISO RGD PMID:23569246 RGD:14349049 NCBI chr 9:95,252,581...95,256,616
Ensembl chr 9:95,248,840...95,256,616 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 IEP RGD PMID:22824368 RGD:38676479 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A IEP RGD PMID:16930621 RGD:1599054 NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15328337 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126 		JBrowse link
G Alpp alkaline phosphatase, placental ISO RGD PMID:23569246 RGD:14349049 NCBI chr 9:95,213,763...95,216,509
Ensembl chr 9:95,213,374...95,219,451 		JBrowse link
G Apoa1 apolipoprotein A1 treatment ISO
IDA 		RGD PMID:18593575 PMID:23227448 RGD:7241573, RGD:7241868 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729 		JBrowse link
G Apob apolipoprotein B IEP RGD PMID:16719989 RGD:1599165 NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814 		JBrowse link
G Apoe apolipoprotein E ISO rat model treated with human protein RGD PMID:9153287 RGD:6904216 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855 		JBrowse link
G Asl argininosuccinate lyase IEP RGD PMID:10652239 RGD:1599265 NCBI chr12:32,295,779...32,313,257
Ensembl chr12:32,295,633...32,317,261 		JBrowse link
G Ass1 argininosuccinate synthase 1 IEP RGD PMID:10652239 RGD:1599265 NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:35,144,999...35,194,627 		JBrowse link
G Atf2 activating transcription factor 2 treatment IEP
IDA 		protein:increased expression, increased activity:small intestine mucosa RGD PMID:21641970 PMID:24312512 RGD:5135029, RGD:10047418 NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator IEP mRNA:increased expression:diaphragm RGD PMID:23940949 RGD:10054120 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bche butyrylcholinesterase ISO RGD PMID:17657467 RGD:5688055 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760 		JBrowse link
G Bcl2 BCL2, apoptosis regulator IEP mRNA:decreased expression:diaphragm RGD PMID:23940949 RGD:10054120 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G C5ar1 complement C5a receptor 1 IEP mRNA:increased expression:lung RGD PMID:9272704 RGD:70679 NCBI chr 1:86,077,309...86,088,001 JBrowse link
G Casp1 caspase 1 IMP RGD PMID:17384935 RGD:2315892 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Casp3 caspase 3 IEP mRNA:increased expression:diaphragm RGD PMID:23940949 RGD:10054120 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 ISO RGD PMID:19168786 RGD:5684539 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp9 caspase 9 treatment IEP RGD PMID:23214195 RGD:10400903 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cbs cystathionine beta synthase severity ISO
IEP 		Protein:increased expression:spleen, lung (mouse)
mRNA:increased expression:liver (rat) 		RGD PMID:27748832 PMID:27748832 PMID:24702258 PMID:16100527 RGD:40903019, RGD:40903019, RGD:40903035, RGD:40903049 NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,709,395...9,734,066 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP protein:increased expression:plasma RGD PMID:19060786 RGD:2307004 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP protein:increased expression:plasma RGD PMID:16215387 RGD:2307171 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 ISO RGD PMID:17016504 RGD:5688178 NCBI chr 8:132,433,711...132,439,266
Ensembl chr 8:132,431,592...132,439,374 		JBrowse link
G Cd14 CD14 molecule IEP protein:increased expression:liver, endothelial cell of sinusoid RGD PMID:12046090 RGD:724637 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292 		JBrowse link
G Cd40 CD40 molecule ISO protein:decreased nitrosylation:macrophage RGD PMID:20473113 RGD:5490974 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta treatment IEP
ISO 		RGD PMID:15192048 PMID:14659593 RGD:1625687, RGD:40903034 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:76,000,754...76,186,734 		JBrowse link
G Cs citrate synthase IEP protein:increased expression:gastrocnemius RGD PMID:25674200 RGD:329337350 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938 		JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:9514298 RGD:11039535 NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 IEP protein:increased expression:atrium endocardium RGD PMID:19282612 RGD:4891965 NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 ISO mRNA:increased expression:multiple organs RGD PMID:9766630 RGD:5135254 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 ISO mRNA:increased expression:multiple organs RGD PMID:9766630 RGD:5135254 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 ISO mRNA:increased expression:multiple organs RGD PMID:9766630 RGD:5135254 NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,594,959...17,596,417 		JBrowse link
G Edn1 endothelin 1 IEP mRNA, protein:increased expression:liver (rat) RGD PMID:11206318 RGD:8662297 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Ep300 E1A binding protein p300 IEP associated with Kidney Reperfusion Injury; protein:altered localization:kidney (rat) RGD PMID:23936185 RGD:7257563 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574 		JBrowse link
G Ephx2 epoxide hydrolase 2 ISO RGD PMID:19154430 RGD:5688360 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:23214195 RGD:10400903 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725 		JBrowse link
G F12 coagulation factor XII IEP RGD PMID:11092686 RGD:7394782 NCBI chr17:9,212,819...9,220,664
Ensembl chr17:9,212,819...9,220,664 		JBrowse link
G F2 coagulation factor II, thrombin treatment
severity 		IDA
ISO
IEP 		associated with liver cirrhosis;protein:increased expression:blood plasma (human)
associated with liver cirrhosis;protein:increased expression:plasma (human) 		RGD PMID:21396682 PMID:10604885 PMID:7615203 PMID:10887118 PMID:9863491 More... RGD:5147765, RGD:40818436, RGD:14974253, RGD:40818427, RGD:14401592, RGD:10449434, RGD:6893482, RGD:5147779 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246 		JBrowse link
G F3 coagulation factor III, tissue factor treatment IDA
ISO 		associated with Protein C Deficiency RGD PMID:21396682 PMID:8956768 PMID:20858853 RGD:5147765, RGD:11340208, RGD:11341685 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369 		JBrowse link
G F5 coagulation factor V IEP RGD PMID:11092686 RGD:7394782 NCBI chr13:79,046,657...79,116,247
Ensembl chr13:79,046,448...79,116,247 		JBrowse link
G F7 coagulation factor VII treatment IEP
ISO 		RGD PMID:11092686 PMID:16378835 RGD:7394782, RGD:11041650 NCBI chr16:83,191,896...83,202,775
Ensembl chr16:83,191,914...83,202,738 		JBrowse link
G F8 coagulation factor VIII IEP RGD PMID:11092686 RGD:7394782 NCBI chr18:155,237...187,186
Ensembl chr18:155,309...186,683 		JBrowse link
G Fas Fas cell surface death receptor IEP mRNA, protein:increased expression:spleen (rat) RGD PMID:20428798 RGD:8662930 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Fga fibrinogen alpha chain treatment IDA RGD PMID:19295478 RGD:11040925 NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577 		JBrowse link
G Foxp3 forkhead box P3 IEP protein:increased expression:intestinal mucosa RGD PMID:19998507 RGD:38455980 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:17,580,380...17,595,894 		JBrowse link
G Gch1 GTP cyclohydrolase 1 treatment IEP mRNA:increased expression:lung
associated with liver cirrhosis 		RGD PMID:9388472 PMID:16845913 PMID:14647062 RGD:329961576, RGD:401793756, RGD:401700399 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:22,884,006...22,917,412 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration IEP RGD PMID:23073658 RGD:9685733 NCBI chr10:14,223,023...14,225,736
Ensembl chr10:14,223,023...14,225,935 		JBrowse link
G Ghr growth hormone receptor IEP mRNA:decreased expression:liver RGD PMID:12654216 PMID:12217886 RGD:2307380, RGD:625688 NCBI chr 2:54,269,066...54,532,595
Ensembl chr 2:54,270,206...54,532,331 		JBrowse link
G Gpt glutamic--pyruvic transaminase treatment IEP RGD PMID:25514429 RGD:401717525 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gsr glutathione-disulfide reductase treatment IEP RGD PMID:25469663 RGD:10401928 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Hmgb1 high mobility group box 1 IEP protein:increased expression:heart, serum RGD PMID:18503231 RGD:10402065 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Hmox1 heme oxygenase 1 treatment IEP RGD PMID:21396999 RGD:10755715 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hsf1 heat shock transcription factor 1 treatment IDA RGD PMID:25571843 RGD:10402404 NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 IEP
ISO 		mRNA, protein:increased expression:medulla oblongata
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:16741687 PMID:16675490 RGD:1624232 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP protein:increased expression:lung (rat) RGD PMID:19776691 RGD:4145502 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 ISO RGD PMID:24930766 PMID:28077574 RGD:39939032, RGD:39939117 NCBI chr16:74,133,259...74,145,328
Ensembl chr16:74,133,259...74,145,328 		JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 ISO RGD PMID:24930766 RGD:39939032 NCBI chr16:74,161,761...74,200,651
Ensembl chr16:74,161,774...74,200,650 		JBrowse link
G Ifng interferon gamma IEP protein:increased expression:serum: RGD PMID:9195172 RGD:10755747 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Igf1 insulin-like growth factor 1 IEP mRNA, protein:decreased expression:liver, serum RGD PMID:18492809 PMID:12217886 RGD:10402757, RGD:625688 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764 		JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit IEP RGD PMID:12217886 RGD:625688 NCBI chr10:14,397,076...14,408,439
Ensembl chr10:14,403,399...14,407,138 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 IEP RGD PMID:12217886 RGD:625688 NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 IEP mRNA, protein:decreased expression:liver, serum RGD PMID:18492809 RGD:10402757 NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 IEP RGD PMID:12217886 RGD:625688 NCBI chr 9:81,901,605...81,914,187
Ensembl chr 9:81,897,616...81,914,390 		JBrowse link
G Il10 interleukin 10 treatment IEP
ISO 		protein:increased expression:plasma RGD PMID:19302852 PMID:28664613 PMID:27943364 RGD:2311055, RGD:14975137, RGD:14975170 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il13 interleukin 13 treatment ISO RGD PMID:10674721 RGD:8549626 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il1a interleukin 1 alpha ISO
IEP 		protein:increased expression:plasma RGD PMID:9636192 PMID:22426124 RGD:6907109, RGD:7794786 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta IEP protein:increased expression:plasma RGD PMID:17201737 RGD:1626625 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment IEP
ISO 		mRNA:increased expression:lung, spleen, liver (rat) RGD PMID:1385928 PMID:8855299 RGD:8551846, RGD:11522760 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il6 interleukin 6 IDA
IEP 		associated with Diabetes Mellitus, Experimental; Protein:increased expression:extracellular space (rat)
protein:increased expression:serum (rat)
protein:increased expression:plasma, pituitary, adrenal, spleen 		RGD PMID:19449282 PMID:21396682 PMID:22227956 PMID:10235303 RGD:2307179, RGD:5147765, RGD:6893482, RGD:598148179 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 ISO mRNA, protein:increased expression:blood (human) RGD PMID:17982103 RGD:36049802 NCBI chr 7:57,538,522...57,600,166
Ensembl chr 7:57,539,557...57,598,706 		JBrowse link
G Irs1 insulin receptor substrate 1 ISO protein:increased tyrosine nitration, decreased tyrosine phosphorylation:skeletal muscle RGD PMID:21206533 RGD:6483008 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538 		JBrowse link
G Itga2b integrin subunit alpha 2b IMP RGD PMID:15280099 RGD:2316360 NCBI chr10:87,908,697...87,926,225
Ensembl chr10:87,908,697...87,925,833 		JBrowse link
G Itgb3 integrin subunit beta 3 IMP RGD PMID:15280099 RGD:2316360 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 ISO RGD PMID:22609006 RGD:6892951 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042 		JBrowse link
G Lbp lipopolysaccharide binding protein treatment IEP
ISO 		mRNA:increased expression:hepatocyte RGD PMID:8418776 PMID:8593028 PMID:16307218 RGD:9685191, RGD:9685196, RGD:9685193 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518 		JBrowse link
G Lcn2 lipocalin 2 ISO mRNA:increased expression:brain,liver RGD PMID:21943033 RGD:126779582 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Map2 microtubule-associated protein 2 ISO mRNA, protein:decreased expression:neuron RGD PMID:21421895 RGD:6483086 NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 treatment IEP
IDA 		protein:increased activity:small intestine mucosa RGD PMID:21641970 PMID:24312512 RGD:5135029, RGD:10047418 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEP protein:increased phophorylation:hippocampus (rat) RGD PMID:12207162 RGD:150340687 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mc4r melanocortin 4 receptor IEP mRNA:increased expression:paraventricular nucleus (rat) RGD PMID:21343543 RGD:6484214 NCBI chr18:62,689,798...62,691,685 JBrowse link
G Mif macrophage migration inhibitory factor IEP protein:increased expression:plasma RGD PMID:16601957 RGD:1641983 NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121 		JBrowse link
G Mir146a microRNA 146a treatment ISO miRNA:increased expression:spleen (mouse) RGD PMID:30867482 RGD:34888227 NCBI chr10:28,349,996...28,350,090 JBrowse link
G Mir155 microRNA 155 treatment ISO associated with familial hyperlipidemia RGD PMID:28970282 PMID:28264607 PMID:29079998 PMID:29979224 RGD:21079445, RGD:24922204, RGD:21081539, RGD:21081538 NCBI chr11:37,261,114...37,261,178
Ensembl chr11:37,261,114...37,261,178 		JBrowse link
G Mme membrane metallo-endopeptidase severity IMP RGD PMID:11078421 RGD:13801040 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463 		JBrowse link
G Mmp3 matrix metallopeptidase 3 IEP RGD PMID:17083784 RGD:2290426 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826 		JBrowse link
G Mt2 metallothionein 2 IEP mRNA:increased expression:liver (rat) RGD PMID:22100509 RGD:6483852 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709 		JBrowse link
G Mt3 metallothionein 3 IEP RGD PMID:12135776 RGD:10412330 NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming IEP RGD PMID:19099858 RGD:7349370 NCBI chr 1:206,225,775...206,261,280
Ensembl chr 1:206,229,035...206,261,280 		JBrowse link
G Myh6 myosin heavy chain 6 IEP RGD PMID:7874842 RGD:12792976 NCBI chr15:32,388,102...32,413,663
Ensembl chr15:32,387,487...32,411,333 		JBrowse link
G Myh7 myosin heavy chain 7 IEP RGD PMID:7874842 RGD:12792976 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 treatment IEP RGD PMID:26646455 RGD:42722616 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkbia NFKB inhibitor alpha exacerbates
treatment 		ISO RGD PMID:19098124 PMID:10229101 RGD:126908017, RGD:126928139 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos2 nitric oxide synthase 2 IEP
IDA
ISO 		mRNA, protein:increased expression:intestine
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:12620498 PMID:16787348 PMID:20519137 RGD:4891470, RGD:5147779 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 IEP protein:increased expression:aorta (rat) RGD PMID:10462376 RGD:7794732 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Npy neuropeptide Y treatment IDA RGD PMID:15342191 RGD:1580787 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IDA RGD PMID:15640646 RGD:4892561 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Otc ornithine transcarbamylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr  X:15,126,358...15,202,473
Ensembl chr  X:15,126,358...15,239,555 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 IEP RGD PMID:19268478 PMID:12217886 RGD:10427879, RGD:625688 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) IEP mRNA,protein:decreased expression,decreased activity:liver: RGD PMID:19268478 RGD:10427879 NCBI chr15:32,997,853...33,006,691
Ensembl chr15:32,997,834...33,016,864 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 IEP RGD PMID:16337011 RGD:6483567 NCBI chr 2:6,130,045...6,176,974
Ensembl chr 2:6,129,592...6,176,974 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 IEP RGD PMID:16337011 RGD:6483567 NCBI chr 3:151,333,938...151,636,628
Ensembl chr 3:151,333,234...151,638,849 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:22119535 RGD:6771174 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839 		JBrowse link
G Pf4 platelet factor 4 treatment IEP RGD PMID:20601223 RGD:329901905 NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,582,477...17,583,392 		JBrowse link
G Pgf placental growth factor ISO protein:increased expression:multiple RGD PMID:16702604 RGD:6483601 NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:110,547,153...110,557,747 		JBrowse link
G Pla2g7 phospholipase A2 group VII IEP protein:increased expression: : RGD PMID:10748027 RGD:7248791 NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:24,859,502...24,901,747 		JBrowse link
G Plat plasminogen activator, tissue type treatment ISO RGD PMID:9091588 RGD:11541073 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma IEP protein:increased expression:small intestine mucosa RGD PMID:21641970 RGD:5135029 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 ISO mRNA:decreased expression:epididymal fat pad RGD PMID:20421294 RGD:6484543 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO protein:increased expression:liver, mitochondrion (mouse) RGD PMID:28615325 RGD:13432559 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:18205901 PMID:23170801 RGD:11100030, RGD:11100034 NCBI chr18:24,038,596...24,049,061
Ensembl chr18:24,038,597...24,048,964 		JBrowse link
G Ptafr platelet-activating factor receptor treatment IMP RGD PMID:2178565 RGD:10041063 NCBI chr 5:150,049,322...150,079,060
Ensembl chr 5:150,049,460...150,079,408 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IEP protein:increased expression:paraventricular hypothalamic nucleus parvicellular division (rat) RGD PMID:11058222 RGD:10043329 NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:56,062,890...56,074,135 		JBrowse link
G Ptgis prostaglandin I2 synthase treatment IMP RGD PMID:11076704 RGD:401960076 NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IEP RGD PMID:21641970 RGD:5135029 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ren renin ISO
IEP 		protein:increased activity:blood plasma (mouse)
protein:increased activity:blood plasma (rat) 		RGD PMID:30027346 PMID:16512638 RGD:125097481, RGD:125097499 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Serpinc1 serpin family C member 1 treatment ISO
IDA
IEP 		RGD PMID:16457847 PMID:21396682 PMID:20519137 PMID:15995859 RGD:1599326, RGD:5147765, RGD:5147779, RGD:1599332 NCBI chr13:75,790,558...75,804,826
Ensembl chr13:75,790,546...75,817,643 		JBrowse link
G Serpine1 serpin family E member 1 treatment IEP
IDA 		RGD PMID:21396682 PMID:25396762 RGD:5147765, RGD:10449434 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Serpinf1 serpin family F member 1 ISO protein:increased expression:plasma (human) RGD PMID:12386642 RGD:36174005 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,748,506...60,760,898 		JBrowse link
G Serping1 serpin family G member 1 treatment ISO RGD PMID:18652771 RGD:8661643 NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:90,249,423...90,258,717 		JBrowse link
G Slc18a3 solute carrier family 18 member A3 IEP protein:decreased expression:parietal cortex RGD PMID:17306796 RGD:5686693 NCBI chr16:7,719,953...7,722,814 JBrowse link
G Slc22a1 solute carrier family 22 member 1 treatment IDA RGD PMID:18313662 RGD:7243881 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 treatment IDA RGD PMID:18313662 RGD:7243881 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Slc38a3 solute carrier family 38, member 3 IEP RGD PMID:20036385 RGD:9999227 NCBI chr 8:117,202,534...117,220,310
Ensembl chr 8:117,202,536...117,218,630 		JBrowse link
G Slc38a5 solute carrier family 38, member 5 IEP RGD PMID:20036385 RGD:9999227 NCBI chr  X:16,885,701...16,894,470
Ensembl chr  X:16,885,701...16,894,470 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 IEP RGD PMID:26337286 RGD:151361133 NCBI chr19:66,843,808...66,872,412
Ensembl chr19:66,843,808...66,872,412 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor IEP RGD PMID:25466948 RGD:9999425 NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO mRNA:increased expression:liver, skeletal muscle RGD PMID:15169905 RGD:2298923 NCBI chr10:5,389,574...5,391,265
Ensembl chr10:5,389,334...5,391,847 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO
IEP 		mRNA:increased expression:liver, skeletal muscle RGD PMID:15169905 PMID:12217886 RGD:2298923, RGD:625688 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sparc secreted protein acidic and cysteine rich IEP mRNA, protein:decreased expression:kidney RGD PMID:10703670 RGD:2300026 NCBI chr10:40,017,065...40,038,816
Ensembl chr10:40,017,075...40,039,268 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B IDA protein:decreased tyrosine phosphorylation:liver RGD PMID:17327369 RGD:1601383 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990 		JBrowse link
G Tbxa2r thromboxane A2 receptor IDA
IMP 		RGD PMID:15647606 PMID:2580129 RGD:1601450, RGD:11059531 NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:9,034,108...9,038,905 		JBrowse link
G Tbxas1 thromboxane A synthase 1 IDA RGD PMID:15647606 RGD:1601450 NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:68,631,838...68,803,969 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase severity ISO RGD PMID:24930766 RGD:39939032 NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:169,567,654...169,585,586 		JBrowse link
G Tfpi tissue factor pathway inhibitor treatment ISO RGD PMID:17537762 RGD:11062086 NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:89,939,868...89,980,742 		JBrowse link
G Thbd thrombomodulin IEP
ISO 		mRNA:decreased expression:endothelial cell RGD PMID:12611420 PMID:20348393 PMID:19487933 RGD:1601652, RGD:5685037, RGD:5684988 NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:156,306,632...156,320,582 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 IEP RGD PMID:17083784 RGD:2290426 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547 		JBrowse link
G Tlr2 toll-like receptor 2 treatment IDA
ISO 		associated with liver cirrhosis RGD PMID:22172266 PMID:12610323 RGD:7241094, RGD:597538466 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tlr4 toll-like receptor 4 treatment
disease_progression 		IDA
ISO 		mRNA:increased expression:liver: RGD PMID:22172266 PMID:23977376 PMID:23977376 RGD:7241094, RGD:14697731, RGD:14697731 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor treatment IEP
IDA
ISO 		protein:increased expression:plasma
protein:increased expression:plasma (rat)
associated with liver cirrhosis
XCO:0000822 JTE-607 		RGD PMID:17324147 PMID:20519137 PMID:21396682 PMID:12813371 PMID:8283134 More... RGD:4891465, RGD:5147779, RGD:5147765, RGD:14995427, RGD:14995443, RGD:15023464, RGD:38501090, RGD:40903016 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 treatment ISO RGD PMID:21507332 PMID:15585833 RGD:126925982, RGD:126928122 NCBI chr 9:20,259,227...20,276,879
Ensembl chr 9:20,261,408...20,276,892 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 IEP mRNA:increased expression:brain: RGD PMID:20061033 RGD:7240511 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vwf von Willebrand factor IEP protein:increased expression:endothelial cell: RGD PMID:2650559 RGD:11079230 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757 		JBrowse link
endotoxin shock term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gch1 GTP cyclohydrolase 1 treatment IDA RGD PMID:8602831 RGD:329961578 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:22,884,006...22,917,412 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A treatment IMP RGD PMID:19318092 RGD:401901206 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19154
    disease by infectious agent 2257
      Bacterial Infections and Mycoses 1120
        Toxemia 179
          Endotoxemia 161
            endotoxin shock 2
Path 2
Term Annotations click to browse term
  disease 19154
    disease of anatomical entity 18461
      Immune & Inflammatory Diseases 5769
        Inflammation 2851
          Systemic Inflammatory Response Syndrome 399
            Sepsis 397
              bacterial sepsis 177
                Bacteremia 177
                  Endotoxemia 161
                    endotoxin shock 2
paths to the root