RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Pleural Effusion
Accession: DOID:9005883
browse the term
Definition: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.
Synonyms: exact_synonym: Pleural Effusions
primary_id: MESH:D010996 ; RDO:0006358
xref: EFO:0009637
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ACE
angiotensin I converting enzyme
ISO
associated with tuberculosis;protein:increased activity:pleural fluid (human)
RGD
PMID:23091417
RGD:40818411
NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
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ACE2
angiotensin converting enzyme 2
ISO
associated with tuberculosis;protein:decreased activity:pleural fluid (human)
RGD
PMID:23091417
RGD:40818411
NCBI chr X:8,189,267...8,229,415
Ensembl chr X:15,470,896...15,510,891
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ADA
adenosine deaminase
treatment
ISO
RGD
PMID:25547995
RGD:152995274
NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868
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CDKN2A
cyclin dependent kinase inhibitor 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:37441092
NCBI chr 9:21,803,862...21,831,322
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CHRNA1
cholinergic receptor nicotinic alpha 1 subunit
ISO
ClinVar Annotator: match by term: Pleural effusion
ClinVar
PMID:25741868 PMID:28492532 PMID:30177536 PMID:31680349 PMID:36634413
NCBI chr2B:62,022,498...62,039,370
Ensembl chr2B:179,476,677...179,504,763
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FAT4
FAT atypical cadherin 4
ISO
ClinVar Annotator: match by term: Pleural effusion
ClinVar
PMID:25741868 PMID:28492532
NCBI chr 4:117,494,842...117,674,382
Ensembl chr 4:128,637,516...128,814,407
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IL15
interleukin 15
ISO
RGD
PMID:15072171
RGD:4990458
NCBI chr 4:133,693,995...134,115,470
Ensembl chr 4:145,402,111...145,416,622
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LOX
lysyl oxidase
ISO
ClinVar Annotator: match by term: Pleural effusion
ClinVar
PMID:25741868 PMID:28492532
NCBI chr 5:117,450,833...117,464,957
Ensembl chr 5:123,234,662...123,248,717
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NF2
NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:37441092
NCBI chr22:10,648,022...10,738,167
Ensembl chr22:28,454,119...28,544,013
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SRFBP1
serum response factor binding protein 1
ISO
ClinVar Annotator: match by term: Pleural effusion
ClinVar
PMID:25741868 PMID:28492532
NCBI chr 5:117,351,025...117,417,546
Ensembl chr 5:123,134,896...123,196,844
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TNF
tumor necrosis factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:2518282
NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
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TP53
tumor protein p53
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:37441092
NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120
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ADA
adenosine deaminase
disease_progression
ISO
protein:decreased expression:serum: protein:increased activity:serum:
RGD
PMID:1689629 PMID:1818842 PMID:27300446
RGD:152995272 RGD:152995292 RGD:152998934
NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868
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IL10
interleukin 10
ISO
RGD
PMID:30695099
RGD:14975123
NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
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MMP2
matrix metallopeptidase 2
ISO
associated with pleurisy; protein:decreased activity:pleura
RGD
PMID:17611666
RGD:5130711
NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279
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MMP9
matrix metallopeptidase 9
ISO
associated with pleurisy; protein:decreased activity:pleura
RGD
PMID:17611666
RGD:5130711
NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
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