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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Pleural Effusion
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Accession:DOID:9005883 term browser browse the term
Definition:Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.
Synonyms:exact_synonym: Pleural Effusions
 primary_id: MESH:D010996;   RDO:0006358
 xref: EFO:0009637



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Pleural Effusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO associated with tuberculosis;protein:increased activity:pleural fluid (human) RGD PMID:23091417 RGD:40818411 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
JBrowse link
G ACE2 angiotensin converting enzyme 2 ISO associated with tuberculosis;protein:decreased activity:pleural fluid (human) RGD PMID:23091417 RGD:40818411 NCBI chr  X:8,189,267...8,229,415
Ensembl chr  X:15,470,896...15,510,891
JBrowse link
G ADA adenosine deaminase treatment ISO RGD PMID:25547995 RGD:152995274 NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:37441092 NCBI chr 9:21,803,862...21,831,322 JBrowse link
G CHRNA1 cholinergic receptor nicotinic alpha 1 subunit ISO ClinVar Annotator: match by term: Pleural effusion ClinVar PMID:25741868 PMID:28492532 PMID:30177536 PMID:31680349 PMID:36634413 NCBI chr2B:62,022,498...62,039,370
Ensembl chr2B:179,476,677...179,504,763
JBrowse link
G FAT4 FAT atypical cadherin 4 ISO ClinVar Annotator: match by term: Pleural effusion ClinVar PMID:25741868 PMID:28492532 NCBI chr 4:117,494,842...117,674,382
Ensembl chr 4:128,637,516...128,814,407
JBrowse link
G IL15 interleukin 15 ISO RGD PMID:15072171 RGD:4990458 NCBI chr 4:133,693,995...134,115,470
Ensembl chr 4:145,402,111...145,416,622
JBrowse link
G LOX lysyl oxidase ISO ClinVar Annotator: match by term: Pleural effusion ClinVar PMID:25741868 PMID:28492532 NCBI chr 5:117,450,833...117,464,957
Ensembl chr 5:123,234,662...123,248,717
JBrowse link
G NF2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor ISO CTD Direct Evidence: marker/mechanism CTD PMID:37441092 NCBI chr22:10,648,022...10,738,167
Ensembl chr22:28,454,119...28,544,013
JBrowse link
G SRFBP1 serum response factor binding protein 1 ISO ClinVar Annotator: match by term: Pleural effusion ClinVar PMID:25741868 PMID:28492532 NCBI chr 5:117,351,025...117,417,546
Ensembl chr 5:123,134,896...123,196,844
JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: therapeutic CTD PMID:2518282 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G TP53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:37441092 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120
JBrowse link
Malignant Pleural Effusions term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase disease_progression ISO protein:decreased expression:serum:
protein:increased activity:serum:
RGD PMID:1689629 PMID:1818842 PMID:27300446 RGD:152995272 RGD:152995292 RGD:152998934 NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868
JBrowse link
G IL10 interleukin 10 ISO RGD PMID:30695099 RGD:14975123 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
JBrowse link
G MMP2 matrix metallopeptidase 2 ISO associated with pleurisy; protein:decreased activity:pleura RGD PMID:17611666 RGD:5130711 NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO associated with pleurisy; protein:decreased activity:pleura RGD PMID:17611666 RGD:5130711 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15834
    disease of anatomical entity 15490
      respiratory system disease 4888
        lower respiratory tract disease 2204
          pleural disease 114
            Pleural Effusion 15
              Malignant Pleural Effusions 4
paths to the root