RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Pleural Effusion
Accession: DOID:9005883
browse the term
Definition: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.
Synonyms: exact_synonym: Pleural Effusions
primary_id: MESH:D010996 ; RDO:0006358
xref: EFO:0009637
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Ace
angiotensin I converting enzyme
ISO
associated with tuberculosis;protein:increased activity:pleural fluid (human)
RGD
PMID:23091417
RGD:40818411
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Ace2
angiotensin converting enzyme 2
ISO
associated with tuberculosis;protein:decreased activity:pleural fluid (human)
RGD
PMID:23091417
RGD:40818411
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Ada
adenosine deaminase
treatment
ISO
RGD
PMID:25547995
RGD:152995274
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:37441092
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Chrna1
cholinergic receptor nicotinic alpha 1 subunit
ISO
ClinVar Annotator: match by term: Pleural effusion
ClinVar
PMID:25741868 PMID:28492532 PMID:30177536 PMID:31680349 PMID:36634413
NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840
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Fat4
FAT atypical cadherin 4
ISO
ClinVar Annotator: match by term: Pleural effusion
ClinVar
PMID:25741868 PMID:28492532
NCBI chr 2:121,927,266...122,056,700
Ensembl chr 2:121,927,942...122,056,707
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Il15
interleukin 15
ISO
RGD
PMID:15072171
RGD:4990458
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
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Lox
lysyl oxidase
ISO
ClinVar Annotator: match by term: Pleural effusion
ClinVar
PMID:25741868 PMID:28492532
NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
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Nf2
NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:37441092
NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667
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Srfbp1
serum response factor binding protein 1
ISO
ClinVar Annotator: match by term: Pleural effusion
ClinVar
PMID:25741868 PMID:28492532
NCBI chr18:45,920,389...45,945,385
Ensembl chr18:45,920,446...45,942,515
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:2518282
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:37441092
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Ada
adenosine deaminase
disease_progression
ISO
protein:increased activity:serum: protein:decreased expression:serum:
RGD
PMID:27300446 PMID:1818842 PMID:1689629
RGD:152995272 , RGD:152998934 , RGD:152995292
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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Il10
interleukin 10
ISO
RGD
PMID:30695099
RGD:14975123
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Mmp2
matrix metallopeptidase 2
ISO
associated with pleurisy; protein:decreased activity:pleura
RGD
PMID:17611666
RGD:5130711
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
ISO
associated with pleurisy; protein:decreased activity:pleura
RGD
PMID:17611666
RGD:5130711
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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