RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Synonyms:
exact_synonym:
Metachronous Neoplasm; Metachronous Neoplasms; Metachronous Second Primary Neoplasms; Second Cancer; Second Cancers; Second Malignancies; Second Malignancy; Second Neoplasm; Second Neoplasms; Second Primary Cancer; Second Primary Cancers; Second Primary Neoplasm; Therapy Associated Cancer; Therapy Associated Neoplasms; Therapy Related Cancer; Therapy Related Neoplasms; Therapy-Associated Cancers; Therapy-Associated Neoplasm; Therapy-Related Cancers; Therapy-Related Neoplasm; Treatment Associated Cancer; Treatment Associated Neoplasms; Treatment Related Cancer; Treatment Related Neoplasms; Treatment-Associated Cancers; Treatment-Associated Neoplasm; Treatment-Related Cancers; Treatment-Related Neoplasm