Experimental Diabetes Mellitus - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Experimental Diabetes Mellitus	go back to main search page
Accession:	DOID:9005643	browse the term
Definition:	Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
Synonyms:	exact_synonym:	Alloxan Diabetes; Experimental Diabetes Mellitus; Streptozocin Diabete; streptozocin diabetes; streptozotocin diabetes
	primary_id:	MESH:D003921

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Rat (616) Mouse (596) Human (591) Chinchilla (551) Bonobo (577) Dog (579) Squirrel (560) Pig (574) Green Monkey (574) Naked Mole-rat (550) All
Genes (596)

Experimental Diabetes Mellitus

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetoacetyl-CoA synthetase

protein:decreased activity:liver

RGD

NCBI chr 5:125,552,937...125,594,469
Ensembl chr 5:125,552,878...125,594,474

G

arylalkylamine N-acetyltransferase

RGD

NCBI chr11:116,482,547...116,489,022
Ensembl chr11:116,477,258...116,488,506

G

4-aminobutyrate aminotransferase

RGD

NCBI chr16:8,331,293...8,439,432
Ensembl chr16:8,331,293...8,439,432

G

ATP-binding cassette, sub-family B member 1A

disease_progression
treatment

protein: decreased expression
mRNA:increased expression:brain
mRNA:increased expression:ileum, intestinal mucosa (rat)

RGD

PMID:17074306 PMID:17664251 PMID:26460146 PMID:21685928

RGD:1598559, RGD:2312730, RGD:11041112, RGD:8657121

NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575

G

ATP-binding cassette, sub-family B member 1B

disease_progression

mRNA:increased expression:brain
mRNA:increased expression:ileum, intestinal mucosa (rat)

RGD

PMID:17074306 PMID:17664251 PMID:26460146

RGD:1598559, RGD:2312730, RGD:11041112

NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315

G

ATP-binding cassette, sub-family B member 4

RGD

NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231

G

ATP-binding cassette, sub-family member 2

protein: increased expression
mRNA:decreased expression:liver
mRNA: increased expression: brain

RGD

PMID:19356064 PMID:20487213 PMID:17664251

RGD:2312728, RGD:11541075, RGD:2312730

NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179

G

ATP-binding cassette, sub-family C member 3

mRNA:increased expression:liver

RGD

NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823

G

ATP-binding cassette, sub-family C member 9

mRNA, protein:decreased expression:heart

RGD

NCBI chr 6:142,533,592...142,648,472
Ensembl chr 6:142,533,588...142,648,041

G

ATP binding cassette subfamily G member 2 (Junior blood group)

protein:decreased expression:cerebral cortex

RGD

NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661

G

ATP binding cassette subfamily G member 5

RGD

NCBI chr17:84,965,602...84,990,439
Ensembl chr17:84,965,662...84,990,439

G

ATP binding cassette subfamily G member 8

RGD

NCBI chr17:84,983,730...85,007,761
Ensembl chr17:84,983,730...85,007,761

G

acetyl-Coenzyme A acyltransferase 1A

mRNA:increased expression: heart

RGD

NCBI chr 9:119,170,113...119,179,361
Ensembl chr 9:119,168,742...119,179,365

G

acyl-Coenzyme A dehydrogenase, very long chain

protein:decreased expression:brain

RGD

NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237

G

angiotensin I converting enzyme

protein:increased expression:kidney
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:22191573 PMID:18679036

NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790

G

angiotensin converting enzyme 2

protein:altered expression:kidney

RGD

NCBI chr X:162,922,338...162,971,414
Ensembl chr X:162,922,328...162,971,416

G

acetylcholinesterase

treatment

protein:increased expression:blood

RGD

PMID:19296211 PMID:1385785 PMID:19347982 PMID:19303406

RGD:2312432, RGD:2312437, RGD:150517552, RGD:2312430

NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728

G

amino carboxymuconate semialdehyde decarboxylase

treatment

RGD

PMID:12042425 PMID:19169727

RGD:13831125, RGD:13831126

NCBI chr 1:127,657,149...127,695,723
Ensembl chr 1:127,657,150...127,695,715

G

acyl-CoA thioesterase 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:84,056,276...84,064,444
Ensembl chr12:84,056,264...84,065,145

G

acyl-CoA thioesterase 2

protein:increased expression:heart, mitochondrion (rat)

RGD

NCBI chr12:84,034,635...84,040,651
Ensembl chr12:84,034,635...84,040,647

G

acyl-Coenzyme A oxidase 1, palmitoyl

CTD Direct Evidence: marker/mechanism

NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871

G

acid phosphatase 5, tartrate resistant

protein:increased activity:femoral bone (rat)

RGD

NCBI chr 9:22,038,023...22,047,042
Ensembl chr 9:22,038,023...22,047,007

G

acyl-CoA synthetase long-chain family member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088

G

acyl-CoA synthetase long-chain family member 3

RGD

NCBI chr 1:78,635,600...78,685,462
Ensembl chr 1:78,635,542...78,685,460

G

acyl-CoA synthetase long-chain family member 6

mRNA:decreased expression:heart

RGD

NCBI chr11:54,194,580...54,255,582
Ensembl chr11:54,194,624...54,255,582

G

adenosine deaminase

protein:increased expression:platelet

RGD

PMID:19166862 PMID:9784839

RGD:2313538, RGD:2313540

NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159

G

adenylate cyclase activating polypeptide 1

protein:increased expression:pancreas, hypothalamus

RGD

NCBI chr17:93,506,448...93,513,967
Ensembl chr17:93,506,445...93,513,965

G

adiponectin, C1Q and collagen domain containing

mRNA, protein:decreased expression:adipose tissue, serum
protein:increased expression:retina

RGD

PMID:16201273 PMID:23174569

RGD:1599146, RGD:8694416

NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778

G

adiponectin receptor 2

no_association

No change in Adipor2 expression in rat heart in streptozotocin induced diabetic rats
Reduced Adipor2 mRNA in livers of diabetic mice
High fat induced diabetes

RGD

PMID:17884446 PMID:18222103 PMID:19220660

RGD:2312495, RGD:2312488, RGD:2312478

NCBI chr 6:119,330,111...119,394,489
Ensembl chr 6:119,330,111...119,394,665

G

adenosine kinase

protein:decreased expression:spleen, lymphocyte

RGD

NCBI chr14:21,102,622...21,498,637
Ensembl chr14:21,102,642...21,498,637

G

adrenomedullin

protein:increased expression:pigmented epithelial cell, retina

RGD

NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027

G

adenosine A1 receptor

treatment

protein:decreased expression:hippocampus
associated with hypertension

RGD

PMID:16256246 PMID:9597368 PMID:19276628 PMID:11593763

RGD:2313805, RGD:1625365, RGD:2313804, RGD:2313808

NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169

G

adenosine A2a receptor

protein:increased expression:hippocampus

RGD

NCBI chr10:75,152,711...75,170,626
Ensembl chr10:75,152,711...75,170,618

G

adrenergic receptor, alpha 1a

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:19133277 PMID:17054657

NCBI chr14:66,872,705...67,009,549
Ensembl chr14:66,872,700...67,008,617

G

adrenergic receptor, beta 1

protein:decreased expression:left ventricle muscular part

RGD

NCBI chr19:56,710,549...56,713,582
Ensembl chr19:56,710,631...56,721,545

G

adrenergic receptor, beta 3

protein:increased expression:left ventricle muscular part
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17622774 PMID:21054861

NCBI chr 8:27,715,804...27,720,833
Ensembl chr 8:27,715,804...27,740,644

G

adenylosuccinate lyase

protein:increased activity:heart (rat)

RGD

NCBI chr15:80,832,691...80,855,148
Ensembl chr15:80,832,691...80,855,147

G

adenylosuccinate synthase 1

protein:increased activity:heart (rat)

RGD

NCBI chr12:112,586,481...112,607,789
Ensembl chr12:112,586,479...112,607,794

G

advanced glycosylation end product-specific receptor

treatment

protein:increased expression:lacrimal gland
mRNA:increased expression:renal cortex (mouse)

RGD

PMID:16283249 PMID:22476978 PMID:21458563 PMID:20801062

RGD:1625335, RGD:7245558, RGD:7244188, RGD:7243964

NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910

G

angiotensinogen

CTD Direct Evidence: marker/mechanism

PMID:15831366 PMID:17177138 PMID:18829990

NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445

G

angiotensin II receptor, type 2

mRNA, protein:decreased expression:kidney

RGD

NCBI chr X:21,350,863...21,355,072
Ensembl chr X:21,350,783...21,355,403

G

apoptosis-inducing factor, mitochondrion-associated 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440

G

autoimmune regulator

susceptibility

RGD

NCBI chr10:77,865,856...77,879,444
Ensembl chr10:77,865,856...77,879,444

G

aldo-keto reductase family 1 member B

mRNA:increased expression:kidney (rat)

RGD

NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413

G

thymoma viral proto-oncogene 1

treatment

protein:decreased serine phosphorylation:cornea
protein:increased serine phosphorylation:cortex of kidney

RGD

PMID:21330660 PMID:29379801 PMID:18599524

RGD:5131482, RGD:408346751, RGD:8657153

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

aminolevulinate, delta-, dehydratase

susceptibility
treatment

protein:decreased activity:liver, kidney (rat)
protein:decreased activity:liver, erythrocyte (rat)
protein:decreased activity:blood, liver

RGD

PMID:19043199 PMID:10224671 PMID:18668330 PMID:21864646 PMID:24947461 More...

RGD:4144150, RGD:15039405, RGD:12904704, RGD:12904702, RGD:12904692, RGD:12904683

NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155

G

aminolevulinic acid synthase 1

protein:decreased activity:liver (rat)

RGD

NCBI chr 9:106,110,654...106,125,153
Ensembl chr 9:106,110,654...106,125,853

G

aldolase B, fructose-bisphosphate

mRNA:reduced expression:liver, small intestine (rat)

RGD

NCBI chr 4:49,535,993...49,549,546
Ensembl chr 4:49,535,995...49,549,546

G

angiopoietin 1

protein:increased expression:retina

RGD

PMID:15047628 PMID:17294737

RGD:2313817, RGD:1626163

NCBI chr15:42,288,063...42,540,373
Ensembl chr15:42,288,119...42,540,373

G

angiopoietin 2

protein:increased expression:retina

RGD

NCBI chr 8:18,740,279...18,791,578
Ensembl chr 8:18,740,279...18,791,578

G

angiopoietin-like 3

protein:increased expression:liver

RGD

NCBI chr 4:98,919,191...98,926,429
Ensembl chr 4:98,919,191...98,934,348

G

annexin A1

protein:increased glycation:respiratory system blood vessel endothelium

RGD

NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308

G

annexin A2

protein:increased glycation:respiratory system blood vessel endothelium

RGD

NCBI chr 9:69,360,978...69,399,074
Ensembl chr 9:69,360,902...69,399,077

G

amine oxidase, copper-containing 1

RGD

NCBI chr 6:48,872,189...48,886,122
Ensembl chr 6:48,849,830...48,886,122

G

amine oxidase, copper containing 3

protein:increased expression:kidney, serum
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:14977883 PMID:2218072 PMID:19635478 PMID:12606817

RGD:2313828, RGD:2313819, RGD:2313824

NCBI chr11:101,221,432...101,230,256
Ensembl chr11:101,221,431...101,232,764

G

apolipoprotein A-I

treatment

RGD

NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764

G

apolipoprotein B

RGD

NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835

G

apolipoprotein E

protein:decreased expression:plasma (rat)

RGD

NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113

G

apolipoprotein M

protein:decreased secretion:plasma

RGD

NCBI chr17:35,347,973...35,350,777
Ensembl chr17:35,347,973...35,351,026

G

adenine phosphoribosyl transferase

protein:decreased activity:mammary gland (rat)

RGD

NCBI chr 8:123,301,376...123,303,646
Ensembl chr 8:123,301,374...123,303,648

G

aquaporin 1

protein:increased expression:retina

RGD

NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540

G

aquaporin 2

protein:increased expression:Kidney Medulla
protein:decreased expression:kidney collecting duct

RGD

PMID:11380083 PMID:15705184

RGD:2314347, RGD:2314326

NCBI chr15:99,476,937...99,482,426
Ensembl chr15:99,476,936...99,482,428

G

aquaporin 4

mRNA,protein:increased expression:retina:

RGD

NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039

G

androgen receptor

treatment

protein:decreased expression:pancreatic B cell
mRNA, protein:decreased expression:epididymis, prostate gland, testis

RGD

PMID:18543106 PMID:31838605 PMID:16398356

RGD:2306772, RGD:407424618, RGD:2306774

NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821

G

arginase, liver

protein:increased expression:aorta, liver (rat)

RGD

NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382

G

arginase type II

protein:increased activity:kidney (rat)

RGD

NCBI chr12:79,177,562...79,203,075
Ensembl chr12:79,177,551...79,203,075

G

aspartoacylase

protein:increased expression:duodenum, brain

RGD

NCBI chr11:73,195,813...73,217,677
Ensembl chr11:73,195,818...73,220,422

G

argininosuccinate synthetase 1

mRNA, protein:increased expression:aorta (rat)

RGD

NCBI chr 2:31,360,282...31,410,682
Ensembl chr 2:31,360,219...31,410,684

G

activating transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236

G

autophagy related 7

treatment

protein:decreased expression:myocardium

RGD

PMID:24874076 PMID:24993523

RGD:11557993, RGD:11557996

NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575

G

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

RGD

NCBI chr 7:126,045,032...126,062,245
Ensembl chr 7:126,045,030...126,062,280

G

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

protein:increased carbonylation:heart
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16123366 PMID:21300842 PMID:20122173 PMID:28483572

RGD:6904139, RGD:13782130, RGD:12910731

NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288

G

ATPase, Ca++ transporting, ubiquitous

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16123366 PMID:20122173

NCBI chr11:72,851,995...72,883,869
Ensembl chr11:72,851,995...72,883,870

G

ATPase, H+/K+ exchanging, beta polypeptide

RGD

NCBI chr 8:13,436,209...13,446,778
Ensembl chr 8:13,436,205...13,446,825

G

ATP synthase F1 subunit alpha

protein:decreased expression:cerebral cortex, mitochondrion (rat)

RGD

NCBI chr18:77,861,468...77,870,569
Ensembl chr18:77,861,429...77,870,569

G

ATP synthase F1 subunit beta

associated with polycystic ovary syndrome;mRNA, protein:decreased expression:pancreas (rat)

RGD

NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260

G

ATP synthase peripheral stalk subunit d

protein:decreased expression:retina (rat)

RGD

NCBI chr11:115,306,517...115,310,775
Ensembl chr11:115,306,515...115,310,788

G

ATP synthase peripheral stalk subunit F6

treatment

RGD

NCBI chr16:84,624,754...84,632,495
Ensembl chr16:84,624,754...84,632,513

G

arginine vasopressin

mRNA:increased expression:hypothalamus

RGD

NCBI chr 2:130,422,540...130,424,508
Ensembl chr 2:130,422,540...130,424,474

G

BCL2-associated agonist of cell death

protein:increased expression, decreased phosphorylation, altered activity:testis
protein:decreased serine phosphorylation:cornea

RGD

PMID:17870134 PMID:21330660

RGD:2292685, RGD:5131482

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

BCL2-associated X protein

treatment

protein:increased expression:retina
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:23090186 PMID:18991018 PMID:23267840

RGD:2311240, RGD:10054099

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

butyrylcholinesterase

protein:decreased expression:retina

RGD

PMID:11478742 PMID:12379509 PMID:16187484

RGD:2306783, RGD:2306781, RGD:1599458

NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748

G

branched chain ketoacid dehydrogenase E1, alpha polypeptide

protein:increased expression:liver

RGD

NCBI chr 7:25,329,371...25,358,178
Ensembl chr 7:25,329,371...25,358,406

G

branched chain ketoacid dehydrogenase E1, beta polypeptide

Protein:increased expression:liver;

RGD

NCBI chr 9:83,807,190...84,006,293
Ensembl chr 9:83,807,198...84,006,293

G

B cell leukemia/lymphoma 2

mRNA:decreased expression:embryo
CTD Direct Evidence: marker/mechanism
protein:increased expression:retina

CTD
RGD

PMID:16959961 PMID:23090186 PMID:15649569 PMID:18991018

RGD:1599491, RGD:2311240

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

protein:decreased expression, altered activity:testis
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16959961 PMID:17870134

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

3-hydroxybutyrate dehydrogenase, type 1

protein:decreased activity:heart, mitochondrion (rat)

RGD

NCBI chr16:31,241,115...31,277,719
Ensembl chr16:31,241,098...31,277,719

G

bradykinin receptor, beta 1

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:heart

CTD
RGD

PMID:21430409 PMID:12522068 PMID:20092893 PMID:12489796

RGD:704380, RGD:7241569, RGD:704379

NCBI chr12:105,570,350...105,571,770
Ensembl chr12:105,569,344...105,571,687

G

bradykinin receptor, beta 2

protein:increased expression:hindbrain, spinal cord
mRNA:increased expression:heart

RGD

PMID:16138314 PMID:12489796

RGD:4890452, RGD:704379

NCBI chr12:105,529,431...105,561,503
Ensembl chr12:105,529,485...105,561,496

G

brain derived neurotrophic factor

treatment

RGD

PMID:24857910 PMID:30816461

RGD:10059399, RGD:596936233

NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352

G

beclin 1, autophagy related

treatment

RGD

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

bone gamma carboxyglutamate protein

protein:reduced expression:serum (rat)

NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771

G

basic helix-loop-helix ARNT like 1

RGD

NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333

G

bone morphogenetic protein receptor type 2

protein:increased expression:lung

RGD

NCBI chr 1:59,802,721...59,917,240
Ensembl chr 1:59,802,559...59,918,173

G

betacellulin, epidermal growth factor family member

RGD

PMID:14988244 PMID:19819964 PMID:18388935

RGD:1357906, RGD:2313774, RGD:2306965

NCBI chr 5:91,505,120...91,550,853
Ensembl chr 5:91,505,120...91,550,853

G

calcium channel, voltage-dependent, gamma subunit 4

mRNA:decreased expression:sinoatrial node:

RGD

NCBI chr11:107,623,183...107,685,532
Ensembl chr11:107,623,183...107,685,383

G

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

protein:decreased activity:mammary gland (rat)

RGD

NCBI chr 5:31,211,964...31,235,823
Ensembl chr 5:31,212,124...31,235,823

G

calcitonin/calcitonin-related polypeptide, alpha

protein:decreased expression:dorsal root ganglion, neuron
protein:increased expression:penis erectile tissue, seminal vesicle

RGD

PMID:17151309 PMID:19152794

RGD:2314035, RGD:2314033

NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592

G

caldesmon 1

RGD

NCBI chr 6:34,575,433...34,752,404
Ensembl chr 6:34,575,435...34,752,408

G

calpain 10

mRNA, protein:decreased expression:kidney cortex

RGD

NCBI chr 1:92,862,130...92,875,670
Ensembl chr 1:92,862,098...92,875,663

G

calcium regulated heat stable protein 1

treatment

RGD

NCBI chr16:8,476,444...8,490,017
Ensembl chr16:8,476,444...8,490,019

G

caspase 1

mRNA:increased expression:retina

RGD

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

G

caspase 3

treatment

protein:increased activity:hypothalamus
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20654064 PMID:19094082 PMID:28843149

RGD:2311447, RGD:13782300

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 6

protein:increased activity:heart left ventricle

RGD

NCBI chr 3:129,695,064...129,707,761
Ensembl chr 3:129,695,074...129,707,752

G

caspase 8

treatment

protein:increased activity, increased expression:pituitary gland, prolactin secreting cell
protein:increased expression, increased activity:pituitary gland

RGD

PMID:15976052 PMID:28843149 PMID:17563067 PMID:19540304

RGD:2311319, RGD:13782300, RGD:2311429, RGD:2311427

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

protein:increased activity, increased expression:pituitary gland

RGD

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

calsequestrin 1

protein:increased activity:skeletal muscle tissue

RGD

NCBI chr 1:172,037,461...172,047,462
Ensembl chr 1:172,037,461...172,047,435

G

calcium-sensing receptor

protein:increased expression:pancreas, liver, kidney (rat)

RGD

NCBI chr16:36,310,947...36,382,605
Ensembl chr16:36,314,058...36,382,503

G

catalase

associated with alcohol use disorder; protein:decreased activity;testis, epididymis (rat)
CTD Direct Evidence: marker/mechanism|therapeutic

CTD
RGD

PMID:12123627 PMID:15855331 PMID:20709041 PMID:20376213 PMID:25541261

RGD:5130772, RGD:405255664

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

caveolin 1, caveolae protein

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:18266981 PMID:25086377

NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451

G

caveolin 3

CTD Direct Evidence: marker/mechanism

NCBI chr 6:112,436,466...112,449,833
Ensembl chr 6:112,436,466...112,449,833

G

carbonyl reductase 1

protein:decreased expression:pancreas (rat)

RGD

NCBI chr16:93,404,752...93,407,226
Ensembl chr16:93,402,741...93,407,393

G

cholecystokinin

RGD

NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760

G

cholecystokinin B receptor

mRNA, protein:decreased expression:pancreas

RGD

NCBI chr 7:105,075,201...105,085,546
Ensembl chr 7:105,074,938...105,120,105

G

C-C motif chemokine ligand 2

treatment

protein:increased expression:gingiva
protein:increased expression:plasma

RGD

PMID:17876613 PMID:16891764 PMID:18976114

RGD:2306992, RGD:8549535, RGD:2306984

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 20

CTD Direct Evidence: therapeutic

NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888

G

cellular communication network factor 1

mRNA:increased expression:retina (mouse)

RGD

NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736

G

cellular communication network factor 2

mRNA, protein:increased expression:heart, myocardium (rat)
mRNA:increased expression:heart left ventricle (rat)

RGD

PMID:19820199 PMID:19625611

RGD:2314021, RGD:2314487

NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581

G

cyclin A2

RGD

NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299

G

cyclin B1

mRNA:decreased expression:liver (rat)

RGD

NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078

G

cyclin D3

protein:increased expression:kidney, glomerulus

RGD

NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616

G

cyclin T1

mRNA,protein:decreased expression:liver:

RGD

NCBI chr15:98,436,570...98,468,340
Ensembl chr15:98,436,570...98,468,804

G

C-C motif chemokine receptor 5

protein:increased expression:retina

RGD

NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736

G

CD28 antigen

RGD

NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518

G

CD36 molecule

treatment

mRNA:increased expression:multiple organs

RGD

PMID:16838191 PMID:23691525

RGD:2307214, RGD:11041145

NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799

G

CD3 antigen, epsilon polypeptide

RGD

NCBI chr 9:44,910,033...44,920,961
Ensembl chr 9:44,910,038...44,920,925

G

CD40 ligand

treatment

protein:increased expression:platelet (rat)

RGD

PMID:21831422 PMID:19237211

RGD:11352661, RGD:2312338

NCBI chr X:56,257,448...56,269,402
Ensembl chr X:56,257,503...56,269,402

G

CD68 antigen

CTD Direct Evidence: marker/mechanism

NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979

G

CD80 antigen

RGD

NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697

G

CD86 antigen

RGD

NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443

G

cyclin dependent kinase 9

mRNA,protein:decreased expression:liver:

RGD

NCBI chr 2:32,595,794...32,608,098
Ensembl chr 2:32,595,796...32,603,088

G

cyclin dependent kinase inhibitor 1A

protein:increased expression:testes:

RGD

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

carboxyl ester lipase

protein:decreased expression:pancreas,

RGD

NCBI chr 2:28,445,831...28,453,415
Ensembl chr 2:28,445,807...28,453,415

G

complement factor D

protein:decreased expression:serum

RGD

NCBI chr10:79,726,687...79,728,489
Ensembl chr10:79,726,687...79,728,489

G

cystic fibrosis transmembrane conductance regulator

severity

RGD

NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767

G

choline O-acetyltransferase

protein:decreased expression:telencephalon

RGD

NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946

G

cholinergic receptor, muscarinic 2, cardiac

CTD Direct Evidence: marker/mechanism

NCBI chr 6:36,364,928...36,505,573
Ensembl chr 6:36,365,019...36,505,349

G

colipase, pancreatic

RGD

NCBI chr17:28,777,184...28,779,740
Ensembl chr17:28,777,123...28,779,740

G

clusterin

protein:increased expression:retina
protein:increased expression:pancreatic islet

RGD

PMID:12763621 PMID:23351716

RGD:9068392, RGD:9068411

NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996

G

chymase 1, mast cell

protein:increased expression:mesenteric artery, mast cell (rat)

RGD

NCBI chr14:56,178,908...56,182,132
Ensembl chr14:56,178,908...56,182,132

G

cannabinoid receptor 1

protein:increased expression:hypothalamus, striatum

RGD

NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831

G

catechol-O-methyltransferase

protein:decreased expression:liver

RGD

NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602

G

ceruloplasmin

Protein:increased expression:plasma

RGD

NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309

G

carbamoyl-phosphate synthetase 1

protein:increased activity:liver (rat)

RGD

NCBI chr 1:67,151,294...67,270,426
Ensembl chr 1:67,162,185...67,270,418

G

carnitine palmitoyltransferase 1a, liver

CTD Direct Evidence: marker/mechanism

NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733

G

carnitine palmitoyltransferase 1b, muscle

CTD Direct Evidence: marker/mechanism

NCBI chr15:89,300,608...89,310,065
Ensembl chr15:89,300,608...89,310,066

G

corticotropin releasing hormone

mRNA:increased expression:paraventricular hypothalamic nucleus (rat)

RGD

NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560

G

C-reactive protein, pentraxin-related

RGD

PMID:21736771 PMID:21736794

RGD:6482316, RGD:6907422

NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598

G

CREB regulated transcription coactivator 2

RGD

NCBI chr 3:90,161,475...90,171,432
Ensembl chr 3:90,161,470...90,171,432

G

citrate synthase

protein:increased expression:hippocampus
protein decreased expression:heart, soleus

RGD

PMID:21088877 PMID:12077722

RGD:329337352, RGD:329337354

NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348

G

colony stimulating factor 1 (macrophage)

mRNA,protein:increased expression:retina (rat)

RGD

NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785

G

colony stimulating factor 1 receptor

mRNA,protein:increased expression:retina (rat)

RGD

NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221

G

cathepsin B

protein:decreased activity:glomerulus (rat)

RGD

NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372

G

cathepsin C

RGD

NCBI chr 7:87,927,233...87,960,083
Ensembl chr 7:87,927,293...87,960,096

G

cathepsin L

mRNA:increased expression:gastrocnemius muscle (rat)

RGD

NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704

G

C-X3-C motif chemokine ligand 1

mRNA:increased expression:kidney
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20388520 PMID:15153757

NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055

G

C-X3-C motif chemokine receptor 1

mRNA:increased expression:kidney

RGD

NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945

G

C-X-C motif chemokine ligand 10

mRNA:increased expression:pancreatic islet

RGD

NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748

G

C-X-C motif chemokine ligand 12

protein:increased expression:retina

RGD

PMID:18201529 PMID:17878289

RGD:2306555, RGD:2306557

NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328

G

cytochrome b-245, alpha polypeptide

mRNA, protein:increased expression:aorta
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:pancreas:

CTD
RGD

PMID:11812764 PMID:12967931 PMID:20226688 PMID:23905384

RGD:2317852, RGD:11040693

NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669

G

cytochrome b-245, beta polypeptide

mRNA:increased expression:aorta
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:cerebral cortex;associated with reperfusion injury

CTD
RGD

PMID:19478208 PMID:11157681 PMID:15148062

RGD:1599691, RGD:1599683

NCBI chr X:9,301,493...9,354,005
Ensembl chr X:9,301,491...9,354,010

G

cytochrome P450, family 11, subfamily a, polypeptide 1

mRNA:decreased expression:sciatic nerve (rat)

RGD

NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306

G

cytochrome P450, family 11, subfamily b, polypeptide 2

mRNA:increased expression:kidney

RGD

NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,467...74,728,167

G

cytochrome P450, family 19, subfamily a, polypeptide 1

protein:decreased expression:ovary, testis (rat)

RGD

NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394

G

cytochrome P450, family 1, subfamily a, polypeptide 1

protein:increased expression:liver, microsome (rat)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:22342832 PMID:10711628

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 27, subfamily b, polypeptide 1

RGD

NCBI chr10:126,884,115...126,891,897
Ensembl chr10:126,884,119...126,888,875

G

cytochrome P450, family 2, subfamily b, polypeptide 10

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:22342832 PMID:17015271

NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049

G

cytochrome P450, family 2, subfamily b, polypeptide 9

mRNA:increased expression:liver
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:22342832 PMID:11465407

NCBI chr 7:25,872,775...25,910,086
Ensembl chr 7:25,872,836...25,910,086

G

cytochrome P450, family 2, subfamily e, polypeptide 1

mRNA, protein:increased expression:kidney, liver

RGD

PMID:19406192 PMID:12700423

RGD:2313683, RGD:2313685

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

cytochrome P450, family 3, subfamily a, polypeptide 11

CTD Direct Evidence: marker/mechanism

NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774

G

cytochrome P450, family 4, subfamily a, polypeptide 10

CTD Direct Evidence: marker/mechanism

NCBI chr 4:115,375,484...115,390,846
Ensembl chr 4:115,375,461...115,390,846

G

cytochrome P450, family 4, subfamily a, polypeptide 14

CTD Direct Evidence: marker/mechanism

NCBI chr 4:115,343,397...115,353,355
Ensembl chr 4:115,343,397...115,353,339

G

dopamine beta hydroxylase

mRNA, protein:increased expression:adrenal gland (rat)

RGD

NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212

G

decorin

RGD

NCBI chr10:97,315,362...97,354,025
Ensembl chr10:97,315,471...97,354,005

G

defensin beta 1

RGD

NCBI chr 8:22,266,571...22,285,201
Ensembl chr 8:22,266,615...22,285,201

G

dihydroorotate dehydrogenase

protein:decreased activity:mammary gland (rat)

RGD

PMID:1476792 PMID:1723607

RGD:5132591, RGD:11040445

NCBI chr 8:110,319,876...110,335,330
Ensembl chr 8:110,317,975...110,335,305

G

dipeptidylpeptidase 4

RGD

NCBI chr 2:62,160,417...62,242,635
Ensembl chr 2:62,160,417...62,242,575

G

dopamine receptor D1

treatment

protein:decreased activity:striatum (rat)

RGD

PMID:1386820 PMID:20513244

RGD:2311600, RGD:7248621

NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724

G

dopamine receptor D2

protein:altered activity:hypothalamus, pancreatic islet, brainstem (rat)

RGD

NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477

G

dual specificity phosphatase 1

mRNA, protein:decreased expression:ventricle myocardium
mRNA:increased expression:retina

RGD

PMID:17647144 PMID:17063547

RGD:2298672, RGD:7771540

NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102

G

endothelin converting enzyme 1

mRNA:increased expression:thoracic aorta

RGD

NCBI chr 4:137,589,548...137,692,540
Ensembl chr 4:137,589,548...137,692,540

G

endothelin 1

treatment

mRNA:increased expression:heart, kidney, retina (rat)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12458661 PMID:12967931 PMID:18516100 PMID:18351623 PMID:18351623

RGD:2313282, RGD:2312288, RGD:2312288

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

endothelin receptor type A

RGD

NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093

G

eukaryotic translation elongation factor 2

treatment

protein:decreased expression:cardiac muscle:

RGD

NCBI chr10:81,012,465...81,018,343
Ensembl chr10:81,012,465...81,018,332

G

epidermal growth factor receptor

protein:decreased tyrosine phosphorylation:corneal epithelial cell (rat)

RGD

NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158

G

elastin

mRNA:increased expression:bladder:

RGD

NCBI chr 5:134,731,449...134,776,300
Ensembl chr 5:134,731,447...134,776,177

G

enolase 2, gamma neuronal

protein:increased expression:brain

RGD

NCBI chr 6:124,737,018...124,746,489
Ensembl chr 6:124,737,016...124,746,636

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

protein:decreased expression:retina:

RGD

NCBI chr15:54,702,297...54,816,284
Ensembl chr15:54,702,297...54,816,288

G

ectonucleoside triphosphate diphosphohydrolase 1

protein,mRNA:increased expression:glial cell, retina:
protein:enzyme activity:platelet

RGD

PMID:18687327 PMID:17119848

RGD:9685473, RGD:9685486

NCBI chr19:40,600,810...40,730,046
Ensembl chr19:40,600,810...40,730,046

G

E1A binding protein p300

treatment

mRNA:increased expression:heart (rat)
mRNA:increased expression:retina, kidney (mouse)

RGD

PMID:18657544 PMID:22228707 PMID:18351623 PMID:18413674 PMID:18351623

RGD:2312287, RGD:7296926, RGD:2312288, RGD:2312263, RGD:2312288

NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278

G

erythropoietin

mRNA:increased expression:Schwann cell:

RGD

NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504

G

erythropoietin receptor

mRNA:increased expression:Schwann cell:

RGD

NCBI chr 9:21,870,193...21,874,915
Ensembl chr 9:21,870,193...21,874,802

G

excision repair cross-complementing rodent repair deficiency, complementation group 1

treatment

RGD

NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449

G

excision repair cross-complementing rodent repair deficiency, complementation group 4

treatment

RGD

NCBI chr16:12,927,600...12,969,873
Ensembl chr16:12,927,548...12,968,481

G

estrogen receptor 1 (alpha)

protein:decreased expression:vagina,nucleus
protein:decreased expression:penis

RGD

PMID:16734901 PMID:15596216

RGD:2314014, RGD:2306775

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

estrogen related receptor, alpha

CTD Direct Evidence: marker/mechanism

NCBI chr19:6,888,345...6,899,182
Ensembl chr19:6,888,345...6,899,208

G

E26 avian leukemia oncogene 1, 5' domain

protein:increased expression:retina

RGD

NCBI chr 9:32,547,501...32,669,116
Ensembl chr 9:32,547,517...32,669,116

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

protein:increased expression:kidney

RGD

NCBI chr 6:47,507,208...47,613,843
Ensembl chr 6:47,507,073...47,572,275

G

F11 receptor

RGD

NCBI chr 1:171,265,129...171,292,161
Ensembl chr 1:171,265,103...171,292,171

G

coagulation factor II

protein:increased expression:kidney

RGD

NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759

G

coagulation factor III

protein:increased activity:kidney

RGD

NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697

G

coagulation factor VII

protein:decreased activity:plasma (rat)

RGD

PMID:11474472 PMID:16779662

RGD:2312396, RGD:2312313

NCBI chr 8:13,075,499...13,085,809
Ensembl chr 8:13,076,034...13,085,809

G

fatty acid binding protein 3, muscle and heart

mRNA, protein:decreased expression:aorta

RGD

NCBI chr 4:130,202,531...130,209,256
Ensembl chr 4:130,202,388...130,209,256

G

fatty acid binding protein 4, adipocyte

protein:decreased expresssion:fat cell

RGD

NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636

G

fatty acid desaturase 1

mRNA:decreased expression:liver

RGD

NCBI chr19:10,160,245...10,174,238
Ensembl chr19:10,160,252...10,174,241

G

Fas cell surface death receptor

onset

CTD Direct Evidence: marker/mechanism
protein:increased expression:heart ventricle

CTD
RGD

PMID:16123366 PMID:20004692 PMID:19820199

RGD:2315698, RGD:2314021

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

Fas ligand

protein:increased expression:heart ventricle

RGD

NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064

G

fibrillin 1

protein:increased expression:renal glomerulus (rat)

RGD

NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913

G

Fc fragment of IgG binding protein like 1

NCBI chr 7:27,828,891...27,864,236
Ensembl chr 7:27,828,891...27,864,236

G

fibrinogen alpha chain

protein:increased expression:plasma (rat)

RGD

NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934

G

fibroblast growth factor 2

protein:increased expression:vitreous humor

RGD

PMID:12663474 PMID:10792180

RGD:2315880, RGD:8655613

NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257

G

fibroblast growth factor 21

treatment

protein:decreased expression:serum:
CTD Direct Evidence: therapeutic

CTD
RGD

PMID:23499715 PMID:23262585 PMID:25359298 PMID:23262585

RGD:10401916, RGD:10401921, RGD:10401916

NCBI chr 7:45,263,314...45,264,914
Ensembl chr 7:45,263,310...45,264,914

G

FMS-like tyrosine kinase 1

mRNA:decreased expression:skeletal muscle
mRNA:decreased expression:heart

RGD

PMID:16816123 PMID:16741021

RGD:2313725, RGD:2313724

NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821

G

fibronectin 1

treatment

protein:increased expression:kidney

RGD

PMID:22937115 PMID:22228707

RGD:7206838, RGD:7296926

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

forkhead box A2

mRNA:increased expression:kidney cortex

RGD

NCBI chr 2:147,884,797...147,888,889
Ensembl chr 2:147,884,797...147,888,889

G

forkhead box A3

mRNA:increased expression:liver

RGD

NCBI chr 7:18,747,208...18,757,464
Ensembl chr 7:18,747,209...18,757,463

G

forkhead box O3

protein:increased phosphorylation, increased expression:glomerulus, cytoplasm:
CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:liver:

CTD
RGD

PMID:23090186 PMID:23792339 PMID:17082237 PMID:12683947 PMID:17082237

RGD:10402196, RGD:10402199, RGD:10402196

NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751

G

forkhead box P3

treatment

mRNA,protein:increased expression: peripheral blood, spleen, lymphoid node

RGD

PMID:18328191 PMID:32341701

RGD:38599142, RGD:38599143

NCBI chr X:7,445,915...7,461,482
Ensembl chr X:7,439,883...7,461,484

G

fucosidase, alpha-L- 1, tissue

RGD

NCBI chr 4:135,648,037...135,667,611
Ensembl chr 4:135,648,046...135,667,622

G

furin, paired basic amino acid cleaving enzyme

disease_progression

protein:decreased expression:kidney

RGD

NCBI chr 7:80,038,942...80,055,188
Ensembl chr 7:80,038,333...80,055,184

G

glucose-6-phosphatase catalytic subunit 1

treatment

protein:increased activity:liver, kidney

RGD

PMID:16176150 PMID:27366200

RGD:2315960, RGD:14695533

NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729

G

glucose-6-phosphate dehydrogenase X-linked

treatment

protein:decreased expression:liver
protein:increased expression:lens

RGD

PMID:19374864 PMID:25116122 PMID:16718375

RGD:2307337, RGD:10449121, RGD:2307345

NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800

G

gamma-aminobutyric acid type B receptor subunit 1

RGD

NCBI chr17:37,356,888...37,385,197
Ensembl chr17:37,356,858...37,385,959

G

galanin and GMAP prepropeptide

protein:decreased expression:pancreatic islet

RGD

PMID:11489087 PMID:7505518

RGD:2313740, RGD:2313742

NCBI chr19:3,459,915...3,464,544
Ensembl chr19:3,459,915...3,464,544

G

galanin-like peptide

mRNA:increased expression:arcuate nucleus, pars posterior

RGD

PMID:15256810 PMID:16046316

RGD:2313739, RGD:2313737

NCBI chr 7:6,200,089...6,219,136
Ensembl chr 7:6,200,089...6,219,136

G

glyceraldehyde-3-phosphate dehydrogenase

treatment

RGD

NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430

G

GATA binding protein 4

protein:increased serine phosphorylation:heart

RGD

NCBI chr14:63,436,363...63,509,161
Ensembl chr14:63,436,371...63,509,141

G

vitamin D binding protein

protein:decreased expression:serum

RGD

NCBI chr 5:89,565,370...89,605,757
Ensembl chr 5:89,565,381...89,605,757

G

glucagon

treatment

RGD

NCBI chr 2:62,304,874...62,313,997
Ensembl chr 2:62,304,874...62,313,994

G

GTP cyclohydrolase 1

treatment

protein:increased degradation:heart
associated with type 1 diabetes mellitus

RGD

PMID:27295516 PMID:18061195 PMID:18596126

RGD:329961323, RGD:2314434, RGD:401700392

NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870

G

glucokinase

CTD Direct Evidence: marker/mechanism

NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081

G

glucosaminyl (N-acetyl) transferase 1, core 2

mRNA:increased expression:heart

RGD

NCBI chr19:17,303,505...17,350,208
Ensembl chr19:17,303,505...17,350,208

G

glutamine fructose-6-phosphate transaminase 1

protein:decreased expression:epididymal fat pad, liver, skeletal muscle

NCBI chr 6:87,019,828...87,069,189
Ensembl chr 6:87,019,828...87,069,179

G

gamma-glutamyltransferase 1

protein:increased activity:serum

RGD

NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034

G

growth hormone

protein:decreased expression:serum, pituitary gland

RGD

PMID:2931155 PMID:19370419

RGD:2315682, RGD:2315655

NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691

G

growth hormone receptor

RGD

PMID:12529387 PMID:7964296

RGD:2307365, RGD:11567222

NCBI chr15:3,347,237...3,612,834
Ensembl chr15:3,347,242...3,612,974

G

growth hormone releasing hormone

treatment

RGD

NCBI chr 2:157,171,416...157,190,645
Ensembl chr 2:157,171,417...157,189,426

G

growth hormone releasing hormone receptor

RGD

NCBI chr 6:55,353,204...55,365,515
Ensembl chr 6:55,353,280...55,365,515

G

ghrelin

disease_progression

protein:increased expression:plasma

RGD

PMID:18657539 PMID:23965296

RGD:2313750, RGD:12905048

NCBI chr 6:113,693,080...113,696,872
Ensembl chr 6:113,693,080...113,696,841

G

growth hormone secretagogue receptor

mRNA:increased expression:Arcuate nucleus :

RGD

NCBI chr 3:27,425,500...27,433,384
Ensembl chr 3:27,425,500...27,432,159

G

gastric inhibitory polypeptide

mRNA:increased expression:retina (rat)

RGD

NCBI chr11:95,915,358...95,921,657
Ensembl chr11:95,915,371...95,921,657

G

gastric inhibitory polypeptide receptor

mRNA:increased expression:retina (rat)

RGD

NCBI chr 7:18,889,988...18,904,173
Ensembl chr 7:18,889,986...18,900,052

G

gap junction protein, alpha 1

treatment

protein:increased expression:dermis
protein:decreased expression:retina, blood vessel
protein:altered expression:retina:

RGD

PMID:22455314 PMID:20130277 PMID:22110070 PMID:20609064

RGD:7207269, RGD:8662383, RGD:7364887, RGD:7207415

NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609

G

gap junction protein, alpha 5

treatment

RGD

NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732

G

gap junction protein, beta 2

mRNA,protein:decreased expression:retina:

RGD

NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159

G

gap junction protein, beta 6

RGD

NCBI chr14:57,360,760...57,370,764
Ensembl chr14:57,360,760...57,371,068

G

gap junction protein, delta 3

protein:decreased expression:retina

RGD

NCBI chr11:98,870,773...98,873,846
Ensembl chr11:98,873,006...98,873,842

G

glucagon-like peptide 1 receptor

RGD

NCBI chr17:31,120,841...31,155,484
Ensembl chr17:31,120,791...31,159,765

G

glutaredoxin

protein:increase activity:retina:

RGD

NCBI chr13:75,988,004...75,998,270
Ensembl chr13:75,987,987...75,998,273

G

glutamate-ammonia ligase

treatment

mRNA, protein:decreased expression: retina
protein:decreased expression:retina

RGD

PMID:21770802 PMID:23595285 PMID:25335981 PMID:23284834 PMID:26677078

RGD:401794412, RGD:401794586, RGD:401794423, RGD:401794421, RGD:401794418

NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469

G

guanine monophosphate synthetase

protein:increased activity:liver (rat)

RGD

NCBI chr 3:63,871,054...63,928,975
Ensembl chr 3:63,883,527...63,930,000

G

G protein subunit alpha transducin 1

protein:decreased expression:retina

RGD

NCBI chr 9:107,551,636...107,556,833
Ensembl chr 9:107,551,673...107,556,911

G

G protein subunit alpha transducin 3

mRNA, protein;increased expression:taste bud

RGD

NCBI chr 5:18,167,568...18,224,666
Ensembl chr 5:18,167,547...18,224,832

G

glycerol-3-phosphate acyltransferase, mitochondrial

CTD Direct Evidence: marker/mechanism

NCBI chr19:55,056,067...55,115,666
Ensembl chr19:55,055,700...55,115,670

G

glycerol phosphate dehydrogenase 2, mitochondrial

CTD Direct Evidence: marker/mechanism

NCBI chr 2:57,127,690...57,260,731
Ensembl chr 2:57,127,647...57,260,731

G

glutathione peroxidase 1

treatment

protein:increased expression:liver
CTD Direct Evidence: marker/mechanism
protein:increased expression:glomerulus

CTD
RGD

PMID:16123366 PMID:19229592 PMID:25744399 PMID:15039483 PMID:18387670

RGD:2306606, RGD:11353782, RGD:2306161, RGD:2306607

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

glutathione peroxidase 3

treatment

protein, mRNA:decreased expression:kidney (rat)

RGD

PMID:16651743 PMID:32546886 PMID:23407453 PMID:12753302

RGD:2312631, RGD:401827917, RGD:401827857, RGD:2312629

NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203

G

glutamate receptor, ionotropic, NMDA1 (zeta 1)

treatment

RGD

NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199

G

glutamate receptor, ionotropic, NMDA2B (epsilon 2)

mRNA, protein:increased expression:cerebellum (rat)

RGD

NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509

G

G protein-coupled receptor kinase 1

protein:increased expression:retina

RGD

NCBI chr 8:13,455,081...13,471,951
Ensembl chr 8:13,455,081...13,471,951

G

glycogen synthase kinase 3 alpha

treatment

RGD

NCBI chr 7:24,927,683...24,937,276
Ensembl chr 7:24,927,683...24,937,276

G

glutathione reductase

treatment

protein:decreased activity:plasma:
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20620209 PMID:20187988 PMID:25050809

RGD:7257587, RGD:10401889

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione S-transferase, alpha 4

protein:increased expression:pancreas, kidney, liver (rat)

RGD

NCBI chr 9:78,099,248...78,116,631
Ensembl chr 9:78,090,056...78,116,631

G

guanylate kinase 1

protein:decreased expression:retina (rat)

RGD

NCBI chr11:59,074,696...59,083,068
Ensembl chr11:59,074,701...59,083,069

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

RGD

NCBI chr 4:150,063,931...150,093,480
Ensembl chr 4:150,063,932...150,093,480

G

hydroxyacyl-Coenzyme A dehydrogenase

RGD

NCBI chr 3:131,027,068...131,065,750
Ensembl chr 3:131,027,068...131,065,750

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

protein:decreased expression:brain

RGD

NCBI chr 5:30,324,421...30,359,978
Ensembl chr 5:30,323,302...30,360,160

G

hyperpolarization activated cyclic nucleotide gated potassium channel 1

protein:increased expression:neuron:

RGD

NCBI chr13:117,738,856...118,117,564
Ensembl chr13:117,738,856...118,123,954

G

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

protein:increased expression:neuron:

RGD

NCBI chr10:79,552,468...79,571,942
Ensembl chr10:79,552,468...79,571,942

G

hyperpolarization-activated, cyclic nucleotide-gated K+ 3

protein:increased expression:neuron:

RGD

NCBI chr 3:89,054,082...89,067,538
Ensembl chr 3:89,053,381...89,067,503

G

histone deacetylase 1

protein:increased activity:renal cortex:

RGD

NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506

G

histone deacetylase 2

protein:increased activity:renal cortex:

RGD

NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885

G

histone deacetylase 4

protein:increased activity:renal cortex:

RGD

NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421

G

hepatocyte growth factor

protein:increased expression:kidney

RGD

NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150

G

hypoxia inducible factor 1, alpha subunit

protein:increased expression:sciatic nerve (rat)

RGD

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

hexokinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:62,104,634...62,215,699
Ensembl chr10:62,104,634...62,215,687

G

hydroxymethylbilane synthase

protein:decreased activity:liver (rat)

RGD

NCBI chr 9:44,247,645...44,255,525
Ensembl chr 9:44,247,636...44,255,525

G

high mobility group box 1

associated with Endotoxemia;protein:increased expression:serum
protein:increased expression, altered localization:retina, cytoplasm

RGD

PMID:19959191 PMID:23261684

RGD:2316737, RGD:10402069

NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299

G

3-hydroxy-3-methylglutaryl-Coenzyme A lyase

protein:increased activity:liver (rat)

RGD

NCBI chr 4:135,673,776...135,689,926
Ensembl chr 4:135,673,759...135,689,928

G

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

RGD

NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444

G

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

protein:increased expression:pancreas

RGD

NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796

G

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2

protein:increased expression:liver (rat)

RGD

NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054

G

heme oxygenase 1

CTD Direct Evidence: marker/mechanism|therapeutic

CTD
RGD

PMID:16123366 PMID:16959961 PMID:18375438 PMID:19804535 PMID:15734859

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

hepatic nuclear factor 4, alpha

mRNA:decreased expression:kidney, liver
protein:increased expression:liver:

RGD

PMID:18184923 PMID:19179483

RGD:2301838, RGD:12904769

NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830

G

heterogeneous nuclear ribonucleoprotein A2/B1

protein:increased expression:urinary bladder (rat)

RGD

NCBI chr 6:51,437,414...51,448,054
Ensembl chr 6:51,437,912...51,446,874

G

heterogeneous nuclear ribonucleoprotein K

treatment

RGD

NCBI chr13:58,538,946...58,551,157
Ensembl chr13:58,538,956...58,551,157

G

haptoglobin

protein:increased expression:serum

RGD

NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804

G

hypoxanthine phosphoribosyltransferase 1

protein:decreased activity:liver (rat)

RGD

NCBI chr X:52,076,955...52,110,537
Ensembl chr X:52,077,014...52,110,536

G

Harvey rat sarcoma virus oncogene

mRNA, protein:increased expression:retina blood vessel

RGD

NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918

G

hydroxysteroid 11-beta dehydrogenase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:192,903,917...192,946,345
Ensembl chr 1:192,903,942...192,946,383

G

heat shock protein 90, alpha (cytosolic), class A member 1

mRNA:decreased expression:brain (rat)

RGD

NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162

G

heat shock protein 1 (chaperonin)

RGD

NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402

G

perlecan (heparan sulfate proteoglycan 2)

mRNA:decreased expression:retina

RGD

NCBI chr 4:137,196,062...137,297,941
Ensembl chr 4:137,196,080...137,297,941

G

5-hydroxytryptamine (serotonin) receptor 2A

protein:increased expression:lung

RGD

NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934

G

islet amyloid polypeptide

CTD Direct Evidence: marker/mechanism

NCBI chr 6:142,244,151...142,249,546
Ensembl chr 6:142,244,149...142,249,687

G

intercellular adhesion molecule 1

treatment

protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:aorta

CTD
RGD

PMID:14871415 PMID:20388520 PMID:24513509 PMID:18413153 PMID:20136425 More...

RGD:2306987, RGD:8547703, RGD:2306988

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

inhibitor of DNA binding 1, HLH protein

CTD Direct Evidence: marker/mechanism

NCBI chr 2:152,578,171...152,579,330
Ensembl chr 2:152,578,171...152,579,330

G

insulin degrading enzyme

protein:decreased expression:cerebral cortex

RGD

NCBI chr19:37,246,140...37,341,664
Ensembl chr19:37,246,142...37,340,010

G

interferon (alpha and beta) receptor 1

RGD

NCBI chr16:91,281,016...91,307,411
Ensembl chr16:91,282,126...91,304,329

G

interferon gamma

mRNA:increased expression:pancreas
CTD Direct Evidence: marker/mechanism
protein:increased expression:retina

CTD
RGD

PMID:21340626 PMID:18789669 PMID:20213480

RGD:2311492, RGD:5147915

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

insulin-like growth factor 1

protein:decreased expression:cerebellum, serum
mRNA:altered expression:kidney
CTD Direct Evidence: therapeutic
mRNA,protein:decreased expression:corpus cavernosum:
protein:decreased expression:oviduct
protein:decreased expression:heart

CTD
RGD

PMID:24632065 PMID:19382144 PMID:7536658 PMID:22133301 PMID:18676006 More...

RGD:2306671, RGD:152176653, RGD:10046054, RGD:2311502, RGD:4142788

NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904

G

insulin-like growth factor I receptor

protein:decreased phosphorylation:heart
protein:decreased expression:oviduct

RGD

PMID:20555424 PMID:18676006

RGD:4142788, RGD:2311502

NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416

G

insulin-like growth factor 2

treatment

protein:increased expression:oviduct
mRNA:decreased expression:brain
DNA, mRNA:hypermethylation, decreased expression
protein:increased expression:multiple

RGD

PMID:18676006 PMID:23364485 PMID:10686593 PMID:18724775 PMID:17184497

RGD:2311502, RGD:10402565, RGD:5509973, RGD:2311511, RGD:2311513

NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553

G

insulin-like growth factor 2 receptor

protein:increased expression:oviduct

RGD

NCBI chr17:12,901,293...12,988,593
Ensembl chr17:12,901,293...12,988,551

G

insulin-like growth factor binding protein 1

mRNA:altered expression:kidney

RGD

NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546

G

insulin-like growth factor binding protein 2

mRNA:altered expression:kidney

RGD

NCBI chr 1:72,863,650...72,891,633
Ensembl chr 1:72,863,662...72,891,633

G

insulin-like growth factor binding protein 3

treatment

protein:increased expression:skeletal muscle
mRNA:altered expression:kidney
mRNA, protein:increased expression:penis

RGD

PMID:16180585 PMID:7536658 PMID:25582342 PMID:18068478

RGD:2313766, RGD:152176653, RGD:12743617, RGD:2289159

NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923

G

insulin-like growth factor binding protein 4

mRNA:altered expression:kidney

RGD

NCBI chr11:98,930,820...98,943,481
Ensembl chr11:98,932,070...98,945,218

G

insulin-like growth factor binding protein 5

mRNA:altered expression:kidney

RGD

NCBI chr 1:72,897,224...72,914,024
Ensembl chr 1:72,897,091...72,914,043

G

inhibitor of kappaB kinase beta

protein:increased phosphorylation:liver

RGD

NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605

G

interleukin 10

protein:increase expression:serum

RGD

PMID:18787467 PMID:18779928

RGD:2308945, RGD:2308946

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 17A

protein:increased expression:gingiva (rat)

RGD

NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720

G

interleukin 1 alpha

protein:increased expression:heart

RGD

NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892

G

interleukin 1 beta

mRNA:increased expression:skeletal muscle
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12123627 PMID:17669395 PMID:23197974

RGD:1626620, RGD:7175529

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 1 receptor antagonist

human gene in a rat model

RGD

PMID:19545727 PMID:17221214 PMID:8037760

RGD:6907397, RGD:8551855, RGD:6907425

NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506

G

interleukin 2

protein:increased expression:retina

RGD

NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108

G

interleukin 2 receptor, alpha chain

NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004

G

interleukin 4

treatment

RGD

NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496

G

interleukin 4 receptor, alpha

RGD

NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646

G

interleukin 6

protein:increased expression:heart
CTD Direct Evidence: marker/mechanism
protein:increased expression:blood
protein:increased expression:extracellular space (rat)

CTD
RGD

PMID:22138235 PMID:20555424 PMID:24582317 PMID:18976114 PMID:19328014

RGD:4142788, RGD:11049554, RGD:2306984, RGD:2307252

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

insulin I

CTD Direct Evidence: therapeutic

PMID:2975197 PMID:3044883

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

G

insulin induced gene 1

RGD

NCBI chr 5:28,276,410...28,283,660
Ensembl chr 5:28,276,361...28,283,660

G

insulin receptor

disease_progression
treatment

protein:decreased expression:kidney
mRNA:increased expression:liver nuclei, liver cell membrane (rat)
associated with streptozocin;protein:altered activity:liver plasma membrane (rat)
CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:liver, adipose tissue (rat)
protein:decreased expression:erythrocyte (rat)
protein:increased expression:gastrocnemius (rat)

CTD
RGD

PMID:9243097 PMID:22138235 PMID:17855644 PMID:1280238 PMID:2180315 More...

RGD:2290475, RGD:15036814, RGD:14981592, RGD:10403045, RGD:2307025, RGD:2307339, RGD:2307338

NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617

G

insulin receptor substrate 1

treatment

CTD Direct Evidence: marker/mechanism
mRNA, protein:decreased expression:multiple

CTD
RGD

PMID:22138235 PMID:22983684 PMID:22820932

RGD:7207061, RGD:7207063

NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137

G

insulin receptor substrate 2

protein:decreased phosphorylation:heart
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:25808216 PMID:20555424

NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458

G

ISG15 ubiquitin-like modifier

RGD

NCBI chr 4:156,283,881...156,285,275
Ensembl chr 4:156,283,912...156,285,253

G

integrin alpha 3

protein:decreased expression:renal cortex (rat)

RGD

NCBI chr11:94,935,301...94,967,637
Ensembl chr11:94,935,300...94,967,627

G

integrin alpha M

protein:increased expression:neutrophil (rat)

RGD

NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663

G

integrin beta 1 (fibronectin receptor beta)

protein:decreased expression:epidermal stem cell (rat)

RGD

NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681

G

integrin beta 3

protein:increased expression:aorta:

RGD

NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302

G

Janus kinase 3

protein:increased expression:retina

RGD

NCBI chr 8:72,129,027...72,143,221
Ensembl chr 8:72,128,940...72,143,219

G

potassium voltage-gated channel, shaker-related subfamily, member 2

RGD

NCBI chr 3:106,998,203...107,022,321
Ensembl chr 3:107,008,462...107,022,321

G

potassium voltage-gated channel, shaker-related subfamily, member 5

RGD

NCBI chr 6:126,509,514...126,512,518
Ensembl chr 6:126,509,514...126,512,375

G

potassium voltage-gated channel, Isk-related subfamily, gene 2

mRNA:decreased expression:left heart ventricle

RGD

NCBI chr16:92,089,277...92,095,021
Ensembl chr16:92,089,277...92,095,017

G

potassium inwardly rectifying channel, subfamily J, member 11

protein:decreased expression:brain
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16123366 PMID:23785408

NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188

G

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

mRNA, protein:decreased expression:aorta, smooth muscle

RGD

NCBI chr14:23,342,356...24,055,173
Ensembl chr14:23,339,499...24,064,559

G

potassium large conductance calcium-activated channel, subfamily M, beta member 1

protein:decreased expression:aorta, smooth muscle

RGD

NCBI chr11:33,912,955...33,923,641
Ensembl chr11:33,913,013...33,923,641

G

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

ameliorates

mRNA, protein:increased expression:aorta, smooth muscle

RGD

PMID:24589593 PMID:29167619

RGD:10412030, RGD:401784495

NCBI chr 7:24,069,750...24,084,635
Ensembl chr 7:24,069,688...24,086,115

G

lysine (K)-specific demethylase 6A

RGD

NCBI chr X:18,027,101...18,147,061
Ensembl chr X:18,028,814...18,146,175

G

kinase insert domain protein receptor

mRNA:decreased expression:skeletal muscle
mRNA:increased expression:retina
mRNA:decreased expression:heart

RGD

PMID:16816123 PMID:22121831 PMID:16741021

RGD:2313725, RGD:5684538, RGD:2313724

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

ketohexokinase

RGD

NCBI chr 5:31,078,780...31,088,592
Ensembl chr 5:31,078,775...31,088,592

G

kinesin family member 1A

mRNA:increased expression:hippocampus

RGD

NCBI chr 1:92,943,180...93,029,760
Ensembl chr 1:92,943,186...93,029,673

G

kinesin family member 5B

mRNA:increased expression:hippocampus

RGD

NCBI chr18:6,201,005...6,241,524
Ensembl chr18:6,201,002...6,242,174

G

KIT proto-oncogene receptor tyrosine kinase

protein:increased expression:pancreas

RGD

NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382

G

kallikrein 1

mRNA:decreased expression:myocardium

RGD

NCBI chr 7:43,874,784...43,879,046
Ensembl chr 7:43,874,784...43,879,042

G

lysine methyltransferase 5C

mRNA:increased expression:retina

RGD

NCBI chr 7:4,743,091...4,750,513
Ensembl chr 7:4,743,114...4,750,513

G

lipocalin 2

mRNA:increased expression:retina (rat)
protein:increased expression:urine

RGD

PMID:15623795 PMID:23085980

RGD:2316515, RGD:7245484

NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264

G

lactase

RGD

NCBI chr 1:128,212,493...128,256,055
Ensembl chr 1:128,212,493...128,256,055

G

low density lipoprotein receptor

mRNA:decreased expression:liver

RGD

NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215

G

leptin

onset

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:28242381 PMID:31313498 PMID:31483951 PMID:19491210 PMID:19428774 More...

RGD:2311124, RGD:2311126, RGD:5128579

NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876

G

leptin receptor

CTD Direct Evidence: marker/mechanism

PMID:15093691 PMID:16427799 PMID:17065336 PMID:19452630 PMID:19478208 More...

NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549

G

lectin, galactose binding, soluble 3

treatment

RGD

NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617

G

lipase, hepatic

protein:decreased activity:liver (rat)

RGD

PMID:18758746 PMID:1868959

RGD:2307432, RGD:2308849

NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508

G

LPS-induced TN factor

protein:increased expression:retina

RGD

NCBI chr16:10,777,137...10,810,985
Ensembl chr16:10,777,139...10,884,021

G

lipin 1

mRNA:increased expression:skeletal muscle

RGD

NCBI chr12:16,585,670...16,697,020
Ensembl chr12:16,585,670...16,696,967

G

lipoprotein lipase

treatment

RGD

PMID:18780778 PMID:27158912

RGD:2313303, RGD:13794379

NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100

G

low density lipoprotein receptor-related protein 2

protein:decreased expression:kidney, proximal convoluted tubule, apical plasma membrane

RGD

NCBI chr 2:69,254,679...69,416,373
Ensembl chr 2:69,254,684...69,416,409

G

latent transforming growth factor beta binding protein 1

RGD

NCBI chr17:75,312,475...75,699,507
Ensembl chr17:75,312,563...75,699,507

G

MAF bZIP transcription factor A

treatment

RGD

NCBI chr15:75,617,350...75,620,170
Ensembl chr15:75,617,339...75,620,077

G

mitogen-activated protein kinase kinase 3

mRNA:increased expression:kidney, glomerulus

RGD

NCBI chr11:60,822,880...60,843,637
Ensembl chr11:60,822,859...60,843,637

G

mitogen-activated protein kinase kinase 6

mRNA:increased expression:kidney, glomerulus

RGD

NCBI chr11:110,289,928...110,416,348
Ensembl chr11:110,289,948...110,416,348

G

mitogen-activated protein kinase kinase kinase 5

CTD Direct Evidence: marker/mechanism

NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499

G

mitogen-activated protein kinase kinase kinase 8

protein:increased activity:serum:

RGD

NCBI chr18:4,331,325...4,352,978
Ensembl chr18:4,331,327...4,353,015

G

mitogen-activated protein kinase 1

protein:decreased phosphorylation:cornea

RGD

PMID:22045654 PMID:21330660

RGD:7243969, RGD:5131482

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

protein:decreased phosphorylation:cornea

RGD

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

microtubule-associated protein tau

treatment

RGD

NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916

G

MAS1 oncogene

mRNA:increased expression:renal cortex (rat)

RGD

NCBI chr17:13,056,981...13,087,037
Ensembl chr17:13,059,966...13,087,030

G

myelin basic protein

RGD

NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762

G

transformed mouse 3T3 cell double minute 2

protein:increased degradation:myocardium

RGD

NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663

G

myocyte enhancer factor 2A

mRNA:increased expression:heart

RGD

NCBI chr 7:66,880,911...67,026,435
Ensembl chr 7:66,880,911...67,022,606

G

myocyte enhancer factor 2C

mRNA:increased expression:heart

RGD

NCBI chr13:83,652,136...83,815,197
Ensembl chr13:83,652,153...83,815,199

G

met proto-oncogene

mRNA, protein:increased expression:kidney, tubule, epithelium (rat)

RGD

NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979

G

milk fat globule EGF and factor V/VIII domain containing

CTD Direct Evidence: marker/mechanism

NCBI chr 7:78,783,516...78,798,808
Ensembl chr 7:78,783,516...78,798,808

G

mitofusin 2

treatment

protein:increased expression:heart, mitochondrion (rat)

RGD

PMID:28483572 PMID:27998959

RGD:12910731, RGD:12910739

NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161

G

macrophage migration inhibitory factor (glycosylation-inhibiting factor)

protein:increased expression:pancreatic islet

RGD

NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074

G

matrix metallopeptidase 1a (interstitial collagenase)

protein:increased expression:periodontal ligament, alveolar bone of mandible (rat)

RGD

NCBI chr 9:7,464,141...7,476,870
Ensembl chr 9:7,464,141...7,476,857

G

matrix metallopeptidase 1b (interstitial collagenase)

protein:increased expression:periodontal ligament, alveolar bone of mandible (rat)

NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047

G

matrix metallopeptidase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

treatment

protein:increased expression:kidney
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21963884 PMID:22191573 PMID:17569353 PMID:23089644 PMID:23423566

RGD:2290354, RGD:8547974, RGD:8547881

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

myeloperoxidase

protein:increased activity:liver:
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20388520 PMID:18436980

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

cytochrome c oxidase II, mitochondrial

CTD Direct Evidence: marker/mechanism

NCBI chr MT:7,013...7,696
Ensembl chr MT:7,013...7,696

G

cytochrome b, mitochondrial

mRNA:decreased expression:heart

RGD

NCBI chr MT:14,145...15,288
Ensembl chr MT:14,145...15,288

G

NADH dehydrogenase 1, mitochondrial

CTD Direct Evidence: marker/mechanism

NCBI chr MT:2,751...3,707
Ensembl chr MT:2,751...3,707

G

methylenetetrahydrofolate reductase

protein:decreased activity:kidney (rat)

RGD

NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008

G

mechanistic target of rapamycin kinase

protein:hyperphosphorylation:muscle

RGD

NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140

G

5-methyltetrahydrofolate-homocysteine methyltransferase

protein:decreased activity:liver

RGD

NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999

G

myelocytomatosis oncogene

mRNA:increased expression:renal cortex (rat)

RGD

NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223

G

nicotinamide phosphoribosyltransferase

protein:decreased expression:fat cell

RGD

NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348

G

neutrophil cytosolic factor 1

CTD Direct Evidence: marker/mechanism

PMID:14871415 PMID:16380483

NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479

G

neutrophil cytosolic factor 2

protein:increased expression:heart, membrane fraction
protein:altered localization:glomerulus

RGD

PMID:18061195 PMID:14514646

RGD:2314434, RGD:2314451

NCBI chr 1:152,675,904...152,712,743
Ensembl chr 1:152,675,945...152,712,742

G

NADH:ubiquinone oxidoreductase core subunit S2

protein:decreased expression:dorsal root ganglia (rat)

RGD

NCBI chr 1:171,062,426...171,078,956
Ensembl chr 1:171,062,422...171,078,957

G

NADH:ubiquinone oxidoreductase core subunit S3

protein:decreased expression:dorsal root ganglia (rat)
mRNA, protein:decreased expression:brain

RGD

PMID:20876714 PMID:22387129

RGD:6484699, RGD:13824971

NCBI chr 2:90,724,971...90,735,065
Ensembl chr 2:90,724,978...90,735,171

G

neurofilament, heavy polypeptide

treatment

RGD

NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064

G

neurofilament, medium polypeptide

treatment

RGD

NCBI chr14:68,356,994...68,362,453
Ensembl chr14:68,320,039...68,362,295

G

neurogenic differentiation 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:79,282,981...79,286,980
Ensembl chr 2:79,282,865...79,287,095

G

neurogenin 3

RGD

NCBI chr10:61,968,869...61,970,542
Ensembl chr10:61,968,869...61,970,542

G

nuclear factor, erythroid derived 2, like 2

treatment

protein:increased localization:blood, mononuclear cell, nucleus

RGD

PMID:22869588 PMID:23331247 PMID:24740568

RGD:10412694, RGD:7244270, RGD:10412720

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100

RGD

NCBI chr19:46,285,478...46,300,839
Ensembl chr19:46,292,759...46,300,824

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

treatment

protein:decreased expression:kidney

RGD

PMID:22483164 PMID:20188823

RGD:10413864, RGD:10413873

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nerve growth factor

treatment

mRNA, protein:decreased expression:sciatic nerve
protein:decreased processing:hippocampus
protein:increased expression:retina

RGD

PMID:19149268 PMID:25728260 PMID:26282349 PMID:21136036

RGD:2303795, RGD:402463972, RGD:402463971, RGD:5144144

NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329

G

nerve growth factor receptor (TNFR superfamily, member 16)

protein:increased expression:retina
protein:decreased expression:telencephalon

RGD

PMID:21136036 PMID:26282349

RGD:5144144, RGD:402463971

NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561

G

NK6 homeobox 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:101,807,050...101,812,577
Ensembl chr 5:101,806,005...101,812,862

G

nitric oxide synthase 1, neuronal

protein:decreased dimerization:stomach

RGD

NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905

G

nitric oxide synthase 2, inducible

no_association

associated with Infarction, Middle Cerebral Artery; protein:increased expression:brain (rat)
CTD Direct Evidence: marker/mechanism
protein:increased expression:renal glomerulus (rat)

CTD
RGD

PMID:16380483 PMID:16959961 PMID:21993016 PMID:9349594

RGD:5509105, RGD:5509107

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

treatment

protein:increased expression:heart
CTD Direct Evidence: marker/mechanism
protein:decreased expression:thoracic aorta (mouse)

CTD
RGD

PMID:11696579 PMID:14871415 PMID:15490108 PMID:16959961 PMID:18266981 More...

RGD:2292100, RGD:13450939, RGD:7777108, RGD:7777108, RGD:4892007

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

NADPH oxidase 4

protein:increased expression:aorta

RGD

NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918

G

NPC1 like intracellular cholesterol transporter 1

mRNA:increased expression:intestine, liver

RGD

NCBI chr11:6,161,011...6,180,245
Ensembl chr11:6,161,013...6,180,143

G

natriuretic peptide type A

protein:decreased expression:retina
protein:increased expression:plasma, kidney, heart;

RGD

PMID:15789000 PMID:17151304

RGD:1580773, RGD:7248602

NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536

G

natriuretic peptide type B

protein:increased expression:atrium myocardium, plasma

RGD

NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662

G

neuropeptide Y

protein:increased expression:paraventricular nucleus of hypothalamus

RGD

NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487

G

neuropeptide Y receptor Y1

RGD

NCBI chr 8:67,149,595...67,159,452
Ensembl chr 8:67,149,844...67,159,444

G

neuropeptide Y receptor Y2

RGD

NCBI chr 3:82,445,688...82,455,404
Ensembl chr 3:82,445,690...82,455,391

G

NAD(P)H dehydrogenase, quinone 1

CTD Direct Evidence: therapeutic

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

nuclear receptor subfamily 1, group H, member 3

DNA, mRNA, protein:hypomethylation, increased expression:promoter, heart

RGD

NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179

G

nuclear receptor subfamily 1, group H, member 4

mRNA:decreased expression:liver

RGD

NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447

G

nuclear receptor subfamily 1, group I, member 3

treatment

RGD

NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270

G

nuclear receptor subfamily 3, group C, member 1

treatment

protein:increased expression:placenta

RGD

PMID:21744335 PMID:26883980

RGD:12879479, RGD:14695543

NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474

G

neuropilin 1

mRNA:decreased expression:skeletal muscle

RGD

NCBI chr 8:129,085,553...129,231,957
Ensembl chr 8:129,085,085...129,229,844

G

5' nucleotidase, ecto

protein:increased expression:cerebral cortex, synaptosome (rat)

RGD

NCBI chr 9:88,209,662...88,254,142
Ensembl chr 9:88,209,250...88,254,145

G

neurotrophic tyrosine kinase, receptor, type 1

protein:increased tyrosine nitration, decreased tyrosine phosphorylation:retina

RGD

PMID:21136036 PMID:22044876

RGD:5144144, RGD:5684337

NCBI chr 3:87,685,551...87,702,549
Ensembl chr 3:87,685,551...87,702,469

G

neurotrophic tyrosine kinase, receptor, type 2

treatment

RGD

NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784

G

neurotrophic tyrosine kinase, receptor, type 3

mRNA:decreased expression:dorsal root ganglion

RGD

NCBI chr 7:77,825,711...78,228,865
Ensembl chr 7:77,825,707...78,387,760

G

8-oxoguanine DNA-glycosylase 1

protein:altered localization:pancreatic islet

RGD

PMID:18676009 PMID:18599524 PMID:15677345

RGD:2317137, RGD:8657153, RGD:8657146

NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029

G

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

treatment

RGD

NCBI chr X:100,683,617...100,727,957
Ensembl chr X:100,683,666...100,727,957

G

opioid receptor, kappa 1

protein:increased expression:sciatic nerve, peroneal nerve:

RGD

NCBI chr 1:5,658,673...5,676,357
Ensembl chr 1:5,658,689...5,676,354

G

opioid receptor, mu 1

RGD

NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198

G

oxysterol binding protein

protein:increased tyrosine phosphorylation:aorta

RGD

NCBI chr19:11,943,208...11,971,478
Ensembl chr19:11,943,305...11,971,476

G

ornithine transcarbamylase

protein:decreased activity:small intestine (rat)

RGD

NCBI chr X:10,118,584...10,187,275
Ensembl chr X:10,118,544...10,187,263

G

3-oxoacid CoA transferase 1

protein:decreased activity:heart, mitochondrion (rat)

RGD

NCBI chr15:4,055,910...4,184,826
Ensembl chr15:4,055,865...4,184,826

G

poly (ADP-ribose) polymerase family, member 1

RGD

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

paired box 6

CTD Direct Evidence: marker/mechanism

NCBI chr 2:105,499,241...105,528,755
Ensembl chr 2:105,499,245...105,527,709

G

phosphoenolpyruvate carboxykinase 1, cytosolic

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20363216 PMID:17651728

NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066

G

proprotein convertase subtilisin/kexin type 1

mRNA, protein:increased expression:spleen (mouse)
mRNA, protein:increased expression:spleen, spleen white pulp (rat)
protein:increased expression:pancreatic alpha cell (mouse)

RGD

PMID:11730986 PMID:11730986 PMID:17698597

RGD:2308905, RGD:2308905, RGD:2308931

NCBI chr13:75,237,407...75,282,980
Ensembl chr13:75,237,945...75,282,980

G

proprotein convertase subtilisin/kexin type 2

mRNA:increased expression:spleen
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16123366 PMID:11730986

NCBI chr 2:143,388,053...143,658,204
Ensembl chr 2:143,388,076...143,658,205

G

pyruvate carboxylase

CTD Direct Evidence: marker/mechanism

NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780

G

phosphodiesterase 3A, cGMP inhibited

mRNA, protein:increased expression:mesenteric artery

RGD

NCBI chr 6:141,194,995...141,452,588
Ensembl chr 6:141,194,995...141,453,174

G

phosphodiesterase 5A, cGMP-specific

RGD

NCBI chr 3:122,522,822...122,653,023
Ensembl chr 3:122,522,596...122,653,023

G

platelet derived growth factor, B polypeptide

mRNA:increased expression:retina
mRNA: increased expression: mesenteric artery
mRNA:increased expression:glomerulus
mRNA:decreased expression:retina

RGD

PMID:12606528 PMID:9763208 PMID:21367419 PMID:8094359 PMID:14685146

RGD:1581759, RGD:10449499, RGD:6483042, RGD:2311650, RGD:2311648

NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178

G

platelet derived growth factor receptor, beta polypeptide

protein:increased expression:glomerulus

RGD

NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133

G

pyruvate dehydrogenase kinase, isoenzyme 4

CTD Direct Evidence: marker/mechanism

NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309

G

pyruvate dehydrogenase phosphatase catalytic subunit 2

RGD

NCBI chr 8:105,318,104...105,325,658
Ensembl chr 8:105,318,083...105,325,658

G

pancreatic and duodenal homeobox 1

CTD Direct Evidence: marker/mechanism
protein:increased expression:pancreatic delta cell (rat)
protein:increased expression:pancreas (rat)

CTD
RGD

PMID:16123366 PMID:17460716 PMID:14988244 PMID:15561947 PMID:17235568 More...

RGD:2311224, RGD:1357906, RGD:2311226, RGD:2311225, RGD:2311311

NCBI chr 5:147,206,907...147,212,658
Ensembl chr 5:147,206,769...147,212,658

G

prodynorphin

protein:increased expression:sciatic nerve, peroneal nerve, tibial nerve, footpad skin:

RGD

NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764

G

platelet/endothelial cell adhesion molecule 1

protein:decreased expression:corpus callosum, endothelium (rat)

RGD

NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454

G

phosphatidylethanolamine N-methyltransferase

protein:increased expression:liver

RGD

NCBI chr11:59,861,440...59,937,394
Ensembl chr11:59,861,440...59,937,315

G

phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)

protein:increased activity:liver (rat)

RGD

NCBI chr11:68,876,527...68,899,286
Ensembl chr11:68,876,523...68,899,286

G

phosphofructokinase, muscle

CTD Direct Evidence: marker/mechanism

NCBI chr15:97,990,470...98,030,328
Ensembl chr15:97,990,470...98,030,332

G

placental growth factor

mRNA, protein:decreased expression:placenta, trophoblast cell

RGD

NCBI chr12:85,213,413...85,224,087
Ensembl chr12:85,213,409...85,224,564

G

phosphorylase kinase alpha 1

RGD

NCBI chr X:101,557,581...101,687,907
Ensembl chr X:101,557,581...101,687,852

G

phosphoinositide-3-kinase regulatory subunit 1

protein:increased expression:gastrocnemius (rat)

RGD

NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725

G

pyruvate kinase liver and red blood cell

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20363216 PMID:16900249

NCBI chr 3:89,043,429...89,054,122
Ensembl chr 3:89,043,449...89,054,091

G

phospholipase C, beta 3

protein:decreased expression:heart left ventricle

RGD

NCBI chr19:6,931,081...6,951,738
Ensembl chr19:6,929,693...6,953,838

G

phospholipase C, gamma 1

protein:increased tyrosine phosphorylation:lens

RGD

NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680

G

phenylethanolamine-N-methyltransferase

protein:increased expression:adrenal gland (rat)

RGD

NCBI chr11:98,277,449...98,279,006
Ensembl chr11:98,277,276...98,279,007

G

polymerase (DNA directed), gamma

mRNA,protein:decreased expression:retina,mitochondrion:

RGD

PMID:22743328 PMID:22229649

RGD:8694093, RGD:8694187

NCBI chr 7:79,095,979...79,117,659
Ensembl chr 7:79,095,979...79,116,110

G

polymerase (DNA directed), gamma 2, accessory subunit

mRNA,protein:decreased expression:retina,mitochondrion:

RGD

NCBI chr11:106,659,030...106,670,363
Ensembl chr11:106,659,079...106,670,363

G

paraoxonase 1

RGD

PMID:18358245 PMID:18358245

RGD:2313268, RGD:2313268

NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946

G

peroxisome proliferator activated receptor alpha

CTD Direct Evidence: marker/mechanism

PMID:12967931 PMID:14563825 PMID:23090186

NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020

G

peroxisome proliferator activator receptor delta

mRNA, protein:decreased expression:heart

RGD

NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448

G

peroxisome proliferator activated receptor gamma

mRNA:altered expression:aorta, kidney cortex, retina
CTD Direct Evidence: marker/mechanism
protein:decreased expression:retina

CTD
RGD

PMID:12967931 PMID:16123366 PMID:21757225 PMID:18641696 PMID:18806296

RGD:2301849, RGD:2301844

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

treatment

mRNA:decreased expression:pancreatic islet
CTD Direct Evidence: marker/mechanism
protein:decreased expression:dorsal root ganglia (mouse)

CTD
RGD

PMID:14563825 PMID:18270681 PMID:19520786 PMID:22561641 PMID:23272147

RGD:2311391, RGD:2311445, RGD:7242175, RGD:7241845

NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068

G

phosphoribosyl pyrophosphate amidotransferase

protein:increased activity:kidney (rat)

RGD

NCBI chr 5:77,061,096...77,099,425
Ensembl chr 5:77,061,096...77,099,425

G

protein kinase, AMP-activated, alpha 2 catalytic subunit

treatment

RGD

NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087

G

protein kinase C, alpha

CTD Direct Evidence: marker/mechanism

NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754

G

protein kinase C, beta

protein:increased expression:myocardium

RGD

NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625

G

protein kinase C, delta

protein:increased expression:kidney
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12198386 PMID:11576956

NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167

G

protein kinase C, epsilon

CTD Direct Evidence: marker/mechanism

NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347

G

protein kinase C, iota

protein:increased expression:ventricle myocardium, membrane fraction

RGD

NCBI chr 3:31,049,893...31,106,889
Ensembl chr 3:31,049,896...31,107,108

G

protein kinase, cGMP-dependent, type I

treatment

protein:decreased expression:aorta

RGD

PMID:20186099 PMID:15939056

RGD:7775064, RGD:7777110

NCBI chr19:30,541,887...31,742,675
Ensembl chr19:30,541,889...31,742,433

G

protein kinase, interferon inducible double stranded RNA dependent activator

RGD

NCBI chr 2:76,436,385...76,478,614
Ensembl chr 2:76,460,242...76,478,359

G

proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)

mRNA:increased expression:hippocampus (rat)

RGD

NCBI chr17:34,401,006...34,406,347
Ensembl chr17:34,400,961...34,406,738

G

prostaglandin I2 (prostacyclin) synthase

treatment

RGD

NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524

G

prostaglandin-endoperoxide synthase 1

protein:decreased expression:spinal cord

RGD

NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284

G

prostaglandin-endoperoxide synthase 2

CTD Direct Evidence: marker/mechanism
protein:increased expression:lung
protein:increased expression:sciatic nerve

CTD
RGD

PMID:14514642 PMID:21414306 PMID:18706904 PMID:21521772 PMID:17720896

RGD:2300222, RGD:5135278, RGD:1642588

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

protein tyrosine phosphatase, non-receptor type 1

protein:increased activity:retina (mouse)

RGD

NCBI chr 2:167,772,670...167,821,305
Ensembl chr 2:167,773,977...167,821,305

G

protein tyrosine phosphatase receptor type N

severity

RGD

NCBI chr 1:75,223,679...75,241,437
Ensembl chr 1:75,223,671...75,241,146

G

protein tyrosine phosphatase receptor type U

protein:decreased expression:glomerulus

RGD

NCBI chr 4:131,495,768...131,565,617
Ensembl chr 4:131,495,768...131,565,599

G

muscle glycogen phosphorylase

protein:increased expression:sarcoplasmic reticulum

RGD

NCBI chr19:6,434,438...6,448,494
Ensembl chr19:6,434,429...6,448,489

G

quinoid dihydropteridine reductase

protein:decreased activity:brain (rat)

RGD

NCBI chr 5:45,591,374...45,607,571
Ensembl chr 5:45,591,363...45,607,578

G

receptor (calcitonin) activity modifying protein 2

mRNA:increased expression:kidney

RGD

NCBI chr11:101,137,160...101,139,076
Ensembl chr11:101,136,854...101,150,372

G

RAS related protein 1b

protein:increased expression:renal glomerulus (rat)

RGD

NCBI chr10:117,650,502...117,681,879
Ensembl chr10:117,649,776...117,681,940

G

RAS protein-specific guanine nucleotide-releasing factor 1

protein:decreased expression:brain, membrane (rat)

RGD

NCBI chr 9:89,791,565...89,909,032
Ensembl chr 9:89,791,961...89,909,030

G

RNA binding protein, fox-1 homolog (C. elegans) 2

mRNA:splice variant: heart (mouse)
protein:increased expression:heart, cytoplasm (mouse)

RGD

PMID:27239029 PMID:24151077

RGD:329845874, RGD:329848997

NCBI chr15:76,963,190...77,193,058
Ensembl chr15:76,963,190...77,191,204

G

regenerating islet-derived 1

treatment

protein:increased expression:pancreas, islet cell (rat)

RGD

PMID:8170952 PMID:8574288

RGD:9850123, RGD:9850143

NCBI chr 6:78,402,966...78,405,651
Ensembl chr 6:78,399,694...78,405,650

G

regenerating islet-derived 3 beta

susceptibility

RGD

NCBI chr 6:78,347,868...78,350,449
Ensembl chr 6:78,347,640...78,350,449

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

CTD Direct Evidence: marker/mechanism
protein:increased expression:nucleus, skeletal muscle, liver

CTD
RGD

PMID:22138235 PMID:18633731 PMID:18500427

RGD:2298775, RGD:2298780

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

renin 1 structural

CTD Direct Evidence: marker/mechanism

NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063

G

regucalcin

protein:decreased expression:liver

RGD

NCBI chr X:20,413,980...20,428,328
Ensembl chr X:20,416,026...20,428,328

G

ras homolog family member A

NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133

G

retinal pigment epithelium 65

mRNA:decreased expression:retina (rat)

RGD

NCBI chr 3:159,304,712...159,330,944
Ensembl chr 3:159,304,812...159,330,958

G

ryanodine receptor 2, cardiac

RGD

NCBI chr13:11,567,985...12,121,831
Ensembl chr13:11,567,988...12,121,831

G

S100 calcium binding protein A6 (calcyclin)

CTD Direct Evidence: marker/mechanism

NCBI chr 3:90,520,491...90,531,797
Ensembl chr 3:90,520,189...90,531,488

G

S100 protein, beta polypeptide, neural

protein:increased expression:cerebellum, cerebral cortex, hippocampus
protein:altered expression:hippocampus, astrocyte

RGD

PMID:14583344 PMID:18708122

RGD:5508821, RGD:5508836

NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993

G

sphingosine-1-phosphate receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:20,877,248...20,888,089
Ensembl chr 9:20,873,657...20,888,077

G

sphingosine-1-phosphate receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr10:81,333,579...81,335,971
Ensembl chr10:81,333,581...81,335,966

G

sphingosine-1-phosphate receptor 5

CTD Direct Evidence: marker/mechanism

NCBI chr 9:21,154,213...21,159,739
Ensembl chr 9:21,154,208...21,159,739

G

SREBF chaperone

RGD

NCBI chr 9:110,162,356...110,214,017
Ensembl chr 9:110,162,356...110,214,018

G

stearoyl-Coenzyme A desaturase 1

treatment

RGD

NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318

G

sterol carrier protein 2, liver

treatment

RGD

NCBI chr 4:107,901,027...108,002,168
Ensembl chr 4:107,901,036...108,002,195

G

selectin, platelet

treatment

RGD

NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595

G

serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1

treatment

RGD

PMID:22309505 PMID:24671746

RGD:11035271, RGD:11035293

NCBI chr 1:160,806,153...160,830,113
Ensembl chr 1:160,806,155...160,833,433

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

protein:increased expression:heart (mouse)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21757225 PMID:20630999

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

serine (or cysteine) peptidase inhibitor, clade F, member 1

protein:decreased expression:platelet

RGD

NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527

G

sirtuin 1

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:23090186 PMID:23792339 PMID:22179968

NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483

G

sucrase isomaltase

protein:increased expression:small intestine mucosa

RGD

NCBI chr 3:72,795,890...72,875,196
Ensembl chr 3:72,795,890...72,875,196

G

solute carrier family 1 (glial high affinity glutamate transporter), member 3

treatment

RGD

NCBI chr15:8,663,608...8,742,648
Ensembl chr15:8,663,608...8,740,248

G

solute carrier family 22 (organic cation transporter), member 1

NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716

G

solute carrier family 22 (organic cation transporter), member 2

protein:decreased expression:kidney

RGD

NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375

G

solute carrier family 28 (sodium-coupled nucleoside transporter), member 2

NCBI chr 2:122,256,836...122,291,633
Ensembl chr 2:122,256,958...122,291,618

G

solute carrier family 28 (sodium-coupled nucleoside transporter), member 3

NCBI chr13:58,701,121...58,758,691
Ensembl chr13:58,693,213...58,758,691

G

solute carrier family 29 (nucleoside transporters), member 1

mRNA:decreased expression:cardiac muscle cell

RGD

NCBI chr17:45,896,126...45,910,544
Ensembl chr17:45,896,126...45,910,532

G

solute carrier family 2 (facilitated glucose transporter), member 1

treatment

mRNA, protein:decreased expression:brain

RGD

PMID:17935675 PMID:8345816

RGD:2313617, RGD:12879858

NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180

G

solute carrier family 2 (facilitated glucose transporter), member 2

mRNA:increased expression:kidney
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16123366 PMID:19433262

NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508

G

solute carrier family 2 (facilitated glucose transporter), member 3

mRNA, protein:decreased expression:brain

RGD

NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599

G

solute carrier family 2 (facilitated glucose transporter), member 4

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:11947963 PMID:14563825 PMID:18266981 PMID:22138235 PMID:19252289

NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014

G

solute carrier family 37 (glucose-6-phosphate transporter), member 4

protein:increased expression:liver

RGD

NCBI chr 9:44,308,243...44,314,263
Ensembl chr 9:44,308,149...44,314,265

G

solute carrier family 38, member 2

RGD

NCBI chr15:96,585,267...96,597,609
Ensembl chr15:96,585,273...96,597,611

G

solute carrier family 8 (sodium/calcium exchanger), member 1

mRNA, protein:decreased expression:cardiac muscle cell

RGD

NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806

G

solute carrier family 9 (sodium/hydrogen exchanger), member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:133,097,022...133,151,013
Ensembl chr 4:133,097,017...133,151,013

G

solute carrier family 9 (sodium/hydrogen exchanger), member 3

protein:increased activity:kidney cortex
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20003708 PMID:16244498

NCBI chr13:74,234,374...74,317,561
Ensembl chr13:74,269,576...74,317,561

G

SMAD family member 1

severity

protein:increased expression:glomerulus, urine

RGD

NCBI chr 8:80,065,024...80,126,057
Ensembl chr 8:80,065,024...80,126,147

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

treatment

RGD

NCBI chr 9:21,527,377...21,615,526
Ensembl chr 9:21,527,465...21,615,526

G

sphingomyelin phosphodiesterase 1, acid lysosomal

protein:decreased expression:gastrocnemius

RGD

NCBI chr 7:105,203,567...105,207,596
Ensembl chr 7:105,203,567...105,207,596

G

synaptosomal-associated protein 25

CTD Direct Evidence: marker/mechanism

NCBI chr 2:136,555,359...136,624,348
Ensembl chr 2:136,555,373...136,624,348

G

sterol O-acyltransferase 2

RGD

NCBI chr15:102,058,853...102,071,871
Ensembl chr15:102,058,961...102,071,904

G

suppressor of cytokine signaling 3

susceptibility

mRNA, protein:increased expression:retina

PMID:18356406 PMID:17562326

RGD:2298911, RGD:2313787

NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873

G

superoxide dismutase 1, soluble

protein:increased expression:hippocampus (rat)
associated with alcohol use disorder; protein:decreased activity;testis, epididymis (rat)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:23090186 PMID:20924670 PMID:25541261

RGD:8655956, RGD:405255664

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

protein:increased activity:testes
CTD Direct Evidence: marker/mechanism|therapeutic

CTD
RGD

PMID:15855331 PMID:23090186 PMID:19891634

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

sorbitol dehydrogenase

protein:increased expression:liver

RGD

NCBI chr 2:122,065,320...122,095,818
Ensembl chr 2:122,065,230...122,095,821

G

SRY (sex determining region Y)-box 2

RGD

NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610

G

secreted phosphoprotein 1

RGD

NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916

G

sterol regulatory element binding transcription factor 1

treatment

mRNA, protein:increased expression:renal proximal tubule, epithelial cell
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:10900012 PMID:23090186 PMID:19048273 PMID:32535406

RGD:2308804, RGD:401850547

NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407

G

somatostatin receptor 1

RGD

NCBI chr12:58,258,524...58,262,822
Ensembl chr12:58,258,558...58,260,673

G

somatostatin receptor 2

RGD

NCBI chr11:113,510,153...113,516,854
Ensembl chr11:113,510,168...113,516,854

G

somatostatin receptor 3

RGD

NCBI chr15:78,421,214...78,433,565
Ensembl chr15:78,421,208...78,428,885

G

somatostatin receptor 5

RGD

NCBI chr17:25,708,849...25,716,262
Ensembl chr17:25,708,847...25,733,577

G

steroidogenic acute regulatory protein

mRNA:decreased expression:sciatic nerve (rat)

RGD

NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010

G

signal transducer and activator of transcription 1

protein:increased tyrosine phosphorylation:glomerulus

RGD

NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024

G

signal transducer and activator of transcription 3

protein:increased tyrosine phosphorylation:aorta endothelium

RGD

PMID:18230613 PMID:22660795

RGD:2291921, RGD:8694292

NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366

G

signal transducer and activator of transcription 4

RGD

NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348

G

signal transducer and activator of transcription 5B

RGD

NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550

G

stimulated by retinoic acid gene 6

protein:decreased expression:optic cup (rat)

RGD

NCBI chr 9:57,971,076...58,061,287
Ensembl chr 9:57,971,071...58,061,279

G

steroid sulfatase

CTD Direct Evidence: therapeutic

NCBI chr X:168,856,332...169,015,037
Ensembl chr X:168,909,030...169,014,924

G

telomerase reverse transcriptase

RGD

NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962

G

transforming growth factor, beta 1

protein:increased expression:urine
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17177138 PMID:23090186 PMID:15855808

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

transforming growth factor, beta 2

protein:increased expression:parotid gland

RGD

NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186

G

tyrosine hydroxylase

protein:increased expression:seminal vesicle

RGD

NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865

G

thrombospondin 1

RGD

NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614

G

translocase of inner mitochondrial membrane 44

protein:decreased expression:retina

RGD

NCBI chr 8:4,309,731...4,325,905
Ensembl chr 8:4,309,731...4,325,913

G

tissue inhibitor of metalloproteinase 1

protein:increased expression:kidney
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21963884 PMID:17569353 PMID:17192464

RGD:2290354, RGD:2312467

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

tissue inhibitor of metalloproteinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566

G

tissue inhibitor of metalloproteinase 3

mRNA:increased expression:glomerulus

RGD

NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370

G

tight junction protein 1

protein:decreased expression:glomerulus

RGD

NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529

G

toll-like receptor 2

RGD

PMID:16740310 PMID:17707128

RGD:2312491, RGD:2312684

NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074

G

toll-like receptor 4

RGD

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

tenascin C

RGD

NCBI chr 4:63,878,022...63,965,554
Ensembl chr 4:63,878,022...63,965,252

G

tumor necrosis factor

treatment

protein:increased expression:heart
CTD Direct Evidence: marker/mechanism
protein:increased expression:liver

CTD
RGD

PMID:12123627 PMID:12193562 PMID:19478208 PMID:20388520 PMID:22138235 More...

RGD:4142788, RGD:2312478, RGD:10450575, RGD:5131250

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 1a

protein:increased expression:liver (rat)
CTD Direct Evidence: therapeutic

CTD
RGD

PMID:12193562 PMID:21481476

NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447

G

tumor necrosis factor receptor superfamily, member 1b

human protein in rat model

RGD

NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440

G

tumor necrosis factor (ligand) superfamily, member 10

RGD

PMID:12577054 PMID:18649770 PMID:19572802

RGD:2312744, RGD:2312738, RGD:2312737

NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576

G

translocase of outer mitochondrial membrane 40

protein:decreased expression:retina

RGD

NCBI chr 7:19,435,238...19,449,370
Ensembl chr 7:19,435,238...19,449,363

G

translocase of outer mitochondrial membrane 70A

protein:decreased expression:retina

RGD

NCBI chr16:56,942,077...56,974,893
Ensembl chr16:56,942,066...56,977,068

G

triosephosphate isomerase 1

protein:decreased expression:retina

RGD

NCBI chr 6:124,787,549...124,791,121
Ensembl chr 6:124,787,549...124,791,259

G

three prime repair exonuclease 2

RGD

NCBI chr X:72,477,311...72,478,949
Ensembl chr X:72,477,311...72,478,950

G

transferrin

RGD

NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643

G

transformation related protein 53

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21078376 PMID:23792339 PMID:24828139

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

transformation related protein 63

protein:increased expression:prostate gland

RGD

NCBI chr16:25,502,513...25,710,842
Ensembl chr16:25,502,513...25,710,852

G

transient receptor potential cation channel, subfamily C, member 1

mRNA:decreased expression:kidney, liver

RGD

NCBI chr 9:95,587,125...95,632,438
Ensembl chr 9:95,587,135...95,632,428

G

TSC complex subunit 2

protein:increased threonine phosphorylation:cortex of kidney

RGD

NCBI chr17:24,814,788...24,851,607
Ensembl chr17:24,814,790...24,851,604

G

twinkle mtDNA helicase

mRNA,protein:decreased expression:retina,mitochondrion:

RGD

PMID:22743328 PMID:22229649

RGD:8694093, RGD:8694187

NCBI chr19:44,994,102...45,001,203
Ensembl chr19:44,994,102...45,001,201

G

thioredoxin 1

mRNA:altered expression:myocardium (rat)

RGD

NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411

G

thioredoxin 2

mRNA:increased expression:glomerulus
mRNA:altered expression:myocardium (rat)

RGD

PMID:15039483 PMID:20571744

RGD:2306161, RGD:5133714

NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206

G

thioredoxin interacting protein

protein:increased expression:kidney

RGD

NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199

G

thioredoxin reductase 1

mRNA:altered expression:myocardium (rat)

RGD

NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546

G

thioredoxin reductase 2

mRNA:altered expression:myocardium (rat)

RGD

NCBI chr16:18,245,167...18,297,823
Ensembl chr16:18,245,134...18,297,823

G

ubiquitin A-52 residue ribosomal protein fusion product 1

mRNA:increased expression:kidney (mouse)

RGD

NCBI chr 8:70,960,913...70,963,067
Ensembl chr 8:70,960,913...70,963,451

G

ubiquitin carboxyl-terminal esterase L5

RGD

NCBI chr 1:143,652,993...143,683,204
Ensembl chr 1:143,653,010...143,683,204

G

uridine-cytidine kinase 2

protein:decreased activity:heart, skeletal muscle

RGD

NCBI chr 1:167,050,464...167,112,657
Ensembl chr 1:167,050,452...167,112,889

G

uncoupling protein 2 (mitochondrial, proton carrier)

protein:increased expression:kidney
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:14563825 PMID:16123366 PMID:19227473

NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227

G

uncoupling protein 3 (mitochondrial, proton carrier)

susceptibility

mRNA:increased expression:skeletal muscle

RGD

PMID:12079841 PMID:10868941

RGD:2313520, RGD:2313524

NCBI chr 7:100,122,198...100,135,639
Ensembl chr 7:100,122,197...100,135,639

G

UDP glucuronosyltransferase 2 family, polypeptide B1

mRNA:increased expression:liver

RGD

NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389

G

uromodulin

protein:increased expression:urine

RGD

NCBI chr 7:119,061,931...119,078,485
Ensembl chr 7:119,061,934...119,078,505

G

uridine monophosphate synthetase

protein:decreased activity:liver (rat)
protein:decreased activity:mammary gland (rat)

RGD

PMID:3907307 PMID:1476792

RGD:5132278, RGD:5132591

NCBI chr16:33,775,152...33,787,408
Ensembl chr16:33,775,152...33,787,408

G

uracil phosphoribosyltransferase

protein:decreased activity:mammary gland (rat)

RGD

NCBI chr X:103,526,409...103,555,829
Ensembl chr X:103,526,424...103,551,096

G

urotensin 2 receptor

RGD

NCBI chr11:121,051,097...121,052,799
Ensembl chr11:121,051,097...121,052,799

G

vascular cell adhesion molecule 1

mRNA, protein:increased expression:kidney
mRNA:increased expression:aorta

RGD

PMID:18983856 PMID:18093596

RGD:2312764, RGD:2306988

NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337

G

voltage-dependent anion channel 1

protein:increased expression:kidney

RGD

NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224

G

vascular endothelial growth factor A

mRNA:decreased expression:skeletal muscle
CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:heart

CTD
RGD

PMID:22191573 PMID:16816123 PMID:19934008 PMID:16741021

RGD:2313725, RGD:7421582, RGD:2313724

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

vascular endothelial growth factor B

mRNA:decreased expression:skeletal muscle

RGD

NCBI chr19:6,959,840...6,965,019
Ensembl chr19:6,959,841...6,965,019

G

vasoactive intestinal polypeptide

RGD

NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617

G

vasoactive intestinal peptide receptor 1

RGD

NCBI chr 9:121,471,782...121,502,020
Ensembl chr 9:121,471,782...121,502,020

G

very low density lipoprotein receptor

protein:decreased expression:heart, skeletal muscle

RGD

NCBI chr19:27,190,070...27,231,631
Ensembl chr19:27,193,884...27,231,631

G

Von Willebrand factor

protein:increased expression:plasma

RGD

NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642

G

WD repeat domain 35

mRNA:increased expression:kidney (rat)

RGD

NCBI chr12:9,023,897...9,078,848
Ensembl chr12:9,023,892...9,078,847

G

xanthine dehydrogenase

protein:increased expression:brain, heart, kidney

RGD

NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide

CTD Direct Evidence: therapeutic

NCBI chr 5:33,176,160...33,185,310
Ensembl chr 5:33,176,160...33,185,310

Term paths to the root

Path 1
Term	Annotations
disease	16263
Animal Diseases	1462
Animal Disease Models	1413
Experimental Diabetes Mellitus	596
Path 2
Term	Annotations
disease	16263
Developmental Disease	14070
Congenital, Hereditary, and Neonatal Diseases and Abnormalities	13128
genetic disease	12819
inherited metabolic disorder	6071
carbohydrate metabolic disorder	2963
glucose metabolism disease	1685
diabetes mellitus	1455
Experimental Diabetes Mellitus	596

paths to the root