RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Experimental Diabetes Mellitus
Accession: DOID:9005643
Definition: Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
Synonyms: exact_synonym: Alloxan Diabetes; Experimental Diabetes Mellitus; Streptozocin Diabete; streptozocin diabetes; streptozotocin diabetes primary_id: MESH:D003921
G
AACS
acetoacetyl-CoA synthetase
ISO
protein:decreased activity:liver
RGD
PMID:12034369 RGD:2301022
NCBI chr12:125,065,435...125,143,316
G
AANAT
aralkylamine N-acetyltransferase
ISO
RGD
PMID:18624957 RGD:2301030
NCBI chr17:76,453,351...76,470,117
G
ABAT
4-aminobutyrate aminotransferase
ISO
RGD
PMID:9846053 RGD:1598518
NCBI chr16:8,674,617...8,784,570
G
ABCB1
ATP binding cassette subfamily B member 1
disease_progression
ISO
protein: decreased expression
RGD
PMID:17074306 PMID:17664251 PMID:26460146 PMID:21685928 RGD:1598559 , RGD:2312730 , RGD:11041112 , RGD:8657121
NCBI chr 7:87,503,017...87,713,295
G
ABCB4
ATP binding cassette subfamily B member 4
ISO
RGD
PMID:12055592 RGD:1598588
NCBI chr 7:87,365,896...87,476,027
G
ABCC2
ATP binding cassette subfamily C member 2
ISO
protein: increased expression
RGD
PMID:19356064 PMID:20487213 PMID:17664251 RGD:2312728 , RGD:11541075 , RGD:2312730
NCBI chr10:99,782,640...99,852,594
G
ABCC3
ATP binding cassette subfamily C member 3
ISO
mRNA:increased expression:liver
RGD
PMID:20487213 RGD:11541075
NCBI chr17:50,634,881...50,692,253
G
ABCC9
ATP binding cassette subfamily C member 9
ISO
mRNA, protein:decreased expression:heart
RGD
PMID:22257425 RGD:12792003
NCBI chr12:21,797,389...21,941,426
G
ABCG2
ATP binding cassette subfamily G member 2 (JR blood group)
ISO
protein:decreased expression:cerebral cortex
RGD
PMID:17915193 RGD:2315584
NCBI chr 4:88,090,264...88,231,626
G
ABCG5
ATP binding cassette subfamily G member 5
ISO
RGD
PMID:14618236 RGD:1558629
NCBI chr 2:43,806,211...43,839,231
G
ABCG8
ATP binding cassette subfamily G member 8
ISO
RGD
PMID:14618236 RGD:1558629
NCBI chr 2:43,838,971...43,882,988
G
ACAA1
acetyl-CoA acyltransferase 1
ISO
mRNA:increased expression: heart
RGD
PMID:17632588 RGD:2313044
NCBI chr 3:38,122,715...38,137,127
G
ACADVL
acyl-CoA dehydrogenase very long chain
ISO
protein:decreased expression:brain
RGD
PMID:25260493 RGD:10047114
NCBI chr17:7,217,125...7,225,266
G
ACE
angiotensin I converting enzyme
ISO EXP
protein:increased expression:kidney
CTD PMID:22191573 PMID:18679036 RGD:2313799
NCBI chr17:63,477,061...63,498,373
G
ACE2
angiotensin converting enzyme 2
ISO
protein:altered expression:kidney
RGD
PMID:18679036 RGD:2313799
NCBI chr X:15,518,197...15,607,211
G
ACHE
acetylcholinesterase (Yt blood group)
treatment
ISO
protein:increased expression:blood
RGD
PMID:19296211 PMID:1385785 PMID:19347982 PMID:19303406 RGD:2312432 , RGD:2312437 , RGD:150517552 , RGD:2312430
NCBI chr 7:100,889,994...100,896,994
G
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
treatment
ISO
RGD
PMID:12042425 PMID:19169727 RGD:13831125 , RGD:13831126
NCBI chr 2:134,838,616...134,902,034
G
ACOT1
acyl-CoA thioesterase 1
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:14563825
NCBI chr14:73,490,933...73,543,796
G
ACOT2
acyl-CoA thioesterase 2
ISO
protein:increased expression:heart, mitochondrion (rat)
RGD
PMID:17438340 RGD:2315861
NCBI chr14:73,567,620...73,575,658
G
ACOX1
acyl-CoA oxidase 1
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:14563825
NCBI chr17:75,941,507...75,979,166
G
ACP5
acid phosphatase 5, tartrate resistant
ISO
protein:increased activity:femoral bone (rat)
RGD
PMID:19699734 RGD:2315882
NCBI chr19:11,574,660...11,578,975
G
ACSL1
acyl-CoA synthetase long chain family member 1
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:9452481
NCBI chr 4:184,755,595...184,826,594
G
ACSL3
acyl-CoA synthetase long chain family member 3
ISO
RGD
PMID:21136146 RGD:13831298
NCBI chr 2:222,861,036...222,944,639
G
ACSL6
acyl-CoA synthetase long chain family member 6
ISO
mRNA:decreased expression:heart
RGD
PMID:16428347 RGD:1599808
NCBI chr 5:131,949,973...132,012,213
G
ADA
adenosine deaminase
ISO
protein:increased expression:platelet
RGD
PMID:19166862 PMID:9784839 RGD:2313538 , RGD:2313540
NCBI chr20:44,619,522...44,651,699
G
ADCYAP1
adenylate cyclase activating polypeptide 1
ISO
protein:increased expression:pancreas, hypothalamus
RGD
PMID:9864055 RGD:2325314
NCBI chr18:904,411...912,172
G
ADIPOQ
adiponectin, C1Q and collagen domain containing
ISO
mRNA, protein:decreased expression:adipose tissue, serum
RGD
PMID:16201273 PMID:23174569 RGD:1599146 , RGD:8694416
NCBI chr 3:186,842,710...186,858,463
G
ADIPOR2
adiponectin receptor 2
no_association
ISO
No change in Adipor2 expression in rat heart in streptozotocin induced diabetic rats
RGD
PMID:17884446 PMID:18222103 PMID:19220660 RGD:2312495 , RGD:2312488 , RGD:2312478
NCBI chr12:1,691,070...1,788,674
G
ADK
adenosine kinase
ISO
protein:decreased expression:spleen, lymphocyte
RGD
PMID:12729803 RGD:2313360
NCBI chr10:74,151,221...74,709,290
G
ADM
adrenomedullin
ISO
protein:increased expression:pigmented epithelial cell, retina
RGD
PMID:16955796 RGD:1625296
NCBI chr11:10,305,073...10,307,397
G
ADORA1
adenosine A1 receptor
treatment
ISO
associated with hypertension
RGD
PMID:11593763 PMID:9597368 PMID:19276628 PMID:16256246 RGD:2313808 , RGD:1625365 , RGD:2313804 , RGD:2313805
NCBI chr 1:203,127,726...203,167,405
G
ADORA2A
adenosine A2a receptor
ISO
protein:increased expression:hippocampus
RGD
PMID:16256246 RGD:2313805
NCBI chr22:24,423,597...24,442,357
G
ADRA1A
adrenoceptor alpha 1A
ISO EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:19133277 PMID:17054657 RGD:1625775
NCBI chr 8:26,748,150...26,867,379
G
ADRB1
adrenoceptor beta 1
ISO
protein:decreased expression:left ventricle muscular part
RGD
PMID:21054861 RGD:5129115
NCBI chr10:114,043,866...114,046,904
G
ADRB3
adrenoceptor beta 3
ISO EXP
protein:increased expression:left ventricle muscular part
CTD PMID:17622774 PMID:21054861 RGD:5129115
NCBI chr 8:37,962,990...37,966,599
G
ADSL
adenylosuccinate lyase
ISO
protein:increased activity:heart (rat)
RGD
PMID:3360219 RGD:1598762
NCBI chr22:40,346,500...40,387,527
G
ADSS1
adenylosuccinate synthase 1
ISO
protein:increased activity:heart (rat)
RGD
PMID:3360219 RGD:1598762
NCBI chr14:104,724,229...104,747,325
G
AGER
advanced glycosylation end-product specific receptor
treatment
ISO
protein:increased expression:lacrimal gland
RGD
PMID:16283249 PMID:34018385 PMID:22476978 PMID:21458563 PMID:20801062 RGD:1625335 , RGD:597621665 , RGD:7245558 , RGD:7244188 , RGD:7243964
NCBI chr 6:32,180,969...32,184,253
G
AGT
angiotensinogen
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:15831366 PMID:17177138 PMID:18829990
NCBI chr 1:230,702,523...230,745,583
G
AGTR2
angiotensin II receptor type 2
ISO
mRNA, protein:decreased expression:kidney
RGD
PMID:12172324 RGD:6903861
NCBI chr X:116,170,744...116,174,974
G
AIFM1
apoptosis inducing factor mitochondria associated 1
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:23499715
NCBI chr X:130,129,362...130,165,841
G
AIRE
autoimmune regulator
susceptibility
ISO
RGD
PMID:18399912 RGD:2306853
NCBI chr21:44,285,876...44,298,648
G
AKR1B1
aldo-keto reductase family 1 member B
ISO
mRNA:increased expression:kidney (rat)
RGD
PMID:8204669 RGD:8548781
NCBI chr 7:134,442,350...134,459,239
G
AKT1
AKT serine/threonine kinase 1
treatment
ISO
protein:decreased serine phosphorylation:cornea
RGD
PMID:21330660 PMID:29379801 PMID:18599524 RGD:5131482 , RGD:408346751 , RGD:8657153
NCBI chr14:104,769,349...104,795,748
G
ALAD
aminolevulinate dehydratase
susceptibility
ISO IEP
protein:decreased activity:liver, kidney (rat)
RGD
PMID:19043199 PMID:10224671 PMID:18668330 PMID:21864646 PMID:24947461 PMID:7728901 More...
RGD:4144150 , RGD:15039405 , RGD:12904704 , RGD:12904702 , RGD:12904692 , RGD:12904683
NCBI chr 9:113,386,312...113,401,284
G
ALAS1
5'-aminolevulinate synthase 1
ISO
protein:decreased activity:liver (rat)
RGD
PMID:6688350 RGD:4144808
NCBI chr 3:52,198,083...52,214,327
G
ALDOB
aldolase, fructose-bisphosphate B
ISO
mRNA:reduced expression:liver, small intestine (rat)
RGD
PMID:2984252 RGD:2313437
NCBI chr 9:101,420,560...101,435,774
G
ANGPT1
angiopoietin 1
ISO
protein:increased expression:retina
RGD
PMID:15047628 PMID:17294737 RGD:2313817 , RGD:1626163
NCBI chr 8:107,249,482...107,497,918
G
ANGPT2
angiopoietin 2
ISO
protein:increased expression:retina
RGD
PMID:15047628 RGD:2313817
NCBI chr 8:6,499,632...6,563,245
G
ANGPTL3
angiopoietin like 3
ISO
protein:increased expression:liver
RGD
PMID:15094378 RGD:2314234
NCBI chr 1:62,597,520...62,606,313
G
ANXA1
annexin A1
ISO
protein:increased glycation:respiratory system blood vessel endothelium
RGD
PMID:11423489 RGD:2306888
NCBI chr 9:73,151,865...73,170,393
G
ANXA2
annexin A2
ISO
protein:increased glycation:respiratory system blood vessel endothelium
RGD
PMID:11423489 RGD:2306888
NCBI chr15:60,347,151...60,397,986
G
AOC1
amine oxidase copper containing 1
ISO
RGD
PMID:1632778 RGD:2312809
NCBI chr 7:150,852,120...150,861,504
G
AOC3
amine oxidase copper containing 3
ISO EXP
protein:increased expression:kidney, serum
CTD PMID:14977883 PMID:2218072 PMID:19635478 PMID:12606817 RGD:2313828 , RGD:2313819 , RGD:2313824
NCBI chr17:42,851,199...42,858,124
G
APOA1
apolipoprotein A1
treatment
ISO
RGD
PMID:17488882 RGD:7241577
NCBI chr11:116,835,751...116,837,622
G
APOB
apolipoprotein B
ISO
RGD
PMID:17292734 RGD:1642185
NCBI chr 2:21,001,429...21,044,073
G
APOE
apolipoprotein E
ISO
protein:decreased expression:plasma (rat)
RGD
PMID:16947119 RGD:1599198
NCBI chr19:44,905,796...44,909,393
G
APOM
apolipoprotein M
ISO
protein:decreased secretion:plasma
RGD
PMID:16516154 RGD:2314249
NCBI chr 6:31,652,404...31,658,210
G
APRT
adenine phosphoribosyltransferase
ISO
protein:decreased activity:mammary gland (rat)
RGD
PMID:2451510 RGD:1599204
NCBI chr16:88,809,339...88,811,928
G
AQP1
aquaporin 1 (Colton blood group)
ISO
protein:increased expression:retina
RGD
PMID:19596320 RGD:2316078
NCBI chr 7:30,911,853...30,925,516
G
AQP2
aquaporin 2
ISO
protein:increased expression:Kidney Medulla
RGD
PMID:11380083 PMID:15705184 RGD:2314347 , RGD:2314326
NCBI chr12:49,950,737...49,958,878
G
AQP4
aquaporin 4
ISO
mRNA,protein:increased expression:retina:
RGD
PMID:22449442 RGD:8695996
NCBI chr18:26,852,038...26,865,803
G
AR
androgen receptor
treatment
ISO
protein:decreased expression:pancreatic B cell
RGD
PMID:18543106 PMID:31838605 PMID:16398356 RGD:2306772 , RGD:407424618 , RGD:2306774
NCBI chr X:67,544,021...67,730,619
G
ARG1
arginase 1
ISO
protein:increased expression:aorta, liver (rat)
RGD
PMID:17967788 RGD:4142848
NCBI chr 6:131,573,226...131,584,329
G
ARG2
arginase 2
ISO
protein:increased activity:kidney (rat)
RGD
PMID:12841630 RGD:4143269
NCBI chr14:67,619,920...67,651,708
G
ASPA
aspartoacylase
ISO
protein:increased expression:duodenum, brain
RGD
PMID:16707098 RGD:1601247
NCBI chr17:3,474,110...3,503,405
G
ASS1
argininosuccinate synthase 1
ISO
mRNA, protein:increased expression:aorta (rat)
RGD
PMID:11384198 RGD:1599310
NCBI chr 9:130,444,707...130,501,274
G
ATF3
activating transcription factor 3
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:16123366
NCBI chr 1:212,565,407...212,620,777
G
ATG7
autophagy related 7
treatment
ISO
protein:decreased expression:myocardium
RGD
PMID:24874076 PMID:24993523 RGD:11557993 , RGD:11557996
NCBI chr 3:11,272,397...11,576,353
G
ATP2A1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
ISO
RGD
PMID:28483572 RGD:12910731
NCBI chr16:28,878,488...28,904,466
G
ATP2A2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
ISO EXP
protein:increased carbonylation:heart
CTD PMID:16123366 PMID:21300842 PMID:20122173 PMID:28483572 RGD:6904139 , RGD:13782130 , RGD:12910731
NCBI chr12:110,280,616...110,351,093
G
ATP2A3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
EXP ISO
CTD Direct Evidence: marker/mechanism
CTD PMID:16123366 PMID:20122173 RGD:13782130
NCBI chr17:3,923,873...3,964,437
G
ATP4B
ATPase H+/K+ transporting subunit beta
ISO
RGD
PMID:20237950 RGD:14696743
NCBI chr13:113,648,804...113,658,198
G
ATP5F1A
ATP synthase F1 subunit alpha
ISO
protein:decreased expression:cerebral cortex, mitochondrion (rat)
RGD
PMID:28526935 RGD:13703047
NCBI chr18:46,080,248...46,104,227
G
ATP5F1B
ATP synthase F1 subunit beta
ISO
associated with polycystic ovary syndrome;mRNA, protein:decreased expression:pancreas (rat)
RGD
PMID:28397049 RGD:13703107
NCBI chr12:56,638,175...56,645,984
G
ATP5PD
ATP synthase peripheral stalk subunit d
ISO
protein:decreased expression:retina (rat)
RGD
PMID:17465459 RGD:5147874
NCBI chr17:75,038,863...75,046,969
G
ATP5PF
ATP synthase peripheral stalk subunit F6
treatment
ISO
RGD
PMID:28731155 RGD:13800891
NCBI chr21:25,724,500...25,735,653
G
AVP
arginine vasopressin
ISO
mRNA:increased expression:hypothalamus
RGD
PMID:18420743 RGD:2301919
NCBI chr20:3,082,556...3,084,724
G
BAD
BCL2 associated agonist of cell death
ISO
protein:increased expression, decreased phosphorylation, altered activity:testis
RGD
PMID:17870134 PMID:21330660 RGD:2292685 , RGD:5131482
NCBI chr11:64,269,828...64,284,704
G
BAX
BCL2 associated X, apoptosis regulator
treatment
ISO EXP
protein:increased expression:retina
CTD PMID:23090186 PMID:18991018 PMID:23267840 RGD:2311240 , RGD:10054099
NCBI chr19:48,954,875...48,961,798
G
BCHE
butyrylcholinesterase
ISO
protein:decreased expression:retina
RGD
PMID:11478742 PMID:12379509 PMID:16187484 RGD:2306783 , RGD:2306781 , RGD:1599458
NCBI chr 3:165,772,904...165,837,423
G
BCKDHA
branched chain keto acid dehydrogenase E1 subunit alpha
ISO
protein:increased expression:liver
RGD
PMID:9460082 RGD:1599467
NCBI chr19:41,397,818...41,425,002
G
BCKDHB
branched chain keto acid dehydrogenase E1 subunit beta
ISO
Protein:increased expression:liver;
RGD
PMID:9460082 RGD:1599467
NCBI chr 6:80,106,610...80,466,676
G
BCL2
BCL2 apoptosis regulator
ISO EXP
mRNA:decreased expression:embryo
CTD PMID:16959961 PMID:23090186 PMID:15649569 PMID:18991018 RGD:1599491 , RGD:2311240
NCBI chr18:63,123,346...63,320,090
G
BCL2L1
BCL2 like 1
ISO EXP
protein:decreased expression, altered activity:testis
CTD PMID:16959961 PMID:17870134 RGD:2292685
NCBI chr20:31,664,452...31,723,963
G
BDH1
3-hydroxybutyrate dehydrogenase 1
ISO
protein:decreased activity:heart, mitochondrion (rat)
RGD
PMID:3548709 RGD:2326100
NCBI chr 3:197,509,783...197,573,343
G
BDKRB1
bradykinin receptor B1
ISO EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:21430409 PMID:12522068 PMID:20092893 PMID:12489796 RGD:704380 , RGD:7241569 , RGD:704379
NCBI chr14:96,256,210...96,264,763
G
BDKRB2
bradykinin receptor B2
ISO
mRNA:increased expression:heart
RGD
PMID:12489796 PMID:16138314 RGD:704379 , RGD:4890452
NCBI chr14:96,204,839...96,244,164
G
BDNF
brain derived neurotrophic factor
treatment
ISO
RGD
PMID:24857910 PMID:30816461 RGD:10059399 , RGD:596936233
NCBI chr11:27,654,893...27,722,030
G
BECN1
beclin 1
treatment
ISO
RGD
PMID:24993523 RGD:11557996
NCBI chr17:42,810,132...42,824,282
G
BGLAP
bone gamma-carboxyglutamate protein
ISO
protein:reduced expression:serum (rat)
RGD
PMID:19494718 RGD:2316184
NCBI chr 1:156,242,184...156,243,317
G
BMAL1
basic helix-loop-helix ARNT like 1
ISO
RGD
PMID:18624957 RGD:2301030
NCBI chr11:13,276,652...13,387,266
G
BMPR2
bone morphogenetic protein receptor type 2
ISO
protein:increased expression:lung
RGD
PMID:21521772 RGD:5135278
NCBI chr 2:202,376,327...202,567,749
G
BTC
betacellulin
IDA ISO IMP
RGD
PMID:14988244 PMID:19819964 PMID:18388935 RGD:1357906 , RGD:2313774 , RGD:2306965
NCBI chr 4:74,744,759...74,794,523
G
CACNG4
calcium voltage-gated channel auxiliary subunit gamma 4
ISO
mRNA:decreased expression:sinoatrial node:
RGD
PMID:27096430 RGD:13524560
NCBI chr17:66,964,707...67,033,398
G
CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
ISO
protein:decreased activity:mammary gland (rat)
RGD
PMID:1476792 RGD:5132591
NCBI chr 2:27,217,369...27,243,943
G
CALCA
calcitonin related polypeptide alpha
ISO
protein:increased expression:penis erectile tissue, seminal vesicle
RGD
PMID:19152794 PMID:17151309 RGD:2314033 , RGD:2314035
NCBI chr11:14,966,668...14,972,351
G
CALD1
caldesmon 1
ISO
RGD
PMID:10644879 RGD:2314036
NCBI chr 7:134,745,467...134,970,729
G
CAPN10
calpain 10
ISO
mRNA, protein:decreased expression:kidney cortex
RGD
PMID:22568896 RGD:7247732
NCBI chr 2:240,586,734...240,599,104
G
CARHSP1
calcium regulated heat stable protein 1
treatment
ISO
RGD
PMID:19997081 RGD:39128203
NCBI chr16:8,852,942...8,869,006
G
CASP1
caspase 1
ISO
mRNA:increased expression:retina
RGD
PMID:18398369 RGD:2315888
NCBI chr11:105,025,443...105,036,686
G
CASP3
caspase 3
treatment
ISO EXP
protein:increased activity:hypothalamus
CTD PMID:20654064 PMID:19094082 PMID:28843149 RGD:2311447 , RGD:13782300
NCBI chr 4:184,627,696...184,649,447
G
CASP6
caspase 6
ISO
protein:increased activity:heart left ventricle
RGD
PMID:15662549 RGD:2301316
NCBI chr 4:109,664,388...109,709,767
G
CASP8
caspase 8
treatment
ISO
protein:increased activity, increased expression:pituitary gland, prolactin secreting cell
RGD
PMID:15976052 PMID:28843149 PMID:19540304 PMID:17563067 RGD:2311319 , RGD:13782300 , RGD:2311427 , RGD:2311429
NCBI chr 2:201,233,463...201,287,711
G
CASP9
caspase 9
ISO
protein:increased activity, increased expression:pituitary gland
RGD
PMID:15976052 RGD:2311319
NCBI chr 1:15,491,401...15,524,912
G
CASQ1
calsequestrin 1
ISO
protein:increased activity:skeletal muscle tissue
RGD
PMID:11976916 RGD:2314137
NCBI chr 1:160,190,575...160,201,886
G
CASR
calcium sensing receptor
ISO
protein:increased expression:pancreas, liver, kidney (rat)
RGD
PMID:22844268 RGD:7205442
NCBI chr 3:122,183,668...122,291,629
G
CAT
catalase
ISO EXP
associated with alcohol use disorder; protein:decreased activity;testis, epididymis (rat)
CTD PMID:12123627 PMID:15855331 PMID:20709041 PMID:20376213 PMID:25541261 RGD:5130772 , RGD:405255664
NCBI chr11:34,438,934...34,472,060
G
CAV1
caveolin 1
ISO EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:18266981 PMID:25086377 RGD:10045572
NCBI chr 7:116,525,009...116,561,185
G
CAV3
caveolin 3
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:18266981
NCBI chr 3:8,733,802...8,746,758
G
CBR1
carbonyl reductase 1
ISO
protein:decreased expression:pancreas (rat)
RGD
PMID:18452227 RGD:2302233
NCBI chr21:36,070,024...36,073,164
G
CCK
cholecystokinin
ISO
RGD
PMID:15536283 RGD:2313638
NCBI chr 3:42,257,826...42,266,185
G
CCKBR
cholecystokinin B receptor
ISO
mRNA, protein:decreased expression:pancreas
RGD
PMID:15161757 RGD:1358452
NCBI chr11:6,259,838...6,272,127
G
CCL2
C-C motif chemokine ligand 2
treatment
ISO
protein:increased expression:gingiva
RGD
PMID:17876613 PMID:16891764 PMID:18976114 RGD:2306992 , RGD:8549535 , RGD:2306984
NCBI chr17:34,255,285...34,257,203
G
CCL20
C-C motif chemokine ligand 20
EXP
CTD Direct Evidence: therapeutic
CTD PMID:21340626
NCBI chr 2:227,813,842...227,817,556
G
CCN1
cellular communication network factor 1
ISO
mRNA:increased expression:retina (mouse)
RGD
PMID:22160564 RGD:329845551
NCBI chr 1:85,580,761...85,583,950
G
CCN2
cellular communication network factor 2
treatment
ISO
mRNA, protein:increased expression:heart, myocardium (rat)
RGD
PMID:19820199 PMID:34018385 PMID:19625611 RGD:2314021 , RGD:597621665 , RGD:2314487
NCBI chr 6:131,948,176...131,951,372
G
CCNA2
cyclin A2
ISO
RGD
PMID:20031167 RGD:2316310
NCBI chr 4:121,816,444...121,823,883
G
CCNB1
cyclin B1
ISO
mRNA:decreased expression:liver (rat)
RGD
PMID:20031167 RGD:2316310
NCBI chr 5:69,167,150...69,178,245
G
CCND3
cyclin D3
ISO
protein:increased expression:kidney, glomerulus
RGD
PMID:19276076 RGD:2316018
NCBI chr 6:41,934,933...42,050,035
G
CCNT1
cyclin T1
ISO
mRNA,protein:decreased expression:liver:
RGD
PMID:20828602 RGD:9698426
NCBI chr12:48,688,458...48,716,707
G
CCR5
C-C motif chemokine receptor 5
ISO
protein:increased expression:retina
RGD
PMID:21575160 RGD:11533943
NCBI chr 3:46,370,142...46,376,206
G
CD28
CD28 molecule
ISO
RGD
PMID:11160314 RGD:2307200
NCBI chr 2:203,706,482...203,738,912
G
CD36
CD36 molecule (CD36 blood group)
treatment
ISO
mRNA:increased expression:multiple organs
RGD
PMID:16838191 PMID:23691525 RGD:2307214 , RGD:11041145
NCBI chr 7:80,602,207...80,679,274
G
CD3E
CD3 epsilon subunit of T-cell receptor complex
ISO
RGD
PMID:16628253 RGD:2314179
NCBI chr11:118,304,730...118,316,173
G
CD40LG
CD40 ligand
treatment
ISO
protein:increased expression:platelet (rat)
RGD
PMID:21831422 PMID:19237211 RGD:11352661 , RGD:2312338
NCBI chr X:136,648,158...136,660,390
G
CD68
CD68 molecule
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:20388520
NCBI chr17:7,579,638...7,582,111
G
CD80
CD80 molecule
ISO
RGD
PMID:11160314 RGD:2307200
NCBI chr 3:119,524,293...119,559,614
G
CD86
CD86 molecule
ISO
RGD
PMID:8993020 RGD:2313930
NCBI chr 3:122,055,362...122,121,136
G
CDK9
cyclin dependent kinase 9
ISO
mRNA,protein:decreased expression:liver:
RGD
PMID:20828602 RGD:9698426
NCBI chr 9:127,786,034...127,790,792
G
CDKN1A
cyclin dependent kinase inhibitor 1A
ISO
protein:increased expression:testes:
RGD
PMID:24828139 RGD:8662307
NCBI chr 6:36,676,463...36,687,332
G
CEL
carboxyl ester lipase
ISO
protein:decreased expression:pancreas,
RGD
PMID:8446851 RGD:2313971
NCBI chr 9:133,061,981...133,071,861
G
CFD
complement factor D
ISO
protein:decreased expression:serum
RGD
PMID:8372111 RGD:1624344
NCBI chr19:859,664...863,641
G
CFTR
CF transmembrane conductance regulator
severity
ISO
RGD
PMID:16804061 RGD:2314614
NCBI chr 7:117,480,025...117,668,665
G
CHAT
choline O-acetyltransferase
ISO
protein:decreased expression:telencephalon
RGD
PMID:26282349 RGD:402463971
NCBI chr10:49,609,095...49,667,942
G
CHRM2
cholinergic receptor muscarinic 2
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:18603373
NCBI chr 7:136,868,652...137,020,213
G
CLPS
colipase
ISO
RGD
PMID:19577003 RGD:2314624
NCBI chr 6:35,794,982...35,797,323
G
CLU
clusterin
ISO
protein:increased expression:retina
RGD
PMID:12763621 PMID:23351716 RGD:9068392 , RGD:9068411
NCBI chr 8:27,596,917...27,614,700
G
CMA1
chymase 1
ISO
protein:increased expression:mesenteric artery, mast cell (rat)
RGD
PMID:15337505 RGD:5128799
NCBI chr14:24,505,353...24,508,265
G
CNR1
cannabinoid receptor 1
ISO
protein:increased expression:hypothalamus, striatum
RGD
PMID:18401837 RGD:2314633
NCBI chr 6:88,139,864...88,167,349
G
COMT
catechol-O-methyltransferase
ISO
protein:decreased expression:liver
RGD
PMID:12010186 RGD:2289789
NCBI chr22:19,941,772...19,969,975
G
CP
ceruloplasmin
ISO
Protein:increased expression:plasma
RGD
PMID:16947119 RGD:1599198
NCBI chr 3:149,162,414...149,221,829
G
CPS1
carbamoyl-phosphate synthase 1
ISO
protein:increased activity:liver (rat)
RGD
PMID:2882780 RGD:4144110
NCBI chr 2:210,477,685...210,679,107
G
CPT1A
carnitine palmitoyltransferase 1A
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:16123366
NCBI chr11:68,754,620...68,844,277
G
CPT1B
carnitine palmitoyltransferase 1B
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:14563825
NCBI chr22:50,568,861...50,578,612
G
CRH
corticotropin releasing hormone
ISO
mRNA:increased expression:paraventricular hypothalamic nucleus (rat)
RGD
PMID:9652969 RGD:5508166
NCBI chr 8:66,176,376...66,178,464
G
CRP
C-reactive protein
ISO
RGD
PMID:21736771 PMID:21736794 RGD:6482316 , RGD:6907422
NCBI chr 1:159,712,289...159,714,589
G
CRTC2
CREB regulated transcription coactivator 2
ISO
RGD
PMID:23595987 RGD:9685169
NCBI chr 1:153,947,675...153,958,612
G
CS
citrate synthase
ISO
protein:increased expression:hippocampus
RGD
PMID:21088877 PMID:12077722 RGD:329337352 , RGD:329337354
NCBI chr12:56,271,699...56,300,330
G
CSF1
colony stimulating factor 1
ISO
mRNA,protein:increased expression:retina (rat)
RGD
PMID:19219684 RGD:151665779
NCBI chr 1:109,910,506...109,930,992
G
CSF1R
colony stimulating factor 1 receptor
ISO
mRNA,protein:increased expression:retina (rat)
RGD
PMID:19219684 RGD:151665779
NCBI chr 5:150,053,295...150,113,365
G
CST4
cystatin S
ISO
protein:decreased expression:corpus cavernosum penis (rat)
RGD PMID:20007950 RGD:14696816
NCBI chr20:23,685,640...23,689,038
G
CTSB
cathepsin B
ISO
protein:decreased activity:glomerulus (rat)
RGD
PMID:10393385 RGD:2315531
NCBI chr 8:11,842,524...11,868,087
G
CTSC
cathepsin C
ISO
RGD
PMID:148980 RGD:1599652
NCBI chr11:88,293,592...88,337,736
G
CTSL
cathepsin L
ISO
mRNA:increased expression:gastrocnemius muscle (rat)
RGD
PMID:14718385 RGD:1641826
NCBI chr 9:87,726,119...87,731,469
G
CX3CL1
C-X3-C motif chemokine ligand 1
ISO EXP
mRNA:increased expression:kidney
CTD PMID:20388520 PMID:15153757 RGD:4891992
NCBI chr16:57,372,490...57,385,044
G
CX3CR1
C-X3-C motif chemokine receptor 1
ISO
mRNA:increased expression:kidney
RGD
PMID:15153757 RGD:4891992
NCBI chr 3:39,263,494...39,292,966
G
CXCL10
C-X-C motif chemokine ligand 10
ISO
mRNA:increased expression:pancreatic islet
RGD
PMID:17372021 RGD:2311360
NCBI chr 4:76,021,118...76,023,497
G
CXCL12
C-X-C motif chemokine ligand 12
ISO
protein:increased expression:retina
RGD
PMID:18201529 PMID:17878289 RGD:2306555 , RGD:2306557
NCBI chr10:44,370,165...44,385,097
G
CYBA
cytochrome b-245 alpha chain
ISO EXP
mRNA, protein:increased expression:aorta
CTD PMID:11812764 PMID:12967931 PMID:20226688 PMID:23905384 RGD:2317852 , RGD:11040693
NCBI chr16:88,643,289...88,651,053
G
CYBB
cytochrome b-245 beta chain
ISO EXP
mRNA:increased expression:aorta
CTD PMID:19478208 PMID:11157681 PMID:15148062 RGD:1599691 , RGD:1599683
NCBI chr X:37,780,059...37,813,461
G
CYP11A1
cytochrome P450 family 11 subfamily A member 1
ISO
mRNA:decreased expression:sciatic nerve (rat)
RGD
PMID:20826654 RGD:4145530
NCBI chr15:74,337,762...74,367,646
G
CYP11B1
cytochrome P450 family 11 subfamily B member 1
ISO
mRNA:increased expression:kidney
RGD PMID:18582458 RGD:2307289
NCBI chr 8:142,872,357...142,879,825
G
CYP11B2
cytochrome P450 family 11 subfamily B member 2
ISO
mRNA:increased expression:kidney
RGD
PMID:18582458 RGD:2307289
NCBI chr 8:142,910,559...142,917,843
G
CYP19A1
cytochrome P450 family 19 subfamily A member 1
ISO
protein:decreased expression:ovary, testis (rat)
RGD
PMID:20428845 RGD:4890359
NCBI chr15:51,208,057...51,338,596
G
CYP1A1
cytochrome P450 family 1 subfamily A member 1
ISO EXP
protein:increased expression:liver, microsome (rat)
CTD PMID:22342832 PMID:10711628 RGD:2307074
NCBI chr15:74,719,542...74,725,528
G
CYP27B1
cytochrome P450 family 27 subfamily B member 1
ISO
RGD
PMID:3295473 RGD:2307313
NCBI chr12:57,762,334...57,767,078
G
CYP2B6
cytochrome P450 family 2 subfamily B member 6
ISO
CTD Direct Evidence: marker/mechanism
CTD PMID:22342832
NCBI chr19:40,991,282...41,018,398
G
CYP2E1
cytochrome P450 family 2 subfamily E member 1
ISO
mRNA, protein:increased expression:kidney, liver
RGD
PMID:12700423 PMID:19406192 RGD:2313685 , RGD:2313683
NCBI chr10:133,527,363...133,539,123
G
DBH
dopamine beta-hydroxylase
ISO
mRNA, protein:increased expression:adrenal gland (rat)
RGD
PMID:16396986 RGD:5130724
NCBI chr 9:133,636,363...133,659,329
G
DCN
decorin
ISO
RGD
PMID:15713786 RGD:2311414
NCBI chr12:91,140,484...91,182,817
G
DEFB1
defensin beta 1
ISO
RGD
PMID:16740310 RGD:2312491
NCBI chr 8:6,870,592...6,877,936
G
DHODH
dihydroorotate dehydrogenase (quinone)
ISO
protein:decreased activity:mammary gland (rat)
RGD
PMID:1476792 PMID:1723607 RGD:5132591 , RGD:11040445
NCBI chr16:72,008,744...72,027,659
G
DPP4
dipeptidyl peptidase 4
ISO
RGD
PMID:19765579 RGD:2313699
NCBI chr 2:161,992,245...162,074,215
G
DRD1
dopamine receptor D1
treatment
ISO
protein:decreased activity:striatum (rat)
RGD
PMID:1386820 PMID:20513244 RGD:2311600 , RGD:7248621
NCBI chr 5:175,440,036...175,444,182
G
DRD2
dopamine receptor D2
ISO
protein:altered activity:hypothalamus, pancreatic islet, brainstem (rat)
RGD
PMID:17174299 RGD:1624999
NCBI chr11:113,409,605...113,475,398
G
DUSP1
dual specificity phosphatase 1
ISO
mRNA, protein:decreased expression:ventricle myocardium
RGD
PMID:17647144 PMID:17063547 RGD:2298672 , RGD:7771540
NCBI chr 5:172,768,096...172,771,195
G
ECE1
endothelin converting enzyme 1
ISO
mRNA:increased expression:thoracic aorta
RGD
PMID:23600389 RGD:7243858
NCBI chr 1:21,217,250...21,345,504
G
EDN1
endothelin 1
treatment
ISO EXP
mRNA:increased expression:heart, kidney, retina (rat)
CTD PMID:12458661 PMID:12967931 PMID:18516100 PMID:18351623 PMID:18351623 RGD:2313282 , RGD:2312288 , RGD:2312288
NCBI chr 6:12,230,516...12,297,194
G
EDNRA
endothelin receptor type A
ISO
RGD
PMID:20690982 RGD:4892336
NCBI chr 4:147,481,097...147,544,954
G
EEF2
eukaryotic translation elongation factor 2
treatment
ISO
protein:decreased expression:cardiac muscle:
RGD
PMID:7513958 RGD:10401649
NCBI chr19:3,976,056...3,985,463
G
EGFR
epidermal growth factor receptor
ISO
protein:decreased tyrosine phosphorylation:corneal epithelial cell (rat)
RGD
PMID:21330660 RGD:5131482
NCBI chr 7:55,019,017...55,211,628
G
ELN
elastin
ISO
mRNA:increased expression:bladder:
RGD
PMID:18279932 RGD:9585725
NCBI chr 7:74,028,173...74,069,907
G
ENO2
enolase 2
ISO
protein:increased expression:brain
RGD
PMID:15780189 RGD:2293753
NCBI chr12:6,914,580...6,923,697
G
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
ISO
protein:decreased expression:retina:
RGD
PMID:22864860 RGD:9685437
NCBI chr 8:119,557,086...119,673,390
G
ENTPD1
ectonucleoside triphosphate diphosphohydrolase 1
ISO
protein,mRNA:increased expression:glial cell, retina:
RGD
PMID:18687327 PMID:17119848 RGD:9685473 , RGD:9685486
NCBI chr10:95,694,186...95,877,266
G
EP300
E1A binding protein p300
treatment
ISO
mRNA:increased expression:heart (rat)
RGD
PMID:18657544 PMID:22228707 PMID:18413674 PMID:18351623 RGD:2312287 , RGD:7296926 , RGD:2312263 , RGD:2312288
NCBI chr22:41,092,592...41,180,077
G
EPO
erythropoietin
ISO
mRNA:increased expression:Schwann cell:
RGD
PMID:24673486 RGD:11041670
NCBI chr 7:100,720,468...100,723,700
G
EPOR
erythropoietin receptor
ISO
mRNA:increased expression:Schwann cell:
RGD
PMID:24673486 RGD:11041670
NCBI chr19:11,377,207...11,384,314
G
ERCC1
ERCC excision repair 1, endonuclease non-catalytic subunit
treatment
ISO
RGD
PMID:22228707 RGD:7296926
NCBI chr19:45,407,334...45,451,547
G
ERCC4
ERCC excision repair 4, endonuclease catalytic subunit
treatment
ISO
RGD
PMID:22228707 RGD:7296926
NCBI chr16:13,920,154...13,952,348
G
ESR1
estrogen receptor 1
ISO
protein:decreased expression:vagina,nucleus
RGD
PMID:16734901 PMID:15596216 RGD:2314014 , RGD:2306775
NCBI chr 6:151,656,672...152,129,619
G
ESRRA
estrogen related receptor alpha
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:23090186
NCBI chr11:64,305,524...64,316,743
G
ETS1
ETS proto-oncogene 1, transcription factor
ISO
protein:increased expression:retina
RGD
PMID:17622743 RGD:2313849
NCBI chr11:128,458,765...128,587,558
G
EZH2
enhancer of zeste 2 polycomb repressive complex 2 subunit
ISO
protein:increased expression:kidney
RGD
PMID:23508046 RGD:9587808
NCBI chr 7:148,807,383...148,884,291
G
F11R
F11 receptor
ISO
RGD
PMID:18506084 RGD:7488940
NCBI chr 1:160,995,211...161,021,152
G
F2
coagulation factor II, thrombin
ISO
protein:increased expression:kidney
RGD
PMID:15990447 RGD:2313862
NCBI chr11:46,719,213...46,739,506
G
F3
coagulation factor III, tissue factor
ISO
protein:increased activity:kidney
RGD
PMID:15990447 RGD:2313862
NCBI chr 1:94,529,173...94,541,759
G
F7
coagulation factor VII
ISO
protein:decreased activity:plasma (rat)
RGD
PMID:11474472 PMID:16779662 RGD:2312396 , RGD:2312313
NCBI chr13:113,105,788...113,120,685
G
FABP2
fatty acid binding protein 2
treatment
ISO
RGD
PMID:28085064 RGD:598130069
NCBI chr 4:119,317,250...119,322,138
G
FABP3
fatty acid binding protein 3
ISO
mRNA, protein:decreased expression:aorta
RGD
PMID:7744030 RGD:2307330
NCBI chr 1:31,359,588...31,373,076
G
FABP4
fatty acid binding protein 4
ISO
protein:decreased expresssion:fat cell
RGD
PMID:9059981 RGD:1625411
NCBI chr 8:81,478,419...81,483,233
G
FADS1
fatty acid desaturase 1
ISO
mRNA:decreased expression:liver
RGD
PMID:16099631 RGD:1625413
NCBI chr11:61,799,627...61,817,003
G
FAS
Fas cell surface death receptor
onset
ISO EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:16123366 PMID:20004692 PMID:19820199 RGD:2315698 , RGD:2314021
NCBI chr10:88,964,050...89,017,059
G
FASLG
Fas ligand
ISO
protein:increased expression:heart ventricle
RGD
PMID:19820199 RGD:2314021
NCBI chr 1:172,659,103...172,666,876
G
FBN1
fibrillin 1
ISO
protein:increased expression:renal glomerulus (rat)
RGD
PMID:16380460 RGD:7365080
NCBI chr15:48,408,313...48,645,709
G
FGA
fibrinogen alpha chain
ISO
protein:increased expression:plasma (rat)
RGD
PMID:23086277 RGD:9684989
NCBI chr 4:154,583,126...154,590,742
G
FGF2
fibroblast growth factor 2
ISO
protein:increased expression:vitreous humor
RGD
PMID:12663474 PMID:10792180 RGD:2315880 , RGD:8655613
NCBI chr 4:122,826,682...122,898,236
G
FGF21
fibroblast growth factor 21
treatment
ISO EXP
protein:decreased expression:serum:
CTD PMID:23499715 PMID:23262585 PMID:25359298 PMID:23262585 RGD:10401916 , RGD:10401921 , RGD:10401916
NCBI chr19:48,755,524...48,758,330
G
FLT1
fms related receptor tyrosine kinase 1
ISO
mRNA:decreased expression:heart
RGD
PMID:16741021 PMID:16816123 RGD:2313724 , RGD:2313725
NCBI chr13:28,300,346...28,495,128
G
FN1
fibronectin 1
treatment
ISO
protein:increased expression:kidney
RGD
PMID:22937115 PMID:22228707 RGD:7206838 , RGD:7296926
NCBI chr 2:215,360,865...215,436,068
G
FOXA2
forkhead box A2
ISO
mRNA:increased expression:kidney cortex
RGD
PMID:19433262 RGD:2312358
NCBI chr20:22,580,998...22,585,490
G
FOXA3
forkhead box A3
ISO
mRNA:increased expression:liver
RGD
PMID:11018767 RGD:2315085
NCBI chr19:45,864,326...45,873,797
G
FOXO3
forkhead box O3
ISO EXP
protein:increased phosphorylation, increased expression:glomerulus, cytoplasm:
CTD PMID:23090186 PMID:23792339 PMID:17082237 PMID:12683947 PMID:17082237 RGD:10402196 , RGD:10402199 , RGD:10402196
NCBI chr 6:108,559,825...108,684,774
G
FOXP3
forkhead box P3
treatment
ISO
mRNA,protein:increased expression: peripheral blood, spleen, lymphoid node
RGD
PMID:18328191 PMID:32341701 RGD:38599142 , RGD:38599143
NCBI chr X:49,250,438...49,264,710
G
FUCA1
alpha-L-fucosidase 1
ISO
RGD
PMID:3924473 RGD:2315947
NCBI chr 1:23,845,077...23,868,290
G
FURIN
furin, paired basic amino acid cleaving enzyme
disease_progression
ISO
protein:decreased expression:kidney
RGD
PMID:16541018 RGD:1582625
NCBI chr15:90,868,588...90,883,457
G
G6PC1
glucose-6-phosphatase catalytic subunit 1
treatment
ISO
protein:increased activity:liver, kidney
RGD
PMID:16176150 PMID:27366200 RGD:2315960 , RGD:14695533
NCBI chr17:42,900,799...42,914,438
G
G6PD
glucose-6-phosphate dehydrogenase
treatment
ISO
protein:decreased expression:liver
RGD
PMID:19374864 PMID:25116122 PMID:16718375 RGD:2307337 , RGD:10449121 , RGD:2307345
NCBI chr X:154,531,390...154,547,569
G
GABBR1
gamma-aminobutyric acid type B receptor subunit 1
ISO
RGD
PMID:2849069 RGD:2315971
NCBI chr 6:29,602,238...29,633,183
G
GAL
galanin and GMAP prepropeptide
ISO
protein:decreased expression:pancreatic islet
RGD
PMID:11489087 PMID:7505518 RGD:2313740 , RGD:2313742
NCBI chr11:68,684,544...68,691,175
G
GALP
galanin like peptide
ISO
mRNA:increased expression:arcuate nucleus, pars posterior
RGD
PMID:16046316 PMID:15256810 RGD:2313737 , RGD:2313739
NCBI chr19:56,176,008...56,185,775
G
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
treatment
ISO
RGD
PMID:27655796 RGD:13792671
NCBI chr12:6,534,517...6,538,371
G
GATA4
GATA binding protein 4
ISO
protein:increased serine phosphorylation:heart
RGD
PMID:22293779 RGD:7207042
NCBI chr 8:11,676,935...11,760,002
G
GC
GC vitamin D binding protein
ISO
protein:decreased expression:serum
RGD
PMID:3838933 RGD:2315540
NCBI chr 4:71,741,693...71,805,520
G
GCG
glucagon
treatment
ISO
RGD
PMID:18996945 RGD:10402370
NCBI chr 2:162,142,882...162,152,247
G
GCH1
GTP cyclohydrolase 1
treatment
ISO
protein:increased degradation:heart
RGD
PMID:27295516 PMID:18061195 PMID:18596126 RGD:329961323 , RGD:2314434 , RGD:401700392
NCBI chr14:54,842,017...54,902,826
G
GCK
glucokinase
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:16123366
NCBI chr 7:44,143,213...44,189,439
G
GCNT1
glucosaminyl (N-acetyl) transferase 1
ISO
mRNA:increased expression:heart
RGD
PMID:7560067 RGD:632804
NCBI chr 9:76,393,869...76,507,416
G
GFPT1
glutamine--fructose-6-phosphate transaminase 1
ISO
protein:decreased expression:epididymal fat pad, liver, skeletal muscle
RGD PMID:7589852 RGD:2313355
NCBI chr 2:69,319,780...69,387,227
G
GGT1
gamma-glutamyltransferase 1
ISO
protein:increased activity:serum
RGD
PMID:18291430 RGD:2315577
NCBI chr22:24,583,750...24,628,996
G
GH1
growth hormone 1
ISO
protein:decreased expression:serum, pituitary gland
RGD
PMID:2931155 PMID:19370419 RGD:2315682 , RGD:2315655
NCBI chr17:63,917,203...63,918,839
G
GHR
growth hormone receptor
ISO
RGD
PMID:12529387 PMID:7964296 RGD:2307365 , RGD:11567222
NCBI chr 5:42,423,439...42,721,878
G
GHRH
growth hormone releasing hormone
treatment
ISO
RGD
PMID:22393012 RGD:10401241
NCBI chr20:37,251,086...37,261,814
G
GHRHR
growth hormone releasing hormone receptor
ISO
RGD
PMID:18285528 RGD:10401258
NCBI chr 7:30,963,953...30,979,528
G
GHRL
ghrelin and obestatin prepropeptide
disease_progression
ISO
protein:increased expression:plasma
RGD
PMID:18657539 PMID:23965296 RGD:2313750 , RGD:12905048
NCBI chr 3:10,285,666...10,292,947
G
GHSR
growth hormone secretagogue receptor
ISO
mRNA:increased expression:Arcuate nucleus :
RGD
PMID:23965296 RGD:12905048
NCBI chr 3:172,443,291...172,448,456
G
GIP
gastric inhibitory polypeptide
ISO
mRNA:increased expression:retina (rat)
RGD
PMID:12789546 RGD:2312548
NCBI chr17:48,958,554...48,968,596
G
GIPR
gastric inhibitory polypeptide receptor
ISO
mRNA:increased expression:retina (rat)
RGD
PMID:12789546 RGD:2312548
NCBI chr19:45,668,221...45,683,722
G
GJA1
gap junction protein alpha 1
treatment
ISO
protein:increased expression:dermis
RGD
PMID:22455314 PMID:20130277 PMID:22110070 PMID:20609064 RGD:7207269 , RGD:8662383 , RGD:7364887 , RGD:7207415
NCBI chr 6:121,435,646...121,449,727
G
GJA5
gap junction protein alpha 5
treatment
ISO
RGD
PMID:20609064 RGD:7207415
NCBI chr 1:147,756,199...147,773,351
G
GJB2
gap junction protein beta 2
ISO
mRNA,protein:decreased expression:retina:
RGD
PMID:22110070 RGD:7364887
NCBI chr13:20,187,470...20,192,938
G
GJB6
gap junction protein beta 6
ISO
RGD
PMID:21567444 RGD:7364783
NCBI chr13:20,221,962...20,232,319
G
GJD3
gap junction protein delta 3
ISO
protein:decreased expression:retina
RGD
PMID:23385797 RGD:7364769
NCBI chr17:40,360,652...40,364,737
G
GLP1R
glucagon like peptide 1 receptor
ISO
RGD
PMID:10580413 RGD:1624356
NCBI chr 6:39,048,781...39,091,303
G
GLRX
glutaredoxin
ISO
protein:increase activity:retina:
RGD
PMID:17324929 RGD:9686046
NCBI chr 5:95,813,849...95,822,726
G
GLUL
glutamate-ammonia ligase
treatment
ISO
mRNA, protein:decreased expression: retina
RGD
PMID:21770802 PMID:23595285 PMID:25335981 PMID:23284834 PMID:26677078 RGD:401794412 , RGD:401794586 , RGD:401794423 , RGD:401794421 , RGD:401794418
NCBI chr 1:182,378,098...182,391,790
G
GMPS
guanine monophosphate synthase
ISO
protein:increased activity:liver (rat)
RGD
PMID:3043317 RGD:5135485
NCBI chr 3:155,869,430...155,944,020
G
GNAT1
G protein subunit alpha transducin 1
ISO
protein:decreased expression:retina
RGD
PMID:15939031 RGD:1600001
NCBI chr 3:50,191,610...50,197,696
G
GNAT3
G protein subunit alpha transducin 3
ISO
mRNA, protein;increased expression:taste bud
RGD
PMID:18824257 RGD:2302147
NCBI chr 7:80,458,635...80,512,064
G
GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:9452481
NCBI chr10:112,149,865...112,227,677
G
GPD2
glycerol-3-phosphate dehydrogenase 2
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:16123366
NCBI chr 2:156,400,281...156,586,403
G
GPX1
glutathione peroxidase 1
treatment
ISO EXP
protein:increased expression:liver
CTD PMID:16123366 PMID:19229592 PMID:25744399 PMID:15039483 PMID:18387670 RGD:2306606 , RGD:11353782 , RGD:2306161 , RGD:2306607
NCBI chr 3:49,357,176...49,358,353
G
GPX3
glutathione peroxidase 3
treatment
ISO
protein, mRNA:decreased expression:kidney (rat)
RGD
PMID:16651743 PMID:32546886 PMID:23407453 PMID:12753302 RGD:2312631 , RGD:401827917 , RGD:401827857 , RGD:2312629
NCBI chr 5:151,020,591...151,028,988
G
GRIN1
glutamate ionotropic receptor NMDA type subunit 1
treatment
ISO
RGD
PMID:23595285 RGD:401794586
NCBI chr 9:137,139,154...137,168,756
G
GRIN2B
glutamate ionotropic receptor NMDA type subunit 2B
ISO
mRNA, protein:increased expression:cerebellum (rat)
RGD
PMID:20056114 RGD:4107025
NCBI chr12:13,537,337...13,982,134
G
GRK1
G protein-coupled receptor kinase 1
ISO
protein:increased expression:retina
RGD
PMID:15939031 RGD:1600001
NCBI chr13:113,648,199...113,737,736
G
GSK3A
glycogen synthase kinase 3 alpha
treatment
ISO
RGD
PMID:8526919 RGD:10401824
NCBI chr19:42,230,190...42,242,602
G
GSR
glutathione-disulfide reductase
treatment
ISO EXP
protein:decreased activity:plasma:
CTD PMID:20620209 PMID:20187988 PMID:25050809 RGD:7257587 , RGD:10401889
NCBI chr 8:30,678,066...30,727,846
G
GSTA4
glutathione S-transferase alpha 4
ISO
protein:increased expression:pancreas, kidney, liver (rat)
RGD
PMID:14693714 RGD:5687773
NCBI chr 6:52,977,953...52,995,284
G
GUK1
guanylate kinase 1
ISO
protein:decreased expression:retina (rat)
RGD
PMID:17465459 RGD:5147874
NCBI chr 1:228,140,084...228,148,955
G
H6PD
hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase
ISO
RGD
PMID:20923496 RGD:6784507
NCBI chr 1:9,234,774...9,271,337
G
HADH
hydroxyacyl-CoA dehydrogenase
ISO
RGD
PMID:7050060 RGD:2302232
NCBI chr 4:107,989,889...108,035,171
G
HADHA
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
ISO
protein:decreased expression:brain
RGD
PMID:25260493 RGD:10047114
NCBI chr 2:26,190,635...26,244,632
G
HCN1
hyperpolarization activated cyclic nucleotide gated potassium channel 1
ISO
protein:increased expression:neuron:
RGD
PMID:19815055 RGD:9693680
NCBI chr 5:45,254,948...45,696,380
G
HCN2
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
ISO
protein:increased expression:neuron:
RGD
PMID:19815055 RGD:9693680
NCBI chr19:589,881...617,159
G
HCN3
hyperpolarization activated cyclic nucleotide gated potassium channel 3
ISO
protein:increased expression:neuron:
RGD
PMID:19815055 RGD:9693680
NCBI chr 1:155,277,463...155,289,848
G
HDAC1
histone deacetylase 1
ISO
protein:increased activity:renal cortex:
RGD
PMID:19553350 RGD:9590229
NCBI chr 1:32,292,083...32,333,626
G
HDAC2
histone deacetylase 2
ISO
protein:increased activity:renal cortex:
RGD
PMID:19553350 RGD:9590229
NCBI chr 6:113,933,028...113,971,148
G
HDAC4
histone deacetylase 4
ISO
protein:increased activity:renal cortex:
RGD
PMID:19553350 RGD:9590229
NCBI chr 2:239,048,168...239,401,649
G
HGF
hepatocyte growth factor
ISO
protein:increased expression:kidney
RGD
PMID:16297324 RGD:2313568
NCBI chr 7:81,699,010...81,770,047
G
HIF1A
hypoxia inducible factor 1 subunit alpha
ISO
protein:increased expression:sciatic nerve (rat)
RGD
PMID:15663958 RGD:8694461
NCBI chr14:61,695,513...61,748,258
G
HK1
hexokinase 1
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:16123366
NCBI chr10:69,270,000...69,401,882
G
HMBS
hydroxymethylbilane synthase
ISO
protein:decreased activity:liver (rat)
RGD
PMID:6688350 RGD:4144808
NCBI chr11:119,084,881...119,093,549
G
HMGB1
high mobility group box 1
ISO
associated with Endotoxemia;protein:increased expression:serum
RGD
PMID:19959191 PMID:23261684 RGD:2316737 , RGD:10402069
NCBI chr13:30,456,704...30,617,597
G
HMGCL
3-hydroxy-3-methylglutaryl-CoA lyase
ISO
protein:increased activity:liver (rat)
RGD
PMID:5667251 RGD:2326171
NCBI chr 1:23,801,885...23,825,429
G
HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
ISO
RGD
PMID:15111316 RGD:2313760
NCBI chr 5:75,336,529...75,362,116
G
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1
ISO
protein:increased expression:pancreas
RGD
PMID:18452227 RGD:2302233
NCBI chr 5:43,287,470...43,313,412
G
HMGCS2
3-hydroxy-3-methylglutaryl-CoA synthase 2
ISO
protein:increased expression:liver (rat)
RGD
PMID:7902069 RGD:2326135
NCBI chr 1:119,747,996...119,768,932
G
HMOX1
heme oxygenase 1
ISO EXP
CTD Direct Evidence: marker/mechanism|therapeutic
CTD PMID:16123366 PMID:16959961 PMID:18375438 PMID:19804535 PMID:15734859 RGD:1582713
NCBI chr22:35,381,096...35,394,207
G
HNF4A
hepatocyte nuclear factor 4 alpha
ISO
mRNA:decreased expression:kidney, liver
RGD
PMID:18184923 PMID:19179483 RGD:2301838 , RGD:12904769
NCBI chr20:44,355,699...44,434,596
G
HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
ISO
protein:increased expression:urinary bladder (rat)
RGD
PMID:18337374 RGD:9685410
NCBI chr 7:26,189,927...26,200,746
G
HNRNPK
heterogeneous nuclear ribonucleoprotein K
treatment
ISO
RGD
PMID:16837467 RGD:10002795
NCBI chr 9:83,968,083...83,980,615
G
HP
haptoglobin
ISO
protein:increased expression:serum
RGD
PMID:11072799 RGD:1626381
NCBI chr16:72,054,505...72,061,055
G
HPRT1
hypoxanthine phosphoribosyltransferase 1
ISO
protein:decreased activity:liver (rat)
RGD
PMID:3043317 RGD:5135485
NCBI chr X:134,460,165...134,500,668
G
HRAS
HRas proto-oncogene, GTPase
ISO
mRNA, protein:increased expression:retina blood vessel
RGD
PMID:18514235 RGD:2314841
NCBI chr11:532,242...535,576
G
HSD11B1
hydroxysteroid 11-beta dehydrogenase 1
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:14697232
NCBI chr 1:209,686,179...209,734,929
G
HSP90AA1
heat shock protein 90 alpha family class A member 1
ISO
mRNA:decreased expression:brain (rat)
RGD
PMID:21104931 RGD:5686396
NCBI chr14:102,080,742...102,139,749
G
HSPD1
heat shock protein family D (Hsp60) member 1
ISO
RGD
PMID:17280490 RGD:1624229
NCBI chr 2:197,486,584...197,500,274
G
HSPG2
heparan sulfate proteoglycan 2
ISO
mRNA:decreased expression:retina
RGD
PMID:9068943 RGD:1624265
NCBI chr 1:21,822,244...21,937,310
G
HTR2A
5-hydroxytryptamine receptor 2A
ISO
protein:increased expression:lung
RGD
PMID:21521772 RGD:5135278
NCBI chr13:46,831,546...46,898,082
G
IAPP
islet amyloid polypeptide
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:16123366
NCBI chr12:21,354,959...21,379,980
G
ICAM1
intercellular adhesion molecule 1
treatment
ISO EXP
mRNA:increased expression:aorta
CTD
PMID:14871415 PMID:20388520 PMID:24513509 PMID:18093596 PMID:20136425 PMID:18413153 More...
RGD:2306988 , RGD:8547703 , RGD:2306987
NCBI chr19:10,271,120...10,286,615
G
ID1
inhibitor of DNA binding 1
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:16123366
NCBI chr20:31,605,289...31,606,510
G
IDE
insulin degrading enzyme
ISO
protein:decreased expression:cerebral cortex
RGD
PMID:29940507 RGD:13792791
NCBI chr10:92,451,684...92,574,093
G
IFNAR1
interferon alpha and beta receptor subunit 1
ISO
RGD
PMID:27999109 RGD:12910492
NCBI chr21:33,324,395...33,359,864
G
IFNG
interferon gamma
ISO EXP
mRNA:increased expression:pancreas
CTD PMID:21340626 PMID:18789669 PMID:20213480 RGD:2311492 , RGD:5147915
NCBI chr12:68,154,768...68,159,740
G
IGF1
insulin like growth factor 1
ISO EXP
protein:decreased expression:cerebellum, serum
CTD
PMID:24632065 PMID:19382144 PMID:7536658 PMID:22133301 PMID:18676006 PMID:20555424 More...
RGD:2306671 , RGD:152176653 , RGD:10046054 , RGD:2311502 , RGD:4142788
NCBI chr12:102,395,874...102,481,839
G
IGF1R
insulin like growth factor 1 receptor
ISO
protein:decreased phosphorylation:heart
RGD
PMID:20555424 PMID:18676006 RGD:4142788 , RGD:2311502
NCBI chr15:98,648,539...98,964,530
G
IGF2
insulin like growth factor 2
treatment
ISO IDA
protein:increased expression:oviduct
RGD
PMID:18676006 PMID:23364485 PMID:10686593 PMID:17184497 PMID:18724775 RGD:2311502 , RGD:10402565 , RGD:5509973 , RGD:2311513 , RGD:2311511
NCBI chr11:2,129,117...2,149,566
G
IGF2R
insulin like growth factor 2 receptor
ISO
protein:increased expression:oviduct
RGD
PMID:18676006 RGD:2311502
NCBI chr 6:159,969,082...160,111,504
G
IGFBP1
insulin like growth factor binding protein 1
ISO
mRNA:altered expression:kidney
RGD
PMID:7536658 RGD:152176653
NCBI chr 7:45,888,488...45,893,660
G
IGFBP2
insulin like growth factor binding protein 2
ISO
mRNA:altered expression:kidney
RGD
PMID:7536658 RGD:152176653
NCBI chr 2:216,632,828...216,664,436
G
IGFBP3
insulin like growth factor binding protein 3
treatment
ISO
mRNA, protein:increased expression:penis
RGD
PMID:18068478 PMID:7536658 PMID:25582342 PMID:16180585 RGD:2289159 , RGD:152176653 , RGD:12743617 , RGD:2313766
NCBI chr 7:45,912,245...45,921,272
G
IGFBP4
insulin like growth factor binding protein 4
ISO
mRNA:altered expression:kidney
RGD
PMID:7536658 RGD:152176653
NCBI chr17:40,443,450...40,457,725
G
IGFBP5
insulin like growth factor binding protein 5
ISO
mRNA:altered expression:kidney
RGD
PMID:7536658 RGD:152176653
NCBI chr 2:216,672,105...216,695,549
G
IKBKB
inhibitor of nuclear factor kappa B kinase subunit beta
ISO
protein:increased phosphorylation:liver
RGD
PMID:20362663 RGD:7495777
NCBI chr 8:42,271,302...42,332,460
G
IL10
interleukin 10
ISO
protein:increase expression:serum
RGD
PMID:18787467 PMID:18779928 RGD:2308945 , RGD:2308946
NCBI chr 1:206,767,602...206,772,494
G
IL17A
interleukin 17A
ISO
protein:increased expression:gingiva (rat)
RGD
PMID:21826658 RGD:9068940
NCBI chr 6:52,186,375...52,190,638
G
IL1A
interleukin 1 alpha
ISO
protein:increased expression:heart
RGD
PMID:20555424 RGD:4142788
NCBI chr 2:112,773,925...112,784,493
G
IL1B
interleukin 1 beta
ISO EXP
mRNA:increased expression:skeletal muscle
CTD PMID:12123627 PMID:17669395 PMID:23197974 RGD:1626620 , RGD:7175529
NCBI chr 2:112,829,751...112,836,779
G
IL1RN
interleukin 1 receptor antagonist
ISO IMP
human gene in a rat model
RGD
PMID:19545727 PMID:17221214 PMID:8037760 RGD:6907397 , RGD:8551855 , RGD:6907425
NCBI chr 2:113,099,360...113,134,014
G
IL2
interleukin 2
ISO
protein:increased expression:retina
RGD
PMID:20213480 RGD:5147915
NCBI chr 4:122,451,470...122,456,725
G
IL2RA
interleukin 2 receptor subunit alpha
ISO
RGD PMID:18503494 RGD:2311530
NCBI chr10:6,010,689...6,062,367
G
IL4
interleukin 4
treatment
ISO
RGD
PMID:25191525 RGD:10402795
NCBI chr 5:132,673,989...132,682,678
G
IL4R
interleukin 4 receptor
ISO
RGD
PMID:12165974 RGD:4889983
NCBI chr16:27,313,756...27,364,778
G
IL6
interleukin 6
treatment
ISO EXP
protein:increased expression:heart
CTD
PMID:22138235 PMID:20555424 PMID:28085064 PMID:24582317 PMID:18976114 PMID:19328014 More...
RGD:4142788 , RGD:598130069 , RGD:11049554 , RGD:2306984 , RGD:2307252
NCBI chr 7:22,727,200...22,731,998
G
INS-IGF2
INS-IGF2 readthrough
ISO
CTD Direct Evidence: therapeutic
CTD PMID:2975197 PMID:3044883
NCBI chr11:2,129,117...2,161,209
G
INSIG1
insulin induced gene 1
ISO
RGD
PMID:16327801 RGD:2308858
NCBI chr 7:155,297,878...155,310,235
G
INSR
insulin receptor
disease_progression
ISO EXP IMP
protein:decreased expression:kidney
CTD
PMID:9243097 PMID:22138235 PMID:17855644 PMID:1280238 PMID:2180315 PMID:23874448 PMID:18638371 PMID:18376071 PMID:18430054 More...
RGD:2290475 , RGD:15036814 , RGD:14981592 , RGD:10403045 , RGD:2307025 , RGD:2307339 , RGD:2307338
NCBI chr19:7,112,265...7,294,414
G
IRS1
insulin receptor substrate 1
treatment
ISO EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:22138235 PMID:22983684 PMID:22820932 RGD:7207061 , RGD:7207063
NCBI chr 2:226,731,312...226,799,820
G
IRS2
insulin receptor substrate 2
ISO EXP
protein:decreased phosphorylation:heart
CTD PMID:25808216 PMID:20555424 RGD:4142788
NCBI chr13:109,752,695...109,786,583
G
ISG15
ISG15 ubiquitin like modifier
ISO
RGD
PMID:20973890 RGD:5490977
NCBI chr 1:1,013,497...1,014,540
G
ITGA3
integrin subunit alpha 3
ISO
protein:decreased expression:renal cortex (rat)
RGD
PMID:20525748 RGD:2325818
NCBI chr17:50,056,110...50,090,481
G
ITGAM
integrin subunit alpha M
ISO
protein:increased expression:neutrophil (rat)
RGD
PMID:10752954 RGD:329902069
NCBI chr16:31,259,975...31,332,877
G
ITGB1
integrin subunit beta 1
ISO
protein:decreased expression:epidermal stem cell (rat)
RGD
PMID:20187441 RGD:2325322
NCBI chr10:32,900,318...32,958,230
G
ITGB3
integrin subunit beta 3
ISO
protein:increased expression:aorta:
RGD
PMID:12606526 RGD:8693385
NCBI chr17:47,253,827...47,313,743
G
JAK3
Janus kinase 3
ISO
protein:increased expression:retina
RGD
PMID:21575160 RGD:11533943
NCBI chr19:17,824,782...17,847,982
G
KCNA2
potassium voltage-gated channel subfamily A member 2
ISO
RGD
PMID:17982915 RGD:7242761
NCBI chr 1:110,593,580...110,631,440
G
KCNA5
potassium voltage-gated channel subfamily A member 5
ISO
RGD
PMID:17982915 RGD:7242761
NCBI chr12:5,043,879...5,046,788
G
KCNE2
potassium voltage-gated channel subfamily E regulatory subunit 2
ISO
mRNA:decreased expression:left heart ventricle
RGD
PMID:19267230 RGD:7243942
NCBI chr21:34,364,006...34,371,381
G
KCNJ11
potassium inwardly rectifying channel subfamily J member 11
ISO EXP
protein:decreased expression:brain
CTD PMID:16123366 PMID:23785408 RGD:7296920
NCBI chr11:17,385,248...17,389,346
G
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
ISO
mRNA, protein:decreased expression:aorta, smooth muscle
RGD
PMID:24589593 RGD:10412030
NCBI chr10:76,869,602...77,637,808
G
KCNMB1
potassium calcium-activated channel subfamily M regulatory beta subunit 1
ISO
protein:decreased expression:aorta, smooth muscle
RGD
PMID:24589593 RGD:10412030
NCBI chr 5:170,374,671...170,389,367
G
KCNN4
potassium calcium-activated channel subfamily N member 4
ameliorates
ISO
mRNA, protein:increased expression:aorta, smooth muscle
RGD
PMID:24589593 PMID:29167619 RGD:10412030 , RGD:401784495
NCBI chr19:43,766,533...43,780,973
G
KDM6A
lysine demethylase 6A
ISO
RGD
PMID:31266808 RGD:151665138
NCBI chr X:44,873,188...45,112,779
G
KDR
kinase insert domain receptor
ISO
mRNA:decreased expression:heart
RGD
PMID:16741021 PMID:22121831 PMID:16816123 RGD:2313724 , RGD:5684538 , RGD:2313725
NCBI chr 4:55,078,481...55,125,595
G
KHK
ketohexokinase
ISO
RGD
PMID:6088170 RGD:2302253
NCBI chr 2:27,086,772...27,100,762
G
KIF1A
kinesin family member 1A
ISO
mRNA:increased expression:hippocampus
RGD
PMID:23776493 RGD:11059542
NCBI chr 2:240,713,767...240,821,403
G
KIF5B
kinesin family member 5B
ISO
mRNA:increased expression:hippocampus
RGD
PMID:23776493 RGD:11059542
NCBI chr10:32,009,015...32,056,425
G
KIT
KIT proto-oncogene, receptor tyrosine kinase
ISO
protein:increased expression:pancreas
RGD
PMID:17235568 RGD:2311225
NCBI chr 4:54,657,957...54,740,715
G
KLK1
kallikrein 1
ISO
mRNA:decreased expression:myocardium
RGD
PMID:10604522 RGD:1641812
NCBI chr19:50,819,146...50,823,787
G
KMT5C
lysine methyltransferase 5C
ISO
mRNA:increased expression:retina
RGD
PMID:21357467 RGD:9586742
NCBI chr19:55,339,876...55,348,121
G
LCN2
lipocalin 2
ISO
mRNA:increased expression:retina (rat)
RGD
PMID:15623795 PMID:23085980 RGD:2316515 , RGD:7245484
NCBI chr 9:128,149,453...128,153,453
G
LCT
lactase
ISO
RGD PMID:16021836 RGD:1600251
NCBI chr 2:135,787,850...135,837,184
G
LDLR
low density lipoprotein receptor
ISO
mRNA:decreased expression:liver
RGD
PMID:18054320 RGD:2324626
NCBI chr19:11,089,463...11,133,820
G
LEP
leptin
onset
ISO EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:28242381 PMID:31313498 PMID:31483951 PMID:19491210 PMID:20695765 PMID:19428774 More...
RGD:2311124 , RGD:5128579 , RGD:2311126
NCBI chr 7:128,241,278...128,257,629
G
LEPR
leptin receptor
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:15093691 PMID:16427799 PMID:17065336 PMID:19452630 PMID:19478208 PMID:20567778 PMID:22933112 PMID:24263156 PMID:26939912 PMID:27151219 PMID:30635400 PMID:35472412 PMID:36066211 PMID:39059604 More...
NCBI chr 1:65,420,652...65,641,559
G
LGALS3
galectin 3
treatment
ISO
RGD
PMID:21249158 RGD:9685210
NCBI chr14:55,129,252...55,145,430
G
LIPC
lipase C, hepatic type
ISO
protein:decreased activity:liver (rat)
RGD
PMID:18758746 PMID:1868959 RGD:2307432 , RGD:2308849
NCBI chr15:58,431,991...58,569,844
G
LITAF
lipopolysaccharide induced TNF factor
ISO
protein:increased expression:retina
RGD
PMID:21575160 RGD:11533943
NCBI chr16:11,547,722...11,640,317
G
LPIN1
lipin 1
ISO
mRNA:increased expression:skeletal muscle
RGD
PMID:14718385 RGD:1641826
NCBI chr 2:11,677,544...11,827,409
G
LPL
lipoprotein lipase
treatment
ISO
RGD
PMID:18780778 PMID:27158912 RGD:2313303 , RGD:13794379
NCBI chr 8:19,939,253...19,967,259
G
LRP2
LDL receptor related protein 2
ISO
protein:decreased expression:kidney, proximal convoluted tubule, apical plasma membrane
RGD
PMID:11685557 RGD:1641843
NCBI chr 2:169,127,109...169,362,534
G
LTBP1
latent transforming growth factor beta binding protein 1
ISO
RGD
PMID:17574405 RGD:2302087
NCBI chr 2:32,946,953...33,399,509
G
MAFA
MAF bZIP transcription factor A
treatment
ISO
RGD
PMID:28487936 RGD:13506743
NCBI chr 8:143,428,064...143,430,732
G
MAP2K3
mitogen-activated protein kinase kinase 3
ISO
mRNA:increased expression:kidney, glomerulus
RGD
PMID:11473637 RGD:7495813
NCBI chr17:21,284,711...21,315,240
G
MAP2K6
mitogen-activated protein kinase kinase 6
ISO
mRNA:increased expression:kidney, glomerulus
RGD
PMID:11473637 RGD:7495813
NCBI chr17:69,414,697...69,553,865
G
MAP3K5
mitogen-activated protein kinase kinase kinase 5
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:18342293
NCBI chr 6:136,557,046...136,793,091
G
MAP3K8
mitogen-activated protein kinase kinase kinase 8
ISO
protein:increased activity:serum:
RGD
PMID:28724746 RGD:151356966
NCBI chr10:30,434,021...30,461,833
G
MAPK1
mitogen-activated protein kinase 1
ISO
protein:decreased phosphorylation:cornea
RGD
PMID:22045654 PMID:21330660 RGD:7243969 , RGD:5131482
NCBI chr22:21,759,657...21,867,680
G
MAPK3
mitogen-activated protein kinase 3
ISO
protein:decreased phosphorylation:cornea
RGD
PMID:21330660 RGD:5131482
NCBI chr16:30,114,105...30,123,220
G
MAPT
microtubule associated protein tau
treatment
ISO
RGD
PMID:28400135 RGD:13800903
NCBI chr17:45,894,554...46,028,334
G
MAS1
MAS1 proto-oncogene, G protein-coupled receptor
ISO
mRNA:increased expression:renal cortex (rat)
RGD
PMID:18679036 RGD:2313799
NCBI chr 6:159,888,787...159,917,447
G
MBP
myelin basic protein
ISO
RGD
PMID:23667870 RGD:7327197
NCBI chr18:76,978,833...77,133,708
G
MDM2
MDM2 proto-oncogene
ISO
protein:increased degradation:myocardium
RGD
PMID:23530877 RGD:10412313
NCBI chr12:68,808,172...68,850,686
G
MEF2A
myocyte enhancer factor 2A
ISO
mRNA:increased expression:heart
RGD
PMID:18413674 RGD:2312263
NCBI chr15:99,565,417...99,716,488
G
MEF2C
myocyte enhancer factor 2C
ISO
mRNA:increased expression:heart
RGD
PMID:18413674 RGD:2312263
NCBI chr 5:88,717,117...88,904,105
G
MET
MET proto-oncogene, receptor tyrosine kinase
ISO
mRNA, protein:increased expression:kidney, tubule, epithelium (rat)
RGD
PMID:8997394 RGD:2317555
NCBI chr 7:116,672,196...116,798,377
G
MFGE8
milk fat globule EGF and factor V/VIII domain containing
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:21505870
NCBI chr15:88,898,683...88,913,379
G
MFN2
mitofusin 2
treatment
ISO
protein:increased expression:heart, mitochondrion (rat)
RGD
PMID:28483572 PMID:27998959 RGD:12910731 , RGD:12910739
NCBI chr 1:11,980,444...12,013,508
G
MIF
macrophage migration inhibitory factor
ISO
protein:increased expression:pancreatic islet
RGD
PMID:15790730 RGD:1641951
NCBI chr22:23,894,383...23,895,223
G
MMP1
matrix metallopeptidase 1
ISO
protein:increased expression:periodontal ligament, alveolar bone of mandible (rat)
RGD
PMID:20082587 RGD:7207377
NCBI chr11:102,789,919...102,798,160
G
MMP2
matrix metallopeptidase 2
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:21963884
NCBI chr16:55,478,830...55,506,691
G
MMP9
matrix metallopeptidase 9
treatment
ISO EXP
protein:increased expression:kidney
CTD PMID:21963884 PMID:22191573 PMID:17569353 PMID:23089644 PMID:23423566 RGD:2290354 , RGD:8547974 , RGD:8547881
NCBI chr20:46,008,908...46,016,561
G
MPO
myeloperoxidase
ISO EXP
protein:increased activity:liver:
CTD PMID:20388520 PMID:18436980 RGD:2317971
NCBI chr17:58,269,855...58,280,935
G
MT-CO2
mitochondrially encoded cytochrome c oxidase II
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:14563825
NCBI chr MT:7,586...8,269
G
MT-CYB
mitochondrially encoded cytochrome b
ISO
mRNA:decreased expression:heart
RGD
PMID:15126286 RGD:1578536
NCBI chr MT:14,747...15,887
G
MT-ND1
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:14563825
NCBI chr MT:3,307...4,262
G
MTHFR
methylenetetrahydrofolate reductase
ISO
protein:decreased activity:kidney (rat)
RGD
PMID:9836532 RGD:6893689
NCBI chr 1:11,785,723...11,805,964
G
MTOR
mechanistic target of rapamycin kinase
ISO
protein:hyperphosphorylation:muscle
RGD
PMID:28536139 RGD:13506787
NCBI chr 1:11,106,535...11,262,551
G
MTR
5-methyltetrahydrofolate-homocysteine methyltransferase
ISO
protein:decreased activity:liver
RGD
PMID:18936199 RGD:7207081
NCBI chr 1:236,795,281...236,903,981
G
MYC
MYC proto-oncogene, bHLH transcription factor
ISO
mRNA:increased expression:renal cortex (rat)
RGD
PMID:18030501 RGD:7207459
NCBI chr 8:127,735,434...127,742,951
G
NAMPT
nicotinamide phosphoribosyltransferase
ISO
protein:decreased expression:fat cell
RGD
PMID:18410550 RGD:2311099
NCBI chr 7:106,248,298...106,285,888
G
NCF1
neutrophil cytosolic factor 1
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:14871415 PMID:16380483
NCBI chr 7:74,774,011...74,789,315
G
NCF2
neutrophil cytosolic factor 2
ISO
protein:increased expression:heart, membrane fraction
RGD
PMID:18061195 PMID:14514646 RGD:2314434 , RGD:2314451
NCBI chr 1:183,555,562...183,601,849
G
NDUFS2
NADH:ubiquinone oxidoreductase core subunit S2
ISO
protein:decreased expression:dorsal root ganglia (rat)
RGD
PMID:20876714 RGD:6484699
NCBI chr 1:161,197,417...161,214,395
G
NDUFS3
NADH:ubiquinone oxidoreductase core subunit S3
ISO
protein:decreased expression:dorsal root ganglia (rat)
RGD
PMID:20876714 PMID:22387129 RGD:6484699 , RGD:13824971
NCBI chr11:47,579,074...47,584,562
G
NEFH
neurofilament heavy chain
treatment
ISO
RGD
PMID:12941778 RGD:9698428
NCBI chr22:29,480,218...29,491,390
G
NEFM
neurofilament medium chain
treatment
ISO
RGD
PMID:12941778 RGD:9698428
NCBI chr 8:24,913,761...24,919,093
G
NEUROD1
neuronal differentiation 1
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:16123366
NCBI chr 2:181,668,295...181,680,517
G
NEUROG3
neurogenin 3
ISO
RGD
PMID:19819964 RGD:2313774
NCBI chr10:69,571,485...69,573,422
G
NFE2L2
NFE2 like bZIP transcription factor 2
treatment
ISO
protein:increased localization:blood, mononuclear cell, nucleus
RGD
PMID:22869588 PMID:23331247 PMID:24740568 RGD:10412694 , RGD:7244270 , RGD:10412720
NCBI chr 2:177,230,303...177,264,727
G
NFKB2
nuclear factor kappa B subunit 2
ISO
RGD
PMID:18633731 RGD:2298775
NCBI chr10:102,394,110...102,402,529
G
NFKBIA
NFKB inhibitor alpha
treatment
ISO
protein:decreased expression:kidney
RGD
PMID:22483164 PMID:20188823 RGD:10413864 , RGD:10413873
NCBI chr14:35,401,513...35,404,749
G
NGF
nerve growth factor
treatment
ISO
mRNA, protein:decreased expression:sciatic nerve
RGD
PMID:19149268 PMID:25728260 PMID:26282349 PMID:21136036 RGD:2303795 , RGD:402463972 , RGD:402463971 , RGD:5144144
NCBI chr 1:115,285,917...115,338,249
G
NGFR
nerve growth factor receptor
ISO
protein:increased expression:retina
RGD
PMID:21136036 PMID:26282349 RGD:5144144 , RGD:402463971
NCBI chr17:49,495,293...49,515,008
G
NKX6-1
NK6 homeobox 1
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:16123366
NCBI chr 4:84,491,985...84,499,292
G
NOS1
nitric oxide synthase 1
ISO
protein:decreased dimerization:stomach
RGD
PMID:17347455 RGD:1642144
NCBI chr12:117,208,142...117,361,626
G
NOS2
nitric oxide synthase 2
no_association
ISO EXP
associated with Infarction, Middle Cerebral Artery; protein:increased expression:brain (rat)
CTD PMID:16380483 PMID:16959961 PMID:21993016 PMID:9349594 RGD:5509105 , RGD:5509107
NCBI chr17:27,756,766...27,800,529
G
NOS3
nitric oxide synthase 3
treatment
ISO EXP
protein:increased expression:heart
CTD
PMID:11696579 PMID:14871415 PMID:15490108 PMID:16959961 PMID:18266981 PMID:19478208 PMID:22191573 PMID:22933112 PMID:18287592 PMID:28976888 PMID:21050844 PMID:21050844 PMID:18825362 More...
RGD:2292100 , RGD:13450939 , RGD:7777108 , RGD:7777108 , RGD:4892007
NCBI chr 7:150,991,017...151,014,588
G
NOX4
NADPH oxidase 4
ISO
protein:increased expression:aorta
RGD
PMID:19686728 RGD:2324658
NCBI chr11:89,324,353...89,589,557
G
NPC1L1
NPC1 like intracellular cholesterol transporter 1
ISO
mRNA:increased expression:intestine, liver
RGD
PMID:17292734 RGD:1642185
NCBI chr 7:44,512,535...44,541,330
G
NPPA
natriuretic peptide A
ISO
protein:decreased expression:retina
RGD
PMID:15789000 PMID:17151304 RGD:1580773 , RGD:7248602
NCBI chr 1:11,845,709...11,847,783
G
NPPB
natriuretic peptide B
ISO
protein:increased expression:atrium myocardium, plasma
RGD
PMID:17151299 RGD:1642199
NCBI chr 1:11,857,464...11,858,945
G
NPY
neuropeptide Y
ISO
protein:increased expression:paraventricular nucleus of hypothalamus
RGD
PMID:21042571 RGD:10448960
NCBI chr 7:24,284,190...24,291,862
G
NPY1R
neuropeptide Y receptor Y1
ISO
RGD
PMID:18201831 RGD:10448967
NCBI chr 4:163,323,962...163,344,689
G
NPY2R
neuropeptide Y receptor Y2
ISO
RGD
PMID:18201831 RGD:10448967
NCBI chr 4:155,173,723...155,217,076
G
NQO1
NAD(P)H quinone dehydrogenase 1
EXP
CTD Direct Evidence: therapeutic
CTD PMID:23458895
NCBI chr16:69,709,401...69,726,560
G
NR1H3
nuclear receptor subfamily 1 group H member 3
ISO
DNA, mRNA, protein:hypomethylation, increased expression:promoter, heart
RGD
PMID:21136146 RGD:13831298
NCBI chr11:47,248,300...47,269,033
G
NR1H4
nuclear receptor subfamily 1 group H member 4
ISO
mRNA:decreased expression:liver
RGD
PMID:15047603 RGD:1625080
NCBI chr12:100,473,866...100,564,414
G
NR1I3
nuclear receptor subfamily 1 group I member 3
treatment
ISO
RGD
PMID:20636876 RGD:9835393
NCBI chr 1:161,229,669...161,238,203
G
NR3C1
nuclear receptor subfamily 3 group C member 1
treatment
ISO
protein:increased expression:placenta
RGD
PMID:21744335 PMID:26883980 RGD:12879479 , RGD:14695543
NCBI chr 5:143,277,931...143,435,512
G
NRP1
neuropilin 1
ISO
mRNA:decreased expression:skeletal muscle
RGD
PMID:16816123 RGD:2313725
NCBI chr10:33,177,493...33,334,667
G
NT5E
5'-nucleotidase ecto
ISO
protein:increased expression:cerebral cortex, synaptosome (rat)
RGD
PMID:19723569 RGD:5134343
NCBI chr 6:85,450,083...85,495,784
G
NTRK1
neurotrophic receptor tyrosine kinase 1
ISO
protein:increased tyrosine nitration, decreased tyrosine phosphorylation:retina
RGD
PMID:21136036 PMID:22044876 RGD:5144144 , RGD:5684337
NCBI chr 1:156,815,750...156,881,850
G
NTRK2
neurotrophic receptor tyrosine kinase 2
treatment
ISO
RGD
PMID:30816461 RGD:596936233
NCBI chr 9:84,668,522...85,027,054
G
NTRK3
neurotrophic receptor tyrosine kinase 3
ISO
mRNA:decreased expression:dorsal root ganglion
RGD
PMID:9541170 RGD:2325654
NCBI chr15:87,859,751...88,256,739
G
OGG1
8-oxoguanine DNA glycosylase
ISO
protein:altered localization:pancreatic islet
RGD
PMID:18676009 PMID:18599524 PMID:15677345 RGD:2317137 , RGD:8657153 , RGD:8657146
NCBI chr 3:9,749,952...9,783,108
G
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
treatment
ISO
RGD
PMID:15561949 RGD:9590198
NCBI chr X:71,533,104...71,575,892
G
OPRK1
opioid receptor kappa 1
ISO
protein:increased expression:sciatic nerve, peroneal nerve:
RGD
PMID:16924480 RGD:9834947
NCBI chr 8:53,225,724...53,251,637
G
OPRM1
opioid receptor mu 1
ISO
RGD
PMID:16901587 RGD:2316626
NCBI chr 6:154,010,496...154,246,867
G
OSBP
oxysterol binding protein
ISO
protein:increased tyrosine phosphorylation:aorta
RGD
PMID:18230613 RGD:2291921
NCBI chr11:59,574,398...59,615,774
G
OTC
ornithine transcarbamylase
ISO
protein:decreased activity:small intestine (rat)
RGD
PMID:9628242 RGD:4144123
NCBI chr X:38,327,684...38,422,928
G
OXCT1
3-oxoacid CoA-transferase 1
ISO
protein:decreased activity:heart, mitochondrion (rat)
RGD
PMID:3548709 RGD:2326100
NCBI chr 5:41,730,065...41,870,425
G
PARP1
poly(ADP-ribose) polymerase 1
ISO
RGD
PMID:18657544 RGD:2312287
NCBI chr 1:226,360,691...226,408,093
G
PAX6
paired box 6
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:16123366
NCBI chr11:31,789,026...31,817,961
G
PC
pyruvate carboxylase
ISO
CTD Direct Evidence: marker/mechanism
CTD PMID:16123366
NCBI chr11:66,848,420...66,958,383
G
PCK1
phosphoenolpyruvate carboxykinase 1
ISO EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:20363216 PMID:17651728 RGD:2311641
NCBI chr20:57,561,110...57,568,121
G
PCSK1
proprotein convertase subtilisin/kexin type 1
ISO
mRNA, protein:increased expression:spleen (mouse)
RGD
PMID:11730986 PMID:17698597 PMID:11730986 RGD:2308905 , RGD:2308931 , RGD:2308905
NCBI chr 5:96,390,333...96,433,248
G
PCSK2
proprotein convertase subtilisin/kexin type 2
ISO EXP
mRNA:increased expression:spleen
CTD PMID:16123366 PMID:11730986 RGD:2308905
NCBI chr20:17,226,107...17,484,578
G
PDE3A
phosphodiesterase 3A
ISO
mRNA, protein:increased expression:mesenteric artery
RGD
PMID:12793980 RGD:2300416
NCBI chr12:20,368,537...20,688,583
G
PDE5A
phosphodiesterase 5A
ISO
RGD
PMID:19542492 RGD:2314461
NCBI chr 4:119,494,403...119,628,804
G
PDGFB
platelet derived growth factor subunit B
ISO
mRNA:increased expression:retina
RGD
PMID:12606528 PMID:9763208 PMID:21367419 PMID:8094359 PMID:14685146 RGD:1581759 , RGD:10449499 , RGD:6483042 , RGD:2311650 , RGD:2311648
NCBI chr22:39,223,359...39,244,982
G
PDGFRB
platelet derived growth factor receptor beta
ISO
protein:increased expression:glomerulus
RGD
PMID:10802145 RGD:2311654
NCBI chr 5:150,113,839...150,155,845
G
PDK4
pyruvate dehydrogenase kinase 4
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:14563825
NCBI chr 7:95,583,499...95,596,516
G
PDP2
pyruvate dehydrogenase phosphatase catalytic subunit 2
ISO
RGD
PMID:12765946 RGD:1582364
NCBI chr16:66,880,515...66,891,101
G
PDX1
pancreatic and duodenal homeobox 1
ISO EXP IMP
CTD Direct Evidence: marker/mechanism
CTD
PMID:16123366 PMID:17460716 PMID:15561947 PMID:14988244 PMID:17235568 PMID:17226789 More...
RGD:2311224 , RGD:2311226 , RGD:1357906 , RGD:2311225 , RGD:2311311
NCBI chr13:27,920,000...27,926,313
G
PDYN
prodynorphin
ISO
protein:increased expression:sciatic nerve, peroneal nerve, tibial nerve, footpad skin:
RGD
PMID:16924480 RGD:9834947
NCBI chr20:1,978,756...1,994,285
G
PECAM1
platelet and endothelial cell adhesion molecule 1
ISO
protein:decreased expression:corpus callosum, endothelium (rat)
RGD
PMID:21967314 RGD:6771179
NCBI chr17:64,319,415...64,390,860
G
PEMT
phosphatidylethanolamine N-methyltransferase
ISO
protein:increased expression:liver
RGD
PMID:17116711 RGD:1642370
NCBI chr17:17,505,563...17,592,142
G
PFAS
phosphoribosylformylglycinamidine synthase
ISO
protein:increased activity:liver (rat)
RGD
PMID:3043317 RGD:5135485
NCBI chr17:8,247,608...8,270,486
G
PFKM
phosphofructokinase, muscle
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:14563825
NCBI chr12:48,105,353...48,146,404
G
PGF
placental growth factor
ISO
mRNA, protein:decreased expression:placenta, trophoblast cell
RGD
PMID:17917370 RGD:6483782
NCBI chr14:74,941,830...74,955,764
G
PHKA1
phosphorylase kinase regulatory subunit alpha 1
ISO
RGD
PMID:11692172 RGD:1599897
NCBI chr X:72,578,814...72,714,306
G
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
ISO
protein:increased expression:gastrocnemius (rat)
RGD
PMID:18430054 RGD:2307338
NCBI chr 5:68,215,756...68,301,821
G
PKLR
pyruvate kinase L/R
ISO EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:20363216 PMID:16900249 RGD:1625589
NCBI chr 1:155,289,293...155,308,654
G
PLCB3
phospholipase C beta 3
ISO
protein:decreased expression:heart left ventricle
RGD
PMID:15362504 RGD:2314509
NCBI chr11:64,251,530...64,269,452
G
PLCG1
phospholipase C gamma 1
ISO
protein:increased tyrosine phosphorylation:lens
RGD
PMID:17612968 RGD:2299877
NCBI chr20:41,137,543...41,177,626
G
PNMT
phenylethanolamine N-methyltransferase
ISO
protein:increased expression:adrenal gland (rat)
RGD
PMID:16396986 RGD:5130724
NCBI chr17:39,668,019...39,670,475
G
POLG
DNA polymerase gamma, catalytic subunit
ISO
mRNA,protein:decreased expression:retina,mitochondrion:
RGD
PMID:22743328 PMID:22229649 RGD:8694093 , RGD:8694187
NCBI chr15:89,316,320...89,334,824
G
POLG2
DNA polymerase gamma 2, accessory subunit
ISO
mRNA,protein:decreased expression:retina,mitochondrion:
RGD
PMID:22229649 RGD:8694187
NCBI chr17:64,477,785...64,497,054
G
PON1
paraoxonase 1
ISO IMP
RGD
PMID:18358245 PMID:18358245 RGD:2313268 , RGD:2313268
NCBI chr 7:95,297,676...95,324,532
G
PPARA
peroxisome proliferator activated receptor alpha
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:12967931 PMID:14563825 PMID:23090186
NCBI chr22:46,150,526...46,243,756
G
PPARD
peroxisome proliferator activated receptor delta
ISO
mRNA, protein:decreased expression:heart
RGD
PMID:18573863 RGD:2313781
NCBI chr 6:35,342,558...35,428,178
G
PPARG
peroxisome proliferator activated receptor gamma
ISO EXP
mRNA:altered expression:aorta, kidney cortex, retina
CTD PMID:12967931 PMID:16123366 PMID:21757225 PMID:18641696 PMID:18806296 RGD:2301849 , RGD:2301844
NCBI chr 3:12,287,368...12,434,344
G
PPARGC1A
PPARG coactivator 1 alpha
treatment
ISO EXP
mRNA:decreased expression:pancreatic islet
CTD PMID:14563825 PMID:18270681 PMID:19520786 PMID:22561641 PMID:23272147 RGD:2311391 , RGD:2311445 , RGD:7242175 , RGD:7241845
NCBI chr 4:23,792,021...24,472,905
G
PPAT
phosphoribosyl pyrophosphate amidotransferase
ISO
protein:increased activity:kidney (rat)
RGD
PMID:2451505 RGD:5135016
NCBI chr 4:56,393,362...56,435,615
G
PRKAA2
protein kinase AMP-activated catalytic subunit alpha 2
treatment
ISO
RGD
PMID:32535406 RGD:401850547
NCBI chr 1:56,645,314...56,715,335
G
PRKCA
protein kinase C alpha
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:12198386
NCBI chr17:66,302,613...66,810,743
G
PRKCB
protein kinase C beta
ISO
protein:increased expression:myocardium
RGD
PMID:17250813 RGD:1625511
NCBI chr16:23,835,983...24,220,611
G
PRKCD
protein kinase C delta
ISO EXP
protein:increased expression:kidney
CTD PMID:12198386 PMID:11576956 RGD:1642532
NCBI chr 3:53,161,209...53,192,717
G
PRKCE
protein kinase C epsilon
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:12198386
NCBI chr 2:45,651,279...46,187,990
G
PRKCI
protein kinase C iota
ISO
protein:increased expression:ventricle myocardium, membrane fraction
RGD
PMID:14691046 RGD:2314944
NCBI chr 3:170,222,424...170,305,977
G
PRKG1
protein kinase cGMP-dependent 1
treatment
ISO
protein:decreased expression:aorta
RGD
PMID:20186099 PMID:15939056 RGD:7775064 , RGD:7777110
NCBI chr10:50,990,888...52,298,350
G
PRKRA
protein activator of interferon induced protein kinase EIF2AK2
ISO
RGD
PMID:21897745 RGD:7777145
NCBI chr 2:178,431,414...178,451,175
G
PSMB9
proteasome 20S subunit beta 9
ISO
mRNA:increased expression:hippocampus (rat)
RGD
PMID:20968039 RGD:9850284
NCBI chr 6:32,854,192...32,859,851
G
PTGIS
prostaglandin I2 synthase
treatment
ISO
RGD
PMID:8888351 RGD:401960094
NCBI chr20:49,503,874...49,568,137
G
PTGS1
prostaglandin-endoperoxide synthase 1
ISO
protein:decreased expression:spinal cord
RGD
PMID:12086957 RGD:727386
NCBI chr 9:122,370,533...122,395,703
G
PTGS2
prostaglandin-endoperoxide synthase 2
ISO EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:14514642 PMID:21414306 PMID:18706904 PMID:21521772 PMID:17720896 RGD:2300222 , RGD:5135278 , RGD:1642588
NCBI chr 1:186,671,791...186,680,423
G
PTPN1
protein tyrosine phosphatase non-receptor type 1
ISO
protein:increased activity:retina (mouse)
RGD
PMID:19029027 RGD:401965415
NCBI chr20:50,510,383...50,585,241
G
PTPRN
protein tyrosine phosphatase receptor type N
severity
ISO
RGD
PMID:19513530 RGD:2313594
NCBI chr 2:219,289,623...219,309,401
G
PTPRU
protein tyrosine phosphatase receptor type U
ISO
protein:decreased expression:glomerulus
RGD
PMID:16539708 RGD:1642656
NCBI chr 1:29,236,522...29,326,800
G
PYGM
glycogen phosphorylase, muscle associated
ISO
protein:increased expression:sarcoplasmic reticulum
RGD
PMID:11692172 RGD:1599897
NCBI chr11:64,746,389...64,760,715
G
QDPR
quinoid dihydropteridine reductase
ISO
protein:decreased activity:brain (rat)
RGD
PMID:2758679 RGD:5128601
NCBI chr 4:17,486,395...17,512,090
G
RAMP2
receptor activity modifying protein 2
ISO
mRNA:increased expression:kidney
RGD
PMID:14717924 RGD:1642701
NCBI chr17:42,761,227...42,763,041
G
RAP1B
RAP1B, member of RAS oncogene family
ISO
protein:increased expression:renal glomerulus (rat)
RGD
PMID:12196513 RGD:10041023
NCBI chr12:68,610,899...68,671,901
G
RASGRF1
Ras protein specific guanine nucleotide releasing factor 1
ISO
protein:decreased expression:brain, membrane (rat)
RGD
PMID:19002579 RGD:10003129
NCBI chr15:78,959,906...79,090,780
G
RBFOX2
RNA binding fox-1 homolog 2
ISO
mRNA:splice variant: heart (mouse)
RGD
PMID:27239029 PMID:24151077 RGD:329845874 , RGD:329848997
NCBI chr22:35,738,736...36,028,824
G
REG1A
regenerating family member 1 alpha
treatment
ISO
protein:increased expression:pancreas, islet cell (rat)
RGD
PMID:8170952 PMID:8574288 RGD:9850123 , RGD:9850143
NCBI chr 2:79,120,488...79,123,409
G
REG3A
regenerating family member 3 alpha
susceptibility
ISO
RGD
PMID:21245462 RGD:9831432
NCBI chr 2:79,157,006...79,159,753
G
RELA
RELA proto-oncogene, NF-kB subunit
ISO EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:22138235 PMID:18633731 PMID:18500427 RGD:2298775 , RGD:2298780
NCBI chr11:65,653,601...65,663,857
G
REN
renin
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:18829990
NCBI chr 1:204,154,819...204,166,337
G
RGN
regucalcin
ISO
protein:decreased expression:liver
RGD
PMID:9062895 RGD:9590177
NCBI chr X:47,078,443...47,093,313
G
RHOA
ras homolog family member A
ISO
RGD PMID:17589825 RGD:1642825
NCBI chr 3:49,359,145...49,411,976
G
RPE65
retinoid isomerohydrolase RPE65
ISO
mRNA:decreased expression:retina (rat)
RGD
PMID:21862641 RGD:9585653
NCBI chr 1:68,428,822...68,449,954
G
RYR2
ryanodine receptor 2
ISO
RGD
PMID:17027851 RGD:1599247
NCBI chr 1:237,042,184...237,833,988
G
S100A6
S100 calcium binding protein A6
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:16123366
NCBI chr 1:153,534,599...153,535,991
G
S100B
S100 calcium binding protein B
ISO
protein:increased expression:cerebellum, cerebral cortex, hippocampus
RGD
PMID:14583344 PMID:18708122 RGD:5508821 , RGD:5508836
NCBI chr21:46,598,604...46,605,082
G
S1PR2
sphingosine-1-phosphate receptor 2
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:22406263
NCBI chr19:10,221,433...10,231,331
G
S1PR4
sphingosine-1-phosphate receptor 4
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:22406263
NCBI chr19:3,178,769...3,180,332
G
S1PR5
sphingosine-1-phosphate receptor 5
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:22406263
NCBI chr19:10,512,742...10,517,965
G
SCAP
SREBF chaperone
ISO
RGD
PMID:20973890 RGD:5490977
NCBI chr 3:47,413,681...47,477,127
G
SCD
stearoyl-CoA desaturase
treatment
ISO
RGD
PMID:32535406 RGD:401850547
NCBI chr10:100,347,233...100,364,826
G
SCP2
sterol carrier protein 2
treatment
ISO
RGD
PMID:7628371 RGD:9850252
NCBI chr 1:52,927,276...53,051,698
G
SELP
selectin P
treatment
ISO
RGD
PMID:18095572 RGD:2312301
NCBI chr 1:169,588,849...169,630,124
G
SERPINC1
serpin family C member 1
treatment
ISO
RGD
PMID:22309505 PMID:24671746 RGD:11035271 , RGD:11035293
NCBI chr 1:173,903,800...173,917,327
G
SERPINE1
serpin family E member 1
ISO EXP
protein:increased expression:heart (mouse)
CTD PMID:21757225 PMID:20630999 RGD:8547862
NCBI chr 7:101,127,104...101,139,247
G
SERPINF1
serpin family F member 1
ISO
protein:decreased expression:platelet
RGD
PMID:19237211 RGD:2312338
NCBI chr17:1,762,060...1,777,565
G
SI
sucrase-isomaltase
ISO
protein:increased expression:small intestine mucosa
RGD
PMID:12940455 RGD:1625543
NCBI chr 3:164,978,898...165,090,232
G
SIRT1
sirtuin 1
treatment
ISO EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:23090186 PMID:23792339 PMID:22179968 RGD:9586012
NCBI chr10:67,884,656...67,918,390
G
SLC1A3
solute carrier family 1 member 3
treatment
ISO
RGD
PMID:23595285 RGD:401794586
NCBI chr 5:36,606,606...36,688,334
G
SLC22A1
solute carrier family 22 member 1
ISO
RGD PMID:14718608 RGD:2317435
NCBI chr 6:160,121,815...160,158,718
G
SLC22A2
solute carrier family 22 member 2
ISO
protein:decreased expression:kidney
RGD
PMID:19356064 RGD:2312728
NCBI chr 6:160,216,755...160,258,821
G
SLC28A2
solute carrier family 28 member 2
ISO
RGD PMID:16014043 RGD:2317455
NCBI chr15:45,252,234...45,277,846
G
SLC28A3
solute carrier family 28 member 3
ISO
RGD PMID:16014043 RGD:2317455
NCBI chr 9:84,275,457...84,368,727
G
SLC29A1
solute carrier family 29 member 1 (Augustine blood group)
ISO
mRNA:decreased expression:cardiac muscle cell
RGD
PMID:16873415 RGD:2316941
NCBI chr 6:44,219,615...44,234,142
G
SLC2A1
solute carrier family 2 member 1
treatment
ISO
mRNA, protein:decreased expression:brain
RGD
PMID:17935675 PMID:8345816 RGD:2313617 , RGD:12879858
NCBI chr 1:42,925,353...42,958,868
G
SLC2A2
solute carrier family 2 member 2
ISO EXP
mRNA:increased expression:kidney
CTD PMID:16123366 PMID:19433262 RGD:2312358
NCBI chr 3:170,996,347...171,026,720
G
SLC2A3
solute carrier family 2 member 3
ISO
mRNA, protein:decreased expression:brain
RGD
PMID:17935675 RGD:2313617
NCBI chr12:7,919,230...7,936,187
G
SLC2A4
solute carrier family 2 member 4
ISO EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:11947963 PMID:14563825 PMID:18266981 PMID:22138235 PMID:19252289 RGD:2313621
NCBI chr17:7,281,718...7,288,257
G
SLC37A4
solute carrier family 37 member 4
ISO
protein:increased expression:liver
RGD
PMID:10567346 RGD:1625641
NCBI chr11:119,024,112...119,030,877
G
SLC38A2
solute carrier family 38 member 2
ISO
RGD
PMID:11798158 RGD:9999213
NCBI chr12:46,358,188...46,372,773
G
SLC8A1
solute carrier family 8 member A1
ISO
mRNA, protein:decreased expression:cardiac muscle cell
RGD
PMID:10944172 RGD:1642714
NCBI chr 2:40,097,270...40,512,435
G
SLC9A1
solute carrier family 9 member A1
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:20003708
NCBI chr 1:27,098,809...27,155,125
G
SLC9A3
solute carrier family 9 member A3
ISO EXP
protein:increased activity:kidney cortex
CTD PMID:20003708 PMID:16244498 RGD:1625673
NCBI chr 5:470,456...524,449
G
SMAD1
SMAD family member 1
severity
ISO
protein:increased expression:glomerulus, urine
RGD
PMID:16482100 RGD:1643228
NCBI chr 4:145,480,770...145,559,176
G
SMARCA4
SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4
treatment
ISO
RGD
PMID:23853776 RGD:9586347
NCBI chr19:10,961,030...11,062,273
G
SMPD1
sphingomyelin phosphodiesterase 1
ISO
protein:decreased expression:gastrocnemius
RGD
PMID:14983401 RGD:1601347
NCBI chr11:6,390,474...6,394,996
G
SNAP25
synaptosome associated protein 25
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:16123366
NCBI chr20:10,218,830...10,307,418
G
SOAT2
sterol O-acyltransferase 2
ISO
RGD
PMID:15242859 RGD:1581191
NCBI chr12:53,103,486...53,124,535
G
SOCS3
suppressor of cytokine signaling 3
susceptibility
ISO
mRNA, protein:increased expression:retina
RGD PMID:18356406 PMID:17562326 RGD:2298911 , RGD:2313787
NCBI chr17:78,356,778...78,360,925
G
SOD1
superoxide dismutase 1
ISO EXP
protein:increased expression:hippocampus (rat)
CTD PMID:23090186 PMID:20924670 PMID:25541261 RGD:8655956 , RGD:405255664
NCBI chr21:31,659,693...31,668,931
G
SOD2
superoxide dismutase 2
ISO EXP
protein:increased activity:testes
CTD PMID:15855331 PMID:23090186 PMID:19891634 RGD:2317382
NCBI chr 6:159,669,069...159,762,281
G
SORD
sorbitol dehydrogenase
ISO
protein:increased expression:liver
RGD
PMID:15064821 RGD:1601360
NCBI chr15:45,023,195...45,077,185
G
SOX2
SRY-box transcription factor 2
ISO
RGD
PMID:23828673 RGD:8661677
NCBI chr 3:181,711,925...181,714,436
G
SPP1
secreted phosphoprotein 1
ISO
RGD
PMID:16528250 RGD:1581322
NCBI chr 4:87,975,714...87,983,411
G
SREBF1
sterol regulatory element binding transcription factor 1
treatment
ISO EXP
mRNA, protein:increased expression:renal proximal tubule, epithelial cell
CTD PMID:10900012 PMID:23090186 PMID:19048273 PMID:32535406 RGD:2308804 , RGD:401850547
NCBI chr17:17,811,334...17,836,986
G
SSTR1
somatostatin receptor 1
ISO
RGD
PMID:7956902 RGD:2325008
NCBI chr14:38,207,904...38,213,067
G
SSTR2
somatostatin receptor 2
ISO
RGD
PMID:7956902 RGD:2325008
NCBI chr17:73,165,010...73,176,633
G
SSTR3
somatostatin receptor 3
ISO
RGD
PMID:7956902 RGD:2325008
NCBI chr22:37,204,237...37,220,548
G
SSTR5
somatostatin receptor 5
ISO
RGD
PMID:7956902 RGD:2325008
NCBI chr16:1,072,747...1,081,454
G
STAR
steroidogenic acute regulatory protein
ISO
mRNA:decreased expression:sciatic nerve (rat)
RGD
PMID:20826654 RGD:4145530
NCBI chr 8:38,142,700...38,150,952
G
STAT1
signal transducer and activator of transcription 1
ISO
protein:increased tyrosine phosphorylation:glomerulus
RGD
PMID:14678947 RGD:1600105
NCBI chr 2:190,969,149...191,014,171
G
STAT3
signal transducer and activator of transcription 3
ISO
protein:increased tyrosine phosphorylation:aorta endothelium
RGD
PMID:18230613 PMID:22660795 RGD:2291921 , RGD:8694292
NCBI chr17:42,313,324...42,388,442
G
STAT4
signal transducer and activator of transcription 4
ISO
RGD
PMID:10553062 RGD:7207889
NCBI chr 2:191,029,576...191,151,596
G
STAT5B
signal transducer and activator of transcription 5B
ISO
RGD
PMID:17003334 RGD:2291940
NCBI chr17:42,199,177...42,288,370
G
STRA6
signaling receptor and transporter of retinol STRA6
ISO
protein:decreased expression:optic cup (rat)
RGD
PMID:28734946 RGD:155631297
NCBI chr15:74,179,466...74,212,259
G
STS
steroid sulfatase
EXP
CTD Direct Evidence: therapeutic
CTD PMID:24497646
NCBI chr X:7,147,290...7,354,641
G
TERT
telomerase reverse transcriptase
ISO
RGD
PMID:20031167 RGD:2316310
NCBI chr 5:1,253,167...1,295,068
G
TF
transferrin
ISO
RGD
PMID:17081048 RGD:1601532
NCBI chr 3:133,661,998...133,796,641
G
TGFB1
transforming growth factor beta 1
ISO EXP
protein:increased expression:urine
CTD PMID:17177138 PMID:23090186 PMID:15855808 RGD:1601583
NCBI chr19:41,330,323...41,353,922
G
TGFB2
transforming growth factor beta 2
ISO
protein:increased expression:parotid gland
RGD
PMID:17574405 RGD:2302087
NCBI chr 1:218,345,336...218,444,619
G
TH
tyrosine hydroxylase
ISO
protein:increased expression:seminal vesicle
RGD
PMID:17151307 RGD:1601629
NCBI chr11:2,163,929...2,171,815
G
THBS1
thrombospondin 1
ISO
RGD
PMID:17640965 RGD:2317942
NCBI chr15:39,581,079...39,599,466
G
TIMM44
translocase of inner mitochondrial membrane 44
ISO
protein:decreased expression:retina
RGD
PMID:23255365 RGD:13463486
NCBI chr19:7,926,718...7,943,666
G
TIMP1
TIMP metallopeptidase inhibitor 1
IMP EXP ISO
CTD Direct Evidence: marker/mechanism
CTD PMID:21963884 PMID:17192464 PMID:17569353 RGD:2312467 , RGD:2290354
NCBI chr X:47,582,436...47,586,789
G
TIMP2
TIMP metallopeptidase inhibitor 2
EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:21963884
NCBI chr17:78,852,977...78,925,387
G
TIMP3
TIMP metallopeptidase inhibitor 3
ISO
mRNA:increased expression:glomerulus
RGD
PMID:8840279 RGD:2312482
NCBI chr22:32,801,705...32,863,041
G
TJP1
tight junction protein 1
ISO
protein:decreased expression:glomerulus
RGD
PMID:16567508 RGD:2325150
NCBI chr15:29,699,367...29,969,049
G
TLR2
toll like receptor 2
ISO
mRNA:increased expression:gingiva
RGD
PMID:16740310 PMID:24878329 PMID:17707128 RGD:2312491 , RGD:597538517 , RGD:2312684
NCBI chr 4:153,684,280...153,710,637
G
TLR4
toll like receptor 4
ISO
mRNA:increased expression:gingiva
RGD
PMID:16740310 PMID:24878329 RGD:2312491 , RGD:597538517
NCBI chr 9:117,704,403...117,724,735
G
TNC
tenascin C
ISO
RGD
PMID:17999372 RGD:4889609
NCBI chr 9:115,019,575...115,118,157
G
TNF
tumor necrosis factor
treatment
ISO EXP
protein:increased expression:heart
CTD
PMID:12123627 PMID:12193562 PMID:19478208 PMID:20388520 PMID:22138235 PMID:24513509 PMID:20555424 PMID:19220660 PMID:24374093 PMID:21481476 More...
RGD:4142788 , RGD:2312478 , RGD:10450575 , RGD:5131250
NCBI chr 6:31,575,565...31,578,336
G
TNFRSF1A
TNF receptor superfamily member 1A
ISO EXP
protein:increased expression:liver (rat)
CTD PMID:12193562 PMID:21481476 RGD:5131250
NCBI chr12:6,328,771...6,342,076
G
TNFRSF1B
TNF receptor superfamily member 1B
IMP
human protein in rat model
RGD
PMID:21481476 RGD:5131250
NCBI chr 1:12,166,991...12,209,220
G
TNFSF10
TNF superfamily member 10
ISO IMP
RGD
PMID:12577054 PMID:18649770 PMID:19572802 RGD:2312744 , RGD:2312738 , RGD:2312737
NCBI chr 3:172,505,508...172,523,430
G
TOMM40
translocase of outer mitochondrial membrane 40
ISO
protein:decreased expression:retina
RGD
PMID:23255365 RGD:13463486
NCBI chr19:44,891,254...44,903,689
G
TOMM70
translocase of outer mitochondrial membrane 70
ISO
protein:decreased expression:retina
RGD
PMID:23255365 RGD:13463486
NCBI chr 3:100,363,431...100,401,089
G
TP53
tumor protein p53
ISO EXP
CTD Direct Evidence: marker/mechanism
CTD PMID:21078376 PMID:23792339 PMID:24828139 RGD:8662307
NCBI chr17:7,668,421...7,687,490
G
TP63
tumor protein p63
ISO
protein:increased expression:prostate gland
RGD
PMID:20041964 RGD:11568648
NCBI chr 3:189,596,746...189,897,276
G
TPI1
triosephosphate isomerase 1
ISO
protein:decreased expression:retina
RGD
PMID:17465459 RGD:5147874
NCBI chr12:6,867,420...6,870,948
G
TREX2
three prime repair exonuclease 2
ISO
RGD
PMID:20973890 RGD:5490977
NCBI chr X:153,444,473...153,446,056
G
TRPC1
transient receptor potential cation channel subfamily C member 1
ISO
mRNA:decreased expression:kidney, liver
RGD
PMID:18184923 RGD:2301838
NCBI chr 3:142,724,034...142,807,888
G
TSC2
TSC complex subunit 2
ISO
protein:increased threonine phosphorylation:cortex of kidney
RGD
PMID:18599524 RGD:8657153
NCBI chr16:2,047,985...2,089,491
G
TWNK
twinkle mtDNA helicase
ISO
mRNA,protein:decreased expression:retina,mitochondrion:
RGD
PMID:22743328 PMID:22229649 RGD:8694093 , RGD:8694187
NCBI chr10:100,987,543...100,994,403
G
TXN
thioredoxin
ISO
mRNA:altered expression:myocardium (rat)
RGD
PMID:20571744 RGD:5133714
NCBI chr 9:110,243,810...110,256,507
G
TXN2
thioredoxin 2
ISO
mRNA:increased expression:glomerulus
RGD
PMID:15039483 PMID:20571744 RGD:2306161 , RGD:5133714
NCBI chr22:36,467,046...36,481,640
G
TXNIP
thioredoxin interacting protein
ISO
protein:increased expression:kidney
RGD
PMID:17675577 RGD:1642749
NCBI chr 1:145,992,435...145,996,579
G
TXNRD1
thioredoxin reductase 1
ISO
mRNA:altered expression:myocardium (rat)
RGD
PMID:20571744 RGD:5133714
NCBI chr12:104,215,779...104,350,307
G
TXNRD2
thioredoxin reductase 2
ISO
mRNA:altered expression:myocardium (rat)
RGD
PMID:20571744 RGD:5133714
NCBI chr22:19,875,522...19,941,818
G
UBA52
ubiquitin A-52 residue ribosomal protein fusion product 1
ISO
mRNA:increased expression:kidney (mouse)
RGD
PMID:12171997 RGD:11352735
NCBI chr19:18,563,766...18,577,550
G
UCHL5
ubiquitin C-terminal hydrolase L5
ISO
RGD
PMID:23500140 RGD:9588239
NCBI chr 1:193,012,254...193,060,076
G
UCK2
uridine-cytidine kinase 2
ISO
protein:decreased activity:heart, skeletal muscle
RGD
PMID:221781 RGD:2317214
NCBI chr 1:165,827,614...165,911,618
G
UCP2
uncoupling protein 2
ISO EXP
protein:increased expression:kidney
CTD PMID:14563825 PMID:16123366 PMID:19227473 RGD:2313501
NCBI chr11:73,974,672...73,983,202
G
UCP3
uncoupling protein 3
susceptibility
IMP ISO
mRNA:increased expression:skeletal muscle
RGD
PMID:12079841 PMID:10868941 RGD:2313520 , RGD:2313524
NCBI chr11:74,000,277...74,009,085
G
UGT2B17
UDP glucuronosyltransferase family 2 member B17
ISO
mRNA:increased expression:liver
RGD
PMID:20487213 RGD:11541075
NCBI chr 4:68,537,173...68,576,322
G
UMOD
uromodulin
ISO
protein:increased expression:urine
RGD
PMID:10925066 RGD:2324705
NCBI chr16:20,333,051...20,356,301
G
UMPS
uridine monophosphate synthetase
ISO
protein:decreased activity:mammary gland (rat)
RGD
PMID:1476792 PMID:3907307 RGD:5132591 , RGD:5132278
NCBI chr 3:124,730,452...124,749,273
G
UPRT
uracil phosphoribosyltransferase homolog
ISO
protein:decreased activity:mammary gland (rat)
RGD
PMID:1476792 RGD:5132591
NCBI chr X:75,156,369...75,304,897
G
UTS2R
urotensin 2 receptor
ISO
RGD
PMID:16267137 RGD:2306839
NCBI chr17:82,371,765...82,377,458
G
VCAM1
vascular cell adhesion molecule 1
ISO
mRNA, protein:increased expression:kidney
RGD
PMID:18983856 PMID:18093596 RGD:2312764 , RGD:2306988
NCBI chr 1:100,719,742...100,739,045
G
VDAC1
voltage dependent anion channel 1
ISO
protein:increased expression:kidney
RGD
PMID:19634143 RGD:10003054
NCBI chr 5:133,971,871...134,114,540
G
VEGFA
vascular endothelial growth factor A
ISO EXP
mRNA:decreased expression:skeletal muscle
CTD PMID:22191573 PMID:16816123 PMID:19934008 PMID:16741021 RGD:2313725 , RGD:7421582 , RGD:2313724
NCBI chr 6:43,770,211...43,786,487
G
VEGFB
vascular endothelial growth factor B
ISO
mRNA:decreased expression:skeletal muscle
RGD
PMID:16816123 RGD:2313725
NCBI chr11:64,234,584...64,239,264
G
VIP
vasoactive intestinal peptide
ISO
RGD
PMID:21129425 RGD:5685622
NCBI chr 6:152,750,797...152,759,760
G
VIPR1
vasoactive intestinal peptide receptor 1
ISO
RGD
PMID:21129425 RGD:5685622
NCBI chr 3:42,489,299...42,537,568
G
VLDLR
very low density lipoprotein receptor
ISO
protein:decreased expression:heart, skeletal muscle
RGD
PMID:15878964 RGD:1625575
NCBI chr 9:2,621,787...2,660,056
G
VWF
von Willebrand factor
ISO
protein:increased expression:plasma
RGD
PMID:17546272 RGD:1625712
NCBI chr12:5,948,877...6,124,670
G
WDR35
WD repeat domain 35
ISO
mRNA:increased expression:kidney (rat)
RGD
PMID:20224876 RGD:11553923
NCBI chr 2:19,910,263...19,990,105
G
XDH
xanthine dehydrogenase
ISO
protein:increased expression:brain, heart, kidney
RGD
PMID:14532905 RGD:1304441
NCBI chr 2:31,334,321...31,414,742
G
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
EXP
CTD Direct Evidence: therapeutic
CTD PMID:18342293
NCBI chr22:31,944,535...31,957,603
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