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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Cocaine-Related Disorders
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Accession:DOID:9005632 term browser browse the term
Definition:Disorders related or resulting from use of cocaine.
Synonyms:exact_synonym: cocaine-related disorder
 narrow_synonym: cocaine use disorder
 primary_id: MESH:D019970
 xref: EFO:0010445


show annotations for term's descendants           Sort by:
Cocaine-Related Disorders term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase treatment IMP RGD PMID:22128851 RGD:9588542 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Apol2 apolipoprotein L2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 7:109,331,367...109,338,632
Ensembl chr 7:109,331,392...109,338,558 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18311559 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Atp9b ATPase phospholipid transporting 9B (putative) ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr18:74,176,863...74,368,993
Ensembl chr18:74,176,863...74,368,953 		JBrowse link
G Avp arginine vasopressin susceptibility ISO DNA:SNP:intron: (rs2282018) (human) RGD PMID:24766650 RGD:401976505 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bche butyrylcholinesterase ISO CTD Direct Evidence: therapeutic CTD PMID:18292872 PMID:18514640 PMID:20060817 PMID:20971807 PMID:22935511 More... NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bdnf brain-derived neurotrophic factor severity
susceptibility 		ISO
IMP 		CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD		 PMID:14973246 PMID:17618281 PMID:17651427 PMID:18311559 PMID:19321768 More... RGD:38501054, RGD:38501054 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bdnfem1Sage brain-derived neurotrophic factor; ZFN induced mutant 1, Sage severity IMP RGD PMID:23583595 RGD:38501054
G Calm1 calmodulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:119,487,621...119,498,227 		JBrowse link
G Calm2 calmodulin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:14725635 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV ISO CTD Direct Evidence: marker/mechanism CTD PMID:19001277 NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,585,269...24,802,487 		JBrowse link
G Cartpt CART prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:20886038 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713 		JBrowse link
G Cckbr cholecystokinin B receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9922984 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881 		JBrowse link
G Ccser1 coiled-coil serine-rich protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 4:90,153,873...91,391,441
Ensembl chr 4:90,292,780...91,388,786 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 ISO RGD PMID:11268215 RGD:734739 NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Ces1d carboxylesterase 1D ISO CTD Direct Evidence: therapeutic CTD PMID:12679808 PMID:12773168 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2h carboxylesterase 2H ISO CTD Direct Evidence: therapeutic CTD PMID:19710369 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Cfl1 cofilin 1 IEP protein:altered expression:striatum (rat) RGD PMID:27018876 RGD:11568696 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:13130510 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16314880 PMID:17596442 PMID:19052543 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cobll1 cordon-bleu WH2 repeat protein-like 1 ISO mRNA:increased expressio:nucleus accumbens (mouse) RGD PMID:27506785 RGD:11561325 NCBI chr 3:49,753,260...49,915,168
Ensembl chr 3:49,753,262...49,915,194 		JBrowse link
G Comt catechol-O-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18704099 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11717377 PMID:16359811 PMID:18596687 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crh corticotropin releasing hormone IEP
ISO 		mRNA:decreased expression:hypothalamus (rat)
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:7796157 PMID:10516337 PMID:11797056 PMID:18596687 PMID:19349312 More... RGD:5508177 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Crhbp corticotropin releasing hormone binding protein susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:3'UTR: (rs1875999) (HUMAN) 		CTD
RGD		 PMID:17437087 PMID:24766650 RGD:401976505 NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IEP
ISO 		mRNA:increased expression:anterior pituitary (rat)
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:19339610 PMID:12576179 RGD:5508175 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17437087 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904 		JBrowse link
G Dnah8 dynein, axonemal, heavy chain 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr20:8,692,939...8,946,780
Ensembl chr20:8,692,963...8,946,772 		JBrowse link
G Drd1 dopamine receptor D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15295029 PMID:16014726 PMID:16541082 PMID:20456009 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 IDA
ISO 		protein:increased activity:caudate putamen (rat)
CTD Direct Evidence: marker/mechanism|therapeutic 		CTD
RGD		 PMID:10900248 PMID:11751029 PMID:11923462 PMID:15010698 PMID:15042275 More... RGD:2311586 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:10523822 PMID:15100700 PMID:17332411 PMID:18566292 PMID:20494958 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Egr1 early growth response 1 treatment IEP
ISO 		CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD		 PMID:16157275 PMID:16738229 PMID:18311559 PMID:25309368 PMID:21309948 RGD:10395309, RGD:10400880 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:20056891 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547 		JBrowse link
G Esr2 estrogen receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17133264 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Fgf2 fibroblast growth factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19014962 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO
IEP 		CTD Direct Evidence: marker/mechanism
protein:increased expression:brain 		CTD
RGD		 PMID:17276011 PMID:18311559 PMID:19533625 PMID:14741756 RGD:405255650 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:12657709 PMID:17898221 PMID:18539927 PMID:19331462 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Fryl FRY like transcription coactivator ISO mRNA:increased expression:nucleus accumbens (mouse) RGD PMID:27506785 RGD:11561325 NCBI chr14:34,956,623...35,189,738
Ensembl chr14:34,956,620...35,190,222 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ameliorates ISO RGD PMID:35185557 RGD:408345254 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19833324 PMID:20133874 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gad1 glutamate decarboxylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Galr1 galanin receptor 1 susceptibility ISO DNA:SNP:intron: (rs2717162) (human) RGD PMID:24766650 RGD:401976505 NCBI chr18:75,772,021...75,787,577
Ensembl chr18:75,772,023...75,787,577 		JBrowse link
G Gcc1 GRIP and coiled-coil domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 4:57,030,817...57,042,682
Ensembl chr 4:57,032,314...57,042,663 		JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO CTD Direct Evidence: therapeutic CTD PMID:14622243 PMID:15899247 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:17407494 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
G Gphn gephyrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612 		JBrowse link
G Gpsm1 G-protein signaling modulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15091342 NCBI chr 3:9,140,816...9,167,828
Ensembl chr 3:9,128,636...9,167,827 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:14684464 PMID:15764012 PMID:16495937 PMID:18430032 PMID:18486119 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18945913 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16014726 PMID:20149346 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO protein:decreased expression:prefrontal cortex (human) RGD PMID:23727505 RGD:13792719 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO protein:decreased expression:prefrontal cortex (human) RGD PMID:23727505 RGD:13792719 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO protein:decreased expression:prefrontal cortex (human) RGD PMID:23727505 RGD:13792719 NCBI chr 1:270,014,314...270,208,294
Ensembl chr 1:260,028,242...260,218,701 		JBrowse link
G Grm2 glutamate metabotropic receptor 2 IMP knockout compared to wild type RGD PMID:28700935 RGD:38501064 NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146 		JBrowse link
G Grm2em1 glutamate metabotropic receptor 2; endonuclease induced mutant 1 IMP KO compared to wild-type rats RGD PMID:28700935 RGD:38501064
G Grm5 glutamate metabotropic receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20826661 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274 		JBrowse link
G Hcrt hypocretin neuropeptide precursor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16357203 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Hcrtr1 hypocretin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16357203 PMID:19591850 PMID:19741128 NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:142,477,214...142,486,674 		JBrowse link
G Hdac4 histone deacetylase 4 ISO CTD Direct Evidence: therapeutic CTD PMID:17988634 NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac5 histone deacetylase 5 ISO CTD Direct Evidence: therapeutic CTD PMID:17988634 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Homer1 homer scaffold protein 1 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:16160706 PMID:16314758 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785 		JBrowse link
G Homer2 homer scaffold protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15545022 NCBI chr 1:135,558,977...135,659,780
Ensembl chr 1:135,567,414...135,659,772 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:11853856 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:9603521 PMID:17509084 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Cocaine-Related Disorders 		CTD
ClinVar		 PMID:9635956 PMID:11259563 PMID:12476319 PMID:15364038 PMID:16300424 More... NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr3b 5-hydroxytryptamine receptor 3B susceptibility ISO DNA:SNP:cds:rs1176744(human) RGD PMID:20838391 RGD:6480660 NCBI chr 8:49,279,291...49,308,444
Ensembl chr 8:49,279,173...49,308,444 		JBrowse link
G Ice2 interactor of little elongation complex ELL subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 8:70,043,419...70,085,217
Ensembl chr 8:70,043,424...70,084,995 		JBrowse link
G Ilk integrin-linked kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18702665 PMID:19629758 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: therapeutic CTD PMID:17898221 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Klhl5 kelch-like family member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr14:43,144,254...43,206,192
Ensembl chr14:43,144,257...43,184,238 		JBrowse link
G Lhb luteinizing hormone subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:12893845 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lrrc7 leucine rich repeat containing 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 2:247,146,616...247,634,945
Ensembl chr 2:247,147,752...247,634,547 		JBrowse link
G Manea mannosidase, endo-alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 PMID:19255376 NCBI chr 5:40,196,373...40,218,540
Ensembl chr 5:40,196,396...40,218,459 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16407894 PMID:20692647 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20692647 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mecp2 methyl CpG binding protein 2 treatment ISO
IMP 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20711185 PMID:20711185 RGD:12789445 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
G Mir130a microRNA 130a ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629 		JBrowse link
G Mir136 microRNA 136 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 6:128,549,096...128,549,177
Ensembl chr 6:128,549,096...128,549,177 		JBrowse link
G Mir137 microRNA 137 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 2:206,480,881...206,480,982
Ensembl chr 2:206,480,884...206,480,985 		JBrowse link
G Mir138-1 microRNA 138-1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 8:122,300,966...122,301,064
Ensembl chr 8:122,300,966...122,301,064 		JBrowse link
G Mir148b microRNA 148b ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 7:134,421,398...134,421,494
Ensembl chr 7:134,421,398...134,421,494 		JBrowse link
G Mir154 microRNA 154 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 6:128,752,947...128,753,030
Ensembl chr 6:128,752,947...128,753,030 		JBrowse link
G Mir186 microRNA 186 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 2:246,582,806...246,582,891
Ensembl chr 2:246,582,806...246,582,891 		JBrowse link
G Mir212 microRNA 212 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20613834 PMID:20711185 NCBI chr10:60,023,403...60,023,513
Ensembl chr10:60,023,403...60,023,513 		JBrowse link
G Mir301b microRNA 301b ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr11:83,879,816...83,879,893
Ensembl chr11:83,879,816...83,879,893 		JBrowse link
G Mir324 microRNA 324 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr10:54,734,680...54,734,762
Ensembl chr10:54,734,678...54,734,766 		JBrowse link
G Mir337 microRNA 337 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 6:128,538,903...128,538,999
Ensembl chr 6:128,538,902...128,538,998 		JBrowse link
G Mir488 microRNA 488 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr13:70,683,064...70,683,142
Ensembl chr13:70,683,064...70,683,142 		JBrowse link
G Mir500 microRNA 500 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr  X:15,258,778...15,258,857
Ensembl chr  X:15,258,768...15,258,859 		JBrowse link
G Mir544 microRNA 544 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 6:128,743,530...128,743,607
Ensembl chr 6:128,743,530...128,743,607 		JBrowse link
G Mir665 microRNA 665 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 6:128,539,440...128,539,533
Ensembl chr 6:128,539,440...128,539,533 		JBrowse link
G Mxd1 max dimerization protein 1 ameliorates ISO RGD PMID:27506785 RGD:11561325 NCBI chr 4:120,654,731...120,678,972
Ensembl chr 4:119,097,353...119,117,751 		JBrowse link
G Ngf nerve growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:17715210 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nps neuropeptide S ISO CTD Direct Evidence: marker/mechanism CTD PMID:19339610 PMID:20974945 PMID:21466221 NCBI chr 1:190,077,040...190,080,821
Ensembl chr 1:190,077,040...190,080,821 		JBrowse link
G Npsr1 neuropeptide S receptor 1 treatment IMP RGD PMID:22982682 RGD:9831202 NCBI chr 8:22,606,946...22,831,558
Ensembl chr 8:22,606,946...22,831,558 		JBrowse link
G Npy neuropeptide Y ISO CTD Direct Evidence: marker/mechanism CTD PMID:19063928 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Npy2r neuropeptide Y receptor Y2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18828811 NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12805318 PMID:19234455 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 susceptibility ISO DNA:SNP:intron: (rs1040288) (human) RGD PMID:24766650 RGD:401976505 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20826313 PMID:20947769 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Oprk1 opioid receptor, kappa 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18575850 PMID:20232055 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12815747 PMID:16893609 PMID:18762918 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdyn prodynorphin ISO
IEP
IMP 		CTD Direct Evidence: marker/mechanism
mRNA:altered expression:brain
DNA:VNTR:promoter 		CTD
RGD		 PMID:16184603 PMID:17559549 PMID:18575850 PMID:18923396 PMID:8840025 More... RGD:401851906, RGD:401850568, RGD:401850567 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:11750770 PMID:16520439 PMID:18201294 PMID:19279569 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:15064918 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prmt1 protein arginine methyltransferase 1 ISO mRNA:decreased exoression:nucleus accumbens (mouse) RGD PMID:27506785 RGD:11561325 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345 		JBrowse link
G Prmt2 protein arginine methyltransferase 2 ISO mRNA:decreased expression:nucleus accumbens (mouse) RGD PMID:27506785 RGD:11561325 NCBI chr20:12,394,748...12,420,643
Ensembl chr20:12,394,798...12,420,643 		JBrowse link
G Prmt5 protein arginine methyltransferase 5 ISO mRNA:decreased expression:nucleus accumbens (mouse) RGD PMID:27506785 RGD:11561325 NCBI chr15:31,938,927...31,948,318
Ensembl chr15:27,968,910...27,978,296 		JBrowse link
G Prmt6 protein arginine methyltransferase 6 treatment ISO
IEP 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:27506785 PMID:27506785 PMID:27506785 RGD:11561325, RGD:11561325 NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648 		JBrowse link
G Prmt8 protein arginine methyltransferase 8 ISO mRNA:decreased expression:nucleus accumbens (mouse) RGD PMID:27506785 RGD:11561325 NCBI chr 4:160,535,813...160,618,193
Ensembl chr 4:160,535,813...160,617,930 		JBrowse link
G Prmt9 protein arginine methyltransferase 9 ISO mRNA:decreased expression:nucleus accumbens (mouse) RGD PMID:27506785 RGD:11561325 NCBI chr19:30,376,342...30,414,491
Ensembl chr19:30,380,124...30,414,458 		JBrowse link
G Rhoa ras homolog family member A ISO CTD Direct Evidence: marker/mechanism CTD PMID:30158054 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16339038 NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224 		JBrowse link
G Runx2 RUNX family transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30158054 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12736327 PMID:16132061 NCBI chr 5:56,904,155...56,907,012
Ensembl chr 5:56,904,159...56,907,017 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 ISO CTD Direct Evidence: therapeutic CTD PMID:19625514 NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:11320258 PMID:11746736 PMID:16537431 PMID:19602552 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 susceptibility ISO protein:decreased activity: :
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:11320258 PMID:20838391 RGD:6480660 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Smad1 SMAD family member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30158054 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651 		JBrowse link
G Smad3 SMAD family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27422367 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad5 SMAD family member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30158054 NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634 		JBrowse link
G Smarca4 SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27422367 NCBI chr 8:28,438,370...28,535,071
Ensembl chr 8:20,167,717...20,258,975 		JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30158054 NCBI chr12:14,748,717...14,840,273
Ensembl chr12:9,635,025...9,726,519 		JBrowse link
G Snca synuclein alpha ISO mRNA,protein:increased expression:dopamine neuron
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:18055133 PMID:12684441 RGD:6480198 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sncg synuclein, gamma IMP RGD PMID:20579003 RGD:6218958 NCBI chr16:9,706,765...9,712,072
Ensembl chr16:9,700,514...9,705,368 		JBrowse link
G Srcin1 SRC kinase signaling inhibitor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:27506785 NCBI chr10:82,502,911...82,569,882
Ensembl chr10:82,504,393...82,571,040 		JBrowse link
G Syt13 synaptotagmin 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 3:78,877,114...78,917,527
Ensembl chr 3:78,877,114...78,917,392 		JBrowse link
G Tacr3 tachykinin receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18422838 NCBI chr 2:223,266,536...223,363,791
Ensembl chr 2:223,266,536...223,363,791 		JBrowse link
G Tenm3 teneurin transmembrane protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr16:41,251,909...43,978,594
Ensembl chr16:41,252,182...43,978,594 		JBrowse link
G Tyk2 tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044 		JBrowse link
G Usp46 ubiquitin specific peptidase 46 ISO mRNA:increased expression:nucleus accumbens (mouse) RGD PMID:27506785 RGD:11561325 NCBI chr14:34,150,055...34,219,227
Ensembl chr14:34,150,004...34,219,227 		JBrowse link
cocaine abuse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase severity ISO RGD PMID:21540357 RGD:401960084 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bdnf brain-derived neurotrophic factor ISO mRNA:increased expression:nucleus accumbens RGD PMID:31280332 RGD:596948400 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 ISO mRNA:decreased expression:caudate-putamen (mouse) RGD PMID:15994025 RGD:405866348 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Cartpt CART prepropeptide ISO mRNA:increased expression:nucleus accumbens RGD PMID:15009677 RGD:597805894 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 severity ISO RGD PMID:21806491 RGD:401794583 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cd40lg CD40 ligand severity ISO RGD PMID:21806491 RGD:401794583 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit onset ISO DNA:SNP:exon:rs16969968(human) RGD PMID:32841724 RGD:150530292 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit susceptibility ISO DNA:SNP::rs892413(human) RGD PMID:24675634 RGD:405849277 NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit onset ISO DNA:SNP::rs950776(human) RGD PMID:32841724 RGD:150530292 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Clock clock circadian regulator ISO mRNA:increased expression:caudate-putamen (mouse) RGD PMID:15994025 RGD:405866348 NCBI chr14:32,262,747...32,346,872
Ensembl chr14:31,908,566...31,990,400 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO
IDA 		protein:increased expression, increased phosphorylation:prefrontal cortex RGD PMID:24205196 PMID:18001273 RGD:401940185, RGD:401959587 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cry1 cryptochrome circadian regulator 1 ISO mRNA:decreased expression:caudate-putamen (mouse) RGD PMID:15994025 RGD:405866347 NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091 		JBrowse link
G Fgf2 fibroblast growth factor 2 IEP mRNA:increased expression:nucleus accumbens (rat) RGD PMID:27114539 RGD:405855871 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 sexual_dimorphism IEP mRNA:increased expression:brain (rat) RGD PMID:31029877 RGD:401976486 NCBI chr20:6,458,931...6,577,227
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment ISO RGD PMID:28366798 RGD:405100962 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit IEP
ISO 		associated with alcohol dependence;protein:increased expression: caudate-putamen (rat) RGD PMID:17572394 PMID:9294222 RGD:401900302, RGD:407446380 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 sexual_dimorphism ISO
IEP 		protein:increased expression:prefrontal cortex (mouse)
protein:increased expression:nucleus accumbens (rat)
protein:decreased expression:nucleus accumbens (mouse) 		RGD PMID:33497752 PMID:11801363 PMID:22197517 RGD:401976469, RGD:405650201, RGD:405650197 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Hcrt hypocretin neuropeptide precursor treatment ISO RGD PMID:29454841 RGD:401960065 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A IEP protein:decreased expression:dentate gyrus, hypothalamus RGD PMID:9723786 RGD:401900605 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A treatment IEP
IMP 		mRNA:increased expression:orbitofrontal cortex RGD PMID:27733540 PMID:20814782 PMID:11259563 RGD:401900753, RGD:401901179, RGD:401900755 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C treatment IMP RGD PMID:20814782 RGD:401901179 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IDA protein:increased phosphorylation:nucleus accumbens RGD PMID:25522720 RGD:401851063 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IDA protein:increased phosphorylation:nucleus accumbens RGD PMID:25522720 RGD:401851063 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mb myoglobin ISO protein:increased expression:umbilical cord blood RGD PMID:8989474 RGD:458925290 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383 		JBrowse link
G Npas2 neuronal PAS domain protein 2 ISO mRNA:decreased expression:hippocampal formation,caudate-putamen (mouse) RGD PMID:15994025 RGD:405866347 NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 susceptibility ISO DNA:SNP:intron: (rs4518200) (human) RGD PMID:33242852 RGD:402463938 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 treatment IMP
ISO 		mRNA:decreased expression:blood RGD PMID:12805318 PMID:29761890 PMID:9765324 RGD:401976288, RGD:407987269, RGD:401976376 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 treatment ISO mRNA:increased expression:nucleus accumbens RGD PMID:27576164 PMID:31280332 RGD:596948399, RGD:596948400 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Pdyn prodynorphin IEP mRNA:increased expression:caudate putamen
mRNA:increased expression:central amygdaloid nucleus, dentate gyrus of hippocampal formation 		RGD PMID:7694032 PMID:12523490 RGD:401850578, RGD:401850585 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Per1 period circadian regulator 1 ISO mRNA:increased expression:hippocampal formation, caudate-putamen (mouse) RGD PMID:15994025 RGD:405866348 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431 		JBrowse link
G Per2 period circadian regulator 2 ISO mRNA:increased expression, decreased expression:hippocampal formation, caudate-putamen (mouse) RGD PMID:15994025 RGD:405866348 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459 		JBrowse link
G Prl prolactin treatment ISO RGD PMID:17391744 RGD:401960113 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Tlr2 toll-like receptor 2 ISO protein:increased expression:striatum, microglial cell RGD PMID:26860188 RGD:597538483 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
cocaine dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2a activin A receptor type 2A ameliorates IMP RGD PMID:26030849 RGD:597830060 NCBI chr 3:33,204,961...33,292,673
Ensembl chr 3:33,205,523...33,289,968 		JBrowse link
G Ankk1 ankyrin repeat and kinase domain containing 1 treatment ISO DNA:SNP: :rs1800497(human) RGD PMID:23635803 RGD:401959203 NCBI chr 8:49,779,862...49,788,024
Ensembl chr 8:49,779,862...49,788,024 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein ISO protein:increased expression:dorsal striatum, shell of nucleus accumbens (mouse) RGD PMID:27567310 RGD:401901591 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Avp arginine vasopressin IEP protein:increased expression:nucleus accumbens RGD PMID:19596360 RGD:408426004 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bdnf brain-derived neurotrophic factor ISO
IMP 		RGD PMID:14973246 PMID:18990365 RGD:401965389, RGD:596933098 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV no_association ISO DNA:SNP: :rs919334
DNA:SNPs: :rs1457115, rs9285875 		RGD PMID:19001277 PMID:19001277 RGD:401938643, RGD:401938643 NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,585,269...24,802,487 		JBrowse link
G Ccser1 coiled-coil serine-rich protein 1 susceptibility ISO DNA:SNP:: (rs1381355) (human) RGD PMID:18438686 RGD:401851917 NCBI chr 4:90,153,873...91,391,441
Ensembl chr 4:90,292,780...91,388,786 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit susceptibility ISO DNA:missense:exons:p.R37H,p.E363D(human) RGD PMID:24057674 RGD:405849397 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit susceptibility ISO DNA:missense:exons:multiple(human) RGD PMID:24057674 RGD:405849397 NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360 		JBrowse link
G Comt catechol-O-methyltransferase susceptibility ISO DNA:SNPs,haplotypes:exon: p.V158M (rs4680, rs737865, rs165688) (human) RGD PMID:18704099 RGD:401959302 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment
no_association
sexual_dimorphism 		IEP
ISO
IDA 		DNA:SNPs: :rs10876469, rs2177000
protein:increased phosphorylation:nucleus accumbens, prefrontal cortex 		RGD PMID:27664298 PMID:19001277 PMID:23665060 PMID:25522720 RGD:401900166, RGD:401938643, RGD:401851078, RGD:401851063 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Drd2 dopamine receptor D2 treatment
sexual_dimorphism 		IMP
ISO 		DNA:SNP: :rs2283265(human)
female only;DNA:SNP: :rs2283265(human) 		RGD PMID:29454035 PMID:23635803 PMID:30367264 RGD:13506950, RGD:401959203, RGD:401959597 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Egr1 early growth response 1 treatment IEP RGD PMID:26674058 RGD:405100964 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment
severity 		IEP protein:increased expression:brain
mRNA:increased expression:brain
protein:increased expression:habenula 		RGD PMID:26674058 PMID:24633559 PMID:18310906 PMID:18488248 PMID:29139213 RGD:405100964, RGD:405100965, RGD:405101699, RGD:401959615, RGD:401900161 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ameliorates
treatment 		IEP
ISO 		protein:increased expression:Nucleus Accumbens, Caudate Putamen (rat)
protein:increased expression:Brain (rat)
mRNA,protein:increased expression:Nucleus Accumbens, Caudate Putamen (rat)
protein:increased expression:dorsal striatum, nucelus accumbens (mouse) 		RGD PMID:25522720 PMID:23665060 PMID:22403532 PMID:27664298 PMID:20633205 More... RGD:401851063, RGD:401851078, RGD:401851084, RGD:401900166, RGD:401900126, RGD:401901287 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 susceptibility ISO DNA:SNP:intron: C>G (rs29220) (human)
mRNA:decreased expression:hippocampus (human) 		RGD PMID:22253714 PMID:26727527 RGD:401900163, RGD:11552767 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 ISO mRNA:decreased expression:hippocampus (human) RGD PMID:22253714 RGD:401900163 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gad1 glutamate decarboxylase 1 ISO mRNA:decreased expression:hippocampus RGD PMID:22253714 RGD:401900163 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 ISO mRNA:decreased expression:hippocampus RGD PMID:22253714 RGD:401900163 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 exacerbates
treatment 		IMP
IEP
ISO 		protein:increased expression:ventral tegmental area (rat)
protein:increased phosphorylation:hippocampal formation (mouse)
protein:increased phosphorylation:prefrontal cortex, premotor cortex (rat)
protein:increased expression:nucleus accumbens cell surface (rat)
protein:increased expression, increased phosphorylation:hippocampal formation, postsynaptic density (mouse)
protein:increased expression:nucleus accumbens (rat) 		RGD PMID:18430032 PMID:21613507 PMID:25539504 PMID:29196318 PMID:18554320 More... RGD:405096666, RGD:405100712, RGD:405649730, RGD:405649733, RGD:405649734, RGD:405650586, RGD:405650670, RGD:405818274, RGD:405818277, RGD:405820206, RGD:405820210, RGD:408364954 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 treatment IMP RGD PMID:20555310 RGD:408364961 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Grm5 glutamate metabotropic receptor 5 ameliorates IDA
ISO 		RGD PMID:19100966 PMID:21319882 PMID:24795154 RGD:598099552, RGD:598099553, RGD:598099566 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 susceptibility ISO DNA:polymorphism:CDS:p.Ile105Val RGD PMID:16272961 RGD:597621685 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A treatment ISO
IMP 		DNA:SNP: :rs6561333 RGD PMID:23241418 PMID:23336050 PMID:15849375 RGD:401900299, RGD:401900743, RGD:401900756 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C treatment IMP RGD PMID:23336050 RGD:401900743 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A ISO DNA:SNPs, haplotype:exon, intron: (rs1985242, rs2276302, rs4938066) (human)
DSNA:SNP:intron:g.113985089A>G (rs897687) (human) 		RGD PMID:24590108 PMID:26227246 RGD:404976878, RGD:405096480 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Klhl5 kelch-like family member 5 susceptibility ISO DNA:SNP:: (rs1046655) (human) RGD PMID:18438686 RGD:401851917 NCBI chr14:43,144,254...43,206,192
Ensembl chr14:43,144,257...43,184,238 		JBrowse link
G Lrrc7 leucine rich repeat containing 7 susceptibility ISO DNA:SNP: (rs1938584) (human) RGD PMID:18438686 RGD:401851917 NCBI chr 2:247,146,616...247,634,945
Ensembl chr 2:247,147,752...247,634,547 		JBrowse link
G Manea mannosidase, endo-alpha susceptibility ISO DNA:SNPs:multiple RGD PMID:19255376 RGD:401851915 NCBI chr 5:40,196,373...40,218,540
Ensembl chr 5:40,196,396...40,218,459 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IDA protein:increased phosphorylation:brain RGD PMID:23665060 RGD:401851078 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IDA protein:increased phosphorylation:brain RGD PMID:23665060 RGD:401851078 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ngf nerve growth factor ISO protein:decreased expression:serum RGD PMID:17715210 RGD:401976440 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IEP mRNA:decreased expression:adenohypophysis RGD PMID:12892653 RGD:408345227 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 treatment IMP RGD PMID:18990365 PMID:27488635 PMID:31417375 RGD:596933098, RGD:596933099, RGD:596933359 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Oprd1 opioid receptor, delta 1 treatment
susceptibility 		ISO DNA:SNP,haplotype:intron 1 (rs2298896|rs421300), multiple GCAAT (human)
DNA:SNP:intron,cds (rs678849,rs2234918) (human)
associated with opiate dependence;DNA:SNP:intron (rs678849) (human)
associated with alcohol use disorder; DNA:SNP:intron (rs678849) (human)
DNA:SNPs, haplotype:intron 1 (rs2298896|rs421300) (human) 		RGD PMID:17622222 PMID:22795689 PMID:33953123 PMID:27449273 PMID:24533225 RGD:401976552, RGD:401976559, RGD:402463937, RGD:402463960, RGD:402525443 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 ISO DNA:SNPs:intron:rs6473797, rs10111937 RGD PMID:34843875 RGD:401851040 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO mRNA:increased expression:nucleus accumbens RGD PMID:29992335 RGD:401831041 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdyn prodynorphin susceptibility ISO DNA, mRNA:SNPs, haplotype:3' utr:rs910080, rs910079, rs2235749 (human)
DNA:VNTR:Promoter
mRNA:increased expression:caudate-putamen
mRNA:increased expression:nucleus accumbens 		RGD PMID:18923396 PMID:16184603 PMID:23164614 PMID:22390687 RGD:401850550, RGD:401850583, RGD:401850589, RGD:401851043 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Per2 period circadian regulator 2 susceptibility ISO DNA:repeats:: RGD PMID:22832851 RGD:401976513 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459 		JBrowse link
G Ppbp pro-platelet basic protein ISO protein:increased expression:plasma RGD PMID:21806491 RGD:401794583 NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130 		JBrowse link
G Prl prolactin severity ISO protein:decreased expression:blood serum (human)
protein:increased expression:blood serum (human)
protein:increased expression:blood plasma (human) 		RGD PMID:16915581 PMID:15064918 PMID:2243892 RGD:401959377, RGD:401959381, RGD:401960099 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prmt6 protein arginine methyltransferase 6 ISO mRNA:decreased expression:nucleus accumbens (human) RGD PMID:27506785 RGD:11561325 NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648 		JBrowse link
G Rabep2 rabaptin, RAB GTPase binding effector protein 2 IEP protein:increased expression:brain RGD PMID:9789813 RGD:405255653 NCBI chr 1:181,010,305...181,026,651
Ensembl chr 1:181,010,305...181,026,648 		JBrowse link
G Sirt1 sirtuin 1 IEP protein:increased expression:brain, nucleus accumbens (rat) RGD PMID:27664298 RGD:401900166 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 treatment IEP RGD PMID:27664298 RGD:401900166 NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Smad3 SMAD family member 3 ameliorates IMP RGD PMID:27422367 PMID:26030849 RGD:597830063, RGD:597830060 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smarca4 SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 ameliorates IMP RGD PMID:27422367 RGD:597830063 NCBI chr 8:28,438,370...28,535,071
Ensembl chr 8:20,167,717...20,258,975 		JBrowse link
G Srcin1 SRC kinase signaling inhibitor 1 ameliorates ISO
IMP 		RGD PMID:27506785 PMID:27506785 RGD:11561325, RGD:11561325 NCBI chr10:82,502,911...82,569,882
Ensembl chr10:82,504,393...82,571,040 		JBrowse link
G Tacr3 tachykinin receptor 3 susceptibility ISO DNA:SNPs: : RGD PMID:18422838 RGD:598092482 NCBI chr 2:223,266,536...223,363,791
Ensembl chr 2:223,266,536...223,363,791 		JBrowse link
G Tenm3 teneurin transmembrane protein 3 susceptibility ISO DNA:SNP:: (rs1514483) (human) RGD PMID:18438686 RGD:401851917 NCBI chr16:41,251,909...43,978,594
Ensembl chr16:41,252,182...43,978,594 		JBrowse link
G Tph2 tryptophan hydroxylase 2 treatment ISO DNA:SNP: :rs4290270 RGD PMID:22925276 RGD:597805898 NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19145
    Chemically-Induced Disorders 1484
      substance-related disorder 824
        Cocaine-Related Disorders 169
          cocaine abuse 34
          cocaine dependence 51
Path 2
Term Annotations click to browse term
  disease 19145
    disease of anatomical entity 18457
      nervous system disease 14363
        central nervous system disease 12646
          brain disease 11866
            disease of mental health 8477
              substance-related disorder 824
                Cocaine-Related Disorders 169
                  cocaine abuse 34
                  cocaine dependence 51
paths to the root