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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Polyuria
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Accession:DOID:9005274 term browser browse the term
Definition:Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABETES INSIPIDUS).
Synonyms:exact_synonym: Polyurias
 primary_id: MESH:D011141


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Polyuria term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP2 aquaporin 2 ISO protein:decreased expression:total kidney membrane fraction (rat) RGD PMID:10919858 RGD:2314654 NCBI chr12:49,950,737...49,958,878
Ensembl chr12:49,950,737...49,958,878 		JBrowse link
G AVP arginine vasopressin EXP
ISO		 CTD Direct Evidence: therapeutic CTD
RGD		 PMID:11012637 PMID:10919858 RGD:2314654 NCBI chr20:3,082,556...3,084,724
Ensembl chr20:3,082,556...3,084,724 		JBrowse link
G LEP leptin EXP CTD Direct Evidence: marker/mechanism CTD PMID:25086370 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G OXT oxytocin/neurophysin I prepropeptide EXP CTD Direct Evidence: marker/mechanism CTD PMID:20649851 NCBI chr20:3,071,620...3,072,517
Ensembl chr20:3,071,620...3,072,517 		JBrowse link
G PRKCA protein kinase C alpha EXP CTD Direct Evidence: marker/mechanism CTD PMID:25006961 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743 		JBrowse link
G PTGES prostaglandin E synthase EXP CTD Direct Evidence: marker/mechanism CTD PMID:19692487 NCBI chr 9:129,738,349...129,753,042
Ensembl chr 9:129,738,331...129,753,042 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 ISO RGD PMID:20323028 RGD:1354701 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 97544
    Pathological Conditions, Signs and Symptoms 53728
      Signs and Symptoms 35215
        Urological Manifestations 734
          Polyuria 7
            Hyperphosphatemia, Polyuria, and Seizures 0
Path 2
Term Annotations click to browse term
  disease 97544
    disease of anatomical entity 91158
      Urogenital Diseases 13095
        urinary system disease 4322
          Urination Disorders 696
            Polyuria 7
              Hyperphosphatemia, Polyuria, and Seizures 0
paths to the root