RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Drug Eruptions
Accession: DOID:9005236
browse the term
Definition: Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.
Synonyms: exact_synonym: Dermatitis Medicamentosa; Dermatitis, Adverse Drug Reaction; Drug Eruption; Maculopapular Drug Eruption; Maculopapular Drug Eruptions; Maculopapular Exanthem; Maculopapular Exanthems; Morbilliform Drug Reaction; Morbilliform Drug Reactions; Morbilliform Exanthem; Morbilliform Exanthems
primary_id: MESH:D003875
G
Alox5
arachidonate 5-lipoxygenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16502481
NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:149,531,515...149,578,743
G
Apoa1
apolipoprotein A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21055120
NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035
G
Apoc2
apolipoprotein C2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21055120
NCBI chr 1:88,457,397...88,462,365
Ensembl chr 1:79,329,428...79,334,476
G
Apoc3
apolipoprotein C3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21055120
NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:46,531,478...46,533,583
G
Bdnf
brain-derived neurotrophic factor
ISO
mRNA:increased expression:lymph node, ear:
RGD
PMID:19904815
RGD:8657071
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
G
C4b
complement C4B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21055120
NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,197,366...4,211,681
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19351467
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
susceptibility treatment
ISO
DNA:SNP: :Rs4244285(human) associated with tuberculosis; DNA.polymorphism, haplotype:cds:p.W212X (human)
RGD
PMID:23551241 PMID:20941486
RGD:11352742 , RGD:124713543
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19351467
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
G
Fcer1a
Fc epsilon receptor Ia
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16502481
NCBI chr13:88,218,427...88,224,723
Ensembl chr13:85,686,092...85,692,351
G
Ifng
interferon gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31150805
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
G
Il17a
interleukin 17A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31150805
NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889
G
Il18
interleukin 18
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18204966
NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887
G
Il2
interleukin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31150805
NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566
G
Il4
interleukin 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19351467
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
G
Kng1
kininogen 1
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:1371395 PMID:3034372
NCBI chr11:91,317,354...91,340,148
Ensembl chr11:77,812,752...77,835,555
G
Mpo
myeloperoxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18204966
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
G
Mthfr
methylenetetrahydrofolate reductase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14723717
NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797
G
Rela
RELA proto-oncogene, NF-kB subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31150805
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
G
RT1-Ba
RT1 class II, locus Ba
susceptibility
ISO
DNA:polymorphisms:exon:
RGD
PMID:16836882
RGD:8547665
NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,575,134...4,579,744
G
RT1-Bb
RT1 class II, locus Bb
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16502481
NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,596,559...4,607,597
G
RT1-Hb-ps1
RT1 class II, locus Hb, pseudogene 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16502481
NCBI chr20:4,777,494...4,781,486
Ensembl chr20:4,774,650...4,780,618
G
Tac1
tachykinin, precursor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1371395
NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178
G
Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31150805
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Ttr
transthyretin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21055120
NCBI chr18:12,216,684...12,225,972
Ensembl chr18:11,943,789...11,951,008
G
C1qa
complement C1q A chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:149,133,636...149,136,534
G
C1qb
complement C1q B chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr 5:154,402,276...154,407,827
Ensembl chr 5:149,118,846...149,124,407
G
C1qc
complement C1q C chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:149,127,415...149,131,017
G
Cfhr1
complement factor H-related 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr13:53,946,298...53,961,282
Ensembl chr13:51,369,211...51,410,592
G
Crp
C-reactive protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178
G
Hspa1l
heat shock protein family A (Hsp70) member 1 like
ISO
DNA:polymorphism, haplotype: :p.M493T (human)
RGD
PMID:15024131
RGD:8662461
NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,848,843...3,855,571
G
Il1b
interleukin 1 beta
ISO
DNA:SNP:promoter:-511C>T (rs 16944) (human)
RGD
PMID:23461376
RGD:11051970
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
G
Il1rn
interleukin 1 receptor antagonist
ISO
DNA:SNP:intron:rs2234663 (human)
RGD
PMID:23461376
RGD:11051970
NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445
G
Lbp
lipopolysaccharide binding protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:146,954,015...146,981,586
G
Lrg1
leucine-rich alpha-2-glycoprotein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr 9:1,034,691...1,036,937
Ensembl chr 9:947,516...949,813
G
Orm1
orosomucoid 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr 5:81,788,509...81,791,661
Ensembl chr 5:76,772,941...76,776,154
G
Vwf
von Willebrand factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:158,360,152...158,491,539
G
C3
complement C3
ISO
associated with Leprosy
RGD
PMID:2783924
RGD:7421527
NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429
G
Cfb
complement factor B
ISO
associated with Leprosy
RGD
PMID:2783924
RGD:7421527
NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,951,474...3,976,505
G
Gstm1
glutathione S-transferase mu 1
susceptibility
ISO
associated with Behcet Syndrome;DNA:deletion:: (human)
RGD
PMID:22766250
RGD:7794848
NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411
G
Lta
lymphotoxin alpha
ISO
associated with Sarcoidosis;DNA:polymorphism:intron
RGD
PMID:19225544
RGD:8548773
NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,618,853...3,620,859
G
RT1-CE13
RT1 class I, locus CE13
ISO
associated with Inflammatory Bowel Diseases; DNA:polymorphisms:cds:multiple (human)
RGD
PMID:12198697
RGD:7364926
NCBI chr20:3,314,491...3,322,815
G
Tnf
tumor necrosis factor
susceptibility
ISO
associated with Inflammatory Bowel Diseases;DNA:polymorphisms: :-1031T>C(human)
RGD
PMID:12198697
RGD:7364926
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Vdr
vitamin D receptor
susceptibility
ISO
associated with Behcet Syndrome;DNA:polymorphism: : rs7975232(human)
RGD
PMID:24880677
RGD:13217417
NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677
G
Kdr
kinase insert domain receptor
treatment
ISO
DNA:polymorphism:cds:p.H472Q(human)
RGD
PMID:20630084
RGD:8552374
NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018
G
Psmb8
proteasome 20S subunit beta 8
ISO
ClinVar Annotator: match by term: Nodular erythema digital changes
ClinVar
PMID:20159315 PMID:20534754 PMID:21129723 PMID:21953331 PMID:25741868 PMID:26524591 PMID:28492532 More...
NCBI chr20:4,654,068...4,657,049
Ensembl chr20:4,652,159...4,655,283
G
Alb
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:350256 PMID:9380243
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
G
Alb
albumin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12239465
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
G
Apcs
amyloid P component, serum
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr13:87,905,532...87,906,508
Ensembl chr13:85,373,220...85,374,298
G
C1qa
complement C1q A chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:149,133,636...149,136,534
G
C1qc
complement C1q C chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:149,127,415...149,131,017
G
Cav1
caveolin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705
G
Celf2
CUGBP, Elav-like family member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr17:75,813,928...76,639,300
Ensembl chr17:71,210,853...71,728,333
G
Cfhr1
complement factor H-related 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr13:53,946,298...53,961,282
Ensembl chr13:51,369,211...51,410,592
G
Cfp
complement factor properdin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr X:3,715,551...3,721,113
Ensembl chr X:1,161,979...1,167,573
G
Clu
clusterin
ISO
mRNA:decreased expression:conjunctiva
RGD
PMID:12036968
RGD:8699507
NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315
G
Cops5
COP9 signalosome subunit 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 5:13,975,198...13,993,391
Ensembl chr 5:9,192,100...9,210,731
G
Crp
C-reactive protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178
G
Csf3
colony stimulating factor 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11321886
NCBI chr10:84,157,485...84,159,860
Ensembl chr10:83,661,207...83,663,603
G
Ctnnb1
catenin beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
G
Cul1
cullin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 4:77,551,781...77,634,210
Ensembl chr 4:76,551,983...76,627,980
G
Cul4a
cullin 4A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr16:83,086,688...83,124,503
Ensembl chr16:76,384,546...76,422,330
G
Derl1
derlin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 7:91,293,963...91,316,639
Ensembl chr 7:89,404,417...89,427,145
G
Elmo1
engulfment and cell motility 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr17:48,982,188...49,518,525
Ensembl chr17:44,286,485...44,822,788
G
Ep300
E1A binding protein p300
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
G
Fbxo6
F-box protein 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 5:158,576,729...158,582,520
Ensembl chr 5:158,576,759...158,582,525
G
Gstm1
glutathione S-transferase mu 1
ISO
RGD
PMID:28689274
RGD:14700974
NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411
G
Ifng
interferon gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
G
Lbp
lipopolysaccharide binding protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:146,954,015...146,981,586
G
Lrg1
leucine-rich alpha-2-glycoprotein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr 9:1,034,691...1,036,937
Ensembl chr 9:947,516...949,813
G
Mif
macrophage migration inhibitory factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9372356
NCBI chr20:12,767,138...12,791,222
Ensembl chr20:12,790,902...12,799,504 Ensembl chr 4:12,790,902...12,799,504
G
Mir18a
microRNA 18a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr15:98,587,984...98,588,079
Ensembl chr15:92,180,765...92,180,860
G
Nedd4
NEDD4 E3 ubiquitin protein ligase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 8:82,264,751...82,349,642
Ensembl chr 8:73,383,695...73,468,951
G
Nfkbiz
NFKB inhibitor zeta
ISS
MouseDO
NCBI chr11:58,251,720...58,279,767
Ensembl chr11:44,782,676...44,810,723
G
Nos2
nitric oxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10620138
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
G
Nucb1
nucleobindin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 1:105,104,793...105,135,730
Ensembl chr 1:95,968,326...96,003,220
G
Orm1
orosomucoid 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr 5:81,788,509...81,791,661
Ensembl chr 5:76,772,941...76,776,154
G
Parp1
poly (ADP-ribose) polymerase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
G
Pml
PML nuclear body scaffold
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 8:67,523,164...67,557,801
Ensembl chr 8:58,628,837...58,658,971
G
Pros1
protein S
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr11:13,676,310...13,757,858
Ensembl chr11:230,696...311,286
G
Psmc5
proteasome 26S subunit, ATPase 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135
G
Ptger3
prostaglandin E receptor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21966456
NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:246,606,183...246,684,434
G
Ptgis
prostaglandin I2 synthase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:155,916,412...155,965,451
G
Rb1
RB transcriptional corepressor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
G
Rbx1
ring-box 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:112,990,835...113,001,051
G
RT1-Bb
RT1 class II, locus Bb
susceptibility
ISO
DNA:polymorphism:cds:HLA-DQB1*0601 (human)
RGD
PMID:8841298
RGD:7483570
NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,596,559...4,607,597
G
RT1-CE13
RT1 class I, locus CE13
susceptibility
ISO
DNA:polymorphisms:cds:HLA-B*5801 (human, Japanese) DNA:polymorphisms:cds:HLA-B*15:02, HLA-B*40:01, HLA-B*58:02 (human)
RGD
PMID:19018717 PMID:23692434
RGD:7364874 , RGD:7365090
NCBI chr20:3,314,491...3,322,815
G
RT1-CE16
RT1 class I, locus CE16
susceptibility
ISO
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Hypersensitivity syndrome, carbamazepine-induced, susceptibility to
CTD OMIM ClinVar
PMID:16538176 PMID:21428769 PMID:23588310
NCBI chr20:3,261,656...3,265,548
Ensembl chr20:3,257,123...3,279,563
G
Tnf
tumor necrosis factor
ISO
protein:increased expression:blister:
RGD
PMID:9852250
RGD:7401184
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Vcp
valosin-containing protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25811541
NCBI chr 5:62,005,984...62,025,387
Ensembl chr 5:57,210,168...57,229,571
G
Vwf
von Willebrand factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34142820
NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:158,360,152...158,491,539
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all