RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
G
Ccl2
C-C motif chemokine ligand 2
ISO IEP
protein:increased expression:medulla oblongata, dorsal horn of spinal cord (mouse) protein:increased expression:ipsilateral side, dorsal root ganglion (rat)
RGD
PMID:22721162 PMID:15041200
RGD:8548831 , RGD:8548884
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
G
Ep300
E1A binding protein p300
treatment
IMP IEP
mRNA:increased expression:lumbar spinal cord (rat)
RGD
PMID:23176208 PMID:23176208
RGD:7327202 , RGD:7327202
NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
G
Hmgb1
high mobility group box 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27474498
NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
G
Thbd
thrombomodulin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:27474498
NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:135,862,835...135,867,193
G
Tlr4
toll-like receptor 4
treatment
ISO
RGD
PMID:18615568
RGD:7815041
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
G
Tnf
tumor necrosis factor
ISO IMP
protein:increased expression:Schwann cell
RGD
PMID:11376190 PMID:18394803 PMID:9514564 PMID:10825476
RGD:7394735 , RGD:7394739 , RGD:7394740 , RGD:7394741
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all