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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Painful Neuropathy
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Accession:DOID:9004974 term browser browse the term
Synonyms:primary_id: MESH:C564945
 alt_id: MIM:256870



show annotations for term's descendants           Sort by:
Painful Neuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 ISO
IEP
protein:increased expression:medulla oblongata, dorsal horn of spinal cord (mouse)
protein:increased expression:ipsilateral side, dorsal root ganglion (rat)
RGD PMID:22721162 PMID:15041200 RGD:8548831, RGD:8548884 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ep300 E1A binding protein p300 treatment IMP
IEP
mRNA:increased expression:lumbar spinal cord (rat) RGD PMID:23176208 PMID:23176208 RGD:7327202, RGD:7327202 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Hmgb1 high mobility group box 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27474498 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565
JBrowse link
G Thbd thrombomodulin ISO CTD Direct Evidence: therapeutic CTD PMID:27474498 NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:135,862,835...135,867,193
JBrowse link
G Tlr4 toll-like receptor 4 treatment ISO RGD PMID:18615568 RGD:7815041 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor ISO
IMP
protein:increased expression:Schwann cell RGD PMID:11376190 PMID:18394803 PMID:9514564 PMID:10825476 RGD:7394735, RGD:7394739, RGD:7394740, RGD:7394741 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19140
    disease of anatomical entity 18453
      nervous system disease 14363
        peripheral nervous system disease 4397
          neuropathy 4185
            Painful Neuropathy 6
paths to the root