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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Thymus Hyperplasia
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Accession:DOID:9004911 term browser browse the term
Definition:Enlargement of the thymus. A condition described in the late 1940's and 1950's as pathological thymic hypertrophy was status thymolymphaticus and was treated with radiotherapy. Unnecessary removal of the thymus was also practiced. It later became apparent that the thymus undergoes normal physiological hypertrophy, reaching a maximum at puberty and involuting thereafter. The concept of status thymolymphaticus has been abandoned. Thymus hyperplasia is present in two thirds of all patients with myasthenia gravis. (From Segen, Dictionary of Modern Medicine, 1992; Cecil Textbook of Medicine, 19th ed, p1486)
Synonyms:exact_synonym: Hyperplasia of Thymus Gland;   Thymic Hyperplasia;   Thymic Hyperplasias;   Thymus Gland Hyperplasia;   Thymus Gland Hyperplasias
 primary_id: MESH:D013952
 xref: EFO:1001860


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Thymus Hyperplasia term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxn1 forkhead box N1 IMP RGD PMID:26931321 RGD:11568681 NCBI chr10:63,251,400...63,273,710
Ensembl chr10:63,251,400...63,273,710 		JBrowse link
G Foxn1em1Nips forkhead box N1; CRISPR/Cas9 system induced mutant 1, National Institute for Physiological Sciences IMP RGD PMID:26931321 RGD:11568681
G Foxn1em2Nips forkhead box N1; CRISPR/Cas9 system induced mutant 2, National Institute for Physiological Sciences IMP RGD PMID:26931321 RGD:11568681
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19050
    disease of anatomical entity 18384
      endocrine system disease 6887
        thymus gland disease 27
          Thymus Hyperplasia 10
Path 2
Term Annotations click to browse term
  disease 19050
    disease of anatomical entity 18384
      Immune & Inflammatory Diseases 5742
        immune system disease 4930
          lymphatic system disease 1749
            thymus gland disease 27
              Thymus Hyperplasia 10
paths to the root