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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Vascular Remodeling
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Accession:DOID:9004771 term browser browse the term
Definition:The active alterations of vascular wall structures, often leading to elevated VASCULAR RESISTANCE. It is associated with AGING; ATHEROSCLEROSIS; DIABETES MELLITUS; HYPERTENSION; PREGNANCY; PULMONARY HYPERTENSION; and STROKE, but is also a normal part of EMBRYOGENESIS.
Synonyms:exact_synonym: Pulmonary Arterial Remodeling;   Pulmonary Arterial Remodelings;   Vascular Remodelings
 primary_id: MESH:D066253


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Vascular Remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVRL1 activin A receptor like type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26540443 NCBI chr27:3,075,373...3,090,549
Ensembl chr27:3,076,124...3,092,469 		JBrowse link
G AGT angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:25259750 PMID:27678262 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G BMPR2 bone morphogenetic protein receptor type 2 ISO RGD PMID:25593290 RGD:38500244 NCBI chr37:11,342,292...11,540,199
Ensembl chr37:11,342,384...11,533,024 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27678262 NCBI chr37:24,831,351...24,846,387
Ensembl chr37:24,843,171...24,844,247 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 treatment ISO RGD PMID:21294880 RGD:6480473 NCBI chr19:38,874,650...38,877,740
Ensembl chr19:38,874,145...38,877,740 		JBrowse link
G EGFR epidermal growth factor receptor treatment ISO RGD PMID:31264901 RGD:38599217 NCBI chr18:5,983,669...6,044,092
Ensembl chr18:5,982,770...6,042,631 		JBrowse link
G GATA2 GATA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr20:2,472,251...2,488,380
Ensembl chr20:2,473,912...2,480,991 		JBrowse link
G GJA1 gap junction protein alpha 1 ISO CTD Direct Evidence: therapeutic CTD PMID:36720419 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936 		JBrowse link
G MIR125A microRNA mir-125a treatment ISO RGD PMID:29700287 RGD:26884455 NCBI chr 1:105,400,273...105,400,332
Ensembl chr 1:105,400,270...105,400,337 		JBrowse link
G SENP1 SUMO specific peptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr27:6,664,750...6,719,257
Ensembl chr27:6,664,818...6,714,479 		JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO RGD PMID:26856544 RGD:11073690 NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301 		JBrowse link
G TWIST1 twist family bHLH transcription factor 1 ISO protein:increased expression:lung RGD PMID:25593290 RGD:38500244
G VIM vimentin ISO protein:increased phosphorylation:lung RGD PMID:25593290 RGD:38500244 NCBI chr 2:19,671,316...19,679,367
Ensembl chr 2:19,671,316...19,679,466 		JBrowse link
Aortic Remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ETV2 ETS variant transcription factor 2 ameliorates ISO RGD PMID:29191922 RGD:156451665 NCBI chr 1:116,971,238...116,974,831
Ensembl chr 1:116,971,365...116,985,796 		JBrowse link
G IFNB1 interferon beta 1 ameliorates ISO RGD PMID:17466308 RGD:401854230 NCBI chr11:40,668,295...40,668,855
Ensembl chr11:40,668,295...40,668,855 		JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO associated with Hypertension RGD PMID:26693246 RGD:11073698 NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15721
    Pathological Conditions, Signs and Symptoms 12300
      Anatomical Pathological Conditions 2585
        Vascular Remodeling 15
          Aortic Remodeling 3
paths to the root