RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Neoplasm Invasiveness
Accession: DOID:9004575
browse the term
Definition: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Synonyms: exact_synonym: CANCER PROGRESSION; CANCER PROGRESSION AND TUMOR CELL MOTILITY; Neoplasm Invasion; TUMOR CELL MOTILITY
primary_id: MESH:D009361
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Aco1
aconitase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20390345
NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
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Actb
actin, beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15654357
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23289900
NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
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Ahnak
AHNAK nucleoprotein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20388789
NCBI chr 1:205,882,225...205,970,934
Ensembl chr 1:205,882,273...205,970,926
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Ahr
aryl hydrocarbon receptor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:25826687 PMID:27752740
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Akr1b10
aldo-keto reductase family 1 member B10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25686905
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Aldoa
aldolase, fructose-bisphosphate A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15654357
NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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Alkbh8
alkB homolog 8, tRNA methyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27811057
NCBI chr 6:378,779...449,382
Ensembl chr 6:378,100...452,165
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Alox5
arachidonate 5-lipoxygenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20061081
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Ambp
alpha-1-microglobulin/bikunin precursor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:14644129
NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331
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Amotl1
angiomotin-like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34480788
NCBI chr 8:11,348,651...11,467,564
Ensembl chr 8:11,353,674...11,467,573
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Angpt1
angiopoietin 1
IEP
associated with Mammary Neoplasms, Animal;mRNA:increased expression:mammary gland
RGD
PMID:15459484
RGD:1626167
NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
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Angptl4
angiopoietin-like 4
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17130448
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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Anxa1
annexin A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15654357
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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Anxa2
annexin A2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15654357
NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
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Arf1
ADP-ribosylation factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27517156
NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434
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Axl
Axl receptor tyrosine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26206560
NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265
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Bcar1
BCAR1 scaffold protein, Cas family member
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21291860
NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907
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Brms1
BRMS1, transcriptional repressor and anoikis regulator
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:27501413
NCBI chr 1:202,345,766...202,355,028
Ensembl chr 1:202,345,704...202,355,028
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Bsg
basigin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21165561
NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387
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Calr
calreticulin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15048980
NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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Calu
calumenin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15048980
NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593
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Cat
catalase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21749277 PMID:22580338
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25199511 PMID:32512068
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl3
C-C motif chemokine ligand 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:36346222
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Ccl5
C-C motif chemokine ligand 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18985009
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Cd82
Cd82 molecule
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20075392
NCBI chr 3:79,387,361...79,431,847
Ensembl chr 3:79,385,887...79,431,809
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Cdh1
cadherin 1
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:19839049 PMID:22580338
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdh2
cadherin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27811057
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24495407
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Cfl1
cofilin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15048980
NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
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Chi3l1
chitinase 3 like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21029458
NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787
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Chrna7
cholinergic receptor nicotinic alpha 7 subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18844224
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
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Cse1l
chromosome segregation 1 like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34022224
NCBI chr 3:155,641,104...155,678,866
Ensembl chr 3:155,641,166...155,678,865
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Cstb
cystatin B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19747051 PMID:22287159
NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526
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Ctbp2
C-terminal binding protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28414304
NCBI chr 1:187,782,064...187,918,115
Ensembl chr 1:187,782,682...187,920,222
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Ctnnb1
catenin beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23707762 PMID:26990689
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Ctsb
cathepsin B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19700239 PMID:19747051
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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Ctsd
cathepsin D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15048980
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Ctss
cathepsin S
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19700239
NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
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Ctu1
cytosolic thiouridylase subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27811057
NCBI chr 1:94,115,431...94,121,224
Ensembl chr 1:94,115,420...94,121,221
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Ctu2
cytosolic thiouridylase subunit 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27811057
NCBI chr19:50,539,184...50,544,629
Ensembl chr19:50,539,352...50,544,623
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Cxcl12
C-X-C motif chemokine ligand 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19700239 PMID:25231984 PMID:25753200
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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Cxcr4
C-X-C motif chemokine receptor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25753200
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26213588
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Dek
DEK proto-oncogene
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21291860 PMID:27811057
NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
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Dlx4
distal-less homeobox 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26213588
NCBI chr10:80,085,037...80,090,434
Ensembl chr10:80,085,465...80,090,456
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Dmd
dystrophin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24793134
NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207
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Dnmt1
DNA methyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28544374
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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Ednrb
endothelin receptor type B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26213588
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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Eef2
eukaryotic translation elongation factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21554491
NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
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Egf
epidermal growth factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15802018 PMID:22869556 PMID:23064031 PMID:24587105 PMID:27634460
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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Egfr
epidermal growth factor receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18844224 PMID:23867902
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Eif4e
eukaryotic translation initiation factor 4E
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20388789
NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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Elp1
elongator acetyltransferase complex subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27811057
NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762
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Elp3
elongator acetyltransferase complex subunit 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27811057
NCBI chr15:39,754,635...39,816,482
Ensembl chr15:39,754,632...39,816,445
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En1
engrailed homeobox 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26213588
NCBI chr13:31,750,892...31,756,477
Ensembl chr13:31,751,545...31,755,943
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Eno1
enolase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15654357
NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
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Epas1
endothelial PAS domain protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26735578 PMID:30090327
NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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Epo
erythropoietin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16699298
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Epor
erythropoietin receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16699298
NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
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Eps8
EGFR pathway substrate 8, signaling adaptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19799886
NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873
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Esr1
estrogen receptor 1
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:26990689 PMID:27366082 PMID:35044086
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Fam83a
family with sequence similarity 83, member A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34931434
NCBI chr 7:89,522,826...89,547,284
Ensembl chr 7:89,522,826...89,547,388
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Fgfr4
fibroblast growth factor receptor 4
ISO
ClinVar Annotator: match by term: Cancer progression and tumor cell motility
ClinVar
PMID:11830541 PMID:25741868 PMID:26675719 PMID:33116287
NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242
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Fn1
fibronectin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24014025
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Foxp1
forkhead box P1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25485836
NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258
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Fth1
ferritin heavy chain 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20390345
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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Ftl1
ferritin light chain 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20390345
NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725
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Gab2
GRB2-associated binding protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21996746
NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031
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Grep1
glycine rich extracellular protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34652879
NCBI chr10:12,727,164...12,748,629
Ensembl chr10:12,727,166...12,741,819
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H19
H19 imprinted maternally expressed transcript
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28544374
NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
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Hdac3
histone deacetylase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34973135
NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
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Hgf
hepatocyte growth factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9932610 PMID:15654357
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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Hif1a
hypoxia inducible factor 1 subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12811834 PMID:29501572
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Hmga2
high mobility group AT-hook 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28830677
NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
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Hmgcs2
3-hydroxy-3-methylglutaryl-CoA synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27816970
NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
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Hmox1
heme oxygenase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24211270
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hoxb13
homeo box B13
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26213588
NCBI chr10:81,160,498...81,162,777
Ensembl chr10:81,160,498...81,162,777
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Hoxb3
homeo box B3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34652879
NCBI chr10:81,258,739...81,314,134
Ensembl chr10:81,299,357...81,313,107
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Hpse
heparanase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22240343
NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010
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Hras
HRas proto-oncogene, GTPase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23877152
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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Id4
inhibitor of DNA binding 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14633621
NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470
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Igf1
insulin-like growth factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18398872
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27567548
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il1rn
interleukin 1 receptor antagonist
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:27567548
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Il6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26101800 PMID:26284488
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Ins2
insulin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24587105
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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Ireb2
iron responsive element binding protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20390345
NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611
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Itga5
integrin subunit alpha 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21224397
NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
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Itgb1
integrin subunit beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21224397
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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Itpk1
inositol-tetrakisphosphate 1-kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26213588
NCBI chr 6:121,710,750...121,844,501
Ensembl chr 6:121,710,755...121,844,107
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Kcnd2
potassium voltage-gated channel subfamily D member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34418280
NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
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Kdm1a
lysine demethylase 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22493729
NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319
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Krt19
keratin 19
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15048980
NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
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Krt7
keratin 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19921857
NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052
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Ldhb
lactate dehydrogenase B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15048980
NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
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Lef1
lymphoid enhancer binding factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27811057
NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
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Lin28a
lin-28 homolog A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26910839
NCBI chr 5:146,227,119...146,244,122
Ensembl chr 5:146,227,119...146,244,122
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Loxl2
lysyl oxidase-like 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24014025
NCBI chr15:44,683,449...44,773,067
Ensembl chr15:44,683,880...44,773,067
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Mapk1
mitogen activated protein kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22580338
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22580338
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Met
MET proto-oncogene, receptor tyrosine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15654357
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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Mir141
microRNA 141
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:27616325
NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332
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Mir155
microRNA 155
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28315615
NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
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Mir186
microRNA 186
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34291859
NCBI chr 2:246,582,806...246,582,891
Ensembl chr 2:246,582,806...246,582,891
G
Mir191
microRNA 191
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29277653
NCBI chr 8:109,264,098...109,264,188
G
Mir200b
microRNA 200b
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:19839049
NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366
G
Mir200c
microRNA 200c
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:19839049
NCBI chr 4:157,523,679...157,523,747
G
Mir21
microRNA 21
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26101800 PMID:29501572
NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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Mir217
microRNA 217
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25538231
NCBI chr14:102,531,505...102,531,609
Ensembl chr14:102,531,505...102,531,609
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Mir346
microRNA 346
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27501413 PMID:27777383
NCBI chr16:10,218,118...10,218,215
Ensembl chr16:10,218,118...10,218,215
G
Mir497
microRNA 497
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:35066776
NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584
G
Mir532
microRNA 532
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30639441
NCBI chr X:15,247,315...15,247,393
Ensembl chr X:15,247,315...15,247,393
G
Mir708
microRNA 708
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:34652879
NCBI chr 1:150,599,876...150,599,963
Ensembl chr 1:150,599,876...150,599,963
G
Mir874
microRNA 874
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:30004169
NCBI chr17:6,620,649...6,620,724
Ensembl chr17:6,620,649...6,620,724
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Mmp1
matrix metallopeptidase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22580338
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp14
matrix metallopeptidase 14
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24014025
NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
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Mmp2
matrix metallopeptidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18398872 PMID:19770485 PMID:22321834 PMID:23707804 PMID:34278709
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp3
matrix metallopeptidase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20188714 PMID:26284488
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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Mmp9
matrix metallopeptidase 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19617202 PMID:19700239 PMID:20188714 PMID:21187089 PMID:22503731 PMID:23867902 PMID:24333868 More...
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mt2A
metallothionein 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21187089
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
G
Mt3
metallothionein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23794209
NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
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Mtdh
metadherin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29315995
NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413
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Myd88
MYD88, innate immune signal transduction adaptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21473897
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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Myh9
myosin, heavy chain 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28650484
NCBI chr 7:109,343,718...109,424,457
Ensembl chr 7:109,343,706...109,424,457
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Mylk
myosin light chain kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10232591 PMID:12970723
NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
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Ncam1
neural cell adhesion molecule 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19700239
NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
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Nek2
NIMA-related kinase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28509438
NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051
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Nfe2l2
NFE2 like bZIP transcription factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32682831
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nme1
NME/NM23 nucleoside diphosphate kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15048980
NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408
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Notch2
notch receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30670679
NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
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Nrg1
neuregulin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19617202
NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
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Nuak1
NUAK family kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26213588 PMID:26873845
NCBI chr 7:19,330,034...19,401,918
Ensembl chr 7:19,329,933...19,401,913
G
Pak1
p21 (RAC1) activated kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:35066776
NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383
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Pax6
paired box 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26213588
NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
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Pdcd4
programmed cell death 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23272133
NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
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Pip5k1a
phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34755307
NCBI chr 2:182,628,299...182,671,584
Ensembl chr 2:182,628,300...182,671,598
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Pkm
pyruvate kinase M1/2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15048980 PMID:15654357
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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Plau
plasminogen activator, urokinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14644129 PMID:26284488
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
G
Plaur
plasminogen activator, urokinase receptor
IDA ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:22261521 PMID:12198772
RGD:729319
NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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Ppp1r12b
protein phosphatase 1, regulatory subunit 12B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28650484
NCBI chr13:46,199,418...46,397,108
Ensembl chr13:46,201,251...46,397,108
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Prdx2
peroxiredoxin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23911960
NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
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Pten
phosphatase and tensin homolog
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21994956
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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Ptk2
protein tyrosine kinase 2
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:12811834 PMID:25199511
NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
G
Pvt1
Pvt1 oncogene
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:35213076
NCBI chr 7:93,656,528...93,879,938
G
Rab27a
RAB27A, member RAS oncogene family
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34291859
NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829
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Rab27b
RAB27B, member RAS oncogene family
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34291859
NCBI chr18:63,597,554...63,794,124
Ensembl chr18:63,600,937...63,757,180
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Rasal2
RAS protein activator like 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34826200
NCBI chr13:69,279,882...69,569,161
Ensembl chr13:69,258,622...69,569,940
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Rbm38
RNA binding motif protein 38
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:34453780
NCBI chr 3:161,801,577...161,814,381
Ensembl chr 3:161,801,577...161,814,381
G
Reck
reversion-inducing-cysteine-rich protein with kazal motifs
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20127710
NCBI chr 5:58,102,961...58,169,516
Ensembl chr 5:58,102,981...58,169,502
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Rela
RELA proto-oncogene, NF-kB subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19896475 PMID:29501572
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Rhoa
ras homolog family member A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19896475
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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Rnf207
ring finger protein 207
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26213588
NCBI chr 5:162,815,351...162,828,325
Ensembl chr 5:162,815,357...162,828,375
G
Rpl3l
ribosomal protein L3-like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26213588
NCBI chr10:13,753,914...13,764,458
Ensembl chr10:13,753,886...13,764,457
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Rps6ka3
ribosomal protein S6 kinase A3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21488662
NCBI chr X:35,517,306...35,623,296
Ensembl chr X:35,517,306...35,623,207
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Rpsa
ribosomal protein SA
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15048980
NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247
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S100a11
S100 calcium binding protein A11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20388789
NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044
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S100a4
S100 calcium-binding protein A4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15048980
NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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S1pr2
sphingosine-1-phosphate receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26518876
NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574
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Septin9
septin 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20388789
NCBI chr10:102,409,798...102,579,056
Ensembl chr10:102,409,711...102,579,055
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Set
Set nuclear proto-oncogene
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24555657
NCBI chr 3:13,334,564...13,345,598
Ensembl chr 3:13,335,041...13,363,567
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Slc39a10
solute carrier family 39 member 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17359283
NCBI chr 9:54,836,841...54,960,325
Ensembl chr 9:54,876,141...54,960,325
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Slc6a12
solute carrier family 6 member 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26213588
NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750
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Smpd1
sphingomyelin phosphodiesterase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24951586
NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
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Snai1
snail family transcriptional repressor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22580338 PMID:24014025
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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Snai2
snail family transcriptional repressor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22580338
NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
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Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10853026 PMID:11053990 PMID:15048980 PMID:15654357 PMID:21749277 PMID:22580338 More...
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
G
Sorl1
sortilin related receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26213588
NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
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Sox11
SRY-box transcription factor 11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26213588
NCBI chr 6:44,008,333...44,010,354
Ensembl chr 6:44,008,340...44,010,354
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Sox9
SRY-box transcription factor 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32682831
NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
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Sp1
Sp1 transcription factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26317792 PMID:35072892
NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18844224 PMID:21291860
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Stat3
signal transducer and activator of transcription 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26101800
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Sumo1
small ubiquitin-like modifier 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15048980
NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761
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Tbx15
T-box transcription factor 15
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26213588
NCBI chr 2:186,576,650...186,687,748
Ensembl chr 2:186,576,676...186,687,663
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Tf
transferrin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20390345
NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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Tfpi2
tissue factor pathway inhibitor 2
ISO
RGD
PMID:11687973
RGD:11060269
NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600
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Tgfb1
transforming growth factor, beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23992306 PMID:24727557 PMID:24793912 PMID:25884904 PMID:26896736 PMID:32745479 More...
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tgif1
TGFB-induced factor homeobox 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25791921
NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802
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Timp1
TIMP metallopeptidase inhibitor 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:1318976
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
G
Timp3
TIMP metallopeptidase inhibitor 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:23109338
NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
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Tkt
transketolase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15654357
NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
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Tln1
talin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21291860
NCBI chr 5:57,787,670...57,817,900
Ensembl chr 5:57,787,943...57,817,900
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Tlr4
toll-like receptor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21473897
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tmem139
transmembrane protein 139
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26213588
NCBI chr 4:71,147,072...71,149,151
Ensembl chr 4:71,146,724...71,167,399
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22199285 PMID:23431386 PMID:23899529 PMID:24613819
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tp53bp2
tumor protein p53 binding protein, 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28650484
NCBI chr13:94,088,769...94,145,436
Ensembl chr13:94,088,709...94,145,432
G
Trim47
tripartite motif-containing 47
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31981573
NCBI chr10:101,337,573...101,342,044
Ensembl chr10:101,337,573...101,342,044
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Trpm7
transient receptor potential cation channel, subfamily M, member 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30710498
NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190
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Twist1
twist family bHLH transcription factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22155737
NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
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Txn1
thioredoxin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15048980
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
G
Ubqln1
ubiquilin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24747970
NCBI chr17:6,439,002...6,477,096
Ensembl chr17:6,439,002...6,477,090
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Vim
vimentin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27811057
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Xpc
XPC complex subunit, DNA damage recognition and repair factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27777383
NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
G
Xrcc3
X-ray repair cross complementing 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21283680
NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444
G
Yap1
Yes1 associated transcriptional regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34351699
NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
G
Zbtb16
zinc finger and BTB domain containing 16
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26213588
NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
G
Zeb1
zinc finger E-box binding homeobox 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21954225
NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
G
Zeb2
zinc finger E-box binding homeobox 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21954225
NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157
G
Zfp36
zinc finger protein 36
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:25556371
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
G
Zfp367
zinc finger protein 367
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34351699
NCBI chr17:965,161...984,290
Ensembl chr17:965,161...984,287
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Zfr
zinc finger RNA binding protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34323000
NCBI chr 2:61,137,611...61,200,322
Ensembl chr 2:61,137,611...61,200,322
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all