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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Hyperoxic Lung Injury
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Accession:DOID:9004237 term browser browse the term
Definition:Damage to any compartment of the lung caused by an abnormal increase in the amount of oxygen.



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Hyperoxic Lung Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 treatment IDA
ISO
RGD PMID:15958656 PMID:24893714 PMID:21745492 RGD:4892072, RGD:11576306, RGD:11576318 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Elane elastase, neutrophil expressed treatment IMP RGD PMID:11104832 RGD:10450581 NCBI chr 7:10,467,877...10,469,725
Ensembl chr 7:9,817,252...9,819,100
JBrowse link
G Fgf2 fibroblast growth factor 2 IMP RGD PMID:12626345 RGD:11567262 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Hmox1 heme oxygenase 1 treatment IEP RGD PMID:23475767 RGD:10755753 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Mir21 microRNA 21 exacerbates
ameliorates
IMP
IDA
RGD PMID:28627345 PMID:31537223 RGD:41404708, RGD:41404709 NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO RGD PMID:25760549 RGD:13204816 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 ISO RGD PMID:16678022 RGD:10769360 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 ISO RGD PMID:16678022 RGD:10769360 NCBI chr17:31,114,825...31,144,062
Ensembl chr17:30,909,187...30,938,320
JBrowse link
G Pdgfb platelet derived growth factor subunit B IEP mRNA:increased expression:lung: RGD PMID:2696512 RGD:10449500 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Ptch1 patched 1 IEP mRNA, protein:increased expression:lung RGD PMID:22641469 RGD:12859031 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
JBrowse link
G Shh sonic hedgehog signaling molecule IEP mRNA, protein:increased expression:lung RGD PMID:22641469 RGD:12859031 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Xdh xanthine dehydrogenase IEP RGD PMID:2549869 RGD:13209004 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19141
    Wounds and Injuries 998
      Thoracic Injuries 308
        Lung Injury 302
          Hyperoxic Lung Injury 12
Path 2
Term Annotations click to browse term
  disease 19141
    disease of anatomical entity 18453
      respiratory system disease 5246
        lower respiratory tract disease 2359
          lung disease 2320
            Lung Injury 302
              Hyperoxic Lung Injury 12
paths to the root