RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Hyperoxic Lung Injury
Accession: DOID:9004237
browse the term
Definition: Damage to any compartment of the lung caused by an abnormal increase in the amount of oxygen.
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
treatment
IDA ISO
RGD
PMID:15958656 PMID:24893714 PMID:21745492
RGD:4892072 , RGD:11576306 , RGD:11576318
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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Elane
elastase, neutrophil expressed
treatment
IMP
RGD
PMID:11104832
RGD:10450581
NCBI chr 7:10,467,877...10,469,725
Ensembl chr 7:9,817,252...9,819,100
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Fgf2
fibroblast growth factor 2
IMP
RGD
PMID:12626345
RGD:11567262
NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221
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Hmox1
heme oxygenase 1
treatment
IEP
RGD
PMID:23475767
RGD:10755753
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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Mir21
microRNA 21
exacerbates ameliorates
IMP IDA
RGD
PMID:28627345 PMID:31537223
RGD:41404708 , RGD:41404709
NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348
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Mmp9
matrix metallopeptidase 9
treatment
ISO
RGD
PMID:25760549
RGD:13204816
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
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Nqo1
NAD(P)H quinone dehydrogenase 1
ISO
RGD
PMID:16678022
RGD:10769360
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
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Nqo2
N-ribosyldihydronicotinamide:quinone dehydrogenase 2
ISO
RGD
PMID:16678022
RGD:10769360
NCBI chr17:31,114,825...31,144,062
Ensembl chr17:30,909,187...30,938,320
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Pdgfb
platelet derived growth factor subunit B
IEP
mRNA:increased expression:lung:
RGD
PMID:2696512
RGD:10449500
NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984
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Ptch1
patched 1
IEP
mRNA, protein:increased expression:lung
RGD
PMID:22641469
RGD:12859031
NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
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Shh
sonic hedgehog signaling molecule
IEP
mRNA, protein:increased expression:lung
RGD
PMID:22641469
RGD:12859031
NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:6,954,017...6,963,170
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Xdh
xanthine dehydrogenase
IEP
RGD
PMID:2549869
RGD:13209004
NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268
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