Respiratory Tract Neoplasms - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Respiratory Tract Neoplasms	go back to main search page
Accession:	DOID:9003744	browse the term
Definition:	New abnormal growth of tissue in the RESPIRATORY SYSTEM.
Synonyms:	exact_synonym:	Respiratory Tract Neoplasm; respiratory system neoplasm
	primary_id:	MESH:D012142
	xref:	EFO:0003853

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Rat (1054) Mouse (1045) Human (15437) Chinchilla (913) Bonobo (959) Dog (1006) Squirrel (916) Pig (982) Green Monkey (942) Naked Mole-rat (900) All
Genes (1022) Strains (1) Cell Lines (31)

adenosquamous lung carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

transthyretin

protein:increased expression:lung (human)

NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008

asbestos-related lung carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ADAM metallopeptidase domain 28

associated with lung adenocarcinoma ;mRNA:increased expression:lung

RGD

NCBI chr15:43,774,463...43,840,726
Ensembl chr15:42,944,467...43,840,672

G

kinesin family member 5A

susceptibility

protein:increased expression:serum (human)

RGD

NCBI chr 7:63,051,894...63,089,024
Ensembl chr 7:63,049,424...63,092,858

G

retinoic acid receptor, beta

DNA:hypomethylation:lung

RGD

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

bronchiolo-alveolar adenocarcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ALX homeobox 4

ameliorates

RGD

NCBI chr 3:79,611,682...79,648,260
Ensembl chr 3:79,611,719...79,648,260

G

cyclin D1

protein:increased expression:lung

RGD

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

DNA methyltransferase 1

disease_progression

RGD

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

epidermal growth factor receptor

DNA:snp:cds:p.T790M (human)
DNA:mutations:exons:
protein:increased expression:tumor (human)

RGD

PMID:15737014 PMID:26059825 PMID:21419590

RGD:5131465, RGD:11075076, RGD:5131630

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

mRNA:decreased expression:tumor (human)

RGD

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

glutathione S-transferase pi 1

DNA:hypermethylation:promoter (human)

RGD

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

KRAS proto-oncogene, GTPase

DNA:mutations:cds:

RGD

NCBI chr 4:178,185,418...178,218,484

G

microRNA 130a

CTD Direct Evidence: marker/mechanism

NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629

G

microRNA 144

CTD Direct Evidence: marker/mechanism

NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430

G

microRNA 19a

CTD Direct Evidence: marker/mechanism

NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993

G

microRNA 345

CTD Direct Evidence: marker/mechanism

NCBI chr 6:127,754,027...127,754,122
Ensembl chr 6:127,754,027...127,754,122

G

microRNA 497

CTD Direct Evidence: marker/mechanism

NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584

G

tumor protein p53

DNA:mutations:exons:

RGD

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

bronchus carcinoma

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione S-transferase pi 1

mRNA:decreased expression:bronchus, epithelial cell

RGD

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

intercellular adhesion molecule 1

protein:increased secretion:lung (human)

RGD

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 10

protein:increased expression:lung

RGD

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 receptor antagonist

protein:increased expression, alternative forms:lung

RGD

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

Carney Triad

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

succinate dehydrogenase complex flavoprotein subunit A

ClinVar Annotator: match by term: Carney triad | ClinVar Annotator: match by term: GASTRIC LEIOMYOSARCOMA, PULMONARY CHONDROMA, AND EXTRAADRENAL PARAGANGLIOMA

PMID:20484225 PMID:21505157 PMID:21752896 PMID:22955521 PMID:22974104 More...

NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535

G

succinate dehydrogenase complex iron sulfur subunit B

ClinVar Annotator: match by term: GASTRIC LEIOMYOSARCOMA, PULMONARY CHONDROMA, AND EXTRAADRENAL PARAGANGLIOMA

PMID:15987702 PMID:16288654 PMID:16317055 PMID:16912137 PMID:16916404 More...

NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293

G

succinate dehydrogenase complex subunit C

ClinVar Annotator: match by term: Carney triad | ClinVar Annotator: match by term: GASTRIC LEIOMYOSARCOMA, PULMONARY CHONDROMA, AND EXTRAADRENAL PARAGANGLIOMA

PMID:9536098 PMID:12658451 PMID:17576681 PMID:17667967 PMID:17804857 More...

NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253

DICER1 syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ankyrin repeat and SOCS box-containing 2

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,474,754...122,511,014
Ensembl chr 6:122,474,756...122,510,854

G

BTB domain containing 7

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:121,920,365...122,010,114
Ensembl chr 6:121,923,023...121,972,405

G

cytochrome c oxidase subunit 8C

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,028,566...122,029,889
Ensembl chr 6:122,028,566...122,029,889

G

DEAD-box helicase 24

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,564,767...122,582,032
Ensembl chr 6:122,564,767...122,581,927

G

dicer 1 ribonuclease III

ClinVar Annotator: match by term: DICER1 syndrome

PMID:9295070 PMID:9345104 PMID:9536098 PMID:15242644 PMID:15987463 More...

NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965

G

family with sequence similarity 181, member A

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,465,373...122,471,397
Ensembl chr 6:122,465,391...122,471,397

G

goosecoid homeobox

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:123,388,072...123,390,111
Ensembl chr 6:123,388,072...123,390,111

G

interferon, alpha-inducible protein 27

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294

G

interferon, alpha-inducible protein 27 like 2A

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,598,872...122,600,358
Ensembl chr 6:122,598,872...122,600,360

G

OTU deubiquitinase, ubiquitin aldehyde binding 2

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,545,067...122,563,657
Ensembl chr 6:122,545,061...122,563,644

G

protein phosphatase 4, regulatory subunit 4

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,663,172...122,753,988
Ensembl chr 6:122,663,344...122,753,384

G

proline rich membrane anchor 1

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,338,365...122,390,955
Ensembl chr 6:122,338,370...122,389,921

G

serpin family A member 1

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339

G

serpin family A member 10

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,756,106...122,764,544
Ensembl chr 6:122,756,108...122,764,544

G

serpin family A member 11

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,903,246...122,912,695
Ensembl chr 6:122,903,250...122,912,670

G

serpin family A member 12

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,952,552...122,967,271
Ensembl chr 6:122,952,552...122,967,271

G

serpin family A member 1F

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,820,752...122,827,112
Ensembl chr 6:122,820,907...122,827,112

G

serpin family A member 3N

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

serpin family A member 4

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,999,970...123,009,083
Ensembl chr 6:122,999,900...123,009,082

G

serpin family A member 5

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:123,009,224...123,028,412
Ensembl chr 6:123,023,306...123,028,407

G

serpin family A member 6

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,780,040...122,790,274
Ensembl chr 6:122,780,043...122,790,349

G

serpin family A member 9

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,918,819...122,936,000
Ensembl chr 6:122,918,880...122,936,000

G

ubiquitin protein ligase E3 component n-recognin 7

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:121,898,613...121,918,480
Ensembl chr 6:121,898,623...121,918,477

G

unc-79 homolog, NALCN channel complex subunit

ClinVar Annotator: match by term: DICER1 syndrome

PMID:26545620 PMID:26555935 PMID:28492532

NCBI chr 6:122,082,369...122,327,641
Ensembl chr 6:122,080,308...122,327,591

glottis squamous cell carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

WD repeat containing, antisense to TP53

disease_progression

RGD

NCBI chr10:54,282,092...54,299,908
Ensembl chr10:54,282,105...54,298,929

large cell neuroendocrine carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 7 member 5

disease_progression

RGD

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

laryngeal carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

atypical chemokine receptor 3

disease_progression

protein:increased expression:larynx (human)

RGD

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237

G

C-X-C motif chemokine receptor 4

disease_progression

protein:increased expression:larynx (human)

RGD

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

lysine methyltransferase 2C

mRNA:decreased expression:larynx

RGD

NCBI chr 4:9,620,638...9,834,787
Ensembl chr 4:9,609,627...9,833,539

G

suppressor of cytokine signaling 1

severity

RGD

NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383

G

TNF receptor associated factor 6

disease_progression

RGD

NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507

G

ubiquitin protein ligase E3 component n-recognin 5

exacerbates

mRNA, protein:increased expression:larynx (human)

RGD

NCBI chr 7:69,115,216...69,224,843
Ensembl chr 7:69,116,761...69,224,903

G

X-ray repair cross complementing 1

susceptibility

DNA:missense mutation:cds: p.R280H (human)
DNA:SNPs, haplotype:: (rs3213403, rs1799778, rs3213282) (human)

RGD

PMID:27808358 PMID:24956286

RGD:151236313, RGD:151236314

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

Laryngeal Neoplasms

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

CTD Direct Evidence: marker/mechanism

NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182

G

epidermal growth factor receptor

severity

protein:increased expression:tumor (human)

RGD

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

ERCC excision repair 1, endonuclease non-catalytic subunit

susceptibility

DNA:snp:exon:c.354T>C (human) (rs11615)

RGD

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

glutathione S-transferase pi 1

protein:increased expression:larynx

RGD

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

microRNA 10a

sexual_dimorphism

miRNA:decreased expression:larynx epithelium (human)

RGD

NCBI chr10:81,283,171...81,283,280
Ensembl chr10:81,283,171...81,283,280

G

microRNA 34c

sexual_dimorphism

miRNA:increased expression:larynx epithelium (human)

RGD

NCBI chr 8:51,409,726...51,409,802
Ensembl chr 8:51,409,726...51,409,802

G

matrix metallopeptidase 9

RGD

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

N-acetyltransferase 1

susceptibility

DNA:polymorphism: :

RGD

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

prostaglandin-endoperoxide synthase 2

severity

protein:increased expression:larynx

RGD

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

secreted phosphoprotein 1

RGD

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

Laryngeal Papillomatosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

prostaglandin-endoperoxide synthase 2

RGD

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

serpin family A member 3N

protein:decreased expression:serum

RGD

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

transporter 1, ATP binding cassette subfamily B member

RGD

NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901

laryngeal squamous cell carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine deaminase

protein:decreased activity:larynx

RGD

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

catalase

protein:increased activity:larynx

RGD

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cell division cycle 73

disease_progression

protein:decreased expression:larynx (human)

RGD

NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656

G

cyclin-dependent kinase inhibitor 1A

RGD

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

chromodomain helicase DNA binding protein 4

exacerbates

mRNA:increased expression:larynx (human)

NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541

G

epidermal growth factor receptor

disease_progression

RGD

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

erb-b2 receptor tyrosine kinase 2

disease_progression

RGD

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 3

disease_progression

RGD

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

erb-b2 receptor tyrosine kinase 4

disease_progression

RGD

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

forkhead box L2

exacerbates

mRNA:increased expression:larynx (human)

RGD

NCBI chr 8:99,512,971...99,514,500
Ensembl chr 8:99,513,303...99,514,427

G

glutathione peroxidase 1

disease_progression
no_association

protein:increased expression:larynx (human)
DNA:missense mutation:CDS:p.P198L (human)
DNA:missense mutation:CDS:p.P198L (rs1050450) (human)

RGD

PMID:28641905 PMID:24074040 PMID:27188866

RGD:152995454, RGD:152995493, RGD:152995455

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

mitogen activated protein kinase kinase 4

severity

associated with Neoplasm Metastasis; protein:mRNA,increased expression:larynx epithelium (human)

RGD

NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993

G

microRNA 10a

severity

miRNA:decreased expression:blood serum (human)

NCBI chr10:81,283,171...81,283,280
Ensembl chr10:81,283,171...81,283,280

G

microRNA 136

RNA:decreased expression:larynx (human)

RGD

NCBI chr 6:128,549,096...128,549,177
Ensembl chr 6:128,549,096...128,549,177

G

microRNA 21

exacerbates

miRNA:increased expression:blood serum (human)

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 31

disease_progression

RNA:decreased expression:mucosa of larynx (human)

RGD

NCBI chr 5:103,599,038...103,599,143

G

mutL homolog 1

disease_progression

mRNA:decreased expression:larynx

RGD

NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617

G

matrix metallopeptidase 2

RGD

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

mutS homolog 2

disease_progression

mRNA:decreased expression:larynx

RGD

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

N-acetyltransferase 2

susceptibility

DNA:polymorphisms: :

RGD

PMID:19922706 PMID:16155914

RGD:5131602, RGD:5131856

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

phospholipase C, gamma 1

ameliorates

mRNA:increased expression:larynx (human)

RGD

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

RELA proto-oncogene, NF-kB subunit

severity

associated with Neoplasm Metastasis; protein:mRNA,increased expression:larynx epithelium (human)

RGD

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

xanthine dehydrogenase

protein:increased activity:larynx

RGD

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

G

X-ray repair cross complementing 1

ClinVar Annotator: match by term: Laryngeal squamous cell carcinoma

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

larynx cancer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-X-C motif chemokine ligand 12

exacerbates

protein:increased expression: mucosa of larynx (human)

RGD

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine receptor 4

exacerbates

protein:increased expression: mucosa of larynx (human)

RGD

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

ERCC excision repair 5, endonuclease

susceptibility

DNA:missense mutation:CDS:p.D1104H (human)

RGD

NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472

G

ERCC excision repair 6, chromatin remodeling factor

susceptibility

DNA:missense mutation:CDS:p.R1230P (human)

RGD

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

glutathione peroxidase 1

susceptibility

DNA:missense mutation:CDS: (rs1050450) (human)

RGD

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione S-transferase mu 1

DNA:deletion: :

RGD

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 3

RGD

NCBI chr 2:195,590,450...195,612,578
Ensembl chr 2:195,607,289...195,612,475

G

glutathione S-transferase, mu 5

NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553

G

mitogen activated protein kinase kinase 7

ameliorates

mRNA:increased expression:larynx (human)

RGD

NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222

G

nucleotide-binding oligomerization domain containing 2

onset

DNA:insertion:Cds: 3020_3021insC (human)

RGD

NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177

G

vascular endothelial growth factor A

treatment

RGD

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

lung adenocarcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 1B

CTD Direct Evidence: marker/mechanism

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily E member 1

severity

mRNA, protein:increased expression:lung (human)

RGD

NCBI chr19:28,205,566...28,230,489
Ensembl chr19:28,205,555...28,230,489

G

acyl-CoA synthetase long-chain family member 4

CTD Direct Evidence: marker/mechanism

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

ADAM metallopeptidase domain 19

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr10:30,491,362...30,583,115
Ensembl chr10:30,491,405...30,583,105

G

ADAM metallopeptidase domain 28

exacerbates
disease_progression
treatment

protein:increased expression:lung

RGD

PMID:29882245 PMID:26800504 PMID:30190423 PMID:20112342

RGD:153297792, RGD:11531771, RGD:153297795, RGD:153297794

NCBI chr15:43,774,463...43,840,726
Ensembl chr15:42,944,467...43,840,672

G

ADAMTS-like 3

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 1:136,288,793...136,596,986
Ensembl chr 1:136,288,793...136,596,986

G

adhesion G protein-coupled receptor G6

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 1:8,812,889...8,954,239
Ensembl chr 1:8,812,904...8,954,123

G

adenosylhomocysteinase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 1 member A1

disease_progression

RGD

NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674

G

AKT serine/threonine kinase 1

ClinVar Annotator: match by term: Adenocarcinoma of lung

PMID:17611497 PMID:18256540 PMID:18392055 PMID:18504432 PMID:18611285 More...

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

CTD Direct Evidence: marker/mechanism

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 18 family, member A1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890

G

aldolase, fructose-bisphosphate A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

ALK receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:18923525 PMID:20979469 PMID:20979473 PMID:21030459 PMID:21575866 More...

NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034

G

arachidonate 12-lipoxygenase, 12R type

CTD Direct Evidence: marker/mechanism

NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938

G

arachidonate 5-lipoxygenase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

ALX homeobox 1

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 7:38,157,626...38,177,220
Ensembl chr 7:38,147,117...38,177,220

G

ALX homeobox 4

disease_progression

RGD

NCBI chr 3:79,611,682...79,648,260
Ensembl chr 3:79,611,719...79,648,260

G

anaphase promoting complex subunit 2

severity

mRNA:decreased expression:lung (human)

RGD

NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178

G

acidic nuclear phosphoprotein 32 family member A

CTD Direct Evidence: marker/mechanism

NCBI chr 8:62,829,099...62,865,443
Ensembl chr 8:62,827,456...62,865,443

G

annexin A1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A5

CTD Direct Evidence: marker/mechanism

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

APC regulator of WNT signaling pathway

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:1316610 PMID:1338764 PMID:2281069 PMID:8187091 PMID:8381579 More...

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

apurinic/apyrimidinic endodeoxyribonuclease 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

apolipoprotein A1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein C3

protein:altered glycosylation::

RGD

NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583

G

aquaporin 4

CTD Direct Evidence: marker/mechanism

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

A-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:24569458 PMID:26619011

NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073

G

arginase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

Rho GTPase activating protein 35

CTD Direct Evidence: marker/mechanism

NCBI chr 1:77,202,436...77,319,298
Ensembl chr 1:77,202,436...77,319,298

G

Rho GTPase activating protein 44

mRNA:decreased expression:lung (human)

RGD

NCBI chr10:49,655,583...49,822,876
Ensembl chr10:49,655,584...49,824,297

G

ATP synthase peripheral stalk subunit d

CTD Direct Evidence: marker/mechanism

NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479

G

ATRX, chromatin remodeler

disease_progression

RGD

NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330

G

axin 2

susceptibility
disease_progression

DNA:SNP:cds:p.P50S(human)
DNA:SNPs::1712 +19 G>A,148 C>T(human)

RGD

PMID:16820935 PMID:30346805

RGD:151356657, RGD:151356655

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

alpha-2-glycoprotein 1, zinc-binding

mRNA,protein:increased expression:lung

RGD

NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091

G

beta-2 microglobulin

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

BRCA1 associated deubiquitinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535

G

basic helix-loop-helix family, member e41

mRNA:decreased expression:lung (human)

RGD

NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468

G

baculoviral IAP repeat-containing 3

exacerbates

mRNA:increased expression:B cell (human)

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

ameliorates
disease_progression

mRNA:increased expression:lung (human)

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

B-Raf proto-oncogene, serine/threonine kinase

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:12068308 PMID:12198537 PMID:12447372 PMID:12460918 PMID:12460919 More...

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

Bruton tyrosine kinase

exacerbates
susceptibility

mRNA:decreased expression:lung (human)

PMID:31803536 PMID:32351880

RGD:151347849, RGD:151347848

NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853

G

basic leucine zipper and W2 domains 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:52,828,069...52,888,599
Ensembl chr 6:52,827,661...52,888,628

G

cell adhesion molecule 1

DNA, mRNA:hypermethylation, decreased expression:promoter:liver

RGD

NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833

G

calreticulin

treatment

human cells and recombinant gene in a mouse model

RGD

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

capping actin protein, gelsolin like

CTD Direct Evidence: marker/mechanism

NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856

G

chromobox 5

disease_progression

mRNA,protein:increased expression:lung:

RGD

NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022

G

chromobox 7

mRNA,DNA:decreased expression, loss of heterozygosity:lung:

RGD

NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973

G

cyclin D1

disease_progression
treatment

RGD

PMID:26681199 PMID:19355812

RGD:11536846, RGD:13434927

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

disease_progression

RGD

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

chaperonin containing TCP1 subunit 5

CTD Direct Evidence: marker/mechanism

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

CD163 molecule

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878

G

CD44 molecule

disease_progression

mRNA:splice variants:lung
mRNA:increased expression:lung (human)

RGD

PMID:18091389 PMID:29537891

RGD:2289345, RGD:149735539

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

cell division cycle 73

exacerbates

mRNA:decreased expression:lung (human)

RGD

NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656

G

cadherin 1

DNA:increased methylation

RGD

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase 12

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr10:83,201,177...83,256,906
Ensembl chr10:83,201,211...83,280,888
Ensembl chr10:83,201,211...83,280,888

G

cyclin-dependent kinase 4

protein:increased expression:lung
ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:5377176 PMID:7652577 PMID:8528263 PMID:8968104 PMID:9228064 More...

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 6

protein:increased expression:lung

RGD

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 2A

ClinVar Annotator: match by term: Adenocarcinoma of lung

PMID:7780957 PMID:8521414 PMID:9324288 PMID:10491434 PMID:16234564 More...

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

chromodomain helicase DNA binding protein 4

susceptibility
ameliorates

mRNA:increased expression:lung (human)
DNA:missense mutation:CDS:p.D140E (rs7479004) (human)
human cells in a mouse model

PMID:28486105 PMID:29667179 PMID:32228507

RGD:153323299, RGD:151660359, RGD:153323307

NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541

G

cholinergic receptor nicotinic alpha 3 subunit

susceptibility

mRNA,protein:decreased expression:lung
ClinVar Annotator: match by term: Lung adenocarcinoma
DNA:SNPs:multiples:multiples (human)
protein:increased expression:lung
DNA:SNP: :rs8042374(human)
associated with smoking; DNA:SNP: :rs1051730(human)

PMID:27993330 PMID:19223495 PMID:25233467 PMID:24686516 PMID:24686516 More...

RGD:150524354, RGD:151347535, RGD:151347530, RGD:151347530, RGD:150527848

NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 5 subunit

susceptibility
disease_progression

DNA:SNP:cds: p.D398N (rs1696996)(human)
ClinVar Annotator: match by term: Lung adenocarcinoma
mRNA:increased expression:lung
DNA:SNP: :rs503464(human)
associated with smoking; DNA:SNPs: :rs2036527, rs684513, rs667282(human)
DNA:SNP:cds: p.D398N(human)

PMID:27993330 PMID:19223495 PMID:20124469 PMID:23314339 PMID:20554942 More...

RGD:150524354, RGD:150527851, RGD:150527849, RGD:150527848, RGD:150524359, RGD:150524356

NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146

G

cholinergic receptor nicotinic beta 4 subunit

mRNA:increased expression:lung
DNA:hypomethylation:promoter:

RGD

PMID:20124469 PMID:22945651

RGD:150527851, RGD:151361154

NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027

G

CLPTM1-like

susceptibility
no_association
ameliorates

CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs401681(human)
DNA:SNP::rs77518573(human)
DNA:SNP:: rs4975616(human)
DNA:SNP::rs401681(human)
DNA:SNP:: rs31490(human)
mRNA:increased expression:lung

CTD
RGD

PMID:22675468 PMID:24386361 PMID:31935503 PMID:19955392 PMID:24861918 More...

RGD:150537098, RGD:150530635, RGD:150530502, RGD:150530499, RGD:150530498, RGD:150530485, RGD:150530483, RGD:150530483

NCBI chr 1:29,667,545...29,683,530
Ensembl chr 1:29,667,545...29,683,530

G

cap methyltransferase 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:38,190,718...38,197,549
Ensembl chr19:38,190,642...38,197,804

G

collagen type X alpha 1 chain

disease_progression

mRNA:increased expression:lung

PMID:33324550 PMID:33324550

RGD:150429752, RGD:150429752

NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494

G

CREB binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

colony stimulating factor 1 receptor

protein:increased expression:lung (human)

RGD

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

cysteine and glycine rich protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653

G

catenin beta 1

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:9065402 PMID:9065403 PMID:9294210 PMID:9500465 PMID:9927029 More...

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine receptor 4

exacerbates

protein:increased expression:lung (human)
mRNA:increased expression:lung (human)

RGD

PMID:30103827 PMID:19716197

RGD:152023735, RGD:152177480

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome P450, family 1, subfamily b, polypeptide 1

protein:increased expression:lung (human)

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 24, subfamily a, polypeptide 1

ameliorates

DNA:hypomethylation:promoter (human)
mRNA:decreased expression:lung (human)
human cell line in a mouse model

RGD

PMID:24736069 PMID:25519225 PMID:27793774

RGD:151361181, RGD:151665499, RGD:151665173

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 2, subfamily a, polypeptide 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

discoidin domain receptor tyrosine kinase 2

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:26206333 PMID:27993330

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

delta like canonical Notch ligand 4

treatment

RGD

NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931

G

DNA methyltransferase 3 alpha

ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:21067377 PMID:21518476 PMID:22160010 PMID:22722925 PMID:22744846 More...

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

DNA methyltransferase 3 beta

susceptibility

DNA:SNPs,haplotype:promoter:-283T >C,-579G>T(human)

RGD

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

docking protein 1

disease_progression

RGD

NCBI chr 4:115,537,453...115,540,464
Ensembl chr 4:115,537,462...115,540,465

G

docking protein 2

disease_progression
exacerbates

mRNA:decreased expression:lung (human)

PMID:20139980 PMID:30475228 PMID:20139980 PMID:24255704

RGD:152177521, RGD:152177492, RGD:152177521, RGD:152177493

NCBI chr15:45,826,984...45,841,409
Ensembl chr15:45,827,398...45,841,402

G

docking protein 3

disease_progression

RGD

NCBI chr17:9,109,633...9,115,188
Ensembl chr17:9,109,597...9,115,188

G

DOT1 like histone lysine methyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chr 7:8,918,764...8,959,474
Ensembl chr 7:8,917,786...8,956,475

G

E2F transcription factor 1

mRNA:increased expression:lung

RGD

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 3

RGD

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

eukaryotic translation elongation factor 2

exacerbates

protein:increased expression:lung (human)

RGD

NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183

G

eukaryotic elongation factor-2 kinase

ameliorates

Human cells in mouse model

RGD

NCBI chr 1:175,393,119...175,456,756
Ensembl chr 1:175,393,154...175,455,164

G

epidermal growth factor

DNA:polymorphism: :p.A61G (human)

RGD

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

disease_progression

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Adenocarcinoma of lung, somatic | ClinVar Annotator: match by term: Lung adenocarcinoma

CTD
ClinVar
RGD

PMID:2302402 PMID:11423618 PMID:15118073 PMID:15118125 PMID:15272417 More...

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

euchromatic histone lysine methyltransferase 2

disease_progression

RGD

NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547

G

eukaryotic translation initiation factor 2B subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr12:32,025,593...32,033,848
Ensembl chr12:32,025,557...32,046,601

G

eukaryotic translation initiation factor 2B subunit delta

CTD Direct Evidence: marker/mechanism

NCBI chr 6:25,183,177...25,188,832
Ensembl chr 6:25,183,186...25,188,829

G

eukaryotic translation initiation factor 2B subunit epsilon

CTD Direct Evidence: marker/mechanism

NCBI chr11:80,394,433...80,404,468
Ensembl chr11:80,394,433...80,404,419

G

eukaryotic translation initiation factor 3 subunit E

CTD Direct Evidence: marker/mechanism

NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096

G

EMAP like 4

CTD Direct Evidence: marker/mechanism

PMID:22980554 PMID:22999080

NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879

G

empty spiracles homeobox 2

exacerbates

mRNA,protein:decreased expression:lung (human)

RGD

NCBI chr 1:258,626,584...258,633,594
Ensembl chr 1:258,626,584...258,633,594

G

enolase 1

CTD Direct Evidence: marker/mechanism

PMID:19381893 PMID:27602772

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

E1A binding protein p300

CTD Direct Evidence: marker/mechanism

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

EPH receptor A5

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr14:23,653,393...24,020,129
Ensembl chr14:23,653,393...24,017,317

G

erb-b2 receptor tyrosine kinase 2

disease_progression

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:15457249 PMID:15753357 PMID:16638863 PMID:18334834 PMID:22325357 More...

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 3

disease_progression

RGD

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

erb-b2 receptor tyrosine kinase 4

disease_progression

RGD

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

ERCC excision repair 1, endonuclease non-catalytic subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

ERCC excision repair 6, chromatin remodeling factor

mRNA, protein:increased expression:lung (human)

RGD

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

ERCC excision repair 6 like, spindle assembly checkpoint helicase

exacerbates

mRNA:increased expression:lung (human)

RGD

NCBI chr X:67,245,414...67,261,222
Ensembl chr X:67,245,414...67,280,756

G

ERGIC and golgi 3

ameliorates
disease_progression

mRNA,protein:increased expression:lung (human)

RGD

PMID:27588471 PMID:23374247

RGD:153323314, RGD:151708716

NCBI chr 3:144,525,059...144,534,813
Ensembl chr 3:144,525,092...144,534,813

G

endoplasmic reticulum protein 29

CTD Direct Evidence: marker/mechanism

NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376

G

establishment of sister chromatid cohesion N-acetyltransferase 2

ameliorates

RGD

NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

disease_progression

RGD

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

Fas cell surface death receptor

mRNA:decreased expression:lung (human)

RGD

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

CTD Direct Evidence: marker/mechanism

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibrillarin

CTD Direct Evidence: marker/mechanism

NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932

G

F-box and WD repeat domain containing 7

ClinVar Annotator: match by term: Adenocarcinoma of lung

NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941

G

FES proto-oncogene, tyrosine kinase

treatment

human cells in a mouse model

RGD

NCBI chr 1:134,337,698...134,346,934
Ensembl chr 1:134,337,698...134,346,934

G

fibroblast growth factor 10

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866

G

fibroblast growth factor 18

mRNA:decreased expression:lung (human)

NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818

G

fibroblast growth factor 9

disease_progression

protein:increased expression:lung (human)
mRNA:decreased expression:lung (human)

PMID:19296538 PMID:19358281 PMID:20464547

RGD:150429981 RGD:152177688, RGD:152975620

NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309

G

fibroblast growth factor receptor 2

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:17525745 PMID:18552176 PMID:22238366 PMID:23002168 PMID:23908597 More...

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

fibroblast growth factor receptor 3

ClinVar Annotator: match by term: Adenocarcinoma of lung

PMID:1908846 PMID:7773297 PMID:8640234 PMID:8858131 PMID:9438390 More...

NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341

G

fibroblast growth factor receptor 4

disease_progression
exacerbates

DNA:SNP:exon 9: p.G288R (human)
DNA:SNP:exon 9: p.G388R (rs351855)(human)
human cells in mouse model

RGD

PMID:16061909 PMID:19296538 PMID:29402970

RGD:150429976, RGD:150429981, RGD:150429984

NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242

G

FKBP prolyl isomerase 11

CTD Direct Evidence: marker/mechanism

NCBI chr 7:129,871,870...129,877,760
Ensembl chr 7:129,871,870...129,875,303

G

Fms related receptor tyrosine kinase 1

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

forkhead box A1

mRNA:increased expression:lung
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:34254728 PMID:12234996 PMID:29072684

RGD:151665758, RGD:151665822

NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188

G

forkhead box O3

CTD Direct Evidence: marker/mechanism

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

forkhead box P1

mRNA:decreased expression:lung (rat)

RGD

NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258

G

forkhead box P2

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683

G

forkhead box P4

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 9:13,058,506...13,115,406
Ensembl chr 9:13,058,476...13,114,879

G

formyl peptide receptor 2

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 1:58,776,592...58,785,227
Ensembl chr 1:58,776,752...58,786,019

G

frizzled-related protein

severity

mRNA:decreased expression:lung (human)

NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208

G

far upstream element binding protein 1

mRNA:decreased expression:lung (human)

RGD

NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602

G

glyceraldehyde-3-phosphate dehydrogenase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

GAR1 ribonucleoprotein

CTD Direct Evidence: marker/mechanism

NCBI chr 2:218,375,231...218,382,509
Ensembl chr 2:218,375,353...218,382,524

G

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

CTD Direct Evidence: marker/mechanism

NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125

G

gap junction protein, beta 2

DNA, mRNA:hypermethylation, decreased expression:lung

RGD

NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177

G

GNAS complex locus

ClinVar Annotator: match by term: Adenocarcinoma of lung

PMID:1517386 PMID:1594625 PMID:1944469 PMID:2549426 PMID:3720010 More...

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

G protein subunit gamma 11

CTD Direct Evidence: marker/mechanism

NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442

G

glucosamine-phosphate N-acetyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:18,596,180...18,608,854
Ensembl chr15:18,596,442...18,608,739

G

golgi membrane protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:4,995,925...5,044,329
Ensembl chr17:4,996,104...5,034,057

G

glucose-6-phosphate isomerase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086

G

glutathione peroxidase 3

mRNA:decreased expression:lung (human)

RGD

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glutamate-rich WD repeat containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:96,301,260...96,306,962
Ensembl chr 1:96,301,261...96,307,201

G

H1.10 linker histone

CTD Direct Evidence: marker/mechanism

NCBI chr 4:120,440,515...120,441,578
Ensembl chr 4:120,440,870...120,441,448

G

helicase, lymphoid specific

CTD Direct Evidence: marker/mechanism

NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844

G

hexokinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131

G

hexokinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

high mobility group box 2

CTD Direct Evidence: marker/mechanism

PMID:24366584 PMID:27602772

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
Ensembl chr 1:32,710,658...32,713,140

G

heterogeneous nuclear ribonucleoprotein A1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609

G

homeo box B7

severity

protein:increased expression:lung epithelium (human)

RGD

NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034

G

HRas proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:1904555 PMID:3510078 PMID:11150980 PMID:12835555 PMID:16155195 More...

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

hydroxysteroid (17-beta) dehydrogenase 10

CTD Direct Evidence: marker/mechanism

NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488

G

heat shock protein 90 beta family member 1

mRNA:increased expression:lung (human)

RGD

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family B (small) member 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

5-hydroxytryptamine receptor 4

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr18:55,765,981...55,949,921
Ensembl chr18:55,766,725...55,949,321

G

HtrA serine peptidase 1

disease_progression

human cells in mouse model

RGD

NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379

G

isocitrate dehydrogenase (NADP(+)) 1

disease_progression

mRNA:increased expression:lung (human)
ClinVar Annotator: match by term: Adenocarcinoma of lung
protein:increased expression:blood plasma (human)

PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20946881 More...

RGD:149735539, RGD:149735540

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

G

isocitrate dehydrogenase (NADP(+)) 2

severity

protein:increased expression:lung (human)
protein:increased expression:blood serum (human)

RGD

PMID:30128035 PMID:29465809

RGD:149735564, RGD:149735567

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

insulin-like growth factor 2 receptor

mRNA:deletions: :c.3698_4902del, c.3366_4902del, c.3817_4697del (rat)

RGD

NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501

G

IKAROS family zinc finger 1

exacerbates
ameliorates

protein:increased expression:lung (human)
mRNA:increased expression:lung (human)

PMID:33738286 PMID:32787735

RGD:151347632, RGD:150540324

NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416

G

interleukin 1 receptor type 2

disease_progression
severity

mRNA:altered expression:lung (human)
mRNA:increased expression:lung (human)

RGD

PMID:31921619 PMID:29942094

RGD:152998982, RGD:152998998

NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725

G

inosine monophosphate dehydrogenase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359

G

importin 4

CTD Direct Evidence: marker/mechanism

NCBI chr15:29,117,365...29,127,382
Ensembl chr15:29,117,365...29,127,285

G

importin 5

CTD Direct Evidence: marker/mechanism

NCBI chr15:97,990,755...98,041,074
Ensembl chr15:98,005,299...98,041,126

G

IQ motif and Sec7 domain ArfGEF 1

disease_progression

RGD

NCBI chr 4:123,168,719...123,488,300
Ensembl chr 4:123,168,719...123,488,172

G

interleukin-1 receptor-associated kinase 3

mRNA:increased expression:lung (human)

NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121

G

iron responsive element binding protein 2

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611

G

Janus kinase 2

treatment

human cells in mouse model

RGD

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

JunB proto-oncogene, AP-1 transcription factor subunit

CTD Direct Evidence: marker/mechanism

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

potassium inwardly-rectifying channel, subfamily J, member 4

CTD Direct Evidence: marker/mechanism

NCBI chr 7:111,047,097...111,074,151
Ensembl chr 7:111,047,094...111,074,151

G

KLF transcription factor 5

CTD Direct Evidence: marker/mechanism

NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445

G

lysine methyltransferase 2C

disease_progression
onset

RGD

PMID:32867667 PMID:30821106

RGD:151356760, RGD:151356761

NCBI chr 4:9,620,638...9,834,787
Ensembl chr 4:9,609,627...9,833,539

G

karyopherin subunit alpha 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150

G

KRAS proto-oncogene, GTPase

DNA:point mutation:CDS:p.G12C (human)
ClinVar Annotator: match by term: Adenocarcinoma of lung
CTD Direct Evidence: marker/mechanism

ClinVar
CTD
RGD

PMID:2278970 PMID:3122217 PMID:6320174 PMID:8143615 PMID:8425762 More...

NCBI chr 4:178,185,418...178,218,484

G

lactate dehydrogenase A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

leukocyte cell-derived chemotaxin 2

ameliorates

human cells in mouse model

RGD

NCBI chr17:8,044,759...8,050,983
Ensembl chr17:8,044,759...8,050,983

G

lamin A/C

CTD Direct Evidence: marker/mechanism

NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423

G

lamin B1

CTD Direct Evidence: marker/mechanism

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

LDL receptor related protein 1B

disease_progression

DNA:mutations:multiple: (human)

RGD

NCBI chr 3:24,594,302...26,715,037
Ensembl chr 3:24,594,991...26,715,505

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:1904555 PMID:3510078 PMID:11150980 PMID:12835555 PMID:16155195 More...

NCBI chr 1:196,299,843...196,315,170
Ensembl chr 1:196,299,846...196,315,172

G

mitogen activated protein kinase kinase 1

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma
mRNA:increased expression:lung (human)

CTD
ClinVar
RGD

PMID:18632602 PMID:21383288 PMID:22135231 PMID:22197931 PMID:22588879 More...

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 4

severity

RGD

PMID:21896780 PMID:12231543

RGD:150429783, RGD:150429821

NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993

G

mitogen activated protein kinase kinase 7

exacerbates

human gene in a mouse model

RGD

NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222

G

mitogen-activated protein kinase kinase kinase 8

exacerbates

RGD

NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216

G

mitogen-activated protein kinase kinase kinase kinase 4

ameliorates
exacerbates

human cell line in a mouse model
mRNA, protein:increased expression:lung (human)

PMID:22824148 PMID:28306189 PMID:33510968

RGD:151347677, RGD:151347678, RGD:151347681

NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698

G

mitogen activated protein kinase 14

exacerbates

mRNA:increased expression:lung (human)

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

MCL1 apoptosis regulator, BCL2 family member

severity
treatment

mRNA:increased expression:lung (human)
human cells in mouse model

RGD

PMID:31200834 PMID:31200834

RGD:151356911, RGD:151356911

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

mesenchyme homeobox 1

CTD Direct Evidence: therapeutic

NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660

G

MIER family member 3

ameliorates

RGD

NCBI chr 2:43,287,546...43,316,422
Ensembl chr 2:43,287,916...43,316,136

G

microRNA 127

treatment

Human cells in mouse model

RGD

NCBI chr 6:128,546,215...128,546,311
Ensembl chr 6:128,546,215...128,546,311

G

microRNA 154

associated with nicotine dependence; RNA:decreased expression:blood serum (human)

RGD

NCBI chr 6:128,752,947...128,753,030
Ensembl chr 6:128,752,947...128,753,030

G

microRNA 20a

RGD

NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168

G

microRNA 21

disease_progression

RNA:increased expression:lung (human)
miRNA:increased expression:sputum (human)

RGD

PMID:29892003 PMID:27777637

RGD:152998892, RGD:152998954

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 31

severity
disease_progression

RNA:increased expression:lung (human)

RGD

PMID:26657862 PMID:29367106 PMID:23946296 PMID:27215092

RGD:11343268, RGD:152998945, RGD:152998944, RGD:11250998

NCBI chr 5:103,599,038...103,599,143

G

marker of proliferation Ki-67

disease_progression

protein:altered expression:lung (human)

RGD

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

mutL homolog 1

ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:15340264 PMID:17510385 PMID:18307539 PMID:19419416 PMID:22136435 More...

NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617

G

MRE11 homolog, double strand break repair nuclease

CTD Direct Evidence: marker/mechanism

NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279

G

mitochondrial ribosomal protein L12

CTD Direct Evidence: marker/mechanism

NCBI chr10:105,758,410...105,762,913
Ensembl chr10:105,758,410...105,762,913

G

mitochondrial ribosomal protein S5

CTD Direct Evidence: marker/mechanism

NCBI chr 3:114,821,046...114,837,291
Ensembl chr 3:114,821,046...114,837,291

G

membrane spanning 4-domains A1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:207,906,370...207,927,028
Ensembl chr 1:207,906,374...207,918,512

G

mutS homolog 2

no_association

DNA:polymorphisms:introns:IVS10+12A>G, IVS12-6T>C (human)
DNA:polymorphisms:promoter, intron:-118T>C, IVS1+9G>C (human)

RGD

PMID:16614121 PMID:16614121

RGD:11065547, RGD:11065547

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

mutS homolog 3

CTD Direct Evidence: marker/mechanism

NCBI chr 2:23,444,326...23,585,777

G

mutS homolog 6

CTD Direct Evidence: marker/mechanism

NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956

G

mucin 1, cell surface associated

mRNA:increased expression:lung

RGD

NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733

G

mucin 4, cell surface associated

disease_progression

protein:increased expression:trachea

RGD

NCBI chr11:68,008,245...68,053,242

G

mucin 5AC, oligomeric mucus/gel-forming

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

MYC proto-oncogene, bHLH transcription factor

human cell line in mouse model
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma

CTD
ClinVar
RGD

PMID:25157968 PMID:26619011 PMID:26656844 PMID:27602772 PMID:20033209

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYD88, innate immune signal transduction adaptor

treatment
ameliorates

mouse cell line in a mouse model

RGD

PMID:32140881 PMID:30712876

RGD:150520172, RGD:150540309

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

N(alpha)-acetyltransferase 10, NatA catalytic subunit

CTD Direct Evidence: marker/mechanism

NCBI chr X:151,656,056...151,661,304
Ensembl chr X:151,656,056...151,661,252

G

NLR family, apoptosis inhibitory protein 6

ameliorates

mRNA:increased expression:lung (human)

NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542

G

non-SMC condensin I complex, subunit G

CTD Direct Evidence: marker/mechanism

NCBI chr14:65,403,930...65,432,902
Ensembl chr14:65,404,163...65,432,902

G

nucleolin

CTD Direct Evidence: marker/mechanism

NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136

G

NFE2 like bZIP transcription factor 2

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:26619011 PMID:29018201

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NK2 homeobox 1

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791

G

NLR family, pyrin domain containing 3

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

NOP56 ribonucleoprotein

CTD Direct Evidence: marker/mechanism

NCBI chr 3:117,476,963...117,481,847
Ensembl chr 3:117,477,053...117,481,841

G

NOP58 ribonucleoprotein

CTD Direct Evidence: marker/mechanism

NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810

G

notch receptor 1

treatment

RGD

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

nucleophosmin 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
Ensembl chr X:17,739,941...17,751,645

G

nucleophosmin/nucleoplasmin, 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:244,595,638...244,597,623
Ensembl chr 1:244,595,644...244,597,591

G

NRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Adenocarcinoma of lung

PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 More...

NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626

G

nudix hydrolase 21

CTD Direct Evidence: marker/mechanism

NCBI chr19:10,974,800...10,993,841
Ensembl chr19:10,974,241...10,991,682

G

NUF2 component of NDC80 kinetochore complex

disease_progression

RGD

NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766

G

8-oxoguanine DNA glycosylase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

poly(A) binding protein, cytoplasmic 4

CTD Direct Evidence: marker/mechanism

NCBI chr 5:135,563,142...135,578,985
Ensembl chr 5:135,563,562...135,578,979

G

parkin coregulated

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 1:49,882,671...50,305,564
Ensembl chr 1:49,882,630...50,305,430

G

pterin-4 alpha-carbinolamine dehydratase 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:29,037,545...29,044,322
Ensembl chr20:28,953,864...29,044,292
Ensembl chr20:28,953,864...29,044,292

G

phosphatidylinositol glycan anchor biosynthesis, class N

CTD Direct Evidence: marker/mechanism

NCBI chr13:21,659,092...21,812,932
Ensembl chr13:21,662,455...21,806,790

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 More...

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phosphoinositide-3-kinase regulatory subunit 1

mRNA:decreased expression:lung

RGD

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

paired-like homeodomain 2

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 2:217,717,738...217,737,293
Ensembl chr 2:217,717,693...217,737,293

G

phospholipase C, gamma 1

exacerbates

protein:decreased expression:lung (human)

RGD

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

disease_progression

RGD

NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255

G

DNA polymerase delta 1, catalytic subunit

exacerbates

protein:increased expression:lung (human)

NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465

G

RNA polymerase I and III subunit D

CTD Direct Evidence: marker/mechanism

NCBI chr12:7,970,592...8,004,157
Ensembl chr12:7,970,595...8,005,624

G

peter pan homolog

CTD Direct Evidence: marker/mechanism

NCBI chr 8:19,423,908...19,427,941
Ensembl chr 8:19,423,961...19,427,938

G

protein phosphatase 2 scaffold subunit A alpha

ClinVar Annotator: match by term: Adenocarcinoma of lung

PMID:25741868 PMID:26168268 PMID:26619011 PMID:28492532 PMID:31687265 More...

NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129

G

protein phosphatase 3 catalytic subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974

G

PRAME like, X-linked 1

mRNA:decreased expression:lung (human)

RGD

NCBI chr X:98,567,994...98,574,654
Ensembl chr X:98,569,415...98,572,096

G

PR/SET domain 1

exacerbates

RGD

NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488

G

parkin RBR E3 ubiquitin protein ligase

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

phosphoserine aminotransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

patched 1

ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:27993330 PMID:28492532 PMID:33359005

NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333

G

phosphatase and tensin homolog

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

protein tyrosine phosphatase, non-receptor type 11

ClinVar Annotator: match by term: Adenocarcinoma of lung

PMID:26619011 PMID:26822237

NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925

G

protein tyrosine phosphatase, non-receptor type 13

exacerbates
susceptibility

mRNA,protein:decreased expression:lung
DNA:missense mutations:cds:p.I1522M, p.Y2081D (human)

RGD

PMID:22245727 PMID:33536603 PMID:19672627

RGD:152176663, RGD:152975626, RGD:152176665

NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563

G

protein tyrosine phosphatase, receptor type, B

disease_progression

mRNA:altered expression:lung (human)
mRNA:decreased expression:lung (human)

RGD

PMID:29254206 PMID:7981622

RGD:151665107, RGD:151665112

NCBI chr 7:51,953,375...52,034,751
Ensembl chr 7:51,930,015...52,034,748

G

protein tyrosine phosphatase, receptor type, J

susceptibility

DNA:missense mutations:cds:p.R326Q, p.Q276P (human)

RGD

NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260

G

Rac family small GTPase 1

exacerbates
ameliorates

mRNA:increased expression:lung (human)

PMID:31779616 PMID:32366477

RGD:152998910, RGD:153345550

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

Raf-1 proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:1760348 PMID:8601312 PMID:10064593 PMID:12077328 PMID:17603482 More...

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RAN guanine nucleotide release factor

CTD Direct Evidence: marker/mechanism

NCBI chr10:53,677,467...53,678,880
Ensembl chr10:53,677,467...53,678,840

G

retinoic acid receptor, beta

DNA:hypomethylation:lung

RGD

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

RAS p21 protein activator 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854

G

RB transcriptional corepressor 1

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RNA binding motif protein 10

mRNA, protein:decreased expression:lung
DNA:missense mutations, protein-truncating variants: :multiple

RGD

PMID:29085465 PMID:22980975 PMID:30955253

RGD:151356983, RGD:11097386, RGD:151356984

NCBI chr X:1,540,399...1,572,571
Ensembl chr X:1,540,398...1,572,575

G

RNA terminal phosphate cyclase-like 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:226,824,561...226,869,046
Ensembl chr 1:226,824,534...226,902,315

G

replication factor C subunit 4

CTD Direct Evidence: marker/mechanism

NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122

G

ras homolog family member A

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

Ras and Rab interactor 3

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 6:121,431,776...121,540,956
Ensembl chr 6:121,431,339...121,540,957

G

ribonuclease H2, subunit A

CTD Direct Evidence: marker/mechanism

NCBI chr19:23,186,325...23,196,045
Ensembl chr19:23,186,383...23,196,041

G

ring finger protein 43

severity

human cells in a mouse model

RGD

NCBI chr10:72,461,508...72,537,301
Ensembl chr10:72,464,348...72,536,977

G

ROS proto-oncogene 1 , receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:22215748 PMID:23724914 PMID:27993330

NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865

G

ribosomal protein L10A

CTD Direct Evidence: marker/mechanism

NCBI chr20:6,388,800...6,391,358
Ensembl chr20:6,385,823...6,391,357
Ensembl chr 9:6,385,823...6,391,357

G

ribosomal protein L13A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:95,609,374...95,612,557
Ensembl chr 1:95,609,370...95,620,463

G

ribosomal protein L27A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:163,539,732...163,542,771

G

ribosomal protein L36A

CTD Direct Evidence: marker/mechanism

NCBI chr X:97,766,179...97,768,892
Ensembl chr X:97,766,179...97,768,892
Ensembl chr20:97,766,179...97,768,892

G

ribosomal protein SA

CTD Direct Evidence: marker/mechanism

NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247

G

ribonucleotide reductase catalytic subunit M1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261

G

ribonucleotide reductase regulatory subunit M2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

ribosome biogenesis regulator 1 homolog

CTD Direct Evidence: marker/mechanism

NCBI chr 5:9,733,486...9,735,119
Ensembl chr 5:9,733,091...9,735,140

G

RUNX family transcription factor 1

RGD

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

SATB homeobox 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:4,677,817...4,773,061
Ensembl chr 9:4,680,920...4,753,251

G

syndecan 1

mRNA:increased expression:lung (human)

RGD

NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264

G

serpin family A member 3N

protein:increased expression:cytoplasm

RGD

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

SET domain containing 2, histone lysine methyltransferase

ameliorates
exacerbates
severity

human cells and genes in mouse model
DNA:mutations:multiple (human)

RGD

PMID:33223508 PMID:27687306 PMID:33707235 PMID:28202515

RGD:150429633, RGD:150429649, RGD:150429648, RGD:126848875

NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489

G

stratifin

CTD Direct Evidence: marker/mechanism

NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314

G

surfactant protein C

CTD Direct Evidence: marker/mechanism

NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777

G

sideroflexin 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529

G

serine hydroxymethyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820

G

solute carrier family 15 member 2

CTD Direct Evidence: marker/mechanism

NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225

G

solute carrier family 19 member 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972

G

solute carrier family 1 member 5

disease_progression

RGD

NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 22, member 18

disease_progression

mRNA:increased expression:lung (human)
ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:27993330 PMID:32726996

NCBI chr 1:198,670,626...198,694,977
Ensembl chr 1:198,671,731...198,694,975

G

solute carrier family 3 member 2

disease_progression

RGD

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 4 member 4

CTD Direct Evidence: marker/mechanism

NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883

G

solute carrier family 4 member 7

CTD Direct Evidence: marker/mechanism

NCBI chr15:10,585,307...10,664,780
Ensembl chr15:10,588,979...10,664,781

G

solute carrier family 7 member 5

disease_progression

RGD

PMID:26279756 PMID:19171406

RGD:151361150, RGD:151361151

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

SMAD family member 4

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:6604412 PMID:8898652 PMID:9214508 PMID:9285566 PMID:9582123 More...

NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438

G

SWI/SNF related BAF chromatin remodeling complex subunit C1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:110,111,097...110,214,734
Ensembl chr 8:110,111,122...110,214,720

G

small nucleolar RNA, C/D box 22

CTD Direct Evidence: marker/mechanism

NCBI chr11:9,097,799...9,097,923
Ensembl chr11:9,097,799...9,097,923

G

small nuclear ribonucleoprotein polypeptides B and B1

severity

mRNA:increased expression:lung (human)

RGD

NCBI chr 3:117,369,816...117,379,344
Ensembl chr 3:117,370,100...117,379,339

G

small nuclear ribonucleoprotein polypeptide E

severity

mRNA:increased expression:lung (human)

RGD

NCBI chr13:45,050,986...45,057,231
Ensembl chr13:45,050,986...45,057,310
Ensembl chr 8:45,050,986...45,057,310

G

small nuclear ribonucleoprotein polypeptide G

CTD Direct Evidence: marker/mechanism

NCBI chr 4:118,812,278...118,819,827
Ensembl chr 4:118,812,252...118,819,826
Ensembl chr X:118,812,252...118,819,826

G

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

SOS Ras/Rac guanine nucleotide exchange factor 1

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:25741868 PMID:26619011 PMID:27158780

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

G

SRY-box transcription factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

SRY-box transcription factor 30

disease_progression

RGD

NCBI chr10:30,417,499...30,446,441
Ensembl chr10:30,418,473...30,446,453

G

SRY-box transcription factor 4

protein:increased expression:lung

RGD

NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665

G

speckle type BTB/POZ protein

ameliorates

human gene and cell line in mouse model
mRNA, protein:increased expression:lung (human)

RGD

PMID:30607139 PMID:31105033

RGD:153298920, RGD:153298927

NCBI chr10:80,358,121...80,438,983
Ensembl chr10:80,358,124...80,483,955

G

SRC proto-oncogene, non-receptor tyrosine kinase

severity

RGD

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

spermidine synthase

CTD Direct Evidence: marker/mechanism

NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405

G

serine racemase

CTD Direct Evidence: marker/mechanism

NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011

G

serine and arginine rich splicing factor 1

severity

RGD

NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336

G

serine and arginine rich splicing factor 2

severity

RGD

NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338

G

serine/threonine kinase 11

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:10408777 PMID:12865922 PMID:15561763 PMID:15863673 PMID:16287113 More...

NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315

G

serine threonine kinase 39

CTD Direct Evidence: marker/mechanism

NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060

G

spermatid perinuclear RNA binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949

G

succinate-CoA ligase GDP-forming subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170

G

sulfotransferase family 1A member 1

DNA:SNP:exon:p.R213H, 638G>A (human)

RGD

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

telomerase reverse transcriptase

susceptibility

DNA:SNP: :rs2736098(human)
DNA:SNP::rs33963617(human)
DNA:SNP:: rs2736100(human)
DNA:SNPs:: rs2853669,rs2736108(human)

RGD

PMID:23738012 PMID:31935503 PMID:24761905 PMID:19955392 PMID:23908149

RGD:150530485, RGD:150530635, RGD:150530628, RGD:150530502, RGD:150530498

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

transferrin

CTD Direct Evidence: marker/mechanism

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transforming growth factor, beta 2

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

translocase of inner mitochondrial membrane 10

CTD Direct Evidence: marker/mechanism

NCBI chr 3:69,908,397...69,911,943
Ensembl chr 3:69,908,456...69,911,940

G

translocase of inner mitochondrial membrane 8A1

CTD Direct Evidence: marker/mechanism

NCBI chr X:97,717,932...97,722,170
Ensembl chr X:97,717,920...97,721,960

G

TIMP metallopeptidase inhibitor 3

mRNA:decreased expression:lung (human)

RGD

NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839

G

thymidine kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920

G

toll-like receptor 4

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

TNF superfamily member 10

CTD Direct Evidence: therapeutic

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

translocase of outer mitochondrial membrane 40

CTD Direct Evidence: marker/mechanism

NCBI chr 1:79,358,781...79,370,882
Ensembl chr 1:79,358,786...79,370,915

G

DNA topoisomerase II alpha

CTD Direct Evidence: marker/mechanism

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Adenocarcinoma of lung, somatic | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:124622 PMID:253702 PMID:960674 PMID:1349175 PMID:1565143 More...

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p63

CTD Direct Evidence: marker/mechanism

NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398

G

triosephosphate isomerase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

Tnf receptor associated factor 4

mRNA:increased expression:lung (human)

RGD

NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284

G

transcription termination factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:12,384,626...12,409,257
Ensembl chr 3:12,384,655...12,409,257

G

transthyretin

mRNA,protein:increased expression:lung (human)

NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008

G

thymidylate synthetase

CTD Direct Evidence: marker/mechanism

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

G

U2 small nuclear RNA auxiliary factor 1

ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:22158538 PMID:23029227 PMID:23861105 PMID:24498085 PMID:26619011

NCBI chr20:9,742,904...9,753,840
Ensembl chr20:9,742,905...9,753,832

G

ubiquitin protein ligase E3 component n-recognin 5

ameliorates

human cell line in a mouse model

RGD

NCBI chr 7:69,115,216...69,224,843
Ensembl chr 7:69,116,761...69,224,903

G

uridine-cytidine kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr13:79,380,807...79,438,121
Ensembl chr13:79,383,846...79,438,352

G

vav guanine nucleotide exchange factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:2,161,985...2,209,951
Ensembl chr 9:2,157,900...2,208,937

G

WD repeat containing, antisense to TP53

severity

RGD

NCBI chr10:54,282,092...54,299,908
Ensembl chr10:54,282,105...54,298,929

G

XPC complex subunit, DNA damage recognition and repair factor

CTD Direct Evidence: marker/mechanism

PMID:21327329 PMID:27777383

NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010

G

exportin 1

exacerbates

circRNA:increased expression:lung (human)

RGD

NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498

G

X-ray repair cross complementing 1

susceptibility
severity

DNA:missense mutation:cds: p.R399Q (human)
DNA:missense mutation:exon 10: p.R399Q (rs25487) (human)

RGD

PMID:11104903 PMID:20003463

RGD:151347406, RGD:151347422

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

G

X-ray repair cross complementing 5

CTD Direct Evidence: marker/mechanism

NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018

G

X-ray repair cross complementing 6

CTD Direct Evidence: marker/mechanism

NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762

G

zinc finger homeobox 3

ameliorates

DNA:mutations:multiple (human)

RGD

NCBI chr19:36,257,196...36,886,104
Ensembl chr19:36,630,254...36,881,771

lung adenoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

anaphase promoting complex subunit 2

mRNA:decreased expression:lung (human)

RGD

NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178

G

microRNA 21

RNA:increased expression:lung:

RGD

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

lung cancer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

treatment

RGD

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

angiotensin I converting enzyme

susceptibility

DNA:polymorphism (human)

RGD

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

acyl-CoA synthetase long-chain family member 3

RGD

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

actin alpha 2, smooth muscle

ClinVar Annotator: match by term: LUNG CANCER, SUSCEPTIBILITY TO

PMID:15937082 PMID:25741868

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

ALK receptor tyrosine kinase

ClinVar Annotator: match by term: Lung cancer

PMID:20979473 PMID:21575866 PMID:22277784 PMID:24327273 PMID:24670165 More...

NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034

G

ALX homeobox 4

DNA:hypermethylation:CpG_island:

RGD

NCBI chr 3:79,611,682...79,648,260
Ensembl chr 3:79,611,719...79,648,260

G

ATM serine/threonine kinase

ClinVar Annotator: match by term: Lung cancer

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATR serine/threonine kinase

treatment

RGD

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

axin 1

disease_progression
treatment

DNA:hypermethylation
protein:decreased expression:lung (human)
human cells in mouse model

RGD

PMID:23192643 PMID:21496867 PMID:32051824 PMID:23915259

RGD:150527862, RGD:150530293, RGD:150530284, RGD:150530274

NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615

G

axin 2

susceptibility

DNA:SNPs:exons,introns:
DNA:SNP:exon:148T>C(rs2240308)(human)

RGD

PMID:28378643 PMID:25091576

RGD:151356504, RGD:151356659

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

BRCA1 associated RING domain 1

ClinVar Annotator: match by term: Lung cancer

PMID:19197335 PMID:20077502 PMID:25741868 PMID:26467025 PMID:26738429 More...

NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265

G

bone morphogenetic protein 2

ClinVar Annotator: match by term: Lung cancer

PMID:21515830 PMID:24465802 PMID:26253951

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Lung cancer, somatic

PMID:16439621 PMID:16474404 PMID:17366577 PMID:17551924 PMID:17703371 More...

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

BRCA1, DNA repair associated

ClinVar Annotator: match by term: Lung cancer, somatic

PMID:8554067 PMID:9760198 PMID:10486320 PMID:10505028 PMID:11260866 More...

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

calreticulin

treatment

protein:increased expression:blood serum (human)
human cells and recombinant gene in a mouse model

RGD

PMID:26314964 PMID:22083347 PMID:32161598 PMID:12215887 PMID:24111870

RGD:150520159, RGD:150521704, RGD:150521699, RGD:150521700, RGD:150521678

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

carbonic anhydrase 12

protein:increased expression:serum;

RGD

NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440

G

caspase 8

ClinVar Annotator: match by term: Lung cancer | ClinVar Annotator: match by term: Lung cancer, protection against

PMID:17450141 PMID:18305469 PMID:25741868

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

coiled-coil domain containing 116

DNA:SNP:promoter:rs3747093 (human)

RGD

NCBI chr11:83,842,707...83,850,607
Ensembl chr11:83,845,557...83,850,607

G

C-C motif chemokine ligand 22

disease_progression

RGD

NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400

G

cyclin G1

treatment

human cells in mouse model

RGD

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

CD164 molecule

exacerbates

protein:increased expression:lung (human)

RGD

NCBI chr20:45,024,051...45,035,628
Ensembl chr20:45,023,973...45,035,634

G

cell division cycle 73

exacerbates

mRNA:increased expression:lung (human)

NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656

G

cyclin-dependent kinase inhibitor 1B

disease_progression

protein:decreased expression:lung (rat)

RGD

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 1C

disease_progression

protein:decreased expression:lung (rat)
DNA:hypermethylation:promoter (rat)

RGD

PMID:20512841 PMID:20512841

RGD:152998913, RGD:152998913

NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048

G

CF transmembrane conductance regulator

susceptibility

DNA:deletion, SNP, haplotype: :p.F508del, rs10487372 (human)

RGD

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

chromodomain helicase DNA binding protein 4

ameliorates

DNA:missense mutation:CDS p.D140E (rs7479004) (human)
mRNA:increased expression:lung (human)

PMID:30031117 PMID:25407497

RGD:153323309, RGD:153323305

NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541

G

checkpoint kinase 2

ClinVar Annotator: match by term: Lung cancer, somatic

PMID:16883537 PMID:18484200 PMID:21244692 PMID:21618645 PMID:23318652 More...

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

cholinergic receptor nicotinic alpha 3 subunit

susceptibility
onset

associated with smoking; DNA:SNP::rs1051730(human)
ClinVar Annotator: match by term: Lung cancer susceptibility 2
DNA:SNP:exon 2: rs8040868(T>C) (human)
DNA:SNP: :rs6495309(human)
DNA:haplotype:promoter:rs6495309(human)
associated with smoking; DNA:SNP: :rs1051730(human)
DNA:SNP:cds:rs3743073(human)

OMIM
ClinVar
RGD

PMID:18385676 PMID:18385738 PMID:18385739 PMID:28492532 PMID:29993116 More...

RGD:150526806, RGD:151361155, RGD:151347536, RGD:151347534, RGD:151347455, RGD:151347454

NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 5 subunit

susceptibility

DNA:SNP::rs16969968 (human)
DNA:SNP:exon, intron:rs1051730, rs1847529 (human)
ClinVar Annotator: match by term: Lung cancer susceptibility 2
DNA:SNP:intron:rs17486278(human)
associated with smoking; DNA:SNP::rs16969968 (human)
DNA:haplotype:promoter

OMIM
ClinVar
RGD

PMID:18385738 PMID:18385739 PMID:18618000 PMID:19132693 PMID:19443489 More...

RGD:150524357, RGD:153297750, RGD:150527839, RGD:150526806, RGD:150524361

NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146

G

cholinergic receptor nicotinic alpha 7 subunit

disease_progression

DNA:CNV:: CNV-3956(human)

RGD

NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 4 subunit

susceptibility

DNA:SNP: :rs7178270(human)
DNA:SNP:3'utr: (rs1948)C>T (human)

RGD

PMID:20587604 PMID:29416783

RGD:150527839, RGD:151361155

NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027

G

CLPTM1-like

disease_progression
sexual_dimorphism
susceptibility

in males;DNA:SNP: :rs370348(human)
associated with smoking; DNA:SNP:intron:rs31489(human)
DNA:SNPs:: rs402710,rs451360 (human)
DNA:SNPs::multiple (human)

PMID:27062701 PMID:24366883 PMID:21771723 PMID:21622582 PMID:25422207 More...

RGD:150537097, RGD:150530483, RGD:150530643, RGD:150530642, RGD:150530631, RGD:150530494, RGD:150530484

NCBI chr 1:29,667,545...29,683,530
Ensembl chr 1:29,667,545...29,683,530

G

catechol-O-methyltransferase

susceptibility

associated with nicotine dependence and alcohol dependence; DNA:SNP:exon 4: 472G>A, p.V158M (rs4680) (human)

RGD

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

colony stimulating factor 1 receptor

susceptibility
exacerbates

DNA:missense mutation:CDS:p.H362R (rs10079250) (human)
protein:increased expression:lung (human)

RGD

PMID:25144241 PMID:29323162

RGD:150524283, RGD:150524284

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

catenin beta 1

treatment

human cells in mouse model

RGD

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome P450, family 1, subfamily a, polypeptide 1

associated with Pulmonary Emphysema;DNA:polymorphism: :p.I462V (human)

RGD

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 24, subfamily a, polypeptide 1

sexual_dimorphism

mRNA:increased expression:lung (human)
DNA:SNP:intron: (rs2765934) (human)

RGD

PMID:16180015 PMID:31264381

RGD:151361183, RGD:151665340

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

DAB adaptor protein 2

disease_progression

protein:decreased expression:lung (human)

RGD

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

DAB2 interacting protein

sexual_dimorphism

DNA:SNP:intron 1:97906C>A (rs1571801) (human)

RGD

NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280

G

diacylglycerol lipase, alpha

DNA:SNP:rs60507107 (human)

RGD

NCBI chr 1:206,890,635...206,947,332
Ensembl chr 1:206,890,638...206,947,232

G

dihydrofolate reductase

ClinVar Annotator: match by term: Lung cancer, somatic

NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713

G

dicer 1 ribonuclease III

exacerbates

RGD

NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965

G

dynein axonemal intermediate chain 7

ameliorates

DNA:missense mutation:CDS:p.N60S (mouse)

RGD

NCBI chr 4:178,143,499...178,179,871
Ensembl chr 4:178,143,500...178,179,980

G

DNA methyltransferase 1

disease_progression

protein:increased expression:lung:
protein:increased expression:lung (human)

RGD

PMID:24548441 PMID:21496867

RGD:9588658, RGD:150530293

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

DNA methyltransferase 3 alpha

disease_progression

protein:increased expression:lung:

RGD

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

DNA methyltransferase 3 beta

disease_progression

protein:increased expression:lung:

RGD

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

dishevelled segment polarity protein 3

DNA:SNP:intron:rs1969253 (human)

RGD

NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462

G

epidermal growth factor receptor

ClinVar Annotator: match by term: EGFR-related condition | ClinVar Annotator: match by term: EGFR-related lung cancer | ClinVar Annotator: match by term: Lung cancer | ClinVar Annotator: match by term: Lung cancer, somatic
ClinVar Annotator: match by term: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in, somatic | ClinVar Annotator: match by term: EGFR-related condition | ClinVar Annotator: match by term: EGFR-related lung cancer | ClinVar Annotator: match by term: Lung cancer | ClinVar Annotator: match by term: Lung cancer, somatic

PMID:7630400 PMID:9536098 PMID:11423618 PMID:15118073 PMID:15118125 More...

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

erb-b2 receptor tyrosine kinase 2

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

ERCC excision repair 5, endonuclease

susceptibility

mRNA:decreased expression:lung (human)

RGD

NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472

G

ERCC excision repair 6, chromatin remodeling factor

susceptibility
disease_progression
no_association

DNA:point mutation:promoter::c.-6530C>G (rs3793784) (human)
ClinVar Annotator: match by term: LUNG CANCER, SUSCEPTIBILITY TO | ClinVar Annotator: match by term: Lung cancer | ClinVar Annotator: match by term: Lung cancer, somatic
mRNA:decreased expression:lung (human)
DNA:SNPs: :p.G399D, p.Q1413R (human)
DNA:SNPs: :multiple

OMIM
ClinVar
RGD

PMID:9443879 PMID:10767341 PMID:16754848 PMID:17854076 PMID:18414213 More...

RGD:11561791, RGD:155260338, RGD:11567235, RGD:11567231

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

establishment of sister chromatid cohesion N-acetyltransferase 2

severity

RGD

NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

susceptibility

DNA:SNPs, haplotype: :rs6950683, rs3757441 (human)

RGD

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

Fas cell surface death receptor

ClinVar Annotator: match by term: LUNG CANCER, SUSCEPTIBILITY TO

PMID:15937082 PMID:25741868

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

susceptibility

ClinVar Annotator: match by term: Lung cancer, somatic

PMID:17605793 PMID:25741868 PMID:28492532

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fibroblast growth factor 9

OMIM:211980 | OMIM:608935 | OMIM:612571 | OMIM:612593 | OMIM:614210

NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309

G

forkhead box A1

disease_progression

RGD

NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188

G

forkhead box M1

OMIM:211980 | OMIM:608935 | OMIM:612571 | OMIM:612593 | OMIM:614210

NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684

G

GATA binding protein 1

mRNA:increased expression:regulatory T cell:lung associated T cell

RGD

NCBI chr X:14,529,706...14,537,530
Ensembl chr X:14,529,702...14,537,530

G

glutathione peroxidase 1

susceptibility
exacerbates

DNA:missense mutation:CDS:p.P198L (human)
DNA:missense mutation:CDS: (rs1050450) (human)
DNA:mutations:multiple (human)

RGD

PMID:16615267 PMID:23516596 PMID:15192016 PMID:32850411 PMID:11103801

RGD:152023634, RGD:152998903, RGD:152995506, RGD:152995450, RGD:152995449

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 3

treatment

RGD

PMID:33255360 PMID:26767034

RGD:151708705, RGD:151708707

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glutathione S-transferase mu 1

resistance

RGD

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase theta 1

susceptibility

DNA:deletion: :

RGD

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

heterogeneous nuclear ribonucleoprotein L

severity

human gene in a mouse model

RGD

NCBI chr 1:84,098,558...84,111,568
Ensembl chr 1:84,100,879...84,111,553

G

haptoglobin

RGD

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

heparan sulfate-glucosamine 3-sulfotransferase 2

DNA:hypermethylation:promoter (human)

RGD

NCBI chr 1:175,956,161...176,077,400
Ensembl chr 1:175,956,157...176,077,399

G

isocitrate dehydrogenase (NADP(+)) 2

RGD

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

interleukin 1 receptor type 2

susceptibility

DNA:SNP:CDS:multiple (human)

RGD

NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725

G

interferon regulatory factor 1

NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166

G

insulin receptor substrate 4

treatment

human cells in mouse model

RGD

NCBI chr X:105,344,020...105,360,004

G

lysine demethylase 4A

protein:increased expression:lung (human)

RGD

NCBI chr 5:131,672,754...131,719,534
Ensembl chr 5:131,672,754...131,719,501

G

lysine demethylase 4B

mRNA, protein:increased expression:lung (human)

RGD

NCBI chr 9:1,158,737...1,237,233
Ensembl chr 9:1,158,752...1,236,543

G

lysine demethylase 6A

exacerbates

RGD

NCBI chr X:4,337,466...4,477,100
Ensembl chr X:4,337,750...4,477,062

G

lysine methyltransferase 2D

ClinVar Annotator: match by term: Lung cancer

NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325

G

KRAS proto-oncogene, GTPase

OMIM:211980 | OMIM:608935 | OMIM:612571 | OMIM:612593 | OMIM:614210
ClinVar Annotator: match by term: Lung cancer, somatic
protein:increased expression:lung (human)

MouseDO
ClinVar
OMIM
RGD

PMID:6320174 PMID:11745231 PMID:12110640 PMID:12460918 PMID:14982869 More...

NCBI chr 4:178,185,418...178,218,484

G

LDL receptor related protein 1B

severity

DNA:mutations: :multiple (human)

RGD

NCBI chr 3:24,594,302...26,715,037
Ensembl chr 3:24,594,991...26,715,505

G

mitogen activated protein kinase kinase 4

ameliorates

DNA:SNP:promoter: -1304T>G (rs3826392) (human)

RGD

NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993

G

mitogen-activated protein kinase kinase kinase 8

exacerbates

OMIM
RGD

NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216

G

methionine adenosyltransferase 2A

treatment

human cells in mouse model

RGD

NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493

G

methyl-CpG binding domain protein 1

susceptibility

DNA:snps, deletion:promoter, cds:g.-634G>A, g.-501delT, p.P401A (human)
DNA:snp::c.1221+135T>A (rs140689) (human)

RGD

PMID:16284366 PMID:18668384

RGD:9588651, RGD:9588657

NCBI chr18:67,869,870...67,884,501
Ensembl chr18:67,869,992...67,886,554

G

methyl-CpG binding domain 4 DNA glycosylase

susceptibility

DNA:snp:cds:p.E346K (rs140693) (human)

RGD

NCBI chr 4:148,893,049...148,904,833
Ensembl chr 4:148,894,280...148,904,982

G

mannose binding lectin 2

susceptibility

DNA:polymorphisms:multiple (human)

RGD

NCBI chr 1:228,016,439...228,024,736

G

MCL1 apoptosis regulator, BCL2 family member

ameliorates

human cells in mouse model
DNA:SNP:promoter:-190indel, -235C>A, (rs3831987,rs3738484)
protein:increased expression:lung (human)

RGD

PMID:31662324 PMID:21887682 PMID:28776569

RGD:151356915, RGD:151356991, RGD:151356930

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

myocyte enhancer factor 2D

treatment

human cells in mouse model

RGD

NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457

G

microRNA 122

treatment

human cells in mouse model

RGD

NCBI chr18:58,758,703...58,758,787

G

microRNA 127

RNA:increased expression:lung (human)

NCBI chr 6:128,546,215...128,546,311
Ensembl chr 6:128,546,215...128,546,311

G

microRNA 136

ameliorates

RNA:increased expression:lung (human)
human cells in mouse model

PMID:20237410 PMID:34258296

RGD:152995484, RGD:153350142

NCBI chr 6:128,549,096...128,549,177
Ensembl chr 6:128,549,096...128,549,177

G

microRNA 152

miRNA:increased expression:plasma

RGD

NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020

G

microRNA 193a

ameliorates
treatment

human cells in mouse model
DNA:hypermethylation

RGD

PMID:27821145 PMID:27669434 PMID:35289739 PMID:29183007

RGD:153344578, RGD:153344606, RGD:153344587, RGD:153344580

NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454

G

microRNA 205

RNA:increased expression:lung (human)

NCBI chr13:105,035,878...105,035,985
Ensembl chr13:105,035,878...105,035,985

G

microRNA 21

ameliorates

RNA:increased expression:blood serum (human)

RGD

PMID:22638884 PMID:22618808

RGD:152998900, RGD:152998905

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 222

ameliorates

RGD

NCBI chr X:3,428,904...3,429,006
Ensembl chr X:3,428,904...3,429,006

G

microRNA 31

disease_progression

RNA:increased expression:peripheral blood mononuclear cell (human)
RNA:increased expression:lung (human)

PMID:20237410 PMID:25765717

RGD:152995484, RGD:152998919

NCBI chr 5:103,599,038...103,599,143

G

microRNA 337

RNA:increased expression:lung (human)

NCBI chr 6:128,538,903...128,538,999
Ensembl chr 6:128,538,902...128,538,998

G

microRNA 410

RNA:increased expression:lung (human)

NCBI chr 6:128,758,358...128,758,433
Ensembl chr 6:128,758,354...128,758,434

G

microRNA 431

RNA:increased expression:lung (human)

NCBI chr 6:128,544,210...128,544,323
Ensembl chr 6:128,544,210...128,544,323

G

microRNA 98

treatment

RGD

NCBI chr X:20,981,235...20,981,342
Ensembl chr X:20,981,235...20,981,342

G

Mirlet7b host gene

susceptibility

DNA:SNPs:multiple

RGD

G

marker of proliferation Ki-67

ameliorates

human cells in mouse model

RGD

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

mutL homolog 1

susceptibility
no_association

DNA:SNP:promoter:-93A>G (rs1800734) (human)
ClinVar Annotator: match by term: Lung cancer
DNA:SNP: :rs1800734 (human)
DNA:SNP: :9452A>T (rs1540354) (human)

PMID:25420488 PMID:26845104 PMID:28492532 PMID:30702970 PMID:21093954 More...

RGD:126848792, RGD:126848798, RGD:126848792

NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617

G

matrix metallopeptidase 1

susceptibility

DNA:insertion, haplotype:promoter:g.-1607insG (human)
DNA:insertion:promoter:g.-1607insG (human)
associated with Respiratory Tract Diseases

RGD

PMID:19963114 PMID:11691799 PMID:15718477

RGD:4890379, RGD:7207021, RGD:5131088

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 3

protein:decreased expression:pleural fluid

RGD

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

myeloperoxidase

associated with Respiratory Tract Diseases
ClinVar Annotator: match by term: Lung cancer, protection against, in smokers

PMID:11087769 PMID:12915675 PMID:15023809 PMID:17304047 PMID:15718477

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

myelin protein zero-like 3

DNA:SNP:UTR3:rs11216826 (human)

RGD

NCBI chr 8:45,360,475...45,380,662
Ensembl chr 8:45,349,054...45,380,662

G

mutS homolog 2

susceptibility

DNA:SNP: :rs2303425 (human)

RGD

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

mutS homolog 3

ClinVar Annotator: match by term: Lung cancer, somatic

NCBI chr 2:23,444,326...23,585,777

G

MYC proto-oncogene, bHLH transcription factor

treatment

human cells in mouse model

RGD

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYD88, innate immune signal transduction adaptor

exacerbates

human cell line in a mouse model

RGD

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

N-acetyltransferase 2

no_association
susceptibility

DNA:polymorphisms: :

RGD

PMID:15808403 PMID:19558213

RGD:5131861, RGD:5131605

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

nuclear receptor coactivator 6

DNA:amplification:cds (human)

RGD

NCBI chr 3:143,890,896...143,961,916
Ensembl chr 3:143,890,896...143,952,268

G

NFE2 like bZIP transcription factor 2

ClinVar Annotator: match by term: Lung cancer

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

disease_progression
exacerbates

RGD

PMID:26300007 PMID:26300007

RGD:11535492, RGD:11535492

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

susceptibility

DNA:polymorphisms:promoter:-826C>T,-881A>G (human)

RGD

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nucleotide-binding oligomerization domain containing 2

susceptibility

DNA:insertion: : 3020_3021insC (human)

RGD

NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177

G

partner and localizer of BRCA2

ClinVar Annotator: match by term: Lung cancer, somatic

PMID:17200668 PMID:17200671 PMID:17200672 PMID:24136930 PMID:25099575 More...

NCBI chr 1:176,665,076...176,689,053
Ensembl chr 1:176,665,076...176,688,990

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

ClinVar Annotator: match by term: EGFR-related lung cancer

PMID:19366826 PMID:25157968 PMID:25741868 PMID:26619011

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phospholipase C, gamma 1

exacerbates

RGD

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

PML nuclear body scaffold

ameliorates

RGD

NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971

G

DNA polymerase epsilon, catalytic subunit

severity

DNA:missense mutation:CDS:p.A252V (human)

RGD

NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939

G

protection of telomeres 1

DNA:SNP: : rs10244817 (human)
DNA:SNP: :rs116895242 (human)
DNA:SNP: :p.V326A (rs75932146) (human)

RGD

PMID:19285750 PMID:27459707 PMID:32514122

RGD:151356947, RGD:151356949, RGD:151356948

NCBI chr 4:54,205,330...54,263,137
Ensembl chr 4:54,205,332...54,263,042