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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Picornaviridae Infections
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Accession:DOID:9003470 term browser browse the term
Definition:Virus diseases caused by the PICORNAVIRIDAE.
Synonyms:exact_synonym: Picornaviridae Infection;   Picornavirus Infection;   Picornavirus Infections
 primary_id: MESH:D010850
 xref: EFO:0007438


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Picornaviridae Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl11 C-C motif chemokine ligand 11 ISO associated with Asthma RGD PMID:20644177 RGD:4140459 NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Cd1d1 CD1d1 molecule treatment ISO RGD PMID:16809320 PMID:19949077 RGD:127345105, RGD:127345106 NCBI chr 2:174,721,522...174,725,029
Ensembl chr 2:172,423,582...172,427,089 		JBrowse link
G Il13 interleukin 13 ISO associated with Pulmonary Disease, Chronic Obstructive;mRNA,protein:increased expression:lung RGD PMID:19748999 RGD:4145626 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il25 interleukin 25 ISO mRNA, protein:increased expression:lung
protein:increased expression:nasal mucus		 RGD PMID:25273095 PMID:25273095 RGD:39128256, RGD:39128256 NCBI chr15:32,378,750...32,382,141
Ensembl chr15:28,408,842...28,411,893 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming severity ISO protein:increased expression:lung
associated with Pulmonary Disease, Chronic Obstructive		 RGD PMID:20525715 PMID:19748999 RGD:5131431, RGD:4145626 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Tnf tumor necrosis factor ISO associated with Pulmonary Disease, Chronic Obstructive;mRNA,protein:increased expression:lung RGD PMID:19748999 RGD:4145626 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tslp thymic stromal lymphopoietin ISO protein:increased expression:lung (mouse)
mRNA, protein:increased expression:lung,bronchoalveolar lavage fluid (mouse) 		RGD PMID:28701507 PMID:26100084 RGD:38596334, RGD:11085671 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
Cardiovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 ISO encephalomyocarditis virus;mRNA, protein:decreased expression, increased expression:heart (mouse) RGD PMID:19453650 RGD:40818405 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 ISO RGD PMID:21636578 RGD:40902809 NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:16,188,979...16,224,971 		JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 susceptibility IMP RGD PMID:27999109 PMID:27999109 RGD:12910492, RGD:12910492 NCBI chr11:44,211,769...44,238,206
Ensembl chr11:30,725,790...30,749,979 		JBrowse link
G Ifnar1em1 interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 1 IMP RGD PMID:27999109 RGD:12910492
G Ifnar1em2 interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 2 IMP RGD PMID:27999109 RGD:12910492
G Il33 interleukin 33 ISO mRNA:increased expression:brain: RGD PMID:18552204 RGD:40400716 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Pde12 phosphodiesterase 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26055709 NCBI chr16:1,926,807...1,932,383
Ensembl chr16:1,915,386...1,925,887 		JBrowse link
G Rnasel ribonuclease L ISO RGD PMID:21636578 RGD:40902809 NCBI chr13:68,446,641...68,460,804
Ensembl chr13:65,901,459...65,908,704 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:10609881 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
common cold term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase ISO protein:increased expression:bronchus RGD PMID:11865407 RGD:4890421 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein ISO protein:increased expression:bronchus RGD PMID:11865407 RGD:4890421 NCBI chr12:10,785,254...10,809,295
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:20696083 RGD:4140458 NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 ISO associated with Pulmonary Disease, Chronic Obstructive;protein:increased expression:respiratory epithelial cell RGD PMID:20395558 RGD:4145446 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:15764644 RGD:5135489 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 ISO associated with Pulmonary Disease, Chronic Obstructive;protein:increased expression:respiratory epithelial cell RGD PMID:20395558 RGD:4145446 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 ISO associated with Asthma RGD PMID:12751040 RGD:5135264 NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,310,426...17,313,093 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 ISO RGD PMID:19864593 RGD:5131210 NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Defb4 defensin beta 4 ISO mRNA, protein:increased expression:nasal cavity epithelium, nasal mucus RGD PMID:15034083 RGD:4892264 NCBI chr16:77,352,911...77,356,104
Ensembl chr16:70,650,472...70,653,665 		JBrowse link
G Defb5 defensin beta 5 ISO mRNA, protein:increased expression:nasal cavity epithelium, nasal mucus RGD PMID:15034083 RGD:4892264 NCBI chr16:77,315,424...77,317,828
Ensembl chr16:70,613,146...70,615,467 		JBrowse link
G Ifna2 interferon alpha 2 treatment ISO RGD PMID:6381610 RGD:40886344 NCBI chr 5:103,258,617...103,259,195 JBrowse link
G Il10 interleukin 10 ISO RGD PMID:20696083 RGD:4140458 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1a interleukin 1 alpha ISO protein:increased expression:nasal mucus RGD PMID:10358201 RGD:4143183 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:nasal mucus RGD PMID:7734976 RGD:7401200 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO protein:increased expression:nasal mucus RGD PMID:18279051 PMID:10358201 RGD:4143207, RGD:4143183 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il33 interleukin 33 ISO protein:increased expression:nasal mucus RGD PMID:28471975 RGD:38596342 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il4 interleukin 4 ISO associated with Asthma;mRNA, protein:increased expression:alveolar macrophage, respiratory system fluid/secretion RGD PMID:20644177 RGD:4140459 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Prdx5 peroxiredoxin 5 ISO associated with asthma;protein:increased expression:sputum (human) RGD PMID:18219526 RGD:41404684 NCBI chr 1:213,529,042...213,532,787
Ensembl chr 1:204,099,826...204,114,268 		JBrowse link
G Tslp thymic stromal lymphopoietin ISO protein:increased expression:nasal mucus (human) RGD PMID:28471975 RGD:38596342 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
Coxsackievirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cast calpastatin ISO CTD Direct Evidence: therapeutic CTD PMID:34365571 NCBI chr 2:5,707,633...5,817,213
Ensembl chr 2:3,973,112...4,082,659 		JBrowse link
G Cd1d1 CD1d1 molecule ISO protein:increased expression:spleen, mononuclear cell (mouse) RGD PMID:16817758 RGD:127345109 NCBI chr 2:174,721,522...174,725,029
Ensembl chr 2:172,423,582...172,427,089 		JBrowse link
G Cd274 CD274 molecule treatment ISO RGD PMID:30904424 RGD:40818421 NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Dnm1l dynamin 1-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:34365571 NCBI chr11:98,084,049...98,135,663
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25396421 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 treatment ISO RGD PMID:30904424 RGD:40818421 NCBI chr 1:236,572,497...236,637,490
Ensembl chr 1:227,158,941...227,223,938 		JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16683188 NCBI chr 6:137,526,416...137,530,790
Ensembl chr 6:131,705,323...131,709,690 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21641380 NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21641380 NCBI chr10:38,634,098...38,687,409
Ensembl chr10:38,133,322...38,179,720 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21641380 NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25396421 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11745696 NCBI chr 5:82,266,436...82,292,858
Ensembl chr 5:77,251,373...77,277,421 		JBrowse link
G Tnfsf9 TNF superfamily member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11745696 NCBI chr 9:2,031,011...2,033,345
Ensembl chr 9:1,944,017...1,946,345 		JBrowse link
Enterovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btk Bruton tyrosine kinase treatment ISO Associated with X-linked agammaglobulinemia RGD PMID:10508272 RGD:124715472 NCBI chr  X:102,016,070...102,055,448
Ensembl chr  X:97,722,802...97,761,853 		JBrowse link
G Cog1 component of oligomeric golgi complex 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr10:98,695,481...98,708,495
Ensembl chr10:98,695,423...98,709,292 		JBrowse link
G Cog5 component of oligomeric golgi complex 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr 6:48,242,470...48,545,185
Ensembl chr 6:48,242,482...48,529,009 		JBrowse link
G Il10 interleukin 10 severity ISO DNA:SNP:promoter:-592A>C (rs1800872) (human) RGD PMID:28843383 RGD:14975146 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Mgat5 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr13:38,675,776...38,959,697
Ensembl chr13:38,676,119...38,959,513 		JBrowse link
G Mir146a microRNA 146a ameliorates ISO miRNA:increased expression:blood serum, exosome (human) RGD PMID:28910400 PMID:24561744 RGD:126925164, RGD:126925173 NCBI chr10:28,349,996...28,350,090
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mx1 MX dynamin like GTPase 1 susceptibility ISO DNA:SNPs:promoter:g.-123C>A, g.-88G>T (rs17000900, rs2071430) (human) RGD PMID:24085612 RGD:126777678 NCBI chr11:50,269,056...50,294,699
Ensembl chr11:36,799,660...36,823,507 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21641380 NCBI chr10:38,634,098...38,687,409
Ensembl chr10:38,133,322...38,179,720 		JBrowse link
G St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr 7:100,734,300...100,802,443
Ensembl chr 7:98,845,270...98,913,236 		JBrowse link
G St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr 8:41,673,510...41,723,158
Ensembl chr 8:33,415,671...33,524,389 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO Rhinovirus Infections RGD PMID:19864593 RGD:5131210 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
hand, foot and mouth disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta ISO protein:increased expression:serum RGD PMID:30817906 RGD:36947391 NCBI chr12:16,776,664...16,779,634
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Ren renin treatment ISO RGD PMID:31638922 RGD:127285374 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
hepatitis A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO DNA:insertion/deletion:intron 16: RGD PMID:12458570 RGD:39939119 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 disease_progression ISO RGD PMID:26347518 RGD:40818419 NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:62,319,312...62,324,963 		JBrowse link
G Pdcd1 programmed cell death 1 disease_progression ISO RGD PMID:26347518 RGD:40818419 NCBI chr 9:101,866,124...101,879,278
Ensembl chr 9:94,418,791...94,431,937 		JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:serum (human) RGD PMID:9047083 RGD:14995307 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO DNA:missense mutation:cds:p.R194W (rs1799782) (human)
DNA:SNP:intron: (rs1001581) (human)		 RGD PMID:22135187 PMID:29558945 RGD:15014793, RGD:15036793 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
Keshan disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 ISO mRNA,protein:increased expression:blood cells, serum: RGD PMID:26893848 RGD:124713562 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 ISO mRNA,protein:increased expression:blood cells, serum: RGD PMID:26893848 RGD:124713562 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO DNA:polymorphism: :p.P198L (human) RGD PMID:21055077 RGD:11352821 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
poliomyelitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pvr PVR cell adhesion molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:3020560 PMID:28446605 NCBI chr 1:88,689,235...88,704,641
Ensembl chr 1:79,546,879...79,576,715 		JBrowse link
vestibular neuronitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein disease_progression ISO RGD PMID:14636287 RGD:9491594 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19140
    disease by infectious agent 2255
      viral infectious disease 1719
        RNA Virus Infections 1400
          Picornaviridae Infections 65
            Cardiovirus Infections 11
            Enterovirus Infections + 34
            Foot-and-Mouth Disease 0
            common cold 19
paths to the root