RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Body Weight Changes
Accession: DOID:9003287
browse the term
Definition: A clinical manifestation consisting of alterations in an individual's weight from his or her norm.
Synonyms: exact_synonym: Body Weight Change
primary_id: MESH:D001836
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Lep
leptin
IMP
RGD
PMID:21328617
RGD:5128513
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Atp2a1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
IEP
associated with hepatocellular carcinoma
RGD
PMID:23200745
RGD:13782066
NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
IEP
associated with hepatocellular carcinoma
RGD
PMID:23200745
RGD:13782066
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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Azgp1
alpha-2-glycoprotein 1, zinc-binding
ISO
associated with gastrointestinal system cancer;mRNA,protein:increased expression:subcutaneous adipose tissue:
RGD
PMID:21245862
RGD:153350145
NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091
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Bard1
BRCA1 associated RING domain 1
IEP
associated with Carcinoma, Hepatocellular;protein:increased expression:skeletal muscle
RGD
PMID:16685375
RGD:2315732
NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265
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Cd27
CD27 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17878525
NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592
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Cdh6
cadherin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17878525
NCBI chr 2:62,079,139...62,225,298
Ensembl chr 2:62,079,137...62,225,228
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Cebpb
CCAAT/enhancer binding protein beta
treatment
ISO
RGD
PMID:27122162
RGD:40903021
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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Coq7
coenzyme Q7, hydroxylase
susceptibility
ISO
RGD
PMID:23166727
RGD:10402105
NCBI chr 1:172,836,359...172,851,173
Ensembl chr 1:172,835,188...172,851,158
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Ddx42
DEAD-box helicase 42
IEP ISO
associated with Diabetes Mellitus, Experimental;mRNA:increased expression:gastrocnemius muscle (rat) associated with Malnutrition;mRNA:increased expression:gastrocnemius muscle (mouse)
RGD
PMID:14718385 PMID:14718385
RGD:1641826 , RGD:1641826
NCBI chr10:91,148,926...91,180,940
Ensembl chr10:91,148,254...91,180,939
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Gdf15
growth differentiation factor 15
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30782979
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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Ghrl
ghrelin and obestatin prepropeptide
ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:17347304 PMID:12576449
RGD:7242556
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
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Igf1
insulin-like growth factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30782979
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Il1b
interleukin 1 beta
IDA
associated with Inflammation
RGD
PMID:15005009
RGD:1626680
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il1rn
interleukin 1 receptor antagonist
IDA
associated with Inflammation
RGD
PMID:15005009
RGD:1626680
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Il6
interleukin 6
IEP ISO
associated with Leukemia, T-Cell;protein:increased activity:plasma (rat) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:17878525 PMID:9110147
RGD:11062106
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Jak2
Janus kinase 2
treatment
ISO
associated with colon adenocarcinoma
RGD
PMID:28489606
RGD:127285673
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Lpin1
lipin 1
IEP
associated with Carcinoma, Hepatocellular;mRNA:increased expression:skeletal muscle
RGD
PMID:14718385
RGD:1641826
NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
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Lta
lymphotoxin alpha
susceptibility
ISO
associated with Breast Neoplasms;DNA:polymorphism:intron:252G>A (human)
RGD
PMID:18953879
RGD:8548798
NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
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Map3k7
mitogen activated protein kinase kinase kinase 7
treatment
IMP
associated with Pulmonary Arterial Hypertension
RGD
PMID:30554141
RGD:155791671
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
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Mc4r
melanocortin 4 receptor
ISO
associated with Myocardial Infarction
RGD
PMID:20371568
RGD:6484229
NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
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Mefv
MEFV innate immunity regulator, pyrin
ISO
ClinVar Annotator: match by term: Cachexia
ClinVar
PMID:9668175 PMID:10090880 PMID:10612841 PMID:10787450 PMID:10842288 PMID:11464238 PMID:11977178 PMID:15018633 PMID:15024744 PMID:16730661 PMID:17489852 PMID:19253030 PMID:19934083 PMID:20041150 PMID:20534143 PMID:21246368 PMID:21413889 PMID:21978701 PMID:22614345 PMID:22903357 PMID:23505242 PMID:23588594 PMID:23907647 PMID:23981758 PMID:24251727 PMID:24469716 PMID:24929125 PMID:25615955 PMID:25741868 PMID:26078663 PMID:28492532 PMID:29047407 PMID:29543225 PMID:29599418 PMID:31989427 PMID:32312770 PMID:33733382 PMID:34426522 PMID:35098403 More...
NCBI chr10:11,786,948...11,796,977
Ensembl chr10:11,787,422...11,796,973
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Mstn
myostatin
IEP
associated with Carcinoma, Hepatocellular;mRNA:increased expression:skeletal muscle
RGD
PMID:18578694
RGD:2303552
NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933
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Myd88
MYD88, innate immune signal transduction adaptor
ameliorates
ISO
associated with Carcinoma, Lewis Lung
RGD
PMID:31138662
RGD:150530282
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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Parl
presenilin associated, rhomboid-like
ISO
RGD
PMID:16839884
RGD:12902627
NCBI chr11:80,594,059...80,620,506
Ensembl chr11:80,593,192...80,620,506
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Ppara
peroxisome proliferator activated receptor alpha
ISO
associated with Pulmonary Disease, Chronic Obstructive (COPD, MeSH:D029424); RNA:decreased expression:skeletal muscle (human)
RGD
PMID:17459894
RGD:5683621
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17878525
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Pthlh
parathyroid hormone-like hormone
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17878525
NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
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Slc25a4
solute carrier family 25 member 4
IEP
associated with hepatocellular carcinoma
RGD
PMID:23200745
RGD:13782066
NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
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Tfam
transcription factor A, mitochondrial
ISO
associated with Pulmonary Disease, Chronic Obstructive (COPD, MeSH:D029424); RNA, protein:decreased expression:skeletal muscle (human)
RGD
PMID:17459894
RGD:5683621
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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Tgfb1
transforming growth factor, beta 1
ISO
RGD
PMID:2054795
RGD:7394820
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf
tumor necrosis factor
ISO IEP
CTD Direct Evidence: marker/mechanism associated with hepatocellular carcinoma;mRNA:altered expression:skeletal muscle tissue, adipose tissue (rat)
CTD RGD
PMID:17878525 PMID:16077938
RGD:1624190
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf1a
TNF receptor superfamily member 1A
IEP ISO
associated with Carcinoma, Hepatocellular;protein, mRNA:increased expression:skeletal muscle, adipose tissue CTD Direct Evidence: therapeutic
CTD RGD
PMID:18801959 PMID:16077938
RGD:1624190
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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Zfp36
zinc finger protein 36
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12756304 PMID:15944294
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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Mgme1
mitochondrial genome maintenance exonuclease 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23313956
NCBI chr 3:131,640,770...131,649,933
Ensembl chr 3:131,640,944...131,649,932
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Abcg1
ATP binding cassette subfamily G member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17194745
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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Acadm
acyl-CoA dehydrogenase medium chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
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Ace
angiotensin I converting enzyme
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25322899
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Adipoq
adiponectin, C1Q and collagen domain containing
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12860835
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Ahr
aryl hydrocarbon receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27020609 PMID:30813227 PMID:31306034 PMID:36029422
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Akr1c2
aldo-keto reductase family 1, member C2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25322899
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Anxa2
annexin A2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
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Anxa5
annexin A5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
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Apbb2
amyloid beta precursor protein binding family B member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr14:41,557,918...41,878,622
Ensembl chr14:41,557,972...41,877,495
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App
amyloid beta precursor protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Arhgef12
Rho guanine nucleotide exchange factor 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 8:43,350,070...43,475,404
Ensembl chr 8:43,353,799...43,476,366
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Asip
agouti signaling protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:37769864
NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171
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Bcat1
branched chain amino acid transaminase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
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Calm1
calmodulin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
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Cav1
caveolin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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Cavin1
caveolae associated protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr10:85,884,100...85,896,136
Ensembl chr10:85,889,036...85,896,120
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Cd36
CD36 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Clic4
chloride intracellular channel 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452
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Cnr1
cannabinoid receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20107430
NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
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Copg2
COPI coat complex subunit gamma 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 4:59,366,086...59,501,591
Ensembl chr 4:59,366,086...59,501,618
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Cpe
carboxypeptidase E
ISO
associated with kidney transplant;DNA:SNP:CDS (rs1946816) (human)
RGD
PMID:26406335
RGD:405650673
NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
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Ctsd
cathepsin D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19997080
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Ddo
D-aspartate oxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16525061
NCBI chr20:44,090,823...44,109,962
Ensembl chr20:44,090,914...44,133,095
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Dnah11
dynein, axonemal, heavy chain 11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 6:138,839,175...139,155,554
Ensembl chr 6:138,839,177...139,155,536
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Drd2
dopamine receptor D2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20375926
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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Dync1li2
dynein, cytoplasmic 1 light intermediate chain 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670
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Ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30971429
NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
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Fbln2
fibulin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 4:123,704,289...123,763,857
Ensembl chr 4:123,704,373...123,763,948
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Fbxo21
F-box protein 21
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr12:38,570,878...38,605,133
Ensembl chr12:38,571,023...38,605,133
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Fez2
fasciculation and elongation protein zeta 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 6:16,654,572...16,694,628
Ensembl chr 6:16,654,614...16,694,626
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Fgf1
fibroblast growth factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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Fggy
FGGY carbohydrate kinase domain containing
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29220483
NCBI chr 5:110,398,866...110,786,019
Ensembl chr 5:110,398,863...110,786,017
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Fstl1
follistatin-like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677
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Fto
FTO, alpha-ketoglutarate dependent dioxygenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25322899
NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083
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Gdf15
growth differentiation factor 15
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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Gh1
growth hormone 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17372281
NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
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Ghrl
ghrelin and obestatin prepropeptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16493877 PMID:33301842
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
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Gnb3
G protein subunit beta 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16141801
NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173
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Gpr55
G protein-coupled receptor 55
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30148676
NCBI chr 9:86,584,906...86,640,601
Ensembl chr 9:86,590,885...86,640,613
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Grb14
growth factor receptor bound protein 14
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889
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Gsn
gelsolin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
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Hcrt
hypocretin neuropeptide precursor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27071101
NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210
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Hdhd2
haloacid dehalogenase-like hydrolase domain containing 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr18:70,488,315...70,526,471
Ensembl chr18:70,474,926...70,526,470
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Htr2c
5-hydroxytryptamine receptor 2C
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19434072 PMID:19997080
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
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Hycc2
hyccin PI4KA lipid kinase complex subunit 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 9:60,056,883...60,129,176
Ensembl chr 9:60,056,890...60,093,007
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Ido1
indoleamine 2,3-dioxygenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27020609
NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
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Igfbp5
insulin-like growth factor binding protein 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
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Il7
interleukin 7
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20376352
NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
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Insig2
insulin induced gene 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18195716 PMID:20373477
NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
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Iqgap1
IQ motif containing GTPase activating protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755
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Kcnma1
potassium calcium-activated channel subfamily M alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27605626
NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198
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Kcnmb1
potassium calcium-activated channel subfamily M regulatory beta subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27288421
NCBI chr10:18,557,510...18,614,824
Ensembl chr10:18,557,904...18,565,798
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Large1
LARGE xylosyl- and glucuronyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr19:11,603,129...12,048,930
Ensembl chr19:11,603,129...12,048,930
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Lbp
lipopolysaccharide binding protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
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Lep
leptin
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:15070752 PMID:15809509 PMID:17502770 PMID:19716478 PMID:21561152 PMID:25086370 PMID:27472835 PMID:29967158 More...
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lepr
leptin receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15809509 PMID:29143802 PMID:29988851 PMID:36066211 PMID:36880193
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Lpgat1
lysophosphatidylglycerol acyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr13:103,294,622...103,365,372
Ensembl chr13:103,294,528...103,362,333
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Map4
microtubule-associated protein 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 8:109,925,233...110,064,370
Ensembl chr 8:109,925,575...110,064,362
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Mapre1
microtubule-associated protein, RP/EB family, member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 3:142,218,846...142,246,990
Ensembl chr 3:142,212,955...142,246,983
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Mapt
microtubule-associated protein tau
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29203278
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Me1
malic enzyme 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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Mest
mesoderm specific transcript
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 4:59,354,445...59,364,919
Ensembl chr 4:59,354,447...59,366,145
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Metrnl
meteorin-like, glial cell differentiation regulator
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:30213948
NCBI chr10:106,963,880...106,977,875
Ensembl chr10:106,963,880...106,977,869
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Mir21
microRNA 21
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:26996129
NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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Mmp12
matrix metallopeptidase 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
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Mmp2
matrix metallopeptidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25322899
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mprip
myosin phosphatase Rho interacting protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr10:44,453,949...44,573,843
Ensembl chr10:44,453,929...44,569,118
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Mrtfa
myocardin related transcription factor A
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:33779332
NCBI chr 7:112,544,305...112,714,418
Ensembl chr 7:112,544,312...112,714,418
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Myo10
myosin X
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 2:76,100,989...76,305,619
Ensembl chr 2:76,100,987...76,303,030
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Myo1b
myosin Ib
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798
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Ndc1
NDC1 transmembrane nucleoporin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 5:122,155,992...122,202,295
Ensembl chr 5:122,155,967...122,202,291
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Ndufb9
NADH:ubiquinone oxidoreductase subunit B9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 7:90,480,948...90,487,367
Ensembl chr 7:90,436,621...90,488,009
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Nek7
NIMA-related kinase 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr13:50,022,212...50,149,374
Ensembl chr13:50,022,218...50,149,296
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Nid1
nidogen 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr17:86,085,133...86,158,272
Ensembl chr17:86,085,077...86,158,267
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Npr3
natriuretic peptide receptor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
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Nus1
NUS1 dehydrodolichyl diphosphate synthase subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33812996
NCBI chr20:31,811,817...31,838,562
Ensembl chr20:31,811,817...31,838,561
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Osbpl8
oxysterol binding protein-like 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 7:46,596,944...46,749,888
Ensembl chr 7:46,596,983...46,749,888
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Oxt
oxytocin/neurophysin I prepropeptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18562099
NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
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Pakap
paralemmin A kinase anchor protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 5:72,536,986...72,648,524 NCBI chr 5:72,313,646...72,450,645
Ensembl chr 5:72,181,718...72,648,524
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Palld
palladin, cytoskeletal associated protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337
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Pcyox1
prenylcysteine oxidase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 4:118,832,114...118,842,951
Ensembl chr 4:118,830,638...118,842,951
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
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Pomc
proopiomelanocortin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:4367732 PMID:6143199
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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Ppard
peroxisome proliferator-activated receptor delta
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20176998
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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Prkd3
protein kinase D3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 6:16,032,507...16,108,444
Ensembl chr 6:16,032,585...16,108,443
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Prps1
phosphoribosyl pyrophosphate synthetase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr X:104,132,139...104,154,191
Ensembl chr X:104,132,141...104,154,187
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Pycard
PYD and CARD domain containing
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24508291
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
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Ramp2
receptor activity modifying protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829
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Rfng
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr10:106,047,221...106,050,331
Ensembl chr10:106,047,221...106,050,345
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Rpl28
ribosomal protein L28
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 1:69,052,148...69,054,735
Ensembl chr 1:69,053,203...69,055,032
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Rps28
ribosomal protein S28
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 7:14,607,801...14,609,170
Ensembl chr 7:14,607,801...14,609,170 Ensembl chr16:14,607,801...14,609,170 Ensembl chr16:14,607,801...14,609,170
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Rps8
ribosomal protein S8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 5:130,630,362...130,632,932
Ensembl chr 5:130,629,716...130,633,268
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Ryk
receptor-like tyrosine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 8:103,419,338...103,492,083
Ensembl chr 8:103,419,275...103,491,698
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Scd
stearoyl-CoA desaturase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21661758
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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Scd2
stearoyl-Coenzyme A desaturase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232
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Sepsecs
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr14:58,311,484...58,341,745
Ensembl chr14:58,311,499...58,341,740
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Serpinb6a
serpin family B member 6A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr17:30,871,468...30,989,703
Ensembl chr17:30,871,468...31,014,427
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Sestd1
SEC14 and spectrin domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 3:62,123,590...62,220,759
Ensembl chr 3:62,129,887...62,220,546
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Setbp1
SET binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr18:72,190,542...72,551,272
Ensembl chr18:72,191,035...72,552,556
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Sipa1l1
signal-induced proliferation-associated 1 like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 6:101,839,351...102,118,408
Ensembl chr 6:101,839,404...102,116,950
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Slc6a3
solute carrier family 6 member 3
ISO
associated with kidney transplant;DNA:SNP:CDS (rs6347) (human)
RGD
PMID:26406335
RGD:405650673
NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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Slu7
SLU7 homolog, splicing factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr10:27,908,325...27,923,784
Ensembl chr10:27,908,396...27,923,349
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Sorbs2
sorbin and SH3 domain containing 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr16:46,435,220...46,748,743
Ensembl chr16:46,435,237...46,626,514
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Sparc
secreted protein acidic and cysteine rich
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
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Sptbn1
spectrin, beta, non-erythrocytic 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507
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Sri
sorcin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:33930463
NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077
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Stim2
stromal interaction molecule 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr14:56,878,428...57,004,405
Ensembl chr14:56,878,645...57,004,179
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Sts
steroid sulfatase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24497646
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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Tacr1
tachykinin receptor 1
ISO
RGD
PMID:21467195
RGD:5147668
NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20521320
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tpm4
tropomyosin 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984
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Tsen2
tRNA splicing endonuclease subunit 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 4:148,602,805...148,638,219
Ensembl chr 4:148,602,863...148,638,215
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Vdr
vitamin D receptor
ISO
RGD
PMID:30905785 PMID:30905785
RGD:14402029 , RGD:14402029
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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Vim
vimentin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Vps13d
vacuolar protein sorting 13 homolog D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 5:156,830,509...157,055,895
Ensembl chr 5:156,830,512...157,055,891
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Zdhhc2
zinc finger DHHC-type palmitoyltransferase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr16:51,808,465...51,878,060
Ensembl chr16:51,808,468...51,878,060
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Zwilch
zwilch kinetochore protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19030233
NCBI chr 8:64,638,401...64,670,911
Ensembl chr 8:64,637,672...64,675,916
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Ace
angiotensin I converting enzyme
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:33007385
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Ace2
angiotensin converting enzyme 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33007385
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Adipoq
adiponectin, C1Q and collagen domain containing
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18230824
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Adora2a
adenosine A2a receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26526685
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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Ahr
aryl hydrocarbon receptor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:34848246
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Alpk1
alpha-kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27542954
NCBI chr 2:216,126,939...216,247,180
Ensembl chr 2:216,128,825...216,247,157
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Apc
APC regulator of WNT signaling pathway
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24431404
NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
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Atg5
autophagy related 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26568842
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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Atg7
autophagy related 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26568842
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
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Cd14
CD14 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28411859
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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Cln6
CLN6, transmembrane ER protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23789114
NCBI chr 8:63,303,356...63,318,360
Ensembl chr 8:63,303,029...63,318,360
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Cnr1
cannabinoid receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31570772 PMID:32365865
NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
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Cnr2
cannabinoid receptor 2
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:27611972 PMID:30102254
NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
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Col2a1
collagen type II alpha 1 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26070417 PMID:29908986
NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
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Crh
corticotropin releasing hormone
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8986836
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Csf2
colony stimulating factor 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:38348709
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Epo
erythropoietin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:8260696
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Fst
follistatin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:33034787
NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571
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Gh1
growth hormone 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:7711889
NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
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Gnrh1
gonadotropin releasing hormone 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24431404
NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581 Ensembl chr15:41,972,905...41,973,581
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Hdac3
histone deacetylase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34973135
NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
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Il10
interleukin 10
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:24314293 PMID:27580383
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il4
interleukin 4
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24314293
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Ins1
insulin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29682576 PMID:34352274
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Ins2
insulin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22940631 PMID:29211853
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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Lep
leptin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27417254
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lif
LIF, interleukin 6 family cytokine
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23291613
NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
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Lrrk2
leucine-rich repeat kinase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31174552
NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703
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Ltf
lactotransferrin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24587916
NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
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Mapt
microtubule-associated protein tau
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24556215
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Mt1
metallothionein 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24163136
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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Nppc
natriuretic peptide C
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:37352108
NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251
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Npy
neuropeptide Y
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25825358
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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Otud7b
OTU deubiquitinase 7B
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:36639017
NCBI chr 2:183,661,955...183,722,584
Ensembl chr 2:183,662,163...183,718,674
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Oxt
oxytocin/neurophysin I prepropeptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18562099
NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
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Pomc
proopiomelanocortin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1459535 PMID:11193135
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
G
Sirt4
sirtuin 4
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:35134463
NCBI chr12:41,125,533...41,139,440
Ensembl chr12:41,131,262...41,139,439
G
Snca
synuclein alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32278788
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
G
Sod1
superoxide dismutase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24163136 PMID:29434186
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
G
Tlr3
toll-like receptor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28726298
NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
G
Tlr4
toll-like receptor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31442584
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Tsc22d3
TSC22 domain family, member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22556341
NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all