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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hypertensive Nephropathy
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Accession:DOID:9003234 term browser browse the term
Synonyms:exact_synonym: HNP1
 primary_id: MESH:C563161;   RDO:0012537
 alt_id: MIM:608026


show annotations for term's descendants           Sort by:
Hypertensive Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen treatment IEP RGD PMID:22089474 RGD:8548895 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a treatment IMP RGD PMID:22089474 RGD:8548895 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Cfl1 cofilin 1 IEP protein:increased phosphorylation:kidney (rat) RGD PMID:26450610 RGD:11520804 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Col1a1 collagen type I alpha 1 chain IEP mRNA:increased expression:juxtamedullary cortex (rat) RGD PMID:17977875 RGD:2290351 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Hp haptoglobin treatment IEP RGD PMID:24029866 RGD:11041817 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ameliorates IMP RGD PMID:37643020 RGD:401827835 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp2em2Mcwi matrix metallopeptidase 2; zinc finger nuclease induced mutant 2, Medical College of Wisconsin ameliorates IMP RGD PMID:37643020 RGD:401827835
G Nppb natriuretic peptide B IMP RGD PMID:26063669 RGD:12910116 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nppbem2Mcwi natriuretic peptide B; zinc finger nuclease induced mutant 2, Medical College of Wisconsin IMP RGD PMID:26063669 RGD:12910116
G Postn periostin disease_progression IEP mRNA,protein:increased expression:kidney: RGD PMID:22403621 RGD:10041032 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha IDA Strain: SHRSP RGD PMID:20671072 RGD:5509943 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Rag1 recombination activating 1 ameliorates IMP RGD PMID:23364523 PMID:23364523 RGD:7207429, RGD:7207429 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rag1em1Mcwi recombination activating gene 1; zinc finger nuclease induced mutant 1, Medical College of Wisconsin ameliorates IMP RGD PMID:23364523 RGD:7207429
G Shc1 SHC adaptor protein 1 IMP
IEP		 protein:increased expression:kidney RGD PMID:27270176 PMID:27270176 RGD:12792230, RGD:12792230 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Shc1em5Mcwi SHC adaptor protein 1; ZFN induced mutant 5, Medical College of Wisconsin IMP RGD PMID:27270176 RGD:12792230
G Sirt6 sirtuin 6 ISO protein:decreased expression:kidney RGD PMID:30894089 RGD:155260334 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
Progressive Renal Failure with Hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha ISO RGD PMID:15928032 RGD:7204486 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19137
    Pathological Conditions, Signs and Symptoms 13626
      Pathologic Processes 8326
        Inflammation 2842
          nephritis 496
            Hypertensive Nephropathy 23
              Progressive Renal Failure with Hypertension 1
Path 2
Term Annotations click to browse term
  disease 19137
    disease of anatomical entity 18450
      cardiovascular system disease 5544
        vascular disease 4024
          artery disease 2858
            hypertension 1631
              secondary hypertension 98
                renal hypertension 98
                  Hypertensive Nephropathy 23
                    Progressive Renal Failure with Hypertension 1
paths to the root