Pancreatic Neoplasms - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Pancreatic Neoplasms	go back to main search page
Accession:	DOID:9003100	browse the term
Synonyms:	exact_synonym:	Pancreas Neoplasms; pancreas neoplasm; pancreatic neoplasm
	narrow_synonym:	Borderline Exocrine Pancreatic Neoplasm
	xref:	EFO:0003860; EFO:1000133; NCI:C34035

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Rat (483) Mouse (506) Human (3223) Chinchilla (383) Bonobo (405) Dog (401) Squirrel (391) Pig (395) Green Monkey (398) Naked Mole-rat (380) All
Genes (395)

Adult Pancreatic Cancer

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943

duodenal gastrinoma

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

menin 1

associated with Neuroendocrine Tumors; DNA:loss of heterozygosity: :

NCBI chr 2:7,358,130...7,364,952
Ensembl chr 2:7,358,218...7,364,952

Familial Pancreatic Carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apolipoprotein A4

mRNA:increased expression:pancreas, carcinoma (human)

NCBI chr 9:44,201,587...44,204,072
Ensembl chr 9:44,201,508...44,204,206

G

ATM serine/threonine kinase

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:8755918 PMID:9443866 PMID:9463314 PMID:9887333 PMID:10330348 More...

NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,657...36,759,552

G

BRCA1 associated RING domain 1

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:25085752 PMID:25741868 PMID:26315354 PMID:26467025 PMID:26787654 More...

NCBI chr15:117,049,483...117,135,889
Ensembl chr15:117,047,845...117,175,851

G

chromosome 9 C11orf65 homolog

ClinVar Annotator: match by term: Familial pancreatic carcinoma

NCBI chr 9:36,768,819...36,855,318
Ensembl chr 9:36,776,897...36,849,710

G

cyclin dependent kinase inhibitor 2A

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:7640518 PMID:7647780 PMID:7987387 PMID:8668202 PMID:9823374 More...

NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:1875403 PMID:2547513 PMID:3627975 PMID:7773929 PMID:8439212 More...

NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358

G

SMAD family member 4

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:25741868 PMID:26467025 PMID:26900293 PMID:27611364 PMID:28283864 More...

NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,589,850...100,628,029

G

tumor protein p53

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:1565143 PMID:1565144 PMID:1631137 PMID:1683921 PMID:1978757 More...

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

gastrinoma

term browser

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Object Name

Qualifiers

Evidence

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PubMed Reference(s)

RGD Reference(s)

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G

insulin like growth factor 1 receptor

mRNA and protein: increased expression::poor prognosis for high expression

NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,825...137,691,058

G

menin 1

CTD Direct Evidence: marker/mechanism
DNA:mutations: :

PMID:15944766 PMID:17961653

NCBI chr 2:7,358,130...7,364,952
Ensembl chr 2:7,358,218...7,364,952

G

MET proto-oncogene, receptor tyrosine kinase

severity

associated with Zollinger-Ellison Syndrome; mRNA:increased expression:tumor (human)

NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,048...29,541,512

G

O-6-methylguanine-DNA methyltransferase

DNA:hypomethylation:promoter (human)

NCBI chr14:138,502,005...138,771,543
Ensembl chr14:138,499,309...138,771,540

G

solute carrier family 2 member 2

mRNA:decreased expression:pancreatic islet

PMID:8421107 PMID:12114701

RGD:2324976 RGD:2324977

NCBI chr13:109,592,595...109,614,105
Ensembl chr13:109,587,258...109,638,510

Gastro-Enteropancreatic Neuroendocrine Tumor

term browser

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Object Name

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Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATM serine/threonine kinase

disease_progression

associated with Neoplasm Metastasis;mRNA, protein: decreased expression:gastrointestinal system, multiple (human)

NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,657...36,759,552

G

ATRX chromatin remodeler

severity

NCBI chr X:61,584,028...61,872,341
Ensembl chr X:61,584,848...61,872,287

G

CD53 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 4:109,306,552...109,335,876
Ensembl chr 4:109,306,555...109,335,802

G

CD86 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr13:138,427,573...138,504,307
Ensembl chr13:138,427,533...138,504,310

G

class II major histocompatibility complex transactivator

CTD Direct Evidence: marker/mechanism

NCBI chr 3:32,171,706...32,230,775
Ensembl chr 3:32,172,214...32,230,780

G

C-X-C motif chemokine receptor 4

severity

protein:increased expression:colon (human)

NCBI chr15:15,663,652...15,666,706
Ensembl chr15:15,663,494...15,667,232

G

death domain associated protein

severity

NCBI chr 7:29,676,854...29,681,145
Ensembl chr 7:29,676,856...29,681,110

G

eomesodermin

CTD Direct Evidence: marker/mechanism

NCBI chr13:14,209,590...14,216,184
Ensembl chr13:14,209,736...14,215,797

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:63,367,684...63,397,977
Ensembl chr10:63,367,663...63,388,859

G

growth factor independent 1 transcriptional repressor

CTD Direct Evidence: marker/mechanism

NCBI chr 4:124,619,887...124,629,638
Ensembl chr 4:124,621,261...124,629,638

G

IKAROS family zinc finger 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:136,372,202...136,464,942
Ensembl chr 9:136,372,725...136,464,940

G

IKAROS family zinc finger 3

CTD Direct Evidence: marker/mechanism

NCBI chr12:22,466,386...22,562,320
Ensembl chr12:22,466,414...22,562,312

G

interleukin 10

CTD Direct Evidence: marker/mechanism

NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378

G

interleukin 2 receptor subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr 5:10,610,094...10,650,315
Ensembl chr 5:10,628,962...10,650,314

G

notch receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 4:100,951,522...101,152,348
Ensembl chr 4:100,981,636...101,150,195

G

POU class 2 homeobox 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:49,791,937...49,829,771
Ensembl chr 6:49,727,012...49,825,816

G

protein tyrosine phosphatase receptor type C

CTD Direct Evidence: marker/mechanism

NCBI chr10:21,482,984...21,601,627
Ensembl chr10:21,560,073...21,601,308

G

RUNX family transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 6:82,531,203...82,595,044
Ensembl chr 6:82,531,559...82,595,026

G

serpin family A member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:115,604,282...115,616,915
Ensembl chr 7:115,583,043...115,614,645

Glucagonoma

term browser

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PubMed Reference(s)

RGD Reference(s)

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G

betacellulin

protein:increased expression:pancreas

NCBI chr 8:70,645,721...70,697,538
Ensembl chr 8:70,649,317...70,697,420

G

menin 1

CTD Direct Evidence: marker/mechanism
DNA:deletion:exon

PMID:17961653 PMID:20138042

NCBI chr 2:7,358,130...7,364,952
Ensembl chr 2:7,358,218...7,364,952

G

solute carrier family 2 member 2

mRNA:decreased expression:pancreatic islet

PMID:8421107 PMID:12114701

RGD:2324976 RGD:2324977

NCBI chr13:109,592,595...109,614,105
Ensembl chr13:109,587,258...109,638,510

insulinoma

term browser

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PubMed Reference(s)

RGD Reference(s)

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G

adrenomedullin

protein:increased expression:pancreas, plasma

NCBI chr 2:49,229,223...49,231,521
Ensembl chr 2:49,229,223...49,231,866

G

betacellulin

protein:increased expression:pancreas

NCBI chr 8:70,645,721...70,697,538
Ensembl chr 8:70,649,317...70,697,420

G

CD40 molecule

NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528

G

cut like homeobox 1

disease_progression
exacerbates

mRNA:increased expression:pancreas (mouse)
protein:increased expression:pancreas (human)

NCBI chr 3:9,317,145...9,669,999
Ensembl chr 3:9,317,140...9,669,998

G

C-X-C motif chemokine ligand 12

protein:increased expression:pancreas

NCBI chr14:91,516,383...91,543,857
Ensembl chr14:91,516,431...91,552,752

G

insulin

protein:altered expression:blood
protein:altered localization:pancreas

PMID:2565624 PMID:8175958

RGD:2317266 RGD:2317268

NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841

G

menin 1

disease_progression

DNA:deletion:exon
DNA:deletions:exons
CTD Direct Evidence: marker/mechanism

PMID:12941803 PMID:17961653 PMID:19208834 PMID:20138042

RGD:2317288 RGD:2317292 RGD:2317310

NCBI chr 2:7,358,130...7,364,952
Ensembl chr 2:7,358,218...7,364,952

G

neural cell adhesion molecule 1

protein:increased expression:pancreas

NCBI chr 9:40,628,602...40,960,605
Ensembl chr 9:40,628,631...40,960,591

G

ribosomal protein S15

NCBI chr 2:77,043,329...77,044,749
Ensembl chr 2:77,043,329...77,046,747

G

solute carrier family 2 member 2

protein:increased expression:pancreatic B cell
mRNA:decreased expression:pancreatic islet

PMID:8421107 PMID:12114701

RGD:2324976 RGD:2324977

NCBI chr13:109,592,595...109,614,105
Ensembl chr13:109,587,258...109,638,510

G

transforming growth factor alpha

protein:increased expression:pancreas

NCBI chr 3:71,948,232...72,054,257
Ensembl chr 3:71,948,137...72,050,474

G

transforming growth factor beta 1

mRNA, protein:decreased expression:pancreatic islet

NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046

Islet Cell Adenomatosis

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Source

PubMed Reference(s)

RGD Reference(s)

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G

MAF bZIP transcription factor A

ClinVar Annotator: match by term: Islet cell adenomatosis

PMID:25741868 PMID:29339498 PMID:35406570

NCBI chr 4:1,090,018...1,093,600
Ensembl chr 4:1,090,874...1,093,600

islet cell tumor

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATRX chromatin remodeler

disease_progression

protein:decreased expression:pancreas:

NCBI chr X:61,584,028...61,872,341
Ensembl chr X:61,584,848...61,872,287

G

cyclin dependent kinase 4

protein:increased expression:pancreas, islet of Langerhans (human)

NCBI chr 5:23,039,206...23,041,959
Ensembl chr 5:23,038,891...23,042,061

G

death domain associated protein

disease_progression

NCBI chr 7:29,676,854...29,681,145
Ensembl chr 7:29,676,856...29,681,110

G

proprotein convertase subtilisin/kexin type 1

protein:increased expression:insulinoma (rat)

NCBI chr 2:103,004,794...103,050,707
Ensembl chr 2:103,004,794...103,050,839

Islet Cell Tumor Syndrome

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

farnesyltransferase, CAAX box, beta

ClinVar Annotator: match by term: Chromaffinoma

NCBI chr 7:89,052,451...89,131,075
Ensembl chr 7:89,052,507...89,131,072

G

MYC associated factor X

ClinVar Annotator: match by term: Chromaffinoma

PMID:21685915 PMID:22452945 PMID:23666964 PMID:25741868 PMID:26070438 More...

NCBI chr 7:89,142,966...89,168,265
Ensembl chr 7:89,142,969...89,168,201

G

myelin protein zero

ClinVar Annotator: match by term: Chromaffinoma

PMID:12807974 PMID:17468193 PMID:19454582 PMID:23342407 PMID:24033266 More...

NCBI chr 4:89,174,107...89,179,556
Ensembl chr 4:89,169,311...89,179,925

G

neurofibromin 1

ClinVar Annotator: match by term: Chromaffinoma

PMID:1568247 PMID:8264648 PMID:8499944 PMID:8499945 PMID:8669813 More...

NCBI chr12:43,487,098...43,754,205
Ensembl chr12:43,489,813...43,753,969

G

ret proto-oncogene

ClinVar Annotator: match by term: Chromaffinoma

PMID:2008030 PMID:2660074 PMID:2904651 PMID:3078962 PMID:7536460 More...

NCBI chr14:61,305,818...61,361,416
Ensembl chr14:61,305,841...61,361,412

G

succinate dehydrogenase complex assembly factor 2

ClinVar Annotator: match by term: Chromaffinoma

NCBI chr 2:10,074,965...10,088,185
Ensembl chr 2:10,072,920...10,088,117

G

succinate dehydrogenase complex iron sulfur subunit B

ClinVar Annotator: match by term: Chromaffinoma

PMID:490809 PMID:2308387 PMID:9509062 PMID:9536098 PMID:11404820 More...

NCBI chr 6:75,648,362...75,678,111
Ensembl chr 6:75,648,215...75,678,378

G

succinate dehydrogenase complex subunit C

ClinVar Annotator: match by term: Chromaffinoma

PMID:12807974 PMID:17468193 PMID:19454582 PMID:22517554 PMID:22703879 More...

NCBI chr 4:89,135,410...89,169,164
Ensembl chr 4:89,130,379...89,169,118

G

succinate dehydrogenase complex subunit D

ClinVar Annotator: match by term: Chromaffinoma

PMID:1945482 PMID:8981955 PMID:9536098 PMID:9683583 PMID:10323245 More...

NCBI chr 9:39,790,654...39,803,602
Ensembl chr 9:39,790,595...39,803,950

G

transmembrane protein 127

ClinVar Annotator: match by term: Chromaffinoma

PMID:9536098 PMID:16266984 PMID:17576681 PMID:20154675 PMID:20923864 More...

NCBI chr 3:46,966,858...47,017,659
Ensembl chr 3:46,966,892...46,978,810

G

von Hippel-Lindau tumor suppressor

ClinVar Annotator: match by term: Chromaffinoma

PMID:7563486 PMID:7987306 PMID:8707293 PMID:8772572 PMID:8956040 More...

NCBI chr13:66,334,535...66,342,401
Ensembl chr13:66,334,591...66,342,654

Melanoma-Pancreatic Cancer Syndrome

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin dependent kinase inhibitor 2A

ClinVar Annotator: match by term: Melanoma-pancreatic cancer syndrome

PMID:2319082 PMID:2813514 PMID:5001868 PMID:7566978 PMID:7632931 More...

NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854

non-functioning pancreatic endocrine tumor

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AT-rich interaction domain 1A

exacerbates

protein:decreased expression:endocrine pancreas (human)

NCBI chr 6:84,049,729...84,124,302
Ensembl chr 6:84,049,087...84,123,349

G

cyclin dependent kinase 4

associated with multiple endocrine neoplasia type 1;mRNA:increased expression:islet of Langerhans (human)

NCBI chr 5:23,039,206...23,041,959
Ensembl chr 5:23,038,891...23,042,061

G

cyclin dependent kinase 6

associated with multiple endocrine neoplasia type 1;mRNA:increased expression:islet of Langerhans (human)

NCBI chr 9:72,510,858...72,765,631
Ensembl chr 9:72,518,101...72,764,129

pancreatic acinar cell adenocarcinoma

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

B-Raf proto-oncogene, serine/threonine kinase

DNA:missense mutation, gene fusions:multiple (human)

NCBI chr18:8,957,963...9,132,558
Ensembl chr18:8,957,991...9,132,553

G

SRC proto-oncogene, non-receptor tyrosine kinase

disease_progression

NCBI chr17:40,470,970...40,524,862
Ensembl chr17:40,471,009...40,524,860

pancreatic adenocarcinoma

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adhesion G protein-coupled receptor B1

mRNA:decreased expression:pancreas

NCBI chr 4:1,582,321...1,658,639
Ensembl chr 4:1,582,330...1,658,942

G

AKT serine/threonine kinase 3

severity

mRNA:increased expression:pancreas (human)

NCBI chr10:16,441,465...16,741,745
Ensembl chr10:16,441,447...16,741,337

G

baculoviral IAP repeat containing 3

disease_progression

mRNA:increased expression:pancreas (human)

NCBI chr 9:33,003,570...33,020,252
Ensembl chr 9:33,002,734...33,020,242

G

baculoviral IAP repeat containing 5

exacerbates

mRNA:increased expression:pancreas (human)

NCBI chr12:3,747,276...3,755,214
Ensembl chr12:3,747,279...3,755,215

G

baculoviral IAP repeat containing 7

exacerbates

mRNA:increased expression:pancreas (human)

NCBI chr17:62,351,663...62,356,220

G

carbonyl reductase 4

ClinVar Annotator: match by term: Pancreatic adenocarcinoma

PMID:9536098 PMID:17576681 PMID:25741868 PMID:28166811 PMID:28492532

NCBI chr14:20,621,960...20,642,351
Ensembl chr14:20,621,981...20,682,240

G

cyclin D1

severity

protein:increased expression:pancreas (human)

NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296

G

cyclin dependent kinase 4

treatment

human cells in a mouse model

NCBI chr 5:23,039,206...23,041,959
Ensembl chr 5:23,038,891...23,042,061

G

cyclin dependent kinase 6

treatment

human cells in a mouse model

NCBI chr 9:72,510,858...72,765,631
Ensembl chr 9:72,518,101...72,764,129

G

cyclin dependent kinase inhibitor 2A

DNA:missense mutations:cds:p.V126D, p.A148T (human)

NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854

G

C-X-C motif chemokine receptor 4

NCBI chr15:15,663,652...15,666,706
Ensembl chr15:15,663,494...15,667,232

G

E2F transcription factor 1

treatment

Human cells in a mouse model

NCBI chr17:37,178,587...37,190,118
Ensembl chr17:37,178,599...37,189,883

G

histidine rich glycoprotein

disease_progression

NCBI chr13:124,505,305...124,516,387
Ensembl chr13:124,505,312...124,516,705

G

Janus kinase 1

treatment

human cell line in a mouse model

NCBI chr 6:147,320,288...147,567,188
Ensembl chr 6:147,429,056...147,567,182

G

baculoviral IAP repeat-containing protein 2

exacerbates

mRNA:increased expression:pancreas (human)

NCBI chr 9:33,041,592...33,062,865
Ensembl chr 9:33,041,663...33,062,854

G

mitogen-activated protein kinase kinase 1

treatment
severity

human tissue in a mouse model
protein:increased expression:pancreas (human)

PMID:19513748 PMID:28849200

RGD:13838804 RGD:13838840

NCBI chr 1:164,381,892...164,469,313
Ensembl chr 1:164,381,845...164,471,226

G

mitogen-activated protein kinase 1

severity

mRNA:increased expression:pancreas (human)

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 10

severity

DNA:SNP:intron: (rs2589506) (human)

NCBI chr 8:132,445,818...132,751,575
Ensembl chr 8:132,298,299...132,776,820

G

mitogen-activated protein kinase 8

exacerbates

protein:increased phosphorylation:pancreas (human)

NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874

G

mitogen-activated protein kinase 9

NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100

G

nuclear factor kappa B subunit 1

severity

mRNA:increased expression:pancreas (human)

NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691

G

palladin, cytoskeletal associated protein

ClinVar Annotator: match by term: Pancreatic adenocarcinoma

PMID:9536098 PMID:10454945 PMID:11474289 PMID:17194196 PMID:17415588 More...

NCBI chr14:20,678,456...21,020,125
Ensembl chr14:20,678,452...21,020,125

G

plasminogen activator, tissue type

mRNA:increased expression:pancreas (human)

NCBI chr17:11,195,599...11,223,821
Ensembl chr17:11,195,602...11,224,032

G

Rac family small GTPase 1

treatment

human cells in a mouse model

NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543

G

Raf-1 proto-oncogene, serine/threonine kinase

treatment

human cells in a mouse model

NCBI chr13:68,581,128...68,657,911
Ensembl chr13:68,580,812...68,657,829

G

RAS like proto-oncogene B

treatment

human cells in a mouse model

NCBI chr15:31,064,341...31,118,437
Ensembl chr15:31,064,355...31,122,621

G

ralA binding protein 1

treatment

human cells in a mouse model

NCBI chr 6:98,550,925...98,598,945
Ensembl chr 6:98,550,933...98,598,206

G

SMAD family member 7

severity

human cell and construct in a mouse model

NCBI chr 1:98,512,800...98,543,924
Ensembl chr 1:98,514,267...98,542,382

G

signal transducer and activator of transcription 1

ameliorates

protein:increased expression:pancreas (human)

NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260

G

vascular endothelial growth factor C

exacerbates

protein:increased expression:pancreas (human)

NCBI chr15:39,037,764...39,136,234
Ensembl chr15:39,039,311...39,132,936

pancreatic adenosquamous carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

transforming growth factor beta 2

ameliorates

human cells in a mouse model

NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,539...8,390,341

pancreatic cancer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1,4-N-acetylglucosaminyltransferase

mRNA:increased expression:blood, mononuclear cell

NCBI chr13:78,921,212...78,932,575
Ensembl chr13:78,923,681...78,932,504

G

ATP binding cassette subfamily C member 2

mRNA, protein:increased expression:pancreas

NCBI chr14:110,955,698...111,038,898
Ensembl chr14:110,955,582...111,038,898

G

ATP binding cassette subfamily C member 3

severity

mRNA:increased expression:pancreas

NCBI chr12:26,920,764...26,978,389
Ensembl chr12:26,920,821...26,979,602

G

ATP binding cassette subfamily C member 5

mRNA:increased expression:pancreas

NCBI chr13:121,868,614...121,957,901
Ensembl chr13:121,869,600...121,926,071

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

CTD Direct Evidence: marker/mechanism

PMID:19648918 PMID:20103627 PMID:26098869

NCBI chr 1:272,912,239...272,935,316

G

angiotensin I converting enzyme

NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703

G

activin A receptor type 1

NCBI chr15:64,749,478...64,891,653
Ensembl chr15:64,750,796...64,891,544

G

activin A receptor type 1B

NCBI chr 5:17,314,322...17,350,726
Ensembl chr 5:17,314,276...17,350,722

G

activin A receptor type 2A

NCBI chr15:4,177,333...4,259,056
Ensembl chr15:4,173,805...4,259,706

G

ADAM metallopeptidase domain 15

mRNA:increased expression:pancreas, epithelial cell

NCBI chr 4:94,736,639...94,748,093
Ensembl chr 4:94,736,646...94,748,098

G

ADAM metallopeptidase domain 9

mRNA:increased expression:pancreas, epithelial cell

NCBI chr15:47,523,768...47,601,722
Ensembl chr15:47,523,771...47,601,710

G

adhesion G protein-coupled receptor E5

protein:increased expression:pancreas

NCBI chr 2:64,844,793...64,862,231
Ensembl chr 2:64,844,798...64,890,939

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

DNA:polymorphism: :p.R272Q (human)

NCBI chr 8:121,089,355...121,105,010
Ensembl chr 8:121,020,910...121,108,190

G

adrenomedullin

disease_progression

PMID:16841081 PMID:17363587

RGD:2325317 RGD:2325318

NCBI chr 2:49,229,223...49,231,521
Ensembl chr 2:49,229,223...49,231,866

G

advanced glycosylation end-product specific receptor

protein:decreased expression:serum

NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,120...24,221,162

G

angiotensin II receptor type 2

mRNA:increased expression:pancreas

NCBI chr X:95,267,709...95,272,237
Ensembl chr X:95,269,300...95,270,388

G

aryl hydrocarbon receptor

mRNA:increased expression:pancreas
CTD Direct Evidence: marker/mechanism|therapeutic

PMID:12203118 PMID:25826687

NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943

G

AKT serine/threonine kinase 1

treatment
severity

human cells in a mouse model
protein:increased phosphorylation:pancreas (human)

PMID:11595724 PMID:20697673

RGD:13450953 RGD:13452388

G

albumin

disease_progression

PMID:18154768 PMID:20508721

RGD:2325675 RGD:2325678

NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696

G

aldehyde dehydrogenase 1 family member A1

protein:decreased expression:pancreas

NCBI chr 1:226,163,347...226,217,342
Ensembl chr 1:226,161,299...226,217,308

G

aldehyde dehydrogenase 2 family member

susceptibility

DNA:polymorphism (human)
DNA:polymorphism: :p.E504K (human)

PMID:15714130 PMID:19068087

RGD:2325313 RGD:2325694

NCBI chr14:39,902,317...39,933,113
Ensembl chr14:39,896,565...39,933,124

G

arachidonate 12-lipoxygenase, 12R type

CTD Direct Evidence: marker/mechanism

NCBI chr12:53,292,530...53,302,850
Ensembl chr12:53,292,526...53,302,993

G

arachidonate 5-lipoxygenase

protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism

PMID:12163367 PMID:12481414 PMID:30258081

RGD:2317523 RGD:2317524

NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,019...90,907,090

G

angiogenin

disease_progression

mRNA, protein:increased expression:pancreas, serum

NCBI chr 7:78,249,479...78,262,846
Ensembl chr 7:78,249,487...78,250,138

G

annexin A1

protein:increased expression:pancreas

PMID:17974280 PMID:19173988

RGD:2325722 RGD:2325723

NCBI chr 1:226,414,200...226,431,963
Ensembl chr 1:226,414,306...226,432,279

G

annexin A10

CTD Direct Evidence: marker/mechanism

NCBI chr14:21,249,020...21,315,260
Ensembl chr14:21,248,531...21,315,190

G

apoptotic peptidase activating factor 1

mRNA:increased expression:pancreas

NCBI chr 5:85,166,616...85,258,751
Ensembl chr 5:85,166,628...85,258,364

G

APC regulator of WNT signaling pathway

ClinVar Annotator: match by term: Cancer of the pancreas

PMID:1316610 PMID:8381579 PMID:9101302 PMID:9824584 PMID:11852337 More...

NCBI chr 2:116,913,354...116,985,303
Ensembl chr 2:116,812,582...117,034,887

G

apolipoprotein A1

protein:decreased expression:serum
protein:increased expression:pancreas

PMID:17312459 PMID:17332923

RGD:2325757 RGD:2325758

NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713

G

apolipoprotein E

protein:increased expression:pancreas (human)

NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330

G

actin related protein 2/3 complex subunit 1A

DNA:amplification (human)

NCBI chr 3:6,296,257...6,324,526
Ensembl chr 3:6,296,278...6,324,524

G

artemin

disease_progression

mRNA:increased expression:pancreas

PMID:19304517 PMID:20395845

RGD:2325815 RGD:2325817

NCBI chr 6:167,356,363...167,361,370
Ensembl chr 6:167,357,662...167,361,221

G

ATM serine/threonine kinase

susceptibility

DNA:SNP:exon:rs1801516(human)
ClinVar Annotator: match by term: Pancreatic cancer

PMID:8698354 PMID:8845835 PMID:9497252 PMID:9536098 PMID:9792409 More...

NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,657...36,759,552

G

ATR serine/threonine kinase

DNA:SNP: :340C>T (human)

NCBI chr13:83,175,515...83,289,986
Ensembl chr13:83,174,824...83,289,989

G

ATRX chromatin remodeler

CTD Direct Evidence: marker/mechanism

NCBI chr X:61,584,028...61,872,341
Ensembl chr X:61,584,848...61,872,287

G

AXL receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 6:49,245,802...49,277,917
Ensembl chr 6:49,245,673...49,277,914

G

beta-1,3-galactosyltransferase 5

mRNA:increased expression:pancreas

NCBI chr13:203,208,353...203,250,085

G

BCL2 associated agonist of cell death

treatment

human cells in a mouse model

NCBI chr 2:7,831,192...7,842,864
Ensembl chr 2:7,830,920...7,842,863

G

BAG cochaperone 3

mRNA:increased expression:pancreas

NCBI chr14:129,510,240...129,533,998
Ensembl chr14:129,466,905...129,533,993

G

BAG cochaperone 4

mRNA:increased expression:pancreas

NCBI chr15:48,299,456...48,348,810
Ensembl chr15:48,299,666...48,348,527

G

BRCA1 associated deubiquitinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:34,544,570...34,553,538
Ensembl chr13:34,544,581...34,553,483

G

BCAR1 scaffold protein, Cas family member

CTD Direct Evidence: marker/mechanism

NCBI chr 6:12,369,332...12,404,822
Ensembl chr 6:12,367,758...12,404,818

G

BCL2 like 1

severity

CTD Direct Evidence: marker/mechanism
human gene in a mouse model

PMID:16904634 PMID:17941720

NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694

G

BH3 interacting domain death agonist

NCBI chr 5:69,849,007...69,874,647
Ensembl chr 5:69,849,002...69,875,853

G

B-Raf proto-oncogene, serine/threonine kinase

disease_progression

human gene in a mouse model

PMID:18490924 PMID:22628411 PMID:22871572

RGD:13451537 RGD:13461863 RGD:13462040

NCBI chr18:8,957,963...9,132,558
Ensembl chr18:8,957,991...9,132,553

G

BRCA1 DNA repair associated

ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4

PMID:1157798 PMID:2173504 PMID:2316185 PMID:2504116 PMID:2618727 More...

NCBI chr12:19,788,087...19,854,515
Ensembl chr12:19,786,020...19,854,668

G

BRCA2 DNA repair associated

susceptibility

ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2
DNA:mutations: :
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2

ClinVar
RGD
OMIM

PMID:186727 PMID:251866 PMID:278235 PMID:1772447 PMID:2200631 More...

NCBI chr11:8,805,950...8,858,128
Ensembl chr11:8,805,913...8,857,793

G

basigin

CTD Direct Evidence: marker/mechanism

NCBI chr 2:77,735,586...77,743,451

G

BUB1 mitotic checkpoint serine/threonine kinase B

protein:altered localization:pancreas

NCBI chr 1:131,093,026...131,143,840
Ensembl chr 1:131,092,958...131,143,794

G

calcium binding protein 39

disease_progression

NCBI chr15:131,492,575...131,584,963
Ensembl chr15:131,492,578...131,584,962

G

calcyclin binding protein

disease_progression

mRNA, protein:increased expression:pancreas

NCBI chr 9:117,062,303...117,077,442
Ensembl chr 9:117,064,187...117,123,126

G

cyclase associated actin cytoskeleton regulatory protein 1

disease_progression

mRNA, protein:increased expression:pancreas

NCBI chr 6:95,811,485...95,840,576
Ensembl chr 6:95,812,179...95,840,570

G

calpain 10

susceptibility

DNA:SNP:intron:rs3792267 (human)

NCBI chr15:139,557,643...139,568,764
Ensembl chr15:139,557,469...139,568,767

G

caspase 8

susceptibility

DNA:deletion, insertion:promoter (human)
DNA:SNP: :rs1045485 (human)

PMID:18483392 PMID:19843670

RGD:2315744 RGD:2317230

NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468

G

caspase 9

treatment
susceptibility

DNA:snp:promoter:g.-1263A>G (human)

PMID:19209030 PMID:20357690

RGD:13451540 RGD:13462046

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

catalase

disease_progression

protein:decreased expression:pancreas

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

carbonyl reductase 4

ClinVar Annotator: match by term: PALLD-related condition | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1

PMID:25741868 PMID:28492532

NCBI chr14:20,621,960...20,642,351
Ensembl chr14:20,621,981...20,682,240

G

cholecystokinin A receptor

mRNA:increased expression:pancreas

PMID:8222074 PMID:10457335

RGD:4110817 RGD:4110822

NCBI chr 8:20,187,324...20,200,273
Ensembl chr 8:20,188,830...20,199,344

G

cholecystokinin B receptor

susceptibility
disease_progression

mRNA:increased expression:pancreas

PMID:1458479 PMID:8222074 PMID:8302799 PMID:15688412

RGD:4110821 RGD:4110822 RGD:4110823 RGD:4110829

NCBI chr 9:3,409,222...3,419,513

G

C-C motif chemokine ligand 20

CTD Direct Evidence: marker/mechanism

PMID:10225458 PMID:30603057

NCBI chr15:129,172,743...129,176,069

G

C-C motif chemokine ligand 5

NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118

G

cyclin D1

disease_progression
treatment

human cells in a mouse model
mRNA, protein:increased expression:pancreas (mouse)

PMID:11159909 PMID:17541034 PMID:22722256

RGD:13451541 RGD:13452385 RGD:13462059

NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296

G

cyclin G1

treatment

human cells in mouse model

NCBI chr16:60,349,255...60,356,737
Ensembl chr16:60,349,258...60,356,738

G

C-C motif chemokine receptor 4

protein:increased expression:pancreas

NCBI chr13:18,860,596...18,865,987
Ensembl chr13:18,860,730...18,865,983

G

C-C motif chemokine receptor 5

NCBI chr13:29,382,383...29,387,902
Ensembl chr13:29,383,303...29,387,895

G

CD44 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 2:25,788,699...25,884,209
Ensembl chr 2:25,788,703...25,884,153

G

cell division cycle 42

severity

mRNA, protein:increased expression:pancreas (human)

NCBI chr 6:80,035,034...80,089,243
Ensembl chr 6:80,035,123...80,089,233

G

cadherin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:18,075,487...18,155,986
Ensembl chr 6:18,075,480...18,155,986

G

cyclin dependent kinase 4

disease_progression
susceptibility

protein:increased expression:pancreas (mouse)
protein:increased expression:islet of Langerhans (human)
protein:increased expression:islet of Langerhans, nucleus (rat)

PMID:11159909 PMID:22477723 PMID:22761470 PMID:24531709

RGD:13452384 RGD:13452385 RGD:13452386 RGD:13452387

NCBI chr 5:23,039,206...23,041,959
Ensembl chr 5:23,038,891...23,042,061

G

cyclin dependent kinase inhibitor 2A

CTD Direct Evidence: marker/mechanism
DNA:mutations:exon

PMID:10627132 PMID:18772397 PMID:26098869

NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854

G

CASP8 and FADD like apoptosis regulator

CTD Direct Evidence: marker/mechanism

NCBI chr15:104,780,744...104,835,631
Ensembl chr15:104,781,616...104,835,630

G

CF transmembrane conductance regulator

onset
no_association

PMID:16227367 PMID:17072959

RGD:2317156 RGD:2317157

NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950

G

checkpoint kinase 1

disease_progression

DNA:SNP: :35G>A (human)

NCBI chr 9:52,759,224...52,790,878
Ensembl chr 9:52,753,528...52,790,700

G

claudin 4

PMID:19555390 PMID:19793693

RGD:2317580 RGD:2317583

NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925

G

CLPTM1 regulator of GABA type A receptor forward trafficking

CTD Direct Evidence: marker/mechanism

NCBI chr 6:51,411,774...51,441,644
Ensembl chr 6:51,413,602...51,441,816

G

cannabinoid receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:56,466,022...56,493,275
Ensembl chr 1:56,467,835...56,492,602

G

cannabinoid receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:81,659,162...81,692,550
Ensembl chr 6:81,659,169...81,692,550

G

catenin beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311

G

C-X-C motif chemokine ligand 8

CTD Direct Evidence: marker/mechanism

NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861

G

cytochrome c, somatic

NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866

G

cytochrome P450 family 17 subfamily A member 1

susceptibility

DNA:transition:5' utr:-34T>C rs743572 (human)

NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041

G

death domain associated protein

CTD Direct Evidence: marker/mechanism

NCBI chr 7:29,676,854...29,681,145
Ensembl chr 7:29,676,856...29,681,110

G

discoidin domain receptor tyrosine kinase 1

treatment

NCBI chr 7:23,371,358...23,391,585
Ensembl chr 7:23,373,777...23,391,585

G

dihydropyrimidine dehydrogenase

disease_progression

CTD Direct Evidence: marker/mechanism
protein:increased expression:pancreas

PMID:17443278 PMID:18309485 PMID:19020767 PMID:20072795

RGD:2317629 RGD:2317630

NCBI chr 4:119,931,471...120,712,461
Ensembl chr 4:119,931,414...120,712,459

G

dual specificity tyrosine phosphorylation regulated kinase 1A

CTD Direct Evidence: marker/mechanism

NCBI chr13:201,008,506...201,159,946
Ensembl chr13:201,009,480...201,159,948

G

E2F transcription factor 1

treatment

NCBI chr17:37,178,587...37,190,118
Ensembl chr17:37,178,599...37,189,883

G

EGF containing fibulin extracellular matrix protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:85,407,677...85,473,251
Ensembl chr 3:85,407,677...85,473,252

G

epidermal growth factor

disease_progression

protein:increased expression:pancreas

NCBI chr 8:112,235,607...112,330,062
Ensembl chr 8:112,234,386...112,330,046

G

epidermal growth factor receptor

CTD Direct Evidence: marker/mechanism

PMID:17452677 PMID:27720938

NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589

G

eukaryotic translation initiation factor 4A3

protein:increased expression:serum (human)

NCBI chr12:2,285,679...2,311,750
Ensembl chr12:2,285,579...2,313,874

G

epithelial cell adhesion molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 3:93,169,800...93,185,221
Ensembl chr 3:93,168,852...93,185,653

G

EPH receptor A3

NCBI chr13:166,592,492...166,942,791
Ensembl chr13:166,592,493...166,942,767

G

ERCC excision repair 1, endonuclease non-catalytic subunit

susceptibility

DNA:snp:3' utr:c.*197G>T (rs3212986) (human)

NCBI chr 6:51,783,537...51,808,898
Ensembl chr 6:51,783,478...51,798,984

G

ERCC excision repair 2, TFIIH core complex helicase subunit

treatment

pancreatic adenocarcinoma;DNA:SNPs: :rs1799793,rs1052555(human)
DNA,protein:SNPs:exons:rs1799793,rs1052559

PMID:16458430 PMID:18544627 PMID:21404106

RGD:11252206 RGD:2317223 RGD:2317228

NCBI chr 6:51,734,318...51,757,508
Ensembl chr 6:51,734,320...51,757,553

G

ERCC excision repair 4, endonuclease catalytic subunit

pancreatic adenocarcinoma;DNA:SNP: :rs1800067(human)

NCBI chr 3:29,266,234...29,306,109
Ensembl chr 3:29,269,989...29,306,151

G

ETAA1 activator of ATR kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:74,721,313...74,736,784
Ensembl chr 3:74,724,291...74,736,764

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

protein:increased expression:pancreas

NCBI chr 9:109,384,976...109,450,943
Ensembl chr 9:109,385,015...109,450,941

G

FA complementation group A

DNA,Protein:polymorphisms:exons:c.377C>G, c.661A>G (human)

NCBI chr 6:253,207...300,159
Ensembl chr 6:253,207...300,152

G

FA complementation group C

DNA:nonsense mutation (human)

PMID:15695377 PMID:16243825

RGD:2317238 RGD:2317239

NCBI chr10:26,796,546...27,055,271
Ensembl chr10:26,796,572...27,061,801

G

FA complementation group G

NCBI chr 1:235,871,073...235,879,604
Ensembl chr 1:235,871,075...235,877,974

G

Fas ligand

severity
resistance

DNA:polymorphism:promoter:-844>>T (human)

PMID:11115536 PMID:12370548 PMID:18483392

RGD:2315744 RGD:2317744 RGD:2317745

NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464

G

fibroblast growth factor 13

CTD Direct Evidence: marker/mechanism

NCBI chr X:113,460,191...113,955,691
Ensembl chr X:113,460,191...113,932,715

G

fibroblast growth factor 2

severity

mRNA:increased expression:pancreas
protein:increased expression:bile

PMID:9293890 PMID:11478488 PMID:11562741 PMID:12670449

RGD:2317759 RGD:2317760 RGD:2317762 RGD:2317765

NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916

G

forkhead box P1

CTD Direct Evidence: marker/mechanism

NCBI chr13:52,346,844...52,974,358
Ensembl chr13:52,348,234...52,876,892

G

fascin actin-bundling protein 1

severity

protein:increased expression:pancreas

NCBI chr 3:4,134,173...4,143,275
Ensembl chr 3:4,134,177...4,143,286

G

FXYD domain containing ion transport regulator 3

CTD Direct Evidence: marker/mechanism

NCBI chr 6:44,647,771...44,654,377
Ensembl chr 6:44,647,466...44,654,374

G

growth arrest and DNA damage inducible alpha

CTD Direct Evidence: therapeutic

NCBI chr 6:144,940,702...144,944,089
Ensembl chr 6:144,940,697...144,944,089

G

glial cell derived neurotrophic factor

severity

NCBI chr16:22,936,602...22,965,929
Ensembl chr16:22,936,604...22,966,536

G

GNAS complex locus

NCBI chr17:58,985,580...59,053,022
Ensembl chr17:58,998,981...59,053,021

G

golgi membrane protein 1

NCBI chr10:29,117,578...29,219,024
Ensembl chr10:29,118,314...29,219,018

G

hepatocyte growth factor

protein:increased expression:serum

NCBI chr 9:98,437,771...98,513,573
Ensembl chr 9:98,438,143...98,513,564

G

hypoxia inducible factor 1 subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845

G

heparan sulfate-glucosamine 3-sulfotransferase 2

DNA:hypermethylation:promoter (human)

NCBI chr 3:23,255,936...23,366,570
Ensembl chr 3:23,255,961...23,366,351

G

heat shock protein family B (small) member 1

disease_progression

NCBI chr 3:10,038,074...10,039,441
Ensembl chr 3:10,037,949...10,039,704

G

intercellular adhesion molecule 1

mRNA, protein:increased expression:pancreas

NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205

G

interferon, alpha 1

CTD Direct Evidence: therapeutic

PMID:17198089 PMID:17961653

NCBI chr 1:201,515,835...201,516,477
Ensembl chr 1:201,515,809...201,516,488

G

interferon gamma

protein:increased expression:plasma

NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670

G

insulin like growth factor 1

susceptibility

DNA:polymorphism (human)

NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033

G

insulin like growth factor 1 receptor

PMID:14559833 PMID:19732452 PMID:19885860

RGD:2317640 RGD:2317642 RGD:2317651

NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,825...137,691,058

G

interleukin 10

disease_progression
susceptibility

protein:increased expression:serum
DNA:polymorphism: :-1082G>A (human)

PMID:17235586 PMID:19250218 PMID:30304975 PMID:30610790

RGD:14975253 RGD:14975257 RGD:2317653 RGD:2317655

NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378

G

interleukin 13

disease_progression

protein:increased expression:pancreas

PMID:12808442 PMID:18758789

RGD:2317669 RGD:2317670

NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093

G

interleukin 13 receptor subunit alpha 2

treatment

NCBI chr X:94,402,665...94,455,609
Ensembl chr X:94,402,676...94,439,060

G

interleukin 1 alpha

NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,121

G

interleukin 2

treatment

NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609

G

interleukin 24

CTD Direct Evidence: therapeutic

NCBI chr 9:67,525,246...67,532,407
Ensembl chr 9:67,525,557...67,530,738

G

interleukin 4

disease_progression

protein:increased expression:blood

PMID:10404069 PMID:12097255 PMID:19957810

RGD:2317261 RGD:2317265 RGD:2317267

NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365

G

interleukin 4 receptor

disease_progression

protein:increased expression:pancreas

NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544

G

interleukin 6

disease_progression

PMID:30304975 PMID:30610790

RGD:14975253 RGD:14975257

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

integrin linked kinase

DNA:mutations:exon

NCBI chr 9:3,145,647...3,152,097
Ensembl chr 9:3,145,608...3,159,858

G

inositol polyphosphate-4-phosphatase type II B

CTD Direct Evidence: marker/mechanism

NCBI chr 8:84,812,041...85,555,200
Ensembl chr 8:85,084,133...85,514,516

G

insulin

susceptibility
disease_progression

associated with Diabetes Mellitus, Non-Insulin-Depend
DNA:Polymorphism:promoter:-23 HphI (human)

PMID:19152242 PMID:19375425 PMID:19572116 PMID:19628082

RGD:2317245 RGD:2317247 RGD:2317250 RGD:2317253

NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841

G

integrin subunit alpha 11

DNA:mutations:exon

NCBI chr 1:166,186,601...166,311,046
Ensembl chr 1:166,186,613...166,310,800

G

integrin subunit alpha 4

DNA:mutations:exon

NCBI chr15:86,942,054...87,028,428
Ensembl chr15:86,947,240...87,030,364

G

integrin subunit alpha 9

DNA:mutations:exon

NCBI chr13:22,298,497...22,655,717
Ensembl chr13:22,268,503...22,655,704

G

kinase insert domain receptor

CTD Direct Evidence: therapeutic

PMID:12385004 PMID:19930156

NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336

G

KLF transcription factor 5

CTD Direct Evidence: marker/mechanism

NCBI chr11:45,370,009...45,386,673
Ensembl chr11:45,369,810...45,388,314

G

KRAS proto-oncogene, GTPase

disease_progression

NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358

G

L1 cell adhesion molecule

treatment

NCBI chr X:124,595,649...124,618,292
Ensembl chr X:124,595,651...124,618,269

G

lactate dehydrogenase A

CTD Direct Evidence: marker/mechanism

NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715

G

DNA ligase 3

resistance

DNA:SNP:intron:rs 2074522 (human)

NCBI chr12:40,153,105...40,205,077
Ensembl chr12:40,153,397...40,183,622

G

DNA ligase 4

susceptibility

associated with Diabetes Mellitus;DNA:polymorphism: :54C>T (human)

NCBI chr11:75,537,027...75,547,711
Ensembl chr11:75,537,036...75,547,716

G

arylamine N-acetyltransferase 1

susceptibility

DNA:polymorphisms,haplotype: :
DNA:polymorphism (human)

PMID:18006927 PMID:18499698

RGD:2317168 RGD:2317170

NCBI chr17:13,383,478...13,393,287

G

uncharacterized LOC100519934

CTD Direct Evidence: marker/mechanism

NCBI chr 1:73,119,758...73,124,368

G

mesothelin

associated with Pancreatic Disease; protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism

PMID:11751476 PMID:17019794 PMID:17785569 PMID:18281514 PMID:19843662

RGD:2326052 RGD:2326056 RGD:2326060 RGD:2326062

NCBI chr 3:41,025,892...41,029,302

G

glutathione S-transferase P-like

susceptibility

DNA:SNP:cds:p.I105V (rs1695) (human)

PMID:19536452 PMID:19786118

RGD:2317804 RGD:2317805

NCBI chr 2:5,005,498...5,009,247

G

interleukin-1 beta-like

susceptibility

DNA:polymorphisms:promoter:-511C>T, -31T>C (human)
protein:increased expression:serum (human)

PMID:7787209 PMID:19251436

RGD:2311069 RGD:2317215

G

lumican

disease_progression

DNA:SNP: :rs2268578 (human)

PMID:17671699 PMID:19843670

RGD:2317230 RGD:2317682

NCBI chr 5:91,748,871...91,756,381
Ensembl chr 5:91,748,885...91,757,598

G

lymphocyte antigen 6 family member E

CTD Direct Evidence: marker/mechanism

NCBI chr 4:1,336,112...1,341,112
Ensembl chr 4:1,337,196...1,340,786

G

mesencephalic astrocyte derived neurotrophic factor

no_association

DNA:point mutations, deletions:cds:multiple (human)
DNA:polymorphisms: :multiple (human)

PMID:9174057 PMID:17072959

RGD:2317157 RGD:2325804

NCBI chr13:33,658,279...33,662,218
Ensembl chr13:33,658,255...33,662,261

G

mitogen-activated protein kinase kinase 4

DNA:mutations:exon

NCBI chr12:56,402,029...56,516,217
Ensembl chr12:56,402,075...56,516,238

G

menin 1

associated with Neuroendocrine Tumors; protein:increased expression:multiple organs
CTD Direct Evidence: marker/mechanism

PMID:17278096 PMID:17961653 PMID:21252315

NCBI chr 2:7,358,130...7,364,952
Ensembl chr 2:7,358,218...7,364,952

G

MET proto-oncogene, receptor tyrosine kinase

severity

mRNA:increased expression:pancreas (human)
protein:increased expression:pancreas (rat)

PMID:9211490 PMID:15448002

RGD:2317235 RGD:2317613

NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,048...29,541,512

G

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

NCBI chr 3:55,560,076...55,667,221
Ensembl chr 3:55,560,118...55,666,193

G

O-6-methylguanine-DNA methyltransferase

protein:decreased expression:neuroendocrine tumor (human)

NCBI chr14:138,502,005...138,771,543
Ensembl chr14:138,499,309...138,771,540

G

microRNA mir-107

severity

NCBI chr14:101,420,743...101,420,829
Ensembl chr14:101,420,743...101,420,829

G

marker of proliferation Ki-67

disease_progression

protein:increased expression:pancreas

PMID:20137856 PMID:20350215

RGD:2317703 RGD:2317704

NCBI chr14:137,266,622...137,296,312

G

matrix metallopeptidase 2

mRNA:increased expression:pancreas
protein:increased activity:pancreatic juice
CTD Direct Evidence: marker/mechanism

PMID:7635566 PMID:11961486 PMID:30603057

RGD:2325752 RGD:2325766

NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982

G

matrix metallopeptidase 9

disease_progression

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:pancreas
protein:increased expression:serum

PMID:7635566 PMID:18030366 PMID:18445772 PMID:19629003 PMID:22952646

RGD:2325766 RGD:2325831 RGD:2325849 RGD:2325854

NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788

G

myeloperoxidase

resistance

DNA:polymorphism:promoter:-463G>A (human)

NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904

G

methylthioadenosine phosphorylase

DNA, protein:deletion, decreased activity:pancreas:

NCBI chr 1:200,882,954...200,934,389
Ensembl chr 1:200,882,956...200,934,445

G

methylenetetrahydrofolate reductase

susceptibility

DNA:polymorphism: :677C>T (human)

NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820

G

mechanistic target of rapamycin kinase

NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888

G

5-methyltetrahydrofolate-homocysteine methyltransferase

susceptibility
no_association

DNA:Polymorphism: :rs1805087 (human)

PMID:16737574 PMID:18843018

RGD:2317118 RGD:2317120

NCBI chr14:54,546,978...54,652,780
Ensembl chr14:54,546,978...54,652,763

G

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

susceptibility

DNA:polymorphism: :66A>G (human)
DNA:SNPs:intron, exon:rs162049, p.H595Y (rs10380) (human)

PMID:18515090 PMID:18843018

RGD:2317118 RGD:2325772

NCBI chr16:74,245,214...74,270,828
Ensembl chr16:74,245,228...74,270,783

G

mucin 1, cell surface associated

disease_progression

protein:increased expression:pancreas
protein:increased secretion:bile

PMID:14654947 PMID:18039393 PMID:18383873 PMID:18575732 PMID:19055478 More...

RGD:2317984 RGD:2317987 RGD:2324622 RGD:2324635 RGD:2324637 RGD:2324639

NCBI chr 4:94,626,317...94,631,194

G

mucin 4, cell surface associated

disease_progression

protein:increased expression:pancreas
mRNA:increased expression:pancreas
mRNA:increased expression:peripheral blood mononuclear cell

PMID:11751498 PMID:16274046 PMID:17406026 PMID:17595659 PMID:20303649

RGD:2324891 RGD:2324914 RGD:2324922 RGD:2324923 RGD:2324931

NCBI chr13:134,192,412...134,248,435

G

mucin 5AC, oligomeric mucus/gel-forming

protein:increased glycosylation:serum
protein:increased expression:pancreas

PMID:14654947 PMID:19377061

RGD:2317984 RGD:2325129

NCBI chr 2:757,897...790,321

G

mucin 6, oligomeric mucus/gel-forming

protein:increased expression: :

NCBI chr 2:630,075...657,967
Ensembl chr 2:629,796...655,380

G

MYC proto-oncogene, bHLH transcription factor

CTD Direct Evidence: marker/mechanism

PMID:22024988 PMID:25961927

NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078

G

nucleosome assembly protein 1 like 1

human gene in a mouse model

NCBI chr 5:39,329,628...39,363,699
Ensembl chr 5:39,328,052...39,363,711

G

neural cell adhesion molecule 1

disease_progression
severity

PMID:10374842 PMID:11249065

RGD:2326074 RGD:2326075

NCBI chr 9:40,628,602...40,960,605
Ensembl chr 9:40,628,631...40,960,591

G

NFKB inhibitor alpha

CTD Direct Evidence: therapeutic

NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277

G

nerve growth factor receptor

severity

mRNA:increased expression:tumor:associated with longer overall survival

NCBI chr12:25,699,410...25,720,355
Ensembl chr12:25,699,427...25,720,356

G

nitric oxide synthase 2

disease_progression

protein:increased expression:pancreas

PMID:11196200 PMID:11687972 PMID:15165031

RGD:2325248 RGD:2325257 RGD:2325262

NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146

G

notch receptor 1

disease_progression

protein:increased expression:pancreas

G

nuclear receptor subfamily 5 group A member 2

CTD Direct Evidence: marker/mechanism

PMID:20101243 PMID:26098869

NCBI chr10:22,727,865...22,866,905
Ensembl chr10:22,715,735...22,865,364

G

neuropilin 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:56,280,673...56,430,832
Ensembl chr10:56,280,665...56,430,777

G

neurotrophic receptor tyrosine kinase 1

severity

mRNA:increased expression:tumor:associated with increased tumor aggressiveness

NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,255,981

G

NUF2 component of NDC80 kinetochore complex

treatment

mRNA:increased expression:pancreas

PMID:25370920 PMID:26045769

RGD:11058437 RGD:28867232

NCBI chr 4:87,162,873...87,194,193
Ensembl chr 4:87,162,818...87,194,170

G

8-oxoguanine DNA glycosylase

disease_progression

DNA:polymorphism: :2657G>A (human)
DNA:polymorphism: :rs1052133 (human)

PMID:17230526 PMID:18559563

RGD:2317130 RGD:2317132

NCBI chr13:66,038,669...66,045,478

G

partner and localizer of BRCA2

susceptibility

ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 1 | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3

PMID:100849 PMID:9536098 PMID:16199547 PMID:17200668 PMID:17200671 More...

NCBI chr 3:22,586,881...22,612,837
Ensembl chr 3:22,586,856...22,612,834

G

palladin, cytoskeletal associated protein

susceptibility

ClinVar Annotator: match by term: PALLD-related condition | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1
ClinVar Annotator: match by term: PALLD-related condition | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1

PMID:10454945 PMID:11474289 PMID:17194196 PMID:17415588 PMID:24033266 More...

NCBI chr14:20,678,456...21,020,125
Ensembl chr14:20,678,452...21,020,125

G

platelet derived growth factor receptor alpha

mRNA:increased expression:pancreas

PMID:7665222 PMID:14695158

RGD:2324850 RGD:2324851

NCBI chr 8:40,966,568...41,021,440
Ensembl chr 8:40,967,493...41,021,441

G

pancreatic and duodenal homeobox 1

CTD Direct Evidence: marker/mechanism

PMID:19077462 PMID:25086665 PMID:26098869

NCBI chr11:5,303,609...5,309,063
Ensembl chr11:5,303,609...5,309,063

G

profilin 1

NCBI chr12:51,962,642...51,965,570
Ensembl chr12:51,961,952...51,965,464

G

plasminogen activator, urokinase

CTD Direct Evidence: marker/mechanism

NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172

G

DNA polymerase beta

disease_progression

DNA:polymorphisms: :165A>G, 2133T>C (human)

NCBI chr17:11,356,130...11,388,122
Ensembl chr17:11,356,129...11,388,821

G

peroxisome proliferator activated receptor delta

disease_progression

NCBI chr 7:31,222,533...31,295,221
Ensembl chr 7:31,222,585...31,295,211

G

peroxisome proliferator activated receptor gamma

susceptibility

DNA:polymorphism: :p.P12A (human)
CTD Direct Evidence: marker/mechanism|therapeutic

PMID:11034103 PMID:11741176 PMID:19152448 PMID:19436234

RGD:2317460 RGD:2317462

NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944

G

patched 1

protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism

PMID:19077462 PMID:19396459

NCBI chr10:26,627,165...26,703,225
Ensembl chr10:26,627,425...26,703,223

G

phosphatase and tensin homolog

CTD Direct Evidence: marker/mechanism

NCBI chr14:99,929,590...100,021,619

G

prostaglandin-endoperoxide synthase 2

susceptibility

mRNA, protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism
DNA:SNPs: :-1195A > G, -765G > C (human)
DNA:polymorphisms: :-1195A>A ,-765G>C (human)

PMID:10485483 PMID:10657949 PMID:15705899 PMID:16820089 PMID:19062735 More...

RGD:2317175 RGD:2317179 RGD:2317184 RGD:5135527

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

parathyroid hormone like hormone

CTD Direct Evidence: marker/mechanism

NCBI chr 5:45,750,968...45,763,421
Ensembl chr 5:45,751,292...45,763,415

G

RAB, member of RAS oncogene family like 3

susceptibility

ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 5 | ClinVar Annotator: match by term: RABL3-related condition

NCBI chr13:139,609,164...139,653,951
Ensembl chr13:139,603,454...139,652,431

G

RAD51 recombinase

protein:increased expression:pancreas (rat)

NCBI chr 1:130,592,414...130,640,326
Ensembl chr 1:130,586,665...130,640,136

G

RAD54 like

DNA:SNP:exon:rs1048771 (human)

NCBI chr 6:165,156,833...165,184,641
Ensembl chr 6:165,152,978...165,184,776

G

RAP1 GTPase activating protein

mRNA:decreased expression:pancreas (human)
CTD Direct Evidence: marker/mechanism

PMID:16424023 PMID:22614916

NCBI chr 6:79,664,486...79,735,361
Ensembl chr 6:79,664,485...79,735,361

G

RB transcriptional corepressor 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:19,186,754...19,317,642
Ensembl chr11:19,186,761...19,317,690

G

RecQ like helicase

DNA:SNP:3'utr:rs13035 (human)
DNA:SNPs:introns

PMID:16540687 PMID:18422747 PMID:19768149

RGD:2317365 RGD:2317369 RGD:2317370

NCBI chr 5:51,953,460...51,995,619
Ensembl chr 5:51,953,451...52,003,740

G

RELA proto-oncogene, NF-kB subunit

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

ret proto-oncogene

disease_progression

protein:increased expression:pancreas

NCBI chr14:61,305,818...61,361,416
Ensembl chr14:61,305,841...61,361,412

G

rhomboid domain containing 1

CTD Direct Evidence: therapeutic

NCBI chr15:128,346,315...128,499,151
Ensembl chr15:128,346,373...128,469,213

G

ribonucleotide reductase regulatory subunit M2

NCBI chr 3:126,357,198...126,367,145
Ensembl chr 3:126,347,819...126,365,644

G

RUNX family transcription factor 3

disease_progression

DNA:hypermethylation, loss of heterozygosity (human)

NCBI chr 6:82,531,203...82,595,044
Ensembl chr 6:82,531,559...82,595,026

G

retinoid X receptor alpha

NCBI chr 1:273,698,842...273,797,622
Ensembl chr 1:273,705,505...273,797,620

G

SEL1L adaptor subunit of ERAD E3 ubiquitin ligase

NCBI chr 7:104,219,628...104,283,250
Ensembl chr 7:104,219,411...104,283,195

G

serpin family A member 1

disease_progression

NCBI chr 7:115,604,282...115,616,915
Ensembl chr 7:115,583,043...115,614,645

G

splicing factor 3b subunit 4

mRNA, protein:decreased expression:pancreas (human)

NCBI chr 4:99,123,564...99,129,218
Ensembl chr 4:99,123,585...99,129,218

G

SIN3-HDAC complex associated factor

CTD Direct Evidence: marker/mechanism

NCBI chr 5:42,930,445...42,963,604
Ensembl chr 5:42,930,521...42,985,144

G

solute carrier family 1 member 5

CTD Direct Evidence: marker/mechanism

NCBI chr 6:52,647,432...52,661,464
Ensembl chr 6:52,647,438...52,661,459

G

solute carrier family 29 member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:39,217,974...39,234,683
Ensembl chr 7:39,218,051...39,234,685

G

solute carrier organic anion transporter family member 2B1

mRNA:decreased expression:pancreas (human)

NCBI chr 9:9,433,978...9,474,248
Ensembl chr 9:9,427,121...9,474,230

G

SMAD family member 2

mRNA:increased expression:pancreas (human)

NCBI chr 1:97,415,360...97,511,388
Ensembl chr 1:97,415,716...97,511,357

G

SMAD family member 3

DNA:mutations:exon

NCBI chr 1:164,998,457...165,124,455
Ensembl chr 1:164,998,103...165,124,449

G

SMAD family member 4

ClinVar Annotator: match by term: Cancer of the pancreas

NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,589,850...100,628,029

G

SMAD family member 7

mRNA:increased expression:pancreas (human)

NCBI chr 1:98,512,800...98,543,924
Ensembl chr 1:98,514,267...98,542,382

G

smoothened, frizzled class receptor

treatment

protein:increased expression:pancreas

PMID:19396459 PMID:19460966 PMID:22859707

RGD:150340554 RGD:2324910 RGD:2324978

NCBI chr18:19,450,730...19,478,796
Ensembl chr18:19,450,743...19,478,898

G

synuclein gamma

NCBI chr14:87,916,353...87,922,111
Ensembl chr14:87,904,659...87,922,095

G

SNW domain containing 1

susceptibility

DNA:snp:intron: T>A (human) (rs1477261)

NCBI chr 7:100,718,298...100,749,414
Ensembl chr 7:100,718,036...100,749,356

G

superoxide dismutase 1

protein:decreased expression:pancreas

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

superoxide dismutase 2

susceptibility
disease_progression

DNA:polymorphism:cds:p.A16V (human)
CTD Direct Evidence: marker/mechanism
protein:decreased expression:pancreas

PMID:11328670 PMID:12499913 PMID:12700280 PMID:17895890 PMID:18205184

RGD:1581235 RGD:2317406 RGD:2317410

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

serine peptidase inhibitor Kazal type 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:149,072,652...149,079,529
Ensembl chr 2:149,071,703...149,079,499

G

secreted phosphoprotein 1

NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340

G

somatostatin

CTD Direct Evidence: therapeutic

NCBI chr13:125,337,560...125,338,742
Ensembl chr13:125,337,418...125,338,850

G

somatostatin receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:61,890,560...61,900,567
Ensembl chr 7:61,890,563...61,894,978

G

somatostatin receptor 2

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:15259086 PMID:17625444 PMID:19917848

NCBI chr12:7,783,401...7,789,483
Ensembl chr12:7,783,431...7,789,488

G

somatostatin receptor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 5:10,581,814...10,593,796
Ensembl chr 5:10,581,912...10,589,982

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

PMID:22348037 PMID:23845849

NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992

G

serine/threonine kinase 11

NCBI chr 2:77,229,888...77,249,322
Ensembl chr 2:77,230,372...77,249,327

G

succinyl-CoA:glutarate-CoA transferase

CTD Direct Evidence: marker/mechanism

NCBI chr18:53,639,588...54,283,272
Ensembl chr18:53,639,872...54,283,251

G

synaptonemal complex protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:105,592,354...105,730,413
Ensembl chr 4:105,591,743...105,730,398

G

transcription factor 7 like 2

DNA:mutations:exon

NCBI chr14:123,343,695...123,547,332
Ensembl chr14:123,343,412...123,546,417

G

telomerase reverse transcriptase

CTD Direct Evidence: marker/mechanism

PMID:25086665 PMID:26098869

NCBI chr16:79,258,591...79,276,421
Ensembl chr16:79,258,591...79,276,421

G

tissue factor pathway inhibitor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:73,684,236...73,694,663
Ensembl chr 9:73,673,535...73,689,095

G

transforming growth factor alpha

mRNA, protein:increased expression:pancreas

PMID:1401070 PMID:17785207

RGD:2317468 RGD:2317473

NCBI chr 3:71,948,232...72,054,257
Ensembl chr 3:71,948,137...72,050,474

G

transforming growth factor beta 1

disease_progression

CTD Direct Evidence: marker/mechanism
protein:increased expression:serum

PMID:16933058 PMID:18787407 PMID:23992306

RGD:2325015 RGD:2325018

NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046

G

transforming growth factor beta receptor 2

disease_progression

mRNA:increased expresssion:pancreas
DNA:mutations:exon
DNA:deletion, frameshift mutations (human)
protein:increased expresssion:pancreas

PMID:9365135 PMID:9850059 PMID:11866987 PMID:18772397

RGD:2317499 RGD:2317501 RGD:2317502 RGD:5490966

NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,490...16,878,160

G

transglutaminase 2

CTD Direct Evidence: marker/mechanism

NCBI chr17:41,186,765...41,221,686
Ensembl chr17:41,186,770...41,221,637

G

thrombospondin 1

disease_progression

DNA:hypermethylation (human)

PMID:10766168 PMID:16757110 PMID:20203415

RGD:2325021 RGD:2325023 RGD:2325028

NCBI chr 1:131,728,781...131,746,098
Ensembl chr 1:131,728,784...131,746,115

G

tumor necrosis factor

CTD Direct Evidence: therapeutic

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

G

TNF superfamily member 10

CTD Direct Evidence: therapeutic

NCBI chr13:111,021,952...111,103,060
Ensembl chr13:110,983,298...111,038,324

G

tumor protein p53

DNA:mutations:exon
CTD Direct Evidence: marker/mechanism

PMID:18772397 PMID:23873029 PMID:26390243

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

tumor protein p53 binding protein 1

NCBI chr 1:127,958,500...128,032,370
Ensembl chr 1:127,959,213...128,028,712

G

tumor protein p63

CTD Direct Evidence: marker/mechanism

NCBI chr13:127,115,990...127,347,082
Ensembl chr13:127,116,105...127,347,068

G

TSC complex subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr 3:39,898,924...39,935,579
Ensembl chr 3:39,898,925...39,937,371

G

thymidylate synthetase

CTD Direct Evidence: marker/mechanism

NCBI chr 6:105,642,730...105,660,279
Ensembl chr 6:105,642,381...105,660,578

G

uridine-cytidine kinase 2

protein:increased expression:pancreatic neoplasm (human)

NCBI chr 4:84,838,793...84,919,231
Ensembl chr 4:84,838,802...84,919,236

G

vascular cell adhesion molecule 1

NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222

G

vascular endothelial growth factor B

CTD Direct Evidence: marker/mechanism

NCBI chr 2:7,872,873...7,876,149
Ensembl chr 2:7,872,870...7,876,118

G

von Hippel-Lindau tumor suppressor

associated with Hippel-Lindau Disease;DNA:missense mutation:exon:p.R238Q (human)
DNA:hypermethylation, deletion:promoter (human)

PMID:9488521 PMID:19690016

RGD:2325169 RGD:2325176

NCBI chr13:66,334,535...66,342,401
Ensembl chr13:66,334,591...66,342,654

G

Wnt family member 9A

DNA:mutations:exon

NCBI chr 2:51,102,757...51,128,346
Ensembl chr 2:51,102,763...51,128,346

G

WT1 transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr 2:28,411,467...28,456,007
Ensembl chr 2:28,411,803...28,455,997

G

XPC complex subunit, DNA damage recognition and repair factor

DNA:polymorphism:intron:AF076952 (human)

NCBI chr13:70,348,841...70,397,194
Ensembl chr13:70,348,864...70,397,772

G

exportin 1

exacerbates

protein:increased expression:pancreas (human)

NCBI chr 3:80,255,016...80,300,260
Ensembl chr 3:80,255,146...80,300,327

G

exportin 5

mRNA:decreased expression:pancreas (mouse)

NCBI chr 7:38,530,704...38,569,558
Ensembl chr 7:38,531,919...38,569,582

G

X-ray repair cross complementing 1

DNA:SNP:exon:rs1799782 (human)

NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,689...50,425,729

G

X-ray repair cross complementing 2

DNA:SNP:exon:rs3218536 (human)
DNA:polymorphism: :p.R188H (human)

PMID:16540687 PMID:17986315

RGD:2317365 RGD:2317507

NCBI chr18:4,808,428...4,834,281
Ensembl chr18:4,808,470...4,835,802

G

X-ray repair cross complementing 3

DNA:SNP:cd:rs861539 (human)

G

zinc and ring finger 3

CTD Direct Evidence: marker/mechanism

PMID:25086665 PMID:26098869

NCBI chr14:46,092,000...46,241,327
Ensembl chr14:46,092,062...46,241,321

pancreatic carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activin A receptor type 1B

ClinVar Annotator: match by term: Carcinoma of pancreas

NCBI chr 5:17,314,322...17,350,726
Ensembl chr 5:17,314,276...17,350,722

G

ATM serine/threonine kinase

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:988733 PMID:1849795 PMID:3338800 PMID:8808599 PMID:9443866 More...

NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,657...36,759,552

G

BRCA1 DNA repair associated

ClinVar Annotator: match by term: Carcinoma of head of pancreas | ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:9150174 PMID:10667592 PMID:10667595 PMID:11802209 PMID:12566964 More...

NCBI chr12:19,788,087...19,854,515
Ensembl chr12:19,786,020...19,854,668

G

BRCA2 DNA repair associated

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8665505 PMID:9150150 PMID:9361038 PMID:9536098 PMID:9585613 More...

NCBI chr11:8,805,950...8,858,128
Ensembl chr11:8,805,913...8,857,793

G

BRCA1 interacting helicase 1

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:16116423 PMID:17033622 PMID:21964575 PMID:25330149 PMID:25741868 More...

NCBI chr12:36,498,138...36,639,847
Ensembl chr12:36,498,138...36,639,847

G

chromosome 9 C11orf65 homolog

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:988733 PMID:1849795 PMID:3338800 PMID:8808599 PMID:9443866 More...

NCBI chr 9:36,768,819...36,855,318
Ensembl chr 9:36,776,897...36,849,710

G

carbonyl reductase 4

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:17194196 PMID:25741868 PMID:28492532

NCBI chr14:20,621,960...20,642,351
Ensembl chr14:20,621,981...20,682,240

G

cyclin dependent kinase inhibitor 1A

NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,354,672...32,363,761

G

cyclin dependent kinase inhibitor 2A

susceptibility

DNA:insertion:cds:p.R112_L113insR (human)

NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854

G

chromodomain helicase DNA binding protein 3

disease_progression

protein:increased expression:pancreas

NCBI chr12:53,135,767...53,163,244
Ensembl chr12:53,139,366...53,163,243

G

checkpoint kinase 2

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:9536098 PMID:10617473 PMID:11053450 PMID:11479205 PMID:11719428 More...

NCBI chr14:45,699,833...45,967,350
Ensembl chr14:45,929,715...45,967,290

G

ERCC excision repair 4, endonuclease catalytic subunit

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8797827 PMID:9579555 PMID:20221251 PMID:21228398 PMID:21612988 More...

NCBI chr 3:29,266,234...29,306,109
Ensembl chr 3:29,269,989...29,306,151

G

FA complementation group G

ClinVar Annotator: match by term: Carcinoma of pancreas

NCBI chr 1:235,871,073...235,879,604
Ensembl chr 1:235,871,075...235,877,974

G

heterogeneous nuclear ribonucleoprotein A2/B1

severity

protein:increased expression:pancreas (rat)

NCBI chr18:46,205,164...46,215,861
Ensembl chr18:46,205,418...46,215,856

G

homeobox B13

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8756292 PMID:15964834 PMID:17138648 PMID:22236224 PMID:22714738 More...

NCBI chr12:24,948,307...24,950,661
Ensembl chr12:24,947,687...24,950,714

G

kinase insert domain receptor

treatment

NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:1875403 PMID:7773929 PMID:8439212 PMID:12110640 PMID:12720172 More...

NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358

G

microRNA mir-155

miRNA:increased expression:serum

NCBI chr13:189,138,822...189,138,902
Ensembl chr13:189,138,822...189,138,902

G

mechanistic target of rapamycin kinase

treatment

NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888

G

MYC proto-oncogene, bHLH transcription factor

OMIM:260350

NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078

G

nibrin

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:9590180 PMID:9590181 PMID:9620777 PMID:10398434 PMID:10799436 More...

NCBI chr 4:46,787,664...46,854,331
Ensembl chr 4:46,787,691...46,874,603

G

partner and localizer of BRCA2

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:17200668 PMID:17200671 PMID:17200672 PMID:20122277 PMID:20412113 More...

NCBI chr 3:22,586,881...22,612,837
Ensembl chr 3:22,586,856...22,612,834

G

palladin, cytoskeletal associated protein

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:17194196 PMID:25741868 PMID:28492532

NCBI chr14:20,678,456...21,020,125
Ensembl chr14:20,678,452...21,020,125

G

DNA polymerase delta 1, catalytic subunit

ClinVar Annotator: match by term: Carcinoma of pancreas

NCBI chr 6:55,247,799...55,272,087
Ensembl chr 6:55,247,880...55,272,085

G

Raf-1 proto-oncogene, serine/threonine kinase

mRNA:increased expression:pancreas (rat)

NCBI chr13:68,581,128...68,657,911
Ensembl chr13:68,580,812...68,657,829

G

RB binding protein 8, endonuclease

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:9811458 PMID:28492532

NCBI chr 6:107,923,921...108,020,067
Ensembl chr 6:107,924,002...108,022,669

G

SMAD family member 4

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8653691 PMID:9582123 PMID:9811934 PMID:10398437 PMID:10764709 More...

NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,589,850...100,628,029

G

serine/threonine kinase 11

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:10362809 PMID:11430832 PMID:15188174 PMID:15800014 PMID:16287113 More...

NCBI chr 2:77,229,888...77,249,322
Ensembl chr 2:77,230,372...77,249,327

G

tumor protein p53

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:1565143 PMID:1565144 PMID:1581912 PMID:1591732 PMID:1631137 More...

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

TSC complex subunit 1

NCBI chr 1:272,636,530...272,685,948
Ensembl chr 1:272,636,532...272,685,951

pancreatic ductal adenocarcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

anterior gradient 2, protein disulphide isomerase family member

protein:increased expression:pancreas

NCBI chr 9:86,042,070...86,053,893
Ensembl chr 9:86,041,369...86,053,857

G

aldo-keto reductase family 7 member A2

protein:increased expression:pancreas

NCBI chr 6:77,754,172...77,761,609
Ensembl chr 6:77,754,174...77,761,667

G

calreticulin

ameliorates

human cells in mouse model
human cells in a mouse model

PMID:29072694 PMID:33028359

RGD:150520160 RGD:150521706

NCBI chr 2:66,098,263...66,102,074
Ensembl chr 2:66,098,229...66,102,132

G

cyclin D1

severity

DNA:snp:exon:c.870G>A (human)
protein:increased expression:pancreas (human)

PMID:22939953 PMID:25470788

RGD:13462050 RGD:13462062

NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296

G

CD59 molecule

disease_progression

protein:increased expression:blood (human)

NCBI chr 2:27,186,587...27,207,303

G

cyclin dependent kinase 4

severity

protein:increased expression:pancreas, islet of Langerhans (human)

NCBI chr 5:23,039,206...23,041,959
Ensembl chr 5:23,038,891...23,042,061

G

E2F transcription factor 1

severity

DNA:amplification: : (human)
protein:increased expression:pancreatic ductal cell, nucleus (human)

PMID:12650514 PMID:17233815 PMID:27573434

RGD:13838735 RGD:13838738 RGD:13838739

NCBI chr17:37,178,587...37,190,118
Ensembl chr17:37,178,599...37,189,883

G

forkhead box M1

disease_progression

NCBI chr 5:67,246,219...67,263,215
Ensembl chr 5:67,245,694...67,263,211
Ensembl chr 5:67,245,694...67,263,211

G

far upstream element binding protein 1

mRNA:increased expression:pancreatic duct (human)

NCBI chr 6:135,281,474...135,319,055
Ensembl chr 6:135,281,521...135,318,714

G

GLI pathogenesis related 2

disease_progression

protein:decreased expression:blood (human)

NCBI chr 1:236,919,821...236,943,828
Ensembl chr 1:236,919,879...236,943,823

G

glutamic-oxaloacetic transaminase 1

treatment

human cells in a mouse model

NCBI chr14:110,608,422...110,635,825
Ensembl chr14:110,608,430...110,635,874

G

heat shock protein family A (Hsp70) member 8

disease_progression

protein:decreased expression:blood (human)

NCBI chr 9:49,982,278...49,986,760
Ensembl chr 9:49,982,284...49,990,508

G

inhibitor of nuclear factor kappa B kinase subunit beta

susceptibility

NCBI chr17:11,289,607...11,348,557
Ensembl chr17:11,289,690...11,348,549

G

Janus kinase 1

mRNA:decreased expression:pancreatic ductal cell (human)

NCBI chr 6:147,320,288...147,567,188
Ensembl chr 6:147,429,056...147,567,182

G

mitogen-activated protein kinase 8

severity
disease_progression

protein:increased phosphorylation:pancreas (mouse)

PMID:23237571 PMID:28837246

RGD:14348974 RGD:14348975

NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874

G

microRNA mir-155

disease_progression

NCBI chr13:189,138,822...189,138,902
Ensembl chr13:189,138,822...189,138,902

G

placental growth factor

severity

associated with obesity

NCBI chr 7:98,149,510...98,162,784
Ensembl chr 7:98,148,994...98,162,741

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

mRNA, protein:increased expression:pancreas (human)

NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099

G

phosphoinositide-3-kinase regulatory subunit 2

severity

human cells in a mouse model

NCBI chr 2:59,637,363...59,652,075
Ensembl chr 2:59,637,371...59,652,073

G

phospholipase D1

severity

protein:increased expression:pancreas (human)

NCBI chr13:110,152,268...110,376,319
Ensembl chr13:110,154,874...110,376,294

G

protein tyrosine phosphatase receptor type B

disease_progression

protein:decreased expression:blood (human)

NCBI chr 5:34,656,460...34,794,838
Ensembl chr 5:34,659,964...34,794,289

G

protein tyrosine phosphatase receptor type M

disease_progression

protein:decreased expression:blood (human)

NCBI chr 6:99,350,301...100,092,966
Ensembl chr 6:99,350,303...100,092,883

G

Rac family small GTPase 1

mRNA, protein:increased expression:pancreas (mouse)
mRNA:increased expression:pancreas (human)

PMID:21684285 PMID:23334332

RGD:14392806 RGD:14392816

NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543

G

RAS like proto-oncogene A

mRNA:increased expression:pancreas (human)

NCBI chr18:54,548,523...54,630,746
Ensembl chr18:54,550,238...54,588,980

G

S100 calcium binding protein A8

disease_progression

protein:increased expression:blood (human)

NCBI chr 4:96,209,670...96,210,603
Ensembl chr 4:96,209,659...96,210,602

G

SMAD family member 2

severity

NCBI chr 1:97,415,360...97,511,388
Ensembl chr 1:97,415,716...97,511,357

G

transforming growth factor beta 1

ameliorates

protein:decreased expression:pancreas (human)

NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046

G

transforming growth factor beta 2

ameliorates

protein:decreased expression:pancreas (human)

NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,539...8,390,341

G

transforming growth factor beta 3

ameliorates

protein:decreased expression:pancreas (human)

NCBI chr 7:99,133,873...99,162,239
Ensembl chr 7:99,133,879...99,162,232

G

transforming growth factor beta receptor 1

ameliorates

human cell line in a mouse model

NCBI chr 1:240,842,735...240,918,267
Ensembl chr 1:240,860,156...240,918,528

G

vascular endothelial growth factor D

protein:increased expression:blood serum (human)

NCBI chr X:11,893,254...11,933,923
Ensembl chr X:11,893,259...11,933,809

G

vanin 1

disease_progression

protein:increased expression:blood (human)

NCBI chr 1:31,003,338...31,023,731
Ensembl chr 1:31,000,255...31,024,505

pancreatic ductal carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

mRNA, protein:increased expression:pancreas

NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703

G

angiotensin converting enzyme 2

protein:decreased expression:pancreas

NCBI chr X:12,099,849...12,152,204
Ensembl chr X:12,093,242...12,151,286

G

ADAM metallopeptidase domain 8

disease_progression

mRNA:increased expression:pancreas

NCBI chr14:141,221,177...141,233,728
Ensembl chr14:141,221,198...141,232,306

G

ADAM metallopeptidase domain 9

disease_progression

protein:altered localization:cytoplasm

NCBI chr15:47,523,768...47,601,722
Ensembl chr15:47,523,771...47,601,710

G

anterior gradient 2, protein disulphide isomerase family member

mRNA:increased expression:pancreas

NCBI chr 9:86,042,070...86,053,893
Ensembl chr 9:86,041,369...86,053,857

G

angiotensin II receptor type 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:88,934,873...88,980,317
Ensembl chr13:88,934,868...88,983,105

G

albumin

disease_progression

NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696

G

annexin A2

disease_progression

mRNA, protein:increased expression, altered localization:pancreas, plasma membrane

PMID:16450333 PMID:19260470

RGD:2317307 RGD:2325731

NCBI chr 1:111,588,721...111,635,064
Ensembl chr 1:111,588,306...111,635,059

G

annexin A5

protein:increased expression:pancreas

NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750

G

arginase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:91,343,987...91,385,911
Ensembl chr 7:91,343,988...91,385,909

G

BMI1 proto-oncogene, polycomb ring finger

protein:increased expression:exocrine pancreas:
protein:increased expression:pancreas

NCBI chr10:52,586,089...52,596,154
Ensembl chr10:52,586,509...52,596,564

G

chromosome 6 C19orf33 homolog

CTD Direct Evidence: marker/mechanism

NCBI chr 6:47,223,077...47,224,230

G

calreticulin

protein:increased expression:pancreatic duct

NCBI chr 2:66,098,263...66,102,074
Ensembl chr 2:66,098,229...66,102,132

G

chromobox 7

disease_progression

protein:decreased expression:pancreas

NCBI chr 5:9,070,312...9,090,467
Ensembl chr 5:9,070,353...9,087,634

G

cholecystokinin A receptor

mRNA:increased expression:pancreatic duct
protein:decreased expression:pancreas

PMID:9239407 PMID:12851875

RGD:4110816 RGD:4110818

NCBI chr 8:20,187,324...20,200,273
Ensembl chr 8:20,188,830...20,199,344

G

cholecystokinin B receptor

protein:decreased expression:pancreas

NCBI chr 9:3,409,222...3,419,513

G

cyclin D1

severity

protein:increased expression:pancreas (human)

NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296

G

CD40 molecule

treatment

protein:increased expression:dendritic cell

PMID:20976171 PMID:21436454 PMID:23983255

RGD:11522743 RGD:5490301 RGD:5490524

NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528

G

cyclin dependent kinase 6

treatment

human cells in a mouse model

NCBI chr 9:72,510,858...72,765,631
Ensembl chr 9:72,518,101...72,764,129

G

cyclin dependent kinase inhibitor 1A

disease_progression

NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,354,672...32,363,761

G

cyclin dependent kinase inhibitor 2A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854

G

claudin 4

NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925

G

C-X-C motif chemokine ligand 11

CTD Direct Evidence: marker/mechanism

NCBI chr 8:71,713,790...71,725,669
Ensembl chr 8:71,713,803...71,725,674

G

DNA methyltransferase 1

disease_progression

CTD Direct Evidence: marker/mechanism
protein:increased expression:pancreas

PMID:19424621 PMID:29844410

NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844

G

DNA methyltransferase 3 beta

disease_progression

NCBI chr17:36,345,715...36,386,076
Ensembl chr17:36,345,816...36,386,072

G

deltex E3 ubiquitin ligase 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:38,559,705...38,599,790
Ensembl chr14:38,560,924...38,599,787

G

deltex E3 ubiquitin ligase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 2:12,197,943...12,237,884
Ensembl chr 2:12,199,231...12,237,615

G

epidermal growth factor

disease_progression

protein:increased expression: :

NCBI chr 8:112,235,607...112,330,062
Ensembl chr 8:112,234,386...112,330,046

G

Fas ligand

protein:increased expression:pancreas, liver

PMID:10547193 PMID:15375495

RGD:2317741 RGD:2317747

NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464

G

fibroblast growth factor 2

disease_progression

PMID:12717266 PMID:18704599

RGD:2317756 RGD:2317758

NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916

G

fascin actin-bundling protein 1

disease_progression

protein:increased expression:pancreas

NCBI chr 3:4,134,173...4,143,275
Ensembl chr 3:4,134,177...4,143,286

G

glycoprotein nmb

CTD Direct Evidence: marker/mechanism

NCBI chr 9:92,037,428...92,071,501
Ensembl chr 9:92,037,509...92,071,499

G

histone deacetylase 1

disease_progression

protein:increased expression:pancreas

NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,411

G

HEAT repeat containing 1

treatment

NCBI chr14:54,821,073...54,870,873
Ensembl chr14:54,821,171...54,869,857

G

hes family bHLH transcription factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:131,135,970...131,137,865
Ensembl chr13:131,135,725...131,138,237

G

hes related family bHLH transcription factor with YRPW motif 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:56,859,640...56,863,807
Ensembl chr 4:56,859,663...56,863,788

G

hes related family bHLH transcription factor with YRPW motif 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:37,219,887...37,231,321
Ensembl chr 1:37,219,883...37,231,385

G

insulin like growth factor 1

NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033

G

insulin like growth factor 1 receptor

protein:increased expression:pancreas

PMID:14506643 PMID:14627343

RGD:2317649 RGD:2317652

NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,825...137,691,058

G

interleukin 4

NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365

G

interleukin 4 receptor

protein:increased expression:pancreas

NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544

G

insulin

Glucagon/insulin

NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841

G

jagged canonical Notch ligand 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:19,591,248...19,629,659
Ensembl chr17:19,591,259...19,629,641

G

jagged canonical Notch ligand 2

CTD Direct Evidence: marker/mechanism

G

lysine demethylase 2B

severity

mRNA, protein:increased expression:pancreas (human)

NCBI chr14:31,057,121...31,203,093
Ensembl chr14:31,165,950...31,203,091

G

KIT ligand

CTD Direct Evidence: marker/mechanism

NCBI chr 5:94,016,992...94,110,219
Ensembl chr 5:94,017,387...94,110,214

G

KRAS proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism

PMID:25347530 PMID:30654191

NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358

G

keratin 7

disease_progression

NCBI chr 5:17,553,192...17,570,582
Ensembl chr 5:17,555,728...17,570,581

G

L1 cell adhesion molecule

severity

protein:increased expression:pancreas (human)

NCBI chr X:124,595,649...124,618,292
Ensembl chr X:124,595,651...124,618,269

G

mesothelin

disease_progression

CTD Direct Evidence: marker/mechanism
DNA:hypomethylation:5'UTR
protein:increased secretion:serum

PMID:12874021 PMID:14576474 PMID:19818733 PMID:21775916 PMID:25347530

RGD:2326055 RGD:2326065

NCBI chr 3:41,025,892...41,029,302

G

glutathione S-transferase P-like

resistance

mRNA, protein:increased expression:pancreas
DNA:methylation: :

PMID:12488200 PMID:16537562 PMID:17265526

RGD:2317806 RGD:2317809 RGD:2317811

NCBI chr 2:5,005,498...5,009,247

G

mitogen-activated protein kinase kinase kinase 7

CTD Direct Evidence: marker/mechanism

NCBI chr 1:58,482,046...58,548,087
Ensembl chr 1:58,481,956...58,548,057

G

mitogen-activated protein kinase 3

treatment

human cells in mouse model

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

minichromosome maintenance complex component 7

mRNA, protein:increased expression:pancreatic duct

NCBI chr 3:8,005,890...8,014,047
Ensembl chr 3:8,005,900...8,014,053

G

MDM2 proto-oncogene

onset
severity

DNA:snp:promoter, intron:IVS1+309T>G (human)
protein:increased expression:pancreas (human)

PMID:15810085 PMID:19752772

RGD:2317414 RGD:2317416

NCBI chr 5:33,105,717...33,137,602
Ensembl chr 5:33,105,759...33,137,739

G

menin 1

NCBI chr 2:7,358,130...7,364,952
Ensembl chr 2:7,358,218...7,364,952

G

MET proto-oncogene, receptor tyrosine kinase

protein:increased expression:pancreatic duct (human)

NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,048...29,541,512

G

O-6-methylguanine-DNA methyltransferase

susceptibility

DNA:missense mutation:cds:p.L84F rs12917 (human)
protein:increased activity, increased expression:ductal adenocarcinoma (human)

PMID:9393761 PMID:16844323

RGD:2317648 RGD:2317664

NCBI chr14:138,502,005...138,771,543
Ensembl chr14:138,499,309...138,771,540

G

microRNA mir-142

CTD Direct Evidence: marker/mechanism

NCBI chr12:34,609,378...34,609,457
Ensembl chr12:34,609,364...34,609,468

G

matrix metallopeptidase 2

severity

protein:increased expression:pancreas

NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982

G

matrix metallopeptidase 9

protein:increased expression:blood
protein:increased expression:pancreas, serum

PMID:18706098 PMID:20332475

RGD:2325830 RGD:2325844

NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788

G

mucin 1, cell surface associated

disease_progression

protein:increased expression, altered localization:pancreas

PMID:14681945 PMID:18713982 PMID:19109152

RGD:2317983 RGD:2324616 RGD:2324633

NCBI chr 4:94,626,317...94,631,194

G

mucin 4, cell surface associated

disease_progression

mRNA:increased expression:pancreas
protein:increased expression:pancreas

PMID:12657964 PMID:16049287

RGD:2324942 RGD:2324946

NCBI chr13:134,192,412...134,248,435

G

mucin 5AC, oligomeric mucus/gel-forming

disease_progression

mRNA:increased expression:pancreas

PMID:7657125 PMID:10227724

RGD:2324907 RGD:2324986

NCBI chr 2:757,897...790,321

G

mucin 5B, oligomeric mucus/gel-forming

mRNA:increased expression:pancreas

NCBI chr 2:807,685...842,096

G

N-myc downstream regulated 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:8,014,445...8,069,335
Ensembl chr 4:8,014,446...8,069,335

G

NFE2 like bZIP transcription factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

NME/NM23 nucleoside diphosphate kinase 1

protein:increased expression:pancreas (human)

NCBI chr12:27,416,308...27,435,044
Ensembl chr12:27,416,346...27,436,140

G

nitric oxide synthase 2

NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146

G

notch receptor 1

CTD Direct Evidence: marker/mechanism

PMID:19028876 PMID:19208345 PMID:20484026

RGD:2325323 RGD:2325324

G

notch receptor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 2:62,364,507...62,402,348
Ensembl chr 2:62,364,501...62,402,344

G

notch receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 7:24,231,293...24,256,281
Ensembl chr 7:24,231,293...24,256,281

G

neurotrophic receptor tyrosine kinase 3

disease_progression

protein:increased expression:pancreas

PMID:10209957 PMID:11295066

RGD:2325660 RGD:2325663

NCBI chr 1:191,535,262...191,941,675
Ensembl chr 1:191,535,301...191,925,327

G

oncostatin M

CTD Direct Evidence: marker/mechanism

NCBI chr14:47,242,767...47,246,836
Ensembl chr14:47,242,774...47,246,838

G

palladin, cytoskeletal associated protein

protein:increased expression, alternative form:pancreas, fibroblast

NCBI chr14:20,678,456...21,020,125
Ensembl chr14:20,678,452...21,020,125

G

paired box 6

protein:increased expression:pancreatic duct (human)

NCBI chr 2:28,971,565...29,001,149
Ensembl chr 2:28,978,287...29,001,200

G

PMS1 homolog 1, mismatch repair system component

protein:increased expression:pancreatic duct

NCBI chr15:94,351,603...94,476,505
Ensembl chr15:94,351,630...94,476,506

G

peroxisome proliferator activated receptor gamma

disease_progression

NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944

G

prostaglandin-endoperoxide synthase 2

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

RELA proto-oncogene, NF-kB subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

ring finger protein 2

protein:increased expression:pancreas

NCBI chr 9:126,172,637...126,284,567
Ensembl chr 9:126,172,301...126,287,603

G

retinoid X receptor alpha

severity

NCBI chr 1:273,698,842...273,797,622
Ensembl chr 1:273,705,505...273,797,620

G

serpin family A member 1

mRNA, protein:increased expression:pancreas

NCBI chr 7:115,604,282...115,616,915
Ensembl chr 7:115,583,043...115,614,645

G

solute carrier family 2 member 2

protein:increased expression:pancreatic duct

NCBI chr13:109,592,595...109,614,105
Ensembl chr13:109,587,258...109,638,510

G

SMAD family member 4

disease_progression

NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,589,850...100,628,029

G

smoothened, frizzled class receptor

NCBI chr18:19,450,730...19,478,796
Ensembl chr18:19,450,743...19,478,898

G

serine/threonine kinase 11

CTD Direct Evidence: marker/mechanism

NCBI chr 2:77,229,888...77,249,322
Ensembl chr 2:77,230,372...77,249,327

G

transforming growth factor beta 1

disease_progression

NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046

G

transforming growth factor beta receptor 2

disease_progression

mRNA:increased expresssion:pancreas

PMID:10547197 PMID:17114585

RGD:2317498 RGD:2317500

NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,490...16,878,160

G

thrombospondin 1

disease_progression

DNA:hypermethylation:promoter (human)

PMID:12429967 PMID:19065635

RGD:2325022 RGD:2325025

NCBI chr 1:131,728,781...131,746,098
Ensembl chr 1:131,728,784...131,746,115

G

transmembrane serine protease 3

NCBI chr13:205,707,501...205,733,037
Ensembl chr13:205,709,663...205,732,824

G

tumor protein p53

CTD Direct Evidence: marker/mechanism

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

TSC complex subunit 2

severity

NCBI chr 3:39,898,924...39,935,579
Ensembl chr 3:39,898,925...39,937,371

G

vascular endothelial growth factor A

CTD Direct Evidence: marker/mechanism

NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366

G

von Hippel-Lindau tumor suppressor

DNA:hypermethylation:promoter (human)

NCBI chr13:66,334,535...66,342,401
Ensembl chr13:66,334,591...66,342,654

G

YEATS domain containing 2

CTD Direct Evidence: marker/mechanism

NCBI chr13:121,637,823...121,746,131
Ensembl chr13:121,637,874...121,746,122

G

zinc finger ZZ-type containing 3

CTD Direct Evidence: marker/mechanism

NCBI chr 6:135,605,712...135,746,019
Ensembl chr 6:135,606,192...135,741,487

pancreatic endocrine carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BRCA2 DNA repair associated

ClinVar Annotator: match by term: Neuroendocrine tumor of pancreas

PMID:15145354 PMID:22762150 PMID:25741868 PMID:29446198

NCBI chr11:8,805,950...8,858,128
Ensembl chr11:8,805,913...8,857,793

G

cut like homeobox 1

exacerbates

protein:increased expression:pancreas (human)

NCBI chr 3:9,317,145...9,669,999
Ensembl chr 3:9,317,140...9,669,998

G

death domain associated protein

disease_progression

DNA:frameshift, frameshift mutations, nonsense mutation, missense mutations:CDS:multiple (human)

NCBI chr 7:29,676,854...29,681,145
Ensembl chr 7:29,676,856...29,681,110

G

O-6-methylguanine-DNA methyltransferase

DNA:hypermethylation:promoter (human)

NCBI chr14:138,502,005...138,771,543
Ensembl chr14:138,499,309...138,771,540

G

partner and localizer of BRCA2

ClinVar Annotator: match by term: Neuroendocrine tumor of pancreas

PMID:17200668 PMID:17200671 PMID:17200672 PMID:24136930 PMID:25099575 More...

NCBI chr 3:22,586,881...22,612,837
Ensembl chr 3:22,586,856...22,612,834

G

placental growth factor

treatment
disease_progression

human cells in a mouse model
protein:increased expression:serum (human)

PMID:23463017 PMID:26861455

RGD:14349029 RGD:14349030

NCBI chr 7:98,149,510...98,162,784
Ensembl chr 7:98,148,994...98,162,741

pancreatic intraductal papillary-mucinous neoplasm

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

DNA:missense mutation:cds:p.E17K (human)

G

tumor protein p53

DNA:missense mutations: :multiple

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

vascular endothelial growth factor D

protein:increased expression:blood serum (human)

NCBI chr X:11,893,254...11,933,923
Ensembl chr X:11,893,259...11,933,809

Pancreatic Intraepithelial Neoplasia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

anterior gradient 2, protein disulphide isomerase family member

protein:increased expression:pancreas

NCBI chr 9:86,042,070...86,053,893
Ensembl chr 9:86,041,369...86,053,857

G

BMI1 proto-oncogene, polycomb ring finger

protein:increased expression:exocrine pancreas:
protein:increased expression:pancreatic acinar cell:

NCBI chr10:52,586,089...52,596,154
Ensembl chr10:52,586,509...52,596,564

G

chromobox 7

disease_progression

protein:decreased expression:pancreas

NCBI chr 5:9,070,312...9,090,467
Ensembl chr 5:9,070,353...9,087,634

G

cyclin D1

disease_progression

protein:increased expression:pancreas (human)

PMID:11751405 PMID:12882690

RGD:13462061 RGD:13464129

NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296

G

DNA methyltransferase 1

protein:increased expression:pancreas

NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844

G

histone deacetylase 1

protein:increased expression:pancreas

NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,411

G

inhibitor of nuclear factor kappa B kinase subunit beta

severity
disease_progression

PMID:22056382 PMID:22406536

RGD:13838740 RGD:13838742

NCBI chr17:11,289,607...11,348,557
Ensembl chr17:11,289,690...11,348,549

pancreatic mucinous cystadenoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

KRAS proto-oncogene, GTPase

severity

DNA:mutations:cds:

NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358

pancreatic solid pseudopapillary carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin D1

severity

protein:increased expression:pancreas (human)

NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296

vipoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interferon, alpha 1

CTD Direct Evidence: therapeutic

NCBI chr 1:201,515,835...201,516,477
Ensembl chr 1:201,515,809...201,516,488

G

menin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:7,358,130...7,364,952
Ensembl chr 2:7,358,218...7,364,952

G

somatostatin

CTD Direct Evidence: therapeutic

NCBI chr13:125,337,560...125,338,742
Ensembl chr13:125,337,418...125,338,850

Term paths to the root

Path 1
Term	Annotations
disease	15436
disease of anatomical entity	15105
endocrine system disease	6225
pancreas disease	943
Pancreatic Neoplasms	395
Pancreatic Benign Neoplasm +	14
islet cell tumor +	29
pancreatic cancer +	392

paths to the root