Pancreatic Neoplasms - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Pancreatic Neoplasms	go back to main search page
Accession:	DOID:9003100	browse the term
Synonyms:	exact_synonym:	Pancreas Neoplasms; pancreas neoplasm; pancreatic neoplasm
	narrow_synonym:	Borderline Exocrine Pancreatic Neoplasm
	xref:	EFO:0003860; EFO:1000133; NCI:C34035

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Rat (483) Mouse (506) Human (3225) Chinchilla (383) Bonobo (405) Dog (401) Squirrel (391) Pig (395) Green Monkey (398) Naked Mole-rat (380) All
Genes (398)

Adult Pancreatic Cancer

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism

NCBI chr21:40,778,198...40,826,491
Ensembl chr21:40,778,218...40,826,478

duodenal gastrinoma

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

menin 1

associated with Neuroendocrine Tumors; DNA:loss of heterozygosity: :

NCBI chr 1:9,423,885...9,431,123
Ensembl chr 1:9,423,917...9,431,104

Familial Pancreatic Carcinoma

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apolipoprotein A4

mRNA:increased expression:pancreas, carcinoma (human)

NCBI chr 1:108,186,627...108,190,508
Ensembl chr 1:108,186,921...108,189,698

G

ATM serine/threonine kinase

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:8755918 PMID:9443866 PMID:9463314 PMID:9887333 PMID:10330348 More...

NCBI chr 1:99,653,208...99,786,889
Ensembl chr 1:99,653,139...99,791,520

G

BRCA1 associated RING domain 1

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:25085752 PMID:25741868 PMID:26315354 PMID:26467025 PMID:26787654 More...

NCBI chr10:100,539,827...100,627,718
Ensembl chr10:100,539,527...100,627,675

G

chromosome unknown C11orf65 homolog

ClinVar Annotator: match by term: Familial pancreatic carcinoma

NCBI chr 1:99,804,191...99,879,834
Ensembl chr 1:99,804,218...99,827,182

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:1875403 PMID:2547513 PMID:3627975 PMID:7773929 PMID:8439212 More...

NCBI chr11:24,963,396...25,010,747
Ensembl chr11:24,973,619...25,005,191

G

SMAD family member 4

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:25741868 PMID:26467025 PMID:26900293 PMID:27611364 PMID:28283864 More...

NCBI chr18:29,894,157...29,951,445
Ensembl chr18:29,897,621...29,934,478

G

tumor protein p53

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:1565143 PMID:1565144 PMID:1631137 PMID:1683921 PMID:1978757 More...

NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223

gastrinoma

term browser

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Object Name

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PubMed Reference(s)

RGD Reference(s)

Position

G

insulin like growth factor 1 receptor

mRNA and protein: increased expression::poor prognosis for high expression

NCBI chr29:17,212,206...17,534,036
Ensembl chr29:17,459,404...17,526,930

G

menin 1

DNA:mutations: :
CTD Direct Evidence: marker/mechanism

PMID:15944766 PMID:17961653

NCBI chr 1:9,423,885...9,431,123
Ensembl chr 1:9,423,917...9,431,104

G

MET proto-oncogene, receptor tyrosine kinase

severity

associated with Zollinger-Ellison Syndrome; mRNA:increased expression:tumor (human)

NCBI chr21:85,370,574...85,486,405
Ensembl chr21:85,397,645...85,488,093

G

O-6-methylguanine-DNA methyltransferase

DNA:hypomethylation:promoter (human)

NCBI chr 9:122,089,768...122,376,320

G

solute carrier family 2 member 2

mRNA:decreased expression:pancreatic islet

PMID:8421107 PMID:12114701

RGD:2324976 RGD:2324977

NCBI chr15:18,434,370...18,466,331
Ensembl chr15:18,434,916...18,467,352

Gastro-Enteropancreatic Neuroendocrine Tumor

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Object Name

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PubMed Reference(s)

RGD Reference(s)

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G

ATM serine/threonine kinase

disease_progression

associated with Neoplasm Metastasis;mRNA, protein: decreased expression:gastrointestinal system, multiple (human)

NCBI chr 1:99,653,208...99,786,889
Ensembl chr 1:99,653,139...99,791,520

G

ATRX chromatin remodeler

severity

NCBI chr X:66,449,830...66,737,220
Ensembl chr X:66,448,449...66,737,164

G

CD53 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr20:22,653,361...22,687,172
Ensembl chr20:22,652,819...22,685,287

G

CD86 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr22:58,741,534...58,805,417
Ensembl chr22:58,741,525...58,805,366

G

class II major histocompatibility complex transactivator

CTD Direct Evidence: marker/mechanism

NCBI chr 5:10,341,690...10,401,988
Ensembl chr 5:10,372,344...10,400,451

G

C-X-C motif chemokine receptor 4

severity

protein:increased expression:colon (human)

NCBI chr10:20,336,470...20,340,308
Ensembl chr10:20,336,247...20,340,309

G

death domain associated protein

severity

NCBI chr17:38,754,227...38,758,714
Ensembl chr17:38,754,280...38,759,071

G

eomesodermin

CTD Direct Evidence: marker/mechanism

NCBI chr15:72,257,626...72,264,563

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr 9:8,101,404...8,122,762
Ensembl chr 9:8,101,432...8,123,064

G

growth factor independent 1 transcriptional repressor

CTD Direct Evidence: marker/mechanism

NCBI chr20:40,771,238...40,786,008
Ensembl chr20:40,776,816...40,783,717

G

IKAROS family zinc finger 1

CTD Direct Evidence: marker/mechanism

NCBI chr21:8,398,902...8,500,431
Ensembl chr21:8,402,719...8,484,723

G

IKAROS family zinc finger 3

CTD Direct Evidence: marker/mechanism

NCBI chr16:66,302,107...66,399,152
Ensembl chr16:66,303,117...66,397,765

G

interleukin 10

CTD Direct Evidence: marker/mechanism

NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836

G

interleukin 2 receptor subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr19:19,830,919...19,853,534
Ensembl chr19:19,828,898...19,852,988

G

notch receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr20:13,712,140...13,871,777
Ensembl chr20:13,712,292...13,871,784

G

POU class 2 homeobox 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:36,292,252...36,382,354
Ensembl chr 6:36,295,275...36,336,013

G

protein tyrosine phosphatase receptor type C

CTD Direct Evidence: marker/mechanism

NCBI chr25:30,655,014...30,777,367
Ensembl chr25:30,653,044...30,777,303

G

RUNX family transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr20:107,769,244...107,802,154
Ensembl chr20:107,736,683...107,802,307

G

serpin family A member 1

CTD Direct Evidence: marker/mechanism

NCBI chr24:72,158,521...72,171,139
Ensembl chr24:72,156,784...72,163,500

Glucagonoma

term browser

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RGD Reference(s)

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G

betacellulin

protein:increased expression:pancreas

NCBI chr 7:23,283,269...23,333,373
Ensembl chr 7:23,281,862...23,308,287

G

menin 1

CTD Direct Evidence: marker/mechanism
DNA:deletion:exon

PMID:17961653 PMID:20138042

NCBI chr 1:9,423,885...9,431,123
Ensembl chr 1:9,423,917...9,431,104

G

solute carrier family 2 member 2

mRNA:decreased expression:pancreatic islet

PMID:8421107 PMID:12114701

RGD:2324976 RGD:2324977

NCBI chr15:18,434,370...18,466,331
Ensembl chr15:18,434,916...18,467,352

G

somatostatin receptor 4

NCBI chr 2:52,027,241...52,034,777
Ensembl chr 2:52,031,021...52,032,187

insulinoma

term browser

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Object Name

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PubMed Reference(s)

RGD Reference(s)

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G

adrenomedullin

protein:increased expression:pancreas, plasma

NCBI chr 1:54,518,359...54,520,683
Ensembl chr 1:54,518,358...54,520,686

G

betacellulin

protein:increased expression:pancreas

NCBI chr 7:23,283,269...23,333,373
Ensembl chr 7:23,281,862...23,308,287

G

CD40 molecule

NCBI chr 2:17,753,713...17,765,134
Ensembl chr 2:17,753,394...17,764,566

G

cut like homeobox 1

disease_progression
exacerbates

mRNA:increased expression:pancreas (mouse)
protein:increased expression:pancreas (human)

NCBI chr28:10,901,529...11,370,834
Ensembl chr28:10,937,512...11,370,702

G

C-X-C motif chemokine ligand 12

protein:increased expression:pancreas

NCBI chr 9:40,005,580...40,020,513
Ensembl chr 9:40,011,439...40,020,494

G

insulin

protein:altered expression:blood
protein:altered localization:pancreas

PMID:2565624 PMID:8175958

RGD:2317266 RGD:2317268

NCBI chr 1:1,965,128...1,969,090

G

menin 1

disease_progression

DNA:deletion:exon
DNA:deletions:exons
CTD Direct Evidence: marker/mechanism

PMID:12941803 PMID:17961653 PMID:19208834 PMID:20138042

RGD:2317288 RGD:2317292 RGD:2317310

NCBI chr 1:9,423,885...9,431,123
Ensembl chr 1:9,423,917...9,431,104

G

neural cell adhesion molecule 1

protein:increased expression:pancreas

NCBI chr 1:104,332,622...104,647,258

G

ribosomal protein S15

NCBI chr 6:1,211,716...1,213,896
Ensembl chr 6:1,211,713...1,214,044

G

solute carrier family 2 member 2

mRNA:decreased expression:pancreatic islet
protein:increased expression:pancreatic B cell

PMID:8421107 PMID:12114701

RGD:2324976 RGD:2324977

NCBI chr15:18,434,370...18,466,331
Ensembl chr15:18,434,916...18,467,352

G

transforming growth factor alpha

protein:increased expression:pancreas

NCBI chr14:36,545,641...36,654,213
Ensembl chr14:36,545,875...36,648,237

G

transforming growth factor beta 1

mRNA, protein:decreased expression:pancreatic islet

NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365

Islet Cell Adenomatosis

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PubMed Reference(s)

RGD Reference(s)

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G

MAF bZIP transcription factor A

ClinVar Annotator: match by term: Islet cell adenomatosis

PMID:25741868 PMID:29339498 PMID:35406570

NCBI chr 8:137,647,459...137,650,169
Ensembl chr 8:137,648,746...137,649,804

islet cell tumor

term browser

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Source

PubMed Reference(s)

RGD Reference(s)

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G

ATRX chromatin remodeler

disease_progression

protein:decreased expression:pancreas:

NCBI chr X:66,449,830...66,737,220
Ensembl chr X:66,448,449...66,737,164

G

cyclin dependent kinase 4

protein:increased expression:pancreas, islet of Langerhans (human)

NCBI chr11:53,661,877...53,665,688
Ensembl chr11:53,659,336...53,664,861

G

death domain associated protein

disease_progression

NCBI chr17:38,754,227...38,758,714
Ensembl chr17:38,754,280...38,759,071

G

proprotein convertase subtilisin/kexin type 1

protein:increased expression:insulinoma (rat)

NCBI chr 4:90,246,413...90,289,148
Ensembl chr 4:90,248,598...90,289,089

Islet Cell Tumor Syndrome

term browser

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Object Name

Qualifiers

Evidence

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Source

PubMed Reference(s)

RGD Reference(s)

Position

G

farnesyltransferase, CAAX box, subunit beta

ClinVar Annotator: match by term: Chromaffinoma

NCBI chr24:42,197,998...42,275,863
Ensembl chr24:42,198,704...42,276,898

G

MYC associated factor X

ClinVar Annotator: match by term: Chromaffinoma

PMID:21685915 PMID:22452945 PMID:23666964 PMID:25741868 PMID:26070438 More...

NCBI chr24:42,288,891...42,314,711
Ensembl chr24:42,291,106...42,314,605

G

myelin protein zero

ClinVar Annotator: match by term: Chromaffinoma

PMID:12807974 PMID:17468193 PMID:19454582 PMID:23342407 PMID:24033266 More...

NCBI chr20:2,662,163...2,668,393
Ensembl chr20:2,665,737...2,668,393

G

neurofibromin 1

ClinVar Annotator: match by term: Chromaffinoma

PMID:1568247 PMID:8264648 PMID:8499944 PMID:8499945 PMID:8669813 More...

NCBI chr16:24,550,983...24,836,311
Ensembl chr16:24,550,977...24,836,307

G

ret proto-oncogene

ClinVar Annotator: match by term: Chromaffinoma

PMID:2008030 PMID:2660074 PMID:2904651 PMID:3078962 PMID:7536460 More...

NCBI chr 9:38,746,088...38,798,773
Ensembl chr 9:38,769,170...38,796,712

G

succinate dehydrogenase complex assembly factor 2

ClinVar Annotator: match by term: Chromaffinoma

NCBI chr 1:12,401,164...12,417,389
Ensembl chr 1:12,398,920...12,417,383

G

succinate dehydrogenase complex iron sulfur subunit B

ClinVar Annotator: match by term: Chromaffinoma

PMID:490809 PMID:2308387 PMID:9509062 PMID:9536098 PMID:11404820 More...

NCBI chr20:115,537,880...115,571,150
Ensembl chr20:115,538,026...115,571,142

G

succinate dehydrogenase complex subunit C

ClinVar Annotator: match by term: Chromaffinoma

PMID:12807974 PMID:17468193 PMID:19454582 PMID:22517554 PMID:22703879 More...

NCBI chr20:2,613,618...2,658,374

G

succinate dehydrogenase complex subunit D

ClinVar Annotator: match by term: Chromaffinoma

PMID:1945482 PMID:8981955 PMID:9536098 PMID:9683583 PMID:10323245 More...

NCBI chr 1:103,443,666...103,452,681

G

transmembrane protein 127

ClinVar Annotator: match by term: Chromaffinoma

PMID:9536098 PMID:16266984 PMID:17576681 PMID:20154675 PMID:20923864 More...

NCBI chr14:671,259...685,217
Ensembl chr14:673,375...685,228

G

von Hippel-Lindau tumor suppressor

ClinVar Annotator: match by term: Chromaffinoma

PMID:7563486 PMID:7987306 PMID:8707293 PMID:8772572 PMID:8956040 More...

NCBI chr22:46,184,621...46,203,065
Ensembl chr22:46,184,756...46,204,428

non-functioning pancreatic endocrine tumor

term browser

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Object Name

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Evidence

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Source

PubMed Reference(s)

RGD Reference(s)

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G

AT-rich interaction domain 1A

exacerbates

protein:decreased expression:endocrine pancreas (human)

NCBI chr20:105,981,549...106,066,093
Ensembl chr20:105,981,290...106,065,672

G

cyclin dependent kinase 4

associated with multiple endocrine neoplasia type 1;mRNA:increased expression:islet of Langerhans (human)

NCBI chr11:53,661,877...53,665,688
Ensembl chr11:53,659,336...53,664,861

G

cyclin dependent kinase 6

associated with multiple endocrine neoplasia type 1;mRNA:increased expression:islet of Langerhans (human)

NCBI chr21:56,167,731...56,403,976
Ensembl chr21:56,170,450...56,393,808

pancreatic acinar cell adenocarcinoma

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

B-Raf proto-oncogene, serine/threonine kinase

DNA:missense mutation, gene fusions:multiple (human)

NCBI chr21:109,495,525...109,690,261

G

SRC proto-oncogene, non-receptor tyrosine kinase

disease_progression

NCBI chr 2:26,344,480...26,367,448
Ensembl chr 2:26,343,450...26,367,776

pancreatic adenocarcinoma

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 3

severity

mRNA:increased expression:pancreas (human)

NCBI chr25:80,509,701...80,878,792
Ensembl chr25:80,515,168...80,816,018

G

baculoviral IAP repeat containing 2

exacerbates

mRNA:increased expression:pancreas (human)

NCBI chr 1:93,721,449...93,746,638

G

baculoviral IAP repeat containing 3

disease_progression

mRNA:increased expression:pancreas (human)

NCBI chr 1:93,692,239...93,711,905

G

baculoviral IAP repeat containing 5

exacerbates

mRNA:increased expression:pancreas (human)

NCBI chr16:70,226,824...70,237,000

G

baculoviral IAP repeat containing 7

exacerbates

mRNA:increased expression:pancreas (human)

NCBI chr 2:965,811...970,983

G

carbonyl reductase 4

ClinVar Annotator: match by term: Pancreatic adenocarcinoma

PMID:9536098 PMID:17576681 PMID:25741868 PMID:28166811 PMID:28492532

NCBI chr 7:115,223,813...115,246,925
Ensembl chr 7:115,223,386...115,246,818

G

cyclin D1

severity

protein:increased expression:pancreas (human)

NCBI chr 1:4,909,616...4,922,272
Ensembl chr 1:4,907,353...4,922,357

G

cyclin dependent kinase 4

treatment

human cells in a mouse model

NCBI chr11:53,661,877...53,665,688
Ensembl chr11:53,659,336...53,664,861

G

cyclin dependent kinase 6

treatment

human cells in a mouse model

NCBI chr21:56,167,731...56,403,976
Ensembl chr21:56,170,450...56,393,808

G

C-X-C motif chemokine receptor 4

NCBI chr10:20,336,470...20,340,308
Ensembl chr10:20,336,247...20,340,309

G

E2F transcription factor 1

treatment

Human cells in a mouse model

NCBI chr 2:37,968,541...37,980,461
Ensembl chr 2:37,968,556...37,980,326

G

histidine rich glycoprotein

disease_progression

NCBI chr15:2,753,819...2,766,946
Ensembl chr15:2,753,810...2,766,478

G

Janus kinase 1

treatment

human cell line in a mouse model

NCBI chr20:68,122,134...68,253,361
Ensembl chr20:68,122,173...68,252,042

G

adhesion G protein-coupled receptor B1

mRNA:decreased expression:pancreas

NCBI chr 8:136,704,318...136,784,581
Ensembl chr 8:136,704,341...136,783,991

G

mitogen-activated protein kinase kinase 1

treatment
severity

human tissue in a mouse model
protein:increased expression:pancreas (human)

PMID:19513748 PMID:28849200

RGD:13838804 RGD:13838840

NCBI chr26:17,059,122...17,168,787
Ensembl chr26:17,060,054...17,168,782

G

mitogen-activated protein kinase 1

severity

mRNA:increased expression:pancreas (human)

NCBI chr19:4,246,144...4,352,648
Ensembl chr19:4,246,122...4,353,325

G

mitogen-activated protein kinase 10

severity

DNA:SNP:intron: (rs2589506) (human)

NCBI chr 7:34,394,600...34,725,658
Ensembl chr 7:34,399,544...34,564,212

G

mitogen-activated protein kinase 8

exacerbates

protein:increased phosphorylation:pancreas (human)

NCBI chr 9:43,356,603...43,489,066
Ensembl chr 9:43,356,308...43,393,425

G

mitogen-activated protein kinase 9

NCBI chr23:81,965,330...82,026,414
Ensembl chr23:81,963,899...82,013,659

G

nuclear factor kappa B subunit 1

severity

mRNA:increased expression:pancreas (human)

NCBI chr 7:50,589,494...50,711,472
Ensembl chr 7:50,589,856...50,711,498

G

palladin, cytoskeletal associated protein

ClinVar Annotator: match by term: Pancreatic adenocarcinoma

PMID:9536098 PMID:10454945 PMID:11474289 PMID:17194196 PMID:17415588 More...

NCBI chr 7:114,758,017...115,173,240

G

plasminogen activator, tissue type

mRNA:increased expression:pancreas (human)

NCBI chr 8:40,164,391...40,196,627
Ensembl chr 8:40,163,891...40,196,555

G

Rac family small GTPase 1

treatment

human cells in a mouse model

NCBI chr28:15,583,609...15,610,753
Ensembl chr28:15,583,516...15,610,328

G

Raf-1 proto-oncogene, serine/threonine kinase

treatment

human cells in a mouse model

NCBI chr22:48,560,270...48,643,537
Ensembl chr22:48,561,161...48,618,020

G

RAS like proto-oncogene B

treatment

human cells in a mouse model

NCBI chr10:9,999,828...10,041,158
Ensembl chr10:9,999,904...10,016,473

G

ralA binding protein 1

treatment

human cells in a mouse model

NCBI chr18:68,353,823...68,415,221
Ensembl chr18:68,391,245...68,413,555

G

SMAD family member 7

severity

human cell and construct in a mouse model

NCBI chr18:31,993,543...32,024,088
Ensembl chr18:31,993,681...32,024,850

G

signal transducer and activator of transcription 1

ameliorates

protein:increased expression:pancreas (human)

NCBI chr10:76,492,859...76,537,689
Ensembl chr10:76,492,533...76,533,393

G

vascular endothelial growth factor C

exacerbates

protein:increased expression:pancreas (human)

NCBI chr 7:122,772,539...122,893,486
Ensembl chr 7:122,772,182...122,893,512

pancreatic adenosquamous carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

transforming growth factor beta 2

ameliorates

human cells in a mouse model

NCBI chr25:11,163,651...11,259,868
Ensembl chr25:11,163,100...11,258,470

pancreatic cancer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1,4-N-acetylglucosaminyltransferase

mRNA:increased expression:blood, mononuclear cell

NCBI chr15:52,407,272...52,417,129
Ensembl chr15:52,410,321...52,416,867

G

ATP binding cassette subfamily C member 2

mRNA, protein:increased expression:pancreas

NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265

G

ATP binding cassette subfamily C member 3

severity

mRNA:increased expression:pancreas

NCBI chr16:42,646,316...42,703,124
Ensembl chr16:42,646,812...42,702,852

G

ATP binding cassette subfamily C member 5

mRNA:increased expression:pancreas

NCBI chr15:5,409,921...5,505,334
Ensembl chr15:5,409,861...5,505,315

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

CTD Direct Evidence: marker/mechanism

PMID:19648918 PMID:20103627 PMID:26098869

NCBI chr12:4,863,100...4,892,204
Ensembl chr12:4,863,165...4,885,849

G

activin A receptor type 1

NCBI chr10:43,139,396...43,281,024
Ensembl chr10:43,139,528...43,281,177

G

activin A receptor type 1B

NCBI chr11:48,120,765...48,166,520
Ensembl chr11:48,145,003...48,166,813

G

activin A receptor type 2A

NCBI chr10:33,223,902...33,311,257
Ensembl chr10:33,224,099...33,307,720

G

ADAM metallopeptidase domain 15

mRNA:increased expression:pancreas, epithelial cell

NCBI chr20:8,767,836...8,779,399
Ensembl chr20:8,768,112...8,779,311

G

ADAM metallopeptidase domain 9

mRNA:increased expression:pancreas, epithelial cell

NCBI chr 8:37,017,827...37,131,462
Ensembl chr 8:37,017,545...37,131,615

G

adhesion G protein-coupled receptor E5

protein:increased expression:pancreas

NCBI chr 6:13,022,141...13,054,710
Ensembl chr 6:13,022,115...13,054,112

G

adrenomedullin

disease_progression

PMID:16841081 PMID:17363587

RGD:2325317 RGD:2325318

NCBI chr 1:54,518,359...54,520,683
Ensembl chr 1:54,518,358...54,520,686

G

advanced glycosylation end-product specific receptor

protein:decreased expression:serum

NCBI chr17:39,847,343...39,851,288
Ensembl chr17:39,847,759...39,851,127

G

angiotensin II receptor type 2

mRNA:increased expression:pancreas

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:increased expression:pancreas

PMID:12203118 PMID:25826687

NCBI chr21:40,778,198...40,826,491
Ensembl chr21:40,778,218...40,826,478

G

AKT serine/threonine kinase 1

treatment
severity

human cells in a mouse model
protein:increased phosphorylation:pancreas (human)

PMID:11595724 PMID:20697673

RGD:13450953 RGD:13452388

NCBI chr24:82,704,087...82,730,711
Ensembl chr24:82,704,068...82,727,698

G

albumin

disease_progression

PMID:18154768 PMID:20508721

RGD:2325675 RGD:2325678

NCBI chr 7:21,872,036...21,890,095
Ensembl chr 7:21,876,132...21,891,407

G

aldehyde dehydrogenase 1 family member A1

protein:decreased expression:pancreas

NCBI chr12:83,949,529...84,092,452
Ensembl chr12:83,949,399...84,009,003

G

aldehyde dehydrogenase 2 family member

susceptibility

DNA:polymorphism (human)
DNA:polymorphism: :p.E504K (human)

PMID:15714130 PMID:19068087

RGD:2325313 RGD:2325694

NCBI chr11:107,019,015...107,060,784
Ensembl chr11:107,019,111...107,060,374

G

arachidonate 12-lipoxygenase, 12R type

CTD Direct Evidence: marker/mechanism

NCBI chr16:7,454,950...7,470,949
Ensembl chr16:7,455,044...7,469,934

G

arachidonate 5-lipoxygenase

protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism

PMID:12163367 PMID:12481414 PMID:30258081

RGD:2317523 RGD:2317524

NCBI chr 9:41,085,257...41,145,760
Ensembl chr 9:41,085,361...41,145,331

G

angiogenin

disease_progression

mRNA, protein:increased expression:pancreas, serum

NCBI chr29:21,215,985...21,226,927

G

annexin A1

protein:increased expression:pancreas

PMID:17974280 PMID:19173988

RGD:2325722 RGD:2325723

NCBI chr12:84,207,818...84,226,438
Ensembl chr12:84,207,820...84,226,562

G

annexin A10

CTD Direct Evidence: marker/mechanism

NCBI chr 7:114,287,291...114,449,532
Ensembl chr 7:114,388,038...114,449,277

G

apoptotic peptidase activating factor 1

mRNA:increased expression:pancreas

NCBI chr11:93,942,137...94,024,728
Ensembl chr11:93,942,103...94,024,457

G

APC regulator of WNT signaling pathway

ClinVar Annotator: match by term: Cancer of the pancreas

PMID:1316610 PMID:8381579 PMID:9101302 PMID:9824584 PMID:11852337 More...

NCBI chr23:15,992,437...16,135,117
Ensembl chr23:16,042,287...16,137,067

G

apolipoprotein A1

protein:decreased expression:serum
protein:increased expression:pancreas

PMID:17312459 PMID:17332923

RGD:2325757 RGD:2325758

NCBI chr 1:108,201,967...108,203,902
Ensembl chr 1:108,201,439...108,203,609

G

apolipoprotein E

protein:increased expression:pancreas (human)

NCBI chr 6:38,377,154...38,381,219
Ensembl chr 6:38,376,887...38,381,438

G

actin related protein 2/3 complex subunit 1A

DNA:amplification (human)

NCBI chr28:13,793,196...13,833,254
Ensembl chr28:13,764,945...13,825,815

G

artemin

disease_progression

mRNA:increased expression:pancreas

PMID:19304517 PMID:20395845

RGD:2325815 RGD:2325817

NCBI chr20:88,869,463...88,874,036
Ensembl chr20:88,869,941...88,871,049

G

ATM serine/threonine kinase

susceptibility

DNA:SNP:exon:rs1801516(human)
ClinVar Annotator: match by term: Pancreatic cancer

PMID:8698354 PMID:8845835 PMID:9497252 PMID:9536098 PMID:9792409 More...

NCBI chr 1:99,653,208...99,786,889
Ensembl chr 1:99,653,139...99,791,520

G

ATR serine/threonine kinase

DNA:SNP: :340C>T (human)

NCBI chr15:48,048,785...48,173,120
Ensembl chr15:48,048,882...48,173,137

G

ATRX chromatin remodeler

CTD Direct Evidence: marker/mechanism

NCBI chr X:66,449,830...66,737,220
Ensembl chr X:66,448,449...66,737,164

G

AXL receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 6:35,537,718...35,580,143
Ensembl chr 6:35,537,773...35,580,716

G

beta-1,3-galactosyltransferase 5

mRNA:increased expression:pancreas

NCBI chr 2:83,561,817...83,606,342
Ensembl chr 2:83,603,946...83,604,881

G

BCL2 associated agonist of cell death

treatment

human cells in a mouse model

NCBI chr 1:9,949,717...9,964,433
Ensembl chr 1:9,949,762...9,964,432

G

BAG cochaperone 3

mRNA:increased expression:pancreas

NCBI chr 9:112,439,954...112,465,875
Ensembl chr 9:112,439,782...112,466,086

G

BAG cochaperone 4

mRNA:increased expression:pancreas

NCBI chr 8:36,198,547...36,231,550
Ensembl chr 8:36,198,811...36,231,828

G

BRCA1 associated deubiquitinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr22:13,765,510...13,774,866
Ensembl chr22:13,764,686...13,774,740

G

BCAR1 scaffold protein, Cas family member

CTD Direct Evidence: marker/mechanism

NCBI chr 5:60,709,409...60,749,071
Ensembl chr 5:60,707,006...60,732,882

G

BCL2 like 1

severity

human gene in a mouse model
CTD Direct Evidence: marker/mechanism

PMID:16904634 PMID:17941720

NCBI chr 2:36,059,024...36,118,332
Ensembl chr 2:36,058,919...36,116,470

G

B-Raf proto-oncogene, serine/threonine kinase

disease_progression

human gene in a mouse model

PMID:18490924 PMID:22628411 PMID:22871572

RGD:13451537 RGD:13461863 RGD:13462040

NCBI chr21:109,495,525...109,690,261

G

BRCA1 DNA repair associated

ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4

PMID:1157798 PMID:2173504 PMID:2316185 PMID:2504116 PMID:2618727 More...

NCBI chr16:63,162,827...63,243,928

G

BRCA2 DNA repair associated

susceptibility

ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2
DNA:mutations: :
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2

ClinVar
RGD
OMIM

PMID:186727 PMID:251866 PMID:278235 PMID:1772447 PMID:2200631 More...

NCBI chr 3:11,070,086...11,155,257
Ensembl chr 3:11,071,682...11,155,213

G

basigin (Ok blood group)

CTD Direct Evidence: marker/mechanism

NCBI chr 6:309,579...320,209
Ensembl chr 6:309,506...321,785

G

BUB1 mitotic checkpoint serine/threonine kinase B

protein:altered localization:pancreas

NCBI chr26:42,769,955...42,855,353
Ensembl chr26:42,792,830...42,855,306

G

calcium binding protein 39

disease_progression

NCBI chr10:116,749,173...116,860,814
Ensembl chr10:116,798,825...116,861,332

G

calcyclin binding protein

disease_progression

mRNA, protein:increased expression:pancreas

NCBI chr25:54,246,331...54,258,273
Ensembl chr25:54,247,057...54,257,660

G

cyclase associated actin cytoskeleton regulatory protein 1

disease_progression

mRNA, protein:increased expression:pancreas

NCBI chr20:92,833,112...92,865,258
Ensembl chr20:92,829,735...92,864,697

G

calpain 10

susceptibility

DNA:SNP:intron:rs3792267 (human)

NCBI chr10:126,613,722...126,626,388

G

caspase 8

susceptibility

DNA:SNP: :rs1045485 (human)
DNA:deletion, insertion:promoter (human)

PMID:18483392 PMID:19843670

RGD:2315744 RGD:2317230

NCBI chr10:86,888,654...86,944,159
Ensembl chr10:86,916,527...86,943,829

G

caspase 9

treatment
susceptibility

DNA:snp:promoter:g.-1263A>G (human)

PMID:19209030 PMID:20357690

RGD:13451540 RGD:13462046

NCBI chr20:116,772,819...116,798,402
Ensembl chr20:116,772,155...116,798,930

G

catalase

disease_progression

protein:decreased expression:pancreas

NCBI chr 1:30,792,533...30,828,920
Ensembl chr 1:30,792,399...30,829,592

G

carbonyl reductase 4

ClinVar Annotator: match by term: PALLD-related condition | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1

PMID:25741868 PMID:28492532

NCBI chr 7:115,223,813...115,246,925
Ensembl chr 7:115,223,386...115,246,818

G

cholecystokinin A receptor

mRNA:increased expression:pancreas

PMID:8222074 PMID:10457335

RGD:4110817 RGD:4110822

NCBI chr27:23,855,766...23,866,104
Ensembl chr27:23,856,705...23,865,367

G

cholecystokinin B receptor

disease_progression
susceptibility

mRNA:increased expression:pancreas

PMID:1458479 PMID:8222074 PMID:8302799 PMID:15688412

RGD:4110821 RGD:4110822 RGD:4110823 RGD:4110829

NCBI chr 1:58,555,463...58,569,949
Ensembl chr 1:58,555,321...58,568,031

G

C-C motif chemokine ligand 20

CTD Direct Evidence: marker/mechanism

PMID:10225458 PMID:30603057

NCBI chr10:113,815,099...113,836,562
Ensembl chr10:113,832,573...113,835,736

G

C-C motif chemokine ligand 5

NCBI chr16:29,351,214...29,361,317

G

cyclin D1

treatment
disease_progression

human cells in a mouse model
mRNA, protein:increased expression:pancreas (mouse)

PMID:11159909 PMID:17541034 PMID:22722256

RGD:13451541 RGD:13452385 RGD:13462059

NCBI chr 1:4,909,616...4,922,272
Ensembl chr 1:4,907,353...4,922,357

G

C-C motif chemokine receptor 4

protein:increased expression:pancreas

NCBI chr15:77,435,195...77,439,164
Ensembl chr15:77,437,265...77,438,347

G

C-C motif chemokine receptor 5

NCBI chr22:7,803,794...7,818,112

G

CD24 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr13:66,863,164...66,868,951

G

CD44 molecule (IN blood group)

CTD Direct Evidence: marker/mechanism

NCBI chr 1:30,039,854...30,132,646
Ensembl chr 1:30,039,749...30,132,416

G

cell division cycle 42

severity

mRNA, protein:increased expression:pancreas (human)

NCBI chr20:110,568,004...110,608,318
Ensembl chr20:110,569,352...110,582,562

G

cyclin dependent kinase 4

disease_progression
susceptibility

protein:increased expression:pancreas (mouse)
protein:increased expression:islet of Langerhans (human)
protein:increased expression:islet of Langerhans, nucleus (rat)

PMID:11159909 PMID:22477723 PMID:22761470 PMID:24531709

RGD:13452384 RGD:13452385 RGD:13452386 RGD:13452387

NCBI chr11:53,661,877...53,665,688
Ensembl chr11:53,659,336...53,664,861

G

CASP8 and FADD like apoptosis regulator

CTD Direct Evidence: marker/mechanism

NCBI chr10:86,768,252...86,819,963
Ensembl chr10:86,782,240...86,816,652

G

CF transmembrane conductance regulator

no_association
onset

PMID:16227367 PMID:17072959

RGD:2317156 RGD:2317157

NCBI chr21:86,154,313...86,332,436

G

checkpoint kinase 1

disease_progression

DNA:SNP: :35G>A (human)

NCBI chr 1:116,768,141...116,809,557
Ensembl chr 1:116,767,944...116,801,371

G

claudin 4

PMID:19555390 PMID:19793693

RGD:2317580 RGD:2317583

NCBI chr28:9,242,054...9,244,972
Ensembl chr28:9,242,909...9,243,538

G

CLPTM1 regulator of GABA type A receptor forward trafficking

CTD Direct Evidence: marker/mechanism

NCBI chr 6:38,416,268...38,452,578
Ensembl chr 6:38,415,788...38,452,679

G

cannabinoid receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:12,626,259...12,653,253
Ensembl chr13:12,630,270...12,631,688

G

cannabinoid receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr20:108,777,793...108,815,738
Ensembl chr20:108,813,579...108,814,661

G

catenin beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr22:2,679,488...2,725,034
Ensembl chr22:2,684,022...2,723,949

G

C-X-C motif chemokine ligand 8

CTD Direct Evidence: marker/mechanism

NCBI chr 7:22,202,497...22,205,730
Ensembl chr 7:22,202,527...22,204,068

G

cytochrome P450 family 17 subfamily A member 1

susceptibility

DNA:transition:5' utr:-34T>C rs743572 (human)

NCBI chr 9:95,870,098...95,877,345
Ensembl chr 9:95,866,908...95,877,180

G

death domain associated protein

CTD Direct Evidence: marker/mechanism

NCBI chr17:38,754,227...38,758,714
Ensembl chr17:38,754,280...38,759,071

G

discoidin domain receptor tyrosine kinase 1

treatment

NCBI chr17:41,564,271...41,583,404
Ensembl chr17:41,564,992...41,575,682

G

dihydropyrimidine dehydrogenase

disease_progression

CTD Direct Evidence: marker/mechanism
protein:increased expression:pancreas

PMID:17443278 PMID:18309485 PMID:19020767 PMID:20072795

RGD:2317629 RGD:2317630

NCBI chr20:35,376,738...36,215,388
Ensembl chr20:35,377,266...36,215,679

G

dual specificity tyrosine phosphorylation regulated kinase 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 2:81,318,509...81,467,227
Ensembl chr 2:81,425,902...81,467,677

G

E2F transcription factor 1

treatment

NCBI chr 2:37,968,541...37,980,461
Ensembl chr 2:37,968,556...37,980,326

G

EGF containing fibulin extracellular matrix protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:50,989,553...51,048,149
Ensembl chr14:50,989,795...51,048,708

G

epidermal growth factor

disease_progression

protein:increased expression:pancreas

NCBI chr 7:57,810,110...57,911,361
Ensembl chr 7:57,811,728...57,911,516

G

epidermal growth factor receptor

CTD Direct Evidence: marker/mechanism

PMID:17452677 PMID:27720938

NCBI chr21:3,664,622...3,853,492
Ensembl chr21:3,666,339...3,853,239

G

eukaryotic translation initiation factor 4A3

protein:increased expression:serum (human)

NCBI chr16:72,097,692...72,113,112

G

epithelial cell adhesion molecule

CTD Direct Evidence: marker/mechanism

NCBI chr14:59,815,128...59,832,360
Ensembl chr14:59,815,064...59,832,229

G

EPH receptor A3

NCBI chr22:87,480,220...87,840,628
Ensembl chr22:87,480,126...87,838,512

G

ERCC excision repair 1, endonuclease non-catalytic subunit

susceptibility

DNA:snp:3' utr:c.*197G>T (rs3212986) (human)

NCBI chr 6:38,857,067...38,900,177
Ensembl chr 6:38,854,803...38,872,967

G

ERCC excision repair 2, TFIIH core complex helicase subunit

treatment

DNA,protein:SNPs:exons:rs1799793,rs1052559
pancreatic adenocarcinoma;DNA:SNPs: :rs1799793,rs1052555(human)

PMID:16458430 PMID:18544627 PMID:21404106

RGD:11252206 RGD:2317223 RGD:2317228

NCBI chr 6:38,804,296...38,823,229
Ensembl chr 6:38,801,423...38,823,073

G

ERCC excision repair 4, endonuclease catalytic subunit

pancreatic adenocarcinoma;DNA:SNP: :rs1800067(human)

NCBI chr 5:13,378,282...13,410,307
Ensembl chr 5:13,378,401...13,406,541

G

ETAA1 activator of ATR kinase

CTD Direct Evidence: marker/mechanism

NCBI chr14:39,658,974...39,673,093
Ensembl chr14:39,659,873...39,673,259

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

protein:increased expression:pancreas

NCBI chr21:117,380,518...117,515,224
Ensembl chr21:117,380,361...117,421,573

G

FA complementation group A

DNA,Protein:polymorphisms:exons:c.377C>G, c.661A>G (human)

NCBI chr 5:75,073,161...75,149,110
Ensembl chr 5:75,073,358...75,148,591

G

FA complementation group C

DNA:nonsense mutation (human)

PMID:15695377 PMID:16243825

RGD:2317238 RGD:2317239

NCBI chr12:107,780,087...107,991,828
Ensembl chr12:107,845,135...107,991,237

G

FA complementation group G

NCBI chr12:45,537,817...45,544,038
Ensembl chr12:45,538,303...45,543,766

G

Fas ligand

severity
resistance

DNA:polymorphism:promoter:-844>>T (human)

PMID:11115536 PMID:12370548 PMID:18483392

RGD:2315744 RGD:2317744 RGD:2317745

NCBI chr25:56,488,572...56,496,469
Ensembl chr25:56,489,417...56,496,251

G

fibroblast growth factor 13

CTD Direct Evidence: marker/mechanism

NCBI chr X:113,683,688...114,256,728
Ensembl chr X:113,684,967...113,906,176

G

fibroblast growth factor 2

severity

mRNA:increased expression:pancreas
protein:increased expression:bile

PMID:9293890 PMID:11478488 PMID:11562741 PMID:12670449

RGD:2317759 RGD:2317760 RGD:2317762 RGD:2317765

NCBI chr 7:70,089,394...70,157,423

G

fms related receptor tyrosine kinase 3 ligand

NCBI chr 6:42,653,820...42,665,017
Ensembl chr 6:42,654,412...42,660,458

G

forkhead box P1

CTD Direct Evidence: marker/mechanism

NCBI chr22:31,907,941...32,538,294
Ensembl chr22:31,912,460...32,154,502

G

fascin actin-bundling protein 1

severity

protein:increased expression:pancreas

NCBI chr28:16,127,033...16,142,285
Ensembl chr28:16,127,015...16,142,337

G

FXYD domain containing ion transport regulator 3

CTD Direct Evidence: marker/mechanism

NCBI chr 6:30,047,352...30,057,059
Ensembl chr 6:30,052,066...30,056,026

G

growth arrest and DNA damage inducible alpha

CTD Direct Evidence: therapeutic

NCBI chr20:65,422,668...65,425,845
Ensembl chr20:65,422,451...65,425,840

G

glial cell derived neurotrophic factor

severity

NCBI chr 4:36,662,033...36,691,761
Ensembl chr 4:36,665,009...36,684,257

G

golgi membrane protein 1

NCBI chr12:96,706,865...96,778,687
Ensembl chr12:96,708,548...96,779,065

G

glutathione S-transferase pi 1

susceptibility

DNA:SNP:cds:p.I105V (rs1695) (human)

PMID:19536452 PMID:19786118

RGD:2317804 RGD:2317805

NCBI chr 1:6,676,897...6,679,936

G

hepatocyte growth factor

protein:increased expression:serum

NCBI chr21:67,118,785...67,193,506
Ensembl chr21:67,120,722...67,193,504

G

hypoxia inducible factor 1 subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr24:38,873,830...38,927,657
Ensembl chr24:38,873,861...38,928,288

G

heparan sulfate-glucosamine 3-sulfotransferase 2

DNA:hypermethylation:promoter (human)

NCBI chr 5:20,511,329...20,612,114
Ensembl chr 5:20,511,762...20,611,336

G

heat shock protein family B (small) member 1

disease_progression

NCBI chr28:10,442,530...10,443,804
Ensembl chr28:10,442,398...10,443,855

G

intercellular adhesion molecule 1

mRNA, protein:increased expression:pancreas

NCBI chr 6:9,320,991...9,338,125
Ensembl chr 6:9,322,550...9,338,263

G

interferon alpha 2

CTD Direct Evidence: therapeutic

NCBI chr12:58,468,018...58,469,825

G

interferon gamma

protein:increased expression:plasma

NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473

G

insulin like growth factor 1

susceptibility

DNA:polymorphism (human)

NCBI chr11:97,624,498...97,708,730
Ensembl chr11:97,631,189...97,707,308

G

insulin like growth factor 1 receptor

PMID:14559833 PMID:19732452 PMID:19885860

RGD:2317640 RGD:2317642 RGD:2317651

NCBI chr29:17,212,206...17,534,036
Ensembl chr29:17,459,404...17,526,930

G

interleukin 10

disease_progression
susceptibility

protein:increased expression:serum
DNA:polymorphism: :-1082G>A (human)

PMID:17235586 PMID:19250218 PMID:30304975 PMID:30610790

RGD:14975253 RGD:14975257 RGD:2317653 RGD:2317655

NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836

G

interleukin 13

disease_progression

protein:increased expression:pancreas

PMID:12808442 PMID:18758789

RGD:2317669 RGD:2317670

NCBI chr23:35,475,762...35,479,419
Ensembl chr23:35,476,490...35,478,869

G

interleukin 13 receptor subunit alpha 2

treatment

NCBI chr X:102,589,947...102,628,853
Ensembl chr X:102,590,045...102,603,260

G

interleukin 1 alpha

NCBI chr14:15,789,710...15,801,938
Ensembl chr14:15,789,013...15,796,611

G

interleukin 1 beta

susceptibility

DNA:polymorphisms:promoter:-511C>T, -31T>C (human)
protein:increased expression:serum (human)

PMID:7787209 PMID:19251436

RGD:2311069 RGD:2317215

NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729

G

interleukin 2

treatment

NCBI chr 7:69,729,635...69,736,279
Ensembl chr 7:69,730,282...69,734,969

G

interleukin 24

CTD Direct Evidence: therapeutic

NCBI chr25:22,453,579...22,460,361
Ensembl chr25:22,454,382...22,459,757

G

interleukin 3

protein:increased expression:serum

NCBI chr23:34,894,630...34,899,105

G

interleukin 4

disease_progression

protein:increased expression:blood

PMID:10404069 PMID:12097255 PMID:19957810

RGD:2317261 RGD:2317265 RGD:2317267

NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258

G

interleukin 4 receptor

disease_progression

protein:increased expression:pancreas

NCBI chr 5:25,019,638...25,069,732
Ensembl chr 5:25,046,701...25,070,015

G

interleukin 6

disease_progression

PMID:30304975 PMID:30610790

RGD:14975253 RGD:14975257

NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237

G

integrin linked kinase

DNA:mutations:exon

NCBI chr 1:58,214,630...58,221,770
Ensembl chr 1:58,213,310...58,221,217

G

inositol polyphosphate-4-phosphatase type II B

CTD Direct Evidence: marker/mechanism

NCBI chr 7:88,929,249...89,732,375
Ensembl chr 7:88,979,493...89,461,475

G

insulin

disease_progression
susceptibility

DNA:Polymorphism:promoter:-23 HphI (human)
associated with Diabetes Mellitus
associated with Diabetes Mellitus, Non-Insulin-Depend

PMID:19152242 PMID:19375425 PMID:19572116 PMID:19628082

RGD:2317245 RGD:2317247 RGD:2317250 RGD:2317253

NCBI chr 1:1,965,128...1,969,090

G

integrin subunit alpha 11

DNA:mutations:exon

NCBI chr26:15,045,728...15,178,151
Ensembl chr26:15,046,058...15,176,837

G

integrin subunit alpha 4

DNA:mutations:exon

NCBI chr10:66,984,687...67,063,158
Ensembl chr10:66,984,887...67,061,636

G

integrin subunit alpha 9

DNA:mutations:exon

NCBI chr15:1,585,811...1,961,798
Ensembl chr15:1,581,676...1,961,435

G

kinase insert domain receptor

CTD Direct Evidence: therapeutic

PMID:12385004 PMID:19930156

NCBI chr 7:13,435,059...13,482,236
Ensembl chr 7:13,435,096...13,482,771

G

KLF transcription factor 5

CTD Direct Evidence: marker/mechanism

NCBI chr 3:52,188,139...52,210,882

G

KRAS proto-oncogene, GTPase

disease_progression

NCBI chr11:24,963,396...25,010,747
Ensembl chr11:24,973,619...25,005,191

G

L1 cell adhesion molecule

treatment

NCBI chr X:128,285,128...128,309,173
Ensembl chr X:128,285,130...128,299,570

G

lactate dehydrogenase A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:46,525,090...46,542,587

G

DNA ligase 3

resistance

DNA:SNP:intron:rs 2074522 (human)

NCBI chr16:28,487,953...28,511,945
Ensembl chr16:28,490,434...28,511,130

G

DNA ligase 4

susceptibility

associated with Diabetes Mellitus;DNA:polymorphism: :54C>T (human)

NCBI chr 3:86,576,200...86,587,097
Ensembl chr 3:86,577,304...86,580,039

G

arylamine N-acetyltransferase 1

susceptibility

DNA:polymorphism (human)
DNA:polymorphisms,haplotype: :

PMID:18006927 PMID:18499698

RGD:2317168 RGD:2317170

NCBI chr 8:16,302,296...16,315,406
Ensembl chr 8:16,314,446...16,315,318

G

protein patched homolog 1

CTD Direct Evidence: marker/mechanism
protein:increased expression:pancreas

PMID:19077462 PMID:19396459

NCBI chr12:107,580,895...107,656,443
Ensembl chr12:107,590,663...107,652,985

G

cytochrome c

NCBI chr21:33,251,825...33,253,298

G

uncharacterized LOC103230356

CTD Direct Evidence: marker/mechanism

PMID:20101243 PMID:26098869

NCBI chr25:29,230,358...29,380,617
Ensembl chr25:29,233,558...29,379,922

G

cadherin-1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:58,578,244...58,679,677
Ensembl chr 5:58,578,146...58,679,541

G

mucin-16

protein:increased expression:serum

NCBI chr 6:8,110,087...8,256,015

G

mucin-6

protein:increased expression: :

NCBI chr 1:822,052...858,589

G

mucin-4

disease_progression

mRNA:increased expression:peripheral blood mononuclear cell
mRNA:increased expression:pancreas
protein:increased expression:pancreas

PMID:11751498 PMID:16274046 PMID:17406026 PMID:17595659 PMID:20303649

RGD:2324891 RGD:2324914 RGD:2324922 RGD:2324923 RGD:2324931

NCBI chr15:91,313,060...91,345,172

G

neuroendocrine secretory protein 55

NCBI chr 2:5,233,893...5,303,433
Ensembl chr 2:5,233,874...5,249,192

G

cyclin-G1

treatment

human cells in mouse model

NCBI chr23:65,709,759...65,716,913
Ensembl chr23:65,709,786...65,714,711

G

lumican

disease_progression

DNA:SNP: :rs2268578 (human)

PMID:17671699 PMID:19843670

RGD:2317230 RGD:2317682

NCBI chr11:86,510,824...86,519,008
Ensembl chr11:86,509,722...86,519,010

G

lymphocyte antigen 6 family member E

CTD Direct Evidence: marker/mechanism

NCBI chr 8:137,265,510...137,269,397
Ensembl chr 8:137,265,535...137,269,404

G

mesencephalic astrocyte derived neurotrophic factor

no_association

DNA:polymorphisms: :multiple (human)
DNA:point mutations, deletions:cds:multiple (human)

PMID:9174057 PMID:17072959

RGD:2317157 RGD:2325804

NCBI chr22:12,725,718...12,730,377
Ensembl chr22:12,726,308...12,730,587

G

mitogen-activated protein kinase kinase 4

DNA:mutations:exon

NCBI chr16:11,366,610...11,485,411
Ensembl chr16:11,366,751...11,486,125

G

menin 1

associated with Neuroendocrine Tumors; protein:increased expression:multiple organs
CTD Direct Evidence: marker/mechanism

PMID:17278096 PMID:17961653 PMID:21252315

NCBI chr 1:9,423,885...9,431,123
Ensembl chr 1:9,423,917...9,431,104

G

MET proto-oncogene, receptor tyrosine kinase

severity

mRNA:increased expression:pancreas (human)
protein:increased expression:pancreas (rat)

PMID:9211490 PMID:15448002

RGD:2317235 RGD:2317613

NCBI chr21:85,370,574...85,486,405
Ensembl chr21:85,397,645...85,488,093

G

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

NCBI chr14:2,339,509...2,457,872
Ensembl chr14:2,340,567...2,453,853

G

O-6-methylguanine-DNA methyltransferase

protein:decreased expression:neuroendocrine tumor (human)

NCBI chr 9:122,089,768...122,376,320

G

marker of proliferation Ki-67

disease_progression

protein:increased expression:pancreas

PMID:20137856 PMID:20350215

RGD:2317703 RGD:2317704

NCBI chr 9:120,697,183...120,727,039
Ensembl chr 9:120,698,834...120,726,866

G

matrix metallopeptidase 2

protein:increased activity:pancreatic juice
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:pancreas

PMID:7635566 PMID:11961486 PMID:30603057

RGD:2325752 RGD:2325766

NCBI chr 5:41,264,382...41,291,657
Ensembl chr 5:41,264,354...41,291,004

G

matrix metallopeptidase 9

disease_progression

protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:pancreas

PMID:7635566 PMID:18030366 PMID:18445772 PMID:19629003 PMID:22952646

RGD:2325766 RGD:2325831 RGD:2325849 RGD:2325854

NCBI chr 2:17,867,267...17,874,757
Ensembl chr 2:17,867,177...17,874,712

G

myeloperoxidase

resistance

DNA:polymorphism:promoter:-463G>A (human)

NCBI chr16:35,120,194...35,130,851
Ensembl chr16:35,120,581...35,130,671

G

mesothelin

CTD Direct Evidence: marker/mechanism
associated with Pancreatic Disease; protein:increased expression:pancreas

PMID:11751476 PMID:17019794 PMID:17785569 PMID:18281514 PMID:19843662

RGD:2326052 RGD:2326056 RGD:2326060 RGD:2326062

NCBI chr 5:681,923...690,530
Ensembl chr 5:683,480...690,757

G

methylthioadenosine phosphorylase

DNA, protein:deletion, decreased activity:pancreas:

NCBI chr15:84,196,548...84,198,357
Ensembl chr12:57,997,427...58,050,241

G

methylenetetrahydrofolate reductase

susceptibility

DNA:polymorphism: :677C>T (human)

NCBI chr20:119,987,667...120,003,611
Ensembl chr20:119,990,133...120,002,950

G

mechanistic target of rapamycin kinase

NCBI chr20:120,522,667...120,678,988
Ensembl chr20:120,525,737...120,679,020

G

5-methyltetrahydrofolate-homocysteine methyltransferase

no_association
susceptibility

DNA:Polymorphism: :rs1805087 (human)

PMID:16737574 PMID:18843018

RGD:2317118 RGD:2317120

NCBI chr25:73,935,666...74,039,872
Ensembl chr25:73,935,225...74,038,741

G

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

susceptibility

DNA:polymorphism: :66A>G (human)
DNA:SNPs:intron, exon:rs162049, p.H595Y (rs10380) (human)

PMID:18515090 PMID:18843018

RGD:2317118 RGD:2325772

NCBI chr 4:7,461,521...7,493,032
Ensembl chr 4:7,461,526...7,493,840

G

mucin 1, cell surface associated

disease_progression

protein:increased secretion:bile
protein:increased expression:pancreas

PMID:14654947 PMID:18039393 PMID:18383873 PMID:18575732 PMID:19055478 More...

RGD:2317984 RGD:2317987 RGD:2324622 RGD:2324635 RGD:2324637 RGD:2324639

NCBI chr20:8,641,701...8,646,739
Ensembl chr20:8,642,842...8,646,962

G

mucin 5AC, oligomeric mucus/gel-forming

protein:increased glycosylation:serum
protein:increased expression:pancreas

PMID:14654947 PMID:19377061

RGD:2317984 RGD:2325129

NCBI chr 1:981,515...1,018,242

G

MYC proto-oncogene, bHLH transcription factor

CTD Direct Evidence: marker/mechanism

PMID:22024988 PMID:25961927

NCBI chr 8:122,282,989...122,288,392
Ensembl chr 8:122,282,630...122,288,384

G

nucleosome assembly protein 1 like 1

human gene in a mouse model

NCBI chr11:71,639,965...71,679,131
Ensembl chr11:71,522,837...71,678,825

G

N-acetyltransferase 2

susceptibility

DNA:polymorphism (human)

NCBI chr 8:16,451,144...16,494,961
Ensembl chr 8:16,493,749...16,494,621

G

neural cell adhesion molecule 1

disease_progression
severity

PMID:10374842 PMID:11249065

RGD:2326074 RGD:2326075

NCBI chr 1:104,332,622...104,647,258

G

NFKB inhibitor alpha

CTD Direct Evidence: therapeutic

NCBI chr24:12,211,619...12,216,185
Ensembl chr24:12,210,281...12,214,854

G

nerve growth factor receptor

severity

mRNA:increased expression:tumor:associated with longer overall survival

NCBI chr16:69,894,000...69,914,209
Ensembl chr16:69,894,139...69,912,189

G

nitric oxide synthase 2

disease_progression

protein:increased expression:pancreas

PMID:11196200 PMID:11687972 PMID:15165031

RGD:2325248 RGD:2325257 RGD:2325262

NCBI chr16:21,533,011...21,576,645
Ensembl chr16:21,533,484...21,574,257

G

notch receptor 1

disease_progression

protein:increased expression:pancreas

NCBI chr12:1,656,815...1,707,566
Ensembl chr12:1,656,918...1,709,585

G

nuclear receptor subfamily 4 group A member 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:48,208,354...48,232,857
Ensembl chr11:48,208,587...48,233,063

G

neuropilin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:32,474,787...32,632,746
Ensembl chr 9:32,474,309...32,633,101

G

neurotrophic receptor tyrosine kinase 1

severity

mRNA:increased expression:tumor:associated with increased tumor aggressiveness

NCBI chr20:6,987,903...7,027,381
Ensembl chr20:6,987,905...7,008,670

G

NUF2 component of NDC80 kinetochore complex

treatment

mRNA:increased expression:pancreas

PMID:25370920 PMID:26045769

RGD:11058437 RGD:28867232

NCBI chr25:65,462,608...65,493,242
Ensembl chr25:65,462,603...65,493,246

G

8-oxoguanine DNA glycosylase

disease_progression

DNA:polymorphism: :2657G>A (human)
DNA:polymorphism: :rs1052133 (human)

PMID:17230526 PMID:18559563

RGD:2317130 RGD:2317132

NCBI chr22:45,757,414...45,763,690

G

partner and localizer of BRCA2

susceptibility

ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 1 | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3

PMID:100849 PMID:9536098 PMID:16199547 PMID:17200668 PMID:17200671 More...

NCBI chr 5:21,322,952...21,358,363
Ensembl chr 5:21,322,975...21,358,198

G

palladin, cytoskeletal associated protein

susceptibility

ClinVar Annotator: match by term: PALLD-related condition | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2
ClinVar Annotator: match by term: PALLD-related condition | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1

PMID:10454945 PMID:11474289 PMID:17194196 PMID:17415588 PMID:24033266 More...

NCBI chr 7:114,758,017...115,173,240

G

platelet derived growth factor receptor alpha

mRNA:increased expression:pancreas

PMID:7665222 PMID:14695158

RGD:2324850 RGD:2324851

NCBI chr 7:14,243,291...14,307,373
Ensembl chr 7:14,241,070...14,307,422

G

pancreatic and duodenal homeobox 1

CTD Direct Evidence: marker/mechanism

PMID:19077462 PMID:25086665 PMID:26098869

NCBI chr 3:7,038,088...7,046,593
Ensembl chr 3:7,041,466...7,045,976

G

profilin 1

NCBI chr16:4,426,853...4,430,259
Ensembl chr16:4,426,962...4,429,713

G

plasminogen activator, urokinase

CTD Direct Evidence: marker/mechanism

NCBI chr 9:57,452,904...57,459,345
Ensembl chr 9:57,452,761...57,459,286

G

DNA polymerase beta

disease_progression

DNA:polymorphisms: :165A>G, 2133T>C (human)

NCBI chr 8:40,332,165...40,368,065
Ensembl chr 8:40,332,208...40,372,582

G

peroxisome proliferator activated receptor delta

disease_progression

NCBI chr17:36,695,546...36,779,554
Ensembl chr17:36,695,494...36,779,577

G

peroxisome proliferator activated receptor gamma

susceptibility

DNA:polymorphism: :p.P12A (human)
CTD Direct Evidence: marker/mechanism|therapeutic

PMID:11034103 PMID:11741176 PMID:19152448 PMID:19436234

RGD:2317460 RGD:2317462

NCBI chr22:48,262,743...48,407,415
Ensembl chr22:48,275,600...48,407,418

G

phosphatase and tensin homolog

CTD Direct Evidence: marker/mechanism

NCBI chr 9:81,308,058...81,412,386
Ensembl chr 9:81,309,099...81,409,146

G

prostaglandin-endoperoxide synthase 2

susceptibility

CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:pancreas
DNA:SNPs: :-1195A > G, -765G > C (human)
DNA:polymorphisms: :-1195A>A ,-765G>C (human)

PMID:10485483 PMID:10657949 PMID:15705899 PMID:16820089 PMID:19062735 More...

RGD:2317175 RGD:2317179 RGD:2317184 RGD:5135527

NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429

G

parathyroid hormone like hormone

CTD Direct Evidence: marker/mechanism

NCBI chr11:27,682,300...27,694,808
Ensembl chr11:27,682,338...27,694,898

G

RAB, member of RAS oncogene family like 3

susceptibility

ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 5 | ClinVar Annotator: match by term: RABL3-related condition

NCBI chr22:60,095,013...60,133,189
Ensembl chr22:60,095,066...60,136,337

G

RAD51 recombinase

protein:increased expression:pancreas (rat)

NCBI chr26:42,281,085...42,319,394
Ensembl chr26:42,279,608...42,318,169

G

RAD54 like

DNA:SNP:exon:rs1048771 (human)

NCBI chr20:86,510,616...86,542,426
Ensembl chr20:86,507,248...86,542,663

G

RAP1 GTPase activating protein

CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:pancreas (human)

PMID:16424023 PMID:22614916

NCBI chr20:110,967,457...111,040,940
Ensembl chr20:110,987,308...111,040,947

G

RB transcriptional corepressor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:26,220,783...26,393,671
Ensembl chr 3:26,220,803...26,394,546

G

RecQ like helicase

DNA:SNPs:introns
DNA:SNP:3'utr:rs13035 (human)

PMID:16540687 PMID:18422747 PMID:19768149

RGD:2317365 RGD:2317369 RGD:2317370

NCBI chr11:21,334,601...21,366,943
Ensembl chr11:21,331,584...21,366,979

G

RELA proto-oncogene, NF-kB subunit

NCBI chr 1:8,576,059...8,585,561
Ensembl chr 1:8,576,542...8,586,516

G

ret proto-oncogene

disease_progression

protein:increased expression:pancreas

NCBI chr 9:38,746,088...38,798,773
Ensembl chr 9:38,769,170...38,796,712

G

rhomboid domain containing 1

CTD Direct Evidence: therapeutic

NCBI chr10:112,882,789...113,018,889
Ensembl chr10:112,882,789...113,020,732

G

ribonucleotide reductase regulatory subunit M2

NCBI chr14:97,512,690...97,519,734
Ensembl chr14:97,512,832...97,521,932

G

RUNX family transcription factor 3

disease_progression

DNA:hypermethylation, loss of heterozygosity (human)

NCBI chr20:107,769,244...107,802,154
Ensembl chr20:107,736,683...107,802,307

G

retinoid X receptor alpha

NCBI chr12:3,704,129...3,814,707
Ensembl chr12:3,699,923...3,814,678

G

SEL1L adaptor subunit of SYVN1 ubiquitin ligase

NCBI chr24:58,812,553...58,877,173
Ensembl chr24:58,809,650...58,877,054

G

serpin family A member 1

disease_progression

NCBI chr24:72,158,521...72,171,139
Ensembl chr24:72,156,784...72,163,500

G

splicing factor 3b subunit 4

mRNA, protein:decreased expression:pancreas (human)

G

SIN3-HDAC complex associated factor

CTD Direct Evidence: marker/mechanism

NCBI chr11:30,755,143...30,797,383

G

solute carrier family 1 member 5

CTD Direct Evidence: marker/mechanism

NCBI chr 6:40,139,417...40,150,312

G

solute carrier family 29 member 1 (Augustine blood group)

CTD Direct Evidence: marker/mechanism

NCBI chr17:27,934,537...27,949,120
Ensembl chr17:27,931,945...27,949,006

G

solute carrier organic anion transporter family member 2B1

mRNA:decreased expression:pancreas (human)

NCBI chr 1:66,375,924...66,430,804
Ensembl chr 1:66,376,299...66,433,055

G

SMAD family member 2

mRNA:increased expression:pancreas (human)

NCBI chr18:33,017,138...33,105,320
Ensembl chr18:33,017,492...33,104,606

G

SMAD family member 3

DNA:mutations:exon

NCBI chr26:16,319,959...16,446,472
Ensembl chr26:16,320,933...16,446,527

G

SMAD family member 4

ClinVar Annotator: match by term: Cancer of the pancreas

NCBI chr18:29,894,157...29,951,445
Ensembl chr18:29,897,621...29,934,478

G

SMAD family member 7

mRNA:increased expression:pancreas (human)

NCBI chr18:31,993,543...32,024,088
Ensembl chr18:31,993,681...32,024,850

G

smoothened, frizzled class receptor

treatment

protein:increased expression:pancreas

PMID:19396459 PMID:19460966 PMID:22859707

RGD:150340554 RGD:2324910 RGD:2324978

NCBI chr21:97,788,955...97,814,549
Ensembl chr21:97,788,624...97,814,709

G

synuclein gamma

NCBI chr 9:44,907,840...44,914,750
Ensembl chr 9:44,907,728...44,912,510

G

SNW domain containing 1

susceptibility

DNA:snp:intron: T>A (human) (rs1477261)

NCBI chr24:54,976,597...55,020,051
Ensembl chr24:54,977,083...55,019,988

G

superoxide dismutase 1

protein:decreased expression:pancreas

NCBI chr 2:60,461,219...60,472,999

G

superoxide dismutase 2

disease_progression
susceptibility

CTD Direct Evidence: marker/mechanism
protein:decreased expression:pancreas
DNA:polymorphism:cds:p.A16V (human)

PMID:11328670 PMID:12499913 PMID:12700280 PMID:17895890 PMID:18205184

RGD:1581235 RGD:2317406 RGD:2317410

NCBI chr13:87,284,537...87,297,998
Ensembl chr13:87,280,686...87,297,974

G

serine peptidase inhibitor Kazal type 1

CTD Direct Evidence: marker/mechanism

NCBI chr23:50,365,686...50,373,300
Ensembl chr23:50,365,269...50,372,814

G

secreted phosphoprotein 1

NCBI chr 7:36,337,165...36,344,927
Ensembl chr 7:36,338,386...36,344,407

G

somatostatin

CTD Direct Evidence: therapeutic

NCBI chr15:81,946,287...81,947,775
Ensembl chr15:81,946,206...81,947,790

G

somatostatin receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr24:15,000,190...15,006,757
Ensembl chr24:15,003,116...15,004,291

G

somatostatin receptor 2

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:15259086 PMID:17625444 PMID:19917848

NCBI chr16:48,462,472...48,470,586
Ensembl chr16:48,464,342...48,465,451

G

somatostatin receptor 3

CTD Direct Evidence: marker/mechanism

NCBI chr19:19,908,562...19,916,787
Ensembl chr19:19,910,898...19,912,154

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

PMID:22348037 PMID:23845849

NCBI chr16:63,877,884...63,957,894
Ensembl chr16:63,922,862...63,957,984

G

serine/threonine kinase 11

NCBI chr 6:973,033...996,857
Ensembl chr 6:974,144...995,136

G

succinyl-CoA:glutarate-CoA transferase

CTD Direct Evidence: marker/mechanism

NCBI chr21:17,621,886...18,511,591
Ensembl chr21:18,151,535...18,511,310

G

synaptonemal complex protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:18,712,236...18,827,120
Ensembl chr20:18,712,587...18,823,277

G

transcription factor 7 like 2

DNA:mutations:exon

NCBI chr 9:105,828,834...106,047,810

G

telomerase reverse transcriptase

CTD Direct Evidence: marker/mechanism

PMID:25086665 PMID:26098869

NCBI chr 4:1,082,894...1,119,373
Ensembl chr 4:1,083,384...1,117,468

G

tissue factor pathway inhibitor 2

CTD Direct Evidence: marker/mechanism

NCBI chr21:55,134,921...55,139,862
Ensembl chr21:55,135,198...55,140,801

G

transforming growth factor alpha

mRNA, protein:increased expression:pancreas

PMID:1401070 PMID:17785207

RGD:2317468 RGD:2317473

NCBI chr14:36,545,641...36,654,213
Ensembl chr14:36,545,875...36,648,237

G

transforming growth factor beta 1

disease_progression

CTD Direct Evidence: marker/mechanism
protein:increased expression:serum

PMID:16933058 PMID:18787407 PMID:23992306

RGD:2325015 RGD:2325018

NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365

G

transforming growth factor beta receptor 2

disease_progression

protein:increased expresssion:pancreas
DNA:mutations:exon
DNA:deletion, frameshift mutations (human)
mRNA:increased expresssion:pancreas

PMID:9365135 PMID:9850059 PMID:11866987 PMID:18772397

RGD:2317499 RGD:2317501 RGD:2317502 RGD:5490966

NCBI chr15:75,112,903...75,200,263
Ensembl chr15:75,112,561...75,197,711

G

transglutaminase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:25,585,827...25,623,961
Ensembl chr 2:25,585,865...25,624,280

G

thrombospondin 1

disease_progression

DNA:hypermethylation (human)

PMID:10766168 PMID:16757110 PMID:20203415

RGD:2325021 RGD:2325023 RGD:2325028

NCBI chr26:43,410,693...43,427,816
Ensembl chr26:43,410,580...43,427,812

G

tumor necrosis factor

CTD Direct Evidence: therapeutic

G

TNF receptor superfamily member 10b

CTD Direct Evidence: therapeutic

NCBI chr 8:21,101,945...21,150,362
Ensembl chr 8:21,102,267...21,150,267

G

TNF superfamily member 10

CTD Direct Evidence: therapeutic

NCBI chr15:16,934,982...16,953,155
Ensembl chr15:16,934,962...16,954,860

G

tumor protein p53

CTD Direct Evidence: marker/mechanism
DNA:mutations:exon

PMID:18772397 PMID:23873029 PMID:26390243

NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223

G

tumor protein p53 binding protein 1

NCBI chr26:39,489,925...39,595,096
Ensembl chr26:39,508,600...39,594,927

G

tumor protein p63

CTD Direct Evidence: marker/mechanism

NCBI chr15:83,861,489...84,126,675

G

TSC complex subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:1,946,534...1,985,168
Ensembl chr 5:1,946,927...1,987,682

G

thymidine phosphorylase

CTD Direct Evidence: marker/mechanism

PMID:17443278 PMID:19671868

NCBI chr19:32,997,337...33,001,558
Ensembl chr19:32,997,304...33,001,215

G

thymidylate synthetase

CTD Direct Evidence: marker/mechanism

NCBI chr18:60,030,640...60,043,297
Ensembl chr18:60,030,658...60,041,856

G

uridine-cytidine kinase 2

protein:increased expression:pancreatic neoplasm (human)

NCBI chr25:62,974,515...63,059,436
Ensembl chr25:62,974,257...63,059,414

G

vascular cell adhesion molecule 1

NCBI chr20:32,616,425...32,635,903
Ensembl chr20:32,615,333...32,635,862

G

vascular endothelial growth factor B

CTD Direct Evidence: marker/mechanism

NCBI chr 1:9,997,820...10,001,518
Ensembl chr 1:9,997,665...10,001,429

G

von Hippel-Lindau tumor suppressor

associated with Hippel-Lindau Disease;DNA:missense mutation:exon:p.R238Q (human)
DNA:hypermethylation, deletion:promoter (human)

PMID:9488521 PMID:19690016

RGD:2325169 RGD:2325176

NCBI chr22:46,184,621...46,203,065
Ensembl chr22:46,184,756...46,204,428

G

Wnt family member 9A

DNA:mutations:exon

NCBI chr25:1,759,047...1,787,510
Ensembl chr25:1,781,826...1,788,663

G

WT1 transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr 1:32,750,300...32,801,832

G

XPC complex subunit, DNA damage recognition and repair factor

DNA:polymorphism:intron:AF076952 (human)

NCBI chr22:50,088,019...50,121,584
Ensembl chr22:50,085,353...50,121,542

G

exportin 1

exacerbates

protein:increased expression:pancreas (human)

NCBI chr14:45,428,279...45,487,965
Ensembl chr14:45,432,619...45,488,723

G

exportin 5

mRNA:decreased expression:pancreas (mouse)

NCBI chr17:28,585,317...28,637,045
Ensembl chr17:28,585,536...28,635,519

G

X-ray repair cross complementing 1

DNA:SNP:exon:rs1799782 (human)

NCBI chr 6:37,062,149...37,095,138
Ensembl chr 6:37,060,439...37,095,094

G

X-ray repair cross complementing 2

DNA:SNP:exon:rs3218536 (human)
DNA:polymorphism: :p.R188H (human)

PMID:16540687 PMID:17986315

RGD:2317365 RGD:2317507

NCBI chr21:120,795,188...120,827,737
Ensembl chr21:120,795,212...120,827,706

G

X-ray repair cross complementing 3

DNA:SNP:cd:rs861539 (human)

NCBI chr24:81,627,911...81,641,598
Ensembl chr24:81,630,099...81,641,218

G

zinc and ring finger 3

CTD Direct Evidence: marker/mechanism

PMID:25086665 PMID:26098869

NCBI chr19:11,754,263...11,928,158
Ensembl chr19:11,754,685...11,928,808

pancreatic carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activin A receptor type 1B

ClinVar Annotator: match by term: Carcinoma of pancreas

NCBI chr11:48,120,765...48,166,520
Ensembl chr11:48,145,003...48,166,813

G

ATM serine/threonine kinase

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:988733 PMID:1849795 PMID:3338800 PMID:8808599 PMID:9443866 More...

NCBI chr 1:99,653,208...99,786,889
Ensembl chr 1:99,653,139...99,791,520

G

BRCA1 DNA repair associated

ClinVar Annotator: match by term: Carcinoma of head of pancreas | ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:9150174 PMID:10667592 PMID:10667595 PMID:11802209 PMID:12566964 More...

NCBI chr16:63,162,827...63,243,928

G

BRCA2 DNA repair associated

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8665505 PMID:9150150 PMID:9361038 PMID:9536098 PMID:9585613 More...

NCBI chr 3:11,070,086...11,155,257
Ensembl chr 3:11,071,682...11,155,213

G

BRCA1 interacting DNA helicase 1

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:16116423 PMID:17033622 PMID:21964575 PMID:25330149 PMID:25741868 More...

NCBI chr16:32,909,226...33,085,551
Ensembl chr16:32,910,693...33,082,587

G

carbonyl reductase 4

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:17194196 PMID:25741868 PMID:28492532

NCBI chr 7:115,223,813...115,246,925
Ensembl chr 7:115,223,386...115,246,818

G

cyclin dependent kinase inhibitor 1A

NCBI chr17:35,445,668...35,454,334
Ensembl chr17:35,445,223...35,454,342

G

chromodomain helicase DNA binding protein 3

disease_progression

protein:increased expression:pancreas

NCBI chr16:7,274,634...7,300,831
Ensembl chr16:7,276,850...7,300,832

G

checkpoint kinase 2

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:9536098 PMID:10617473 PMID:11053450 PMID:11479205 PMID:11719428 More...

NCBI chr19:11,567,529...11,621,180
Ensembl chr19:11,567,528...11,604,792

G

chromosome unknown C11orf65 homolog

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:988733 PMID:1849795 PMID:3338800 PMID:8808599 PMID:9443866 More...

NCBI chr 1:99,804,191...99,879,834
Ensembl chr 1:99,804,218...99,827,182

G

ERCC excision repair 4, endonuclease catalytic subunit

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8797827 PMID:9579555 PMID:20221251 PMID:21228398 PMID:21612988 More...

NCBI chr 5:13,378,282...13,410,307
Ensembl chr 5:13,378,401...13,406,541

G

FA complementation group E

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:11001585 PMID:17924555 PMID:21279724 PMID:25741868 PMID:26822949 More...

NCBI chr17:36,659,266...36,671,274

G

FA complementation group G

ClinVar Annotator: match by term: Carcinoma of pancreas

NCBI chr12:45,537,817...45,544,038
Ensembl chr12:45,538,303...45,543,766

G

heterogeneous nuclear ribonucleoprotein A2/B1

severity

protein:increased expression:pancreas (rat)

NCBI chr21:32,167,126...32,178,031
Ensembl chr21:32,167,337...32,176,980

G

homeobox B13

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8756292 PMID:15964834 PMID:17138648 PMID:22236224 PMID:22714738 More...

NCBI chr16:69,137,561...69,141,615
Ensembl chr16:69,137,585...69,139,382

G

kinase insert domain receptor

treatment

NCBI chr 7:13,435,059...13,482,236
Ensembl chr 7:13,435,096...13,482,771

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:1875403 PMID:7773929 PMID:8439212 PMID:12110640 PMID:12720172 More...

NCBI chr11:24,963,396...25,010,747
Ensembl chr11:24,973,619...25,005,191

G

mechanistic target of rapamycin kinase

treatment

NCBI chr20:120,522,667...120,678,988
Ensembl chr20:120,525,737...120,679,020

G

MYC proto-oncogene, bHLH transcription factor

OMIM:260350

NCBI chr 8:122,282,989...122,288,392
Ensembl chr 8:122,282,630...122,288,384

G

nibrin

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:9590180 PMID:9590181 PMID:9620777 PMID:10398434 PMID:10799436 More...

NCBI chr 8:85,017,807...85,069,219
Ensembl chr 8:85,015,752...85,069,028

G

partner and localizer of BRCA2

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:17200668 PMID:17200671 PMID:17200672 PMID:20122277 PMID:20412113 More...

NCBI chr 5:21,322,952...21,358,363
Ensembl chr 5:21,322,975...21,358,198

G

palladin, cytoskeletal associated protein

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:17194196 PMID:25741868 PMID:28492532

NCBI chr 7:114,758,017...115,173,240

G

Raf-1 proto-oncogene, serine/threonine kinase

mRNA:increased expression:pancreas (rat)

NCBI chr22:48,560,270...48,643,537
Ensembl chr22:48,561,161...48,618,020

G

RB binding protein 8, endonuclease

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:9811458 PMID:28492532

NCBI chr18:57,501,070...57,617,301
Ensembl chr18:57,501,271...57,597,670

G

SMAD family member 4

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8653691 PMID:9582123 PMID:9811934 PMID:10398437 PMID:10764709 More...

NCBI chr18:29,894,157...29,951,445
Ensembl chr18:29,897,621...29,934,478

G

serine/threonine kinase 11

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:10362809 PMID:11430832 PMID:15188174 PMID:15800014 PMID:16287113 More...

NCBI chr 6:973,033...996,857
Ensembl chr 6:974,144...995,136

G

tumor protein p53

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:1565143 PMID:1565144 PMID:1581912 PMID:1591732 PMID:1631137 More...

NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223

G

TSC complex subunit 1

NCBI chr12:5,195,604...5,249,042
Ensembl chr12:5,195,675...5,244,157

pancreatic ductal adenocarcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

anterior gradient 2, protein disulphide isomerase family member

protein:increased expression:pancreas

NCBI chr21:41,311,250...41,324,806
Ensembl chr21:41,312,415...41,326,663

G

calreticulin

ameliorates

human cells in mouse model
human cells in a mouse model

PMID:29072694 PMID:33028359

RGD:150520160 RGD:150521706

NCBI chr 6:11,618,691...11,624,299
Ensembl chr 6:11,618,396...11,623,792

G

cyclin D1

severity

DNA:snp:exon:c.870G>A (human)
protein:increased expression:pancreas (human)

PMID:22939953 PMID:25470788

RGD:13462050 RGD:13462062

NCBI chr 1:4,909,616...4,922,272
Ensembl chr 1:4,907,353...4,922,357

G

CD59 molecule (CD59 blood group)

disease_progression

protein:increased expression:blood (human)

NCBI chr 1:31,547,876...31,571,720
Ensembl chr 1:31,547,937...31,570,835

G

cyclin dependent kinase 4

severity

protein:increased expression:pancreas, islet of Langerhans (human)

NCBI chr11:53,661,877...53,665,688
Ensembl chr11:53,659,336...53,664,861

G

E2F transcription factor 1

severity

DNA:amplification: : (human)
protein:increased expression:pancreatic ductal cell, nucleus (human)

PMID:12650514 PMID:17233815 PMID:27573434

RGD:13838735 RGD:13838738 RGD:13838739

NCBI chr 2:37,968,541...37,980,461
Ensembl chr 2:37,968,556...37,980,326

G

forkhead box M1

disease_progression

NCBI chr11:2,920,903...2,941,011
Ensembl chr11:2,920,663...2,940,823

G

far upstream element binding protein 1

mRNA:increased expression:pancreatic duct (human)

NCBI chr20:55,194,681...55,233,666
Ensembl chr20:55,194,743...55,230,277

G

GLI pathogenesis related 2

disease_progression

protein:decreased expression:blood (human)

NCBI chr12:44,395,343...44,422,118
Ensembl chr12:44,395,321...44,422,092

G

glutamic-oxaloacetic transaminase 1

treatment

human cells in a mouse model

NCBI chr 9:92,463,017...92,489,227
Ensembl chr 9:92,462,782...92,488,310

G

heat shock protein family A (Hsp70) member 8

disease_progression

protein:decreased expression:blood (human)

NCBI chr 1:114,447,348...114,452,693
Ensembl chr 1:114,446,544...114,451,562

G

inhibitor of nuclear factor kappa B kinase subunit beta

susceptibility

NCBI chr 8:40,267,532...40,325,282
Ensembl chr 8:40,268,079...40,326,381

G

Janus kinase 1

mRNA:decreased expression:pancreatic ductal cell (human)

NCBI chr20:68,122,134...68,253,361
Ensembl chr20:68,122,173...68,252,042

G

aflatoxin B1 aldehyde reductase member 2

protein:increased expression:pancreas

NCBI chr20:113,234,257...113,242,445

G

mitogen-activated protein kinase 8

severity
disease_progression

protein:increased phosphorylation:pancreas (mouse)

PMID:23237571 PMID:28837246

RGD:14348974 RGD:14348975

NCBI chr 9:43,356,603...43,489,066
Ensembl chr 9:43,356,308...43,393,425

G

placental growth factor

severity

associated with obesity

NCBI chr24:52,160,904...52,174,493
Ensembl chr24:52,161,787...52,173,989

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

mRNA, protein:increased expression:pancreas (human)

NCBI chr21:75,781,812...75,823,404
Ensembl chr21:75,784,648...75,825,496

G

phosphoinositide-3-kinase regulatory subunit 2

severity

human cells in a mouse model

NCBI chr 6:16,620,673...16,637,511
Ensembl chr 6:16,621,606...16,636,937

G

phospholipase D1

severity

protein:increased expression:pancreas (human)

NCBI chr15:17,667,079...17,871,452
Ensembl chr15:17,706,030...17,870,266

G

protein tyrosine phosphatase receptor type B

disease_progression

protein:decreased expression:blood (human)

NCBI chr11:66,095,445...66,222,402
Ensembl chr11:66,101,038...66,221,982

G

protein tyrosine phosphatase receptor type M

disease_progression

protein:decreased expression:blood (human)

NCBI chr18:66,564,562...67,398,541
Ensembl chr18:66,773,588...67,398,542

G

Rac family small GTPase 1

mRNA, protein:increased expression:pancreas (mouse)
mRNA:increased expression:pancreas (human)

PMID:21684285 PMID:23334332

RGD:14392806 RGD:14392816

NCBI chr28:15,583,609...15,610,753
Ensembl chr28:15,583,516...15,610,328

G

RAS like proto-oncogene A

mRNA:increased expression:pancreas (human)

NCBI chr21:18,826,569...18,911,379
Ensembl chr21:18,826,582...18,911,357

G

S100 calcium binding protein A8

disease_progression

protein:increased expression:blood (human)

NCBI chr20:10,363,142...10,364,293
Ensembl chr20:10,363,287...10,364,317

G

SMAD family member 2

severity

NCBI chr18:33,017,138...33,105,320
Ensembl chr18:33,017,492...33,104,606

G

transforming growth factor beta 1

ameliorates

protein:decreased expression:pancreas (human)

NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365

G

transforming growth factor beta 2

ameliorates

protein:decreased expression:pancreas (human)

NCBI chr25:11,163,651...11,259,868
Ensembl chr25:11,163,100...11,258,470

G

transforming growth factor beta 3

ameliorates

protein:decreased expression:pancreas (human)

NCBI chr24:53,203,593...53,227,483
Ensembl chr24:53,203,301...53,227,325

G

transforming growth factor beta receptor 1

ameliorates

human cell line in a mouse model

NCBI chr12:40,272,507...40,321,740
Ensembl chr12:40,276,916...40,297,372

G

vascular endothelial growth factor D

protein:increased expression:blood serum (human)

NCBI chr X:13,813,472...13,854,253
Ensembl chr X:13,813,403...13,854,057

pancreatic ductal carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin converting enzyme 2

protein:decreased expression:pancreas

NCBI chr X:14,032,231...14,094,163
Ensembl chr X:14,030,233...14,077,785

G

ADAM metallopeptidase domain 8

disease_progression

mRNA:increased expression:pancreas

NCBI chr26:53,114,184...53,129,650
Ensembl chr26:53,114,924...53,126,900

G

ADAM metallopeptidase domain 9

disease_progression

protein:altered localization:cytoplasm

NCBI chr 8:37,017,827...37,131,462
Ensembl chr 8:37,017,545...37,131,615

G

anterior gradient 2, protein disulphide isomerase family member

mRNA:increased expression:pancreas

NCBI chr21:41,311,250...41,324,806
Ensembl chr21:41,312,415...41,326,663

G

angiotensin II receptor type 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:41,957,826...42,002,776

G

albumin

disease_progression

NCBI chr 7:21,872,036...21,890,095
Ensembl chr 7:21,876,132...21,891,407

G

annexin A2

disease_progression

mRNA, protein:increased expression, altered localization:pancreas, plasma membrane

PMID:16450333 PMID:19260470

RGD:2317307 RGD:2325731

NCBI chr26:23,100,000...23,147,687
Ensembl chr26:23,099,992...23,145,457

G

annexin A5

protein:increased expression:pancreas

NCBI chr 7:68,940,365...68,970,324
Ensembl chr 7:68,940,304...68,970,811

G

arginase 2

CTD Direct Evidence: marker/mechanism

NCBI chr24:44,851,139...44,884,118
Ensembl chr24:44,851,175...44,883,853

G

BMI1 proto-oncogene, polycomb ring finger

protein:increased expression:pancreas
protein:increased expression:exocrine pancreas:

NCBI chr 9:22,095,592...22,104,894

G

calreticulin

protein:increased expression:pancreatic duct

NCBI chr 6:11,618,691...11,624,299
Ensembl chr 6:11,618,396...11,623,792

G

chromobox 7

disease_progression

protein:decreased expression:pancreas

NCBI chr19:21,776,618...21,798,525
Ensembl chr19:21,775,931...21,798,309

G

cholecystokinin A receptor

protein:decreased expression:pancreas
mRNA:increased expression:pancreatic duct

PMID:9239407 PMID:12851875

RGD:4110816 RGD:4110818

NCBI chr27:23,855,766...23,866,104
Ensembl chr27:23,856,705...23,865,367

G

cholecystokinin B receptor

protein:decreased expression:pancreas

NCBI chr 1:58,555,463...58,569,949
Ensembl chr 1:58,555,321...58,568,031

G

cyclin D1

severity

protein:increased expression:pancreas (human)

NCBI chr 1:4,909,616...4,922,272
Ensembl chr 1:4,907,353...4,922,357

G

CD40 molecule

treatment

protein:increased expression:dendritic cell

PMID:20976171 PMID:21436454 PMID:23983255

RGD:11522743 RGD:5490301 RGD:5490524

NCBI chr 2:17,753,713...17,765,134
Ensembl chr 2:17,753,394...17,764,566

G

cyclin dependent kinase 6

treatment

human cells in a mouse model

NCBI chr21:56,167,731...56,403,976
Ensembl chr21:56,170,450...56,393,808

G

cyclin dependent kinase inhibitor 1A

disease_progression

NCBI chr17:35,445,668...35,454,334
Ensembl chr17:35,445,223...35,454,342

G

claudin 4

NCBI chr28:9,242,054...9,244,972
Ensembl chr28:9,242,909...9,243,538

G

chromosome unknown C19orf33 homolog

CTD Direct Evidence: marker/mechanism

NCBI chr 6:32,947,469...32,948,721
Ensembl chr 6:32,947,820...32,949,288

G

C-X-C motif chemokine ligand 11

CTD Direct Evidence: marker/mechanism

NCBI chr 7:24,540,401...24,543,456
Ensembl chr 7:24,541,767...24,542,832

G

DNA methyltransferase 1

disease_progression

protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism

PMID:19424621 PMID:29844410

NCBI chr 6:9,199,006...9,263,890
Ensembl chr 6:9,199,003...9,263,607

G

DNA methyltransferase 3 beta

disease_progression

NCBI chr 2:37,128,635...37,176,033
Ensembl chr 2:37,146,538...37,174,570

G

deltex E3 ubiquitin ligase 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:108,299,691...108,343,271
Ensembl chr11:108,300,193...108,342,738

G

deltex E3 ubiquitin ligase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 1:14,354,752...14,390,630
Ensembl chr 1:14,358,001...14,390,239

G

epidermal growth factor

disease_progression

protein:increased expression: :

NCBI chr 7:57,810,110...57,911,361
Ensembl chr 7:57,811,728...57,911,516

G

Fas ligand

protein:increased expression:pancreas, liver

PMID:10547193 PMID:15375495

RGD:2317741 RGD:2317747

NCBI chr25:56,488,572...56,496,469
Ensembl chr25:56,489,417...56,496,251

G

fibroblast growth factor 2

disease_progression

PMID:12717266 PMID:18704599

RGD:2317756 RGD:2317758

NCBI chr 7:70,089,394...70,157,423

G

fascin actin-bundling protein 1

disease_progression

protein:increased expression:pancreas

NCBI chr28:16,127,033...16,142,285
Ensembl chr28:16,127,015...16,142,337

G

glycoprotein nmb

CTD Direct Evidence: marker/mechanism

NCBI chr21:35,037,197...35,066,143
Ensembl chr21:35,037,001...35,066,171

G

glutathione S-transferase pi 1

resistance

DNA:methylation: :
mRNA, protein:increased expression:pancreas

PMID:12488200 PMID:16537562 PMID:17265526

RGD:2317806 RGD:2317809 RGD:2317811

NCBI chr 1:6,676,897...6,679,936

G

histone deacetylase 1

disease_progression

protein:increased expression:pancreas

NCBI chr20:100,529,782...100,575,953
Ensembl chr20:100,530,369...100,558,556

G

HEAT repeat containing 1

treatment

NCBI chr25:73,684,845...73,743,594
Ensembl chr25:73,685,895...73,743,654

G

hes family bHLH transcription factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:88,220,093...88,222,563
Ensembl chr15:88,220,083...88,223,243

G

hes related family bHLH transcription factor with YRPW motif 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:75,225,081...75,228,941
Ensembl chr 8:75,224,769...75,228,896

G

hes related family bHLH transcription factor with YRPW motif 2

CTD Direct Evidence: marker/mechanism

NCBI chr13:47,965,808...47,977,435
Ensembl chr13:47,964,847...47,977,346

G

insulin like growth factor 1

NCBI chr11:97,624,498...97,708,730
Ensembl chr11:97,631,189...97,707,308

G

insulin like growth factor 1 receptor

protein:increased expression:pancreas

PMID:14506643 PMID:14627343

RGD:2317649 RGD:2317652

NCBI chr29:17,212,206...17,534,036
Ensembl chr29:17,459,404...17,526,930

G

interleukin 4

NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258

G

interleukin 4 receptor

protein:increased expression:pancreas

NCBI chr 5:25,019,638...25,069,732
Ensembl chr 5:25,046,701...25,070,015

G

insulin

Glucagon/insulin

NCBI chr 1:1,965,128...1,969,090

G

jagged canonical Notch ligand 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:27,484,699...27,521,108
Ensembl chr 2:27,484,760...27,522,504

G

jagged canonical Notch ligand 2

CTD Direct Evidence: marker/mechanism

NCBI chr24:83,050,412...83,081,982
Ensembl chr24:83,051,368...83,076,820

G

lysine demethylase 2B

severity

mRNA, protein:increased expression:pancreas (human)

NCBI chr11:116,805,541...116,957,236
Ensembl chr11:116,796,370...116,956,334

G

KIT ligand

CTD Direct Evidence: marker/mechanism

NCBI chr11:83,856,149...83,943,095
Ensembl chr11:83,856,157...83,943,083

G

KRAS proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism

PMID:25347530 PMID:30654191

NCBI chr11:24,963,396...25,010,747
Ensembl chr11:24,973,619...25,005,191

G

keratin 7

disease_progression

NCBI chr11:48,379,460...48,394,638
Ensembl chr11:48,379,465...48,394,643

G

L1 cell adhesion molecule

severity

protein:increased expression:pancreas (human)

NCBI chr X:128,285,128...128,309,173
Ensembl chr X:128,285,130...128,299,570

G

heat shock 70 kDa protein 1A

CTD Direct Evidence: marker/mechanism

NCBI chr17:40,191,695...40,194,459
Ensembl chr17:40,203,936...40,205,858

G

heat shock 70 kDa protein 1A

CTD Direct Evidence: marker/mechanism

NCBI chr17:40,203,647...40,206,028
Ensembl chr17:40,203,936...40,205,858

G

mucin-4

disease_progression

mRNA:increased expression:pancreas
protein:increased expression:pancreas

PMID:12657964 PMID:16049287

RGD:2324942 RGD:2324946

NCBI chr15:91,313,060...91,345,172

G

nucleoside diphosphate kinase A

protein:increased expression:pancreas (human)

NCBI chr16:42,186,039...42,195,608
Ensembl chr16:42,185,260...42,195,616

G

mitogen-activated protein kinase kinase kinase 7

CTD Direct Evidence: marker/mechanism

NCBI chr13:15,284,927...15,360,539
Ensembl chr13:15,284,923...15,360,832

G

mitogen-activated protein kinase 3

treatment

human cells in mouse model

NCBI chr 5:26,536,471...26,545,666
Ensembl chr 5:26,536,532...26,546,461

G

minichromosome maintenance complex component 7

mRNA, protein:increased expression:pancreatic duct

NCBI chr28:12,976,487...12,985,354
Ensembl chr28:12,977,013...12,985,898

G

MDM2 proto-oncogene

severity
onset

protein:increased expression:pancreas (human)
DNA:snp:promoter, intron:IVS1+309T>G (human)

PMID:15810085 PMID:19752772

RGD:2317414 RGD:2317416

NCBI chr11:64,434,203...64,465,490
Ensembl chr11:64,434,261...64,469,890

G

menin 1

NCBI chr 1:9,423,885...9,431,123
Ensembl chr 1:9,423,917...9,431,104

G

MET proto-oncogene, receptor tyrosine kinase

protein:increased expression:pancreatic duct (human)

NCBI chr21:85,370,574...85,486,405
Ensembl chr21:85,397,645...85,488,093

G

O-6-methylguanine-DNA methyltransferase

susceptibility

protein:increased activity, increased expression:ductal adenocarcinoma (human)
DNA:missense mutation:cds:p.L84F rs12917 (human)

PMID:9393761 PMID:16844323

RGD:2317648 RGD:2317664

NCBI chr 9:122,089,768...122,376,320

G

matrix metallopeptidase 2

severity

protein:increased expression:pancreas

NCBI chr 5:41,264,382...41,291,657
Ensembl chr 5:41,264,354...41,291,004

G

matrix metallopeptidase 9

protein:increased expression:blood
protein:increased expression:pancreas, serum

PMID:18706098 PMID:20332475

RGD:2325830 RGD:2325844

NCBI chr 2:17,867,267...17,874,757
Ensembl chr 2:17,867,177...17,874,712

G

mesothelin

disease_progression

protein:increased secretion:serum
DNA:hypomethylation:5'UTR
CTD Direct Evidence: marker/mechanism

PMID:12874021 PMID:14576474 PMID:19818733 PMID:21775916 PMID:25347530

RGD:2326055 RGD:2326065

NCBI chr 5:681,923...690,530
Ensembl chr 5:683,480...690,757

G

mucin 1, cell surface associated

disease_progression

protein:increased expression, altered localization:pancreas

PMID:14681945 PMID:18713982 PMID:19109152

RGD:2317983 RGD:2324616 RGD:2324633

NCBI chr20:8,641,701...8,646,739
Ensembl chr20:8,642,842...8,646,962

G

mucin 3A, cell surface associated

disease_progression

mRNA:increased expression:pancreas

G

mucin 5AC, oligomeric mucus/gel-forming

disease_progression

mRNA:increased expression:pancreas

PMID:7657125 PMID:10227724

RGD:2324907 RGD:2324986

NCBI chr 1:981,515...1,018,242

G

mucin 5B, oligomeric mucus/gel-forming

mRNA:increased expression:pancreas

NCBI chr 1:1,040,756...1,083,246
Ensembl chr 1:1,042,110...1,081,240

G

N-myc downstream regulated 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:127,668,012...127,727,918
Ensembl chr 8:127,667,981...127,719,011

G

NFE2 like bZIP transcription factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:62,789,647...62,825,651
Ensembl chr10:62,790,124...62,825,339

G

nitric oxide synthase 2

NCBI chr16:21,533,011...21,576,645
Ensembl chr16:21,533,484...21,574,257

G

notch receptor 1

CTD Direct Evidence: marker/mechanism

PMID:19028876 PMID:19208345 PMID:20484026

RGD:2325323 RGD:2325324

NCBI chr12:1,656,815...1,707,566
Ensembl chr12:1,656,918...1,709,585

G

notch receptor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 6:13,762,570...13,803,676
Ensembl chr 6:13,761,512...13,793,359

G

notch receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr17:39,806,864...39,837,101
Ensembl chr17:39,808,035...39,837,365

G

neurotrophic receptor tyrosine kinase 3

disease_progression

protein:increased expression:pancreas

PMID:10209957 PMID:11295066

RGD:2325660 RGD:2325663

NCBI chr29:6,441,824...6,831,029
Ensembl chr29:6,447,256...6,830,526

G

oncostatin M

CTD Direct Evidence: marker/mechanism

NCBI chr19:13,142,652...13,147,548
Ensembl chr19:13,144,442...13,147,494

G

palladin, cytoskeletal associated protein

protein:increased expression, alternative form:pancreas, fibroblast

NCBI chr 7:114,758,017...115,173,240

G

paired box 6

protein:increased expression:pancreatic duct (human)

NCBI chr 1:33,386,165...33,414,605
Ensembl chr 1:33,392,970...33,414,587

G

PMS1 homolog 1, mismatch repair system component

protein:increased expression:pancreatic duct

NCBI chr10:75,305,129...75,392,193
Ensembl chr10:75,311,887...75,392,590

G

peroxisome proliferator activated receptor gamma

disease_progression

NCBI chr22:48,262,743...48,407,415
Ensembl chr22:48,275,600...48,407,418

G

prostaglandin-endoperoxide synthase 2

NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429

G

RELA proto-oncogene, NF-kB subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 1:8,576,059...8,585,561
Ensembl chr 1:8,576,542...8,586,516

G

ring finger protein 2

protein:increased expression:pancreas

NCBI chr25:44,289,662...44,345,168
Ensembl chr25:44,291,576...44,345,236

G

retinoid X receptor alpha

severity

NCBI chr12:3,704,129...3,814,707
Ensembl chr12:3,699,923...3,814,678

G

serpin family A member 1

mRNA, protein:increased expression:pancreas

NCBI chr24:72,158,521...72,171,139
Ensembl chr24:72,156,784...72,163,500

G

solute carrier family 2 member 2

protein:increased expression:pancreatic duct

NCBI chr15:18,434,370...18,466,331
Ensembl chr15:18,434,916...18,467,352

G

SMAD family member 4

disease_progression

NCBI chr18:29,894,157...29,951,445
Ensembl chr18:29,897,621...29,934,478

G

smoothened, frizzled class receptor

NCBI chr21:97,788,955...97,814,549
Ensembl chr21:97,788,624...97,814,709

G

serine/threonine kinase 11

CTD Direct Evidence: marker/mechanism

NCBI chr 6:973,033...996,857
Ensembl chr 6:974,144...995,136

G

transforming growth factor beta 1

disease_progression

NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365

G

transforming growth factor beta receptor 2

disease_progression

mRNA:increased expresssion:pancreas

PMID:10547197 PMID:17114585

RGD:2317498 RGD:2317500

NCBI chr15:75,112,903...75,200,263
Ensembl chr15:75,112,561...75,197,711

G

thrombospondin 1

disease_progression

DNA:hypermethylation:promoter (human)

PMID:12429967 PMID:19065635

RGD:2325022 RGD:2325025

NCBI chr26:43,410,693...43,427,816
Ensembl chr26:43,410,580...43,427,812

G

transmembrane serine protease 3

NCBI chr 2:86,248,792...86,273,715
Ensembl chr 2:86,245,507...86,272,196

G

tumor protein p53

CTD Direct Evidence: marker/mechanism

NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223

G

TSC complex subunit 2

severity

NCBI chr 5:1,946,534...1,985,168
Ensembl chr 5:1,946,927...1,987,682

G

thymidine phosphorylase

disease_progression

NCBI chr19:32,997,337...33,001,558
Ensembl chr19:32,997,304...33,001,215

G

vascular endothelial growth factor A

CTD Direct Evidence: marker/mechanism

NCBI chr17:28,377,959...28,394,508

G

von Hippel-Lindau tumor suppressor

DNA:hypermethylation:promoter (human)

NCBI chr22:46,184,621...46,203,065
Ensembl chr22:46,184,756...46,204,428

G

YEATS domain containing 2

CTD Direct Evidence: marker/mechanism

NCBI chr15:5,607,788...5,716,245
Ensembl chr15:5,608,775...5,700,620

G

zinc finger ZZ-type containing 3

CTD Direct Evidence: marker/mechanism

NCBI chr20:55,493,316...55,613,263
Ensembl chr20:55,537,143...55,612,122

pancreatic endocrine carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BRCA2 DNA repair associated

ClinVar Annotator: match by term: Neuroendocrine tumor of pancreas

PMID:15145354 PMID:22762150 PMID:25741868 PMID:29446198

NCBI chr 3:11,070,086...11,155,257
Ensembl chr 3:11,071,682...11,155,213

G

cut like homeobox 1

exacerbates

protein:increased expression:pancreas (human)

NCBI chr28:10,901,529...11,370,834
Ensembl chr28:10,937,512...11,370,702

G

death domain associated protein

disease_progression

DNA:frameshift, frameshift mutations, nonsense mutation, missense mutations:CDS:multiple (human)

NCBI chr17:38,754,227...38,758,714
Ensembl chr17:38,754,280...38,759,071

G

O-6-methylguanine-DNA methyltransferase

DNA:hypermethylation:promoter (human)

NCBI chr 9:122,089,768...122,376,320

G

partner and localizer of BRCA2

ClinVar Annotator: match by term: Neuroendocrine tumor of pancreas

PMID:17200668 PMID:17200671 PMID:17200672 PMID:24136930 PMID:25099575 More...

NCBI chr 5:21,322,952...21,358,363
Ensembl chr 5:21,322,975...21,358,198

G

placental growth factor

treatment
disease_progression

human cells in a mouse model
protein:increased expression:serum (human)

PMID:23463017 PMID:26861455

RGD:14349029 RGD:14349030

NCBI chr24:52,160,904...52,174,493
Ensembl chr24:52,161,787...52,173,989

pancreatic intraductal papillary-mucinous neoplasm

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

DNA:missense mutation:cds:p.E17K (human)

NCBI chr24:82,704,087...82,730,711
Ensembl chr24:82,704,068...82,727,698

G

tumor protein p53

DNA:missense mutations: :multiple

NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223

G

vascular endothelial growth factor D

protein:increased expression:blood serum (human)

NCBI chr X:13,813,472...13,854,253
Ensembl chr X:13,813,403...13,854,057

Pancreatic Intraepithelial Neoplasia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

anterior gradient 2, protein disulphide isomerase family member

protein:increased expression:pancreas

NCBI chr21:41,311,250...41,324,806
Ensembl chr21:41,312,415...41,326,663

G

BMI1 proto-oncogene, polycomb ring finger

protein:increased expression:pancreatic acinar cell:
protein:increased expression:exocrine pancreas:

NCBI chr 9:22,095,592...22,104,894

G

chromobox 7

disease_progression

protein:decreased expression:pancreas

NCBI chr19:21,776,618...21,798,525
Ensembl chr19:21,775,931...21,798,309

G

cyclin D1

disease_progression

protein:increased expression:pancreas (human)

PMID:11751405 PMID:12882690

RGD:13462061 RGD:13464129

NCBI chr 1:4,909,616...4,922,272
Ensembl chr 1:4,907,353...4,922,357

G

DNA methyltransferase 1

protein:increased expression:pancreas

NCBI chr 6:9,199,006...9,263,890
Ensembl chr 6:9,199,003...9,263,607

G

histone deacetylase 1

protein:increased expression:pancreas

NCBI chr20:100,529,782...100,575,953
Ensembl chr20:100,530,369...100,558,556

G

inhibitor of nuclear factor kappa B kinase subunit beta

disease_progression
severity

PMID:22056382 PMID:22406536

RGD:13838740 RGD:13838742

NCBI chr 8:40,267,532...40,325,282
Ensembl chr 8:40,268,079...40,326,381

pancreatic mucinous cystadenoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

KRAS proto-oncogene, GTPase

severity

DNA:mutations:cds:

NCBI chr11:24,963,396...25,010,747
Ensembl chr11:24,973,619...25,005,191

pancreatic solid pseudopapillary carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin D1

severity

protein:increased expression:pancreas (human)

NCBI chr 1:4,909,616...4,922,272
Ensembl chr 1:4,907,353...4,922,357

vipoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

menin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:9,423,885...9,431,123
Ensembl chr 1:9,423,917...9,431,104

G

somatostatin

CTD Direct Evidence: therapeutic

NCBI chr15:81,946,287...81,947,775
Ensembl chr15:81,946,206...81,947,790

Term paths to the root

Path 1
Term	Annotations
disease	15417
disease of anatomical entity	15080
endocrine system disease	6102
pancreas disease	921
Pancreatic Neoplasms	398
Pancreatic Benign Neoplasm +	14
islet cell tumor +	29
pancreatic cancer +	395

paths to the root