Pancreatic Neoplasms - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Pancreatic Neoplasms	go back to main search page
Accession:	DOID:9003100	browse the term
Synonyms:	exact_synonym:	Pancreas Neoplasms; pancreas neoplasm; pancreatic neoplasm
	narrow_synonym:	Borderline Exocrine Pancreatic Neoplasm
	xref:	EFO:0003860; EFO:1000133; NCI:C34035

show annotations for term's descendants Sort by:
Rat (483) Mouse (506) Human (3151) Chinchilla (383) Bonobo (405) Dog (401) Squirrel (391) Pig (395) Green Monkey (398) Naked Mole-rat (380) All
Genes (400) Cell Lines (1)

Adult Pancreatic Cancer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism

NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444

duodenal gastrinoma

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

menin 1

associated with Neuroendocrine Tumors; DNA:loss of heterozygosity: :

NCBI chr18:52,346,747...52,352,884
Ensembl chr18:52,346,933...52,353,340

Familial Pancreatic Carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apolipoprotein A4

mRNA:increased expression:pancreas, carcinoma (human)

NCBI chr 5:16,751,588...16,754,215
Ensembl chr 5:16,751,799...16,754,837

G

ATM serine/threonine kinase

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:8755918 PMID:9443866 PMID:9463314 PMID:9887333 PMID:10330348 More...

NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207

G

BRCA1 associated RING domain 1

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:25085752 PMID:25741868 PMID:26315354 PMID:26467025 PMID:26787654 More...

NCBI chr37:21,946,770...22,024,672
Ensembl chr37:21,948,456...22,024,867

G

chromosome 5 C11orf65 homolog

ClinVar Annotator: match by term: Familial pancreatic carcinoma

NCBI chr 5:24,106,696...24,166,686
Ensembl chr 5:24,121,409...24,166,291

G

cyclin dependent kinase inhibitor 2A

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:11433531 PMID:11687599 PMID:12920094 PMID:22841127 PMID:25741868 More...

NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:2547513 PMID:3627975 PMID:7773929 PMID:8439212 PMID:12720172 More...

NCBI chr27:22,261,753...22,296,704
Ensembl chr27:22,257,941...22,293,369

G

SMAD family member 4

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:25741868 PMID:26467025 PMID:26900293 PMID:27611364 PMID:28283864 More...

NCBI chr 1:23,875,989...23,930,027
Ensembl chr 1:23,882,139...23,969,405

G

tumor protein p53

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:1565143 PMID:1565144 PMID:1631137 PMID:1683921 PMID:1978757 More...

NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109

gastrinoma

term browser

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Object Name

Qualifiers

Evidence

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Source

PubMed Reference(s)

RGD Reference(s)

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G

insulin like growth factor 1 receptor

mRNA and protein: increased expression::poor prognosis for high expression

NCBI chr 3:41,795,337...42,096,255
Ensembl chr 3:41,794,623...42,090,387

G

menin 1

CTD Direct Evidence: marker/mechanism
DNA:mutations: :

PMID:15944766 PMID:17961653

NCBI chr18:52,346,747...52,352,884
Ensembl chr18:52,346,933...52,353,340

G

MET proto-oncogene, receptor tyrosine kinase

severity

associated with Zollinger-Ellison Syndrome; mRNA:increased expression:tumor (human)

NCBI chr14:55,599,047...55,711,626
Ensembl chr14:55,598,337...55,724,027

G

O-6-methylguanine-DNA methyltransferase

DNA:hypomethylation:promoter (human)

NCBI chr28:38,204,611...38,427,482
Ensembl chr28:38,204,610...38,427,380

G

solute carrier family 2 member 2

mRNA:decreased expression:pancreatic islet

PMID:8421107 PMID:12114701

RGD:2324976 RGD:2324977

NCBI chr34:35,368,583...35,398,197
Ensembl chr34:35,370,192...35,400,409

Gastro-Enteropancreatic Neuroendocrine Tumor

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATM serine/threonine kinase

disease_progression

associated with Neoplasm Metastasis;mRNA, protein: decreased expression:gastrointestinal system, multiple (human)

NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207

G

ATRX chromatin remodeler

severity

NCBI chr X:59,772,067...60,107,016
Ensembl chr X:59,774,585...60,106,980

G

CD53 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 6:41,070,132...41,089,329
Ensembl chr 6:41,070,788...41,089,221

G

CD86 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr33:25,256,267...25,318,855
Ensembl chr33:25,256,267...25,318,087

G

class II major histocompatibility complex transactivator

CTD Direct Evidence: marker/mechanism

NCBI chr 6:31,774,486...31,837,025
Ensembl chr 6:31,774,609...31,836,820

G

C-X-C motif chemokine receptor 4

severity

protein:increased expression:colon (human)

NCBI chr19:38,874,650...38,877,740
Ensembl chr19:38,874,145...38,877,740

G

death domain associated protein

severity

NCBI chr12:2,755,960...2,760,687
Ensembl chr12:2,755,960...2,761,340

G

eomesodermin

CTD Direct Evidence: marker/mechanism

NCBI chr23:16,476,498...16,512,406
Ensembl chr23:16,506,032...16,511,527

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr 2:28,068,143...28,098,445
Ensembl chr 2:28,069,051...28,087,760

G

growth factor independent 1 transcriptional repressor

CTD Direct Evidence: marker/mechanism

NCBI chr 6:56,473,032...56,484,422
Ensembl chr 6:56,256,305...56,484,422

G

IKAROS family zinc finger 1

CTD Direct Evidence: marker/mechanism

NCBI chr18:1,661,851...1,750,987
Ensembl chr18:1,661,690...1,770,768

G

IKAROS family zinc finger 3

CTD Direct Evidence: marker/mechanism

NCBI chr 9:22,643,482...22,733,988
Ensembl chr 9:22,643,640...22,728,385

G

interleukin 10

CTD Direct Evidence: marker/mechanism

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

G

interleukin 2 receptor subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr10:27,370,797...27,388,775
Ensembl chr10:27,370,797...27,388,775

G

notch receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr17:56,854,825...57,020,157
Ensembl chr17:56,860,429...57,020,857

G

POU class 2 homeobox 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:112,165,908...112,252,712
Ensembl chr 1:112,220,511...112,321,672

G

protein tyrosine phosphatase receptor type C

CTD Direct Evidence: marker/mechanism

NCBI chr 7:4,155,876...4,282,151
Ensembl chr 7:4,137,728...4,282,124

G

RUNX family transcription factor 3

CTD Direct Evidence: marker/mechanism

G

serpin family A member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:63,388,498...63,400,377
Ensembl chr 8:63,376,945...63,398,435

Glucagonoma

term browser

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Object Name

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Evidence

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Source

PubMed Reference(s)

RGD Reference(s)

Position

G

betacellulin

protein:increased expression:pancreas

NCBI chr15:64,133,051...64,159,155
Ensembl chr15:64,135,920...64,158,970

G

menin 1

CTD Direct Evidence: marker/mechanism
DNA:deletion:exon

PMID:17961653 PMID:20138042

NCBI chr18:52,346,747...52,352,884
Ensembl chr18:52,346,933...52,353,340

G

solute carrier family 2 member 2

mRNA:decreased expression:pancreatic islet

PMID:8421107 PMID:12114701

RGD:2324976 RGD:2324977

NCBI chr34:35,368,583...35,398,197
Ensembl chr34:35,370,192...35,400,409

insulinoma

term browser

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PubMed Reference(s)

RGD Reference(s)

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G

adrenomedullin

protein:increased expression:pancreas, plasma

NCBI chr21:33,472,197...33,474,472
Ensembl chr21:33,471,623...33,474,495

G

B9 domain containing 2

mRNA, protein:decreased expression:pancreatic islet

NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885

G

betacellulin

protein:increased expression:pancreas

NCBI chr15:64,133,051...64,159,155
Ensembl chr15:64,135,920...64,158,970

G

CD40 molecule

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

cut like homeobox 1

exacerbates
disease_progression

protein:increased expression:pancreas (human)
mRNA:increased expression:pancreas (mouse)

NCBI chr 6:7,820,154...8,108,236
Ensembl chr 6:7,820,764...8,195,631

G

C-X-C motif chemokine ligand 12

protein:increased expression:pancreas

NCBI chr28:2,895,916...2,903,543

G

insulin

protein:altered localization:pancreas
protein:altered expression:blood

PMID:2565624 PMID:8175958

RGD:2317266 RGD:2317268

NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122

G

menin 1

disease_progression

DNA:deletion:exon
DNA:deletions:exons
CTD Direct Evidence: marker/mechanism

PMID:12941803 PMID:17961653 PMID:19208834 PMID:20138042

RGD:2317288 RGD:2317292 RGD:2317310

NCBI chr18:52,346,747...52,352,884
Ensembl chr18:52,346,933...52,353,340

G

neural cell adhesion molecule 1

protein:increased expression:pancreas

NCBI chr 5:19,895,587...20,192,334
Ensembl chr 5:19,895,613...20,191,995

G

ribosomal protein S15

NCBI chr20:57,406,544...57,407,015
Ensembl chr20:57,406,545...57,413,421

G

solute carrier family 2 member 2

mRNA:decreased expression:pancreatic islet
protein:increased expression:pancreatic B cell

PMID:8421107 PMID:12114701

RGD:2324976 RGD:2324977

NCBI chr34:35,368,583...35,398,197
Ensembl chr34:35,370,192...35,400,409

G

transforming growth factor alpha

protein:increased expression:pancreas

NCBI chr10:68,915,671...68,957,027

Islet Cell Adenomatosis

term browser

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Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

MAF bZIP transcription factor A

ClinVar Annotator: match by term: Islet cell adenomatosis

PMID:25741868 PMID:29339498 PMID:35406570

NCBI chr13:37,122,653...37,123,895
Ensembl chr13:37,122,731...37,123,771

islet cell tumor

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATRX chromatin remodeler

disease_progression

protein:decreased expression:pancreas:

NCBI chr X:59,772,067...60,107,016
Ensembl chr X:59,774,585...60,106,980

G

cyclin dependent kinase 4

protein:increased expression:pancreas, islet of Langerhans (human)

NCBI chr10:1,812,864...1,815,815
Ensembl chr10:1,812,886...1,815,789

G

death domain associated protein

disease_progression

NCBI chr12:2,755,960...2,760,687
Ensembl chr12:2,755,960...2,761,340

G

proprotein convertase subtilisin/kexin type 1

protein:increased expression:insulinoma (rat)

NCBI chr 3:13,233,342...13,276,921
Ensembl chr 3:13,233,594...13,274,094

Islet Cell Tumor Syndrome

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

farnesyltransferase, CAAX box, beta

ClinVar Annotator: match by term: Chromaffinoma

NCBI chr 8:39,364,067...39,429,129

G

MYC associated factor X

ClinVar Annotator: match by term: Chromaffinoma

PMID:21685915 PMID:22452945 PMID:23666964 PMID:25741868 PMID:26070438 More...

NCBI chr 8:39,441,216...39,465,703
Ensembl chr 8:39,380,686...39,465,959

G

myelin protein zero

ClinVar Annotator: match by term: Chromaffinoma

PMID:12807974 PMID:17468193 PMID:19454582 PMID:23342407 PMID:24033266 More...

NCBI chr38:21,205,339...21,210,439
Ensembl chr38:21,205,107...21,210,451

G

neurofibromin 1

ClinVar Annotator: match by term: Chromaffinoma

PMID:1568247 PMID:8264648 PMID:8499944 PMID:8499945 PMID:8669813 More...

NCBI chr 9:41,467,460...41,679,388
Ensembl chr 9:41,469,416...41,679,382

G

ret proto-oncogene

ClinVar Annotator: match by term: Chromaffinoma

PMID:2008030 PMID:2660074 PMID:2904651 PMID:3078962 PMID:7536460 More...

NCBI chr28:3,946,132...3,995,505
Ensembl chr28:3,947,232...3,994,210

G

succinate dehydrogenase complex assembly factor 2

ClinVar Annotator: match by term: Chromaffinoma

NCBI chr18:54,970,987...54,986,676
Ensembl chr18:54,971,658...54,987,394

G

succinate dehydrogenase complex iron sulfur subunit B

ClinVar Annotator: match by term: Chromaffinoma

PMID:490809 PMID:2308387 PMID:9509062 PMID:9536098 PMID:11404820 More...

NCBI chr 2:81,158,291...81,190,110
Ensembl chr 2:81,158,291...81,190,109

G

succinate dehydrogenase complex subunit C

ClinVar Annotator: match by term: Chromaffinoma

PMID:12807974 PMID:17468193 PMID:19454582 PMID:22517554 PMID:22703879 More...

NCBI chr38:21,162,850...21,200,429
Ensembl chr38:21,162,421...21,200,333

G

succinate dehydrogenase complex subunit D

ClinVar Annotator: match by term: Chromaffinoma

PMID:1945482 PMID:8981955 PMID:9536098 PMID:9683583 PMID:10323245 More...

NCBI chr 5:21,030,295...21,041,125

G

transmembrane protein 127

ClinVar Annotator: match by term: Chromaffinoma

PMID:9536098 PMID:16199547 PMID:16266984 PMID:17576681 PMID:20154675 More...

NCBI chr17:34,512,753...34,527,208
Ensembl chr17:34,512,792...34,523,692

G

von Hippel-Lindau tumor suppressor

ClinVar Annotator: match by term: Chromaffinoma

PMID:7563486 PMID:7987306 PMID:8707293 PMID:8772572 PMID:8956040 More...

NCBI chr20:8,206,616...8,211,347
Ensembl chr20:8,206,616...8,211,323

Melanoma-Pancreatic Cancer Syndrome

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin dependent kinase inhibitor 2A

ClinVar Annotator: match by term: Melanoma-pancreatic cancer syndrome

PMID:2319082 PMID:2813514 PMID:5001868 PMID:7566978 PMID:7632931 More...

NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379

non-functioning pancreatic endocrine tumor

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AT-rich interaction domain 1A

exacerbates

protein:decreased expression:endocrine pancreas (human)

NCBI chr 2:73,331,606...73,401,151
Ensembl chr 2:73,324,852...73,401,102

G

cyclin dependent kinase 4

associated with multiple endocrine neoplasia type 1;mRNA:increased expression:islet of Langerhans (human)

NCBI chr10:1,812,864...1,815,815
Ensembl chr10:1,812,886...1,815,789

G

cyclin dependent kinase 6

associated with multiple endocrine neoplasia type 1;mRNA:increased expression:islet of Langerhans (human)

NCBI chr14:18,178,352...18,413,869
Ensembl chr14:18,188,429...18,419,869

pancreatic acinar cell adenocarcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

B-Raf proto-oncogene, serine/threonine kinase

DNA:missense mutation, gene fusions:multiple (human)

NCBI chr16:8,222,909...8,318,179
Ensembl chr16:8,222,907...8,317,906

G

SRC proto-oncogene, non-receptor tyrosine kinase

disease_progression

NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077

pancreatic adenocarcinoma

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adhesion G protein-coupled receptor B1

mRNA:decreased expression:pancreas

NCBI chr13:36,627,791...36,649,013
Ensembl chr13:36,614,498...36,690,936

G

AKT serine/threonine kinase 3

severity

mRNA:increased expression:pancreas (human)

NCBI chr 7:34,633,064...34,931,112
Ensembl chr 7:34,636,124...34,931,112

G

baculoviral IAP repeat containing 2

exacerbates

mRNA:increased expression:pancreas (human)

NCBI chr 5:29,294,080...29,314,837
Ensembl chr 5:29,294,692...29,312,771

G

baculoviral IAP repeat containing 3

disease_progression

mRNA:increased expression:pancreas (human)

NCBI chr 5:29,324,893...29,343,322
Ensembl chr 5:29,325,331...29,337,240

G

baculoviral IAP repeat containing 5

exacerbates

mRNA:increased expression:pancreas (human)

NCBI chr 9:2,930,308...2,959,307

G

baculoviral IAP repeat containing 7

exacerbates

mRNA:increased expression:pancreas (human)

NCBI chr24:46,950,700...46,956,375
Ensembl chr24:46,952,474...46,955,495

G

carbonyl reductase 4

ClinVar Annotator: match by term: Pancreatic adenocarcinoma

PMID:9536098 PMID:17576681 PMID:25741868 PMID:28166811 PMID:28492532

NCBI chr25:19,475,562...19,618,144
Ensembl chr25:19,597,518...19,618,180

G

cyclin D1

severity

protein:increased expression:pancreas (human)

NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005

G

cyclin dependent kinase 4

treatment

human cells in a mouse model

NCBI chr10:1,812,864...1,815,815
Ensembl chr10:1,812,886...1,815,789

G

cyclin dependent kinase 6

treatment

human cells in a mouse model

NCBI chr14:18,178,352...18,413,869
Ensembl chr14:18,188,429...18,419,869

G

cyclin dependent kinase inhibitor 2A

DNA:missense mutations:cds:p.V126D, p.A148T (human)

NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379

G

C-X-C motif chemokine receptor 4

NCBI chr19:38,874,650...38,877,740
Ensembl chr19:38,874,145...38,877,740

G

E2F transcription factor 1

treatment

Human cells in a mouse model

NCBI chr24:22,895,149...22,904,689
Ensembl chr24:22,878,402...22,904,656

G

histidine rich glycoprotein

disease_progression

NCBI chr34:19,276,487...19,286,540
Ensembl chr34:19,276,549...19,286,537

G

Janus kinase 1

treatment

human cell line in a mouse model

NCBI chr 5:45,251,653...45,408,571
Ensembl chr 5:45,251,653...45,408,571

G

mitogen-activated protein kinase kinase 1

severity
treatment

protein:increased expression:pancreas (human)
human tissue in a mouse model

PMID:19513748 PMID:28849200

RGD:13838804 RGD:13838840

NCBI chr30:30,683,192...30,760,479
Ensembl chr30:30,683,107...30,760,479

G

mitogen-activated protein kinase 1

severity

mRNA:increased expression:pancreas (human)

NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998

G

mitogen-activated protein kinase 10

severity

DNA:SNP:intron: (rs2589506) (human)

NCBI chr32:9,584,437...9,889,118
Ensembl chr32:9,575,492...9,884,325

G

mitogen-activated protein kinase 8

exacerbates

protein:increased phosphorylation:pancreas (human)

NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401

G

mitogen-activated protein kinase 9

NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119

G

nuclear factor kappa B subunit 1

severity

mRNA:increased expression:pancreas (human)

NCBI chr32:23,948,598...24,040,704
Ensembl chr32:23,942,954...24,040,703

G

palladin, cytoskeletal associated protein

ClinVar Annotator: match by term: Pancreatic adenocarcinoma

PMID:9536098 PMID:10454945 PMID:11474289 PMID:17194196 PMID:17415588 More...

NCBI chr25:19,147,310...19,568,712
Ensembl chr25:19,146,898...19,553,679

G

plasminogen activator, tissue type

mRNA:increased expression:pancreas (human)

NCBI chr16:23,469,590...23,496,013

G

Rac family small GTPase 1

treatment

human cells in a mouse model

NCBI chr 6:11,726,259...11,758,532
Ensembl chr 6:11,655,494...11,757,216

G

Raf-1 proto-oncogene, serine/threonine kinase

treatment

human cells in a mouse model

NCBI chr20:5,892,839...5,972,672
Ensembl chr20:5,892,834...5,972,090

G

RAS like proto-oncogene B

treatment

human cells in a mouse model

NCBI chr19:29,820,006...29,868,345
Ensembl chr19:29,768,359...29,868,335

G

ralA binding protein 1

treatment

human cells in a mouse model

NCBI chr 7:75,461,220...75,511,860
Ensembl chr 7:75,461,222...75,510,229

G

SMAD family member 7

severity

human cell and construct in a mouse model

NCBI chr 7:79,706,485...79,734,673
Ensembl chr 7:79,706,705...79,734,749

G

signal transducer and activator of transcription 1

ameliorates

protein:increased expression:pancreas (human)

NCBI chr37:1,513,438...1,549,837
Ensembl chr37:1,507,219...1,550,178

G

vascular endothelial growth factor C

exacerbates

protein:increased expression:pancreas (human)

NCBI chr16:52,883,242...52,987,684
Ensembl chr16:52,883,139...52,987,563

pancreatic adenosquamous carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

transforming growth factor beta 2

ameliorates

human cells in a mouse model

NCBI chr38:13,430,832...13,511,655
Ensembl chr38:13,429,148...13,510,242

pancreatic cancer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1,4-N-acetylglucosaminyltransferase

mRNA:increased expression:blood, mononuclear cell

NCBI chr23:34,339,955...34,352,204
Ensembl chr23:34,341,628...34,348,068

G

ATP binding cassette subfamily C member 2

mRNA, protein:increased expression:pancreas

NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740

G

ATP binding cassette subfamily C member 3

severity

mRNA:increased expression:pancreas

NCBI chr 9:26,551,953...26,596,330
Ensembl chr 9:26,551,268...26,595,646

G

ATP binding cassette subfamily C member 5

mRNA:increased expression:pancreas

NCBI chr34:16,856,624...16,947,844
Ensembl chr34:16,856,633...16,946,422

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

CTD Direct Evidence: marker/mechanism

PMID:19648918 PMID:20103627 PMID:26098869

NCBI chr 9:49,746,749...49,758,317
Ensembl chr 9:49,748,693...49,758,479

G

angiotensin I converting enzyme

NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358

G

activin A receptor type 1

NCBI chr36:3,743,257...3,818,659
Ensembl chr36:3,744,163...3,818,652

G

activin A receptor type 1B

NCBI chr27:3,009,710...3,029,726
Ensembl chr27:2,994,857...3,042,396

G

activin A receptor type 2A

NCBI chr19:49,642,429...49,726,720
Ensembl chr19:49,641,219...49,723,420

G

ADAM metallopeptidase domain 15

mRNA:increased expression:pancreas, epithelial cell

NCBI chr 7:42,432,067...42,443,463
Ensembl chr 7:42,428,113...42,443,429

G

ADAM metallopeptidase domain 9

mRNA:increased expression:pancreas, epithelial cell

NCBI chr16:26,413,345...26,551,293
Ensembl chr16:26,414,583...26,551,122

G

adhesion G protein-coupled receptor E5

protein:increased expression:pancreas

NCBI chr20:48,204,738...48,220,249
Ensembl chr20:48,204,617...48,219,910

G

adrenomedullin

disease_progression

PMID:16841081 PMID:17363587

RGD:2325317 RGD:2325318

NCBI chr21:33,472,197...33,474,472
Ensembl chr21:33,471,623...33,474,495

G

advanced glycosylation end-product specific receptor

protein:decreased expression:serum

NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129

G

angiotensin II receptor type 2

mRNA:increased expression:pancreas

NCBI chr X:88,703,551...88,708,451
Ensembl chr X:88,705,765...88,706,853

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:increased expression:pancreas

PMID:12203118 PMID:25826687

NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444

G

AKT serine/threonine kinase 1

treatment
severity

human cells in a mouse model
protein:increased phosphorylation:pancreas (human)

PMID:11595724 PMID:20697673

RGD:13450953 RGD:13452388

NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193

G

albumin

disease_progression

PMID:18154768 PMID:20508721

RGD:2325675 RGD:2325678

NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709

G

aldehyde dehydrogenase 1 family member A1

protein:decreased expression:pancreas

NCBI chr 1:84,940,411...84,994,789
Ensembl chr 1:84,940,411...84,994,789

G

aldehyde dehydrogenase 2 family member

susceptibility

DNA:polymorphism (human)
DNA:polymorphism: :p.E504K (human)

PMID:15714130 PMID:19068087

RGD:2325313 RGD:2325694

NCBI chr26:9,319,109...9,361,021

G

arachidonate 12-lipoxygenase, 12R type

CTD Direct Evidence: marker/mechanism

NCBI chr 5:32,899,416...32,911,442
Ensembl chr 5:32,896,238...32,911,552

G

arachidonate 5-lipoxygenase

CTD Direct Evidence: marker/mechanism
protein:increased expression:pancreas

PMID:12163367 PMID:12481414 PMID:30258081

RGD:2317523 RGD:2317524

NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609

G

annexin A1

protein:increased expression:pancreas

PMID:17974280 PMID:19173988

RGD:2325722 RGD:2325723

NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011

G

annexin A10

CTD Direct Evidence: marker/mechanism

NCBI chr15:63,540,180...63,635,643
Ensembl chr15:63,540,054...63,635,656

G

apoptotic peptidase activating factor 1

mRNA:increased expression:pancreas

NCBI chr15:38,026,893...38,160,842
Ensembl chr15:38,028,132...38,114,987

G

APC regulator of WNT signaling pathway

ClinVar Annotator: match by term: Cancer of the pancreas

PMID:1316610 PMID:8381579 PMID:9101302 PMID:9824584 PMID:11852337 More...

NCBI chr 3:252,052...380,506
Ensembl chr 3:253,081...322,993

G

apolipoprotein A1

protein:increased expression:pancreas
protein:decreased expression:serum

PMID:17312459 PMID:17332923

RGD:2325757 RGD:2325758

NCBI chr 5:16,740,071...16,742,081
Ensembl chr 5:16,740,130...16,741,943

G

apolipoprotein E

protein:increased expression:pancreas (human)

NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440

G

actin related protein 2/3 complex subunit 1A

DNA:amplification (human)

NCBI chr 6:10,212,203...10,245,112
Ensembl chr 6:10,212,494...10,245,073

G

artemin

disease_progression

mRNA:increased expression:pancreas

PMID:19304517 PMID:20395845

RGD:2325815 RGD:2325817

G

ATM serine/threonine kinase

susceptibility

DNA:SNP:exon:rs1801516(human)
ClinVar Annotator: match by term: Pancreatic cancer

PMID:8698354 PMID:8845835 PMID:9497252 PMID:9536098 PMID:9792409 More...

NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207

G

ATR serine/threonine kinase

DNA:SNP: :340C>T (human)

NCBI chr23:38,131,956...38,223,888
Ensembl chr23:38,132,788...38,224,016

G

ATRX chromatin remodeler

CTD Direct Evidence: marker/mechanism

NCBI chr X:59,772,067...60,107,016
Ensembl chr X:59,774,585...60,106,980

G

AXL receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:112,699,679...112,727,434
Ensembl chr 1:112,700,365...112,726,960

G

beta-1,3-galactosyltransferase 5

mRNA:increased expression:pancreas

NCBI chr31:34,338,025...34,376,080
Ensembl chr31:34,369,298...34,373,204

G

B9 domain containing 2

disease_progression

protein:increased expression:serum
CTD Direct Evidence: marker/mechanism

PMID:16933058 PMID:18787407 PMID:23992306

RGD:2325015 RGD:2325018

NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885

G

BCL2 associated agonist of cell death

treatment

human cells in a mouse model

NCBI chr18:52,781,335...52,791,789
Ensembl chr18:52,781,921...52,791,405

G

BAG cochaperone 3

mRNA:increased expression:pancreas

NCBI chr28:29,792,612...29,815,466
Ensembl chr28:29,792,777...29,815,138

G

BAG cochaperone 4

mRNA:increased expression:pancreas

NCBI chr16:27,270,947...27,304,178
Ensembl chr16:27,273,848...27,303,786

G

BRCA1 associated deubiquitinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:37,355,499...37,364,298
Ensembl chr20:37,355,494...37,511,125

G

BCAR1 scaffold protein, Cas family member

CTD Direct Evidence: marker/mechanism

NCBI chr 5:75,463,906...75,499,557
Ensembl chr 5:75,463,926...75,512,476

G

BCL2 like 1

severity

human gene in a mouse model
CTD Direct Evidence: marker/mechanism

PMID:16904634 PMID:17941720

NCBI chr24:21,145,214...21,209,425
Ensembl chr24:21,145,215...21,196,355

G

BH3 interacting domain death agonist

NCBI chr27:45,344,304...45,355,735
Ensembl chr27:45,337,145...45,384,059

G

B-Raf proto-oncogene, serine/threonine kinase

disease_progression

human gene in a mouse model

PMID:18490924 PMID:22628411 PMID:22871572

RGD:13451537 RGD:13461863 RGD:13462040

NCBI chr16:8,222,909...8,318,179
Ensembl chr16:8,222,907...8,317,906

G

BRCA1 DNA repair associated

ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4

PMID:1157798 PMID:2173504 PMID:2316185 PMID:2504116 PMID:2618727 More...

NCBI chr 9:19,958,941...20,025,494
Ensembl chr 9:19,958,391...20,025,494

G

BRCA2 DNA repair associated

susceptibility

ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2
DNA:mutations: :
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2

ClinVar
RGD
OMIM

PMID:186727 PMID:251866 PMID:278235 PMID:1772447 PMID:2200631 More...

NCBI chr25:7,734,450...7,797,851
Ensembl chr25:7,734,453...7,797,815

G

basigin

CTD Direct Evidence: marker/mechanism

NCBI chr20:57,942,703...57,951,089
Ensembl chr20:57,943,276...57,951,061

G

BUB1 mitotic checkpoint serine/threonine kinase B

protein:altered localization:pancreas

NCBI chr30:7,361,982...7,410,162
Ensembl chr30:7,322,912...7,438,052

G

calcium binding protein 39

disease_progression

NCBI chr25:42,752,798...42,801,257
Ensembl chr25:42,703,332...42,799,279

G

calcyclin binding protein

disease_progression

mRNA, protein:increased expression:pancreas

NCBI chr 7:24,372,599...24,384,084
Ensembl chr 7:24,372,596...24,383,926

G

cyclase associated actin cytoskeleton regulatory protein 1

disease_progression

mRNA, protein:increased expression:pancreas

NCBI chr15:2,886,661...2,913,975

G

calpain 10

susceptibility

DNA:SNP:intron:rs3792267 (human)

NCBI chr25:50,555,402...50,566,132
Ensembl chr25:50,555,425...50,566,135

G

caspase 8

susceptibility

DNA:SNP: :rs1045485 (human)
DNA:deletion, insertion:promoter (human)

PMID:18483392 PMID:19843670

RGD:2315744 RGD:2317230

NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822

G

caspase 9

treatment
susceptibility

DNA:snp:promoter:g.-1263A>G (human)

PMID:19209030 PMID:20357690

RGD:13451540 RGD:13462046

NCBI chr 2:82,033,759...82,076,710
Ensembl chr 2:82,031,563...82,090,484

G

catalase

disease_progression

protein:decreased expression:pancreas

NCBI chr18:33,383,005...33,422,447
Ensembl chr18:33,383,005...33,422,447

G

carbonyl reductase 4

ClinVar Annotator: match by term: PALLD-related condition | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1

PMID:25741868 PMID:28492532

NCBI chr25:19,475,562...19,618,144
Ensembl chr25:19,597,518...19,618,180

G

cholecystokinin A receptor

mRNA:increased expression:pancreas

PMID:8222074 PMID:10457335

RGD:4110817 RGD:4110822

NCBI chr 3:84,010,700...84,019,066
Ensembl chr 3:84,010,205...84,021,293

G

cholecystokinin B receptor

disease_progression
susceptibility

mRNA:increased expression:pancreas

PMID:1458479 PMID:8222074 PMID:8302799 PMID:15688412

RGD:4110821 RGD:4110822 RGD:4110823 RGD:4110829

NCBI chr21:29,602,066...29,606,343
Ensembl chr21:29,604,150...29,605,725

G

C-C motif chemokine ligand 20

CTD Direct Evidence: marker/mechanism

PMID:10225458 PMID:30603057

NCBI chr25:40,506,385...40,509,903
Ensembl chr25:40,506,753...40,509,709

G

C-C motif chemokine ligand 5

NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852

G

cyclin D1

disease_progression
treatment

mRNA, protein:increased expression:pancreas (mouse)
human cells in a mouse model

PMID:11159909 PMID:17541034 PMID:22722256

RGD:13451541 RGD:13452385 RGD:13462059

NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005

G

cyclin G1

treatment

human cells in mouse model

NCBI chr 4:47,800,697...47,808,259
Ensembl chr 4:47,801,575...47,808,211

G

C-C motif chemokine receptor 4

protein:increased expression:pancreas

NCBI chr23:3,844,072...3,847,770
Ensembl chr23:3,844,173...3,845,255

G

C-C motif chemokine receptor 5

NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952

G

CD24 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr12:64,239,957...64,245,114

G

CD44 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr18:32,735,493...32,826,483
Ensembl chr18:32,737,907...32,827,107

G

cadherin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:80,757,508...80,834,878
Ensembl chr 5:80,757,508...80,834,878

G

cyclin dependent kinase 4

disease_progression
susceptibility

protein:increased expression:islet of Langerhans, nucleus (rat)
protein:increased expression:islet of Langerhans (human)
protein:increased expression:pancreas (mouse)

PMID:11159909 PMID:22477723 PMID:22761470 PMID:24531709

RGD:13452384 RGD:13452385 RGD:13452386 RGD:13452387

NCBI chr10:1,812,864...1,815,815
Ensembl chr10:1,812,886...1,815,789

G

cyclin dependent kinase inhibitor 2A

CTD Direct Evidence: marker/mechanism
DNA:mutations:exon

PMID:10627132 PMID:18772397 PMID:26098869

NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379

G

CASP8 and FADD like apoptosis regulator

CTD Direct Evidence: marker/mechanism

NCBI chr37:10,268,407...10,307,803
Ensembl chr37:10,268,582...10,345,095

G

CF transmembrane conductance regulator

onset
no_association

PMID:16227367 PMID:17072959

RGD:2317156 RGD:2317157

NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977

G

checkpoint kinase 1

disease_progression

DNA:SNP: :35G>A (human)

NCBI chr 5:8,878,511...8,910,626
Ensembl chr 5:8,879,147...8,907,669

G

claudin 4

PMID:19555390 PMID:19793693

RGD:2317580 RGD:2317583

NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145

G

CLPTM1 regulator of GABA type A receptor forward trafficking

CTD Direct Evidence: marker/mechanism

NCBI chr 1:110,471,164...110,500,229
Ensembl chr 1:110,471,559...110,500,175

G

cannabinoid receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:47,537,240...47,560,723
Ensembl chr12:47,509,583...47,560,983

G

cannabinoid receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:75,640,636...75,662,000
Ensembl chr 2:75,658,999...75,660,126

G

catenin beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr23:10,559,722...10,572,933
Ensembl chr23:10,559,718...10,572,927

G

C-X-C motif chemokine ligand 8

CTD Direct Evidence: marker/mechanism

NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354

G

cytochrome c, somatic

NCBI chr14:38,579,446...38,581,983
Ensembl chr14:38,579,446...38,581,983

G

cytochrome P450 family 17 subfamily A member 1

susceptibility

DNA:transition:5' utr:-34T>C rs743572 (human)

NCBI chr28:15,292,959...15,298,896
Ensembl chr28:15,293,106...15,298,852

G

death domain associated protein

CTD Direct Evidence: marker/mechanism

NCBI chr12:2,755,960...2,760,687
Ensembl chr12:2,755,960...2,761,340

G

discoidin domain receptor tyrosine kinase 1

treatment

NCBI chr12:653,800...671,190
Ensembl chr12:653,807...670,543

G

dihydropyrimidine dehydrogenase

disease_progression

CTD Direct Evidence: marker/mechanism
protein:increased expression:pancreas

PMID:17443278 PMID:18309485 PMID:19020767 PMID:20072795

RGD:2317629 RGD:2317630

NCBI chr 6:51,789,786...52,564,802
Ensembl chr 6:51,814,573...52,580,923

G

dual specificity tyrosine phosphorylation regulated kinase 1A

CTD Direct Evidence: marker/mechanism

NCBI chr31:32,564,970...32,655,232
Ensembl chr31:32,511,502...32,652,572

G

E2F transcription factor 1

treatment

NCBI chr24:22,895,149...22,904,689
Ensembl chr24:22,878,402...22,904,656

G

EGF containing fibulin extracellular matrix protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:56,632,801...56,694,872
Ensembl chr10:56,579,899...56,787,187

G

epidermal growth factor

disease_progression

protein:increased expression:pancreas

NCBI chr32:30,073,541...30,166,904
Ensembl chr32:30,073,950...30,166,295

G

epidermal growth factor receptor

CTD Direct Evidence: marker/mechanism

PMID:17452677 PMID:27720938

NCBI chr18:5,983,669...6,044,092
Ensembl chr18:5,982,770...6,042,631

G

eukaryotic translation initiation factor 4A3

protein:increased expression:serum (human)

NCBI chr 9:1,582,950...1,593,893
Ensembl chr 9:1,582,993...1,593,892

G

epithelial cell adhesion molecule

CTD Direct Evidence: marker/mechanism

NCBI chr10:49,446,165...49,498,690
Ensembl chr10:49,485,746...49,498,475

G

EPH receptor A3

NCBI chr33:770,234...1,092,063
Ensembl chr33:769,423...1,115,986

G

ERCC excision repair 1, endonuclease non-catalytic subunit

susceptibility

DNA:snp:3' utr:c.*197G>T (rs3212986) (human)

NCBI chr 1:110,130,353...110,146,660
Ensembl chr 1:110,130,481...110,146,602

G

ERCC excision repair 2, TFIIH core complex helicase subunit

treatment

DNA,protein:SNPs:exons:rs1799793,rs1052559
pancreatic adenocarcinoma;DNA:SNPs: :rs1799793,rs1052555(human)

PMID:16458430 PMID:18544627 PMID:21404106

RGD:11252206 RGD:2317223 RGD:2317228

NCBI chr 1:110,173,781...110,191,612
Ensembl chr 1:110,173,715...110,190,125

G

ERCC excision repair 4, endonuclease catalytic subunit

pancreatic adenocarcinoma;DNA:SNP: :rs1800067(human)

NCBI chr 6:29,193,192...29,226,935
Ensembl chr 6:29,196,421...29,226,887

G

ETAA1 activator of ATR kinase

CTD Direct Evidence: marker/mechanism

NCBI chr10:66,631,411...66,644,753
Ensembl chr10:66,631,544...66,643,728

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

protein:increased expression:pancreas

NCBI chr16:1,926,443...1,991,995
Ensembl chr16:1,925,956...1,991,838

G

FA complementation group A

DNA,Protein:polymorphisms:exons:c.377C>G, c.661A>G (human)

NCBI chr 5:63,778,149...63,838,869
Ensembl chr 5:63,778,212...63,838,823

G

FA complementation group C

DNA:nonsense mutation (human)

PMID:15695377 PMID:16243825

RGD:2317238 RGD:2317239

NCBI chr 1:71,388,931...71,678,019
Ensembl chr 1:71,487,601...71,678,506

G

FA complementation group G

NCBI chr11:51,652,939...51,659,766
Ensembl chr11:51,652,944...51,659,751

G

Fas ligand

severity
resistance

DNA:polymorphism:promoter:-844>>T (human)

PMID:11115536 PMID:12370548 PMID:18483392

RGD:2315744 RGD:2317744 RGD:2317745

NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224

G

fibroblast growth factor 13

CTD Direct Evidence: marker/mechanism

NCBI chr X:108,658,113...109,156,096
Ensembl chr X:108,658,941...109,156,594

G

fibroblast growth factor 2

severity

mRNA:increased expression:pancreas
protein:increased expression:bile

PMID:9293890 PMID:11478488 PMID:11562741 PMID:12670449

RGD:2317759 RGD:2317760 RGD:2317762 RGD:2317765

NCBI chr19:17,403,288...17,463,143
Ensembl chr19:16,994,661...17,463,151

G

fms related receptor tyrosine kinase 3 ligand

NCBI chr 1:107,015,222...107,025,181
Ensembl chr 1:107,015,223...107,024,708

G

forkhead box P1

CTD Direct Evidence: marker/mechanism

NCBI chr20:20,438,631...21,020,516
Ensembl chr20:20,788,433...21,016,397

G

fascin actin-bundling protein 1

severity

protein:increased expression:pancreas

NCBI chr 6:12,360,849...12,370,906
Ensembl chr 6:12,354,599...12,370,808

G

FXYD domain containing ion transport regulator 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:117,452,952...117,459,632
Ensembl chr 1:117,453,272...117,456,193

G

growth arrest and DNA damage inducible alpha

CTD Direct Evidence: therapeutic

NCBI chr 6:77,393,026...77,396,473
Ensembl chr 6:77,393,036...77,396,618

G

glial cell derived neurotrophic factor

severity

NCBI chr 4:70,966,694...70,991,860
Ensembl chr 4:70,971,432...70,989,714

G

GNAS complex locus

NCBI chr24:43,643,409...43,658,641
Ensembl chr24:43,643,405...43,658,657

G

golgi membrane protein 1

NCBI chr 1:73,609,224...73,654,280
Ensembl chr 1:73,546,172...73,652,370

G

glutathione S-transferase pi 1

susceptibility

DNA:SNP:cds:p.I105V (rs1695) (human)

PMID:19536452 PMID:19786118

RGD:2317804 RGD:2317805

NCBI chr18:49,905,161...49,908,182
Ensembl chr18:49,905,161...49,908,182

G

hepatocyte growth factor

protein:increased expression:serum

NCBI chr18:21,329,688...21,410,257
Ensembl chr18:21,332,817...21,410,263

G

hypoxia inducible factor 1 subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692

G

heparan sulfate-glucosamine 3-sulfotransferase 2

DNA:hypermethylation:promoter (human)

NCBI chr 6:22,814,966...22,905,633
Ensembl chr 6:22,815,738...22,906,537

G

heat shock protein family B (small) member 1

disease_progression

NCBI chr 6:7,487,164...7,488,576
Ensembl chr 6:7,487,250...7,488,576

G

intercellular adhesion molecule 1

mRNA, protein:increased expression:pancreas

NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914

G

interferon, alpha 5

CTD Direct Evidence: therapeutic

NCBI chr11:40,726,568...40,727,131
Ensembl chr11:40,726,568...40,727,131

G

interferon gamma

protein:increased expression:plasma

NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698

G

insulin like growth factor 1

susceptibility

DNA:polymorphism (human)

NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794

G

insulin like growth factor 1 receptor

PMID:14559833 PMID:19732452 PMID:19885860

RGD:2317640 RGD:2317642 RGD:2317651

NCBI chr 3:41,795,337...42,096,255
Ensembl chr 3:41,794,623...42,090,387

G

interleukin 10

susceptibility
disease_progression

DNA:polymorphism: :-1082G>A (human)
protein:increased expression:serum

PMID:17235586 PMID:19250218 PMID:30304975 PMID:30610790

RGD:14975253 RGD:14975257 RGD:2317653 RGD:2317655

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

G

interleukin 13

disease_progression

protein:increased expression:pancreas

PMID:12808442 PMID:18758789

RGD:2317669 RGD:2317670

NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388

G

interleukin 13 receptor subunit alpha 2

treatment

NCBI chr X:87,747,373...87,776,797
Ensembl chr X:87,747,373...87,776,798

G

interleukin 1 alpha

NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435

G

interleukin 1 beta

susceptibility

protein:increased expression:serum (human)
DNA:polymorphisms:promoter:-511C>T, -31T>C (human)

PMID:7787209 PMID:19251436

RGD:2311069 RGD:2317215

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

G

interleukin 2

treatment

NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394

G

interleukin 24

CTD Direct Evidence: therapeutic

NCBI chr 7:6,043,249...6,047,097
Ensembl chr 7:6,041,625...6,047,097

G

interleukin 3

protein:increased expression:serum

NCBI chr11:20,330,480...20,332,668
Ensembl chr11:20,330,480...20,332,668

G

interleukin 4

disease_progression

protein:increased expression:blood

PMID:10404069 PMID:12097255 PMID:19957810

RGD:2317261 RGD:2317265 RGD:2317267

NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534

G

interleukin 4 receptor

disease_progression

protein:increased expression:pancreas

NCBI chr 6:19,254,183...19,280,973
Ensembl chr 6:19,254,487...19,389,291

G

interleukin 6

disease_progression

PMID:30304975 PMID:30610790

RGD:14975253 RGD:14975257

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519

G

integrin linked kinase

DNA:mutations:exon

NCBI chr21:29,911,326...29,917,972
Ensembl chr21:29,911,364...29,917,974

G

inositol polyphosphate-4-phosphatase type II B

CTD Direct Evidence: marker/mechanism

NCBI chr19:826,711...1,192,340
Ensembl chr19:850,784...1,186,498

G

insulin

disease_progression
susceptibility

DNA:Polymorphism:promoter:-23 HphI (human)
associated with Diabetes Mellitus
associated with Diabetes Mellitus, Non-Insulin-Depend

PMID:19152242 PMID:19375425 PMID:19572116 PMID:19628082

RGD:2317245 RGD:2317247 RGD:2317250 RGD:2317253

NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122

G

integrin subunit alpha 11

DNA:mutations:exon

NCBI chr30:32,322,441...32,405,679
Ensembl chr30:32,323,687...32,405,661

G

integrin subunit alpha 4

DNA:mutations:exon

NCBI chr36:24,670,464...24,686,719
Ensembl chr36:24,653,408...24,729,057

G

integrin subunit alpha 9

DNA:mutations:exon

NCBI chr23:7,285,118...7,618,056
Ensembl chr23:7,281,378...7,613,899

G

kinase insert domain receptor

CTD Direct Evidence: therapeutic

PMID:12385004 PMID:19930156

NCBI chr13:47,442,861...47,484,574
Ensembl chr13:47,442,764...47,485,042

G

KLF transcription factor 5

CTD Direct Evidence: marker/mechanism

NCBI chr22:27,163,179...27,185,241
Ensembl chr22:27,162,397...27,200,871

G

KRAS proto-oncogene, GTPase

disease_progression

NCBI chr27:22,261,753...22,296,704
Ensembl chr27:22,257,941...22,293,369

G

L1 cell adhesion molecule

treatment

NCBI chr X:121,708,695...121,722,819
Ensembl chr X:121,708,894...121,733,365

G

lactate dehydrogenase A

CTD Direct Evidence: marker/mechanism

NCBI chr21:40,829,844...40,840,947

G

DNA ligase 3

resistance

DNA:SNP:intron:rs 2074522 (human)

NCBI chr 9:38,346,275...38,366,634
Ensembl chr 9:38,346,199...38,366,193

G

DNA ligase 4

susceptibility

associated with Diabetes Mellitus;DNA:polymorphism: :54C>T (human)

NCBI chr22:56,980,333...56,987,636
Ensembl chr22:56,980,622...56,983,357

G

mucin-6

protein:increased expression: :

NCBI chr18:45,359,412...45,376,678

G

cell division cycle 42

severity

mRNA, protein:increased expression:pancreas (human)

NCBI chr 2:77,153,276...77,169,947
Ensembl chr 2:77,153,095...77,199,211

G

mesothelin

CTD Direct Evidence: marker/mechanism
associated with Pancreatic Disease; protein:increased expression:pancreas

PMID:11751476 PMID:17019794 PMID:17785569 PMID:18281514 PMID:19843662

RGD:2326052 RGD:2326056 RGD:2326060 RGD:2326062

NCBI chr 6:39,827,985...39,834,945

G

lumican

disease_progression

DNA:SNP: :rs2268578 (human)

PMID:17671699 PMID:19843670

RGD:2317230 RGD:2317682

NCBI chr15:31,792,872...31,800,444
Ensembl chr15:31,793,233...31,800,912

G

lymphocyte antigen 6 family member E

CTD Direct Evidence: marker/mechanism

NCBI chr13:36,926,776...36,930,265
Ensembl chr13:36,925,980...36,974,979

G

mesencephalic astrocyte derived neurotrophic factor

no_association

DNA:polymorphisms: :multiple (human)
DNA:point mutations, deletions:cds:multiple (human)

PMID:9174057 PMID:17072959

RGD:2317157 RGD:2325804

NCBI chr20:38,196,427...38,200,114
Ensembl chr20:38,196,425...38,199,992

G

mitogen-activated protein kinase kinase 4

DNA:mutations:exon

NCBI chr 5:36,142,610...36,243,673
Ensembl chr 5:36,118,388...36,241,296

G

menin 1

associated with Neuroendocrine Tumors; protein:increased expression:multiple organs
CTD Direct Evidence: marker/mechanism

PMID:17278096 PMID:17961653 PMID:21252315

NCBI chr18:52,346,747...52,352,884
Ensembl chr18:52,346,933...52,353,340

G

MET proto-oncogene, receptor tyrosine kinase

severity

protein:increased expression:pancreas (rat)
mRNA:increased expression:pancreas (human)

PMID:9211490 PMID:15448002

RGD:2317235 RGD:2317613

NCBI chr14:55,599,047...55,711,626
Ensembl chr14:55,598,337...55,724,027

G

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

NCBI chr10:43,931,642...44,057,156
Ensembl chr10:43,931,673...44,080,347

G

O-6-methylguanine-DNA methyltransferase

protein:decreased expression:neuroendocrine tumor (human)

NCBI chr28:38,204,611...38,427,482
Ensembl chr28:38,204,610...38,427,380

G

microRNA mir-107

severity

NCBI chr28:4,484,653...4,484,710
Ensembl chr28:4,484,646...4,484,718

G

marker of proliferation Ki-67

disease_progression

protein:increased expression:pancreas

PMID:20137856 PMID:20350215

RGD:2317703 RGD:2317704

NCBI chr28:36,920,679...36,939,336
Ensembl chr28:36,913,023...36,939,486

G

matrix metallopeptidase 2

protein:increased activity:pancreatic juice
mRNA:increased expression:pancreas
CTD Direct Evidence: marker/mechanism

PMID:7635566 PMID:11961486 PMID:30603057

RGD:2325752 RGD:2325766

NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113

G

matrix metallopeptidase 9

disease_progression

mRNA:increased expression:pancreas
protein:increased expression:serum
CTD Direct Evidence: marker/mechanism

PMID:7635566 PMID:18030366 PMID:18445772 PMID:19629003 PMID:22952646

RGD:2325766 RGD:2325831 RGD:2325849 RGD:2325854

NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293

G

myeloperoxidase

resistance

DNA:polymorphism:promoter:-463G>A (human)

NCBI chr 9:32,927,483...32,938,007
Ensembl chr 9:32,927,483...32,937,820

G

methylthioadenosine phosphorylase

DNA, protein:deletion, decreased activity:pancreas:

NCBI chr11:41,148,389...41,200,635
Ensembl chr11:41,148,404...41,264,504

G

methylenetetrahydrofolate reductase

susceptibility

DNA:polymorphism: :677C>T (human)

NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818

G

mechanistic target of rapamycin kinase

NCBI chr 2:84,818,893...84,939,283
Ensembl chr 2:84,787,708...84,939,114

G

5-methyltetrahydrofolate-homocysteine methyltransferase

no_association
susceptibility

DNA:Polymorphism: :rs1805087 (human)

PMID:16737574 PMID:18843018

RGD:2317118 RGD:2317120

NCBI chr 4:3,219,851...3,328,000
Ensembl chr 4:3,215,090...3,328,115

G

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

susceptibility

DNA:polymorphism: :66A>G (human)
DNA:SNPs:intron, exon:rs162049, p.H595Y (rs10380) (human)

PMID:18515090 PMID:18843018

RGD:2317118 RGD:2325772

NCBI chr34:6,068,572...6,119,580
Ensembl chr34:6,070,046...6,098,312

G

mucin 1, cell surface associated

disease_progression

protein:increased secretion:bile
protein:increased expression:pancreas

PMID:14654947 PMID:18039393 PMID:18383873 PMID:18575732 PMID:19055478 More...

RGD:2317984 RGD:2317987 RGD:2324622 RGD:2324635 RGD:2324637 RGD:2324639

NCBI chr 7:42,338,939...42,344,690
Ensembl chr 7:42,340,375...42,344,690

G

mucin 16, cell surface associated

protein:increased expression:serum

NCBI chr20:51,790,036...51,876,801

G

mucin 4, cell surface associated

disease_progression

protein:increased expression:pancreas
mRNA:increased expression:pancreas
mRNA:increased expression:peripheral blood mononuclear cell

PMID:11751498 PMID:16274046 PMID:17406026 PMID:17595659 PMID:20303649

RGD:2324891 RGD:2324914 RGD:2324922 RGD:2324923 RGD:2324931

NCBI chr33:29,061,372...29,084,938
Ensembl chr33:29,063,096...29,111,802

G

mucin 5AC, oligomeric mucus/gel-forming

protein:increased expression:pancreas
protein:increased glycosylation:serum

PMID:14654947 PMID:19377061

RGD:2317984 RGD:2325129

NCBI chr18:45,471,232...45,498,961

G

MYC proto-oncogene, bHLH transcription factor

CTD Direct Evidence: marker/mechanism

PMID:22024988 PMID:25961927

NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309

G

nucleosome assembly protein 1 like 1

human gene in a mouse model

NCBI chr15:19,141,803...19,175,576
Ensembl chr15:19,143,284...19,175,581

G

neural cell adhesion molecule 1

severity
disease_progression

PMID:10374842 PMID:11249065

RGD:2326074 RGD:2326075

NCBI chr 5:19,895,587...20,192,334
Ensembl chr 5:19,895,613...20,191,995

G

NFKB inhibitor alpha

CTD Direct Evidence: therapeutic

NCBI chr 8:14,100,203...14,103,453
Ensembl chr 8:14,100,671...14,103,433

G

nerve growth factor receptor

severity

mRNA:increased expression:tumor:associated with longer overall survival

NCBI chr 9:25,598,468...25,621,021
Ensembl chr 9:25,601,074...25,623,274

G

nitric oxide synthase 2

disease_progression

protein:increased expression:pancreas

PMID:11196200 PMID:11687972 PMID:15165031

RGD:2325248 RGD:2325257 RGD:2325262

NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588

G

notch receptor 1

disease_progression

protein:increased expression:pancreas

NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277

G

nuclear receptor subfamily 4 group A member 1

CTD Direct Evidence: marker/mechanism

NCBI chr27:2,947,729...2,965,045
Ensembl chr27:2,891,053...2,955,655

G

nuclear receptor subfamily 5 group A member 2

CTD Direct Evidence: marker/mechanism

PMID:20101243 PMID:26098869

NCBI chr 7:2,925,915...3,062,118
Ensembl chr 7:2,927,326...3,062,348

G

neuropilin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:3,416,062...3,553,929
Ensembl chr 2:3,413,821...3,552,483

G

neurotrophic receptor tyrosine kinase 1

severity

mRNA:increased expression:tumor:associated with increased tumor aggressiveness

NCBI chr 7:41,140,931...41,159,326
Ensembl chr 7:41,140,879...41,159,288

G

NUF2 component of NDC80 kinetochore complex

treatment

mRNA:increased expression:pancreas

PMID:25370920 PMID:26045769

RGD:11058437 RGD:28867232

NCBI chr38:19,574,122...19,599,821
Ensembl chr38:19,574,125...19,599,064

G

8-oxoguanine DNA glycosylase

disease_progression

DNA:polymorphism: :rs1052133 (human)
DNA:polymorphism: :2657G>A (human)

PMID:17230526 PMID:18559563

RGD:2317130 RGD:2317132

NCBI chr20:8,486,150...8,491,448
Ensembl chr20:8,480,005...8,491,264

G

partner and localizer of BRCA2

susceptibility

ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 1 | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3
DNA:nonsense mutations:exon:172_175del, 3116del, 3256C>T (human)
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3

ClinVar
RGD
OMIM

PMID:100849 PMID:9536098 PMID:16199547 PMID:17200668 PMID:17200671 More...

NCBI chr 6:22,209,711...22,237,798
Ensembl chr 6:22,209,384...22,237,745

G

palladin, cytoskeletal associated protein

susceptibility

ClinVar Annotator: match by term: PALLD-related condition | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1

PMID:10454945 PMID:11474289 PMID:17194196 PMID:17415588 PMID:24033266 More...

NCBI chr25:19,147,310...19,568,712
Ensembl chr25:19,146,898...19,553,679

G

platelet derived growth factor receptor alpha

mRNA:increased expression:pancreas

PMID:7665222 PMID:14695158

RGD:2324850 RGD:2324851

NCBI chr13:46,729,722...46,775,828
Ensembl chr13:46,730,703...46,773,278

G

pancreatic and duodenal homeobox 1

CTD Direct Evidence: marker/mechanism

PMID:19077462 PMID:25086665 PMID:26098869

NCBI chr25:11,741,863...11,746,885
Ensembl chr25:11,741,863...11,746,885

G

profilin 1

NCBI chr 5:31,670,483...31,671,891
Ensembl chr 5:31,670,194...31,671,895

G

plasminogen activator, urokinase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:24,329,139...24,333,893
Ensembl chr 4:24,328,925...24,334,851

G

DNA polymerase beta

disease_progression

DNA:polymorphisms: :165A>G, 2133T>C (human)

NCBI chr16:23,306,359...23,335,352
Ensembl chr16:23,306,367...23,335,322

G

peroxisome proliferator activated receptor delta

disease_progression

NCBI chr12:4,492,867...4,579,340
Ensembl chr12:4,492,672...4,579,340

G

peroxisome proliferator activated receptor gamma

susceptibility

CTD Direct Evidence: marker/mechanism|therapeutic
DNA:polymorphism: :p.P12A (human)

PMID:11034103 PMID:11741176 PMID:19152448 PMID:19436234

RGD:2317460 RGD:2317462

NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981

G

patched 1

protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism

PMID:19077462 PMID:19396459

NCBI chr 1:71,246,750...71,309,036
Ensembl chr 1:71,238,195...71,305,662

G

phosphatase and tensin homolog

CTD Direct Evidence: marker/mechanism

NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176

G

prostaglandin-endoperoxide synthase 2

susceptibility

DNA:polymorphisms: :-1195A>A ,-765G>C (human)
CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:pancreas
DNA:SNPs: :-1195A > G, -765G > C (human)

PMID:10485483 PMID:10657949 PMID:15705899 PMID:16820089 PMID:19062735 More...

RGD:2317175 RGD:2317179 RGD:2317184 RGD:5135527

NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903

G

parathyroid hormone like hormone

CTD Direct Evidence: marker/mechanism

NCBI chr27:19,781,557...19,795,078
Ensembl chr27:19,781,557...19,795,078

G

RAB, member of RAS oncogene family like 3

susceptibility

ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 5 | ClinVar Annotator: match by term: RABL3-related condition

NCBI chr33:24,107,754...24,151,378
Ensembl chr33:24,066,306...24,151,354

G

RAD51 recombinase

protein:increased expression:pancreas (rat)

NCBI chr30:7,842,540...7,877,128
Ensembl chr30:7,842,540...7,877,606

G

RAD54 like

DNA:SNP:exon:rs1048771 (human)

NCBI chr15:14,111,168...14,139,819
Ensembl chr15:14,111,157...14,139,301

G

RAP1 GTPase activating protein

mRNA:decreased expression:pancreas (human)
CTD Direct Evidence: marker/mechanism

PMID:16424023 PMID:22614916

NCBI chr 2:77,509,592...77,554,620
Ensembl chr 2:77,527,914...77,544,205

G

RB transcriptional corepressor 1

CTD Direct Evidence: marker/mechanism

NCBI chr22:3,061,621...3,204,625
Ensembl chr22:3,063,239...3,257,726

G

RecQ like helicase

DNA:SNPs:introns
DNA:SNP:3'utr:rs13035 (human)

PMID:16540687 PMID:18422747 PMID:19768149

RGD:2317365 RGD:2317369 RGD:2317370

NCBI chr27:25,590,326...25,636,304
Ensembl chr27:25,590,831...25,636,685

G

RELA proto-oncogene, NF-kB subunit

NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875

G

ret proto-oncogene

disease_progression

protein:increased expression:pancreas

NCBI chr28:3,946,132...3,995,505
Ensembl chr28:3,947,232...3,994,210

G

rhomboid domain containing 1

CTD Direct Evidence: therapeutic

NCBI chr25:39,719,474...39,844,634
Ensembl chr25:39,719,872...39,842,289

G

ribonucleotide reductase regulatory subunit M2

NCBI chr17:7,106,515...7,113,868
Ensembl chr17:7,104,961...7,122,939

G

RUNX family transcription factor 3

disease_progression

DNA:hypermethylation, loss of heterozygosity (human)

G

retinoid X receptor alpha

NCBI chr 9:50,525,195...50,575,720
Ensembl chr 9:50,484,567...50,573,119

G

SEL1L adaptor subunit of ERAD E3 ubiquitin ligase

NCBI chr 8:53,767,799...53,824,391
Ensembl chr 8:53,771,252...53,824,298

G

serpin family A member 1

disease_progression

NCBI chr 8:63,388,498...63,400,377
Ensembl chr 8:63,376,945...63,398,435

G

splicing factor 3b subunit 4

mRNA, protein:decreased expression:pancreas (human)

NCBI chr17:59,208,989...59,214,643
Ensembl chr17:59,208,990...59,213,991

G

SIN3-HDAC complex associated factor

CTD Direct Evidence: marker/mechanism

NCBI chr27:17,421,065...17,456,628
Ensembl chr27:17,429,052...17,455,144

G

solute carrier family 1 member 5

CTD Direct Evidence: marker/mechanism

NCBI chr 1:109,150,205...109,161,375
Ensembl chr 1:109,150,205...109,161,141

G

solute carrier family 29 member 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:12,632,233...12,644,669
Ensembl chr12:12,634,194...12,644,667

G

solute carrier organic anion transporter family member 2B1

mRNA:decreased expression:pancreas (human)

NCBI chr21:23,347,593...23,393,480
Ensembl chr21:23,346,070...23,473,831

G

SMAD family member 2

mRNA:increased expression:pancreas (human)

NCBI chr 7:43,696,883...43,778,063
Ensembl chr 7:43,700,445...43,769,983

G

SMAD family member 3

DNA:mutations:exon

NCBI chr30:31,246,313...31,360,098
Ensembl chr30:31,245,657...31,363,337

G

SMAD family member 4

ClinVar Annotator: match by term: Cancer of the pancreas

NCBI chr 1:23,875,989...23,930,027
Ensembl chr 1:23,882,139...23,969,405

G

SMAD family member 7

mRNA:increased expression:pancreas (human)

NCBI chr 7:79,706,485...79,734,673
Ensembl chr 7:79,706,705...79,734,749

G

smoothened, frizzled class receptor

treatment

protein:increased expression:pancreas

PMID:19396459 PMID:19460966 PMID:22859707

RGD:150340554 RGD:2324910 RGD:2324978

NCBI chr14:7,518,871...7,527,703
Ensembl chr14:7,518,856...7,528,033

G

synuclein gamma

NCBI chr 4:34,604,867...34,608,851
Ensembl chr 4:34,605,091...34,608,842

G

SNW domain containing 1

susceptibility

DNA:snp:intron: T>A (human) (rs1477261)

NCBI chr 8:50,478,924...50,512,360
Ensembl chr 8:50,479,338...50,512,243

G

superoxide dismutase 1

protein:decreased expression:pancreas

NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815

G

superoxide dismutase 2

disease_progression
susceptibility

CTD Direct Evidence: marker/mechanism
protein:decreased expression:pancreas
DNA:polymorphism:cds:p.A16V (human)

PMID:11328670 PMID:12499913 PMID:12700280 PMID:17895890 PMID:18205184

RGD:1581235 RGD:2317406 RGD:2317410

NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706

G

serine peptidase inhibitor Kazal type 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:42,112,015...42,120,738
Ensembl chr 2:42,112,016...42,120,706

G

secreted phosphoprotein 1

NCBI chr32:11,354,070...11,362,325
Ensembl chr32:11,353,953...11,362,069

G

somatostatin

CTD Direct Evidence: therapeutic

NCBI chr34:20,063,091...20,064,520
Ensembl chr34:20,063,090...20,064,557

G

somatostatin receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:16,571,069...16,575,730

G

somatostatin receptor 2

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:15259086 PMID:17625444 PMID:19917848

NCBI chr 9:6,989,488...7,004,851
Ensembl chr 9:6,996,874...7,000,778

G

somatostatin receptor 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:27,324,067...27,332,570
Ensembl chr10:27,329,174...27,330,451

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

PMID:22348037 PMID:23845849

NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672

G

serine/threonine kinase 11

NCBI chr20:57,558,966...57,579,163
Ensembl chr20:57,559,424...57,579,118

G

succinyl-CoA:glutarate-CoA transferase

CTD Direct Evidence: marker/mechanism

NCBI chr18:9,051,920...9,766,342
Ensembl chr18:9,030,745...9,766,277

G

synaptonemal complex protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:52,538,909...52,681,495
Ensembl chr17:52,539,615...52,648,133

G

transcription factor 7 like 2

DNA:mutations:exon

NCBI chr28:23,966,079...24,162,775
Ensembl chr28:23,966,073...24,163,737

G

telomerase reverse transcriptase

CTD Direct Evidence: marker/mechanism

PMID:25086665 PMID:26098869

NCBI chr34:11,288,622...11,307,790
Ensembl chr34:11,288,622...11,307,951

G

tissue factor pathway inhibitor 2

CTD Direct Evidence: marker/mechanism

NCBI chr14:19,399,259...19,403,890
Ensembl chr14:19,399,720...19,403,708

G

transforming growth factor alpha

mRNA, protein:increased expression:pancreas

PMID:1401070 PMID:17785207

RGD:2317468 RGD:2317473

NCBI chr10:68,915,671...68,957,027

G

transforming growth factor beta receptor 2

disease_progression

protein:increased expresssion:pancreas
DNA:mutations:exon
mRNA:increased expresssion:pancreas
DNA:deletion, frameshift mutations (human)

PMID:9365135 PMID:9850059 PMID:11866987 PMID:18772397

RGD:2317499 RGD:2317501 RGD:2317502 RGD:5490966

NCBI chr23:13,886,869...13,946,480
Ensembl chr23:13,889,000...13,977,636

G

transglutaminase 2

CTD Direct Evidence: marker/mechanism

NCBI chr24:26,631,339...26,662,723
Ensembl chr24:26,628,009...26,663,840

G

thrombospondin 1

disease_progression

DNA:hypermethylation (human)

PMID:10766168 PMID:16757110 PMID:20203415

RGD:2325021 RGD:2325023 RGD:2325028

NCBI chr30:6,770,212...6,786,875
Ensembl chr30:6,769,470...6,784,915

G

tumor necrosis factor

CTD Direct Evidence: therapeutic

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

G

TNF superfamily member 10

CTD Direct Evidence: therapeutic

NCBI chr34:36,719,249...36,734,989
Ensembl chr34:36,670,849...36,735,060

G

tumor protein p53

DNA:mutations:exon
CTD Direct Evidence: marker/mechanism

PMID:18772397 PMID:23873029 PMID:26390243

NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109

G

tumor protein p53 binding protein 1

NCBI chr30:10,263,650...10,362,646
Ensembl chr30:10,263,650...10,336,134

G

tumor protein p63

CTD Direct Evidence: marker/mechanism

NCBI chr34:21,766,861...21,985,095
Ensembl chr34:21,766,496...21,983,046

G

TSC complex subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:38,865,509...38,898,977
Ensembl chr 6:38,865,507...38,898,960

G

thymidylate synthetase

CTD Direct Evidence: marker/mechanism

NCBI chr 7:67,487,927...67,497,747
Ensembl chr 7:67,487,927...67,497,747

G

uridine-cytidine kinase 2

protein:increased expression:pancreatic neoplasm (human)

NCBI chr38:17,475,789...17,555,926
Ensembl chr38:17,479,558...17,579,675

G

vascular cell adhesion molecule 1

NCBI chr 6:49,341,669...49,359,841
Ensembl chr 6:49,342,151...49,359,933

G

vascular endothelial growth factor B

CTD Direct Evidence: marker/mechanism

NCBI chr18:52,821,348...52,824,649
Ensembl chr18:52,821,365...52,824,655

G

von Hippel-Lindau tumor suppressor

DNA:hypermethylation, deletion:promoter (human)
associated with Hippel-Lindau Disease;DNA:missense mutation:exon:p.R238Q (human)

PMID:9488521 PMID:19690016

RGD:2325169 RGD:2325176

NCBI chr20:8,206,616...8,211,347
Ensembl chr20:8,206,616...8,211,323

G

Wnt family member 9A

DNA:mutations:exon

NCBI chr14:946,843...959,289
Ensembl chr14:953,244...959,295

G

WT1 transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr18:35,099,660...35,148,767
Ensembl chr18:35,103,934...35,148,000

G

XPC complex subunit, DNA damage recognition and repair factor

DNA:polymorphism:intron:AF076952 (human)

NCBI chr20:4,299,644...4,328,826
Ensembl chr20:4,300,386...4,328,768

G

exportin 1

exacerbates

protein:increased expression:pancreas (human)

NCBI chr10:61,541,647...61,588,397
Ensembl chr10:61,542,211...61,585,054

G

exportin 5

mRNA:decreased expression:pancreas (mouse)

NCBI chr12:11,983,071...12,034,441
Ensembl chr12:11,983,646...12,034,688

G

X-ray repair cross complementing 1

DNA:SNP:exon:rs1799782 (human)

NCBI chr 1:111,548,719...111,571,816
Ensembl chr 1:111,548,719...111,571,816

G

X-ray repair cross complementing 2

DNA:polymorphism: :p.R188H (human)
DNA:SNP:exon:rs3218536 (human)

PMID:16540687 PMID:17986315

RGD:2317365 RGD:2317507

NCBI chr16:16,402,821...16,429,095
Ensembl chr16:16,402,933...16,429,037

G

X-ray repair cross complementing 3

DNA:SNP:cd:rs861539 (human)

NCBI chr 8:71,441,732...71,452,922
Ensembl chr 8:71,442,429...71,449,408

G

zinc and ring finger 3

CTD Direct Evidence: marker/mechanism

PMID:25086665 PMID:26098869

NCBI chr26:22,315,947...22,397,568
Ensembl chr26:22,334,998...22,394,228

pancreatic carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activin A receptor type 1B

ClinVar Annotator: match by term: Carcinoma of pancreas

NCBI chr27:3,009,710...3,029,726
Ensembl chr27:2,994,857...3,042,396

G

ATM serine/threonine kinase

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:988733 PMID:1849795 PMID:3338800 PMID:8808599 PMID:9443866 More...

NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207

G

BRCA1 DNA repair associated

ClinVar Annotator: match by term: Carcinoma of head of pancreas | ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:9150174 PMID:10667592 PMID:10667595 PMID:11802209 PMID:12566964 More...

NCBI chr 9:19,958,941...20,025,494
Ensembl chr 9:19,958,391...20,025,494

G

BRCA2 DNA repair associated

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8665505 PMID:9150150 PMID:9361038 PMID:9536098 PMID:9585613 More...

NCBI chr25:7,734,450...7,797,851
Ensembl chr25:7,734,453...7,797,815

G

BRCA1 interacting helicase 1

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:16116423 PMID:17033622 PMID:21964575 PMID:25330149 PMID:25741868 More...

NCBI chr 9:34,804,285...34,984,640
Ensembl chr 9:34,806,535...34,983,788

G

chromosome 5 C11orf65 homolog

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:988733 PMID:1849795 PMID:3338800 PMID:8808599 PMID:9443866 More...

NCBI chr 5:24,106,696...24,166,686
Ensembl chr 5:24,121,409...24,166,291

G

carbonyl reductase 4

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:17194196 PMID:25741868 PMID:28166811 PMID:28492532

NCBI chr25:19,475,562...19,618,144
Ensembl chr25:19,597,518...19,618,180

G

cyclin dependent kinase inhibitor 1A

NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281

G

cyclin dependent kinase inhibitor 2A

susceptibility

DNA:insertion:cds:p.R112_L113insR (human)

NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379

G

chromodomain helicase DNA binding protein 3

disease_progression

protein:increased expression:pancreas

NCBI chr 5:32,747,341...32,768,114
Ensembl chr 5:32,747,397...32,766,965

G

checkpoint kinase 2

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:9536098 PMID:10617473 PMID:11053450 PMID:11479205 PMID:11719428 More...

NCBI chr26:22,052,256...22,145,675
Ensembl chr26:21,427,961...22,240,624

G

ERCC excision repair 4, endonuclease catalytic subunit

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8797827 PMID:9579555 PMID:20221251 PMID:21228398 PMID:21612988 More...

NCBI chr 6:29,193,192...29,226,935
Ensembl chr 6:29,196,421...29,226,887

G

FA complementation group E

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:11001585 PMID:17924555 PMID:21279724 PMID:25741868 PMID:26822949 More...

NCBI chr12:4,587,053...4,600,946
Ensembl chr12:4,587,041...4,600,405

G

FA complementation group G

ClinVar Annotator: match by term: Carcinoma of pancreas

NCBI chr11:51,652,939...51,659,766
Ensembl chr11:51,652,944...51,659,751

G

heterogeneous nuclear ribonucleoprotein A2/B1

severity

protein:increased expression:pancreas (rat)

NCBI chr14:39,498,805...39,509,034
Ensembl chr14:39,500,897...39,508,952

G

homeobox B13

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8756292 PMID:15964834 PMID:17138648 PMID:22236224 PMID:22714738 More...

NCBI chr 9:24,958,020...24,961,353
Ensembl chr 9:24,959,183...24,961,588

G

kinase insert domain receptor

treatment

NCBI chr13:47,442,861...47,484,574
Ensembl chr13:47,442,764...47,485,042

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:7773929 PMID:8439212 PMID:12110640 PMID:12720172 PMID:14982869 More...

NCBI chr27:22,261,753...22,296,704
Ensembl chr27:22,257,941...22,293,369

G

microRNA mir-155

miRNA:increased expression:serum

NCBI chr31:21,078,768...21,078,828
Ensembl chr31:21,078,758...21,078,833

G

mechanistic target of rapamycin kinase

treatment

NCBI chr 2:84,818,893...84,939,283
Ensembl chr 2:84,787,708...84,939,114

G

MYC proto-oncogene, bHLH transcription factor

OMIM:260350

NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309

G

nibrin

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:9590180 PMID:9590181 PMID:9620777 PMID:10398434 PMID:10799436 More...

NCBI chr29:35,416,093...35,477,569
Ensembl chr29:35,416,093...35,477,563

G

partner and localizer of BRCA2

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:17200668 PMID:17200671 PMID:17200672 PMID:20122277 PMID:20412113 More...

NCBI chr 6:22,209,711...22,237,798
Ensembl chr 6:22,209,384...22,237,745

G

palladin, cytoskeletal associated protein

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:17194196 PMID:25741868 PMID:28166811 PMID:28492532

NCBI chr25:19,147,310...19,568,712
Ensembl chr25:19,146,898...19,553,679

G

DNA polymerase delta 1, catalytic subunit

ClinVar Annotator: match by term: Carcinoma of pancreas

NCBI chr 1:106,302,583...106,331,353
Ensembl chr 1:106,302,574...106,331,385

G

Raf-1 proto-oncogene, serine/threonine kinase

mRNA:increased expression:pancreas (rat)

NCBI chr20:5,892,839...5,972,672
Ensembl chr20:5,892,834...5,972,090

G

RB binding protein 8, endonuclease

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:9811458 PMID:28492532

NCBI chr 7:65,218,288...65,319,696
Ensembl chr 7:65,218,297...65,297,099

G

SMAD family member 4

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8653691 PMID:9582123 PMID:9811934 PMID:10398437 PMID:10764709 More...

NCBI chr 1:23,875,989...23,930,027
Ensembl chr 1:23,882,139...23,969,405

G

serine/threonine kinase 11

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:10362809 PMID:11430832 PMID:15188174 PMID:15800014 PMID:16287113 More...

NCBI chr20:57,558,966...57,579,163
Ensembl chr20:57,559,424...57,579,118

G

tumor protein p53

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:1565143 PMID:1565144 PMID:1581912 PMID:1591732 PMID:1631137 More...

NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109

G

TSC complex subunit 1

NCBI chr 9:51,409,307...51,459,546
Ensembl chr 9:51,425,937...51,454,677

pancreatic ductal adenocarcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

anterior gradient 2, protein disulphide isomerase family member

protein:increased expression:pancreas

NCBI chr14:31,303,784...31,316,752
Ensembl chr14:31,305,567...31,316,686

G

aldo-keto reductase family 7 member A2

protein:increased expression:pancreas

NCBI chr 2:79,334,179...79,343,880
Ensembl chr 2:79,334,205...79,343,007

G

B9 domain containing 2

ameliorates

protein:decreased expression:pancreas (human)

NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885

G

calreticulin

ameliorates

human cells in mouse model
human cells in a mouse model

PMID:29072694 PMID:33028359

RGD:150520160 RGD:150521706

NCBI chr20:49,251,390...49,255,291
Ensembl chr20:49,251,777...49,255,245

G

cyclin D1

severity

protein:increased expression:pancreas (human)
DNA:snp:exon:c.870G>A (human)

PMID:22939953 PMID:25470788

RGD:13462050 RGD:13462062

NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005

G

CD59 molecule

disease_progression

protein:increased expression:blood (human)

NCBI chr18:33,977,433...33,999,145
Ensembl chr18:33,977,480...33,998,329

G

cyclin dependent kinase 4

severity

protein:increased expression:pancreas, islet of Langerhans (human)

NCBI chr10:1,812,864...1,815,815
Ensembl chr10:1,812,886...1,815,789

G

E2F transcription factor 1

severity

protein:increased expression:pancreatic ductal cell, nucleus (human)
DNA:amplification: : (human)

PMID:12650514 PMID:17233815 PMID:27573434

RGD:13838735 RGD:13838738 RGD:13838739

NCBI chr24:22,895,149...22,904,689
Ensembl chr24:22,878,402...22,904,656

G

forkhead box M1

disease_progression

NCBI chr27:41,894,605...41,905,656
Ensembl chr27:41,894,672...41,905,663

G

far upstream element binding protein 1

mRNA:increased expression:pancreatic duct (human)

NCBI chr 6:68,923,215...68,963,766

G

GLI pathogenesis related 2

disease_progression

protein:decreased expression:blood (human)

NCBI chr11:52,622,460...52,634,602
Ensembl chr11:52,615,039...52,681,270

G

glutamic-oxaloacetic transaminase 1

treatment

human cells in a mouse model

NCBI chr28:12,352,658...12,377,960
Ensembl chr28:12,352,659...12,414,579

G

heat shock protein family A (Hsp70) member 8

disease_progression

protein:decreased expression:blood (human)

NCBI chr 5:11,292,219...11,296,851
Ensembl chr 5:11,292,262...11,296,797

G

inhibitor of nuclear factor kappa B kinase subunit beta

susceptibility

NCBI chr16:23,359,551...23,419,114
Ensembl chr16:23,359,813...23,419,075

G

Janus kinase 1

mRNA:decreased expression:pancreatic ductal cell (human)

NCBI chr 5:45,251,653...45,408,571
Ensembl chr 5:45,251,653...45,408,571

G

mitogen-activated protein kinase 8

disease_progression
severity

protein:increased phosphorylation:pancreas (mouse)

PMID:23237571 PMID:28837246

RGD:14348974 RGD:14348975

NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401

G

microRNA mir-155

disease_progression

NCBI chr31:21,078,768...21,078,828
Ensembl chr31:21,078,758...21,078,833

G

microRNA mir-494

ameliorates
disease_progression

NCBI chr 8:69,261,385...69,261,465
Ensembl chr 8:69,261,385...69,261,465

G

placental growth factor

severity

associated with obesity

NCBI chr 8:48,059,554...48,110,534
Ensembl chr 8:48,059,552...48,075,170

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

mRNA, protein:increased expression:pancreas (human)

NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141

G

phosphoinositide-3-kinase regulatory subunit 2

severity

human cells in a mouse model

NCBI chr20:44,826,037...44,838,449
Ensembl chr20:44,826,339...44,836,558

G

phospholipase D1

severity

protein:increased expression:pancreas (human)

NCBI chr34:35,917,759...36,080,383
Ensembl chr34:35,921,058...36,121,631

G

protein tyrosine phosphatase receptor type B

disease_progression

protein:decreased expression:blood (human)

NCBI chr10:12,267,891...12,384,522
Ensembl chr10:12,241,716...12,384,435

G

protein tyrosine phosphatase receptor type M

disease_progression

protein:decreased expression:blood (human)

NCBI chr 7:74,005,682...74,597,498
Ensembl chr 7:73,815,186...74,609,116

G

Rac family small GTPase 1

mRNA:increased expression:pancreas (human)
mRNA, protein:increased expression:pancreas (mouse)

PMID:21684285 PMID:23334332

RGD:14392806 RGD:14392816

NCBI chr 6:11,726,259...11,758,532
Ensembl chr 6:11,655,494...11,757,216

G

RAS like proto-oncogene A

mRNA:increased expression:pancreas (human)

NCBI chr18:10,022,490...10,047,583
Ensembl chr18:10,024,311...10,039,183

G

S100 calcium binding protein A8

disease_progression

protein:increased expression:blood (human)

NCBI chr 7:43,540,667...43,541,604
Ensembl chr 7:43,501,989...43,541,604

G

SMAD family member 2

severity

NCBI chr 7:43,696,883...43,778,063
Ensembl chr 7:43,700,445...43,769,983

G

transforming growth factor beta 2

ameliorates

protein:decreased expression:pancreas (human)

NCBI chr38:13,430,832...13,511,655
Ensembl chr38:13,429,148...13,510,242

G

transforming growth factor beta 3

ameliorates

protein:decreased expression:pancreas (human)

NCBI chr 8:48,920,874...48,946,037
Ensembl chr 8:48,923,423...48,945,816

G

transforming growth factor beta receptor 1

ameliorates

human cell line in a mouse model

NCBI chr11:56,191,383...56,223,042
Ensembl chr11:56,161,772...56,218,594

G

vascular endothelial growth factor D

protein:increased expression:blood serum (human)

NCBI chr X:11,590,097...11,627,199
Ensembl chr X:11,590,089...11,626,486

G

vanin 1

disease_progression

protein:increased expression:blood (human)

NCBI chr 1:25,678,039...25,704,579
Ensembl chr 1:25,678,042...25,696,807

pancreatic ductal carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

mRNA, protein:increased expression:pancreas

NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358

G

angiotensin converting enzyme 2

protein:decreased expression:pancreas

NCBI chr X:11,798,839...11,839,591
Ensembl chr X:11,798,839...11,900,594

G

ADAM metallopeptidase domain 8

disease_progression

mRNA:increased expression:pancreas

NCBI chr28:40,853,665...40,865,604
Ensembl chr28:40,855,509...40,863,747

G

ADAM metallopeptidase domain 9

disease_progression

protein:altered localization:cytoplasm

NCBI chr16:26,413,345...26,551,293
Ensembl chr16:26,414,583...26,551,122

G

anterior gradient 2, protein disulphide isomerase family member

mRNA:increased expression:pancreas

NCBI chr14:31,303,784...31,316,752
Ensembl chr14:31,305,567...31,316,686

G

angiotensin II receptor type 1

CTD Direct Evidence: marker/mechanism

NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238

G

albumin

disease_progression

NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709

G

annexin A2

disease_progression

mRNA, protein:increased expression, altered localization:pancreas, plasma membrane

PMID:16450333 PMID:19260470

RGD:2317307 RGD:2325731

NCBI chr30:25,176,845...25,210,244
Ensembl chr30:25,115,842...25,218,281

G

annexin A5

protein:increased expression:pancreas

NCBI chr19:18,419,936...18,450,088
Ensembl chr19:18,407,587...18,570,378

G

apolipoprotein C1

NCBI chr 1:110,520,177...110,522,563
Ensembl chr 1:110,520,198...110,631,412

G

arginase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:41,588,051...41,619,406
Ensembl chr 8:41,588,150...41,619,402

G

B9 domain containing 2

disease_progression

NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885

G

BMI1 proto-oncogene, polycomb ring finger

protein:increased expression:pancreas
protein:increased expression:exocrine pancreas:

NCBI chr 2:10,818,232...10,828,473
Ensembl chr 2:10,818,232...10,833,613

G

chromosome 1 C19orf33 homolog

CTD Direct Evidence: marker/mechanism

NCBI chr 1:114,689,909...114,693,980

G

calreticulin

protein:increased expression:pancreatic duct

NCBI chr20:49,251,390...49,255,291
Ensembl chr20:49,251,777...49,255,245

G

chromobox 7

disease_progression

protein:decreased expression:pancreas

NCBI chr10:25,876,022...25,896,284
Ensembl chr10:25,876,016...25,893,501

G

cholecystokinin A receptor

mRNA:increased expression:pancreatic duct
protein:decreased expression:pancreas

PMID:9239407 PMID:12851875

RGD:4110816 RGD:4110818

NCBI chr 3:84,010,700...84,019,066
Ensembl chr 3:84,010,205...84,021,293

G

cholecystokinin B receptor

protein:decreased expression:pancreas

NCBI chr21:29,602,066...29,606,343
Ensembl chr21:29,604,150...29,605,725

G

cyclin D1

severity

protein:increased expression:pancreas (human)

NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005

G

CD40 molecule

treatment

protein:increased expression:dendritic cell

PMID:20976171 PMID:21436454 PMID:23983255

RGD:11522743 RGD:5490301 RGD:5490524

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

cyclin dependent kinase 6

treatment

human cells in a mouse model

NCBI chr14:18,178,352...18,413,869
Ensembl chr14:18,188,429...18,419,869

G

cyclin dependent kinase inhibitor 1A

disease_progression

NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281

G

cyclin dependent kinase inhibitor 2A

CTD Direct Evidence: marker/mechanism

NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379

G

claudin 4

NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145

G

C-X-C motif chemokine ligand 11

CTD Direct Evidence: marker/mechanism

NCBI chr32:631,084...636,997
Ensembl chr32:631,478...632,868
Ensembl chr32:631,478...632,868

G

DNA methyltransferase 1

disease_progression

protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism

PMID:19424621 PMID:29844410

NCBI chr20:50,872,213...50,928,352
Ensembl chr20:50,879,527...50,928,029

G

DNA methyltransferase 3 beta

disease_progression

NCBI chr24:22,096,386...22,123,378
Ensembl chr24:22,096,349...22,122,900

G

deltex E3 ubiquitin ligase 1

CTD Direct Evidence: marker/mechanism

NCBI chr26:10,469,850...10,502,682

G

deltex E3 ubiquitin ligase 4

CTD Direct Evidence: marker/mechanism

NCBI chr18:37,535,957...37,570,937
Ensembl chr18:37,538,342...37,591,589

G

epidermal growth factor

disease_progression

protein:increased expression: :

NCBI chr32:30,073,541...30,166,904
Ensembl chr32:30,073,950...30,166,295

G

Fas ligand

protein:increased expression:pancreas, liver

PMID:10547193 PMID:15375495

RGD:2317741 RGD:2317747

NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224

G

fibroblast growth factor 2

disease_progression

PMID:12717266 PMID:18704599

RGD:2317756 RGD:2317758

NCBI chr19:17,403,288...17,463,143
Ensembl chr19:16,994,661...17,463,151

G

fascin actin-bundling protein 1

disease_progression

protein:increased expression:pancreas

NCBI chr 6:12,360,849...12,370,906
Ensembl chr 6:12,354,599...12,370,808

G

glycoprotein nmb

CTD Direct Evidence: marker/mechanism

NCBI chr14:36,919,184...36,947,023
Ensembl chr14:36,919,296...36,946,643

G

glutathione S-transferase pi 1

resistance

DNA:methylation: :
mRNA, protein:increased expression:pancreas

PMID:12488200 PMID:16537562 PMID:17265526

RGD:2317806 RGD:2317809 RGD:2317811

NCBI chr18:49,905,161...49,908,182
Ensembl chr18:49,905,161...49,908,182

G

histone deacetylase 1

disease_progression

protein:increased expression:pancreas

NCBI chr 2:68,901,339...68,936,473
Ensembl chr 2:68,901,651...68,936,186

G

HEAT repeat containing 1

treatment

NCBI chr 4:3,501,191...3,547,212
Ensembl chr 4:3,501,571...3,547,100

G

hes family bHLH transcription factor 1

CTD Direct Evidence: marker/mechanism

G

hes related family bHLH transcription factor with YRPW motif 1

CTD Direct Evidence: marker/mechanism

NCBI chr29:27,185,191...27,188,121
Ensembl chr29:27,185,191...27,188,121

G

hes related family bHLH transcription factor with YRPW motif 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:64,630,656...64,646,546

G

heat shock protein 70

CTD Direct Evidence: marker/mechanism

NCBI chr12:1,285,282...1,287,670

G

insulin like growth factor 1

NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794

G

insulin like growth factor 1 receptor

protein:increased expression:pancreas

PMID:14506643 PMID:14627343

RGD:2317649 RGD:2317652

NCBI chr 3:41,795,337...42,096,255
Ensembl chr 3:41,794,623...42,090,387

G

interleukin 4

NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534

G

interleukin 4 receptor

protein:increased expression:pancreas

NCBI chr 6:19,254,183...19,280,973
Ensembl chr 6:19,254,487...19,389,291

G

insulin

Glucagon/insulin

NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122

G

jagged canonical Notch ligand 1

CTD Direct Evidence: marker/mechanism

NCBI chr24:11,656,926...11,693,146
Ensembl chr24:11,657,416...11,692,199

G

jagged canonical Notch ligand 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:72,535,539...72,553,531
Ensembl chr 8:72,535,107...72,550,322

G

lysine demethylase 2B

severity

mRNA, protein:increased expression:pancreas (human)

NCBI chr26:7,625,857...7,746,049
Ensembl chr26:7,598,931...7,745,113

G

KIT ligand

CTD Direct Evidence: marker/mechanism

NCBI chr15:29,591,068...29,671,985
Ensembl chr15:29,591,170...29,671,974

G

KRAS proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism

PMID:25347530 PMID:30654191

NCBI chr27:22,261,753...22,296,704
Ensembl chr27:22,257,941...22,293,369

G

keratin 7

disease_progression

NCBI chr27:2,812,709...2,827,451

G

L1 cell adhesion molecule

severity

protein:increased expression:pancreas (human)

NCBI chr X:121,708,695...121,722,819
Ensembl chr X:121,708,894...121,733,365

G

mesothelin

disease_progression

protein:increased secretion:serum
CTD Direct Evidence: marker/mechanism
DNA:hypomethylation:5'UTR

PMID:12874021 PMID:14576474 PMID:19818733 PMID:21775916 PMID:25347530

RGD:2326055 RGD:2326065

NCBI chr 6:39,827,985...39,834,945

G

mitogen-activated protein kinase kinase kinase 7

CTD Direct Evidence: marker/mechanism

NCBI chr12:49,669,849...49,740,039
Ensembl chr12:49,672,389...49,739,850

G

mitogen-activated protein kinase 3

treatment

human cells in mouse model

NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425

G

minichromosome maintenance complex component 7

mRNA, protein:increased expression:pancreatic duct

NCBI chr 6:9,492,654...9,499,846
Ensembl chr 6:9,492,573...9,499,855

G

MDM2 proto-oncogene

severity
onset

protein:increased expression:pancreas (human)
DNA:snp:promoter, intron:IVS1+309T>G (human)

PMID:15810085 PMID:19752772

RGD:2317414 RGD:2317416

NCBI chr10:10,936,288...10,963,118
Ensembl chr10:10,893,719...10,962,596

G

menin 1

protein:decreased expression:pancreas

NCBI chr18:52,346,747...52,352,884
Ensembl chr18:52,346,933...52,353,340

G

MET proto-oncogene, receptor tyrosine kinase

protein:increased expression:pancreatic duct (human)

NCBI chr14:55,599,047...55,711,626
Ensembl chr14:55,598,337...55,724,027

G

O-6-methylguanine-DNA methyltransferase

susceptibility

protein:increased activity, increased expression:ductal adenocarcinoma (human)
DNA:missense mutation:cds:p.L84F rs12917 (human)

PMID:9393761 PMID:16844323

RGD:2317648 RGD:2317664

NCBI chr28:38,204,611...38,427,482
Ensembl chr28:38,204,610...38,427,380

G

microRNA mir-142

CTD Direct Evidence: marker/mechanism

NCBI chr 9:32,977,393...32,977,455
Ensembl chr 9:32,977,382...32,977,468

G

matrix metallopeptidase 2

severity

protein:increased expression:pancreas

NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113

G

matrix metallopeptidase 9

protein:increased expression:blood
protein:increased expression:pancreas, serum

PMID:18706098 PMID:20332475

RGD:2325830 RGD:2325844

NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293

G

mucin 1, cell surface associated

disease_progression

protein:increased expression, altered localization:pancreas

PMID:14681945 PMID:18713982 PMID:19109152

RGD:2317983 RGD:2324616 RGD:2324633

NCBI chr 7:42,338,939...42,344,690
Ensembl chr 7:42,340,375...42,344,690

G

mucin 4, cell surface associated

disease_progression

mRNA:increased expression:pancreas
protein:increased expression:pancreas

PMID:12657964 PMID:16049287

RGD:2324942 RGD:2324946

NCBI chr33:29,061,372...29,084,938
Ensembl chr33:29,063,096...29,111,802

G

mucin 5AC, oligomeric mucus/gel-forming

disease_progression

mRNA:increased expression:pancreas

PMID:7657125 PMID:10227724

RGD:2324907 RGD:2324986

NCBI chr18:45,471,232...45,498,961

G

mucin 5B, oligomeric mucus/gel-forming

mRNA:increased expression:pancreas

NCBI chr18:45,517,479...45,545,765
Ensembl chr18:45,517,474...45,545,184

G

N-myc downstream regulated 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:29,689,294...29,745,964
Ensembl chr13:29,650,444...29,746,382

G

NFE2 like bZIP transcription factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr36:20,989,205...21,087,044
Ensembl chr36:20,989,360...21,012,524

G

non-metastatic cells 1, protein (NM23A) expressed in

protein:increased expression:pancreas (human)

NCBI chr 9:26,990,336...26,998,895
Ensembl chr 9:26,990,469...26,998,955

G

nitric oxide synthase 2

NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588

G

notch receptor 1

CTD Direct Evidence: marker/mechanism

PMID:19028876 PMID:19208345 PMID:20484026

RGD:2325323 RGD:2325324

NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277

G

notch receptor 3

CTD Direct Evidence: marker/mechanism

NCBI chr20:46,946,654...46,978,821
Ensembl chr20:46,937,485...46,978,219

G

notch receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr12:1,585,249...1,608,721
Ensembl chr12:1,587,918...1,607,760

G

neurotrophic receptor tyrosine kinase 3

disease_progression

protein:increased expression:pancreas

PMID:10209957 PMID:11295066

RGD:2325660 RGD:2325663

NCBI chr 3:51,131,470...51,491,112
Ensembl chr 3:51,138,751...51,513,024

G

oncostatin M

CTD Direct Evidence: marker/mechanism

NCBI chr26:23,421,787...23,439,332
Ensembl chr26:23,421,787...23,426,036

G

palladin, cytoskeletal associated protein

protein:increased expression, alternative form:pancreas, fibroblast

NCBI chr25:19,147,310...19,568,712
Ensembl chr25:19,146,898...19,553,679

G

paired box 6

protein:increased expression:pancreatic duct (human)

G

PMS1 homolog 1, mismatch repair system component

protein:increased expression:pancreatic duct

NCBI chr37:502,752...609,640
Ensembl chr37:502,747...790,904

G

peroxisome proliferator activated receptor gamma

disease_progression

NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981

G

prostaglandin-endoperoxide synthase 2

NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903

G

RELA proto-oncogene, NF-kB subunit

CTD Direct Evidence: marker/mechanism

NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875

G

ring finger protein 2

protein:increased expression:pancreas

NCBI chr 7:18,240,672...18,283,091
Ensembl chr 7:18,236,115...18,281,387

G

retinoid X receptor alpha

severity

NCBI chr 9:50,525,195...50,575,720
Ensembl chr 9:50,484,567...50,573,119

G

serpin family A member 1

mRNA, protein:increased expression:pancreas

NCBI chr 8:63,388,498...63,400,377
Ensembl chr 8:63,376,945...63,398,435

G

solute carrier family 2 member 2

protein:increased expression:pancreatic duct

NCBI chr34:35,368,583...35,398,197
Ensembl chr34:35,370,192...35,400,409

G

SMAD family member 4

disease_progression

NCBI chr 1:23,875,989...23,930,027
Ensembl chr 1:23,882,139...23,969,405

G

smoothened, frizzled class receptor

NCBI chr14:7,518,871...7,527,703
Ensembl chr14:7,518,856...7,528,033

G

serine/threonine kinase 11

CTD Direct Evidence: marker/mechanism

NCBI chr20:57,558,966...57,579,163
Ensembl chr20:57,559,424...57,579,118

G

transforming growth factor beta receptor 2

disease_progression

mRNA:increased expresssion:pancreas

PMID:10547197 PMID:17114585

RGD:2317498 RGD:2317500

NCBI chr23:13,886,869...13,946,480
Ensembl chr23:13,889,000...13,977,636

G

thrombospondin 1

disease_progression

DNA:hypermethylation:promoter (human)

PMID:12429967 PMID:19065635

RGD:2325022 RGD:2325025

NCBI chr30:6,770,212...6,786,875
Ensembl chr30:6,769,470...6,784,915

G

transmembrane serine protease 3

NCBI chr31:36,706,229...36,730,444
Ensembl chr31:36,707,723...36,730,520

G

tumor protein p53

CTD Direct Evidence: marker/mechanism

NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109

G

TSC complex subunit 2

severity

NCBI chr 6:38,865,509...38,898,977
Ensembl chr 6:38,865,507...38,898,960

G

vascular endothelial growth factor A

CTD Direct Evidence: marker/mechanism

NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965

G

von Hippel-Lindau tumor suppressor

DNA:hypermethylation:promoter (human)

NCBI chr20:8,206,616...8,211,347
Ensembl chr20:8,206,616...8,211,323

G

YEATS domain containing 2

CTD Direct Evidence: marker/mechanism

NCBI chr34:16,654,672...16,777,493
Ensembl chr34:16,654,493...16,777,506

G

zinc finger ZZ-type containing 3

CTD Direct Evidence: marker/mechanism

NCBI chr 6:69,180,465...69,278,740
Ensembl chr 6:69,180,349...69,277,596

pancreatic endocrine carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BRCA2 DNA repair associated

ClinVar Annotator: match by term: Neuroendocrine tumor of pancreas

PMID:15145354 PMID:22762150 PMID:25741868 PMID:29446198

NCBI chr25:7,734,450...7,797,851
Ensembl chr25:7,734,453...7,797,815

G

cut like homeobox 1

exacerbates

protein:increased expression:pancreas (human)

NCBI chr 6:7,820,154...8,108,236
Ensembl chr 6:7,820,764...8,195,631

G

death domain associated protein

disease_progression

DNA:frameshift, frameshift mutations, nonsense mutation, missense mutations:CDS:multiple (human)

NCBI chr12:2,755,960...2,760,687
Ensembl chr12:2,755,960...2,761,340

G

O-6-methylguanine-DNA methyltransferase

DNA:hypermethylation:promoter (human)

NCBI chr28:38,204,611...38,427,482
Ensembl chr28:38,204,610...38,427,380

G

partner and localizer of BRCA2

ClinVar Annotator: match by term: Neuroendocrine tumor of pancreas

PMID:17200668 PMID:17200671 PMID:17200672 PMID:24136930 PMID:25099575 More...

NCBI chr 6:22,209,711...22,237,798
Ensembl chr 6:22,209,384...22,237,745

G

placental growth factor

treatment
disease_progression

human cells in a mouse model
protein:increased expression:serum (human)

PMID:23463017 PMID:26861455

RGD:14349029 RGD:14349030

NCBI chr 8:48,059,554...48,110,534
Ensembl chr 8:48,059,552...48,075,170

pancreatic intraductal papillary-mucinous neoplasm

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

DNA:missense mutation:cds:p.E17K (human)

NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193

G

tumor protein p53

DNA:missense mutations: :multiple

NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109

G

vascular endothelial growth factor D

protein:increased expression:blood serum (human)

NCBI chr X:11,590,097...11,627,199
Ensembl chr X:11,590,089...11,626,486

Pancreatic Intraepithelial Neoplasia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

anterior gradient 2, protein disulphide isomerase family member

protein:increased expression:pancreas

NCBI chr14:31,303,784...31,316,752
Ensembl chr14:31,305,567...31,316,686

G

BMI1 proto-oncogene, polycomb ring finger

protein:increased expression:pancreatic acinar cell:
protein:increased expression:exocrine pancreas:

NCBI chr 2:10,818,232...10,828,473
Ensembl chr 2:10,818,232...10,833,613

G

chromobox 7

disease_progression

protein:decreased expression:pancreas

NCBI chr10:25,876,022...25,896,284
Ensembl chr10:25,876,016...25,893,501

G

cyclin D1

disease_progression

protein:increased expression:pancreas (human)

PMID:11751405 PMID:12882690

RGD:13462061 RGD:13464129

NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005

G

DNA methyltransferase 1

protein:increased expression:pancreas

NCBI chr20:50,872,213...50,928,352
Ensembl chr20:50,879,527...50,928,029

G

histone deacetylase 1

protein:increased expression:pancreas

NCBI chr 2:68,901,339...68,936,473
Ensembl chr 2:68,901,651...68,936,186

G

inhibitor of nuclear factor kappa B kinase subunit beta

severity
disease_progression

PMID:22056382 PMID:22406536

RGD:13838740 RGD:13838742

NCBI chr16:23,359,551...23,419,114
Ensembl chr16:23,359,813...23,419,075

pancreatic mucinous cystadenoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

KRAS proto-oncogene, GTPase

severity

DNA:mutations:cds:

NCBI chr27:22,261,753...22,296,704
Ensembl chr27:22,257,941...22,293,369

pancreatic solid pseudopapillary carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin D1

severity

protein:increased expression:pancreas (human)

NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005

vipoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

menin 1

CTD Direct Evidence: marker/mechanism

NCBI chr18:52,346,747...52,352,884
Ensembl chr18:52,346,933...52,353,340

G

somatostatin

CTD Direct Evidence: therapeutic

NCBI chr34:20,063,091...20,064,520
Ensembl chr34:20,063,090...20,064,557

Term paths to the root

Path 1
Term	Annotations
disease	15755
disease of anatomical entity	15375
endocrine system disease	6284
pancreas disease	956
Pancreatic Neoplasms	400
Pancreatic Benign Neoplasm +	14
islet cell tumor +	28
pancreatic cancer +	397

paths to the root