Pancreatic Neoplasms - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Pancreatic Neoplasms	go back to main search page
Accession:	DOID:9003100	browse the term
Synonyms:	exact_synonym:	Pancreas Neoplasms; pancreas neoplasm; pancreatic neoplasm
	narrow_synonym:	Borderline Exocrine Pancreatic Neoplasm
	xref:	EFO:0003860; EFO:1000133; NCI:C34035

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Rat (483) Mouse (506) Human (3225) Chinchilla (383) Bonobo (405) Dog (401) Squirrel (391) Pig (395) Green Monkey (398) Naked Mole-rat (380) All
Genes (405)

Adult Pancreatic Cancer

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 7:17,949,254...17,998,737
Ensembl chr 7:17,278,637...17,326,171

duodenal gastrinoma

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

menin 1

associated with Neuroendocrine Tumors; DNA:loss of heterozygosity: :

NCBI chr11:60,159,009...60,166,222
Ensembl chr11:63,499,962...63,507,164

Familial Pancreatic Carcinoma

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apolipoprotein A4

mRNA:increased expression:pancreas, carcinoma (human)

NCBI chr11:111,659,186...111,661,790
Ensembl chr11:115,591,788...115,594,382

G

ATM serine/threonine kinase

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:8755918 PMID:9443866 PMID:9463314 PMID:9887333 PMID:10330348 More...

NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041

G

BRCA1 associated RING domain 1

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:25085752 PMID:25741868 PMID:26315354 PMID:26467025 PMID:26787654 More...

NCBI chr2B:101,984,287...102,068,523
Ensembl chr2B:220,456,972...220,541,145

G

chromosome 9 C11orf65 homolog

ClinVar Annotator: match by term: Familial pancreatic carcinoma

NCBI chr11:103,195,244...103,352,211
Ensembl chr11:106,670,277...106,817,886

G

cyclin dependent kinase inhibitor 2A

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:7640518 PMID:7647780 PMID:7987387 PMID:8668202 PMID:9823374 More...

NCBI chr 9:21,803,862...21,831,322

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:1875403 PMID:2547513 PMID:3627975 PMID:7773929 PMID:8439212 More...

NCBI chr12:61,062,689...61,108,524
Ensembl chr12:63,679,293...63,724,335

G

SMAD family member 4

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:25741868 PMID:26467025 PMID:26900293 PMID:27611364 PMID:28283864 More...

NCBI chr18:44,402,112...44,456,779
Ensembl chr18:47,764,568...47,797,359

G

tumor protein p53

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:1565143 PMID:1565144 PMID:1631137 PMID:1683921 PMID:1978757 More...

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

gastrinoma

term browser

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RGD Reference(s)

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G

insulin like growth factor 1 receptor

mRNA and protein: increased expression::poor prognosis for high expression

NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974

G

menin 1

CTD Direct Evidence: marker/mechanism
DNA:mutations: :

PMID:15944766 PMID:17961653

NCBI chr11:60,159,009...60,166,222
Ensembl chr11:63,499,962...63,507,164

G

MET proto-oncogene, receptor tyrosine kinase

severity

associated with Zollinger-Ellison Syndrome; mRNA:increased expression:tumor (human)

NCBI chr 7:108,646,278...108,772,238
Ensembl chr 7:121,365,438...121,468,159

G

O-6-methylguanine-DNA methyltransferase

DNA:hypomethylation:promoter (human)

NCBI chr10:126,059,701...126,365,850
Ensembl chr10:130,305,485...130,609,422

G

solute carrier family 2 member 2

mRNA:decreased expression:pancreatic islet

PMID:8421107 PMID:12114701

RGD:2324976 RGD:2324977

NCBI chr 3:168,002,609...168,033,237
Ensembl chr 3:176,188,184...176,218,722

Gastro-Enteropancreatic Neuroendocrine Tumor

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RGD Reference(s)

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G

ATM serine/threonine kinase

disease_progression

associated with Neoplasm Metastasis;mRNA, protein: decreased expression:gastrointestinal system, multiple (human)

NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041

G

ATRX chromatin remodeler

severity

NCBI chr X:66,682,968...66,969,421
Ensembl chr X:76,795,574...77,083,486

G

CD53 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 1:113,517,715...113,546,466
Ensembl chr 1:126,799,910...126,826,714

G

CD86 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 3:119,151,884...119,217,641
Ensembl chr 3:126,059,008...126,124,339

G

class II major histocompatibility complex transactivator

CTD Direct Evidence: marker/mechanism

NCBI chr16:9,819,440...9,885,379
Ensembl chr16:11,041,434...11,090,485

G

C-X-C motif chemokine receptor 4

severity

protein:increased expression:colon (human)

NCBI chr2B:23,744,271...23,748,106
Ensembl chr2B:140,181,829...140,189,647

G

death domain associated protein

severity

NCBI chr 6:32,890,846...32,895,307
Ensembl chr 6:34,004,543...34,008,717

G

eomesodermin

CTD Direct Evidence: marker/mechanism

NCBI chr 3:27,601,829...27,608,701
Ensembl chr 3:27,925,086...27,930,274

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:8,075,951...8,105,573
Ensembl chr10:8,064,207...8,086,272

G

growth factor independent 1 transcriptional repressor

CTD Direct Evidence: marker/mechanism

NCBI chr 1:95,139,171...95,151,054
Ensembl chr 1:93,876,245...93,883,528

G

IKAROS family zinc finger 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:50,946,817...51,047,168
Ensembl chr 7:51,191,685...51,291,245

G

IKAROS family zinc finger 3

CTD Direct Evidence: marker/mechanism

NCBI chr17:17,459,438...17,498,452
Ensembl chr17:17,643,750...17,741,479

G

interleukin 10

CTD Direct Evidence: marker/mechanism

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

interleukin 2 receptor subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr22:18,039,469...18,069,952
Ensembl chr22:35,874,898...35,899,038

G

notch receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:82,457,829...82,615,142
Ensembl chr 1:117,538,243...117,612,840

G

POU class 2 homeobox 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:38,974,635...39,065,103
Ensembl chr19:47,570,891...47,611,589

G

protein tyrosine phosphatase receptor type C

CTD Direct Evidence: marker/mechanism

NCBI chr 1:174,246,389...174,364,893
Ensembl chr 1:178,556,104...178,672,994

G

RUNX family transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:24,097,321...24,164,065
Ensembl chr 1:25,073,134...25,137,335

G

serpin family A member 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:75,001,714...75,014,214
Ensembl chr14:94,334,258...94,345,419

Glucagonoma

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G

betacellulin

protein:increased expression:pancreas

NCBI chr 4:49,329,413...49,462,891
Ensembl chr 4:55,242,899...55,298,773

G

menin 1

DNA:deletion:exon
CTD Direct Evidence: marker/mechanism

PMID:17961653 PMID:20138042

NCBI chr11:60,159,009...60,166,222
Ensembl chr11:63,499,962...63,507,164

G

solute carrier family 2 member 2

mRNA:decreased expression:pancreatic islet

PMID:8421107 PMID:12114701

RGD:2324976 RGD:2324977

NCBI chr 3:168,002,609...168,033,237
Ensembl chr 3:176,188,184...176,218,722

G

somatostatin receptor 4

NCBI chr20:22,982,009...22,986,058
Ensembl chr20:23,333,320...23,334,766

insulinoma

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G

adrenomedullin

protein:increased expression:pancreas, plasma

NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842

G

betacellulin

protein:increased expression:pancreas

NCBI chr 4:49,329,413...49,462,891
Ensembl chr 4:55,242,899...55,298,773

G

CD40 molecule

NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994

G

cut like homeobox 1

disease_progression
exacerbates

mRNA:increased expression:pancreas (mouse)
protein:increased expression:pancreas (human)

NCBI chr 7:93,954,599...94,432,697
Ensembl chr 7:107,191,124...107,609,940

G

C-X-C motif chemokine ligand 12

protein:increased expression:pancreas

NCBI chr10:41,296,975...41,384,864
Ensembl chr10:44,552,480...44,564,231

G

insulin

protein:altered expression:blood
protein:altered localization:pancreas

PMID:2565624 PMID:8175958

RGD:2317266 RGD:2317268

NCBI chr11:2,200,785...2,202,579
Ensembl chr11:2,218,117...2,231,666

G

small ribosomal subunit protein uS19

G

menin 1

disease_progression

DNA:deletion:exon
CTD Direct Evidence: marker/mechanism
DNA:deletions:exons

PMID:12941803 PMID:17961653 PMID:19208834 PMID:20138042

RGD:2317288 RGD:2317292 RGD:2317310

NCBI chr11:60,159,009...60,166,222
Ensembl chr11:63,499,962...63,507,164

G

neural cell adhesion molecule 1

protein:increased expression:pancreas

NCBI chr11:107,845,507...108,160,441
Ensembl chr11:111,925,677...112,000,401

G

solute carrier family 2 member 2

mRNA:decreased expression:pancreatic islet
protein:increased expression:pancreatic B cell

PMID:8421107 PMID:12114701

RGD:2324976 RGD:2324977

NCBI chr 3:168,002,609...168,033,237
Ensembl chr 3:176,188,184...176,218,722

G

transforming growth factor alpha

protein:increased expression:pancreas

NCBI chr2A:70,510,727...70,617,628
Ensembl chr2A:71,625,196...71,731,461

G

transforming growth factor beta 1

mRNA, protein:decreased expression:pancreatic islet

NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973

Islet Cell Adenomatosis

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G

MAF bZIP transcription factor A

ClinVar Annotator: match by term: Islet cell adenomatosis

PMID:25741868 PMID:29339498 PMID:35406570

NCBI chr 8:140,178,322...140,181,152

islet cell tumor

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PubMed Reference(s)

RGD Reference(s)

Position

G

ATRX chromatin remodeler

disease_progression

protein:decreased expression:pancreas:

NCBI chr X:66,682,968...66,969,421
Ensembl chr X:76,795,574...77,083,486

G

cyclin dependent kinase 4

protein:increased expression:pancreas, islet of Langerhans (human)

NCBI chr12:31,174,446...31,178,597
Ensembl chr12:31,434,594...31,438,876

G

death domain associated protein

disease_progression

NCBI chr 6:32,890,846...32,895,307
Ensembl chr 6:34,004,543...34,008,717

G

proprotein convertase subtilisin/kexin type 1

protein:increased expression:insulinoma (rat)

NCBI chr 5:18,917,488...18,960,102
Ensembl chr 5:19,064,004...19,106,486

Islet Cell Tumor Syndrome

term browser

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Evidence

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PubMed Reference(s)

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G

farnesyltransferase, CAAX box, subunit beta

ClinVar Annotator: match by term: Chromaffinoma

NCBI chr14:45,568,511...45,643,952
Ensembl chr14:64,448,170...64,522,632

G

MYC associated factor X

ClinVar Annotator: match by term: Chromaffinoma

PMID:21685915 PMID:22452945 PMID:23666964 PMID:25741868 PMID:26070438 More...

NCBI chr14:45,588,366...45,683,828
Ensembl chr14:64,535,120...64,562,671

G

myelin protein zero

ClinVar Annotator: match by term: Chromaffinoma

PMID:12807974 PMID:17468193 PMID:19454582 PMID:23342407 PMID:24033266 More...

NCBI chr 1:136,691,245...136,720,958
Ensembl chr 1:140,626,039...140,631,273

G

neurofibromin 1

ClinVar Annotator: match by term: Chromaffinoma

PMID:1568247 PMID:8264648 PMID:8499944 PMID:8499945 PMID:8669813 More...

NCBI chr17:25,425,081...25,703,689
Ensembl chr17:26,160,855...26,439,295

G

ret proto-oncogene

ClinVar Annotator: match by term: Chromaffinoma

PMID:2008030 PMID:2660074 PMID:2904651 PMID:3078962 PMID:7536460 More...

NCBI chr10:40,050,396...40,103,629
Ensembl chr10:43,249,468...43,284,331

G

succinate dehydrogenase complex assembly factor 2

ClinVar Annotator: match by term: Chromaffinoma

NCBI chr11:56,729,314...56,746,075
Ensembl chr11:60,093,656...60,110,288

G

succinate dehydrogenase complex iron sulfur subunit B

ClinVar Annotator: match by term: Chromaffinoma

PMID:490809 PMID:2308387 PMID:9509062 PMID:9536098 PMID:11404820 More...

NCBI chr 1:15,962,383...15,998,056
Ensembl chr 1:17,018,542...17,054,509

G

succinate dehydrogenase complex subunit C

ClinVar Annotator: match by term: Chromaffinoma

PMID:12807974 PMID:17468193 PMID:19454582 PMID:22517554 PMID:22703879 More...

NCBI chr 1:136,724,663...136,773,038
Ensembl chr 1:140,635,685...140,682,736

G

transmembrane protein 127

ClinVar Annotator: match by term: Chromaffinoma

PMID:9536098 PMID:16266984 PMID:17576681 PMID:20154675 PMID:20923864 More...

NCBI chr2A:103,049,655...103,065,116
Ensembl chr2A:97,174,322...97,189,171

G

von Hippel-Lindau tumor suppressor

ClinVar Annotator: match by term: Chromaffinoma

PMID:7563486 PMID:7987306 PMID:8707293 PMID:8772572 PMID:8956040 More...

NCBI chr 3:10,077,630...10,089,499
Ensembl chr 3:10,430,143...10,440,234

Melanoma-Pancreatic Cancer Syndrome

term browser

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Object Name

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Evidence

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Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin dependent kinase inhibitor 2A

ClinVar Annotator: match by term: Melanoma-pancreatic cancer syndrome

PMID:2319082 PMID:2813514 PMID:5001868 PMID:7566978 PMID:7632931 More...

NCBI chr 9:21,803,862...21,831,322

non-functioning pancreatic endocrine tumor

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

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G

AT-rich interaction domain 1A

exacerbates

protein:decreased expression:endocrine pancreas (human)

NCBI chr 1:25,960,868...26,047,057
Ensembl chr 1:27,018,616...27,103,239

G

cyclin dependent kinase 4

associated with multiple endocrine neoplasia type 1;mRNA:increased expression:islet of Langerhans (human)

NCBI chr12:31,174,446...31,178,597
Ensembl chr12:31,434,594...31,438,876

G

cyclin dependent kinase 6

associated with multiple endocrine neoplasia type 1;mRNA:increased expression:islet of Langerhans (human)

NCBI chr 7:84,603,419...84,835,082

pancreatic acinar cell adenocarcinoma

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

B-Raf proto-oncogene, serine/threonine kinase

DNA:missense mutation, gene fusions:multiple (human)

NCBI chr 7:132,651,908...132,855,422
Ensembl chr 7:145,138,510...145,327,115

G

SRC proto-oncogene, non-receptor tyrosine kinase

disease_progression

NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634

pancreatic adenocarcinoma

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adhesion G protein-coupled receptor B1

mRNA:decreased expression:pancreas

NCBI chr 8:139,154,065...139,251,115
Ensembl chr 8:142,220,827...142,301,070

G

AKT serine/threonine kinase 3

severity

mRNA:increased expression:pancreas (human)

NCBI chr 1:219,107,482...219,463,140
Ensembl chr 1:224,480,784...224,824,838

G

baculoviral IAP repeat containing 2

exacerbates

mRNA:increased expression:pancreas (human)

NCBI chr11:97,298,736...97,324,966
Ensembl chr11:100,793,036...100,822,421

G

baculoviral IAP repeat containing 3

disease_progression

mRNA:increased expression:pancreas (human)

NCBI chr11:97,269,778...97,290,112
Ensembl chr11:100,763,274...100,785,194

G

baculoviral IAP repeat containing 5

exacerbates

mRNA:increased expression:pancreas (human)

NCBI chr17:72,292,332...72,303,493
Ensembl chr17:77,842,724...77,854,159

G

baculoviral IAP repeat containing 7

exacerbates

mRNA:increased expression:pancreas (human)

NCBI chr20:59,618,530...59,623,612
Ensembl chr20:61,157,302...61,161,932

G

carbonyl reductase 4

ClinVar Annotator: match by term: Pancreatic adenocarcinoma

PMID:9536098 PMID:17576681 PMID:25741868 PMID:28166811 PMID:28492532

NCBI chr 4:161,103,477...161,235,840
Ensembl chr 4:173,282,162...173,309,905

G

cyclin D1

severity

protein:increased expression:pancreas (human)

NCBI chr11:64,737,006...64,750,353

G

cyclin dependent kinase 4

treatment

human cells in a mouse model

NCBI chr12:31,174,446...31,178,597
Ensembl chr12:31,434,594...31,438,876

G

cyclin dependent kinase 6

treatment

human cells in a mouse model

NCBI chr 7:84,603,419...84,835,082

G

cyclin dependent kinase inhibitor 2A

DNA:missense mutations:cds:p.V126D, p.A148T (human)

NCBI chr 9:21,803,862...21,831,322

G

C-X-C motif chemokine receptor 4

NCBI chr2B:23,744,271...23,748,106
Ensembl chr2B:140,181,829...140,189,647

G

E2F transcription factor 1

treatment

Human cells in a mouse model

NCBI chr20:29,963,083...29,973,860
Ensembl chr20:31,103,764...31,110,604

G

histidine rich glycoprotein

disease_progression

NCBI chr 3:183,701,069...183,712,365
Ensembl chr 3:192,168,299...192,180,539

G

Janus kinase 1

treatment

human cell line in a mouse model

NCBI chr 1:64,083,562...64,315,909
Ensembl chr 1:65,973,904...66,024,991

G

mitogen-activated protein kinase kinase 1

severity
treatment

protein:increased expression:pancreas (human)
human tissue in a mouse model

PMID:19513748 PMID:28849200

RGD:13838804 RGD:13838840

NCBI chr15:45,337,117...45,438,826
Ensembl chr15:63,613,961...63,714,161

G

mitogen-activated protein kinase 1

severity

mRNA:increased expression:pancreas (human)

NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335

G

mitogen-activated protein kinase 10

severity

DNA:SNP:intron: (rs2589506) (human)

NCBI chr 4:78,326,129...78,756,794
Ensembl chr 4:89,059,579...89,392,196

G

mitogen-activated protein kinase 8

exacerbates

protein:increased phosphorylation:pancreas (human)

NCBI chr10:45,806,748...45,936,362

G

mitogen-activated protein kinase 9

NCBI chr 5:175,437,167...175,495,469
Ensembl chr 5:182,748,381...182,795,135

G

nuclear factor kappa B subunit 1

severity

mRNA:increased expression:pancreas (human)

NCBI chr 4:94,925,048...95,040,849
Ensembl chr 4:105,589,062...105,704,098

G

palladin, cytoskeletal associated protein

ClinVar Annotator: match by term: Pancreatic adenocarcinoma

PMID:9536098 PMID:10454945 PMID:11474289 PMID:17194196 PMID:17415588 More...

NCBI chr 4:160,718,475...161,140,436

G

plasminogen activator, tissue type

mRNA:increased expression:pancreas (human)

NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779

G

Rac family small GTPase 1

treatment

human cells in a mouse model

NCBI chr 7:7,039,379...7,068,866

G

Raf-1 proto-oncogene, serine/threonine kinase

treatment

human cells in a mouse model

NCBI chr 3:12,510,084...12,590,598
Ensembl chr 3:12,853,415...12,932,871

G

RAS like proto-oncogene B

treatment

human cells in a mouse model

NCBI chr2B:7,185,192...7,227,220
Ensembl chr2B:120,748,123...120,802,698

G

ralA binding protein 1

treatment

human cells in a mouse model

NCBI chr18:4,747,555...4,810,710
Ensembl chr18:7,028,188...7,090,934

G

SMAD family member 7

severity

human cell and construct in a mouse model

NCBI chr18:42,306,324...42,337,214

G

signal transducer and activator of transcription 1

ameliorates

protein:increased expression:pancreas (human)

NCBI chr2B:78,270,642...78,316,074
Ensembl chr2B:196,186,906...196,232,280

G

vascular endothelial growth factor C

exacerbates

protein:increased expression:pancreas (human)

NCBI chr 4:168,870,941...168,999,160
Ensembl chr 4:181,104,737...181,236,030

pancreatic adenosquamous carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

transforming growth factor beta 2

ameliorates

human cells in a mouse model

NCBI chr 1:193,907,398...194,005,800
Ensembl chr 1:198,758,751...198,859,041

pancreatic cancer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1,4-N-acetylglucosaminyltransferase

mRNA:increased expression:blood, mononuclear cell

NCBI chr 3:135,151,027...135,159,692
Ensembl chr 3:142,602,475...142,610,835

G

ATP binding cassette subfamily C member 2

mRNA, protein:increased expression:pancreas

NCBI chr10:96,385,534...96,458,571
Ensembl chr10:99,889,160...99,947,270

G

ATP binding cassette subfamily C member 3

severity

mRNA:increased expression:pancreas

Ensembl chr17:49,603,268...49,659,318

G

ATP binding cassette subfamily C member 5

mRNA:increased expression:pancreas

NCBI chr 3:180,956,139...181,054,112
Ensembl chr 3:189,122,590...189,219,492

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

CTD Direct Evidence: marker/mechanism

PMID:19648918 PMID:20103627 PMID:26098869

NCBI chr 9:104,354,115...104,399,057
Ensembl chr 9:132,989,574...133,010,324

G

angiotensin I converting enzyme

NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853

G

activin A receptor type 1

NCBI chr2B:44,994,175...45,133,490
Ensembl chr2B:162,234,823...162,297,805

G

activin A receptor type 1B

NCBI chr12:36,765,655...36,811,355
Ensembl chr12:37,541,867...37,566,660

G

activin A receptor type 2A

NCBI chr2B:11,933,683...12,020,287
Ensembl chr2B:152,253,826...152,288,385

G

ADAM metallopeptidase domain 15

mRNA:increased expression:pancreas, epithelial cell

NCBI chr 1:130,398,961...130,410,860
Ensembl chr 1:134,008,959...134,020,467

G

ADAM metallopeptidase domain 9

mRNA:increased expression:pancreas, epithelial cell

NCBI chr 8:38,298,194...38,406,706
Ensembl chr 8:35,473,278...35,581,192

G

adhesion G protein-coupled receptor E5

protein:increased expression:pancreas

NCBI chr19:13,944,894...13,972,041
Ensembl chr19:14,788,568...14,815,663

G

adrenomedullin

disease_progression

PMID:16841081 PMID:17363587

RGD:2325317 RGD:2325318

NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842

G

advanced glycosylation end-product specific receptor

protein:decreased expression:serum

NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641

G

angiotensin II receptor type 2

mRNA:increased expression:pancreas

NCBI chr X:105,252,903...105,257,171
Ensembl chr X:115,671,594...115,672,685

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:increased expression:pancreas

PMID:12203118 PMID:25826687

NCBI chr 7:17,949,254...17,998,737
Ensembl chr 7:17,278,637...17,326,171

G

AKT serine/threonine kinase 1

treatment
severity

human cells in a mouse model
protein:increased phosphorylation:pancreas (human)

PMID:11595724 PMID:20697673

RGD:13450953 RGD:13452388

NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756

G

albumin

disease_progression

PMID:18154768 PMID:20508721

RGD:2325675 RGD:2325678

NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418

G

aldehyde dehydrogenase 1 family member A1

protein:decreased expression:pancreas

NCBI chr 9:51,737,305...51,916,648
Ensembl chr 9:71,680,890...71,814,085

G

aldehyde dehydrogenase 2 family member

susceptibility

DNA:polymorphism: :p.E504K (human)
DNA:polymorphism (human)

PMID:15714130 PMID:19068087

RGD:2325313 RGD:2325694

NCBI chr12:109,343,020...109,385,060
Ensembl chr12:112,734,243...112,776,471

G

arachidonate 12-lipoxygenase, 12R type

CTD Direct Evidence: marker/mechanism

NCBI chr17:43,569,858...43,588,039
Ensembl chr17:48,302,450...48,317,029

G

arachidonate 5-lipoxygenase

protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism

PMID:12163367 PMID:12481414 PMID:30258081

RGD:2317523 RGD:2317524

NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016

G

angiogenin

disease_progression

mRNA, protein:increased expression:pancreas, serum

NCBI chr14:1,548,693...1,558,528
Ensembl chr14:19,614,950...19,615,393

G

annexin A1

protein:increased expression:pancreas

PMID:17974280 PMID:19173988

RGD:2325722 RGD:2325723

NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779

G

annexin A10

CTD Direct Evidence: marker/mechanism

NCBI chr 4:160,297,246...160,394,825
Ensembl chr 4:172,412,718...172,472,033

G

apoptotic peptidase activating factor 1

mRNA:increased expression:pancreas

NCBI chr12:96,224,515...96,311,246
Ensembl chr12:99,637,622...99,726,939

G

APC regulator of WNT signaling pathway

ClinVar Annotator: match by term: Cancer of the pancreas

PMID:1316610 PMID:8381579 PMID:9101302 PMID:9824584 PMID:11852337 More...

NCBI chr 5:108,070,697...108,208,273
Ensembl chr 5:113,904,352...114,009,709

G

apolipoprotein A1

protein:decreased expression:serum
protein:increased expression:pancreas

PMID:17312459 PMID:17332923

RGD:2325757 RGD:2325758

NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122

G

apolipoprotein E

protein:increased expression:pancreas (human)

NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490

G

actin related protein 2/3 complex subunit 1A

DNA:amplification (human)

NCBI chr 7:91,299,559...91,339,729
Ensembl chr 7:104,801,399...104,841,590

G

artemin

disease_progression

mRNA:increased expression:pancreas

PMID:19304517 PMID:20395845

RGD:2325815 RGD:2325817

NCBI chr 1:43,233,097...43,239,044

G

ATM serine/threonine kinase

susceptibility

DNA:SNP:exon:rs1801516(human)
ClinVar Annotator: match by term: Pancreatic cancer

PMID:8698354 PMID:8845835 PMID:9497252 PMID:9536098 PMID:9792409 More...

NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041

G

ATR serine/threonine kinase

DNA:SNP: :340C>T (human)

NCBI chr 3:139,482,606...139,612,274
Ensembl chr 3:147,075,185...147,196,261

G

ATRX chromatin remodeler

CTD Direct Evidence: marker/mechanism

NCBI chr X:66,682,968...66,969,421
Ensembl chr X:76,795,574...77,083,486

G

AXL receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr19:38,211,555...38,254,464
Ensembl chr19:46,719,615...46,761,747

G

beta-1,3-galactosyltransferase 5

mRNA:increased expression:pancreas

NCBI chr21:25,909,993...26,027,130
Ensembl chr21:39,346,707...39,350,305

G

BCL2 associated agonist of cell death

treatment

human cells in a mouse model

NCBI chr11:59,626,981...59,641,824
Ensembl chr11:62,971,808...62,986,257

G

BAG cochaperone 3

mRNA:increased expression:pancreas

NCBI chr10:116,221,747...116,248,692
Ensembl chr10:119,643,963...119,665,964

G

BAG cochaperone 4

mRNA:increased expression:pancreas

NCBI chr 8:37,479,231...37,515,303
Ensembl chr 8:34,656,000...34,692,666

G

BRCA1 associated deubiquitinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:52,344,067...52,352,187
Ensembl chr 3:53,573,785...53,581,943

G

BCAR1 scaffold protein, Cas family member

CTD Direct Evidence: marker/mechanism

NCBI chr16:55,798,578...55,838,448
Ensembl chr16:75,150,122...75,188,775

G

BCL2 like 1

severity

human gene in a mouse model
CTD Direct Evidence: marker/mechanism

PMID:16904634 PMID:17941720

NCBI chr20:27,955,688...28,015,950
Ensembl chr20:29,088,055...29,146,585

G

BH3 interacting domain death agonist

NCBI chr22:1,164,787...1,205,051
Ensembl chr22:16,594,186...16,632,844

G

B-Raf proto-oncogene, serine/threonine kinase

disease_progression

human gene in a mouse model

PMID:18490924 PMID:22628411 PMID:22871572

RGD:13451537 RGD:13461863 RGD:13462040

NCBI chr 7:132,651,908...132,855,422
Ensembl chr 7:145,138,510...145,327,115

G

BRCA1 DNA repair associated

ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4

PMID:1157798 PMID:2173504 PMID:2316185 PMID:2504116 PMID:2618727 More...

NCBI chr17:14,197,946...14,279,064
Ensembl chr17:14,428,526...14,506,815

G

BRCA2 DNA repair associated

susceptibility

ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2
DNA:mutations: :
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2

ClinVar
RGD
OMIM

PMID:186727 PMID:251866 PMID:278235 PMID:1772447 PMID:2200631 More...

NCBI chr13:13,574,422...13,658,967
Ensembl chr13:32,010,066...32,091,332

G

basigin (Ok blood group)

CTD Direct Evidence: marker/mechanism

Ensembl chr19:539,815...551,456

G

BUB1 mitotic checkpoint serine/threonine kinase B

protein:altered localization:pancreas

NCBI chr15:19,095,383...19,155,557
Ensembl chr15:37,350,826...37,410,648

G

calcium binding protein 39

disease_progression

NCBI chr2B:117,965,688...118,074,063
Ensembl chr2B:236,809,549...236,870,646

G

calcyclin binding protein

disease_progression

mRNA, protein:increased expression:pancreas

NCBI chr 1:150,511,021...150,522,369
Ensembl chr 1:154,210,001...154,220,583

G

cyclase associated actin cytoskeleton regulatory protein 1

disease_progression

mRNA, protein:increased expression:pancreas

NCBI chr 1:39,325,715...39,358,365
Ensembl chr 1:40,651,262...40,683,777

G

calpain 10

susceptibility

DNA:SNP:intron:rs3792267 (human)

NCBI chr2B:127,838,477...127,851,334
Ensembl chr2B:246,645,630...246,679,169

G

caspase 8

susceptibility

DNA:SNP: :rs1045485 (human)
DNA:deletion, insertion:promoter (human)

PMID:18483392 PMID:19843670

RGD:2315744 RGD:2317230

NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468

G

caspase 9

susceptibility
treatment

DNA:snp:promoter:g.-1263A>G (human)

PMID:19209030 PMID:20357690

RGD:13451540 RGD:13462046

NCBI chr 1:14,630,659...14,662,865
Ensembl chr 1:15,624,666...15,656,266

G

catalase

disease_progression

protein:decreased expression:pancreas

NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160

G

carbonyl reductase 4

ClinVar Annotator: match by term: PALLD-related condition | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1

PMID:25741868 PMID:28492532

NCBI chr 4:161,103,477...161,235,840
Ensembl chr 4:173,282,162...173,309,905

G

cholecystokinin A receptor

mRNA:increased expression:pancreas

PMID:8222074 PMID:10457335

RGD:4110817 RGD:4110822

NCBI chr 4:20,881,340...20,890,986
Ensembl chr 4:26,157,702...26,166,773

G

cholecystokinin B receptor

susceptibility
disease_progression

mRNA:increased expression:pancreas

PMID:1458479 PMID:8222074 PMID:8302799 PMID:15688412

RGD:4110821 RGD:4110822 RGD:4110823 RGD:4110829

NCBI chr11:6,393,435...6,405,821
Ensembl chr11:6,075,816...6,088,145

G

C-C motif chemokine ligand 20

CTD Direct Evidence: marker/mechanism

PMID:10225458 PMID:30603057

NCBI chr2B:115,052,768...115,056,479
Ensembl chr2B:233,862,505...233,866,225

G

C-C motif chemokine ligand 5

NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172

G

cyclin D1

treatment
disease_progression

human cells in a mouse model
mRNA, protein:increased expression:pancreas (mouse)

PMID:11159909 PMID:17541034 PMID:22722256

RGD:13451541 RGD:13452385 RGD:13462059

NCBI chr11:64,737,006...64,750,353

G

cyclin G1

treatment

human cells in mouse model

NCBI chr 5:158,814,563...158,822,019
Ensembl chr 5:165,592,971...165,598,728

G

C-C motif chemokine receptor 4

protein:increased expression:pancreas

NCBI chr 3:32,882,419...32,887,442
Ensembl chr 3:33,188,482...33,189,564

G

C-C motif chemokine receptor 5

NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379

G

CD44 molecule (IN blood group)

CTD Direct Evidence: marker/mechanism

NCBI chr11:35,110,732...35,258,238
Ensembl chr11:34,985,634...35,079,009

G

cell division cycle 42

severity

mRNA, protein:increased expression:pancreas (human)

NCBI chr 1:21,245,970...21,286,210

G

cadherin 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:49,108,745...49,206,347
Ensembl chr16:68,502,584...68,596,488

G

cyclin dependent kinase 4

disease_progression
susceptibility

protein:increased expression:islet of Langerhans, nucleus (rat)
protein:increased expression:pancreas (mouse)
protein:increased expression:islet of Langerhans (human)

PMID:11159909 PMID:22477723 PMID:22761470 PMID:24531709

RGD:13452384 RGD:13452385 RGD:13452386 RGD:13452387

NCBI chr12:31,174,446...31,178,597
Ensembl chr12:31,434,594...31,438,876

G

cyclin dependent kinase inhibitor 2A

CTD Direct Evidence: marker/mechanism
DNA:mutations:exon

PMID:10627132 PMID:18772397 PMID:26098869

NCBI chr 9:21,803,862...21,831,322

G

CASP8 and FADD like apoptosis regulator

CTD Direct Evidence: marker/mechanism

NCBI chr2B:88,373,057...88,429,959
Ensembl chr2B:206,528,943...206,577,045

G

CF transmembrane conductance regulator

onset
no_association

PMID:16227367 PMID:17072959

RGD:2317156 RGD:2317157

NCBI chr 7:109,449,847...109,633,023
Ensembl chr 7:122,129,798...122,327,864

G

checkpoint kinase 1

disease_progression

DNA:SNP: :35G>A (human)

NCBI chr11:120,446,352...120,478,207
Ensembl chr11:124,359,218...124,390,981

G

claudin 4

PMID:19555390 PMID:19793693

RGD:2317580 RGD:2317583

Ensembl chr 7:80,983,832...80,984,461

G

CLPTM1 regulator of GABA type A receptor forward trafficking

CTD Direct Evidence: marker/mechanism

NCBI chr19:41,901,649...41,940,476
Ensembl chr19:50,506,886...50,545,204

G

cannabinoid receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:86,017,141...86,044,889

G

cannabinoid receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:23,066,153...23,108,065
Ensembl chr 1:24,050,008...24,051,090

G

catenin beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030

G

C-X-C motif chemokine ligand 8

CTD Direct Evidence: marker/mechanism

NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083

G

cytochrome P450 family 17 subfamily A member 1

susceptibility

DNA:transition:5' utr:-34T>C rs743572 (human)

NCBI chr10:99,431,762...99,439,619
Ensembl chr10:102,896,376...102,901,514

G

death domain associated protein

CTD Direct Evidence: marker/mechanism

NCBI chr 6:32,890,846...32,895,307
Ensembl chr 6:34,004,543...34,008,717

G

discoidin domain receptor tyrosine kinase 1

treatment

NCBI chr 6:30,625,871...30,645,066
Ensembl chr 6:31,496,047...31,513,455

G

dihydropyrimidine dehydrogenase

disease_progression

CTD Direct Evidence: marker/mechanism
protein:increased expression:pancreas

PMID:17443278 PMID:18309485 PMID:19020767 PMID:20072795

RGD:2317629 RGD:2317630

NCBI chr 1:99,736,145...100,576,663
Ensembl chr 1:98,457,934...99,300,100

G

dual specificity tyrosine phosphorylation regulated kinase 1A

CTD Direct Evidence: marker/mechanism

NCBI chr21:23,729,204...23,878,820
Ensembl chr21:37,137,253...37,231,987

G

E2F transcription factor 1

treatment

NCBI chr20:29,963,083...29,973,860
Ensembl chr20:31,103,764...31,110,604

G

EGF containing fibulin extracellular matrix protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr2A:56,017,678...56,076,059
Ensembl chr2A:57,155,000...57,212,500

G

epidermal growth factor

disease_progression

protein:increased expression:pancreas

NCBI chr 4:102,410,724...102,509,691
Ensembl chr 4:112,977,565...113,076,460

G

epidermal growth factor receptor

CTD Direct Evidence: marker/mechanism

PMID:17452677 PMID:27720938

NCBI chr 7:55,614,042...55,807,285
Ensembl chr 7:56,046,296...56,111,615

G

epithelial cell adhesion molecule

CTD Direct Evidence: marker/mechanism

NCBI chr2A:47,490,748...47,508,418
Ensembl chr2A:48,413,520...48,432,038

G

EPH receptor A3

NCBI chr 3:89,261,166...89,629,010
Ensembl chr 3:91,369,239...91,739,056

G

ERCC excision repair 1, endonuclease non-catalytic subunit

susceptibility

DNA:snp:3' utr:c.*197G>T (rs3212986) (human)

NCBI chr19:42,356,039...42,427,754
Ensembl chr19:50,951,674...50,968,430

G

ERCC excision repair 2, TFIIH core complex helicase subunit

treatment

pancreatic adenocarcinoma;DNA:SNPs: :rs1799793,rs1052555(human)
DNA,protein:SNPs:exons:rs1799793,rs1052559

PMID:16458430 PMID:18544627 PMID:21404106

RGD:11252206 RGD:2317223 RGD:2317228

NCBI chr19:42,298,927...42,319,816
Ensembl chr19:50,897,004...50,915,819

G

ERCC excision repair 4, endonuclease catalytic subunit

pancreatic adenocarcinoma;DNA:SNP: :rs1800067(human)

NCBI chr16:12,848,334...12,880,480
Ensembl chr16:14,272,417...14,304,496

G

ETAA1 activator of ATR kinase

CTD Direct Evidence: marker/mechanism

NCBI chr2A:67,455,668...67,470,509
Ensembl chr2A:68,578,554...68,591,534

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

protein:increased expression:pancreas

NCBI chr 7:140,536,962...140,613,104
Ensembl chr 7:153,017,590...153,059,726

G

FA complementation group A

DNA,Protein:polymorphisms:exons:c.377C>G, c.661A>G (human)

NCBI chr16:70,495,310...70,579,275
Ensembl chr16:90,163,950...90,245,147

G

FA complementation group C

DNA:nonsense mutation (human)

PMID:15695377 PMID:16243825

RGD:2317238 RGD:2317239

NCBI chr 9:66,201,581...66,418,229
Ensembl chr 9:94,329,971...94,477,198

G

FA complementation group G

NCBI chr 9:34,924,399...34,931,077
Ensembl chr 9:35,730,176...35,736,648

G

Fas ligand

severity
resistance

DNA:polymorphism:promoter:-844>>T (human)

PMID:11115536 PMID:12370548 PMID:18483392

RGD:2315744 RGD:2317744 RGD:2317745

NCBI chr 1:148,159,826...148,167,785
Ensembl chr 1:151,868,430...151,876,281

G

fibroblast growth factor 13

CTD Direct Evidence: marker/mechanism

NCBI chr X:127,764,648...128,353,928
Ensembl chr X:138,023,016...138,103,217

G

fibroblast growth factor 2

severity

protein:increased expression:bile
mRNA:increased expression:pancreas

PMID:9293890 PMID:11478488 PMID:11562741 PMID:12670449

RGD:2317759 RGD:2317760 RGD:2317762 RGD:2317765

NCBI chr 4:115,005,136...115,076,369
Ensembl chr 4:126,149,813...126,214,942

G

fms related receptor tyrosine kinase 3 ligand

NCBI chr19:46,486,169...46,499,008

G

forkhead box P1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:70,893,933...71,523,892
Ensembl chr 3:72,258,456...72,498,173

G

fascin actin-bundling protein 1

severity

protein:increased expression:pancreas

NCBI chr 7:5,848,902...5,862,756

G

FXYD domain containing ion transport regulator 3

CTD Direct Evidence: marker/mechanism

NCBI chr19:32,036,936...32,070,374

G

growth arrest and DNA damage inducible alpha

CTD Direct Evidence: therapeutic

NCBI chr 1:66,925,063...66,928,222
Ensembl chr 1:68,880,912...68,884,188

G

glial cell derived neurotrophic factor

severity

NCBI chr 5:72,539,374...72,566,918
Ensembl chr 5:77,577,313...77,601,362

G

GNAS complex locus

NCBI chr20:55,190,607...55,262,245

G

golgi membrane protein 1

NCBI chr 9:38,823,820...38,910,984
Ensembl chr 9:83,005,832...83,080,202

G

glutathione S-transferase pi 1

susceptibility

DNA:SNP:cds:p.I105V (rs1695) (human)

PMID:19536452 PMID:19786118

RGD:2317804 RGD:2317805

NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472

G

hepatocyte growth factor

protein:increased expression:serum

NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811

G

hypoxia inducible factor 1 subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885

G

heparan sulfate-glucosamine 3-sulfotransferase 2

DNA:hypermethylation:promoter (human)

NCBI chr16:15,195,577...15,297,155
Ensembl chr16:23,067,554...23,168,609

G

heat shock protein family B (small) member 1

disease_progression

NCBI chr 7:67,716,021...67,717,762
Ensembl chr 7:82,751,523...82,752,984

G

intercellular adhesion molecule 1

mRNA, protein:increased expression:pancreas

NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605

G

interferon gamma

protein:increased expression:plasma

NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829

G

insulin like growth factor 1

susceptibility

DNA:polymorphism (human)

NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177

G

insulin like growth factor 1 receptor

PMID:14559833 PMID:19732452 PMID:19885860

RGD:2317640 RGD:2317642 RGD:2317651

NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974

G

interleukin 10

disease_progression
susceptibility

protein:increased expression:serum
DNA:polymorphism: :-1082G>A (human)

PMID:17235586 PMID:19250218 PMID:30304975 PMID:30610790

RGD:14975253 RGD:14975257 RGD:2317653 RGD:2317655

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

interleukin 13

disease_progression

protein:increased expression:pancreas

PMID:12808442 PMID:18758789

RGD:2317669 RGD:2317670

NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548

G

interleukin 13 receptor subunit alpha 2

treatment

NCBI chr X:104,092,993...104,146,062
Ensembl chr X:114,597,077...114,635,253

G

interleukin 1 alpha

NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801

G

interleukin 1 beta

susceptibility

protein:increased expression:serum (human)
DNA:polymorphisms:promoter:-511C>T, -31T>C (human)

PMID:7787209 PMID:19251436

RGD:2311069 RGD:2317215

NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424

G

interleukin 2

treatment

NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984

G

interleukin 24

CTD Direct Evidence: therapeutic

NCBI chr 1:182,500,680...182,507,098
Ensembl chr 1:186,779,207...186,785,928

G

interleukin 3

protein:increased expression:serum

NCBI chr 5:127,483,843...127,486,388
Ensembl chr 5:133,647,667...133,650,213

G

interleukin 4

disease_progression

protein:increased expression:blood

PMID:10404069 PMID:12097255 PMID:19957810

RGD:2317261 RGD:2317265 RGD:2317267

NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581

G

interleukin 4 receptor

disease_progression

protein:increased expression:pancreas

Ensembl chr16:27,642,702...27,737,445

G

interleukin 6

disease_progression

PMID:30304975 PMID:30610790

RGD:14975253 RGD:14975257

NCBI chr 7:23,415,922...23,420,767

G

integrin linked kinase

DNA:mutations:exon

NCBI chr11:6,735,735...6,742,922
Ensembl chr11:6,418,717...6,425,788

G

inositol polyphosphate-4-phosphatase type II B

CTD Direct Evidence: marker/mechanism

NCBI chr 4:134,405,934...135,213,851
Ensembl chr 4:145,706,307...146,141,029

G

insulin

susceptibility
disease_progression

associated with Diabetes Mellitus, Non-Insulin-Depend
DNA:Polymorphism:promoter:-23 HphI (human)

PMID:19152242 PMID:19375425 PMID:19572116 PMID:19628082

RGD:2317245 RGD:2317247 RGD:2317250 RGD:2317253

NCBI chr11:2,200,785...2,202,579
Ensembl chr11:2,218,117...2,231,666

G

integrin subunit alpha 11

DNA:mutations:exon

NCBI chr15:47,260,931...47,390,062
Ensembl chr15:66,031,201...66,128,985

G

integrin subunit alpha 4

DNA:mutations:exon

NCBI chr2B:68,719,376...68,802,488
Ensembl chr2B:186,530,187...186,612,203

G

integrin subunit alpha 9

DNA:mutations:exon

NCBI chr 3:37,349,120...37,722,572
Ensembl chr 3:37,651,395...38,006,363

G

kinase insert domain receptor

CTD Direct Evidence: therapeutic

PMID:12385004 PMID:19930156

NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109

G

KLF transcription factor 5

CTD Direct Evidence: marker/mechanism

G

KRAS proto-oncogene, GTPase

disease_progression

NCBI chr12:61,062,689...61,108,524
Ensembl chr12:63,679,293...63,724,335

G

L1 cell adhesion molecule

treatment

NCBI chr X:143,412,303...143,437,090
Ensembl chr X:153,298,690...153,324,228

G

lactate dehydrogenase A

CTD Direct Evidence: marker/mechanism

NCBI chr11:18,432,347...18,445,694
Ensembl chr11:18,115,250...18,128,400

G

DNA ligase 3

resistance

DNA:SNP:intron:rs 2074522 (human)

NCBI chr17:21,776,483...21,805,706
Ensembl chr17:22,074,046...22,095,220

G

DNA ligase 4

susceptibility

associated with Diabetes Mellitus;DNA:polymorphism: :54C>T (human)

NCBI chr13:89,336,434...89,347,418
Ensembl chr13:108,475,820...108,478,555

G

alcohol dehydrogenase 1C

DNA:polymorphism: :p.R272Q (human)

NCBI chr 4:91,756,817...91,773,056
Ensembl chr 4:102,388,575...102,435,079

G

interferon alpha-2

CTD Direct Evidence: therapeutic

NCBI chr 9:21,245,017...21,246,210
Ensembl chr 9:21,863,062...21,863,736

G

signal transducer CD24

CTD Direct Evidence: marker/mechanism

NCBI chr 6:104,783,720...104,789,509
Ensembl chr 6:108,655,624...108,657,847

G

cytochrome c

NCBI chr 7:25,784,900...25,791,598
Ensembl chr 7:25,396,013...25,398,549

G

eukaryotic initiation factor 4A-III

protein:increased expression:serum (human)

NCBI chr17:74,221,793...74,233,738

G

lumican

disease_progression

DNA:SNP: :rs2268578 (human)

PMID:17671699 PMID:19843670

RGD:2317230 RGD:2317682

NCBI chr12:88,636,825...88,644,665
Ensembl chr12:91,952,277...91,960,388

G

lymphocyte antigen 6 family member E

CTD Direct Evidence: marker/mechanism

G

mesencephalic astrocyte derived neurotrophic factor

no_association

DNA:point mutations, deletions:cds:multiple (human)
DNA:polymorphisms: :multiple (human)

PMID:9174057 PMID:17072959

RGD:2317157 RGD:2325804

NCBI chr 3:51,315,948...51,320,022
Ensembl chr 3:52,548,933...52,554,343

G

mitogen-activated protein kinase kinase 4

DNA:mutations:exon

NCBI chr17:39,497,105...39,622,331
Ensembl chr17:44,248,857...44,359,909

G

menin 1

associated with Neuroendocrine Tumors; protein:increased expression:multiple organs
CTD Direct Evidence: marker/mechanism

PMID:17278096 PMID:17961653 PMID:21252315

NCBI chr11:60,159,009...60,166,222
Ensembl chr11:63,499,962...63,507,164

G

MET proto-oncogene, receptor tyrosine kinase

severity

protein:increased expression:pancreas (rat)
mRNA:increased expression:pancreas (human)

PMID:9211490 PMID:15448002

RGD:2317235 RGD:2317613

NCBI chr 7:108,646,278...108,772,238
Ensembl chr 7:121,365,438...121,468,159

G

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

NCBI chr2A:100,573,320...100,692,840
Ensembl chr2A:99,533,831...99,641,579

G

O-6-methylguanine-DNA methyltransferase

protein:decreased expression:neuroendocrine tumor (human)

NCBI chr10:126,059,701...126,365,850
Ensembl chr10:130,305,485...130,609,422

G

marker of proliferation Ki-67

disease_progression

protein:increased expression:pancreas

PMID:20137856 PMID:20350215

RGD:2317703 RGD:2317704

NCBI chr10:124,684,336...124,714,143
Ensembl chr10:128,936,037...128,962,555

G

matrix metallopeptidase 2

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:pancreas
protein:increased activity:pancreatic juice

PMID:7635566 PMID:11961486 PMID:30603057

RGD:2325752 RGD:2325766

NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279

G

matrix metallopeptidase 9

disease_progression

CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
mRNA:increased expression:pancreas

PMID:7635566 PMID:18030366 PMID:18445772 PMID:19629003 PMID:22952646

RGD:2325766 RGD:2325831 RGD:2325849 RGD:2325854

NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129

G

myeloperoxidase

resistance

DNA:polymorphism:promoter:-463G>A (human)

NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111

G

mesothelin

associated with Pancreatic Disease; protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism

PMID:11751476 PMID:17019794 PMID:17785569 PMID:18281514 PMID:19843662

RGD:2326052 RGD:2326056 RGD:2326060 RGD:2326062

Ensembl chr16:777,146...783,449

G

methylthioadenosine phosphorylase

DNA, protein:deletion, decreased activity:pancreas:

NCBI chr 9:21,637,543...21,769,698
Ensembl chr 9:22,266,376...22,382,218

G

methylenetetrahydrofolate reductase

susceptibility

DNA:polymorphism: :677C>T (human)

NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419

G

mechanistic target of rapamycin kinase

NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841

G

5-methyltetrahydrofolate-homocysteine methyltransferase

susceptibility
no_association

DNA:Polymorphism: :rs1805087 (human)

PMID:16737574 PMID:18843018

RGD:2317118 RGD:2317120

NCBI chr 1:212,353,195...212,463,304
Ensembl chr 1:217,358,050...217,460,946

G

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

susceptibility

DNA:SNPs:intron, exon:rs162049, p.H595Y (rs10380) (human)
DNA:polymorphism: :66A>G (human)

PMID:18515090 PMID:18843018

RGD:2317118 RGD:2325772

NCBI chr 5:8,195,868...8,228,071
Ensembl chr 5:8,017,403...8,049,322

G

mucin 1, cell surface associated

disease_progression

protein:increased secretion:bile
protein:increased expression:pancreas

PMID:14654947 PMID:18039393 PMID:18383873 PMID:18575732 PMID:19055478 More...

RGD:2317984 RGD:2317987 RGD:2324622 RGD:2324635 RGD:2324637 RGD:2324639

NCBI chr 1:130,533,508...130,537,866
Ensembl chr 1:134,141,969...134,145,850

G

mucin 16, cell surface associated

protein:increased expression:serum

NCBI chr19:8,416,393...8,568,418

G

mucin 4, cell surface associated

disease_progression

protein:increased expression:pancreas
mRNA:increased expression:peripheral blood mononuclear cell
mRNA:increased expression:pancreas

PMID:11751498 PMID:16274046 PMID:17406026 PMID:17595659 PMID:20303649

RGD:2324891 RGD:2324914 RGD:2324922 RGD:2324923 RGD:2324931

NCBI chr 3:193,050,895...193,114,931

G

mucin 5AC, oligomeric mucus/gel-forming

protein:increased expression:pancreas
protein:increased glycosylation:serum

PMID:14654947 PMID:19377061

RGD:2317984 RGD:2325129

NCBI chr11:1,191,223...1,234,373

G

mucin 6, oligomeric mucus/gel-forming

protein:increased expression: :

NCBI chr11:1,035,447...1,071,791
Ensembl chr11:1,077,867...1,106,927

G

MYC proto-oncogene, bHLH transcription factor

CTD Direct Evidence: marker/mechanism

PMID:22024988 PMID:25961927

NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863

G

nucleosome assembly protein 1 like 1

human gene in a mouse model

NCBI chr12:73,549,887...73,589,621
Ensembl chr12:76,402,906...76,441,815

G

N-acetyltransferase 1

susceptibility

DNA:polymorphism (human)
DNA:polymorphisms,haplotype: :

PMID:18006927 PMID:18499698

RGD:2317168 RGD:2317170

NCBI chr 8:17,425,852...17,439,684
Ensembl chr 8:14,386,481...14,392,462

G

N-acetyltransferase 2

susceptibility

DNA:polymorphism (human)

NCBI chr 8:17,606,445...17,623,397
Ensembl chr 8:14,575,455...14,576,327

G

neural cell adhesion molecule 1

disease_progression
severity

PMID:10374842 PMID:11249065

RGD:2326074 RGD:2326075

NCBI chr11:107,845,507...108,160,441
Ensembl chr11:111,925,677...112,000,401

G

NFKB inhibitor alpha

CTD Direct Evidence: therapeutic

NCBI chr14:16,155,331...16,158,588

G

nerve growth factor receptor

severity

mRNA:increased expression:tumor:associated with longer overall survival

NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966

G

nitric oxide synthase 2

disease_progression

protein:increased expression:pancreas

PMID:11196200 PMID:11687972 PMID:15165031

RGD:2325248 RGD:2325257 RGD:2325262

NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093

G

notch receptor 1

disease_progression

protein:increased expression:pancreas

NCBI chr 9:107,568,670...107,621,032
Ensembl chr 9:136,544,639...136,598,740

G

nuclear receptor subfamily 4 group A member 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:36,703,903...36,740,211
Ensembl chr12:37,480,300...37,501,188

G

nuclear receptor subfamily 5 group A member 2

CTD Direct Evidence: marker/mechanism

PMID:20101243 PMID:26098869

NCBI chr 1:175,625,140...175,775,955
Ensembl chr 1:179,934,573...180,083,607

G

neuropilin 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:33,298,918...33,456,466
Ensembl chr10:33,883,173...34,039,648

G

neurotrophic receptor tyrosine kinase 1

severity

mRNA:increased expression:tumor:associated with increased tumor aggressiveness

Ensembl chr 1:136,007,476...136,047,355

G

NUF2 component of NDC80 kinetochore complex

treatment

mRNA:increased expression:pancreas

PMID:25370920 PMID:26045769

RGD:11058437 RGD:28867232

NCBI chr 1:138,743,251...138,777,201
Ensembl chr 1:142,538,420...142,572,364

G

8-oxoguanine DNA glycosylase

disease_progression

DNA:polymorphism: :2657G>A (human)
DNA:polymorphism: :rs1052133 (human)

PMID:17230526 PMID:18559563

RGD:2317130 RGD:2317132

NCBI chr 3:9,702,311...9,742,283
Ensembl chr 3:9,940,955...9,947,335

G

partner and localizer of BRCA2

susceptibility

ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 1 | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3

PMID:100849 PMID:9536098 PMID:16199547 PMID:17200668 PMID:17200671 More...

NCBI chr16:14,470,367...14,507,841
Ensembl chr16:23,855,535...23,892,117

G

palladin, cytoskeletal associated protein

susceptibility

ClinVar Annotator: match by term: PALLD-related condition | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2
ClinVar Annotator: match by term: PALLD-related condition | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1

PMID:10454945 PMID:11474289 PMID:17194196 PMID:17415588 PMID:24033266 More...

NCBI chr 4:160,718,475...161,140,436

G

platelet derived growth factor receptor alpha

mRNA:increased expression:pancreas

PMID:7665222 PMID:14695158

RGD:2324850 RGD:2324851

NCBI chr 4:69,639,081...69,709,870
Ensembl chr 4:76,199,382...76,271,097

G

pancreatic and duodenal homeobox 1

CTD Direct Evidence: marker/mechanism

PMID:19077462 PMID:25086665 PMID:26098869

NCBI chr13:9,199,572...9,206,202

G

profilin 1

NCBI chr17:4,993,853...4,996,811
Ensembl chr17:4,981,765...4,985,022

G

plasminogen activator, urokinase

CTD Direct Evidence: marker/mechanism

NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136

G

DNA polymerase beta

disease_progression

DNA:polymorphisms: :165A>G, 2133T>C (human)

NCBI chr 8:41,582,370...41,615,950
Ensembl chr 8:39,026,991...39,060,464

G

peroxisome proliferator activated receptor delta

disease_progression

NCBI chr 6:34,903,798...34,987,208
Ensembl chr 6:36,003,988...36,081,132

G

peroxisome proliferator activated receptor gamma

susceptibility

DNA:polymorphism: :p.P12A (human)
CTD Direct Evidence: marker/mechanism|therapeutic

PMID:11034103 PMID:11741176 PMID:19152448 PMID:19436234

RGD:2317460 RGD:2317462

NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060

G

patched 1

CTD Direct Evidence: marker/mechanism
protein:increased expression:pancreas

PMID:19077462 PMID:19396459

NCBI chr 9:66,542,675...66,616,820
Ensembl chr 9:94,668,365...94,741,453

G

phosphatase and tensin homolog

CTD Direct Evidence: marker/mechanism

NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605

G

prostaglandin-endoperoxide synthase 2

susceptibility

mRNA, protein:increased expression:pancreas
DNA:SNPs: :-1195A > G, -765G > C (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphisms: :-1195A>A ,-765G>C (human)

PMID:10485483 PMID:10657949 PMID:15705899 PMID:16820089 PMID:19062735 More...

RGD:2317175 RGD:2317179 RGD:2317184 RGD:5135527

NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519

G

parathyroid hormone like hormone

CTD Direct Evidence: marker/mechanism

NCBI chr12:58,341,361...58,355,804
Ensembl chr12:60,960,071...60,973,750

G

RAB, member of RAS oncogene family like 3

susceptibility

ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 5 | ClinVar Annotator: match by term: RABL3-related condition

NCBI chr 3:117,794,224...117,850,184
Ensembl chr 3:124,707,984...124,748,983

G

RAD51 recombinase

protein:increased expression:pancreas (rat)

NCBI chr15:19,638,310...19,672,474
Ensembl chr15:37,891,056...37,925,207

G

RAD54 like

DNA:SNP:exon:rs1048771 (human)

NCBI chr 1:45,549,586...45,581,711
Ensembl chr 1:46,905,598...46,936,259

G

RAP1 GTPase activating protein

mRNA:decreased expression:pancreas (human)
CTD Direct Evidence: marker/mechanism

PMID:16424023 PMID:22614916

NCBI chr 1:20,790,076...20,860,511
Ensembl chr 1:21,754,733...21,824,405

G

RB transcriptional corepressor 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:29,453,872...29,624,665
Ensembl chr13:48,155,795...48,324,575

G

RecQ like helicase

DNA:SNP:3'utr:rs13035 (human)
DNA:SNPs:introns

PMID:16540687 PMID:18422747 PMID:19768149

RGD:2317365 RGD:2317369 RGD:2317370

NCBI chr12:64,796,383...64,829,165
Ensembl chr12:67,400,315...67,432,724

G

RELA proto-oncogene, NF-kB subunit

NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868

G

ret proto-oncogene

disease_progression

protein:increased expression:pancreas

NCBI chr10:40,050,396...40,103,629
Ensembl chr10:43,249,468...43,284,331

G

rhomboid domain containing 1

CTD Direct Evidence: therapeutic

NCBI chr2B:114,041,381...114,245,220
Ensembl chr2B:232,897,487...233,057,578

G

ribonucleotide reductase regulatory subunit M2

NCBI chr2A:10,119,508...10,128,318
Ensembl chr2A:10,275,598...10,284,640

G

RUNX family transcription factor 3

disease_progression

DNA:hypermethylation, loss of heterozygosity (human)

NCBI chr 1:24,097,321...24,164,065
Ensembl chr 1:25,073,134...25,137,335

G

retinoid X receptor alpha

NCBI chr 9:105,424,046...105,539,241
Ensembl chr 9:134,082,865...134,144,704

G

SEL1L adaptor subunit of SYVN1 ubiquitin ligase

NCBI chr14:62,050,695...62,111,489
Ensembl chr14:81,248,441...81,309,597

G

serpin family A member 1

disease_progression

NCBI chr14:75,001,714...75,014,214
Ensembl chr14:94,334,258...94,345,419

G

splicing factor 3b subunit 4

mRNA, protein:decreased expression:pancreas (human)

NCBI chr 1:125,268,113...125,273,405
Ensembl chr 1:128,924,317...128,929,610

G

SIN3-HDAC complex associated factor

CTD Direct Evidence: marker/mechanism

NCBI chr12:54,914,625...54,960,258
Ensembl chr12:57,498,428...57,544,489

G

solute carrier family 1 member 5

CTD Direct Evidence: marker/mechanism

NCBI chr19:43,765,001...43,778,981
Ensembl chr19:52,294,655...52,307,529

G

solute carrier family 29 member 1 (Augustine blood group)

CTD Direct Evidence: marker/mechanism

NCBI chr 6:43,815,006...43,830,290
Ensembl chr 6:45,099,243...45,113,689

G

solute carrier organic anion transporter family member 2B1

mRNA:decreased expression:pancreas (human)

NCBI chr11:70,211,124...70,266,513
Ensembl chr11:73,515,433...73,570,410

G

SMAD family member 2

mRNA:increased expression:pancreas (human)

NCBI chr18:41,213,001...41,309,902
Ensembl chr18:44,580,905...44,668,530

G

SMAD family member 3

DNA:mutations:exon

NCBI chr15:46,013,764...46,143,126
Ensembl chr15:64,284,949...64,414,185

G

SMAD family member 4

ClinVar Annotator: match by term: Cancer of the pancreas

NCBI chr18:44,402,112...44,456,779
Ensembl chr18:47,764,568...47,797,359

G

SMAD family member 7

mRNA:increased expression:pancreas (human)

NCBI chr18:42,306,324...42,337,214

G

smoothened, frizzled class receptor

treatment

protein:increased expression:pancreas

PMID:19396459 PMID:19460966 PMID:22859707

RGD:150340554 RGD:2324910 RGD:2324978

NCBI chr 7:121,143,968...121,168,873
Ensembl chr 7:133,668,304...133,693,048

G

synuclein gamma

NCBI chr10:83,383,566...83,391,064

G

SNW domain containing 1

susceptibility

DNA:snp:intron: T>A (human) (rs1477261)

NCBI chr14:58,271,830...58,315,773
Ensembl chr14:77,472,387...77,517,315

G

superoxide dismutase 1

protein:decreased expression:pancreas

NCBI chr21:18,029,831...18,037,526

G

superoxide dismutase 2

susceptibility
disease_progression

CTD Direct Evidence: marker/mechanism
DNA:polymorphism:cds:p.A16V (human)
protein:decreased expression:pancreas

PMID:11328670 PMID:12499913 PMID:12700280 PMID:17895890 PMID:18205184

RGD:1581235 RGD:2317406 RGD:2317410

NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960

G

serine peptidase inhibitor Kazal type 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:143,273,137...143,287,745

G

secreted phosphoprotein 1

NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935

G

somatostatin

CTD Direct Evidence: therapeutic

NCBI chr 3:184,695,561...184,697,091
Ensembl chr 3:193,155,363...193,158,337

G

somatostatin receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:18,968,969...18,973,560
Ensembl chr14:37,329,309...37,330,484

G

somatostatin receptor 2

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:15259086 PMID:17625444 PMID:19917848

NCBI chr17:67,093,013...67,099,086
Ensembl chr17:72,553,506...72,554,615

G

somatostatin receptor 3

CTD Direct Evidence: marker/mechanism

NCBI chr22:18,116,993...18,125,170
Ensembl chr22:35,954,232...35,955,488

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

PMID:22348037 PMID:23845849

NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067

G

serine/threonine kinase 11

Ensembl chr19:1,188,537...1,210,677

G

succinyl-CoA:glutarate-CoA transferase

CTD Direct Evidence: marker/mechanism

NCBI chr 7:43,381,156...44,100,614
Ensembl chr 7:43,421,615...44,139,738

G

synaptonemal complex protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:87,565,888...87,701,530
Ensembl chr 1:122,614,520...122,754,137

G

transcription factor 7 like 2

DNA:mutations:exon

NCBI chr10:109,541,524...109,759,499
Ensembl chr10:112,978,167...113,192,281

G

telomerase reverse transcriptase

CTD Direct Evidence: marker/mechanism

PMID:25086665 PMID:26098869

Ensembl chr 5:1,300,960...1,338,872

G

tissue factor pathway inhibitor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:85,835,141...85,839,515
Ensembl chr 7:99,426,006...99,431,099

G

transforming growth factor alpha

mRNA, protein:increased expression:pancreas

PMID:1401070 PMID:17785207

RGD:2317468 RGD:2317473

NCBI chr2A:70,510,727...70,617,628
Ensembl chr2A:71,625,196...71,731,461

G

transforming growth factor beta 1

disease_progression

CTD Direct Evidence: marker/mechanism
protein:increased expression:serum

PMID:16933058 PMID:18787407 PMID:23992306

RGD:2325015 RGD:2325018

NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973

G

transforming growth factor beta receptor 2

disease_progression

DNA:mutations:exon
protein:increased expresssion:pancreas
DNA:deletion, frameshift mutations (human)
mRNA:increased expresssion:pancreas

PMID:9365135 PMID:9850059 PMID:11866987 PMID:18772397

RGD:2317499 RGD:2317501 RGD:2317502 RGD:5490966

NCBI chr 3:30,536,187...30,623,653
Ensembl chr 3:30,854,460...30,938,856

G

transglutaminase 2

CTD Direct Evidence: marker/mechanism

NCBI chr20:34,450,845...34,488,106
Ensembl chr20:35,561,819...35,599,042

G

thrombospondin 1

disease_progression

DNA:hypermethylation (human)

PMID:10766168 PMID:16757110 PMID:20203415

RGD:2325021 RGD:2325023 RGD:2325028

NCBI chr15:18,521,802...18,538,172
Ensembl chr15:36,776,756...36,793,170

G

tumor necrosis factor

CTD Direct Evidence: therapeutic

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

G

TNF receptor superfamily member 10b

CTD Direct Evidence: therapeutic

NCBI chr 8:22,270,325...22,318,841
Ensembl chr 8:19,209,904...19,258,498

G

TNF superfamily member 10

CTD Direct Evidence: therapeutic

NCBI chr 3:169,512,491...169,530,706
Ensembl chr 3:177,694,021...177,712,137

G

tumor protein p53

CTD Direct Evidence: marker/mechanism
DNA:mutations:exon

PMID:18772397 PMID:23873029 PMID:26390243

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

G

tumor protein p53 binding protein 1

NCBI chr15:22,364,696...22,472,499
Ensembl chr15:40,519,012...40,626,741

G

tumor protein p63

CTD Direct Evidence: marker/mechanism

NCBI chr 3:186,651,879...186,918,300
Ensembl chr 3:195,199,167...195,474,104

G

TSC complex subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr16:615,776...655,411
Ensembl chr16:2,135,696...2,175,569

G

thymidine phosphorylase

CTD Direct Evidence: marker/mechanism

PMID:17443278 PMID:19671868

NCBI chr22:30,772,088...30,776,618

G

thymidylate synthetase

CTD Direct Evidence: marker/mechanism

NCBI chr18:13,653,085...13,668,478
Ensembl chr18:17,295,182...17,310,320

G

uridine-cytidine kinase 2

protein:increased expression:pancreatic neoplasm (human)

NCBI chr 1:141,259,057...141,343,122
Ensembl chr 1:145,110,434...145,131,894

G

vascular cell adhesion molecule 1

NCBI chr 1:103,377,815...103,395,118
Ensembl chr 1:102,091,336...102,107,732

G

vascular endothelial growth factor B

CTD Direct Evidence: marker/mechanism

NCBI chr11:59,591,750...59,595,926

G

von Hippel-Lindau tumor suppressor

associated with Hippel-Lindau Disease;DNA:missense mutation:exon:p.R238Q (human)
DNA:hypermethylation, deletion:promoter (human)

PMID:9488521 PMID:19690016

RGD:2325169 RGD:2325176

NCBI chr 3:10,077,630...10,089,499
Ensembl chr 3:10,430,143...10,440,234

G

Wnt family member 9A

DNA:mutations:exon

NCBI chr 1:203,320,990...203,350,599
Ensembl chr 1:208,300,609...208,327,191

G

WT1 transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr11:32,349,807...32,398,494
Ensembl chr11:32,238,720...32,287,249

G

XPC complex subunit, DNA damage recognition and repair factor

DNA:polymorphism:intron:AF076952 (human)

NCBI chr 3:14,063,499...14,097,023
Ensembl chr 3:14,403,958...14,437,377

G

exportin 1

exacerbates

protein:increased expression:pancreas (human)

NCBI chr2A:61,562,372...61,622,841
Ensembl chr2A:62,698,935...62,757,793

G

exportin 5

mRNA:decreased expression:pancreas (mouse)

NCBI chr 6:43,114,408...43,168,113
Ensembl chr 6:44,406,765...44,458,029

G

X-ray repair cross complementing 1

DNA:SNP:exon:rs1799782 (human)

NCBI chr19:40,485,052...40,522,188
Ensembl chr19:49,094,014...49,125,520

G

X-ray repair cross complementing 2

DNA:SNP:exon:rs3218536 (human)
DNA:polymorphism: :p.R188H (human)

PMID:16540687 PMID:17986315

RGD:2317365 RGD:2317507

NCBI chr 7:144,229,031...144,256,854
Ensembl chr 7:156,378,685...156,406,516

G

X-ray repair cross complementing 3

DNA:SNP:cd:rs861539 (human)

NCBI chr14:84,323,644...84,341,763
Ensembl chr14:104,131,903...104,149,037

G

zinc and ring finger 3

CTD Direct Evidence: marker/mechanism

PMID:25086665 PMID:26098869

NCBI chr22:9,891,021...10,109,147
Ensembl chr22:27,742,301...27,810,427

pancreatic carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activin A receptor type 1B

ClinVar Annotator: match by term: Carcinoma of pancreas

NCBI chr12:36,765,655...36,811,355
Ensembl chr12:37,541,867...37,566,660

G

ATM serine/threonine kinase

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:988733 PMID:1849795 PMID:3338800 PMID:8808599 PMID:9443866 More...

NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041

G

BRCA1 DNA repair associated

ClinVar Annotator: match by term: Carcinoma of head of pancreas | ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:9150174 PMID:10667592 PMID:10667595 PMID:11802209 PMID:12566964 More...

NCBI chr17:14,197,946...14,279,064
Ensembl chr17:14,428,526...14,506,815

G

BRCA2 DNA repair associated

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8665505 PMID:9150150 PMID:9361038 PMID:9536098 PMID:9585613 More...

NCBI chr13:13,574,422...13,658,967
Ensembl chr13:32,010,066...32,091,332

G

BRCA1 interacting DNA helicase 1

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:16116423 PMID:17033622 PMID:21964575 PMID:25330149 PMID:25741868 More...

NCBI chr17:55,786,568...55,973,366
Ensembl chr17:60,901,073...61,083,462

G

chromosome 9 C11orf65 homolog

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:988733 PMID:1849795 PMID:3338800 PMID:8808599 PMID:9443866 More...

NCBI chr11:103,195,244...103,352,211
Ensembl chr11:106,670,277...106,817,886

G

carbonyl reductase 4

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:17194196 PMID:25741868 PMID:28492532

NCBI chr 4:161,103,477...161,235,840
Ensembl chr 4:173,282,162...173,309,905

G

cyclin dependent kinase inhibitor 1A

NCBI chr 6:36,241,405...36,250,032
Ensembl chr 6:37,436,990...37,445,599

G

cyclin dependent kinase inhibitor 2A

susceptibility

DNA:insertion:cds:p.R112_L113insR (human)

NCBI chr 9:21,803,862...21,831,322

G

chromodomain helicase DNA binding protein 3

disease_progression

protein:increased expression:pancreas

NCBI chr17:7,919,803...7,947,787
Ensembl chr17:7,910,644...7,933,115

G

checkpoint kinase 2

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:9536098 PMID:10617473 PMID:11053450 PMID:11479205 PMID:11719428 More...

NCBI chr22:9,757,038...9,811,171

G

ERCC excision repair 4, endonuclease catalytic subunit

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8797827 PMID:9579555 PMID:20221251 PMID:21228398 PMID:21612988 More...

NCBI chr16:12,848,334...12,880,480
Ensembl chr16:14,272,417...14,304,496

G

FA complementation group E

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:11001585 PMID:17924555 PMID:21279724 PMID:25741868 PMID:26822949 More...

NCBI chr 6:35,012,076...35,027,018

G

FA complementation group G

ClinVar Annotator: match by term: Carcinoma of pancreas

NCBI chr 9:34,924,399...34,931,077
Ensembl chr 9:35,730,176...35,736,648

G

heterogeneous nuclear ribonucleoprotein A2/B1

severity

protein:increased expression:pancreas (rat)

NCBI chr 7:26,835,881...26,846,578
Ensembl chr 7:26,439,443...26,449,985

G

homeobox B13

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8756292 PMID:15964834 PMID:17138648 PMID:22236224 PMID:22714738 More...

NCBI chr17:8,807,988...8,810,362
Ensembl chr17:8,994,224...8,996,598

G

kinase insert domain receptor

treatment

NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:1875403 PMID:7773929 PMID:8439212 PMID:12110640 PMID:12720172 More...

NCBI chr12:61,062,689...61,108,524
Ensembl chr12:63,679,293...63,724,335

G

mechanistic target of rapamycin kinase

treatment

NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841

G

MYC proto-oncogene, bHLH transcription factor

OMIM:260350

NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863

G

nibrin

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:9590180 PMID:9590181 PMID:9620777 PMID:10398434 PMID:10799436 More...

NCBI chr 8:86,622,797...86,674,202
Ensembl chr 8:88,575,198...88,626,307

G

partner and localizer of BRCA2

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:17200668 PMID:17200671 PMID:17200672 PMID:20122277 PMID:20412113 More...

NCBI chr16:14,470,367...14,507,841
Ensembl chr16:23,855,535...23,892,117

G

palladin, cytoskeletal associated protein

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:17194196 PMID:25741868 PMID:28492532

NCBI chr 4:160,718,475...161,140,436

G

DNA polymerase delta 1, catalytic subunit

ClinVar Annotator: match by term: Carcinoma of pancreas

NCBI chr19:47,347,919...47,381,772
Ensembl chr19:56,251,356...56,297,611

G

Raf-1 proto-oncogene, serine/threonine kinase

mRNA:increased expression:pancreas (rat)

NCBI chr 3:12,510,084...12,590,598
Ensembl chr 3:12,853,415...12,932,871

G

RB binding protein 8, endonuclease

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:9811458 PMID:28492532

NCBI chr18:16,181,652...16,274,597
Ensembl chr18:19,811,989...19,903,522

G

SMAD family member 4

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8653691 PMID:9582123 PMID:9811934 PMID:10398437 PMID:10764709 More...

NCBI chr18:44,402,112...44,456,779
Ensembl chr18:47,764,568...47,797,359

G

serine/threonine kinase 11

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:10362809 PMID:11430832 PMID:15188174 PMID:15800014 PMID:16287113 More...

Ensembl chr19:1,188,537...1,210,677

G

tumor protein p53

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:1565143 PMID:1565144 PMID:1581912 PMID:1591732 PMID:1631137 More...

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

G

TSC complex subunit 1

NCBI chr 9:104,007,708...104,060,938
Ensembl chr 9:132,638,003...132,675,759

pancreatic ductal adenocarcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

anterior gradient 2, protein disulphide isomerase family member

protein:increased expression:pancreas

NCBI chr 7:17,446,275...17,489,802
Ensembl chr 7:16,773,281...16,785,879

G

calreticulin

ameliorates

human cells in mouse model
human cells in a mouse model

PMID:29072694 PMID:33028359

RGD:150520160 RGD:150521706

NCBI chr19:12,501,013...12,506,909
Ensembl chr19:13,242,900...13,249,416

G

cyclin D1

severity

protein:increased expression:pancreas (human)
DNA:snp:exon:c.870G>A (human)

PMID:22939953 PMID:25470788

RGD:13462050 RGD:13462062

NCBI chr11:64,737,006...64,750,353

G

CD59 molecule (CD59 blood group)

disease_progression

protein:increased expression:blood (human)

NCBI chr11:33,680,580...33,708,479
Ensembl chr11:33,552,164...33,590,157

G

cyclin dependent kinase 4

severity

protein:increased expression:pancreas, islet of Langerhans (human)

NCBI chr12:31,174,446...31,178,597
Ensembl chr12:31,434,594...31,438,876

G

E2F transcription factor 1

severity

protein:increased expression:pancreatic ductal cell, nucleus (human)
DNA:amplification: : (human)

PMID:12650514 PMID:17233815 PMID:27573434

RGD:13838735 RGD:13838738 RGD:13838739

NCBI chr20:29,963,083...29,973,860
Ensembl chr20:31,103,764...31,110,604

G

forkhead box M1

disease_progression

NCBI chr12:2,978,400...2,999,077
Ensembl chr12:2,910,028...2,930,503

G

far upstream element binding protein 1

mRNA:increased expression:pancreatic duct (human)

NCBI chr 1:77,162,675...77,198,486

G

GLI pathogenesis related 2

disease_progression

protein:decreased expression:blood (human)

NCBI chr 9:35,986,341...36,013,662
Ensembl chr 9:36,787,649...36,814,812

G

glutamic-oxaloacetic transaminase 1

treatment

human cells in a mouse model

NCBI chr10:96,012,345...96,046,266
Ensembl chr10:99,506,205...99,540,178

G

heat shock protein family A (Hsp70) member 8

disease_progression

protein:decreased expression:blood (human)

NCBI chr11:117,890,545...117,895,262
Ensembl chr11:121,809,800...121,815,773

G

inhibitor of nuclear factor kappa B kinase subunit beta

susceptibility

NCBI chr 8:41,515,613...41,576,229
Ensembl chr 8:38,960,594...39,020,971

G

Janus kinase 1

mRNA:decreased expression:pancreatic ductal cell (human)

NCBI chr 1:64,083,562...64,315,909
Ensembl chr 1:65,973,904...66,024,991

G

aflatoxin B1 aldehyde reductase member 2

protein:increased expression:pancreas

NCBI chr 1:18,262,631...18,270,783
Ensembl chr 1:19,309,471...19,317,227

G

complement factor H-related protein 3

disease_progression

protein:decreased expression:blood (human)

NCBI chr 1:172,355,204...172,389,914

G

mitogen-activated protein kinase 8

disease_progression
severity

protein:increased phosphorylation:pancreas (mouse)

PMID:23237571 PMID:28837246

RGD:14348974 RGD:14348975

NCBI chr10:45,806,748...45,936,362

G

placental growth factor

severity

associated with obesity

NCBI chr14:55,494,152...55,508,066
Ensembl chr14:74,338,976...74,352,964

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

mRNA, protein:increased expression:pancreas (human)

NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614

G

phosphoinositide-3-kinase regulatory subunit 2

severity

human cells in a mouse model

NCBI chr19:17,632,265...17,649,664
Ensembl chr19:18,611,179...18,624,177

G

phospholipase D1

severity

protein:increased expression:pancreas (human)

NCBI chr 3:168,606,342...168,816,383
Ensembl chr 3:176,790,753...176,961,033

G

protein tyrosine phosphatase receptor type B

disease_progression

protein:decreased expression:blood (human)

NCBI chr12:68,025,973...68,147,613
Ensembl chr12:70,797,843...70,915,308

G

protein tyrosine phosphatase receptor type M

disease_progression

protein:decreased expression:blood (human)

NCBI chr18:5,879,556...6,706,824
Ensembl chr18:8,206,677...9,030,286

G

Rac family small GTPase 1

mRNA, protein:increased expression:pancreas (mouse)
mRNA:increased expression:pancreas (human)

PMID:21684285 PMID:23334332

RGD:14392806 RGD:14392816

NCBI chr 7:7,039,379...7,068,866

G

RAS like proto-oncogene A

mRNA:increased expression:pancreas (human)

NCBI chr 7:44,528,146...44,611,431
Ensembl chr 7:44,559,380...44,580,495

G

S100 calcium binding protein A8

disease_progression

protein:increased expression:blood (human)

NCBI chr 1:128,741,378...128,742,520
Ensembl chr 1:132,370,435...132,371,591

G

SMAD family member 2

severity

NCBI chr18:41,213,001...41,309,902
Ensembl chr18:44,580,905...44,668,530

G

transforming growth factor beta 1

ameliorates

protein:decreased expression:pancreas (human)

NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973

G

transforming growth factor beta 2

ameliorates

protein:decreased expression:pancreas (human)

NCBI chr 1:193,907,398...194,005,800
Ensembl chr 1:198,758,751...198,859,041

G

transforming growth factor beta 3

ameliorates

protein:decreased expression:pancreas (human)

NCBI chr14:56,516,697...56,542,097
Ensembl chr14:75,359,505...75,382,412

G

transforming growth factor beta receptor 1

ameliorates

human cell line in a mouse model

NCBI chr 9:70,195,007...70,243,514
Ensembl chr 9:98,332,739...98,362,748

G

vascular endothelial growth factor D

protein:increased expression:blood serum (human)

NCBI chr X:7,972,227...8,011,263
Ensembl chr X:15,254,945...15,293,704

G

vanin 1

disease_progression

protein:increased expression:blood (human)

NCBI chr 6:130,459,268...130,491,167
Ensembl chr 6:134,566,117...134,598,784

pancreatic ductal carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

mRNA, protein:increased expression:pancreas

NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853

G

angiotensin converting enzyme 2

protein:decreased expression:pancreas

NCBI chr X:8,189,267...8,229,415
Ensembl chr X:15,470,896...15,510,891

G

ADAM metallopeptidase domain 8

disease_progression

mRNA:increased expression:pancreas

Ensembl chr10:134,172,724...134,186,227

G

ADAM metallopeptidase domain 9

disease_progression

protein:altered localization:cytoplasm

NCBI chr 8:38,298,194...38,406,706
Ensembl chr 8:35,473,278...35,581,192

G

anterior gradient 2, protein disulphide isomerase family member

mRNA:increased expression:pancreas

NCBI chr 7:17,446,275...17,489,802
Ensembl chr 7:16,773,281...16,785,879

G

angiotensin II receptor type 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380

G

albumin

disease_progression

NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418

G

annexin A2

disease_progression

mRNA, protein:increased expression, altered localization:pancreas, plasma membrane

PMID:16450333 PMID:19260470

RGD:2317307 RGD:2325731

NCBI chr15:39,322,303...39,371,565
Ensembl chr15:57,625,425...57,674,250

G

annexin A5

protein:increased expression:pancreas

NCBI chr 4:113,868,218...113,897,243
Ensembl chr 4:125,006,038...125,034,972

G

apolipoprotein C1

G

arginase 2

CTD Direct Evidence: marker/mechanism

NCBI chr14:48,197,831...48,231,829
Ensembl chr14:67,075,941...67,109,962

G

BMI1 proto-oncogene, polycomb ring finger

protein:increased expression:pancreas
protein:increased expression:exocrine pancreas:

NCBI chr10:22,477,755...22,487,894
Ensembl chr10:22,857,776...22,863,479

G

chromosome 20 C19orf33 homolog

CTD Direct Evidence: marker/mechanism

NCBI chr19:35,395,222...35,396,580
Ensembl chr19:43,969,247...43,970,601

G

calreticulin

protein:increased expression:pancreatic duct

NCBI chr19:12,501,013...12,506,909
Ensembl chr19:13,242,900...13,249,416

G

chromobox 7

disease_progression

protein:decreased expression:pancreas

NCBI chr22:20,037,529...20,059,459
Ensembl chr22:37,854,056...37,876,084

G

cholecystokinin A receptor

protein:decreased expression:pancreas
mRNA:increased expression:pancreatic duct

PMID:9239407 PMID:12851875

RGD:4110816 RGD:4110818

NCBI chr 4:20,881,340...20,890,986
Ensembl chr 4:26,157,702...26,166,773

G

cholecystokinin B receptor

protein:decreased expression:pancreas

NCBI chr11:6,393,435...6,405,821
Ensembl chr11:6,075,816...6,088,145

G

cyclin D1

severity

protein:increased expression:pancreas (human)

NCBI chr11:64,737,006...64,750,353

G

CD40 molecule

treatment

protein:increased expression:dendritic cell

PMID:20976171 PMID:21436454 PMID:23983255

RGD:11522743 RGD:5490301 RGD:5490524

NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994

G

cyclin dependent kinase 6

treatment

human cells in a mouse model

NCBI chr 7:84,603,419...84,835,082

G

cyclin dependent kinase inhibitor 1A

disease_progression

NCBI chr 6:36,241,405...36,250,032
Ensembl chr 6:37,436,990...37,445,599

G

cyclin dependent kinase inhibitor 2A

CTD Direct Evidence: marker/mechanism

NCBI chr 9:21,803,862...21,831,322

G

claudin 4

Ensembl chr 7:80,983,832...80,984,461

G

C-X-C motif chemokine ligand 11

CTD Direct Evidence: marker/mechanism

NCBI chr 4:48,169,954...48,172,455
Ensembl chr 4:54,007,818...54,010,336

G

DNA methyltransferase 1

disease_progression

CTD Direct Evidence: marker/mechanism
protein:increased expression:pancreas

PMID:19424621 PMID:29844410

NCBI chr19:9,681,847...9,745,334
Ensembl chr19:10,342,478...10,406,972

G

DNA methyltransferase 3 beta

disease_progression

NCBI chr20:29,049,993...29,096,957
Ensembl chr20:30,186,069...30,215,487

G

deltex E3 ubiquitin ligase 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:110,661,247...110,702,780
Ensembl chr12:114,046,700...114,085,372

G

deltex E3 ubiquitin ligase 4

CTD Direct Evidence: marker/mechanism

NCBI chr11:54,389,228...54,425,655
Ensembl chr11:57,839,228...57,874,337

G

epidermal growth factor

disease_progression

protein:increased expression: :

NCBI chr 4:102,410,724...102,509,691
Ensembl chr 4:112,977,565...113,076,460

G

Fas ligand

protein:increased expression:pancreas, liver

PMID:10547193 PMID:15375495

RGD:2317741 RGD:2317747

NCBI chr 1:148,159,826...148,167,785
Ensembl chr 1:151,868,430...151,876,281

G

fibroblast growth factor 2

disease_progression

PMID:12717266 PMID:18704599

RGD:2317756 RGD:2317758

NCBI chr 4:115,005,136...115,076,369
Ensembl chr 4:126,149,813...126,214,942

G

fascin actin-bundling protein 1

disease_progression

protein:increased expression:pancreas

NCBI chr 7:5,848,902...5,862,756

G

glycoprotein nmb

CTD Direct Evidence: marker/mechanism

NCBI chr 7:23,931,220...23,959,687
Ensembl chr 7:23,539,928...23,568,624

G

glutathione S-transferase pi 1

resistance

DNA:methylation: :
mRNA, protein:increased expression:pancreas

PMID:12488200 PMID:16537562 PMID:17265526

RGD:2317806 RGD:2317809 RGD:2317811

NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472

G

histone deacetylase 1

disease_progression

protein:increased expression:pancreas

NCBI chr 1:31,578,373...31,619,970
Ensembl chr 1:32,585,791...32,626,410

G

HEAT repeat containing 1

treatment

NCBI chr 1:212,110,229...212,164,299
Ensembl chr 1:217,109,359...217,164,791

G

hes family bHLH transcription factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:191,432,513...191,435,387
Ensembl chr 3:201,749,044...201,754,257

G

hes related family bHLH transcription factor with YRPW motif 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:76,286,433...76,290,507
Ensembl chr 8:77,913,761...77,921,201

G

hes related family bHLH transcription factor with YRPW motif 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:123,527,180...123,538,794
Ensembl chr 6:127,647,547...127,659,056

G

heat shock protein family A (Hsp70) member 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 6:31,476,710...31,491,411

G

heat shock protein family A (Hsp70) member 1B

CTD Direct Evidence: marker/mechanism

NCBI chr 6:31,488,882...31,491,412

G

insulin like growth factor 1

NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177

G

insulin like growth factor 1 receptor

protein:increased expression:pancreas

PMID:14506643 PMID:14627343

RGD:2317649 RGD:2317652

NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974

G

interleukin 4

NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581

G

interleukin 4 receptor

protein:increased expression:pancreas

Ensembl chr16:27,642,702...27,737,445

G

insulin

Glucagon/insulin

NCBI chr11:2,200,785...2,202,579
Ensembl chr11:2,218,117...2,231,666

G

jagged canonical Notch ligand 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:10,582,234...10,618,507
Ensembl chr20:10,582,094...10,618,383

G

jagged canonical Notch ligand 2

CTD Direct Evidence: marker/mechanism

NCBI chr14:85,785,586...85,812,056
Ensembl chr14:105,569,837...105,585,878

G

lysine demethylase 2B

severity

mRNA, protein:increased expression:pancreas (human)

NCBI chr12:119,027,633...119,183,779
Ensembl chr12:122,401,296...122,555,246

G

KIT ligand

CTD Direct Evidence: marker/mechanism

NCBI chr12:86,036,501...86,124,274
Ensembl chr12:89,341,921...89,436,758

G

KRAS proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism

PMID:25347530 PMID:30654191

NCBI chr12:61,062,689...61,108,524
Ensembl chr12:63,679,293...63,724,335

G

keratin 7

disease_progression

NCBI chr12:36,514,021...36,529,721
Ensembl chr12:37,291,244...37,307,341

G

L1 cell adhesion molecule

severity

protein:increased expression:pancreas (human)

NCBI chr X:143,412,303...143,437,090
Ensembl chr X:153,298,690...153,324,228

G

mitogen-activated protein kinase kinase kinase 7

CTD Direct Evidence: marker/mechanism

NCBI chr 6:88,398,329...88,470,926
Ensembl chr 6:91,664,263...91,737,468

G

mitogen-activated protein kinase 3

treatment

human cells in mouse model

Ensembl chr16:30,489,362...30,498,017

G

minichromosome maintenance complex component 7

mRNA, protein:increased expression:pancreatic duct

NCBI chr 7:92,128,037...92,136,976
Ensembl chr 7:105,561,591...105,570,720

G

MDM2 proto-oncogene

severity
onset

protein:increased expression:pancreas (human)
DNA:snp:promoter, intron:IVS1+309T>G (human)

PMID:15810085 PMID:19752772

RGD:2317414 RGD:2317416

NCBI chr12:66,322,340...66,357,010
Ensembl chr12:69,102,084...69,133,278

G

menin 1

NCBI chr11:60,159,009...60,166,222
Ensembl chr11:63,499,962...63,507,164

G

MET proto-oncogene, receptor tyrosine kinase

protein:increased expression:pancreatic duct (human)

NCBI chr 7:108,646,278...108,772,238
Ensembl chr 7:121,365,438...121,468,159

G

O-6-methylguanine-DNA methyltransferase

susceptibility

protein:increased activity, increased expression:ductal adenocarcinoma (human)
DNA:missense mutation:cds:p.L84F rs12917 (human)

PMID:9393761 PMID:16844323

RGD:2317648 RGD:2317664

NCBI chr10:126,059,701...126,365,850
Ensembl chr10:130,305,485...130,609,422

G

matrix metallopeptidase 2

severity

protein:increased expression:pancreas

NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279

G

matrix metallopeptidase 9

protein:increased expression:blood
protein:increased expression:pancreas, serum

PMID:18706098 PMID:20332475

RGD:2325830 RGD:2325844

NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129

G

mesothelin

disease_progression

protein:increased secretion:serum
CTD Direct Evidence: marker/mechanism
DNA:hypomethylation:5'UTR

PMID:12874021 PMID:14576474 PMID:19818733 PMID:21775916 PMID:25347530

RGD:2326055 RGD:2326065

Ensembl chr16:777,146...783,449

G

mucin 1, cell surface associated

disease_progression

protein:increased expression, altered localization:pancreas

PMID:14681945 PMID:18713982 PMID:19109152

RGD:2317983 RGD:2324616 RGD:2324633

NCBI chr 1:130,533,508...130,537,866
Ensembl chr 1:134,141,969...134,145,850

G

mucin 3A, cell surface associated

disease_progression

mRNA:increased expression:pancreas

NCBI chr 7:92,974,006...92,993,990

G

mucin 4, cell surface associated

disease_progression

protein:increased expression:pancreas
mRNA:increased expression:pancreas

PMID:12657964 PMID:16049287

RGD:2324942 RGD:2324946

NCBI chr 3:193,050,895...193,114,931

G

mucin 5AC, oligomeric mucus/gel-forming

disease_progression

mRNA:increased expression:pancreas

PMID:7657125 PMID:10227724

RGD:2324907 RGD:2324986

NCBI chr11:1,191,223...1,234,373

G

mucin 5B, oligomeric mucus/gel-forming

mRNA:increased expression:pancreas

G

N-myc downstream regulated 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:129,891,918...129,952,489
Ensembl chr 8:132,866,245...132,926,514

G

NFE2 like bZIP transcription factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085

G

NME/NM23 nucleoside diphosphate kinase 1

protein:increased expression:pancreas (human)

NCBI chr17:45,243,588...45,252,135
Ensembl chr17:50,113,622...50,131,636

G

nitric oxide synthase 2

NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093

G

notch receptor 1

CTD Direct Evidence: marker/mechanism

PMID:19028876 PMID:19208345 PMID:20484026

RGD:2325323 RGD:2325324

NCBI chr 9:107,568,670...107,621,032
Ensembl chr 9:136,544,639...136,598,740

G

notch receptor 3

CTD Direct Evidence: marker/mechanism

NCBI chr19:14,692,571...14,733,758
Ensembl chr19:15,678,674...15,715,080

G

notch receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 6:31,842,233...31,871,412
Ensembl chr 6:32,722,112...32,750,978

G

neurotrophic receptor tyrosine kinase 3

disease_progression

protein:increased expression:pancreas

PMID:10209957 PMID:11295066

RGD:2325660 RGD:2325663

NCBI chr15:66,566,219...66,953,279
Ensembl chr15:85,776,832...86,157,204

G

oncostatin M

CTD Direct Evidence: marker/mechanism

NCBI chr22:11,298,965...11,303,009
Ensembl chr22:29,101,085...29,105,081

G

palladin, cytoskeletal associated protein

protein:increased expression, alternative form:pancreas, fibroblast

NCBI chr 4:160,718,475...161,140,436

G

paired box 6

protein:increased expression:pancreatic duct (human)

NCBI chr11:31,753,190...31,782,225
Ensembl chr11:31,641,813...31,664,474

G

PMS1 homolog 1, mismatch repair system component

protein:increased expression:pancreatic duct

NCBI chr2B:77,090,215...77,180,724
Ensembl chr2B:195,010,233...195,100,492

G

peroxisome proliferator activated receptor gamma

disease_progression

NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060

G

prostaglandin-endoperoxide synthase 2

NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519

G

RELA proto-oncogene, NF-kB subunit

CTD Direct Evidence: marker/mechanism

NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868

G

ring finger protein 2

protein:increased expression:pancreas

NCBI chr 1:160,568,438...160,626,783
Ensembl chr 1:164,721,458...164,779,420

G

retinoid X receptor alpha

severity

NCBI chr 9:105,424,046...105,539,241
Ensembl chr 9:134,082,865...134,144,704

G

serpin family A member 1

mRNA, protein:increased expression:pancreas

NCBI chr14:75,001,714...75,014,214
Ensembl chr14:94,334,258...94,345,419

G

solute carrier family 2 member 2

protein:increased expression:pancreatic duct

NCBI chr 3:168,002,609...168,033,237
Ensembl chr 3:176,188,184...176,218,722

G

SMAD family member 4

disease_progression

NCBI chr18:44,402,112...44,456,779
Ensembl chr18:47,764,568...47,797,359

G

smoothened, frizzled class receptor

NCBI chr 7:121,143,968...121,168,873
Ensembl chr 7:133,668,304...133,693,048

G

serine/threonine kinase 11

CTD Direct Evidence: marker/mechanism

Ensembl chr19:1,188,537...1,210,677

G

transforming growth factor beta 1

disease_progression

NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973

G

transforming growth factor beta receptor 2

disease_progression

mRNA:increased expresssion:pancreas

PMID:10547197 PMID:17114585

RGD:2317498 RGD:2317500

NCBI chr 3:30,536,187...30,623,653
Ensembl chr 3:30,854,460...30,938,856

G

thrombospondin 1

disease_progression

DNA:hypermethylation:promoter (human)

PMID:12429967 PMID:19065635

RGD:2325022 RGD:2325025

NCBI chr15:18,521,802...18,538,172
Ensembl chr15:36,776,756...36,793,170

G

transmembrane serine protease 3

NCBI chr21:28,679,488...28,703,313
Ensembl chr21:41,997,642...42,022,740

G

tumor protein p53

CTD Direct Evidence: marker/mechanism

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

G

TSC complex subunit 2

severity

NCBI chr16:615,776...655,411
Ensembl chr16:2,135,696...2,175,569

G

thymidine phosphorylase

disease_progression

NCBI chr22:30,772,088...30,776,618

G

vascular endothelial growth factor A

CTD Direct Evidence: marker/mechanism

NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353

G

von Hippel-Lindau tumor suppressor

DNA:hypermethylation:promoter (human)

NCBI chr 3:10,077,630...10,089,499
Ensembl chr 3:10,430,143...10,440,234

G

YEATS domain containing 2

CTD Direct Evidence: marker/mechanism

NCBI chr 3:180,736,213...180,847,545
Ensembl chr 3:188,903,615...189,016,942

G

zinc finger ZZ-type containing 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:76,783,387...76,902,711
Ensembl chr 1:78,866,284...78,986,872

pancreatic endocrine carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BRCA2 DNA repair associated

ClinVar Annotator: match by term: Neuroendocrine tumor of pancreas

PMID:15145354 PMID:22762150 PMID:25741868 PMID:29446198

NCBI chr13:13,574,422...13,658,967
Ensembl chr13:32,010,066...32,091,332

G

cut like homeobox 1

exacerbates

protein:increased expression:pancreas (human)

NCBI chr 7:93,954,599...94,432,697
Ensembl chr 7:107,191,124...107,609,940

G

death domain associated protein

disease_progression

DNA:frameshift, frameshift mutations, nonsense mutation, missense mutations:CDS:multiple (human)

NCBI chr 6:32,890,846...32,895,307
Ensembl chr 6:34,004,543...34,008,717

G

O-6-methylguanine-DNA methyltransferase

DNA:hypermethylation:promoter (human)

NCBI chr10:126,059,701...126,365,850
Ensembl chr10:130,305,485...130,609,422

G

partner and localizer of BRCA2

ClinVar Annotator: match by term: Neuroendocrine tumor of pancreas

PMID:17200668 PMID:17200671 PMID:17200672 PMID:24136930 PMID:25099575 More...

NCBI chr16:14,470,367...14,507,841
Ensembl chr16:23,855,535...23,892,117

G

placental growth factor

treatment
disease_progression

human cells in a mouse model
protein:increased expression:serum (human)

PMID:23463017 PMID:26861455

RGD:14349029 RGD:14349030

NCBI chr14:55,494,152...55,508,066
Ensembl chr14:74,338,976...74,352,964

pancreatic intraductal papillary-mucinous neoplasm

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

DNA:missense mutation:cds:p.E17K (human)

NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756

G

tumor protein p53

DNA:missense mutations: :multiple

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

G

vascular endothelial growth factor D

protein:increased expression:blood serum (human)

NCBI chr X:7,972,227...8,011,263
Ensembl chr X:15,254,945...15,293,704

Pancreatic Intraepithelial Neoplasia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

anterior gradient 2, protein disulphide isomerase family member

protein:increased expression:pancreas

NCBI chr 7:17,446,275...17,489,802
Ensembl chr 7:16,773,281...16,785,879

G

BMI1 proto-oncogene, polycomb ring finger

protein:increased expression:pancreatic acinar cell:
protein:increased expression:exocrine pancreas:

NCBI chr10:22,477,755...22,487,894
Ensembl chr10:22,857,776...22,863,479

G

chromobox 7

disease_progression

protein:decreased expression:pancreas

NCBI chr22:20,037,529...20,059,459
Ensembl chr22:37,854,056...37,876,084

G

cyclin D1

disease_progression

protein:increased expression:pancreas (human)

PMID:11751405 PMID:12882690

RGD:13462061 RGD:13464129

NCBI chr11:64,737,006...64,750,353

G

DNA methyltransferase 1

protein:increased expression:pancreas

NCBI chr19:9,681,847...9,745,334
Ensembl chr19:10,342,478...10,406,972

G

histone deacetylase 1

protein:increased expression:pancreas

NCBI chr 1:31,578,373...31,619,970
Ensembl chr 1:32,585,791...32,626,410

G

inhibitor of nuclear factor kappa B kinase subunit beta

severity
disease_progression

PMID:22056382 PMID:22406536

RGD:13838740 RGD:13838742

NCBI chr 8:41,515,613...41,576,229
Ensembl chr 8:38,960,594...39,020,971

pancreatic mucinous cystadenoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

KRAS proto-oncogene, GTPase

severity

DNA:mutations:cds:

NCBI chr12:61,062,689...61,108,524
Ensembl chr12:63,679,293...63,724,335

pancreatic solid pseudopapillary carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin D1

severity

protein:increased expression:pancreas (human)

NCBI chr11:64,737,006...64,750,353

vipoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

menin 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:60,159,009...60,166,222
Ensembl chr11:63,499,962...63,507,164

G

somatostatin

CTD Direct Evidence: therapeutic

NCBI chr 3:184,695,561...184,697,091
Ensembl chr 3:193,155,363...193,158,337

Term paths to the root

Path 1
Term	Annotations
disease	15835
disease of anatomical entity	15491
endocrine system disease	6240
pancreas disease	933
Pancreatic Neoplasms	405
Pancreatic Benign Neoplasm +	14
islet cell tumor +	28
pancreatic cancer +	402

paths to the root