Pancreatic Neoplasms - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Pancreatic Neoplasms	go back to main search page
Accession:	DOID:9003100	browse the term
Synonyms:	exact_synonym:	Pancreas Neoplasms; pancreas neoplasm; pancreatic neoplasm
	narrow_synonym:	Borderline Exocrine Pancreatic Neoplasm
	xref:	EFO:0003860; EFO:1000133; NCI:C34035

show annotations for term's descendants Sort by:
Rat (483) Mouse (506) Human (3225) Chinchilla (383) Bonobo (405) Dog (401) Squirrel (391) Pig (395) Green Monkey (398) Naked Mole-rat (380) All
Genes (424) Cell Lines (59)

Adult Pancreatic Cancer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

duodenal gastrinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

menin 1

associated with Neuroendocrine Tumors; DNA:loss of heterozygosity: :

RGD

NCBI chr 1:213,068,166...213,074,132
Ensembl chr 1:203,639,000...203,644,871

Familial Pancreatic Carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apolipoprotein A4

mRNA:increased expression:pancreas, carcinoma (human)

RGD

NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:46,539,082...46,541,469

G

ATM serine/threonine kinase

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:8755918 PMID:9443866 PMID:9463314 PMID:9887333 PMID:10330348 More...

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437

G

BRCA1 associated RING domain 1

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:25085752 PMID:25741868 PMID:26315354 PMID:26467025 PMID:26787654 More...

NCBI chr 9:80,069,960...80,144,167
Ensembl chr 9:72,623,155...72,694,265

G

similar to human chromosome 11 open reading frame 65

ClinVar Annotator: match by term: Familial pancreatic carcinoma

NCBI chr 8:62,692,123...62,720,951
Ensembl chr 8:53,796,366...53,824,748

G

cyclin-dependent kinase inhibitor 2A

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:7640518 PMID:7647780 PMID:7987387 PMID:8668202 PMID:9823374 More...

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:1875403 PMID:2547513 PMID:3627975 PMID:7773929 PMID:8439212 More...

NCBI chr 4:179,916,255...179,949,613

G

SMAD family member 4

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:25741868 PMID:26467025 PMID:26900293 PMID:27611364 PMID:28283864 More...

NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438

G

tumor protein p53

ClinVar Annotator: match by term: Familial pancreatic carcinoma

PMID:1565143 PMID:1565144 PMID:1631137 PMID:1683921 PMID:1978757 More...

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

gastrinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

insulin-like growth factor 1 receptor

mRNA and protein: increased expression::poor prognosis for high expression

RGD

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777

G

menin 1

DNA:mutations: :
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17961653 PMID:15944766

NCBI chr 1:213,068,166...213,074,132
Ensembl chr 1:203,639,000...203,644,871

G

MET proto-oncogene, receptor tyrosine kinase

severity

associated with Zollinger-Ellison Syndrome; mRNA:increased expression:tumor (human)

RGD

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876

G

O-6-methylguanine-DNA methyltransferase

DNA:hypomethylation:promoter (human)

RGD

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756

G

solute carrier family 2 member 2

mRNA:decreased expression:pancreatic islet

RGD

PMID:12114701 PMID:8421107

RGD:2324976, RGD:2324977

NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:111,611,774...111,639,933

Gastro-Enteropancreatic Neuroendocrine Tumor

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATM serine/threonine kinase

disease_progression

associated with Neoplasm Metastasis;mRNA, protein: decreased expression:gastrointestinal system, multiple (human)

RGD

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437

G

ATRX, chromatin remodeler

severity

RGD

NCBI chr X:74,916,548...75,062,880
Ensembl chr X:70,850,981...70,997,330

G

Cd53 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 2:197,040,369...197,087,925
Ensembl chr 2:194,352,139...194,399,657

G

CD86 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818

G

class II, major histocompatibility complex, transactivator

CTD Direct Evidence: marker/mechanism

NCBI chr10:5,646,854...5,694,393
Ensembl chr10:5,140,178...5,187,440

G

C-X-C motif chemokine receptor 4

severity

protein:increased expression:colon (human)

RGD

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:40,077,976...40,081,883

G

death-domain associated protein

severity

RGD

NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,970,092...4,975,843

G

eomesodermin

CTD Direct Evidence: marker/mechanism

NCBI chr 8:127,059,215...127,067,070
Ensembl chr 8:118,181,777...118,188,316

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr17:73,544,234...73,575,670
Ensembl chr17:68,643,873...68,665,391

G

growth factor independent 1 transcriptional repressor

CTD Direct Evidence: marker/mechanism

NCBI chr14:2,185,489...2,204,191
Ensembl chr14:2,042,434...2,051,814

G

IKAROS family zinc finger 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:90,468,696...90,556,522
Ensembl chr14:86,255,065...86,342,416

G

IKAROS family zinc finger 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:83,956,850...84,049,861
Ensembl chr10:83,465,745...83,553,591

G

interleukin 10

CTD Direct Evidence: marker/mechanism

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 2 receptor subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr 7:111,913,828...111,928,537
Ensembl chr 7:110,033,341...110,048,054

G

notch receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:185,610,589...185,744,088

G

POU class 2 homeobox 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:89,810,153...89,897,560
Ensembl chr 1:80,685,741...80,724,261

G

protein tyrosine phosphatase, receptor type, C

CTD Direct Evidence: marker/mechanism

NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692

G

RUNX family transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 5:152,644,270...152,702,835
Ensembl chr 5:147,360,994...147,419,156

G

serpin family A member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:122,866,312...122,888,339

Glucagonoma

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

betacellulin

protein:increased expression:pancreas

RGD

NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049

G

menin 1

DNA:deletion:exon
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17961653 PMID:20138042

NCBI chr 1:213,068,166...213,074,132
Ensembl chr 1:203,639,000...203,644,871

G

solute carrier family 2 member 2

mRNA:decreased expression:pancreatic islet

RGD

PMID:12114701 PMID:8421107

RGD:2324976, RGD:2324977

NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:111,611,774...111,639,933

G

somatostatin receptor 4

RGD

NCBI chr 3:156,307,992...156,309,855
Ensembl chr 3:135,854,826...135,856,689

insulinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenomedullin

protein:increased expression:pancreas, plasma

RGD

NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:164,745,466...164,747,654

G

betacellulin

protein:increased expression:pancreas

RGD

NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049

G

CD40 molecule

RGD

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534

G

cut-like homeobox 1

disease_progression
exacerbates

mRNA:increased expression:pancreas (mouse)
protein:increased expression:pancreas (human)

RGD

PMID:25248790 PMID:25248790

RGD:152985543, RGD:152985543

NCBI chr12:25,728,393...26,062,497
Ensembl chr12:20,107,311...20,425,866
Ensembl chr 4:20,107,311...20,425,866

G

C-X-C motif chemokine ligand 12

protein:increased expression:pancreas

RGD

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168

G

insulin 2

protein:altered expression:blood
protein:altered localization:pancreas

RGD

PMID:8175958 PMID:2565624

RGD:2317266, RGD:2317268

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775

G

menin 1

disease_progression

DNA:deletion:exon
CTD Direct Evidence: marker/mechanism
DNA:deletions:exons

CTD
RGD

PMID:17961653 PMID:12941803 PMID:20138042 PMID:19208834

RGD:2317292, RGD:2317288, RGD:2317310

NCBI chr 1:213,068,166...213,074,132
Ensembl chr 1:203,639,000...203,644,871

G

neural cell adhesion molecule 1

protein:increased expression:pancreas

RGD

NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:49,865,633...50,166,014

G

ribosomal protein S15

RGD

NCBI chr 7:10,066,572...10,068,167
Ensembl chr 7:9,416,004...9,417,450
Ensembl chr 7:9,416,004...9,417,450

G

solute carrier family 2 member 2

protein:increased expression:pancreatic B cell
mRNA:decreased expression:pancreatic islet

RGD

PMID:12114701 PMID:8421107

RGD:2324976, RGD:2324977

NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:111,611,774...111,639,933

G

transforming growth factor alpha

protein:increased expression:pancreas

RGD

NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

mRNA, protein:decreased expression:pancreatic islet

RGD

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

Islet Cell Adenomatosis

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

MAF bZIP transcription factor A

ClinVar Annotator: match by term: Islet cell adenomatosis

PMID:25741868 PMID:29339498 PMID:35406570

NCBI chr 7:109,313,021...109,315,813
Ensembl chr 7:107,433,605...107,434,690

islet cell tumor

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATRX, chromatin remodeler

disease_progression

protein:decreased expression:pancreas:

RGD

NCBI chr X:74,916,548...75,062,880
Ensembl chr X:70,850,981...70,997,330

G

cyclin-dependent kinase 4

protein:increased expression:pancreas, islet of Langerhans (human)

RGD

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403

G

death-domain associated protein

disease_progression

RGD

NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,970,092...4,975,843

G

proprotein convertase subtilisin/kexin type 1

protein:increased expression:insulinoma (rat)

RGD

NCBI chr 2:6,130,045...6,176,974
Ensembl chr 2:4,395,543...4,442,434

Islet Cell Tumor Syndrome

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

farnesyltransferase, CAAX box, subunit beta

ClinVar Annotator: match by term: Chromaffinoma

NCBI chr 6:101,269,657...101,352,716
Ensembl chr 6:95,470,683...95,619,586

G

MYC associated factor X

ClinVar Annotator: match by term: Chromaffinoma

PMID:21685915 PMID:22452945 PMID:23666964 PMID:25741868 PMID:26070438 More...

NCBI chr 6:101,369,989...101,395,333
Ensembl chr 6:95,636,858...95,662,137

G

myelin protein zero

ClinVar Annotator: match by term: Chromaffinoma

PMID:12807974 PMID:17468193 PMID:19454582 PMID:23342407 PMID:24033266 More...

NCBI chr13:86,103,290...86,109,156
Ensembl chr13:83,570,811...83,576,679

G

neurofibromin 1

ClinVar Annotator: match by term: Chromaffinoma

PMID:1568247 PMID:8264648 PMID:8499944 PMID:8499945 PMID:8669813 More...

NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,306,301...64,536,658

G

ret proto-oncogene

ClinVar Annotator: match by term: Chromaffinoma

PMID:2008030 PMID:2660074 PMID:2904651 PMID:3078962 PMID:7536460 More...

NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:151,326,431...151,368,176

G

succinate dehydrogenase complex assembly factor 2

ClinVar Annotator: match by term: Chromaffinoma

NCBI chr 1:207,139,070...207,167,830
Ensembl chr 1:207,139,112...207,168,616

G

succinate dehydrogenase complex iron sulfur subunit B

ClinVar Annotator: match by term: Chromaffinoma

PMID:490809 PMID:2308387 PMID:9509062 PMID:9536098 PMID:11404820 More...

NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:153,264,899...153,314,293

G

succinate dehydrogenase complex subunit C

ClinVar Annotator: match by term: Chromaffinoma

PMID:12807974 PMID:17468193 PMID:19454582 PMID:22517554 PMID:22703879 More...

NCBI chr13:86,077,133...86,098,025
Ensembl chr13:83,544,652...83,566,253

G

succinate dehydrogenase complex subunit D

ClinVar Annotator: match by term: Chromaffinoma

PMID:1945482 PMID:8981955 PMID:9536098 PMID:9683583 PMID:10323245 More...

NCBI chr 8:59,841,090...59,850,641
Ensembl chr 8:50,944,704...50,954,238

G

transmembrane protein 127

ClinVar Annotator: match by term: Chromaffinoma

PMID:9536098 PMID:16266984 PMID:17576681 PMID:20154675 PMID:20923864 More...

NCBI chr 3:134,919,416...134,932,210
Ensembl chr 3:114,466,171...114,477,519

G

von Hippel-Lindau tumor suppressor

ClinVar Annotator: match by term: Chromaffinoma

PMID:7563486 PMID:7987306 PMID:8707293 PMID:8772572 PMID:8956040 More...

NCBI chr 4:148,328,099...148,334,992
Ensembl chr 4:146,772,468...146,779,377

Melanoma-Pancreatic Cancer Syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin-dependent kinase inhibitor 2A

ClinVar Annotator: match by term: Melanoma-pancreatic cancer syndrome
CTD Direct Evidence: marker/mechanism

OMIM
ClinVar
CTD

PMID:2319082 PMID:2813514 PMID:5001868 PMID:7566978 PMID:7632931 More...

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149

non-functioning pancreatic endocrine tumor

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AT-rich interaction domain 1A

exacerbates

protein:decreased expression:endocrine pancreas (human)

NCBI chr 5:151,192,014...151,269,291
Ensembl chr 5:145,908,181...145,985,564

G

cyclin-dependent kinase 4

associated with multiple endocrine neoplasia type 1;mRNA:increased expression:islet of Langerhans (human)

RGD

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 6

associated with multiple endocrine neoplasia type 1;mRNA:increased expression:islet of Langerhans (human)

RGD

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634

pancreatic acinar cell adenocarcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

B-Raf proto-oncogene, serine/threonine kinase

DNA:missense mutation, gene fusions:multiple (human)

RGD

NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463

G

SRC proto-oncogene, non-receptor tyrosine kinase

disease_progression

RGD

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476

pancreatic adenocarcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adhesion G protein-coupled receptor B1

mRNA:decreased expression:pancreas

RGD

NCBI chr 7:108,293,681...108,365,892
Ensembl chr 7:106,404,958...106,476,902

G

AKT serine/threonine kinase 3

severity

mRNA:increased expression:pancreas (human)

RGD

NCBI chr13:91,475,839...91,758,060
Ensembl chr13:88,946,091...89,225,708

G

baculoviral IAP repeat-containing 2

exacerbates

mRNA:increased expression:pancreas (human)

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

disease_progression

mRNA:increased expression:pancreas (human)

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

exacerbates

mRNA:increased expression:pancreas (human)

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380

G

baculoviral IAP repeat-containing 7

exacerbates

mRNA:increased expression:pancreas (human)

NCBI chr 3:188,425,392...188,430,174
Ensembl chr 3:168,047,824...168,052,606

G

carbonyl reductase 4

ClinVar Annotator: match by term: Pancreatic adenocarcinoma

PMID:9536098 PMID:17576681 PMID:25741868 PMID:28166811 PMID:28492532

NCBI chr16:33,625,734...33,695,067
Ensembl chr16:28,617,224...28,645,712

G

cyclin D1

severity

protein:increased expression:pancreas (human)

RGD

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase 4

treatment

human cells in a mouse model

RGD

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 6

treatment

human cells in a mouse model

RGD

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 2A

DNA:missense mutations:cds:p.V126D, p.A148T (human)

RGD

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149

G

C-X-C motif chemokine receptor 4

RGD

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:40,077,976...40,081,883

G

E2F transcription factor 1

treatment

Human cells in a mouse model

RGD

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361

G

glutathione S-transferase theta 1

RGD

NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,669...12,873,585

G

histidine-rich glycoprotein

disease_progression

RGD

NCBI chr11:91,559,087...91,573,982
Ensembl chr11:78,054,498...78,069,389

G

Janus kinase 1

treatment

human cell line in a mouse model

RGD

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:115,780,248...115,888,926

G

mitogen activated protein kinase kinase 1

treatment
severity

human tissue in a mouse model
protein:increased expression:pancreas (human)

RGD

PMID:28849200 PMID:19513748

RGD:13838804, RGD:13838840

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase 1

severity

mRNA:increased expression:pancreas (human)

RGD

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 10

severity

DNA:SNP:intron: (rs2589506) (human)

RGD

NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,497,707...6,786,201

G

mitogen-activated protein kinase 8

exacerbates

protein:increased phosphorylation:pancreas (human)

RGD

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

RGD

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178

G

nuclear factor kappa B subunit 1

severity

mRNA:increased expression:pancreas (human)

RGD

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

palladin, cytoskeletal associated protein

ClinVar Annotator: match by term: Pancreatic adenocarcinoma

PMID:9536098 PMID:10454945 PMID:11474289 PMID:17194196 PMID:17415588 More...

NCBI chr16:33,238,943...33,632,236
Ensembl chr16:27,981,354...28,621,337

G

plasminogen activator, tissue type

mRNA:increased expression:pancreas (human)

RGD

NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223

G

Rac family small GTPase 1

treatment

human cells in a mouse model

RGD

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251

G

Raf-1 proto-oncogene, serine/threonine kinase

treatment

human cells in a mouse model

RGD

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317

G

RAS like proto-oncogene B

treatment

human cells in a mouse model

RGD

NCBI chr13:33,140,834...33,176,997
Ensembl chr13:30,588,033...30,624,202

G

ralA binding protein 1

treatment

human cells in a mouse model

RGD

NCBI chr 9:112,903,289...112,940,093
Ensembl chr 9:105,456,425...105,492,707

G

SMAD family member 7

severity

human cell and construct in a mouse model

RGD

NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765

G

signal transducer and activator of transcription 1

ameliorates

protein:increased expression:pancreas (human)

RGD

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540

G

vascular endothelial growth factor C

exacerbates

protein:increased expression:pancreas (human)

RGD

NCBI chr16:44,445,293...44,560,887
Ensembl chr16:37,712,262...37,827,848

pancreatic adenosquamous carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

transforming growth factor, beta 2

ameliorates

human cells in a mouse model

RGD

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405

pancreatic cancer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1,4-N-acetylglucosaminyltransferase

mRNA:increased expression:blood, mononuclear cell

RGD

NCBI chr 8:100,172,038...100,179,218
Ensembl chr 8:100,172,104...100,178,569

G

ATP binding cassette subfamily C member 2

mRNA, protein:increased expression:pancreas

RGD

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

severity

mRNA:increased expression:pancreas

RGD

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 5

mRNA:increased expression:pancreas

RGD

NCBI chr11:93,975,579...94,071,659
Ensembl chr11:80,473,872...80,567,253

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:19648918 PMID:26098869 PMID:20103627

NCBI chr 3:30,560,172...30,604,758
Ensembl chr 3:10,162,096...10,191,423

G

angiotensin I converting enzyme

RGD

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131

G

activin A receptor type 1

RGD

NCBI chr 3:63,387,378...63,506,980
Ensembl chr 3:42,978,561...43,098,241

G

activin A receptor type 1B

mRNA:increased expression:pancreas
CTD Direct Evidence: marker/mechanism

PMID:9714055 PMID:11248065

RGD:2317217, RGD:1598735

NCBI chr 7:134,164,987...134,208,389
Ensembl chr 7:132,286,275...132,329,673

G

activin A receptor type 2A

RGD

NCBI chr 3:53,614,143...53,701,933
Ensembl chr 3:33,205,523...33,289,968

G

ADAM metallopeptidase domain 15

mRNA:increased expression:pancreas, epithelial cell

RGD

NCBI chr 2:177,052,363...177,062,879
Ensembl chr 2:174,754,633...174,765,113

G

ADAM metallopeptidase domain 9

mRNA:increased expression:pancreas, epithelial cell

RGD

NCBI chr16:73,725,186...73,804,284
Ensembl chr16:67,022,655...67,100,917

G

adhesion G protein-coupled receptor E5

protein:increased expression:pancreas

RGD

NCBI chr19:41,302,687...41,332,183
Ensembl chr19:24,398,689...24,418,638

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

DNA:polymorphism: :p.R272Q (human)

RGD

NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:226,797,303...226,808,892

G

adrenomedullin

disease_progression

RGD

PMID:17363587 PMID:16841081

RGD:2325317, RGD:2325318

NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:164,745,466...164,747,654

G

advanced glycosylation end product-specific receptor

protein:decreased expression:serum

RGD

NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078

G

angiotensin II receptor, type 2

mRNA:increased expression:pancreas

RGD

NCBI chr X:116,914,320...116,918,504
Ensembl chr X:112,120,228...112,124,057

G

aryl hydrocarbon receptor

mRNA:increased expression:pancreas
CTD Direct Evidence: marker/mechanism|therapeutic

CTD
RGD

PMID:12203118 PMID:25826687 PMID:12203118

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

G

AKT serine/threonine kinase 1

severity
treatment

protein:increased phosphorylation:pancreas (human)
human cells in a mouse model

RGD

PMID:20697673 PMID:11595724

RGD:13450953, RGD:13452388

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

RGD

PMID:16847462 PMID:19506583

RGD:2290476, RGD:5490965

NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817

G

albumin

disease_progression

RGD

PMID:18154768 PMID:20508721

RGD:2325678, RGD:2325675

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

protein:decreased expression:pancreas

RGD

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 2 family member

susceptibility

DNA:polymorphism: :p.E504K (human)
DNA:polymorphism (human)

RGD

PMID:19068087 PMID:15714130

RGD:2325313, RGD:2325694

NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521

G

arachidonate 12-lipoxygenase, 12R type

CTD Direct Evidence: marker/mechanism

NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938

G

arachidonate 5-lipoxygenase

protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:30258081 PMID:12163367 PMID:12481414

RGD:2317524, RGD:2317523

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:149,531,515...149,578,743

G

angiogenin

disease_progression

mRNA, protein:increased expression:pancreas, serum

RGD

NCBI chr15:26,786,233...26,796,883

G

annexin A1

protein:increased expression:pancreas

RGD

PMID:19173988 PMID:17974280

RGD:2325722, RGD:2325723

NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:217,861,175...217,877,343

G

annexin A10

CTD Direct Evidence: marker/mechanism

NCBI chr16:32,505,025...32,571,961
Ensembl chr16:27,738,712...27,805,648

G

apoptotic peptidase activating factor 1

mRNA:increased expression:pancreas

RGD

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540

G

APC regulator of WNT signaling pathway

DNA:deletions (human)
ClinVar Annotator: match by term: Cancer of the pancreas
DNA:mutation, loss of heterozygosity

PMID:1316610 PMID:8381579 PMID:9101302 PMID:9824584 PMID:11852337 More...

RGD:2317208, RGD:2317207

NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696

G

apolipoprotein A1

protein:decreased expression:serum
protein:increased expression:pancreas

RGD

PMID:17312459 PMID:17332923

RGD:2325758, RGD:2325757

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein E

protein:increased expression:pancreas (human)

RGD

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932

G

AT-rich interaction domain 1A

RGD

NCBI chr 5:151,192,014...151,269,291
Ensembl chr 5:145,908,181...145,985,564

G

AT-rich interaction domain 1B

RGD

NCBI chr 1:47,973,199...48,328,793
Ensembl chr 1:45,563,623...45,923,493

G

actin related protein 2/3 complex, subunit 1A

DNA:amplification (human)

RGD

NCBI chr12:9,502,496...9,525,304
Ensembl chr12:9,502,501...9,525,330

G

artemin

disease_progression

mRNA:increased expression:pancreas

RGD

PMID:20395845 PMID:19304517

RGD:2325815, RGD:2325817

NCBI chr 5:136,750,188...136,755,645
Ensembl chr 5:131,464,756...131,468,025

G

ATM serine/threonine kinase

susceptibility

DNA:SNP:intron:rs664677 (human)
ClinVar Annotator: match by term: Pancreatic cancer
CTD Direct Evidence: marker/mechanism
DNA:SNP:exon:rs1801516(human)
DNA:SNP: :60G>A(human)

ClinVar
CTD
RGD

PMID:8698354 PMID:8845835 PMID:9497252 PMID:9536098 PMID:9792409 More...

RGD:2317367, RGD:2317363, RGD:2317234

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437

G

ATR serine/threonine kinase

DNA:SNP: :340C>T (human)

RGD

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:96,426,724...96,524,136

G

ATRX, chromatin remodeler

CTD Direct Evidence: marker/mechanism

NCBI chr X:74,916,548...75,062,880
Ensembl chr X:70,850,981...70,997,330

G

Axl receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:81,265,088...81,296,265

G

Beta-1,3-galactosyltransferase 5

mRNA:increased expression:pancreas

RGD

NCBI chr11:49,053,959...49,100,398
Ensembl chr11:35,585,220...35,630,917

G

BCL2-associated agonist of cell death

treatment

human cells in a mouse model

RGD

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823

G

BAG cochaperone 3

mRNA:increased expression:pancreas

RGD

NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:183,102,871...183,126,858

G

BAG cochaperone 4

mRNA:increased expression:pancreas

RGD

NCBI chr16:72,991,407...73,008,620
Ensembl chr16:66,288,678...66,308,663

G

BRCA1 associated deubiquitinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:6,453,126...6,461,952
Ensembl chr16:6,446,709...6,455,535

G

BCAR1 scaffold protein, Cas family member

CTD Direct Evidence: marker/mechanism

NCBI chr19:56,588,500...56,623,190
Ensembl chr19:39,679,204...39,713,907

G

Bcl2-like 1

severity

human gene in a mouse model
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16904634 PMID:17941720

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

BH3 interacting domain death agonist

RGD

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720

G

BOC cell adhesion associated, oncogene regulated

RGD

NCBI chr11:56,122,697...56,198,060
Ensembl chr11:56,122,750...56,198,059

G

B-Raf proto-oncogene, serine/threonine kinase

disease_progression

human gene in a mouse model

RGD

PMID:18490924 PMID:22628411 PMID:22871572

RGD:13451537, RGD:13462040, RGD:13461863

NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463

G

BRCA1, DNA repair associated

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4

CTD
OMIM
ClinVar

PMID:1157798 PMID:2173504 PMID:2316185 PMID:2504116 PMID:2618727 More...

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304

G

BRCA2, DNA repair associated

susceptibility

DNA:mutations: :
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2
CTD Direct Evidence: marker/mechanism

ClinVar
OMIM
CTD
RGD

PMID:186727 PMID:251866 PMID:278235 PMID:1772447 PMID:2200631 More...

NCBI chr12:4,895,092...4,939,340
Ensembl chr12:59,819...100,567

G

basigin

CTD Direct Evidence: marker/mechanism

NCBI chr 7:10,643,788...10,651,005
Ensembl chr 7:9,993,170...10,000,387

G

BUB1 mitotic checkpoint serine/threonine kinase B

protein:altered localization:pancreas

RGD

NCBI chr 3:126,017,019...126,069,470
Ensembl chr 3:105,563,138...105,615,547

G

calcium binding protein 39

disease_progression

RGD

NCBI chr 9:93,911,099...93,972,542
Ensembl chr 9:86,463,095...86,524,544

G

calcyclin binding protein

disease_progression

mRNA, protein:increased expression:pancreas

RGD

NCBI chr13:74,970,917...74,981,298
Ensembl chr13:72,437,490...72,450,177

G

cyclase associated actin cytoskeleton regulatory protein 1

disease_progression

mRNA, protein:increased expression:pancreas

RGD

NCBI chr 5:140,427,265...140,507,678
Ensembl chr 5:135,142,112...135,168,769

G

calpain 10

susceptibility

DNA:SNP:intron:rs3792267 (human)

RGD

NCBI chr 9:100,943,665...100,957,910
Ensembl chr 9:93,498,478...93,510,494

G

caspase 8

susceptibility

DNA:SNP: :rs1045485 (human)
DNA:deletion, insertion:promoter (human)

RGD

PMID:19843670 PMID:18483392

RGD:2317230, RGD:2315744

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

susceptibility
treatment

DNA:snp:promoter:g.-1263A>G (human)

RGD

PMID:20357690 PMID:19209030

RGD:13451540, RGD:13462046

Ensembl chr 5:154,109,046...154,126,626

G

catalase

disease_progression

protein:decreased expression:pancreas

RGD

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

carbonyl reductase 4

ClinVar Annotator: match by term: PALLD-related condition | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1

PMID:25741868 PMID:28492532

NCBI chr16:33,625,734...33,695,067
Ensembl chr16:28,617,224...28,645,712

G

cholecystokinin A receptor

mRNA:increased expression:pancreas

RGD

PMID:8222074 PMID:10457335

RGD:4110822, RGD:4110817

NCBI chr14:61,505,270...61,513,618
Ensembl chr14:57,292,397...57,300,747

G

cholecystokinin B receptor

disease_progression
susceptibility

mRNA:increased expression:pancreas

RGD

PMID:8302799 PMID:8222074 PMID:1458479 PMID:15688412

RGD:4110823, RGD:4110822, RGD:4110821, RGD:4110829

NCBI chr 1:169,183,578...169,193,583
Ensembl chr 1:159,771,733...159,814,881

G

C-C motif chemokine ligand 20

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:30603057 PMID:10225458

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 5

RGD

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377

G

cyclin D1

disease_progression
treatment

human cells in a mouse model
mRNA, protein:increased expression:pancreas (mouse)

RGD

PMID:22722256 PMID:11159909 PMID:17541034

RGD:13451541, RGD:13452385, RGD:13462059

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin G1

treatment

human cells in mouse model

RGD

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,176,234...25,181,641

G

C-C motif chemokine receptor 4

protein:increased expression:pancreas

RGD

NCBI chr 8:123,054,505...123,060,244
Ensembl chr 8:114,176,974...114,178,056

G

C-C motif chemokine receptor 5

RGD

NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:123,752,325...123,759,260

G

CD24 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr20:48,655,549...48,661,786
Ensembl chr20:47,073,512...47,079,662

G

CD44 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620

G

cell division cycle 42

severity

mRNA, protein:increased expression:pancreas (human)

RGD

NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:149,553,724...149,593,111

G

cadherin 1

CTD Direct Evidence: marker/mechanism

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase 4

susceptibility
disease_progression

protein:increased expression:islet of Langerhans (human)
protein:increased expression:islet of Langerhans, nucleus (rat)
protein:increased expression:pancreas (mouse)

RGD

PMID:22761470 PMID:24531709 PMID:22477723 PMID:11159909

RGD:13452384, RGD:13452387, RGD:13452386, RGD:13452385

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 2A

DNA:mutations:exon
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:10627132 PMID:26098869 PMID:18772397

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149

G

CASP8 and FADD-like apoptosis regulator

CTD Direct Evidence: marker/mechanism

NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034

G

CF transmembrane conductance regulator

no_association
onset

RGD

PMID:17072959 PMID:16227367

RGD:2317157, RGD:2317156

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756

G

checkpoint kinase 1

disease_progression

DNA:SNP: :35G>A (human)

RGD

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:36,420,569...36,441,009

G

claudin 4

RGD

PMID:19555390 PMID:19793693

RGD:2317583, RGD:2317580

NCBI chr12:27,388,160...27,389,958
Ensembl chr12:21,751,331...21,753,436

G

CLPTM1 regulator of GABA type A receptor forward trafficking

CTD Direct Evidence: marker/mechanism

NCBI chr 1:79,289,478...79,321,079
Ensembl chr 1:79,289,477...79,321,092

G

cannabinoid receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:48,408,574...48,435,099

G

cannabinoid receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:148,125,604...148,151,548

G

catenin beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome c, somatic

RGD

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 17, subfamily a, polypeptide 1

susceptibility

DNA:transition:5' utr:-34T>C rs743572 (human)

RGD

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 2, subfamily b, polypeptide 1

CTD Direct Evidence: therapeutic

PMID:10026857 PMID:10326030 PMID:10415878 PMID:11332152 PMID:11377651 More...

NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052

G

death-domain associated protein

CTD Direct Evidence: marker/mechanism

NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,970,092...4,975,843

G

discoidin domain receptor tyrosine kinase 1

treatment

RGD

NCBI chr20:3,047,269...3,069,277
Ensembl chr20:3,044,320...3,064,468

G

dihydropyrimidine dehydrogenase

disease_progression

CTD Direct Evidence: marker/mechanism
protein:increased expression:pancreas

CTD
RGD

PMID:17443278 PMID:19020767 PMID:18309485 PMID:20072795

RGD:2317630, RGD:2317629

NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:206,609,122...207,474,982

G

dual specificity tyrosine phosphorylation regulated kinase 1A

CTD Direct Evidence: marker/mechanism

NCBI chr11:47,360,824...47,479,033
Ensembl chr11:33,890,490...34,009,420

G

E2F transcription factor 1

treatment

RGD

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361

G

EGF containing fibulin extracellular matrix protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:106,811,769...106,890,961
Ensembl chr14:102,610,908...102,690,018

G

epidermal growth factor

disease_progression

protein:increased expression:pancreas

RGD

PMID:1347773 PMID:19506583

RGD:2317650, RGD:5490965

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:27720938 PMID:17452677 PMID:19506583

RGD:5131631, RGD:5490965

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 4A3

protein:increased expression:serum (human)

RGD

NCBI chr10:105,047,567...105,057,561
Ensembl chr10:104,549,038...104,559,057

G

epithelial cell adhesion molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:6,878,237...6,896,127

G

Eph receptor A3

RGD

NCBI chr11:14,585,041...14,920,721
Ensembl chr11:1,140,985...1,473,900

G

ERCC excision repair 1, endonuclease non-catalytic subunit

susceptibility

DNA:snp:3' utr:c.*197G>T (rs3212986) (human)

RGD

NCBI chr 1:88,099,308...88,135,966
Ensembl chr 1:78,996,390...79,007,963

G

ERCC excision repair 2, TFIIH core complex helicase subunit

treatment

pancreatic adenocarcinoma;DNA:SNPs: :rs1799793,rs1052555(human)
DNA,protein:SNPs:exons:rs1799793,rs1052559(human)

RGD

PMID:18544627 PMID:21404106 PMID:16458430

RGD:2317223, RGD:11252206, RGD:2317228

NCBI chr 1:88,161,342...88,175,102
Ensembl chr 1:79,033,326...79,047,102

G

ERCC excision repair 4, endonuclease catalytic subunit

pancreatic adenocarcinoma;DNA:SNP: :rs1800067(human)

RGD

NCBI chr10:2,926,085...2,958,176
Ensembl chr10:2,419,038...2,448,369
Ensembl chr10:2,419,038...2,448,369

G

ETAA1 activator of ATR kinase

CTD Direct Evidence: marker/mechanism

NCBI chr14:96,500,899...96,515,617
Ensembl chr14:92,299,553...92,314,104

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

protein:increased expression:pancreas

RGD

NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:76,624,399...76,687,362

G

FA complementation group A

DNA,Protein:polymorphisms:exons:c.377C>G, c.661A>G (human)

RGD

NCBI chr19:68,210,562...68,271,080
Ensembl chr19:51,304,021...51,362,527

G

FA complementation group C

DNA:nonsense mutation (human)

RGD

PMID:16243825 PMID:15695377

RGD:2317238, RGD:2317239

NCBI chr17:1,686,374...1,818,672
Ensembl chr17:1,681,324...1,829,376

G

FA complementation group G

RGD

NCBI chr 5:62,027,494...62,037,202
Ensembl chr 5:57,231,685...57,240,029

G

Fas ligand

severity
resistance

DNA:polymorphism:promoter:-844>>T (human)

RGD

PMID:11115536 PMID:12370548 PMID:18483392

RGD:2317745, RGD:2317744, RGD:2315744

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215

G

fibroblast growth factor 13

CTD Direct Evidence: marker/mechanism

NCBI chr X:142,312,381...142,838,581
Ensembl chr X:137,276,511...137,800,391

G

fibroblast growth factor 2

severity

mRNA:increased expression:pancreas
protein:increased expression:bile

RGD

PMID:9293890 PMID:11562741 PMID:11478488 PMID:12670449

RGD:2317762, RGD:2317760, RGD:2317765, RGD:2317759

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221

G

Fms related receptor tyrosine kinase 3 ligand

RGD

NCBI chr 1:104,751,518...104,756,925
Ensembl chr 1:95,609,370...95,620,463

G

forkhead box P1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:131,564,756...132,112,258

G

fascin actin-bundling protein 1

severity

protein:increased expression:pancreas

RGD

NCBI chr12:16,710,601...16,723,734
Ensembl chr12:11,597,048...11,610,211

G

FXYD domain-containing ion transport regulator 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:95,432,918...95,440,129

G

growth arrest and DNA-damage-inducible, alpha

CTD Direct Evidence: therapeutic

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115

G

glial cell derived neurotrophic factor

severity

RGD

NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:56,895,010...56,917,209

G

GLI family zinc finger 1

RGD

PMID:21186299 PMID:18772397

RGD:5491005, RGD:5490966

NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:63,156,926...63,169,251

G

GLI family zinc finger 3

RGD

NCBI chr17:54,134,064...54,405,198
Ensembl chr17:49,438,567...49,709,712

G

GNAS complex locus

RGD

NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

golgi membrane protein 1

RGD

NCBI chr17:4,996,978...5,049,278
Ensembl chr17:4,996,104...5,034,057

G

glutathione S-transferase pi 1

susceptibility

DNA:SNP:cds:p.I105V (rs1695) (human)

RGD

PMID:19536452 PMID:19786118

RGD:2317805, RGD:2317804

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226

G

hepatocyte growth factor

protein:increased expression:serum

RGD

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409

G

hypoxia inducible factor 1 subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

heparan sulfate-glucosamine 3-sulfotransferase 2

DNA:hypermethylation:promoter (human)

RGD

NCBI chr 1:185,387,445...185,508,700
Ensembl chr 1:175,956,157...176,077,399

G

heat shock protein family B (small) member 1

disease_progression

RGD

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743

G

intercellular adhesion molecule 1

mRNA, protein:increased expression:pancreas

RGD

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

interferon, alpha 1

CTD Direct Evidence: therapeutic

PMID:17198089 PMID:17961653

NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:103,097,356...103,097,925

G

interferon gamma

protein:increased expression:plasma

RGD

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

susceptibility

DNA:polymorphism (human)

RGD

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

RGD

PMID:14559833 PMID:19732452 PMID:19885860

RGD:2317651, RGD:2317642, RGD:2317640

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777

G

interleukin 10

disease_progression
susceptibility

protein:increased expression:serum
DNA:polymorphism: :-1082G>A (human)

RGD

PMID:17235586 PMID:30304975 PMID:30610790 PMID:19250218

RGD:2317655, RGD:14975257, RGD:14975253, RGD:2317653

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

disease_progression

protein:increased expression:pancreas

RGD

PMID:18758789 PMID:12808442

RGD:2317669, RGD:2317670

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737

G

interleukin 13 receptor subunit alpha 2

treatment

RGD

NCBI chr X:115,814,620...115,886,080
Ensembl chr X:111,002,592...111,072,381

G

interleukin 1 alpha

RGD

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

susceptibility

DNA:polymorphisms:promoter:-511C>T, -31T>C (human)
protein:increased expression:serum (human)

RGD

PMID:19251436 PMID:7787209

RGD:2317215, RGD:2311069

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

treatment

RGD

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 24

CTD Direct Evidence: therapeutic

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:42,353,090...42,358,487

G

interleukin 3

protein:increased expression:serum

RGD

NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,405,716...38,408,066

G

interleukin 4

disease_progression

protein:increased expression:blood

RGD

PMID:19957810 PMID:12097255 PMID:10404069

RGD:2317261, RGD:2317265, RGD:2317267

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

interleukin 4 receptor

disease_progression

protein:increased expression:pancreas

RGD

NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:180,115,120...180,139,980

G

interleukin 6

disease_progression

RGD

PMID:30610790 PMID:30304975

RGD:14975253, RGD:14975257

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

integrin-linked kinase

DNA:mutations:exon

RGD

NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:160,088,897...160,095,140

G

inositol polyphosphate-4-phosphatase type II B

CTD Direct Evidence: marker/mechanism

NCBI chr19:42,824,710...43,575,039
Ensembl chr19:25,925,358...26,280,634

G

insulin 2

susceptibility
disease_progression

associated with Diabetes Mellitus
DNA:Polymorphism:promoter:-23 HphI (human)
associated with Diabetes Mellitus, Non-Insulin-Depend

RGD

PMID:19375425 PMID:19152242 PMID:19628082 PMID:19572116

RGD:2317250, RGD:2317253, RGD:2317245, RGD:2317247

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775

G

integrin subunit alpha 11

DNA:mutations:exon

RGD

NCBI chr 8:72,041,432...72,150,137
Ensembl chr 8:63,146,001...63,254,407

G

integrin subunit alpha 4

DNA:mutations:exon

RGD

NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:64,163,085...64,233,715

G

integrin subunit alpha 9

DNA:mutations:exon

RGD

NCBI chr 8:127,185,244...127,493,296
Ensembl chr 8:118,307,381...118,613,754

G

kinase insert domain receptor

CTD Direct Evidence: therapeutic

CTD
RGD

PMID:12385004 PMID:19930156

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018

G

KLF transcription factor 5

CTD Direct Evidence: marker/mechanism

NCBI chr15:82,472,081...82,487,267
Ensembl chr15:76,064,258...76,079,445

G

KRAS proto-oncogene, GTPase

disease_progression

CTD Direct Evidence: marker/mechanism

PMID:14520703 PMID:19424582 PMID:21699781 PMID:24694877 PMID:25961927 More...

RGD:1581761, RGD:5490966, RGD:5490965

NCBI chr 4:179,916,255...179,949,613

G

L1 cell adhesion molecule

treatment

RGD

NCBI chr X:156,748,597...156,775,116
Ensembl chr X:151,597,277...151,623,857

G

lactate dehydrogenase A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472

G

DNA ligase 3

resistance

DNA:SNP:intron:rs 2074522 (human)

RGD

NCBI chr10:68,215,371...68,238,705
Ensembl chr10:67,717,812...67,798,414

G

DNA ligase 4

susceptibility

associated with Diabetes Mellitus;DNA:polymorphism: :54C>T (human)

RGD

NCBI chr16:86,220,345...86,228,930
Ensembl chr16:79,518,312...79,527,040

G

interferon alpha-1-like

CTD Direct Evidence: therapeutic

NCBI chr 5:103,227,820...103,230,500

G

LDL receptor related protein 2

RGD

NCBI chr 3:74,597,148...74,754,535
Ensembl chr 3:54,189,308...54,346,708

G

lumican

disease_progression

DNA:SNP: :rs2268578 (human)

RGD

PMID:19843670 PMID:17671699

RGD:2317230, RGD:2317682

NCBI chr 7:34,245,323...34,252,510
Ensembl chr 7:32,358,614...32,365,793

G

lymphocyte antigen 6 family member E

CTD Direct Evidence: marker/mechanism

NCBI chr 7:108,815,970...108,820,444
Ensembl chr 7:106,935,761...106,939,689

G

mesencephalic astrocyte-derived neurotrophic factor

no_association

DNA:point mutations, deletions:cds:multiple (human)
DNA:polymorphisms: :multiple (human)

RGD

PMID:9174057 PMID:17072959

RGD:2325804, RGD:2317157

NCBI chr 8:116,427,053...116,430,259
Ensembl chr 8:107,548,352...107,551,438

G

mitogen activated protein kinase kinase 4

RGD

NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,344,915...50,447,993

G

menin 1

associated with Neuroendocrine Tumors; protein:increased expression:multiple organs
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17961653 PMID:21252315 PMID:17278096

NCBI chr 1:213,068,166...213,074,132
Ensembl chr 1:203,639,000...203,644,871

G

MET proto-oncogene, receptor tyrosine kinase

severity

protein:increased expression:pancreas (rat)
mRNA:increased expression:pancreas (human)

RGD

PMID:9211490 PMID:19506583 PMID:15448002

RGD:2317613, RGD:5490965, RGD:2317235

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876

G

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

RGD

NCBI chr 9:39,673,427...39,786,747
Ensembl chr 9:39,673,430...39,766,890

G

O-6-methylguanine-DNA methyltransferase

protein:decreased expression:neuroendocrine tumor (human)

RGD

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756

G

microRNA 107

severity

RGD

NCBI chr 1:241,750,418...241,750,504
Ensembl chr 1:232,337,767...232,337,853

G

marker of proliferation Ki-67

disease_progression

protein:increased expression:pancreas

RGD

PMID:20137856 PMID:20350215

RGD:2317704, RGD:2317703

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 2

mRNA:increased expression:pancreas
CTD Direct Evidence: marker/mechanism
protein:increased activity:pancreatic juice

CTD
RGD

PMID:30603057 PMID:7635566 PMID:11961486

RGD:2325766, RGD:2325752

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

disease_progression

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:pancreas
protein:increased expression:serum

CTD
RGD

PMID:22952646 PMID:18445772 PMID:7635566 PMID:19629003 PMID:18030366

RGD:2325849, RGD:2325766, RGD:2325831, RGD:2325854

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

resistance

DNA:polymorphism:promoter:-463G>A (human)

RGD

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819

G

mesothelin

CTD Direct Evidence: marker/mechanism
associated with Pancreatic Disease; protein:increased expression:pancreas

CTD
RGD

PMID:11751476 PMID:19843662 PMID:18281514 PMID:17785569 PMID:17019794

RGD:2326052, RGD:2326056, RGD:2326062, RGD:2326060

NCBI chr10:15,276,489...15,285,921
Ensembl chr10:14,771,961...14,777,643

G

methylthioadenosine phosphorylase

DNA, protein:deletion, decreased activity:pancreas:

RGD

NCBI chr 5:108,990,270...109,036,494
Ensembl chr 5:103,873,020...103,939,406

G

methylenetetrahydrofolate reductase

susceptibility

DNA:polymorphism: :677C>T (human)

RGD

NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797

G

mechanistic target of rapamycin kinase

RGD

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

5-methyltetrahydrofolate-homocysteine methyltransferase

susceptibility
no_association

DNA:Polymorphism: :rs1805087 (human)

RGD

PMID:18843018 PMID:16737574

RGD:2317118, RGD:2317120

NCBI chr17:62,911,705...62,996,544
Ensembl chr17:58,220,071...58,304,822

G

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

susceptibility

DNA:polymorphism: :66A>G (human)
DNA:SNPs:intron, exon:rs162049, p.H595Y (rs10380) (human)

RGD

PMID:18843018 PMID:18515090

RGD:2317118, RGD:2325772

NCBI chr 1:36,695,376...36,727,341
Ensembl chr 1:34,867,089...34,899,425

G

mucin 1, cell surface associated

disease_progression

protein:increased expression:pancreas
protein:increased secretion:bile

RGD

PMID:14654947 PMID:18039393 PMID:18383873 PMID:19129927 PMID:19055478 More...

RGD:2317984, RGD:2324639, RGD:2324637, RGD:2317987, RGD:2324622, RGD:2324635

NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:174,635,995...174,640,733

G

mucin 16, cell surface associated

protein:increased expression:serum

RGD

NCBI chr 8:24,440,840...24,644,494

G

mucin 4, cell surface associated

disease_progression

mRNA:increased expression:peripheral blood mononuclear cell
protein:increased expression:pancreas
mRNA:increased expression:pancreas

RGD

PMID:16274046 PMID:17595659 PMID:20303649 PMID:11751498 PMID:17406026

RGD:2324931, RGD:2324922, RGD:2324914, RGD:2324891, RGD:2324923

NCBI chr11:81,513,321...81,575,200

G

mucin 5AC, oligomeric mucus/gel-forming

protein:increased glycosylation:serum
protein:increased expression:pancreas

RGD

PMID:19377061 PMID:14654947

RGD:2325129, RGD:2317984

NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:196,864,336...196,896,475

G

mucin 6, oligomeric mucus/gel-forming

protein:increased expression: :

RGD

NCBI chr 1:206,155,826...206,194,384
Ensembl chr 1:196,726,807...196,764,842

G

MYC proto-oncogene, bHLH transcription factor

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:25961927 PMID:22024988

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

G

nucleosome assembly protein 1-like 1

human gene in a mouse model

RGD

NCBI chr 7:48,819,464...48,844,108
Ensembl chr 7:46,933,356...46,956,593

G

N-acetyltransferase 1

susceptibility

DNA:polymorphism (human)
DNA:polymorphisms,haplotype: :

RGD

PMID:18006927 PMID:18006927 PMID:18499698

RGD:2317170, RGD:2317170, RGD:2317168

NCBI chr16:26,984,882...27,005,194
Ensembl chr16:22,208,194...22,238,520

G

N-acetyltransferase 2

susceptibility

DNA:polymorphism (human)

RGD

NCBI chr16:26,974,874...27,005,191
Ensembl chr16:22,208,194...22,238,520

G

neural cell adhesion molecule 1

severity
disease_progression

RGD

PMID:10374842 PMID:11249065

RGD:2326075, RGD:2326074

NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:49,865,633...50,166,014

G

NFKB inhibitor alpha

CTD Direct Evidence: therapeutic

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941

G

nerve growth factor receptor

severity

mRNA:increased expression:tumor:associated with longer overall survival (human)

RGD

NCBI chr10:81,012,077...81,030,305
Ensembl chr10:80,515,299...80,533,518

G

nitric oxide synthase 2

disease_progression

protein:increased expression:pancreas

RGD

PMID:11196200 PMID:11687972 PMID:15165031

RGD:2325262, RGD:2325257, RGD:2325248

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 1

disease_progression

protein:increased expression:pancreas

RGD

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531

G

nuclear receptor subfamily 4, group A, member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 5, group A, member 2

CTD Direct Evidence: marker/mechanism

PMID:20101243 PMID:26098869

NCBI chr13:50,865,253...50,985,107
Ensembl chr13:48,316,301...48,433,326

G

neuropilin 1

CTD Direct Evidence: marker/mechanism

NCBI chr19:73,256,557...73,411,705
Ensembl chr19:56,359,455...56,513,633

G

neurotrophic receptor tyrosine kinase 1

severity

mRNA:increased expression:tumor:associated with increased tumor aggressiveness (human)

RGD

NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:173,236,963...173,253,770

G

NUF2 component of NDC80 kinetochore complex

treatment

mRNA:increased expression:pancreas

RGD

PMID:26045769 PMID:25370920

RGD:11058437, RGD:28867232

NCBI chr13:84,226,448...84,290,957
Ensembl chr13:81,693,598...81,722,766

G

8-oxoguanine DNA glycosylase

disease_progression

DNA:polymorphism: :2657G>A (human)
DNA:polymorphism: :rs1052133 (human)

RGD

PMID:17230526 PMID:18559563

RGD:2317132, RGD:2317130

NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:146,474,750...146,484,766

G

partner and localizer of BRCA2

susceptibility

DNA:nonsense mutations:exon:172_175del, 3116del, 3256C>T (human)
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 4
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 3
ClinVar Annotator: match by term: Cancer of the pancreas | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 1 | ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Pancreatic cancer 3
CTD Direct Evidence: marker/mechanism

OMIM
ClinVar
CTD
RGD

PMID:100849 PMID:9536098 PMID:16199547 PMID:17200668 PMID:17200671 More...

NCBI chr 1:186,096,312...186,120,284
Ensembl chr 1:176,665,076...176,688,990

G

palladin, cytoskeletal associated protein

susceptibility

DNA, mRNA:missense mutation, increased expression:pancreas:p.P239S (human)
ClinVar Annotator: match by term: PALLD-related condition | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 2
ClinVar Annotator: match by term: PALLD-related condition | ClinVar Annotator: match by term: Pancreatic cancer 3 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1
ClinVar Annotator: match by term: PANCREATIC CANCER, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 1
CTD Direct Evidence: marker/mechanism
protein:increased expression, alternative form:pancreas, fibroblast

ClinVar
CTD
OMIM
RGD

PMID:10454945 PMID:11474289 PMID:17194196 PMID:17415588 PMID:24033266 More...

RGD:2325782, RGD:2325779

NCBI chr16:33,238,943...33,632,236
Ensembl chr16:27,981,354...28,621,337

G

polybromo 1

RGD

NCBI chr16:6,219,933...6,319,336
Ensembl chr16:6,213,300...6,311,780

G

platelet derived growth factor receptor alpha

mRNA:increased expression:pancreas

RGD

PMID:7665222 PMID:14695158

RGD:2324851, RGD:2324850

NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,005,839...33,054,335

G

pancreatic and duodenal homeobox 1

CTD Direct Evidence: marker/mechanism

PMID:19077462 PMID:25086665 PMID:26098869

NCBI chr12:12,793,957...12,799,156
Ensembl chr12:7,757,865...7,763,064

G

profilin 1

RGD

NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,365,262...55,527,631

G

plasminogen activator, urokinase

CTD Direct Evidence: marker/mechanism

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775

G

DNA polymerase beta

disease_progression

DNA:polymorphisms: :165A>G, 2133T>C (human)

RGD

NCBI chr16:76,081,903...76,105,174
Ensembl chr16:69,379,400...69,404,812

G

peroxisome proliferator-activated receptor delta

disease_progression

PMID:17652168 PMID:17652168

RGD:2324872, RGD:2324872

NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,298,785...6,363,968

G

peroxisome proliferator-activated receptor gamma

susceptibility

DNA:polymorphism: :p.P12A (human)
CTD Direct Evidence: marker/mechanism|therapeutic

CTD
RGD

PMID:11034103 PMID:11741176 PMID:19436234 PMID:19152448

RGD:2317460, RGD:2317462

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

patched 1

protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:19077462 PMID:19396459

NCBI chr17:1,548,449...1,613,461
Ensembl chr17:1,542,877...1,607,333

G

phosphatase and tensin homolog

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:19917848 PMID:19506583

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin-endoperoxide synthase 2

susceptibility

mRNA, protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism
DNA:SNPs: :-1195A > G, -765G > C (human)
DNA:polymorphisms: :-1195A>A ,-765G>C (human)

CTD
RGD

PMID:10485483 PMID:10657949 PMID:15705899 PMID:16820089 PMID:19820419 More...

RGD:2317179, RGD:5135527, RGD:2317175, RGD:2317184

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone-like hormone

CTD Direct Evidence: marker/mechanism

NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:180,188,792...180,199,847

G

RAB, member of RAS oncogene family-like 3

susceptibility

ClinVar Annotator: match by term: Pancreatic cancer, susceptibility to, 5 | ClinVar Annotator: match by term: RABL3-related condition
CTD Direct Evidence: marker/mechanism

ClinVar
CTD
OMIM

NCBI chr11:63,153,281...63,182,240
Ensembl chr11:63,152,792...63,182,671

G

RAD51 recombinase

protein:increased expression:pancreas (rat)

RGD

NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:106,100,381...106,125,035

G

RAD54 like

DNA:SNP:exon:rs1048771 (human)

RGD

NCBI chr 5:134,812,158...134,841,821
Ensembl chr 5:129,575,378...129,605,070

G

Rap1 GTPase-activating protein

mRNA:decreased expression:pancreas (human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:22614916 PMID:16424023

NCBI chr 5:155,157,511...155,222,622
Ensembl chr 5:149,892,019...149,939,253

G

RB transcriptional corepressor 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302

G

RecQ like helicase

DNA:SNPs:introns
DNA:SNP:3'utr:rs13035 (human)

RGD

PMID:18422747 PMID:19768149 PMID:16540687

RGD:2317370, RGD:2317369, RGD:2317365

NCBI chr 4:177,039,351...177,063,968
Ensembl chr 4:175,304,117...175,332,945

G

RELA proto-oncogene, NF-kB subunit

RGD

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

ret proto-oncogene

disease_progression

protein:increased expression:pancreas

RGD

NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:151,326,431...151,368,176

G

rhomboid domain containing 1

CTD Direct Evidence: therapeutic

NCBI chr 9:91,076,786...91,196,719
Ensembl chr 9:83,630,063...83,748,689

G

ribonucleotide reductase regulatory subunit M2

RGD

NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:41,340,557...41,346,773

G

RUNX family transcription factor 3

disease_progression

DNA:hypermethylation, loss of heterozygosity (human)

RGD

NCBI chr 5:152,644,270...152,702,835
Ensembl chr 5:147,360,994...147,419,156

G

retinoid X receptor alpha

RGD

NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:10,989,832...11,073,712

G

SEL1L adaptor subunit of SYVN1 ubiquitin ligase

RGD

NCBI chr 6:116,466,163...116,510,436
Ensembl chr 6:110,735,450...110,779,648

G

serpin family A member 1

disease_progression

RGD

NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:122,866,312...122,888,339

G

splicing factor 3B subunit 4

mRNA, protein:decreased expression:pancreas (human)

RGD

NCBI chr 2:186,421,667...186,426,419
Ensembl chr 2:183,732,754...183,737,959

G

sonic hedgehog signaling molecule

RGD

NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:6,954,017...6,963,170

G

SIN3-HDAC complex associated factor

CTD Direct Evidence: marker/mechanism

NCBI chr 4:181,888,301...181,913,294
Ensembl chr 4:181,888,312...181,910,276

G

solute carrier family 1 member 5

CTD Direct Evidence: marker/mechanism

NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 29 member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:22,897,099...22,911,640
Ensembl chr 9:15,399,612...15,414,203

G

solute carrier organic anion transporter family, member 2b1

mRNA:decreased expression:pancreas (human)

RGD

NCBI chr 1:163,371,410...163,419,412
Ensembl chr 1:153,959,293...154,007,353

G

SMAD family member 2

mRNA:increased expression:pancreas (human)

RGD

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 3

DNA:mutations:exon

RGD

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960

G

SMAD family member 4

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Cancer of the pancreas
DNA:mutations:exon

OMIM
CTD
ClinVar
RGD

PMID:25741868 PMID:18772397

NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438

G

SMAD family member 7

mRNA:increased expression:pancreas (human)

RGD

NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4

RGD

NCBI chr 8:28,438,370...28,535,071
Ensembl chr 8:20,167,717...20,258,975

G

smoothened, frizzled class receptor

treatment

protein:increased expression:pancreas

RGD

PMID:19460966 PMID:22859707 PMID:19396459

RGD:2324978, RGD:150340554, RGD:2324910

NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:58,343,529...58,373,829

G

SMAD specific E3 ubiquitin protein ligase 1

RGD

NCBI chr12:14,748,717...14,840,273
Ensembl chr12:9,635,025...9,726,519

G

synuclein, gamma

RGD

NCBI chr16:9,706,765...9,712,072
Ensembl chr16:9,700,514...9,705,368

G

SNW domain containing 1

susceptibility

DNA:snp:intron: T>A (human) (rs1477261)

RGD

NCBI chr 6:112,826,374...112,850,459
Ensembl chr 6:107,095,457...107,119,536

G

superoxide dismutase 1

protein:decreased expression:pancreas

RGD

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

disease_progression
susceptibility

protein:decreased expression:pancreas
CTD Direct Evidence: marker/mechanism
DNA:polymorphism:cds:p.A16V (human)

CTD
RGD

PMID:11328670 PMID:17895890 PMID:12499913 PMID:12700280 PMID:18205184

RGD:2317410, RGD:1581235, RGD:2317406

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

serine peptidase inhibitor, Kazal type 1

CTD Direct Evidence: marker/mechanism

NCBI chr18:36,121,626...36,133,596
Ensembl chr18:35,824,550...35,882,642

G

secreted phosphoprotein 1

RGD

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162

G

somatostatin

CTD Direct Evidence: therapeutic

NCBI chr11:90,461,546...90,462,823
Ensembl chr11:76,956,896...76,958,173

G

somatostatin receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:81,567,237...81,571,759
Ensembl chr 6:75,832,530...75,836,802

G

somatostatin receptor 2

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:15259086 PMID:17625444 PMID:19917848

NCBI chr10:99,163,353...99,170,519
Ensembl chr10:98,664,216...98,674,351

G

somatostatin receptor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 7:111,973,049...111,980,250
Ensembl chr 7:110,092,575...110,099,769

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

PMID:22348037 PMID:23845849

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

serine/threonine kinase 11

CTD Direct Evidence: marker/mechanism

NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:9,575,269...9,591,315

G

succinylCoA:glutarate-CoA transferase

CTD Direct Evidence: marker/mechanism

NCBI chr17:52,072,012...52,929,852
Ensembl chr17:47,376,521...48,234,376

G

synaptonemal complex protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:192,985,164...193,145,234
Ensembl chr 2:190,296,954...190,456,737

G

transcription factor 7 like 2

DNA:mutations:exon

RGD

NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:254,786,091...254,978,967

G

telomerase reverse transcriptase

CTD Direct Evidence: marker/mechanism

PMID:25086665 PMID:26098869

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561

G

tissue factor pathway inhibitor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 4:32,936,462...32,941,385
Ensembl chr 4:31,982,178...31,986,600

G

transforming growth factor alpha

mRNA, protein:increased expression:pancreas

RGD

PMID:1401070 PMID:19506583 PMID:17785207

RGD:2317473, RGD:5490965, RGD:2317468

NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

disease_progression

CTD Direct Evidence: marker/mechanism
protein:increased expression:serum

CTD
RGD

PMID:23992306 PMID:18787407 PMID:16933058

RGD:2325015, RGD:2325018

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 2

disease_progression

DNA:deletion, frameshift mutations (human)
DNA:mutations:exon
protein:increased expresssion:pancreas
mRNA:increased expresssion:pancreas

RGD

PMID:9850059 PMID:18772397 PMID:11866987 PMID:9365135

RGD:2317501, RGD:5490966, RGD:2317499, RGD:2317502

NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228

G

transglutaminase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 3:167,192,612...167,221,845
Ensembl chr 3:146,772,687...146,801,981

G

thrombospondin 1

disease_progression

DNA:hypermethylation (human)

RGD

PMID:10766168 PMID:20203415 PMID:16757110

RGD:2325028, RGD:2325021, RGD:2325023

NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:105,056,292...105,071,440

G

tumor necrosis factor

CTD Direct Evidence: therapeutic

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 10

CTD Direct Evidence: therapeutic

NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135

G

tumor protein p53

DNA:mutations:exon
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:23873029 PMID:26390243 PMID:18772397

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p53 binding protein 1

RGD

NCBI chr 3:128,620,320...128,724,716
Ensembl chr 3:108,169,980...108,269,822

G

tumor protein p63

CTD Direct Evidence: marker/mechanism

NCBI chr11:88,343,647...88,554,543
Ensembl chr11:74,838,859...75,049,398

G

TSC complex subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:14,125,679...14,160,317
Ensembl chr10:13,621,136...13,655,951

G

thymidine phosphorylase

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17443278 PMID:19671868

NCBI chr 7:122,318,396...122,323,716
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874

G

thymidylate synthetase

CTD Direct Evidence: marker/mechanism

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536

G

uridine-cytidine kinase 2

protein:increased expression:pancreatic neoplasm (human)

RGD

NCBI chr13:81,913,732...81,971,036
Ensembl chr13:79,383,846...79,438,352

G

UDP glucuronosyltransferase 1 family, polypeptide A7C

no_association

DNA:polymorphisms: :p.N129K, p.R131K, p.W208R (human)
DNA:polymorphisms: :multiple (human)

RGD

PMID:12806614 PMID:17072959

RGD:2317503, RGD:2317157

NCBI chr 9:96,187,382...96,256,264
Ensembl chr 9:88,713,184...88,808,465

G

vascular cell adhesion molecule 1

RGD

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor B

CTD Direct Evidence: marker/mechanism

NCBI chr 1:213,601,570...213,607,254
Ensembl chr 1:204,172,225...204,177,944

G

von Hippel-Lindau tumor suppressor

DNA:hypermethylation, deletion:promoter (human)
associated with Hippel-Lindau Disease;DNA:missense mutation:exon:p.R238Q (human)

RGD

PMID:19690016 PMID:9488521

RGD:2325169, RGD:2325176

NCBI chr 4:148,328,099...148,334,992
Ensembl chr 4:146,772,468...146,779,377

G

Wnt family member 9A

DNA:mutations:exon

RGD

NCBI chr10:44,593,691...44,620,682
Ensembl chr10:44,094,140...44,121,133

G

WT1 transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:91,567,001...91,613,643

G

XPC complex subunit, DNA damage recognition and repair factor

DNA:polymorphism:intron:AF076952 (human)

RGD

NCBI chr 4:125,550,833...125,578,084
Ensembl chr 4:123,993,666...124,021,010

G

exportin 1

exacerbates

protein:increased expression:pancreas (human)

RGD

NCBI chr14:101,434,450...101,476,705
Ensembl chr14:97,233,270...97,275,498

G

exportin 5

mRNA:decreased expression:pancreas (mouse)

RGD

NCBI chr 9:22,237,760...22,275,745
Ensembl chr 9:14,740,182...14,778,171

G

X-ray repair cross complementing 1

DNA:SNP:exon:rs1799782 (human)

RGD

NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:80,141,207...80,168,701

G

X-ray repair cross complementing 2

DNA:polymorphism: :p.R188H (human)
DNA:SNP:exon:rs3218536 (human)

RGD

PMID:17986315 PMID:16540687

RGD:2317507, RGD:2317365

NCBI chr 4:10,157,130...10,237,089
Ensembl chr 4:9,423,898...9,442,482

G

X-ray repair cross complementing 3

DNA:SNP:cd:rs861539 (human)

RGD

NCBI chr 6:136,684,558...136,694,822
Ensembl chr 6:130,863,959...130,872,444

G

zinc and ring finger 3

CTD Direct Evidence: marker/mechanism

PMID:25086665 PMID:26098869

NCBI chr14:84,375,668...84,527,465
Ensembl chr14:80,160,278...80,313,485

pancreatic carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activin A receptor type 1B

ClinVar Annotator: match by term: Carcinoma of pancreas

NCBI chr 7:134,164,987...134,208,389
Ensembl chr 7:132,286,275...132,329,673

G

ATM serine/threonine kinase

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:988733 PMID:1849795 PMID:3338800 PMID:8808599 PMID:9443866 More...

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437

G

BRCA1, DNA repair associated

ClinVar Annotator: match by term: Carcinoma of head of pancreas | ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:9150174 PMID:10667592 PMID:10667595 PMID:11802209 PMID:12566964 More...

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304

G

BRCA2, DNA repair associated

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8665505 PMID:9150150 PMID:9361038 PMID:9536098 PMID:9585613 More...

NCBI chr12:4,895,092...4,939,340
Ensembl chr12:59,819...100,567

G

BRCA1 interacting DNA helicase 1

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:16116423 PMID:17033622 PMID:21964575 PMID:25330149 PMID:25741868 More...

NCBI chr10:71,402,035...71,528,083
Ensembl chr10:70,907,371...71,030,324

G

similar to human chromosome 11 open reading frame 65

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:988733 PMID:1849795 PMID:3338800 PMID:8808599 PMID:9443866 More...

NCBI chr 8:62,692,123...62,720,951
Ensembl chr 8:53,796,366...53,824,748

G

carbonyl reductase 4

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:17194196 PMID:25741868 PMID:28492532

NCBI chr16:33,625,734...33,695,067
Ensembl chr16:28,617,224...28,645,712

G

cyclin-dependent kinase inhibitor 1A

RGD

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

susceptibility

DNA:insertion:cds:p.R112_L113insR (human)

RGD

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149

G

chromodomain helicase DNA binding protein 3

disease_progression

protein:increased expression:pancreas

RGD

NCBI chr10:54,562,437...54,588,842
Ensembl chr10:54,063,629...54,090,047

G

checkpoint kinase 2

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:9536098 PMID:10617473 PMID:11053450 PMID:11479205 PMID:11719428 More...

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286

G

ERCC excision repair 4, endonuclease catalytic subunit

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8797827 PMID:9579555 PMID:20221251 PMID:21228398 PMID:21612988 More...

NCBI chr10:2,926,085...2,958,176
Ensembl chr10:2,419,038...2,448,369
Ensembl chr10:2,419,038...2,448,369

G

FA complementation group E

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:11001585 PMID:17924555 PMID:21279724 PMID:25741868 PMID:26822949 More...

NCBI chr20:6,369,416...6,386,631
Ensembl chr20:6,375,573...6,386,631

G

FA complementation group G

ClinVar Annotator: match by term: Carcinoma of pancreas

NCBI chr 5:62,027,494...62,037,202
Ensembl chr 5:57,231,685...57,240,029

G

heterogeneous nuclear ribonucleoprotein A2/B1

severity

protein:increased expression:pancreas (rat)

RGD

NCBI chr 4:81,867,354...81,875,886
Ensembl chr 4:80,534,651...80,545,249

G

homeo box B13

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8756292 PMID:15964834 PMID:17138648 PMID:22236224 PMID:22714738 More...

NCBI chr10:81,657,074...81,659,347
Ensembl chr10:81,160,498...81,162,777

G

kinase insert domain receptor

treatment

RGD

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018

G

KRAS proto-oncogene, GTPase

OMIM:260350
ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

MouseDO
ClinVar

PMID:1875403 PMID:7773929 PMID:8439212 PMID:12110640 PMID:12720172 More...

NCBI chr 4:179,916,255...179,949,613

G

microRNA 155

miRNA:increased expression:serum

RGD

NCBI chr11:37,261,114...37,261,178
Ensembl chr11:23,774,654...23,774,718

G

mechanistic target of rapamycin kinase

treatment

RGD

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

MYC proto-oncogene, bHLH transcription factor

OMIM:260350

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

G

nibrin

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:9590180 PMID:9590181 PMID:9620777 PMID:10398434 PMID:10799436 More...

NCBI chr 5:34,256,678...34,291,163
Ensembl chr 5:29,459,457...29,494,150

G

partner and localizer of BRCA2

ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:17200668 PMID:17200671 PMID:17200672 PMID:20122277 PMID:20412113 More...

NCBI chr 1:186,096,312...186,120,284
Ensembl chr 1:176,665,076...176,688,990

G

palladin, cytoskeletal associated protein

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:17194196 PMID:25741868 PMID:28492532

NCBI chr16:33,238,943...33,632,236
Ensembl chr16:27,981,354...28,621,337

G

DNA polymerase delta 1, catalytic subunit

ClinVar Annotator: match by term: Carcinoma of pancreas

NCBI chr 1:104,161,984...104,178,074
Ensembl chr 1:95,025,499...95,036,465

G

Raf-1 proto-oncogene, serine/threonine kinase

mRNA:increased expression:pancreas (rat)

RGD

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317

G

RB binding protein 8, endonuclease

ClinVar Annotator: match by term: Carcinoma of pancreas

PMID:9811458 PMID:28492532

NCBI chr18:3,198,188...3,263,643
Ensembl chr18:2,921,286...2,988,846

G

SMAD family member 4

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:8653691 PMID:9582123 PMID:9811934 PMID:10398437 PMID:10764709 More...

NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438

G

serine/threonine kinase 11

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:10362809 PMID:11430832 PMID:15188174 PMID:15800014 PMID:16287113 More...

NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:9,575,269...9,591,315

G

tumor protein p53

ClinVar Annotator: match by term: Carcinoma of pancreas | ClinVar Annotator: match by term: PANCREATIC CARCINOMA

PMID:1565143 PMID:1565144 PMID:1581912 PMID:1591732 PMID:1631137 More...

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

TSC complex subunit 1

RGD

NCBI chr 3:32,367,434...32,416,565
Ensembl chr 3:11,979,729...12,015,674

pancreatic ductal adenocarcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

anterior gradient 2, protein disulphide isomerase family member

protein:increased expression:pancreas

RGD

NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371

G

aldo-keto reductase family 7, member A2

protein:increased expression:pancreas

RGD

NCBI chr 5:156,835,589...156,844,127
Ensembl chr 5:151,552,343...151,560,909

G

calreticulin

ameliorates

human cells in mouse model
human cells in a mouse model

RGD

PMID:33028359 PMID:29072694

RGD:150520160, RGD:150521706

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414

G

cyclin D1

severity

DNA:snp:exon:c.870G>A (human)
protein:increased expression:pancreas (human)

RGD

PMID:25470788 PMID:22939953

RGD:13462050, RGD:13462062

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

CD59b molecule

disease_progression

protein:increased expression:blood (human)

RGD

NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847

G

cyclin-dependent kinase 4

severity

protein:increased expression:pancreas, islet of Langerhans (human)

RGD

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403

G

E2F transcription factor 1

severity

protein:increased expression:pancreatic ductal cell, nucleus (human)
DNA:amplification: : (human)

RGD

PMID:12650514 PMID:17233815 PMID:27573434

RGD:13838735, RGD:13838739, RGD:13838738

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361

G

forkhead box M1

disease_progression

RGD

NCBI chr 4:163,325,628...163,338,100
Ensembl chr 4:161,638,816...161,650,684

G

far upstream element binding protein 1

mRNA:increased expression:pancreatic duct (human)

RGD

NCBI chr 2:243,819,529...243,846,544
Ensembl chr 2:241,159,512...241,186,602

G

GLI pathogenesis-related 2

disease_progression

protein:decreased expression:blood (human)

RGD

NCBI chr 5:62,966,163...62,998,016
Ensembl chr 5:58,170,425...58,202,272

G

glutamic-oxaloacetic transaminase 1

treatment

human cells in a mouse model

RGD

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633

G

heat shock protein family A (Hsp70) member 8

disease_progression

protein:decreased expression:blood (human)

RGD

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259

G

inhibitor of nuclear factor kappa B kinase subunit beta

susceptibility

RGD

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250

G

Janus kinase 1

mRNA:decreased expression:pancreatic ductal cell (human)

RGD

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:115,780,248...115,888,926

G

mitogen-activated protein kinase 8

severity
disease_progression

protein:increased phosphorylation:pancreas (mouse)

RGD

PMID:28837246 PMID:23237571

RGD:14348974, RGD:14348975

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

G

microRNA 155

disease_progression

RGD

NCBI chr11:37,261,114...37,261,178
Ensembl chr11:23,774,654...23,774,718

G

microRNA 494

disease_progression
ameliorates

RGD

PMID:24859161 PMID:24859161

RGD:156430321, RGD:156430321

NCBI chr 6:134,550,115...134,550,197
Ensembl chr 6:128,728,709...128,728,793

G

placental growth factor

severity

associated with obesity

RGD

NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:104,816,104...104,826,685

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

mRNA, protein:increased expression:pancreas (human)

RGD

NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043

G

phosphoinositide-3-kinase regulatory subunit 2

severity

human cells in a mouse model

RGD

NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,665,457...18,674,065

G

phospholipase D1

severity

protein:increased expression:pancreas (human)

RGD

NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:110,893,608...111,047,692

G

protein tyrosine phosphatase, receptor type, B

disease_progression

protein:decreased expression:blood (human)

RGD

NCBI chr 7:53,816,197...53,920,760
Ensembl chr 7:51,930,015...52,034,748

G

protein tyrosine phosphatase, receptor type, M

disease_progression

protein:decreased expression:blood (human)

RGD

NCBI chr 9:114,086,380...114,791,000
Ensembl chr 9:106,639,573...107,343,698

G

Rac family small GTPase 1

mRNA:increased expression:pancreas (human)
mRNA, protein:increased expression:pancreas (mouse)

RGD

PMID:23334332 PMID:21684285

RGD:14392806, RGD:14392816

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251

G

RAS like proto-oncogene A

mRNA:increased expression:pancreas (human)

RGD

NCBI chr17:51,787,682...51,840,738
Ensembl chr17:47,092,207...47,144,063

G

S100 calcium binding protein A8

disease_progression

protein:increased expression:blood (human)

RGD

NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:176,167,124...176,167,643

G

SMAD family member 2

severity

RGD

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323

G

transforming growth factor, beta 1

ameliorates

protein:decreased expression:pancreas (human)

RGD

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

ameliorates

protein:decreased expression:pancreas (human)

RGD

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405

G

transforming growth factor, beta 3

ameliorates

protein:decreased expression:pancreas (human)

RGD

NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:105,704,236...105,726,564

G

transforming growth factor, beta receptor 1

ameliorates

human cell line in a mouse model

RGD

NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777

G

vascular endothelial growth factor D

protein:increased expression:blood serum (human)

RGD

NCBI chr X:33,704,582...33,740,305
Ensembl chr X:30,074,163...30,108,295

G

vanin 1

disease_progression

protein:increased expression:blood (human)

RGD

NCBI chr 1:23,356,324...23,366,629
Ensembl chr 1:21,537,094...21,547,395

pancreatic ductal carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

mRNA, protein:increased expression:pancreas

RGD

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

protein:decreased expression:pancreas

RGD

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:30,293,589...30,340,977

G

ADAM metallopeptidase domain 8

disease_progression

mRNA:increased expression:pancreas

RGD

NCBI chr 1:204,206,206...204,218,988
Ensembl chr 1:194,770,060...194,788,801

G

ADAM metallopeptidase domain 9

disease_progression

protein:altered localization:cytoplasm

RGD

NCBI chr16:73,725,186...73,804,284
Ensembl chr16:67,022,655...67,100,917

G

anterior gradient 2, protein disulphide isomerase family member

mRNA:increased expression:pancreas

RGD

NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371

G

angiotensin II receptor, type 1a

CTD Direct Evidence: marker/mechanism

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946

G

albumin

disease_progression

RGD

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

annexin A2

disease_progression

mRNA, protein:increased expression, altered localization:pancreas, plasma membrane

RGD

PMID:19260470 PMID:16450333

RGD:2317307, RGD:2325731

NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:70,105,253...70,141,658

G

annexin A5

protein:increased expression:pancreas

RGD

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:119,314,007...119,353,369

G

annexin A8

mRNA:increased expression:pancreas

NCBI chr16:9,397,144...9,412,072
Ensembl chr16:9,397,113...9,412,043

G

apolipoprotein C1

RGD

NCBI chr 1:88,475,018...88,479,052
Ensembl chr 1:79,346,136...79,350,375

G

arginase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:97,936,002...97,961,378

G

BMI1 proto-oncogene, polycomb ring finger

protein:increased expression:pancreas
protein:increased expression:exocrine pancreas:

RGD

PMID:19585519 PMID:19585519

RGD:9491843, RGD:9491843

NCBI chr17:86,240,683...86,250,044
Ensembl chr17:81,332,214...81,388,690

G

similar to human chromosome 19 open reading frame 33

CTD Direct Evidence: marker/mechanism

NCBI chr 1:84,549,830...84,550,666
Ensembl chr 1:84,549,831...84,550,664

G

calreticulin

protein:increased expression:pancreatic duct

RGD

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414

G

chromobox 7

disease_progression

protein:decreased expression:pancreas

RGD

NCBI chr 7:113,341,030...113,358,716
Ensembl chr 7:111,460,656...111,477,973

G

cholecystokinin A receptor

mRNA:increased expression:pancreatic duct
protein:decreased expression:pancreas

RGD

PMID:9239407 PMID:12851875

RGD:4110818, RGD:4110816

NCBI chr14:61,505,270...61,513,618
Ensembl chr14:57,292,397...57,300,747

G

cholecystokinin B receptor

protein:decreased expression:pancreas

RGD

NCBI chr 1:169,183,578...169,193,583
Ensembl chr 1:159,771,733...159,814,881

G

cyclin D1

severity

protein:increased expression:pancreas (human)

RGD

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

CD40 molecule

treatment

protein:increased expression:dendritic cell

RGD

PMID:21436454 PMID:23983255 PMID:20976171

RGD:5490301, RGD:11522743, RGD:5490524

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534

G

cyclin-dependent kinase 6

treatment

human cells in a mouse model

RGD

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 1A

disease_progression

RGD

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

CTD Direct Evidence: marker/mechanism

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149

G

claudin 4

RGD

NCBI chr12:27,388,160...27,389,958
Ensembl chr12:21,751,331...21,753,436

G

C-X-C motif chemokine ligand 11

CTD Direct Evidence: marker/mechanism

NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,689,424...15,692,271

G

DNA methyltransferase 1

disease_progression

protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:29844410 PMID:19424621

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659

G

DNA methyltransferase 3 beta

disease_progression

RGD

NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:142,130,592...142,169,124

G

deltex E3 ubiquitin ligase 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:41,510,252...41,541,433
Ensembl chr12:35,849,617...35,880,838

G

deltex E3 ubiquitin ligase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 1:218,882,391...218,969,837
Ensembl chr 1:209,460,735...209,492,818

G

epidermal growth factor

disease_progression

protein:increased expression: :

RGD

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064

G

Fas ligand

protein:increased expression:pancreas, liver

RGD

PMID:10547193 PMID:15375495

RGD:2317747, RGD:2317741

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215

G

fibroblast growth factor 2

disease_progression

RGD

PMID:12717266 PMID:18704599

RGD:2317758, RGD:2317756

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221

G

fascin actin-bundling protein 1

disease_progression

protein:increased expression:pancreas

RGD

NCBI chr12:16,710,601...16,723,734
Ensembl chr12:11,597,048...11,610,211

G

glycoprotein nmb

CTD Direct Evidence: marker/mechanism

NCBI chr 4:79,341,128...79,362,366
Ensembl chr 4:78,010,197...78,049,367

G

glutathione S-transferase pi 1

resistance

DNA:methylation: :
mRNA, protein:increased expression:pancreas

RGD

PMID:16537562 PMID:17265526 PMID:12488200

RGD:2317809, RGD:2317806, RGD:2317811

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226

G

histone deacetylase 1

disease_progression

protein:increased expression:pancreas

RGD

NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:141,853,989...141,881,111

G

HEAT repeat containing 1

treatment

RGD

NCBI chr17:62,745,008...62,785,609
Ensembl chr17:58,051,700...58,093,948

G

hes family bHLH transcription factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:84,210,632...84,213,045
Ensembl chr11:70,705,764...70,708,192

G

hes-related family bHLH transcription factor with YRPW motif 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:93,095,498...93,100,312

G

hes-related family bHLH transcription factor with YRPW motif 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:28,641,100...28,651,187
Ensembl chr 1:26,822,131...26,832,218

G

heat shock protein family A (Hsp70) member 1A

CTD Direct Evidence: marker/mechanism

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

CTD Direct Evidence: marker/mechanism

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

insulin-like growth factor 1

RGD

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

protein:increased expression:pancreas

RGD

PMID:14627343 PMID:14506643

RGD:2317649, RGD:2317652

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777

G

interleukin 4

RGD

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

interleukin 4 receptor

protein:increased expression:pancreas

RGD

NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:180,115,120...180,139,980

G

insulin 2

Glucagon/insulin

RGD

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775

G

jagged canonical Notch ligand 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:124,406,794...124,442,209

G

jagged canonical Notch ligand 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:137,804,133...137,826,738
Ensembl chr 6:131,983,056...132,005,818

G

lysine demethylase 2B

severity

mRNA, protein:increased expression:pancreas (human)

RGD

NCBI chr12:39,224,422...39,362,126
Ensembl chr12:33,574,657...33,701,355

G

KIT ligand

CTD Direct Evidence: marker/mechanism

NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:34,896,053...34,977,214

G

KRAS proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism

PMID:25347530 PMID:30654191

NCBI chr 4:179,916,255...179,949,613

G

keratin 7

disease_progression

RGD

NCBI chr 7:134,407,626...134,423,787
Ensembl chr 7:132,528,895...132,545,052

G

L1 cell adhesion molecule

severity

protein:increased expression:pancreas (human)

RGD

NCBI chr X:156,748,597...156,775,116
Ensembl chr X:151,597,277...151,623,857

G

mitogen activated protein kinase kinase kinase 7

CTD Direct Evidence: marker/mechanism

NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597

G

mitogen activated protein kinase 3

treatment

human cells in mouse model

RGD

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

minichromosome maintenance complex component 7

mRNA, protein:increased expression:pancreatic duct

RGD

NCBI chr12:22,155,921...22,163,320
Ensembl chr12:17,042,212...17,050,063

G

MDM2 proto-oncogene

onset
severity

DNA:snp:promoter, intron:IVS1+309T>G (human)
protein:increased expression:pancreas (human)

RGD

PMID:19752772 PMID:15810085

RGD:2317414, RGD:2317416

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915

G

menin 1

protein:decreased expression:pancreas

RGD

NCBI chr 1:213,068,166...213,074,132
Ensembl chr 1:203,639,000...203,644,871

G

MET proto-oncogene, receptor tyrosine kinase

protein:increased expression:pancreatic duct (human)

RGD

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876

G

O-6-methylguanine-DNA methyltransferase

susceptibility

DNA:missense mutation:cds:p.L84F rs12917 (human)
protein:increased activity, increased expression:ductal adenocarcinoma (human)

RGD

PMID:16844323 PMID:9393761

RGD:2317648, RGD:2317664

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756

G

microRNA 142

CTD Direct Evidence: marker/mechanism

NCBI chr10:73,055,104...73,055,190
Ensembl chr10:72,557,857...72,557,967

G

microRNA 873

CTD Direct Evidence: therapeutic

NCBI chr 5:56,153,104...56,153,180
Ensembl chr 5:51,356,919...51,356,995

G

matrix metallopeptidase 2

severity

protein:increased expression:pancreas

RGD

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

protein:increased expression:pancreas, serum
protein:increased expression:blood

RGD

PMID:18706098 PMID:20332475

RGD:2325844, RGD:2325830

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

mesothelin

disease_progression

protein:increased secretion:serum
CTD Direct Evidence: marker/mechanism
DNA:hypomethylation:5'UTR

CTD
RGD

PMID:14576474 PMID:21775916 PMID:25347530 PMID:19818733 PMID:12874021

RGD:2326055, RGD:2326065

NCBI chr10:15,276,489...15,285,921
Ensembl chr10:14,771,961...14,777,643

G

mucin 1, cell surface associated

disease_progression

protein:increased expression, altered localization:pancreas

RGD

PMID:14681945 PMID:19109152 PMID:18713982

RGD:2317983, RGD:2324616, RGD:2324633

NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:174,635,995...174,640,733

G

mucin 17, cell surface associated

disease_progression

mRNA:increased expression:pancreas

RGD

NCBI chr12:25,139,076...25,175,249
Ensembl chr12:19,527,321...19,538,522

G

mucin 3A, cell surface associated

disease_progression

mRNA:increased expression:pancreas

NCBI chr12:19,450,679...19,454,753
Ensembl chr12:19,446,094...19,460,522

G

mucin 4, cell surface associated

disease_progression

mRNA:increased expression:pancreas
protein:increased expression:pancreas

RGD

PMID:12657964 PMID:16049287

RGD:2324946, RGD:2324942

NCBI chr11:81,513,321...81,575,200

G

mucin 5AC, oligomeric mucus/gel-forming

disease_progression

mRNA:increased expression:pancreas

RGD

PMID:7657125 PMID:10227724

RGD:2324986, RGD:2324907

NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:196,864,336...196,896,475

G

mucin 5B, oligomeric mucus/gel-forming

mRNA:increased expression:pancreas

RGD

NCBI chr 1:206,346,400...206,378,367
Ensembl chr 1:196,916,825...196,949,250

G

N-myc downstream regulated 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:98,684,487...98,725,880

G

NFE2 like bZIP transcription factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

NME/NM23 nucleoside diphosphate kinase 1

protein:increased expression:pancreas (human)

RGD

NCBI chr10:79,403,939...79,426,620
Ensembl chr10:78,906,083...78,916,408

G

nitric oxide synthase 2

RGD

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 1

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:19208345 PMID:20484026 PMID:19028876

RGD:2325323, RGD:2325324

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531

G

notch receptor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 7:11,783,550...11,834,585
Ensembl chr 7:11,133,706...11,184,025

G

notch receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr20:4,164,969...4,189,072
Ensembl chr20:4,160,445...4,184,465

G

neurotrophic receptor tyrosine kinase 3

disease_progression

protein:increased expression:pancreas

RGD

PMID:11295066 PMID:10209957

RGD:2325660, RGD:2325663

NCBI chr 1:141,526,192...141,913,575
Ensembl chr 1:132,132,849...132,503,286

G

oncostatin M

CTD Direct Evidence: marker/mechanism

NCBI chr14:83,327,202...83,332,073
Ensembl chr14:79,104,344...79,108,313

G

palladin, cytoskeletal associated protein

protein:increased expression, alternative form:pancreas, fibroblast

RGD

NCBI chr16:33,238,943...33,632,236
Ensembl chr16:27,981,354...28,621,337

G

paired box 6

protein:increased expression:pancreatic duct (human)

RGD

NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:92,135,637...92,157,014

G

PMS1 homolog 1, mismatch repair system component

protein:increased expression:pancreatic duct

RGD

NCBI chr 9:55,721,393...55,832,225
Ensembl chr 9:48,253,410...48,340,237

G

peroxisome proliferator-activated receptor gamma

disease_progression

RGD

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin-endoperoxide synthase 2

RGD

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

ring finger protein 2

protein:increased expression:pancreas

RGD

NCBI chr13:66,103,943...66,136,038
Ensembl chr13:63,554,862...63,583,099

G

retinoid X receptor alpha

severity

RGD

NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:10,989,832...11,073,712

G

serpin family A member 1

mRNA, protein:increased expression:pancreas

RGD

NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:122,866,312...122,888,339

G

solute carrier family 2 member 2

protein:increased expression:pancreatic duct

RGD

NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:111,611,774...111,639,933

G

SMAD family member 4

disease_progression

RGD

NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438

G

smoothened, frizzled class receptor

RGD

NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:58,343,529...58,373,829

G

serine/threonine kinase 11

CTD Direct Evidence: marker/mechanism

NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:9,575,269...9,591,315

G

transforming growth factor, beta 1

disease_progression

RGD

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 2

disease_progression

mRNA:increased expresssion:pancreas

RGD

PMID:17114585 PMID:10547197

RGD:2317498, RGD:2317500

NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228

G

thrombospondin 1

disease_progression

DNA:hypermethylation:promoter (human)

RGD

PMID:12429967 PMID:19065635

RGD:2325025, RGD:2325022

NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:105,056,292...105,071,440

G

transmembrane serine protease 3

RGD

NCBI chr20:9,253,497...9,275,167
Ensembl chr20:9,254,109...9,274,363

G

tumor protein p53

CTD Direct Evidence: marker/mechanism

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

TSC complex subunit 2

severity

RGD

NCBI chr10:14,125,679...14,160,317
Ensembl chr10:13,621,136...13,655,951

G

thymidine phosphorylase

disease_progression

RGD

NCBI chr 7:122,318,396...122,323,716
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874

G

vascular endothelial growth factor A

CTD Direct Evidence: marker/mechanism

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

G

von Hippel-Lindau tumor suppressor

DNA:hypermethylation:promoter (human)

RGD

NCBI chr 4:148,328,099...148,334,992
Ensembl chr 4:146,772,468...146,779,377

G

YEATS domain containing 2

CTD Direct Evidence: marker/mechanism

NCBI chr11:94,247,538...94,333,652
Ensembl chr11:80,743,134...80,829,208

G

zinc finger, ZZ-type containing 3

CTD Direct Evidence: marker/mechanism

NCBI chr 2:243,990,305...244,057,251
Ensembl chr 2:241,331,022...241,397,307

pancreatic endocrine carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BRCA2, DNA repair associated

ClinVar Annotator: match by term: Neuroendocrine tumor of pancreas

PMID:15145354 PMID:22762150 PMID:25741868 PMID:29446198

NCBI chr12:4,895,092...4,939,340
Ensembl chr12:59,819...100,567

G

cut-like homeobox 1

exacerbates

protein:increased expression:pancreas (human)

NCBI chr12:25,728,393...26,062,497
Ensembl chr12:20,107,311...20,425,866
Ensembl chr 4:20,107,311...20,425,866

G

death-domain associated protein

disease_progression

DNA:frameshift, frameshift mutations, nonsense mutation, missense mutations:CDS:multiple (human)

RGD

NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,970,092...4,975,843

G

O-6-methylguanine-DNA methyltransferase

DNA:hypermethylation:promoter (human)

RGD

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756

G

partner and localizer of BRCA2

ClinVar Annotator: match by term: Neuroendocrine tumor of pancreas

PMID:17200668 PMID:17200671 PMID:17200672 PMID:24136930 PMID:25099575 More...

NCBI chr 1:186,096,312...186,120,284
Ensembl chr 1:176,665,076...176,688,990

G

placental growth factor

disease_progression
treatment

protein:increased expression:serum (human)
human cells in a mouse model

RGD

PMID:23463017 PMID:26861455

RGD:14349029, RGD:14349030

NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:104,816,104...104,826,685

pancreatic intraductal papillary-mucinous neoplasm

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

DNA:missense mutation:cds:p.E17K (human)

RGD

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

tumor protein p53

DNA:missense mutations: :multiple

RGD

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

vascular endothelial growth factor D

protein:increased expression:blood serum (human)

RGD

NCBI chr X:33,704,582...33,740,305
Ensembl chr X:30,074,163...30,108,295

Pancreatic Intraepithelial Neoplasia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

anterior gradient 2, protein disulphide isomerase family member

protein:increased expression:pancreas

RGD

NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371

G

BMI1 proto-oncogene, polycomb ring finger

protein:increased expression:pancreatic acinar cell:
protein:increased expression:exocrine pancreas:

RGD

PMID:19585519 PMID:19585519

RGD:9491843, RGD:9491843

NCBI chr17:86,240,683...86,250,044
Ensembl chr17:81,332,214...81,388,690

G

chromobox 7

disease_progression

protein:decreased expression:pancreas

RGD

NCBI chr 7:113,341,030...113,358,716
Ensembl chr 7:111,460,656...111,477,973

G

cyclin D1

disease_progression

protein:increased expression:pancreas (human)

RGD

PMID:12882690 PMID:11751405

RGD:13462061, RGD:13464129

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

DNA methyltransferase 1

protein:increased expression:pancreas

RGD

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659

G

histone deacetylase 1

protein:increased expression:pancreas

RGD

NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:141,853,989...141,881,111

G

inhibitor of nuclear factor kappa B kinase subunit beta

severity
disease_progression

RGD

PMID:22406536 PMID:22056382

RGD:13838740, RGD:13838742

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250

pancreatic mucinous cystadenoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

KRAS proto-oncogene, GTPase

severity

DNA:mutations:cds:

RGD

NCBI chr 4:179,916,255...179,949,613

pancreatic solid pseudopapillary carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin D1

severity

protein:increased expression:pancreas (human)

RGD

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

vipoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interferon, alpha 1

CTD Direct Evidence: therapeutic

NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:103,097,356...103,097,925

G

menin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:213,068,166...213,074,132
Ensembl chr 1:203,639,000...203,644,871

G

somatostatin

CTD Direct Evidence: therapeutic

NCBI chr11:90,461,546...90,462,823
Ensembl chr11:76,956,896...76,958,173

Term paths to the root

Path 1
Term	Annotations
disease	19140
disease of anatomical entity	18453
endocrine system disease	7042
pancreas disease	1256
Pancreatic Neoplasms	424
Pancreatic Benign Neoplasm +	14
islet cell tumor +	30
pancreatic cancer +	421

paths to the root