Lymphatic Vessel Tumors - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Lymphatic Vessel Tumors	go back to main search page
Accession:	DOID:9003008	browse the term
Definition:	Neoplasms composed of lymphoid tissue, a lattice work of reticular tissue the interspaces of which contain lymphocytes. The concept does not refer to neoplasms located in lymphatic vessels.
Synonyms:	exact_synonym:	Lymphatic Vessel Tumor
	narrow_synonym:	malignant lymphatic vessel tumor
	primary_id:	MESH:D018190
	xref:	EFO:1001032

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Rat (41) Mouse (41) Human (554) Chinchilla (40) Bonobo (41) Dog (41) Squirrel (40) Pig (40) Green Monkey (41) Naked Mole-rat (40) All
Genes (41)

colon adenoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

axin 2

protein:increased expression::

RGD

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

calcium voltage-gated channel subunit alpha1 D

protein:increased expression:colon (human)

NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215

G

cyclin D1

severity

RGD

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

severity

RGD

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

choline kinase alpha

protein:increased expression:colonic mucosa (human)

RGD

NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516

G

insulin-like growth factor 2 mRNA binding protein 1

RGD

NCBI chr10:80,908,300...80,951,097
Ensembl chr10:80,908,076...80,951,129

G

Rac family small GTPase 1

RGD

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

retinol binding protein 4

protein:increased expression:blood serum (human)

RGD

NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399

G

tet methylcytosine dioxygenase 2

mRNA:decreased expression:colon (human)

RGD

NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534

cystic lymphangioma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

collagen type XI alpha 2 chain

ClinVar Annotator: match by term: Cystic hygroma

PMID:10677296 PMID:21204229 PMID:22246659 PMID:24033266 PMID:25741868 More...

NCBI chr20:4,786,932...4,816,598
Ensembl chr20:4,786,929...4,815,985

lymphangioleiomyomatosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA synthetase short-chain family member 2

protein:increased expression:lung (human)

RGD

NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675

G

carnitine palmitoyltransferase 1A

protein:increased expression:lung (human)

RGD

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

estrogen receptor 1

RGD

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

glyceraldehyde-3-phosphate dehydrogenase

protein:increased expression:lung (human)

RGD

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

glutaminase

protein:increased expression:lung (human)

RGD

NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900

G

hes family bHLH transcription factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

jagged canonical Notch ligand 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818

G

matrix metallopeptidase 3

treatment

RGD

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

protein:increased expression:serum, plasma

RGD

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

nitric oxide synthase 3

protein:increased expression:lung

RGD

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

nth-like DNA glycosylase 1

ClinVar Annotator: match by term: Lymphangioleiomyomatosis, somatic

PMID:25741868 PMID:28492532

NCBI chr10:13,655,791...13,661,958
Ensembl chr10:13,655,785...13,661,957

G

polycystin 1, transient receptor potential channel interacting

ClinVar Annotator: match by term: Lymphangiomyomatosis

NCBI chr10:13,573,779...13,621,138
Ensembl chr10:13,573,021...13,621,128

G

pyruvate kinase M1/2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

RPTOR independent companion of MTOR, complex 2

protein:increased expression:lung (human)

RGD

NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426

G

solute carrier family 16 member 1

protein:increased expression:lung (human)

RGD

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

serum response factor

RGD

NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733

G

signal transducer and activator of transcription 1

protein:increased serine phosphorylation:lung

RGD

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

protein:increased tyrosine phosphorylation:lung

RGD

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

TSC complex subunit 1

ClinVar Annotator: match by term: Lymphangioleiomyomatosis | ClinVar Annotator: match by term: Lymphangioleiomyomatosis, somatic | ClinVar Annotator: match by term: Lymphangiomyomatosis
CTD Direct Evidence: marker/mechanism

OMIM
ClinVar
CTD

PMID:5279523 PMID:9242607 PMID:9328481 PMID:9536098 PMID:9803264 More...

NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674

G

TSC complex subunit 2

ClinVar Annotator: match by term: Lymphangioleiomyomatosis | ClinVar Annotator: match by term: Lymphangioleiomyomatosis, somatic | ClinVar Annotator: match by term: Lymphangiomyomatosis
CTD Direct Evidence: marker/mechanism
DNA:loss of heterozygosity

ClinVar
CTD
OMIM
RGD

PMID:5279523 PMID:8824881 PMID:9076719 PMID:9285776 PMID:9302281 More...

RGD:1580521, RGD:11568662

NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951

G

vascular endothelial growth factor D

CTD Direct Evidence: marker/mechanism

NCBI chr X:30,073,122...30,108,413
Ensembl chr X:30,074,163...30,108,295

lymphangioma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Lymphangioma

PMID:12068308 PMID:12198537 PMID:12447372 PMID:12460918 PMID:12460919 More...

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

Fms related receptor tyrosine kinase 4

protein:increased expression:;lymphatic endothelial cell:

RGD

NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770

G

kinase insert domain receptor

protein:increased expression:;lymphatic endothelial cell:

RGD

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

ClinVar Annotator: match by term: Cavernous lymphangioma

PMID:15016963 PMID:15254419 PMID:15520168 PMID:15647370 PMID:15805248 More...

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

Nuchal Bleb, Familial

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CF transmembrane conductance regulator

ClinVar Annotator: match by term: Fetal cystic hygroma

PMID:1695717 PMID:7683952 PMID:7691345 PMID:9239681 PMID:9725922 More...

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

leucine zipper like post translational regulator 1

ClinVar Annotator: match by term: Fetal cystic hygroma

PMID:25741868 PMID:25795793 PMID:28492532 PMID:30368668 PMID:30442762 More...

NCBI chr11:83,487,717...83,503,896
Ensembl chr11:83,487,717...83,503,633

G

SOS Ras/Rac guanine nucleotide exchange factor 1

ClinVar Annotator: match by term: Nuchal bleb, familial

PMID:17143285 PMID:17586837 PMID:20186801 PMID:21387466 PMID:22494877 More...

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

sigmoid neoplasm

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

APC regulator of WNT signaling pathway

ClinVar Annotator: match by term: Sigmoid colon cancer

PMID:25741868 PMID:28492532

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

mutS homolog 2

ClinVar Annotator: match by term: Sigmoid colon cancer

PMID:10495924 PMID:12658575 PMID:15849733 PMID:17312306 PMID:18566915 More...

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

mutS homolog 6

ClinVar Annotator: match by term: Sigmoid colon cancer

PMID:9354786 PMID:12376507 PMID:18809606 PMID:19924528 PMID:20176959 More...

NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956

Term paths to the root

Path 1
Term	Annotations
disease	19099
disease of cellular proliferation	7914
Neoplasms by Histologic Type	5403
Lymphatic Vessel Tumors	41
Lymphangiomyoma +	21
lymphangioma +	20
lymphangiosarcoma +	0

paths to the root