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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Nematode Infections
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Accession:DOID:9002992 term browser browse the term
Definition:Infections by nematodes, general or unspecified.
Synonyms:exact_synonym: Nematoda infectious disease;   Nematode Infection
 primary_id: MESH:D009349
 xref: EFO:0007391


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Nematode Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP protein:increased expression:liver (rat) RGD PMID:12621079 RGD:2306675 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 severity ISO RGD PMID:27697499 RGD:40400689 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891 		JBrowse link
G Il33 interleukin 33 ISO associated with Nippostrongylus brasiliensis infection; mRNA:increased expression:lung RGD PMID:22331917 RGD:40400742 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901 		JBrowse link
G Il4 interleukin 4 IEP mRNA:increased expression:spleen RGD PMID:17570971 RGD:2317296 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Muc13 mucin 13, cell surface associated ISO protein:increased expression:cecum, glycocalyx RGD PMID:21155842 RGD:7364766 NCBI chr11:80,462,350...80,489,773
Ensembl chr11:80,465,737...80,485,474 		JBrowse link
G Muc17 mucin 17, cell surface associated IEP mRNA:increased expression:intestine RGD PMID:16689826 RGD:2303607 NCBI chr12:25,139,076...25,175,249 JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming IEP
ISO 		mRNA:increased expression:intestine RGD PMID:16689826 PMID:20138044 RGD:2303607, RGD:7349349 NCBI chr 1:206,225,775...206,261,280
Ensembl chr 1:206,229,035...206,261,280 		JBrowse link
G Muc4 mucin 4, cell surface associated IEP
ISO 		mRNA:increased expression:intestine
protein:increased expression:cecum, glycocalyx 		RGD PMID:16689826 PMID:21155842 RGD:2303607, RGD:7364766 NCBI chr11:81,513,321...81,575,200 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming resistance ISO
IEP 		mRNA:increased expression:cecum RGD PMID:20138044 PMID:22269441 RGD:7349349, RGD:7364747 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 susceptibility ISO RGD PMID:11850627 RGD:737789 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IEP mRNA:increased expression:liver (rat) RGD PMID:20695884 RGD:5130965 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816 		JBrowse link
angiostrongyliasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1rl1 interleukin 1 receptor-like 1 treatment ISO mRNA:increased expression:brain: RGD PMID:24657070 PMID:23148283 RGD:11561855, RGD:40400713 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891 		JBrowse link
G Il33 interleukin 33 ISO protein:increased expression:brain: RGD PMID:23148283 PMID:24076431 RGD:40400713, RGD:40400715 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901 		JBrowse link
G Il5 interleukin 5 ISO RGD PMID:8361777 RGD:11354948 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Mag myelin-associated glycoprotein disease_progression ISO RGD PMID:20399564 RGD:27226693 NCBI chr 1:95,275,728...95,291,133
Ensembl chr 1:95,275,635...95,291,060 		JBrowse link
G Mbp myelin basic protein disease_progression ISO RGD PMID:20399564 RGD:27226693 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174 		JBrowse link
G Mobp myelin-associated oligodendrocyte basic protein disease_progression ISO RGD PMID:20399564 RGD:27226693 NCBI chr 8:128,747,117...128,777,238
Ensembl chr 8:128,747,232...128,777,936 		JBrowse link
filariasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1rl1 interleukin 1 receptor-like 1 ISO RGD PMID:27592711 RGD:40400889 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891 		JBrowse link
G Prg2 proteoglycan 2, pro eosinophil major basic protein ISO RGD PMID:24626328 RGD:40903014 NCBI chr 3:90,469,192...90,472,759
Ensembl chr 3:90,469,176...90,472,752 		JBrowse link
Hookworm Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1rl1 interleukin 1 receptor-like 1 ISO RGD PMID:22329990 RGD:39938827 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891 		JBrowse link
G Il33 interleukin 33 ISO mRNA,protein:increased expression:Bronchoalveolar lavage, epithelium, macrophage RGD PMID:22329990 RGD:39938827 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901 		JBrowse link
G Tff2 trefoil factor 2 ISO RGD PMID:22329990 RGD:39938827 NCBI chr20:9,217,110...9,220,979
Ensembl chr20:9,217,121...9,220,979 		JBrowse link
Ocular Onchocerciasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1r1 interleukin 1 receptor type 1 ISO RGD PMID:19168746 RGD:8662882 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579 		JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:11884755 RGD:7794682 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
onchocerciasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 severity ISO protein:increased expression:serum RGD PMID:22805723 RGD:8549600 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G RT1-Ba RT1 class II, locus Ba susceptibility ISO DNA:polymorphisms: :HLA-DQA1*0401, HLA-DQA1*0102,HLA-DQA1*0103; RGD PMID:22117902 RGD:8547660 NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,576,843...4,581,653 		JBrowse link
G RT1-Ha RT1 class II, locus Ha ISO RGD PMID:8854084 RGD:6480649 NCBI chr20:4,762,425...4,772,439
Ensembl chr20:4,763,033...4,772,141 		JBrowse link
Strongylida Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase ISO RGD PMID:23630966 RGD:32716404 NCBI chr 4:157,446,120...157,455,958
Ensembl chr 4:157,444,697...157,456,356 		JBrowse link
G Il3 interleukin 3 ISO RGD PMID:20500666 RGD:5686890 NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,906,460...38,908,810 		JBrowse link
G Il33 interleukin 33 ISO mRNA:increased expression:lung RGD PMID:22331917 RGD:40400742 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901 		JBrowse link
G Plau plasminogen activator, urokinase IMP RGD PMID:18022622 RGD:6484141 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030 		JBrowse link
strongyloidiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 treatment ISO RGD PMID:16129701 RGD:8655932 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il5 interleukin 5 severity ISO RGD PMID:9824515 RGD:11354934 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
toxascariasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tslp thymic stromal lymphopoietin ISO mRNA:increased expression:multiple (mouse) RGD PMID:24327787 RGD:38596353 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,720,257...24,728,420 		JBrowse link
Toxocara Canis Infection (Canine Roundworms) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl11 C-C motif chemokine ligand 11 ISO protein:increased expression:plasma, respiratory system fluid/secretion RGD PMID:16168564 RGD:7248410 NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,525,862...67,530,575 		JBrowse link
toxocariasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 treatment ISO RGD PMID:26732352 RGD:11534298 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Olig2 oligodendrocyte transcription factor 2 ISO RGD PMID:25773181 RGD:40902825 NCBI chr11:43,961,585...43,964,961
Ensembl chr11:43,958,940...43,968,634 		JBrowse link
trichinosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO RGD PMID:23465441 RGD:11049476 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Lta lymphotoxin alpha ISO RGD PMID:19564380 RGD:8548805 NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,623,527...3,625,533 		JBrowse link
G Slc17a8 solute carrier family 17 member 8 IEP protein:increased expression:dorsal horn of spinal cord, dorsal root ganglion RGD PMID:22160634 RGD:9999169 NCBI chr 7:25,881,557...25,936,837
Ensembl chr 7:25,881,557...25,935,410 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO protein:decreased expression:jejunum (mouse) RGD PMID:16336502 RGD:38676482 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056 		JBrowse link
G Tnf tumor necrosis factor ISO RGD PMID:19564380 RGD:8548805 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tslp thymic stromal lymphopoietin disease_progression ISO RGD PMID:23024277 RGD:38596337 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,720,257...24,728,420 		JBrowse link
trichostrongyloidiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp1 forkhead box P1 IEP mRNA:increased expression:duodenum (rat) RGD PMID:21698235 RGD:11561920 NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:133,122,055...133,500,272 		JBrowse link
trichuriasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:20864659 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Mpo myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20864659 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Tslp thymic stromal lymphopoietin susceptibility ISO RGD PMID:19273626 RGD:38549593 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,720,257...24,728,420 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14566
    disease by infectious agent 1953
      parasitic infectious disease 282
        parasitic helminthiasis infectious disease 83
          Nematode Infections 38
            Adenophorea Infections + 8
            Larva Migrans + 3
            Secernentea Infections + 22
            capillariasis 0
            thelaziasis 0
paths to the root