Colonic Neoplasms - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Colonic Neoplasms	go back to main search page
Accession:	DOID:9002928	browse the term
Definition:	Tumors of the COLON.
Synonyms:	exact_synonym:	colon neoplasm; colon neoplasms; colonic neoplasm; colonic tumor; neoplasm of colon
	primary_id:	MESH:D003110
	xref:	EFO:0004288; EFO:1000187

show annotations for term's descendants Sort by:
Rat (412) Mouse (516) Human (4392) Chinchilla (360) Bonobo (381) Dog (396) Squirrel (366) Pig (388) Green Monkey (376) Naked Mole-rat (355) All
Genes (409) Strains (3)

Colonic Neoplasms

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

CTD Direct Evidence: marker/mechanism

NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786

G

actin alpha 2, smooth muscle

CTD Direct Evidence: marker/mechanism

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554

G

actin gamma 2, smooth muscle

CTD Direct Evidence: marker/mechanism

NCBI chr 4:117,579,513...117,604,379
Ensembl chr 4:116,021,832...116,046,465

G

aldehyde dehydrogenase 1 family, member B1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:64,859,000...64,864,008
Ensembl chr 5:60,063,225...60,068,378

G

arachidonate 12-lipoxygenase, 12R type

CTD Direct Evidence: marker/mechanism

NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938

G

arachidonate 5-lipoxygenase

CTD Direct Evidence: marker/mechanism

PMID:14569062 PMID:18927292 PMID:30258081

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:149,531,515...149,578,743

G

APC regulator of WNT signaling pathway

ClinVar Annotator: match by term: Colonic neoplasm
CTD Direct Evidence: marker/mechanism

ClinVar
CTD
RGD

PMID:7846077 PMID:7959691 PMID:8608549 PMID:10383901 PMID:12034317 More...

NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696

G

APC, WNT signaling pathway regulator; polyposis in the rat colon

RGD

G

achaete-scute family bHLH transcription factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:198,148,999...198,151,406

G

ATM serine/threonine kinase

ClinVar Annotator: match by term: Colonic neoplasm

PMID:23807571 PMID:25614872 PMID:25741868 PMID:28492532 PMID:30482293 More...

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437

G

ATPase copper transporting alpha

CTD Direct Evidence: marker/mechanism

NCBI chr X:75,159,635...75,267,094
Ensembl chr X:71,094,202...71,198,354

G

axin 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:94,393,379...94,426,579
Ensembl chr10:93,899,245...93,926,231

G

BCL2-antagonist/killer 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264

G

BRCA1 associated deubiquitinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:6,453,126...6,461,952
Ensembl chr16:6,446,709...6,455,535

G

BCL2 associated X, apoptosis regulator

CTD Direct Evidence: marker/mechanism

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

mRNA:increased expression:colon
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:10223192 PMID:17404573 PMID:19147571 PMID:17404573

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

beclin 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742

G

baculoviral IAP repeat-containing 5

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:16224667 PMID:19147571

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380

G

bromodomain containing 4

CTD Direct Evidence: marker/mechanism

NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,216,446...11,295,539

G

similar to human chromosome 11 open reading frame 65

ClinVar Annotator: match by term: Colonic neoplasm

PMID:23807571 PMID:25614872 PMID:25741868 PMID:28492532 PMID:30482293 More...

NCBI chr 8:62,692,123...62,720,951
Ensembl chr 8:53,796,366...53,824,748

G

calcium voltage-gated channel auxiliary subunit alpha2delta 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:19,902,324...20,330,287
Ensembl chr 4:18,951,002...19,374,969

G

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

RGD

NCBI chr 6:31,012,091...31,035,098
Ensembl chr 6:25,292,133...25,319,861

G

carbonic anhydrase 4

CTD Direct Evidence: marker/mechanism

NCBI chr10:70,325,102...70,333,916
Ensembl chr10:69,827,945...69,836,501

G

caspase 3

treatment

RGD

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

carbonyl reductase 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

C-C motif chemokine ligand 2

treatment

human gene in mouse model

RGD

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

CTD Direct Evidence: marker/mechanism

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938

G

cyclin D1

CTD Direct Evidence: marker/mechanism

PMID:18283038 PMID:19147571 PMID:21081470 PMID:21188121

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

CTD Direct Evidence: marker/mechanism

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:159,962,363...159,989,495

G

cyclin E1

mRNA, protein:increased expression:colon

RGD

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101

G

cyclin H

CTD Direct Evidence: marker/mechanism

NCBI chr 2:17,570,449...17,591,078
Ensembl chr 2:15,834,833...15,855,819

G

C-C motif chemokine receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:132,433,711...132,439,266

G

C-C motif chemokine receptor 5

CTD Direct Evidence: marker/mechanism

NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:123,752,325...123,759,260

G

CD40 ligand

RGD

NCBI chr X:140,164,341...140,176,057
Ensembl chr X:135,126,969...135,138,306

G

cyclin-dependent kinase inhibitor 1A

CTD Direct Evidence: marker/mechanism

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

mRNA, Protein:decreased expression:colon

RGD

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149

G

caudal type homeo box 2

CTD Direct Evidence: marker/mechanism

NCBI chr12:12,762,769...12,769,246
Ensembl chr12:7,726,798...7,733,142

G

checkpoint kinase 2

ClinVar Annotator: match by term: Colonic Neoplasms

PMID:16794575 PMID:21244692 PMID:22419737 PMID:25741868 PMID:26467025 More...

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286

G

creatine kinase, M-type

CTD Direct Evidence: marker/mechanism

NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:79,061,456...79,071,720

G

collagen type XVIII alpha 1 chain

severity

RGD

NCBI chr20:11,473,645...11,582,111
Ensembl chr20:11,474,104...11,582,593

G

ceruloplasmin

CTD Direct Evidence: marker/mechanism

NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:102,439,624...102,498,075

G

crystallin, alpha B

CTD Direct Evidence: marker/mechanism

NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:51,093,441...51,099,157

G

catenin beta 1

CTD Direct Evidence: marker/mechanism

PMID:9515794 PMID:12628520 PMID:12800193 PMID:14507667 PMID:15459021 More...

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 10

CTD Direct Evidence: marker/mechanism

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975

G

cytochrome P450, family 26, subfamily a, polypeptide 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:235,471,298...235,475,204

G

defensin alpha 5

CTD Direct Evidence: marker/mechanism

NCBI chr16:77,044,994...77,047,318
Ensembl chr16:70,342,530...70,344,836

G

defensin alpha-like 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:77,073,954...77,074,943
Ensembl chr16:70,371,518...70,372,353

G

deleted in malignant brain tumors 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:195,047,702...195,126,704
Ensembl chr 1:185,617,294...185,696,478

G

DNA methyltransferase 1

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:19723570 PMID:19723570

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659

G

dihydropyrimidine dehydrogenase

CTD Direct Evidence: marker/mechanism

NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:206,609,122...207,474,982

G

epidermal growth factor receptor

CTD Direct Evidence: marker/mechanism

PMID:14569062 PMID:25200834

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 3, subunit I

CTD Direct Evidence: marker/mechanism

NCBI chr 5:141,935,135...141,942,589
Ensembl chr 5:141,935,044...141,942,676

G

eomesodermin

CTD Direct Evidence: marker/mechanism

NCBI chr 8:127,059,215...127,067,070
Ensembl chr 8:118,181,777...118,188,316

G

epithelial cell adhesion molecule

ClinVar Annotator: match by term: Colonic neoplasm

NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:6,878,237...6,896,127

G

erb-b2 receptor tyrosine kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078

G

coagulation factor V

protein:increased expression:serum
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:25200834 PMID:25200834

NCBI chr13:79,046,657...79,116,247
Ensembl chr13:76,513,255...76,582,317

G

Fas cell surface death receptor

resistance

protein:increased expression

RGD

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

fructose-bisphosphatase 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:2,212,941...2,235,749
Ensembl chr17:2,208,031...2,230,071

G

folate receptor alpha

CTD Direct Evidence: marker/mechanism

PMID:15705887 PMID:18926688

NCBI chr 1:165,631,462...165,650,430
Ensembl chr 1:156,219,460...156,230,667

G

Fos proto-oncogene, AP-1 transcription factor subunit

RGD

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

frizzled class receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:88,061,988...88,063,898
Ensembl chr10:87,561,326...87,565,334

G

growth associated protein 43

CTD Direct Evidence: marker/mechanism

NCBI chr11:71,882,131...71,975,799
Ensembl chr11:58,376,371...58,470,045

G

gastrin

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,264,832...85,267,496

G

glucagon

CTD Direct Evidence: marker/mechanism

NCBI chr 3:67,522,489...67,531,533
Ensembl chr 3:47,113,914...47,122,929

G

glutamate ionotropic receptor kainate type subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr20:53,717,564...54,415,283
Ensembl chr20:52,133,851...52,838,375

G

glycogen synthase kinase 3 beta

treatment
disease_progression

protein:increased expression:nucleus

RGD

PMID:23729362 PMID:23389968

RGD:13210765, RGD:13210769

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione S-transferase, mu 5-like

CTD Direct Evidence: marker/mechanism

NCBI chr 2:198,231,285...198,238,122
Ensembl chr 2:195,544,426...195,628,961

G

guanylate cyclase 1 soluble subunit alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:169,716,684...169,780,360
Ensembl chr 2:167,418,640...167,481,671

G

histone deacetylase 2

mRNA:increased expression:colon:
DNA:mutations:colon:

RGD

PMID:23724067 PMID:16642021

RGD:9590193, RGD:9590331

NCBI chr20:42,101,815...42,126,486
Ensembl chr20:40,548,250...40,571,609

G

hes family bHLH transcription factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:84,210,632...84,213,045
Ensembl chr11:70,705,764...70,708,192

G

hypoxia inducible factor 1 subunit alpha

severity

RGD

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

CTD Direct Evidence: marker/mechanism

PMID:15059925 PMID:27816970

NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:185,875,616...185,902,130

G

heat shock protein family A (Hsp70) member 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family B (small) member 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743

G

intercellular adhesion molecule 1

CTD Direct Evidence: marker/mechanism

PMID:7902311 PMID:16497620

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 3

CTD Direct Evidence: marker/mechanism

NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:148,372,762...148,374,349

G

interferon gamma

CTD Direct Evidence: therapeutic

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:197,814,410...197,823,018

G

insulin-like growth factor binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:82,047,415...82,052,482

G

interleukin 1 beta

CTD Direct Evidence: marker/mechanism

PMID:15059925 PMID:18987561 PMID:19028472

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

CTD Direct Evidence: marker/mechanism

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445

G

integrin subunit alpha 7

CTD Direct Evidence: marker/mechanism

NCBI chr 7:1,944,447...1,973,347
Ensembl chr 7:1,359,940...1,388,450

G

inter-alpha-trypsin inhibitor heavy chain 4

CTD Direct Evidence: marker/mechanism
protein:increased expression:serum

CTD
RGD

PMID:25200834 PMID:25200834

NCBI chr16:6,086,985...6,102,162
Ensembl chr16:6,080,539...6,095,708

G

Janus kinase 3

treatment

RGD

NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,386,405...18,398,536

G

Jun proto-oncogene, AP-1 transcription factor subunit

CTD Direct Evidence: marker/mechanism

PMID:12628520 PMID:18283038

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel subfamily H member 2

CTD Direct Evidence: marker/mechanism

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008

G

lysine demethylase 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 5:154,066,436...154,121,913
Ensembl chr 5:148,782,976...148,838,319

G

lysine demethylase 5B

CTD Direct Evidence: marker/mechanism

NCBI chr13:48,554,367...48,625,721
Ensembl chr13:46,002,542...46,073,872

G

kinase insert domain receptor

associated with Colitis;mRNA, protein:increased expression:colon

RGD

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018

G

KRAS proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism

PMID:10813127 PMID:12800193 PMID:12839936 PMID:17192441 PMID:18372904 More...

NCBI chr 4:179,916,255...179,949,613

G

lymphoid enhancer binding factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:219,666,592...219,779,794

G

leptin

CTD Direct Evidence: marker/mechanism

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262

G

leucine rich repeat containing G protein coupled receptor 5

CTD Direct Evidence: marker/mechanism

NCBI chr 7:51,087,059...51,221,882
Ensembl chr 7:51,088,239...51,222,446

G

lipoprotein lipase

CTD Direct Evidence: marker/mechanism

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249

G

leucine-rich alpha-2-glycoprotein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:1,034,691...1,036,937
Ensembl chr 9:947,516...949,813

G

lactotransferrin

CTD Direct Evidence: therapeutic

NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:110,999,948...111,022,795

G

macrophage immunometabolism regulator

CTD Direct Evidence: marker/mechanism

NCBI chr 9:105,868,072...105,888,128
Ensembl chr 9:98,420,376...98,441,733

G

monoamine oxidase B

CTD Direct Evidence: marker/mechanism

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:5,907,266...6,011,003

G

mitogen-activated protein kinase kinase 6

CTD Direct Evidence: therapeutic

NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,373,204...95,488,293

G

mitogen-activated protein kinase 8

treatment

RGD

PMID:17591974 PMID:18460448

RGD:13217412, RGD:13217414

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

G

minichromosome maintenance complex component 2

CTD Direct Evidence: therapeutic

NCBI chr 4:122,903,679...122,918,205
Ensembl chr 4:121,346,434...121,360,847

G

MDS1 and EVI1 complex locus

CTD Direct Evidence: marker/mechanism

NCBI chr 2:114,837,815...115,393,052
Ensembl chr 2:112,909,321...113,464,590

G

menin 1

severity

RGD

NCBI chr 1:213,068,166...213,074,132
Ensembl chr 1:203,639,000...203,644,871

G

meprin A subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 9:24,971,901...25,001,414
Ensembl chr 9:17,474,619...17,504,147

G

microRNA 223

CTD Direct Evidence: marker/mechanism

NCBI chr X:65,151,383...65,151,492
Ensembl chr X:61,141,887...61,141,996

G

microRNA 31

associated with inflammatory bowel disease; RNA:increased expression:colorectal mucosa (human)

NCBI chr 5:108,714,849...108,714,954

G

microRNA 98

CTD Direct Evidence: marker/mechanism

NCBI chr X:24,460,648...24,460,755
Ensembl chr X:20,981,235...20,981,342

G

marker of proliferation Ki-67

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:19028472 PMID:22070864

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762

G

mutL homolog 1

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Colonic Neoplasms | ClinVar Annotator: match by term: Colonic neoplasm

PMID:7728749 PMID:8574961 PMID:8797773 PMID:9490293 PMID:11524701 More...

NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:111,196,468...111,233,617

G

matrix metallopeptidase 12

CTD Direct Evidence: marker/mechanism

NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 7

CTD Direct Evidence: marker/mechanism

NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902

G

matrix metallopeptidase 9

disease_progression

mRNA:increased expression:colon
CTD Direct Evidence: marker/mechanism
protein:increased expression, increased activity:large intestine mucosa

CTD
RGD

PMID:15725655 PMID:20428773 PMID:21268133

RGD:2325778, RGD:5135051

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

MRE11 homolog, double strand break repair nuclease

DNA:deletions:intron:IVS4_delT (human)
ClinVar Annotator: match by term: Colonic neoplasm

PMID:23080121 PMID:23912341 PMID:25452441 PMID:25741868 PMID:26556299 More...

NCBI chr 8:19,900,211...19,961,906
Ensembl chr 8:11,632,354...11,678,279

G

methylenetetrahydrofolate reductase

CTD Direct Evidence: marker/mechanism

NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797

G

mechanistic target of rapamycin kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

mutY DNA glycosylase

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Colonic neoplasm

PMID:16890597 PMID:19394335 PMID:19732775 PMID:20618354 PMID:20628285 More...

NCBI chr 5:135,510,666...135,522,777
Ensembl chr 5:130,274,122...130,286,146

G

MYC proto-oncogene, bHLH transcription factor

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12189186 PMID:15059925 PMID:18283038 PMID:21081470 PMID:22641368

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

G

NDRG family member 2

CTD Direct Evidence: marker/mechanism

NCBI chr15:27,074,481...27,087,376
Ensembl chr15:24,600,982...24,609,626

G

nuclear factor kappa B subunit 1

CTD Direct Evidence: marker/mechanism

PMID:19028472 PMID:20715105

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

nucleotide-binding oligomerization domain containing 2

DNA:insertion:Cds: 3020_3021insC (human)

RGD

NCBI chr19:34,555,832...34,596,281
Ensembl chr19:18,382,439...18,417,177

G

nitric oxide synthase 2

CTD Direct Evidence: marker/mechanism

PMID:16105666 PMID:21081470

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531

G

NADPH oxidase 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:101,572,338...101,625,571
Ensembl chr X:97,279,056...97,302,236

G

NADPH oxidase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406

G

ornithine decarboxylase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:40,329,964...40,336,440

G

oxytocin/neurophysin I prepropeptide

CTD Direct Evidence: therapeutic

NCBI chr 3:138,235,754...138,236,594
Ensembl chr 3:117,782,650...117,783,490

G

poly (ADP-ribose) polymerase family, member 4

exacerbates

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16204055 PMID:16204055

NCBI chr15:34,806,203...34,908,492
Ensembl chr15:30,686,613...30,828,810

G

proliferating cell nuclear antigen

CTD Direct Evidence: marker/mechanism

PMID:19028472 PMID:19723570

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995

G

Purkinje cell protein 4

CTD Direct Evidence: marker/mechanism

NCBI chr11:49,229,185...49,331,186
Ensembl chr11:35,800,713...35,861,725

G

programmed cell death 1

treatment

RGD

NCBI chr 9:101,866,124...101,879,278
Ensembl chr 9:94,418,791...94,431,937

G

platelet derived growth factor receptor beta

RGD

NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843

G

platelet and endothelial cell adhesion molecule 1

RGD

NCBI chr10:92,090,263...92,152,002
Ensembl chr10:91,590,521...91,652,116

G

phosphoinositide-3-kinase regulatory subunit 1

RGD

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631

G

phosphoinositide-3-kinase regulatory subunit 2

RGD

NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,665,457...18,674,065

G

plasminogen activator, urokinase

treatment

protein:increased expression:colon, mucosa (human)
human tumor cell line in mouse model

RGD

PMID:3884145 PMID:19214512

RGD:7241262, RGD:7241805

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775

G

phospholipase C beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:122,060,031...122,772,869

G

PMS1 homolog 2, mismatch repair system component

RGD

NCBI chr12:15,790,478...15,814,790
Ensembl chr12:10,676,764...10,701,066

G

DNA polymerase beta

CTD Direct Evidence: marker/mechanism

NCBI chr16:76,081,903...76,105,174
Ensembl chr16:69,379,400...69,404,812

G

peroxisome proliferator-activated receptor gamma

CTD Direct Evidence: therapeutic

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

perforin 1

associated with Colitis

RGD

NCBI chr20:29,789,040...29,794,550
Ensembl chr20:29,246,202...29,251,701

G

parkin RBR E3 ubiquitin protein ligase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555

G

prominin 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:71,202,303...71,307,008
Ensembl chr14:66,990,160...67,094,527

G

prostaglandin E receptor 3

severity

RGD

NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:246,606,183...246,684,434

G

prostaglandin-endoperoxide synthase 2

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12189188 PMID:17667525 PMID:21081470 PMID:21268133

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase 4A3

CTD Direct Evidence: therapeutic

NCBI chr 7:105,650,640...105,660,921
Ensembl chr 7:105,628,029...105,660,919

G

defensin rat NP-3 precursor

CTD Direct Evidence: marker/mechanism

NCBI chr16:77,246,811...77,248,977
Ensembl chr16:70,513,888...70,546,522

G

REST corepressor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:135,890,851...135,967,367
Ensembl chr 6:130,069,392...130,146,153

G

reversion-inducing-cysteine-rich protein with kazal motifs

CTD Direct Evidence: marker/mechanism

NCBI chr 5:62,898,717...62,965,274
Ensembl chr 5:58,102,981...58,169,502

G

RELA proto-oncogene, NF-kB subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

replication factor C subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:43,319,768...43,395,028
Ensembl chr14:42,966,324...43,041,370

G

ras homolog family member J

CTD Direct Evidence: marker/mechanism

NCBI chr 6:99,771,104...99,853,366
Ensembl chr 6:94,035,483...94,118,275

G

ring finger protein 34

CTD Direct Evidence: therapeutic

NCBI chr12:39,364,461...39,385,391
Ensembl chr12:33,703,673...33,724,586

G

RUNX family transcription factor 3

DNA:hypermethylation:promoter

RGD

NCBI chr 5:152,644,270...152,702,835
Ensembl chr 5:147,360,994...147,419,156

G

S100 calcium-binding protein A4

CTD Direct Evidence: marker/mechanism

NCBI chr 2:178,388,529...178,390,838
Ensembl chr 2:176,091,804...176,093,254

G

S100 calcium binding protein A9

CTD Direct Evidence: marker/mechanism

NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:176,190,361...176,193,230

G

serpin family B member 5

CTD Direct Evidence: marker/mechanism

NCBI chr13:23,500,203...23,520,401
Ensembl chr13:22,985,557...23,005,756

G

SERTA domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:91,903,297...91,906,565
Ensembl chr 1:82,775,252...82,779,091

G

SH3 domain-containing kinase-binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:38,686,530...39,031,658
Ensembl chr X:34,877,866...35,222,747

G

solute carrier family 16 member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:192,124,289...192,144,611

G

solute carrier family 19 member 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:11,583,928...11,601,959
Ensembl chr20:11,584,411...11,601,972

G

solute carrier family 22 member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 2 member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 5 member 8

CTD Direct Evidence: marker/mechanism

PMID:15090606 PMID:16670197

NCBI chr 7:25,160,280...25,201,185
Ensembl chr 7:23,272,427...23,314,642

G

solute carrier organic anion transporter family member 1B2

CTD Direct Evidence: marker/mechanism

PMID:22326869 PMID:25625007

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:174,551,480...174,619,981

G

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

secreted protein acidic and cysteine rich

CTD Direct Evidence: marker/mechanism

NCBI chr10:40,017,065...40,038,816
Ensembl chr10:39,516,406...39,538,396

G

SRC proto-oncogene, non-receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

sulfotransferase family 1A member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:181,272,023...181,275,562

G

transgelin

CTD Direct Evidence: marker/mechanism

NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:46,222,472...46,230,668

G

transcription factor 19

CTD Direct Evidence: marker/mechanism

NCBI chr20:3,223,464...3,227,569
Ensembl chr20:3,218,693...3,223,271

G

transcription factor 7 like 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:254,786,091...254,978,967

G

transforming growth factor, beta receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228

G

tumor necrosis factor

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:12842827 PMID:19028472

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 10b

CTD Direct Evidence: marker/mechanism

NCBI chr15:51,249,883...51,278,091
Ensembl chr15:44,840,386...44,867,467

G

TNF receptor superfamily member 9

CTD Direct Evidence: marker/mechanism

NCBI chr 5:166,664,494...166,690,834
Ensembl chr 5:161,381,662...161,408,000

G

TNF superfamily member 10

CTD Direct Evidence: therapeutic

NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135

G

tumor protein p53

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Colonic neoplasm

PMID:12826609 PMID:17075118 PMID:17192441 PMID:20978130 PMID:24549055 More...

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p53 binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:128,620,320...128,724,716
Ensembl chr 3:108,169,980...108,269,822

G

tropomyosin 3

CTD Direct Evidence: marker/mechanism

NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:175,517,226...175,545,013

G

tRNA methyltransferase 11 homolog

CTD Direct Evidence: marker/mechanism

NCBI chr 1:28,873,361...28,928,679
Ensembl chr 1:27,054,420...27,201,610

G

thymidine phosphorylase

CTD Direct Evidence: marker/mechanism

NCBI chr 7:122,318,396...122,323,716
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874

G

thymidylate synthetase

CTD Direct Evidence: marker/mechanism

PMID:15355913 PMID:16284371 PMID:16609021 PMID:18192902 PMID:18652704 More...

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536

G

ubiquitin-like with PHD and ring finger domains 1

treatment

RGD

NCBI chr 9:1,220,162...1,241,792
Ensembl chr 9:1,134,909...1,154,631

G

uridine monophosphate synthetase

CTD Direct Evidence: marker/mechanism

NCBI chr11:80,311,269...80,321,678
Ensembl chr11:66,806,045...66,821,903

G

ubiquitin specific peptidase 39

CTD Direct Evidence: marker/mechanism

NCBI chr 4:105,932,140...105,964,551
Ensembl chr 4:104,373,955...104,406,359

G

vascular endothelial growth factor A

associated with Colitis
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:18987561 PMID:21098094

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

G

WT1 transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:91,567,001...91,613,643

G

XIAP associated factor 1

CTD Direct Evidence: marker/mechanism

PMID:15843754 PMID:17087954

NCBI chr10:57,415,935...57,428,348
Ensembl chr10:56,917,121...56,929,770

G

xanthine dehydrogenase

RGD

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268

G

Y box binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:138,167,444...138,188,155
Ensembl chr 5:132,882,145...132,898,862

ascending colon cancer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

APC regulator of WNT signaling pathway

ClinVar Annotator: match by term: Malignant tumor of ascending colon

PMID:25741868 PMID:28492532 PMID:30093976

NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696

G

mutS homolog 2

ClinVar Annotator: match by term: Malignant tumor of ascending colon

PMID:9311737 PMID:9718327 PMID:11208710 PMID:11524701 PMID:11601928 More...

NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938

G

DNA polymerase epsilon, catalytic subunit

susceptibility
onset

DNA:missense mutation:CDS, exon 9:p.P286R (human)
DNA:mutations:multiple (human, non-Asian)
DNA:mutations:multiple (human)

RGD

PMID:27612425 PMID:33125191 PMID:28404093

RGD:151347640, RGD:151347651, RGD:151347649

NCBI chr12:52,005,155...52,053,761
Ensembl chr12:46,345,420...46,393,939

G

ring finger protein 43

exacerbates

DNA:nonsense mutation, frameshift mutations:CDS:multiple (human)

RGD

NCBI chr10:72,958,744...73,034,540
Ensembl chr10:72,464,348...72,536,977

Colitis-Associated Neoplasms

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

baculoviral IAP repeat-containing 3

ameliorates
disease_progression

mRNA:increased expression:colonic mucosa (human)

RGD

PMID:26037070 PMID:23388545

RGD:11537970, RGD:153323294

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802

G

cytochrome P450, family 24, subfamily a, polypeptide 1

treatment

RGD

NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:159,275,947...159,290,383

G

mitogen activated protein kinase 14

ameliorates
exacerbates

RGD

PMID:30541887 PMID:29907597 PMID:24684847

RGD:151665503, RGD:151665504, RGD:151665506

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589

G

microRNA 31

exacerbates

RGD

NCBI chr 5:108,714,849...108,714,954

G

MYD88, innate immune signal transduction adaptor

ameliorates
exacerbates

RGD

PMID:26712311 PMID:30650348 PMID:29960049 PMID:21519141

RGD:150520168, RGD:150521528, RGD:150530281, RGD:150530283

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415

colon adenocarcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

abhydrolase domain containing 5, lysophosphatidic acid acyltransferase

disease_progression

human cells in mouse model
mRNA:decreased expression:colon (human)

RGD

PMID:30842415 PMID:30842415

RGD:153002829, RGD:153002829

NCBI chr 8:122,000,241...122,026,447
Ensembl chr 8:122,000,389...122,026,447

G

annexin A7

protein:decreased expression:colon

RGD

NCBI chr15:3,869,180...3,897,827
Ensembl chr15:3,821,845...3,849,385

G

APC regulator of WNT signaling pathway

associated with Adenomatous Polyposis Coli;DNA:point mutation:CDS:p.K1137X (3409A>T) (rat)
ClinVar Annotator: match by term: Colon adenocarcinoma

PMID:24033266 PMID:24728327 PMID:25741868 PMID:27978560 PMID:28492532 More...

NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696

G

APC, WNT signaling pathway regulator; polyposis in the rat colon

associated with Adenomatous Polyposis Coli

RGD

G

AT-rich interaction domain 1A

disease_progression

protein:decreased expression:colorectum (human)

NCBI chr 5:151,192,014...151,269,291
Ensembl chr 5:145,908,181...145,985,564

G

BCL2 associated X, apoptosis regulator

susceptibility

DNA:frameshift mutation: ;

RGD

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

treatment

human cells in mouse model

RGD

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bruton tyrosine kinase

mRNA:decreased expression:colon (human)

NCBI chr X:102,016,070...102,055,448
Ensembl chr X:97,722,802...97,761,853

G

calcium voltage-gated channel subunit alpha1 D

disease_progression

protein:increased expression:colon (human)

NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,228,306...5,668,215

G

calreticulin

RGD

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414

G

carbonic anhydrase 12

disease_progression

RGD

NCBI chr 8:76,169,723...76,225,465
Ensembl chr 8:67,274,359...67,330,440

G

chromodomain helicase DNA binding protein 4

ameliorates

human cells in a mouse model

RGD

NCBI chr 4:159,584,623...159,617,867
Ensembl chr 4:157,899,391...157,931,541

G

colony stimulating factor 1 receptor

ameliorates

mouse cell line in a mouse model
human cells in a mouse model

RGD

PMID:29436396 PMID:24898549 PMID:32304779

RGD:150524289, RGD:150524303, RGD:150524290

NCBI chr18:56,834,152...56,860,804
Ensembl chr18:54,546,659...54,590,415

G

colony stimulating factor 2

treatment

RGD

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199

G

catenin beta 1

DNA:mutation

RGD

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome P450, family 24, subfamily a, polypeptide 1

mRNA:increased expression:colonic mucosa (human)

RGD

NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:159,275,947...159,290,383

G

death-domain associated protein

protein:decreased expression:colon:

RGD

NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,970,092...4,975,843

G

eukaryotic translation elongation factor 2

protein:increased expression:colon(human)

RGD

NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:8,533,116...8,559,183

G

ferrochelatase

mRNA:decreased expression:colon

RGD

NCBI chr18:60,215,325...60,248,525
Ensembl chr18:57,945,122...57,979,348

G

FOS like 1, AP-1 transcription factor subunit

protein:increased expression:colon (human)

RGD

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:202,754,529...202,764,930

G

FOS like 2, AP-1 transcription factor subunit

protein:increased expression:colon (human)

RGD

NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:24,300,956...24,320,034

G

forkhead box A1

mRNA:decreased expression:colon

RGD

NCBI chr 6:80,838,380...80,871,195
Ensembl chr 6:75,103,503...75,136,188

G

GATA binding protein 1

RGD

NCBI chr X:17,193,291...17,209,462
Ensembl chr X:14,529,702...14,537,530

G

high mobility group box 1

RGD

NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

interleukin 21

treatment

RGD

NCBI chr 2:122,045,240...122,055,142
Ensembl chr 2:120,119,444...120,126,996

G

Janus kinase 2

treatment
ameliorates

Human cell in mouse model
human cells in mouse model

RGD

PMID:32504672 PMID:22050790

RGD:125097526, RGD:127285665

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189

G

lysine demethylase 6A

DNA:hypermethylation

RGD

NCBI chr X:6,920,374...7,060,027
Ensembl chr X:4,337,750...4,477,062

G

lysyl oxidase

ameliorates

RGD

NCBI chr18:48,162,889...48,175,640
Ensembl chr18:45,967,343...46,041,477

G

mitogen activated protein kinase kinase 7

human cell line and gene in a mouse model

RGD

NCBI chr12:7,389,032...7,398,377
Ensembl chr12:2,591,219...2,604,222

G

mitogen activated protein kinase 1

RGD

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

RGD

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

O-6-methylguanine-DNA methyltransferase

mRNA:decreased expression:colon (rat)

RGD

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756

G

microRNA 155

treatment

RGD

NCBI chr11:37,261,114...37,261,178
Ensembl chr11:23,774,654...23,774,718

G

matrix metallopeptidase 2

protein:increased expression:colon (human)

RGD

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

protein:increased expression:colon (human)

RGD

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

mutS homolog 6

ClinVar Annotator: match by term: Colon adenocarcinoma

NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:6,562,632...6,579,956

G

MYD88, innate immune signal transduction adaptor

exacerbates

human cell line in a mouse model

RGD

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415

G

NLR family, apoptosis inhibitory protein 6

exacerbates

mRNA:increased expression:colon (human)

NCBI chr 2:33,241,520...33,293,184
Ensembl chr 2:31,507,424...31,570,542

G

nitric oxide synthase 2

protein:increased expression:colon (human)

RGD

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

proprotein convertase subtilisin/kexin type 5

mRNA:decreased expression:colon:

RGD

NCBI chr 1:224,263,823...224,694,350
Ensembl chr 1:214,837,927...215,267,600

G

phosphoribosylformylglycinamidine synthase

RGD

NCBI chr10:54,189,157...54,210,685
Ensembl chr10:53,691,626...53,708,420

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

DNA:mutation

RGD

NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032

G

phosphoinositide-3-kinase regulatory subunit 3

treatment

RGD

NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:129,701,229...129,772,583

G

Rac family small GTPase 1

treatment

mRNA:alternative form

RGD

PMID:10597294 PMID:19561401

RGD:13432049, RGD:13432051

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251

G

RAD54 like

ClinVar Annotator: match by term: Colon adenocarcinoma

NCBI chr 5:134,812,158...134,841,821
Ensembl chr 5:129,575,378...129,605,070

G

ribonuclease L

severity

RGD

NCBI chr13:68,446,641...68,460,804
Ensembl chr13:65,901,459...65,908,704

G

ribonuclease T2

human cells in mouse model

RGD

NCBI chr 1:52,576,344...52,603,151
Ensembl chr 1:52,585,929...52,603,147

G

solute carrier family 22, member 18

ameliorates

mRNA:decreased expression:colorectum (human)

RGD

NCBI chr 1:208,100,032...208,124,382
Ensembl chr 1:198,671,731...198,694,975

G

structural maintenance of chromosomes 2

severity

human cell line in a mouse model

RGD

NCBI chr 5:71,592,428...71,648,636
Ensembl chr 5:66,807,011...66,853,242

G

SRC proto-oncogene, non-receptor tyrosine kinase

ameliorates

RGD

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476

G

serine and arginine rich splicing factor 4

mRNA:decreased expression:colon mucosa (human)

RGD

NCBI chr 5:144,060,981...144,090,798
Ensembl chr 5:144,061,463...144,089,229

G

serine and arginine rich splicing factor 5

mRNA:decreased expression:colon mucosa (human)

RGD

NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:100,605,456...100,610,177

G

serine and arginine rich splicing factor 6

mRNA:decreased expression:colon mucosa (human)

RGD

NCBI chr 3:172,009,072...172,014,395
Ensembl chr 3:151,589,535...151,594,860

G

signal transducer and activator of transcription 1

DNA:SNPs:introns: (rs2280232, rs4327257) (human)

RGD

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

treatment

human cells in mouse model
DNA:SNPs:introns: (rs12949918, rs6503695) (human)

RGD

PMID:32504672 PMID:22121102

RGD:125097526, RGD:153323313

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 5A

DNA:SNP:intron: (rs7217728) (human)

RGD

NCBI chr10:86,285,859...86,310,187
Ensembl chr10:85,785,537...85,809,866

G

signal transducer and activator of transcription 5B

DNA:SNPs:introns: (rs6503691, rs7218653) (human)

RGD

NCBI chr10:86,205,148...86,276,178
Ensembl chr10:85,705,670...85,775,668

G

signal transducer and activator of transcription 6

DNA:SNP:3' utr: (rs324015) (human)

RGD

NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:63,479,642...63,498,495

G

telomerase reverse transcriptase

treatment

RGD

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561

G

tet methylcytosine dioxygenase 2

mRNA:increased expression:colorectum, Cancer Stem-like Cells (human)

RGD

NCBI chr 2:224,662,654...224,746,819
Ensembl chr 2:221,988,645...222,072,534

G

transforming growth factor, beta 1

disease_progression

RGD

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

tumor protein p73

mRNA:increased expression:colon (human)

NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:164,621,377...164,681,128

G

ubiquitin protein ligase E3 component n-recognin 5

ameliorates
severity

human cell line in a mouse model

RGD

PMID:29296225 PMID:28856538

RGD:151665195, RGD:151665199

NCBI chr 7:71,000,197...71,109,841
Ensembl chr 7:69,116,761...69,224,903

G

vascular endothelial growth factor C

mRNA:increased expression:colon

RGD

NCBI chr16:44,445,293...44,560,887
Ensembl chr16:37,712,262...37,827,848

colon adenoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

axin 2

protein:increased expression::

RGD

NCBI chr10:94,393,379...94,426,579
Ensembl chr10:93,899,245...93,926,231

G

calcium voltage-gated channel subunit alpha1 D

protein:increased expression:colon (human)

NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,228,306...5,668,215

G

cyclin D1

severity

RGD

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

severity

RGD

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:159,962,363...159,989,495

G

choline kinase alpha

protein:increased expression:colonic mucosa (human)

RGD

NCBI chr 1:210,506,069...210,554,753
Ensembl chr 1:201,076,860...201,125,516

G

insulin-like growth factor 2 mRNA binding protein 1

RGD

NCBI chr10:81,405,021...81,447,814
Ensembl chr10:80,908,076...80,951,129

G

Rac family small GTPase 1

RGD

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251

G

retinol binding protein 4

protein:increased expression:blood serum (human)

RGD

NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:235,893,917...235,901,399

G

tet methylcytosine dioxygenase 2

mRNA:decreased expression:colon (human)

RGD

NCBI chr 2:224,662,654...224,746,819
Ensembl chr 2:221,988,645...222,072,534

colon cancer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alkaline ceramidase 3

severity

associated with colitis

RGD

NCBI chr 1:161,915,397...162,017,802
Ensembl chr 1:152,504,186...152,606,591

G

actin related protein 1A

RGD

NCBI chr 1:245,237,821...245,256,618
Ensembl chr 1:245,237,826...245,256,495

G

activin A receptor type 2A

RGD

NCBI chr 3:53,614,143...53,701,933
Ensembl chr 3:33,205,523...33,289,968

G

adenosine deaminase

susceptibility

DNA:polymorphisms,haplotypes: :
protein:increased activity:colon

RGD

PMID:20590444 PMID:15820509

RGD:152995263, RGD:152995289

NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088

G

AKT serine/threonine kinase 1

treatment
severity

human cells in mouse model
mRNA:increased expression:colon (human)

RGD

PMID:33360052 PMID:31932471 PMID:31932471

RGD:127229954, RGD:152995462, RGD:152995462

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 3

treatment

RGD

NCBI chr13:91,475,839...91,758,060
Ensembl chr13:88,946,091...89,225,708

G

apoptotic peptidase activating factor 1

treatment

RGD

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540

G

APC regulator of WNT signaling pathway

DNA:nonsense mutation:cds: c. 7621C > A (p.S2523X) (rat)
ClinVar Annotator: match by term: Colon cancer

PMID:22675565 PMID:25741868 PMID:26467025 PMID:26692440 PMID:26837502 More...

NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696

G

APC, WNT signaling pathway regulator; mutant 1, Kyo

RGD

G

apolipoprotein B mRNA editing enzyme catalytic subunit 1

mRNA, protein:decreased expression:colon

RGD

NCBI chr 4:157,472,879...157,500,496
Ensembl chr 4:155,800,887...155,827,390

G

AT-rich interaction domain 1A

treatment

human cells in mouse model

RGD

NCBI chr 5:151,192,014...151,269,291
Ensembl chr 5:145,908,181...145,985,564

G

autophagy related 101

disease_progression

RGD

NCBI chr 7:134,277,223...134,286,387
Ensembl chr 7:132,398,483...132,407,633

G

ATM serine/threonine kinase

ClinVar Annotator: match by term: Colon cancer

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437

G

ATR serine/threonine kinase

disease_progression

DNA:mutations: :

RGD

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:96,426,724...96,524,136

G

aurora kinase A

ClinVar Annotator: match by term: Colon cancer, susceptibility to

PMID:9771714 PMID:10511710 PMID:12881723 PMID:25741868

NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:161,128,313...161,144,390

G

axin 1

treatment

RGD

NCBI chr10:15,667,894...15,720,092
Ensembl chr10:15,163,684...15,215,615

G

alpha-2-glycoprotein 1, zinc-binding

severity

protein:increased expression:colon,serum

RGD

NCBI chr12:22,044,685...22,051,248
Ensembl chr12:16,931,024...16,939,091

G

BCL2-associated agonist of cell death

treatment

RGD

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823

G

BCL2, apoptosis regulator

treatment

RGD

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-interacting killer

treatment

RGD

NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:114,672,277...114,691,296

G

baculoviral IAP repeat-containing 3

disease_progression

protein:increased expression:colon (human)

RGD

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802

G

BRCA1, DNA repair associated

susceptibility
disease_progression

DNA:mutation

RGD

PMID:7907678 PMID:33583275

RGD:1599497, RGD:126925959

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304

G

bromodomain containing 4

RGD

NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,216,446...11,295,539

G

calreticulin

ameliorates
treatment

human cell line and recombinant gene in a mouse model
protein:increased expression:colon (human)

RGD

PMID:17187072 PMID:19256344 PMID:29573475 PMID:20480531 PMID:19881547

RGD:150521684, RGD:150521701, RGD:150521694, RGD:150521693, RGD:150521692

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414

G

caspase 3

disease_progression

protein:decreased expression:colon

RGD

PMID:17805550 PMID:23979166

RGD:13209142, RGD:13209143

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

disease_progression

RGD

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729

G

C-C motif chemokine ligand 2

RGD

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

RGD

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938

G

cyclin D2

mRNA:increased expression:colon

RGD

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:159,962,363...159,989,495

G

cyclin G2

mRNA:decreased expression:colon,rectum (human)

RGD

NCBI chr14:15,088,694...15,097,190
Ensembl chr14:14,804,322...14,812,830

G

CD274 molecule

treatment

RGD

NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:227,116,649...227,134,450

G

cadherin 1

ClinVar Annotator: match by term: Malignant tumor of colon

PMID:15235021 PMID:16924464 PMID:17545690 PMID:19268661 PMID:20233471 More...

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775

G

chromatin assembly factor 1 subunit A

disease_progression

mRNA,protein:increased expression:colonic mucosa:

RGD

PMID:24845563 PMID:24845563

RGD:9587457, RGD:9587457

NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654

G

checkpoint kinase 2

ClinVar Annotator: match by term: Colon cancer

PMID:15095295 PMID:21244692 PMID:22114986 PMID:22419737 PMID:22862163 More...

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286

G

choline kinase alpha

mRNA, protein:increased expression:colon (rat)

RGD

NCBI chr 1:210,506,069...210,554,753
Ensembl chr 1:201,076,860...201,125,516

G

component of inhibitor of nuclear factor kappa B kinase complex

protein:increased expression:colon (human)

RGD

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065

G

collagen type VI alpha 3 chain

protein:increased expression:serum (human)

RGD

NCBI chr 9:98,809,171...98,887,060
Ensembl chr 9:91,361,583...91,439,471

G

cripto, EGF-CFC family member

treatment

RGD

NCBI chr 8:119,803,182...119,808,714
Ensembl chr 8:110,925,024...110,930,308

G

C-reactive protein

protein:increased expression:serum:

RGD

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178

G

casein kinase 1, delta

mRNA:increased expression:colon

RGD

NCBI chr10:106,713,497...106,754,953
Ensembl chr10:106,221,992...106,256,614

G

casein kinase 1, epsilon

mRNA:increased expression:colon

RGD

NCBI chr 7:112,863,726...112,887,338
Ensembl chr 7:110,983,318...111,006,794

G

cytochrome P450, family 24, subfamily a, polypeptide 1

susceptibility

mRNA:increased expression:colon (human)
DNA:SNPs:introns: (rs4809960, rs6022999) (human)
DNA:SNPs:multiple (human)
DNA:SNP:intron: IVS4-66T>G, (rs4809958) (human)

RGD

PMID:16180015 PMID:31740231 PMID:28811712 PMID:19706847

RGD:151361183, RGD:151665338, RGD:151665177, RGD:151665174

NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 2, subfamily e, polypeptide 1

treatment

RGD

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023

G

cysteinyl leukotriene receptor 1

associated with Experimental Colitis

RGD

NCBI chr X:75,734,281...75,762,873
Ensembl chr X:71,663,821...71,690,121

G

elongation factor Tu GTP binding domain containing 2

ameliorates

associated with colitis;

RGD

NCBI chr10:88,304,992...88,352,229
Ensembl chr10:87,804,892...87,846,079

G

estrogen receptor 2

RGD

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

disease_progression

RGD

NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:76,624,399...76,687,362

G

fibroblast growth factor receptor 4

treatment

human cells in mouse model

RGD

NCBI chr17:9,466,686...9,481,423
Ensembl chr17:9,461,547...9,476,242

G

glutathione peroxidase 1

treatment

associated with Inflammation
mRNA, protein:increased expression:colon (human)

RGD

PMID:28045589 PMID:21868509

RGD:152995480, RGD:152995496

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

treatment

associated with Inflammation

RGD

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 3

disease_progression

associated with Experimental Colitis

RGD

NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,028,570...39,037,035

G

glutathione peroxidase 4

disease_progression

mRNA, protein:increased expression:colon (human)

RGD

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:9,650,185...9,652,982

G

glycogen synthase kinase 3 beta

treatment

RGD

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646

G

heparan sulfate-glucosamine 3-sulfotransferase 2

DNA:hypermethylation:promoter (human)

RGD

NCBI chr 1:185,387,445...185,508,700
Ensembl chr 1:175,956,157...176,077,399

G

heat shock protein 90 alpha family class A member 1

protein:increased expression:colon (human)

RGD

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:129,702,383...129,707,268

G

HtrA serine peptidase 1

disease_progression

DNA:SNP:cds: (rs1049331) (human)

RGD

NCBI chr 1:194,928,069...194,977,619
Ensembl chr 1:185,497,735...185,547,379

G

inhibitor of nuclear factor kappa B kinase subunit beta

associated with Obesity;protein:increased expression:large intestine mucosa

RGD

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10

no_association

DNA:SNP:promoter:-592C>A (rs1800872) (human)
DNA:SNP: :rs1800896 (human)

RGD

PMID:27468578 PMID:27468578

RGD:11534627, RGD:11534627

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 33

treatment

associated with colitis;

RGD

NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373

G

interleukin 7 receptor

disease_progression

DNA:deletion: :

RGD

NCBI chr 2:60,179,561...60,204,937
Ensembl chr 2:58,454,217...58,477,757

G

Janus kinase 2

treatment

RGD

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189

G

JunB proto-oncogene, AP-1 transcription factor subunit

RNA:decreased expression:colon (human)

RGD

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035

G

lysine demethylase 3A

severity

human gene in a mouse model

RGD

NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:103,630,908...103,675,073

G

lysine demethylase 5C

mRNA:increased expression:colon (human)

RGD

NCBI chr X:24,821,568...24,866,423
Ensembl chr X:21,345,481...21,381,870

G

lactalbumin, alpha

onset

RGD

NCBI chr 7:129,625,531...129,628,034
Ensembl chr 7:129,625,535...129,628,061

G

lipocalin 2

treatment

RGD

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095

G

galectin 3

treatment

RGD

NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025

G

LIF, interleukin 6 family cytokine

ameliorates

human cells in mouse model

RGD

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482

G

LDL receptor related protein 1B

human cells in a mouse moel

RGD

NCBI chr 3:45,004,001...47,125,147
Ensembl chr 3:24,594,991...26,715,505

G

mitogen activated protein kinase kinase 3

RGD

NCBI chr10:46,107,639...46,128,986
Ensembl chr10:45,607,163...45,629,492

G

mitogen activated protein kinase kinase 7

mRNA:splice variant:exon 2: (human)

RGD

NCBI chr12:7,389,032...7,398,377
Ensembl chr12:2,591,219...2,604,222

G

mitogen activated protein kinase 1

treatment

RGD

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

susceptibility

DNA:SNP:intron: (rs10807156) (human)
DNA:SNP:intron: (rs851016) (human)

RGD

PMID:23859041 PMID:23027623

RGD:150573807, RGD:13217411

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589

G

MCL1 apoptosis regulator, BCL2 family member

ameliorates

human cells in mouse model

RGD

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303

G

microRNA 10a

disease_progression

human cells in mouse model;RNA:increased expression:colon,exosome (human)

RGD

NCBI chr10:81,779,709...81,779,818
Ensembl chr10:81,283,171...81,283,280

G

microRNA 126a

disease_progression

human cells in mouse model;RNA:increased expression:colon,exosome (human)

PMID:18663744 PMID:28211508

RGD:13432043, RGD:153344546

NCBI chr 3:29,813,150...29,813,267
Ensembl chr 3:9,415,063...9,415,180

G

microRNA 126b

RGD

NCBI chr 3:29,813,174...29,813,246

G

microRNA 136

disease_progression

RNA:decreased expression:colon (human)

RGD

PMID:28710032 PMID:29339925

RGD:153344627, RGD:153345546

NCBI chr 6:134,331,335...134,331,416
Ensembl chr 6:128,549,096...128,549,177

G

microRNA 143

disease_progression

RNA:decreased expression:peripheral blood mononuclear cell (human)

RGD

NCBI chr18:57,371,349...57,371,453
Ensembl chr18:55,101,006...55,101,110

G

microRNA 145

RNA:increased expression:peripheral blood mononuclear cell (human)

RGD

NCBI chr18:57,369,983...57,370,070
Ensembl chr18:55,099,640...55,099,727

G

microRNA 148a

disease_progression

human cells in mouse model;RNA:increased expression:colon,exosome (human)

RGD

NCBI chr 4:81,664,431...81,664,527
Ensembl chr 4:80,333,762...80,333,858

G

microRNA 151

disease_progression

human cells in mouse model;RNA:decreased expression:colon,exosome (human)

RGD

NCBI chr 7:107,061,380...107,061,476

G

microRNA 155

treatment

miRNA:increased expression:colon

RGD

PMID:29552117 PMID:26744471 PMID:29552117

RGD:21081546, RGD:11520828, RGD:21081546

NCBI chr11:37,261,114...37,261,178
Ensembl chr11:23,774,654...23,774,718

G

microRNA 193a

ameliorates
exacerbates

human cells in mouse model

RGD

PMID:28211508 PMID:30575330

RGD:153344546, RGD:153344588

NCBI chr10:65,170,306...65,170,417
Ensembl chr10:64,672,343...64,672,454

G

microRNA 196a-1

disease_progression

human cells in mouse model;RNA:decreased expression:colon,exosome (human)

NCBI chr10:81,231,006...81,231,085
Ensembl chr10:81,231,006...81,231,085

G

microRNA 196b

disease_progression

human cells in mouse model;RNA:decreased expression:colon,exosome (human)

RGD

NCBI chr 4:82,661,101...82,661,185
Ensembl chr 4:81,330,487...81,330,571

G

microRNA 200b

human cells in mouse model;RNA:increased expression:colon,exosome (human)

RGD

NCBI chr 5:171,931,495...171,931,589
Ensembl chr 5:166,649,272...166,649,366

G

microRNA 21

disease_progression

RNA:increased expression:colon (human)
RNA:increased expression:peripheral blood mononuclear cell (human)

RGD

PMID:27798874 PMID:32104069

RGD:152995486, RGD:153297766

NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348

G

microRNA 22

disease_progression

human cells in mouse model;RNA:increased expression:colon,exosome (human)

RGD

NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,307,039...60,307,133

G

microRNA 30b

disease_progression

human cells in mouse model;RNA:increased expression:colon,exosome (human)

RGD

NCBI chr 7:102,021,543...102,021,629
Ensembl chr 7:100,132,589...100,132,675

G

marker of proliferation Ki-67

treatment

RGD

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762

G

mutL homolog 1

disease_progression

ClinVar Annotator: match by term: Colon cancer | ClinVar Annotator: match by term: Malignant tumor of colon

PMID:8566964 PMID:8574961 PMID:8592341 PMID:08808596 PMID:9311737 More...

NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:111,196,468...111,233,617

G

matrix metallopeptidase 3

treatment

RGD

NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:4,640,416...4,653,961

G

MRE11 homolog, double strand break repair nuclease

susceptibility

DNA:SNP:3'utr: (rs2155209) (human)

RGD

NCBI chr 8:19,900,211...19,961,906
Ensembl chr 8:11,632,354...11,678,279

G

mutS homolog 2

disease_progression
no_association

DNA, mRNA:loss of heterogeneity, increased expression: :colon
ClinVar Annotator: match by term: Colon cancer
DNA:SNP:intron:IVS10+12G>A (human)

PMID:25741868 PMID:28492532 PMID:33357406 PMID:29715107 PMID:28411881 More...

RGD:126790554, RGD:126790577, RGD:126790554

NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938

G

mechanistic target of rapamycin kinase

treatment

RGD

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

microtubule associated scaffold protein 1

mRNA, protein:decreased expression:colon (human)

RGD

NCBI chr16:57,905,991...58,051,466
Ensembl chr16:51,253,562...51,347,793

G

mucin 2, oligomeric mucus/gel-forming

mRNA:decreased expression:colon
protein:decreased expression:colon

RGD

PMID:20459814 PMID:17847023

RGD:7349368, RGD:7349371

NCBI chr 1:206,225,775...206,261,280
Ensembl chr 1:196,799,517...196,831,756

G

mutY DNA glycosylase

ClinVar Annotator: match by term: Colon cancer | ClinVar Annotator: match by term: Malignant tumor of colon

PMID:2914711 PMID:9536098 PMID:11818965 PMID:12606733 PMID:12853198 More...

NCBI chr 5:135,510,666...135,522,777
Ensembl chr 5:130,274,122...130,286,146

G

MYC binding protein 2

disease_progression

RGD

NCBI chr15:86,352,061...86,590,126
Ensembl chr15:79,937,354...80,175,498

G

MYD88, innate immune signal transduction adaptor

ameliorates

RGD

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415

G

Nanog homeobox

treatment

RGD

NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:155,943,737...155,951,116

G

nuclear receptor coactivator 6

DNA:amplification:cds (human)

RGD

NCBI chr 3:164,351,062...164,422,079
Ensembl chr 3:143,890,896...143,952,268

G

neurofibromin 1

mRNA:increased expression:colon (human)

RGD

NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,306,301...64,536,658

G

NAD(P)H quinone dehydrogenase 1

RGD

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 5, group A, member 2

RNA:increased expression:colon (human)

NCBI chr13:50,865,253...50,985,107
Ensembl chr13:48,316,301...48,433,326

G

phosphoinositide-3-kinase regulatory subunit 2

RGD

NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,665,457...18,674,065

G

phosphoinositide-3-kinase, regulatory subunit 5

DNA:hypermethylation

RGD

NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,132,603...53,199,374

G

PKHD1 ciliary IPT domain containing fibrocystin/polyductin

ClinVar Annotator: match by term: Malignant tumor of colon

PMID:12846734 PMID:14741187 PMID:15805161 PMID:21493627 PMID:25646624 More...

NCBI chr 9:22,547,396...23,037,443
Ensembl chr 9:22,549,513...23,037,381

G

phospholipase C, gamma 1

treatment

RGD

NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:149,385,587...149,416,330

G

polo-like kinase 4

protein:increased expression:colon

RGD

NCBI chr 2:125,730,480...125,748,894
Ensembl chr 2:123,802,512...123,820,942

G

PMS1 homolog 2, mismatch repair system component

ClinVar Annotator: match by term: Colon cancer

PMID:21376568 PMID:24362816 PMID:25741868 PMID:28492532 PMID:30376427 More...

NCBI chr12:15,790,478...15,814,790
Ensembl chr12:10,676,764...10,701,066

G

DNA polymerase delta 1, catalytic subunit

ClinVar Annotator: match by term: Malignant tumor of colon

PMID:25741868 PMID:26467025 PMID:28492532

NCBI chr 1:104,161,984...104,178,074
Ensembl chr 1:95,025,499...95,036,465

G

DNA polymerase epsilon, catalytic subunit

ClinVar Annotator: match by term: Colon cancer

PMID:25741868 PMID:28492532

NCBI chr12:52,005,155...52,053,761
Ensembl chr12:46,345,420...46,393,939

G

peroxisome proliferator-activated receptor gamma

DNA:frameshift mutation:c.472delA (human)

RGD

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

protein kinase AMP-activated catalytic subunit alpha 1

RGD

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978

G

phosphatase and tensin homolog

mRNA:decreased expression:colon (human)

RGD

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin E receptor 3

mRNA:decreased expression:colon mucosa (rat)

RGD

NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:246,606,183...246,684,434

G

prostaglandin I2 synthase

exacerbates

RGD

NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:155,916,412...155,965,451

G

protein tyrosine phosphatase, non-receptor type 13

treatment

RGD

NCBI chr14:6,412,841...6,587,238
Ensembl chr14:6,108,211...6,282,563

G

protein tyrosine phosphatase, receptor type, T

exacerbates

RGD

PMID:20133777 PMID:27447856

RGD:150520184, RGD:150520192

NCBI chr 3:170,608,993...171,707,692
Ensembl chr 3:150,194,859...151,288,124

G

RAD52 homolog, DNA repair protein

susceptibility

DNA:SNPs:3'utr: (rs1051669, rs11571475) (human)

RGD

NCBI chr 4:154,778,320...154,802,002
Ensembl chr 4:153,106,062...153,128,207

G

regenerating family member 1 alpha

mRNA:increased expression:colon mucosa (human)

RGD

NCBI chr 4:112,450,466...112,453,130
Ensembl chr 4:110,892,453...110,895,570

G

RPTOR independent companion of MTOR, complex 2

severity

protein:increased expression:colon (human)
human cells in mouse model
mRNA:increased expression:colon (human)

RGD

PMID:24244675 PMID:20226010 PMID:31932471

RGD:152995458, RGD:152995494, RGD:152995462

NCBI chr 2:57,539,279...57,631,291
Ensembl chr 2:55,811,322...55,901,426

G

ribonuclease T2

RGD

NCBI chr 1:52,576,344...52,603,151
Ensembl chr 1:52,585,929...52,603,147

G

ring finger protein 43

disease_progression

mRNA:increased expression:colon (human)

RGD

NCBI chr10:72,958,744...73,034,540
Ensembl chr10:72,464,348...72,536,977

G

ribosomal protein S6 kinase B1

treatment

RGD

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908

G

solute carrier family 7 member 5

treatment

RGD

NCBI chr19:66,843,808...66,872,412
Ensembl chr19:49,935,220...49,963,823

G

solute carrier organic anion transporter family member 1B2

disease_progression

mRNA:increased expression:colon (human)

RGD

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:174,551,480...174,619,981

G

SMAD family member 2

treatment

RGD

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 4

treatment
severity

mRNA:decreased expression:colon (human)

RGD

PMID:33360052 PMID:31932471

RGD:127229954, RGD:152995462

NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438

G

smoothened, frizzled class receptor

protein:increased expression:colon

RGD

NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:58,343,529...58,373,829

G

suppressor of cytokine signaling 1

ameliorates

RGD

NCBI chr10:5,389,574...5,391,265
Ensembl chr10:4,882,560...4,884,383

G

SRC proto-oncogene, non-receptor tyrosine kinase

disease_progression

DNA:nonsense mutation
ClinVar Annotator: match by term: Colon cancer, advanced

PMID:9988270 PMID:9988270 PMID:7678609

RGD:1601371, RGD:150521542

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476

G

serine and arginine rich splicing factor 1

protein:increased expression:colon (human)

RGD

NCBI chr10:73,335,519...73,342,549
Ensembl chr10:72,839,274...72,845,336

G

signal transducer and activator of transcription 3

treatment
ameliorates

human cells in mouse model

RGD

PMID:33360052 PMID:29899555

RGD:127229954, RGD:151356919

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

trefoil factor 3

protein:decreased expression:colon

RGD

NCBI chr20:9,194,623...9,199,333
Ensembl chr20:9,193,262...9,198,054

G

transforming growth factor, beta 1

treatment

RGD

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 3

disease_progression

RGD

NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:105,704,236...105,726,564

G

transforming growth factor, beta receptor 2

RGD

NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228

G

TLE family member 5, transcriptional modulator

mRNA:decreased expression:colon

RGD

NCBI chr 7:8,794,123...8,801,056
Ensembl chr 7:8,143,357...8,150,113

G

TNF alpha induced protein 3

treatment

protein:decreased expression:colon (human)
mRNA,protein:increased expression:colon (human)
associated with Experimental Colitis

RGD

PMID:27991929 PMID:24099634 PMID:27991929

RGD:151347529, RGD:151347624, RGD:151347529

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282

G

TNF receptor superfamily member 10b

disease_progression

mRNA:increased expression:colon

RGD

NCBI chr15:51,249,883...51,278,091
Ensembl chr15:44,840,386...44,867,467

G

ubiquitin protein ligase E3 component n-recognin 5

exacerbates

mRNA:increased expression:colon (human)

RGD

NCBI chr 7:71,000,197...71,109,841
Ensembl chr 7:69,116,761...69,224,903

G

vascular endothelial growth factor A

RGD

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

G

Wnt family member 5A

treatment

RGD

NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,697,032...3,718,234

G

X-ray repair cross complementing 2

ClinVar Annotator: match by term: Colon cancer

PMID:23054243 PMID:25637381 PMID:25741868 PMID:27233470 PMID:28492532 More...

NCBI chr 4:10,157,130...10,237,089
Ensembl chr 4:9,423,898...9,442,482

colon carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

ClinVar Annotator: match by term: Carcinoma of colon

PMID:17611497 PMID:18954143 PMID:21793738 PMID:23237847 PMID:25741868 More...

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

aminopeptidase O

ClinVar Annotator: match by term: Carcinoma of colon

PMID:25058500 PMID:27165003

NCBI chr17:1,817,001...2,133,008
Ensembl chr17:1,811,980...2,127,331

G

APC regulator of WNT signaling pathway

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma | ClinVar Annotator: match by term: Colonic carcinoma

PMID:1316610 PMID:1324223 PMID:1338764 PMID:1338904 PMID:1528264 More...

NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696

G

ATM serine/threonine kinase

ClinVar Annotator: match by term: Carcinoma of colon
ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colonic carcinoma

PMID:8845835 PMID:9792409 PMID:9887333 PMID:10425038 PMID:10817650 More...

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437

G

axin 2

protein:increased expression:colon mucosa:
ClinVar Annotator: match by term: Carcinoma of colon

PMID:11017067 PMID:15042511 PMID:21416598 PMID:25741868 PMID:28492532 More...

NCBI chr10:94,393,379...94,426,579
Ensembl chr10:93,899,245...93,926,231

G

BRCA1 associated RING domain 1

ClinVar Annotator: match by term: Carcinoma of colon

PMID:19197335 PMID:20077502 PMID:25741868 PMID:26350354 PMID:26467025 More...

NCBI chr 9:80,069,960...80,144,167
Ensembl chr 9:72,623,155...72,694,265

G

BCL2 associated X, apoptosis regulator

ClinVar Annotator: match by term: Carcinoma of colon

PMID:9020077 PMID:9453486 PMID:9531611 PMID:10984511

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL10, immune signaling adaptor

ClinVar Annotator: match by term: Carcinoma of colon

NCBI chr 2:237,501,181...237,510,821
Ensembl chr 2:234,840,858...234,850,523

G

bone morphogenetic protein receptor type 1A

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colonic carcinoma

PMID:12417513 PMID:14526373 PMID:15235019 PMID:18823382 PMID:23399955 More...

NCBI chr16:9,740,751...9,786,861
Ensembl chr16:9,736,630...9,780,616

G

B-Raf proto-oncogene, serine/threonine kinase

treatment

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma

PMID:12068308 PMID:12198537 PMID:12447372 PMID:12619120 PMID:12644542 More...

NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463

G

BRCA1, DNA repair associated

ClinVar Annotator: match by term: Carcinoma of colon

PMID:25741868 PMID:26295337 PMID:26467025 PMID:28492532 PMID:31911673 More...

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304

G

BRCA2, DNA repair associated

ClinVar Annotator: match by term: Carcinoma of colon

PMID:11030418 PMID:12491487 PMID:15744044 PMID:15937982 PMID:15983021 More...

NCBI chr12:4,895,092...4,939,340
Ensembl chr12:59,819...100,567

G

BRCA1 interacting DNA helicase 1

ClinVar Annotator: match by term: Carcinoma of colon

PMID:16116423 PMID:16280053 PMID:17033622 PMID:18483852 PMID:21964575 More...

NCBI chr10:71,402,035...71,528,083
Ensembl chr10:70,907,371...71,030,324

G

BUB1 mitotic checkpoint serine/threonine kinase

ClinVar Annotator: match by term: Carcinoma of colon

NCBI chr 3:135,473,525...135,504,921
Ensembl chr 3:115,020,254...115,051,650

G

BUB1 mitotic checkpoint serine/threonine kinase B

ClinVar Annotator: match by term: Carcinoma of colon

PMID:9521327 PMID:24728327 PMID:25741868 PMID:28492532

NCBI chr 3:126,017,019...126,069,470
Ensembl chr 3:105,563,138...105,615,547

G

similar to human chromosome 11 open reading frame 65

ClinVar Annotator: match by term: Carcinoma of colon

PMID:8845835 PMID:17910737 PMID:19404735 PMID:20305132 PMID:21665257 More...

NCBI chr 8:62,692,123...62,720,951
Ensembl chr 8:53,796,366...53,824,748

G

calreticulin

treatment

human cells and recombinant protein in a mouse model

RGD

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414

G

cadherin 1

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colonic carcinoma

PMID:25583476 PMID:25741868 PMID:26467025 PMID:28492532 PMID:30287823 More...

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775

G

checkpoint kinase 2

ClinVar Annotator: match by term: Carcinoma of colon

PMID:14612911 PMID:15087378 PMID:17721994 PMID:18571837 PMID:21244692 More...

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286

G

CRK like proto-oncogene, adaptor protein

RGD

NCBI chr11:97,033,033...97,067,457
Ensembl chr11:83,526,530...83,563,238

G

catenin beta 1

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma

PMID:9065402 PMID:9294210 PMID:10192393 PMID:23033978 PMID:24614104 More...

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 10

treatment

RGD

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 6

disease_progression

RGD

NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,310,426...17,313,093

G

DCC netrin 1 receptor

ClinVar Annotator: match by term: Carcinoma of colon

NCBI chr18:67,144,272...68,248,159
Ensembl chr18:64,873,898...65,972,740

G

DLC1 Rho GTPase activating protein

ClinVar Annotator: match by term: Carcinoma of colon

NCBI chr16:61,954,177...62,374,819
Ensembl chr16:55,291,584...55,671,439

G

ephrin B2

ameliorates

human cells in mouse model

RGD

NCBI chr16:87,485,215...87,529,224
Ensembl chr16:80,783,417...80,824,391

G

E1A binding protein p300

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma

PMID:10700188 PMID:25741868

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

epithelial cell adhesion molecule

ClinVar Annotator: match by term: Carcinoma of colon

NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:6,878,237...6,896,127

G

FA complementation group C

ClinVar Annotator: match by term: Carcinoma of colon

PMID:25058500 PMID:27165003

NCBI chr17:1,686,374...1,818,672
Ensembl chr17:1,681,324...1,829,376

G

FA complementation group E

ClinVar Annotator: match by term: Carcinoma of colon

PMID:25058500 PMID:25741868 PMID:27165003 PMID:28492532 PMID:34687117

NCBI chr20:6,369,416...6,386,631
Ensembl chr20:6,375,573...6,386,631

G

fibroblast growth factor receptor 3

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma

PMID:1908846 PMID:7649548 PMID:7670477 PMID:7702086 PMID:7773297 More...

NCBI chr14:81,211,800...81,227,215
Ensembl chr14:76,987,993...77,003,341

G

folliculin

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma | ClinVar Annotator: match by term: Colonic carcinoma

PMID:12843323 PMID:15805188 PMID:15852235 PMID:16199547 PMID:18234728 More...

NCBI chr10:45,088,164...45,107,581
Ensembl chr10:44,588,624...44,607,769

G

Fms related receptor tyrosine kinase 1

ClinVar Annotator: match by term: Carcinoma of colon

NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626

G

Fms related receptor tyrosine kinase 3 ligand

treatment

RGD

NCBI chr 1:104,751,518...104,756,925
Ensembl chr 1:95,609,370...95,620,463

G

Fms related receptor tyrosine kinase 4

ClinVar Annotator: match by term: Carcinoma of colon

PMID:25741868 PMID:28492532

NCBI chr10:34,414,834...34,455,878
Ensembl chr10:33,913,608...33,954,770

G

forkhead box A1

disease_progression

RGD

NCBI chr 6:80,838,380...80,871,195
Ensembl chr 6:75,103,503...75,136,188

G

15-hydroxyprostaglandin dehydrogenase

DNA:::adenoviral delivery of human gene in mouse model of colon cancer

RGD

NCBI chr16:38,996,876...39,034,831
Ensembl chr16:33,986,266...34,024,228

G

insulin-like growth factor 2 receptor

protein:increased expression:serum:

RGD

NCBI chr 1:50,526,878...50,615,265
Ensembl chr 1:47,979,109...48,067,501

G

kinase insert domain receptor

treatment

ClinVar Annotator: match by term: Carcinoma of colon

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018

G

lysine methyltransferase 2D

protein:increased expression:colon

RGD

NCBI chr 7:131,859,696...131,901,032
Ensembl chr 7:129,962,887...130,020,325

G

MCC regulator of WNT signaling pathway

ClinVar Annotator: match by term: Carcinoma of colon

NCBI chr18:36,794,206...37,266,237
Ensembl chr18:36,798,372...37,266,819

G

mutL homolog 1

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma | ClinVar Annotator: match by term: Colonic carcinoma

PMID:7757073 PMID:8521398 PMID:8571956 PMID:8574961 PMID:8581513 More...

NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:111,196,468...111,233,617

G

mutL homolog 3

ClinVar Annotator: match by term: Carcinoma of colon

PMID:11317354 PMID:28492532 PMID:35292633

NCBI chr 6:110,612,535...110,649,408
Ensembl chr 6:104,881,483...104,917,728

G

mutS homolog 2

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma | ClinVar Annotator: match by term: Colonic carcinoma

PMID:187139 PMID:625353 PMID:3258778 PMID:3616036 PMID:6096739 More...

NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938

G

mutS homolog 6

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma | ClinVar Annotator: match by term: Colonic carcinoma

PMID:1548301 PMID:3049887 PMID:8838326 PMID:9345684 PMID:9536098 More...

NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:6,562,632...6,579,956

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

ClinVar Annotator: match by term: Carcinoma of colon

PMID:9299504 PMID:9806551 PMID:10519336 PMID:10521313 PMID:13298683 More...

NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694

G

mutY DNA glycosylase

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma | ClinVar Annotator: match by term: Colonic carcinoma

PMID:517270 PMID:2914711 PMID:9536098 PMID:11051386 PMID:11295288 More...

NCBI chr 5:135,510,666...135,522,777
Ensembl chr 5:130,274,122...130,286,146

G

MYD88, innate immune signal transduction adaptor

treatment

mouse cell line in a mouse model

RGD

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415

G

nibrin

ClinVar Annotator: match by term: Colonic carcinoma

PMID:11325820 PMID:14559852 PMID:15338273 PMID:16474176 PMID:16810201 More...

NCBI chr 5:34,256,678...34,291,163
Ensembl chr 5:29,459,457...29,494,150

G

NRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Carcinoma of colon

PMID:3102434 PMID:18633438 PMID:25741868

NCBI chr 2:193,271,399...193,282,023
Ensembl chr 2:190,582,918...190,591,626

G

partner and localizer of BRCA2

ClinVar Annotator: match by term: Carcinoma of colon
ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma | ClinVar Annotator: match by term: Colonic carcinoma

PMID:3040479 PMID:18053174 PMID:21285249 PMID:21365267 PMID:21618343 More...

NCBI chr 1:186,096,312...186,120,284
Ensembl chr 1:176,665,076...176,688,990

G

platelet derived growth factor receptor alpha

ClinVar Annotator: match by term: Carcinoma of colon

PMID:24033266 PMID:25741868 PMID:28492532

NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,005,839...33,054,335

G

platelet-derived growth factor receptor-like

ClinVar Annotator: match by term: Carcinoma of colon

NCBI chr16:58,051,421...58,111,327
Ensembl chr16:51,347,948...51,407,850

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

ClinVar Annotator: match by term: Colon carcinoma | ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma | ClinVar Annotator: match by term: Colonic carcinoma

PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 More...

NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032

G

PMS1 homolog 2, mismatch repair system component

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma | ClinVar Annotator: match by term: Colonic carcinoma

PMID:285143 PMID:2402700 PMID:9536098 PMID:9683794 PMID:10037723 More...

NCBI chr12:15,790,478...15,814,790
Ensembl chr12:10,676,764...10,701,066

G

DNA polymerase delta 1, catalytic subunit

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma | ClinVar Annotator: match by term: Colonic carcinoma

PMID:15322521 PMID:15766587 PMID:19966286 PMID:25032700 PMID:25637381 More...

NCBI chr 1:104,161,984...104,178,074
Ensembl chr 1:95,025,499...95,036,465

G

DNA polymerase epsilon, catalytic subunit

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma | ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colonic carcinoma

PMID:15766587 PMID:16199547 PMID:23230001 PMID:23263490 PMID:23447401 More...

NCBI chr12:52,005,155...52,053,761
Ensembl chr12:46,345,420...46,393,939

G

peroxisome proliferator-activated receptor gamma

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma

PMID:10394368 PMID:25741868

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

perforin 1

RGD

NCBI chr20:29,789,040...29,794,550
Ensembl chr20:29,246,202...29,251,701

G

phosphatase and tensin homolog

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colonic carcinoma

PMID:10555148 PMID:12372056 PMID:21194675 PMID:21659347 PMID:21956414 More...

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838

G

protein tyrosine phosphatase, non-receptor type 12

ClinVar Annotator: match by term: Carcinoma of colon

NCBI chr 4:14,020,997...14,092,931
Ensembl chr 4:14,021,052...14,092,927

G

protein tyrosine phosphatase, receptor type, J

ClinVar Annotator: match by term: Carcinoma of colon

PMID:12089527 PMID:25741868 PMID:33116287

NCBI chr 3:96,861,785...97,017,702
Ensembl chr 3:76,405,927...76,562,260

G

RAD51 paralog C

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colonic carcinoma

PMID:16199547 PMID:20400964 PMID:21537932 PMID:21990120 PMID:22538716 More...

NCBI chr10:72,702,299...72,728,980
Ensembl chr10:72,205,032...72,231,248

G

RAD51 paralog D

ClinVar Annotator: match by term: Carcinoma of colon

PMID:25741868 PMID:28492532

NCBI chr10:68,303,350...68,322,002
Ensembl chr10:67,740,712...67,824,434

G

RAD54 homolog B

ClinVar Annotator: match by term: Carcinoma of colon

NCBI chr 5:29,829,465...29,901,967
Ensembl chr 5:25,032,066...25,104,616

G

REV3 like, DNA directed polymerase zeta catalytic subunit

ClinVar Annotator: match by term: Carcinoma of colon

PMID:25058500 PMID:27165003

NCBI chr20:44,686,482...44,844,668
Ensembl chr20:43,132,363...43,290,099

G

RT1 class II, locus Ba

susceptibility

DNA:polymorphism: :HLA-DQA1*0201 (human)

RGD

NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,575,134...4,579,744

G

solute carrier organic anion transporter family member 1B2

mRNA,protein:increased expression:colon (human)

RGD

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:174,551,480...174,619,981

G

SMAD family member 4

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colonic carcinoma

PMID:9582123 PMID:10398437 PMID:11920286 PMID:15235019 PMID:16152648 More...

NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438

G

SRC proto-oncogene, non-receptor tyrosine kinase

protein:increased phosphorylating activity:colon mucosa

RGD

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476

G

serine/threonine kinase 11

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colonic carcinoma

PMID:14623934 PMID:15121768 PMID:25186949 PMID:25741868 PMID:26467025 More...

NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:9,575,269...9,591,315

G

transforming growth factor, beta 1

disease_progression

RGD

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

disease_progression

RGD

PMID:11166150 PMID:10416598

RGD:13432074, RGD:13432084

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405

G

toll-like receptor 3

protein:increased expression:colon

RGD

NCBI chr16:53,554,916...53,572,321
Ensembl chr16:46,822,039...46,836,545

G

TNF receptor superfamily member 17

RGD

NCBI chr10:4,808,023...4,813,857
Ensembl chr10:4,301,038...4,306,788

G

TNF receptor superfamily member 1A

protein:increased expression:serum (human)

RGD

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

protein:increased expression:serum (human)

RGD

NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206

G

target of EGR1, exonuclease

ClinVar Annotator: match by term: Carcinoma of colon

PMID:18271935 PMID:25741868 PMID:28492532

NCBI chr 5:130,270,484...130,274,050
Ensembl chr 5:130,262,319...130,274,050

G

tumor protein p53

ClinVar Annotator: match by term: Carcinoma of colon | ClinVar Annotator: match by term: Colon carcinoma | ClinVar Annotator: match by term: Colonic carcinoma

PMID:1565143 PMID:1683921 PMID:1978757 PMID:2932480 PMID:7887414 More...

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

thymidylate synthetase

human tumor in mouse model

RGD

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536

G

ubiquitin A-52 residue ribosomal protein fusion product 1

mRNA:increased expression:colonic mucosa (human)

RGD

NCBI chr16:18,952,583...18,954,780
Ensembl chr16:18,900,616...18,920,807

G

vascular endothelial growth factor A

treatment

RGD

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

colon signet ring adenocarcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RUNX family transcription factor 1

mRNA:increased expression:colon

RGD

NCBI chr11:45,325,778...45,560,300
Ensembl chr11:31,843,764...32,074,542

descending colon cancer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

lysine demethylase 5C

onset

associate with colorectal cancer;DNA:mutations:multiple (human)

RGD

NCBI chr X:24,821,568...24,866,423
Ensembl chr X:21,345,481...21,381,870

sigmoid colon cancer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

APC regulator of WNT signaling pathway

ClinVar Annotator: match by term: Sigmoid colon cancer

PMID:25741868 PMID:28492532

NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696

G

mutS homolog 2

ClinVar Annotator: match by term: Sigmoid colon cancer

PMID:10495924 PMID:12658575 PMID:15849733 PMID:17312306 PMID:18566915 More...

NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938

G

mutS homolog 6

ClinVar Annotator: match by term: Sigmoid colon cancer

PMID:9354786 PMID:12376507 PMID:18809606 PMID:19924528 PMID:20176959 More...

NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:6,562,632...6,579,956

sigmoid neoplasm

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

APC regulator of WNT signaling pathway

ClinVar Annotator: match by term: Sigmoid colon cancer

PMID:25741868 PMID:28492532

NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696

G

mutS homolog 2

ClinVar Annotator: match by term: Sigmoid colon cancer

PMID:10495924 PMID:12658575 PMID:15849733 PMID:17312306 PMID:18566915 More...

NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938

G

mutS homolog 6

ClinVar Annotator: match by term: Sigmoid colon cancer

PMID:9354786 PMID:12376507 PMID:18809606 PMID:19924528 PMID:20176959 More...

NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:6,562,632...6,579,956

Term paths to the root

Path 1
Term	Annotations
disease	19140
disease of anatomical entity	18453
gastrointestinal system disease	7196
intestinal disease	3105
rectal disease	2056
Colorectal Neoplasms	1794
Colonic Neoplasms	412
Colitis-Associated Neoplasms	5
colon cancer +	254
colonic benign neoplasm +	12
Path 2
Term	Annotations
disease	19140
disease of anatomical entity	18453
gastrointestinal system disease	7196
Digestive System Neoplasms	3852
Gastrointestinal Neoplasms	3729
Intestinal Neoplasms	1812
Colorectal Neoplasms	1794
Colonic Neoplasms	412
Colitis-Associated Neoplasms	5
colon cancer +	254
colonic benign neoplasm +	12

paths to the root