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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Multiple Organ Failure
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Accession:DOID:9002906 term browser browse the term
Definition:A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
Synonyms:exact_synonym: MODS;   MOFS;   Multiple Organ Dysfunction Syndrome;   Multiple Organ Failures;   multiple organ failure syndrome
 narrow_synonym: INFANT ONSET MULTIPLE ORGAN FAILURE
 primary_id: MESH:D009102;   RDO:0006148
 xref: EFO:1001373


show annotations for term's descendants           Sort by:
Multiple Organ Failure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15241586 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G C5ar1 complement C5a receptor 1 IMP associated with Aortic Aneurysm, Abdominal RGD PMID:14718840 RGD:5130167 NCBI chr 1:86,077,309...86,088,001 JBrowse link
G Ccl11 C-C motif chemokine ligand 11 ISO associated with Anthrax;protein:increased expression:serum RGD PMID:16251415 RGD:7248409 NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP protein:increased expression:serum, peritoneal fluid (rat) RGD PMID:15793719 RGD:8549633 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cpb2 carboxypeptidase B2 IMP associated with sepsis, endotoxemia; RGD PMID:19325462 RGD:7243114 NCBI chr15:56,967,128...57,015,964
Ensembl chr15:50,557,717...50,606,556 		JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 IMP associated with Kidney Failure, Chronic RGD PMID:17499745 RGD:4781453 NCBI chr  X:75,734,281...75,762,873
Ensembl chr  X:71,663,821...71,690,121 		JBrowse link
G Hmgb1 high mobility group box 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19265175 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO
IEP		 protein:increased expression:pancreas, intestine (mouse)
protein:increased secretion:serum (rat)		 RGD PMID:19819333 PMID:20646933 RGD:4145501, RGD:4145375 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il10 interleukin 10 ISO CTD Direct Evidence: therapeutic CTD PMID:10479408 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta IDA
ISO		 associated with Heat Stroke RGD PMID:21392091 PMID:21323892 RGD:7175322, RGD:7175326 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO associated with Wounds and Injuries;protein:increased expression:plasma RGD PMID:10670873 PMID:19241361 RGD:4143178, RGD:6907089 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Lbp lipopolysaccharide binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:22167001 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:146,954,015...146,981,586 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEP protein: increased expression: lung and liver RGD PMID:22392145 RGD:7244173 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO protein:increased activity:lung, spleen (mouse) RGD PMID:15259001 RGD:7207133 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp13 matrix metallopeptidase 13 ISO protein:increased activity:liver, lung, spleen (mouse) RGD PMID:15259001 RGD:7207133 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:increased activity:liver, spleen (mouse) RGD PMID:15259001 RGD:7207133 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO
IEP		 protein:increased activity:liver, lung, spleen (mouse)
protein:increased expression:multiple tissues
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15259001 PMID:15259001 PMID:21964536 RGD:7207133, RGD:8547897 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Plat plasminogen activator, tissue type IEP protein:increased expression:plasma (rat) RGD PMID:16977483 RGD:11081009 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha severity ISO associated with Drug Toxicity (CTD:0005347), Zymosan (CHEBI:37671); DNA:knockout::knockout increases severity (mouse) RGD PMID:17047518 RGD:5683625 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ptafr platelet-activating factor receptor treatment IMP associated with Pancreatitis, Experimental RGD PMID:9750012 RGD:10043149 NCBI chr 5:150,049,322...150,079,060
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
G Serpinc1 serpin family C member 1 disease_progression ISO associated with Disseminated Intravascular Coagulation RGD PMID:9630308 RGD:11035250 NCBI chr13:75,790,558...75,804,826
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Serpine1 serpin family E member 1 treatment IDA RGD PMID:16977483 RGD:11081009 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 ISO ClinVar Annotator: match by term: Infant onset multiple organ failure ClinVar NCBI chr18:53,546,263...53,614,478
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Sst somatostatin ISO CTD Direct Evidence: therapeutic CTD PMID:15834315 NCBI chr11:90,461,546...90,462,823
Ensembl chr11:76,956,896...76,958,173 		JBrowse link
G Tfam transcription factor A, mitochondrial ISO associated with Sepsis;protein:increased expression:skeletal muscle RGD PMID:18997871 RGD:6771188 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Thbd thrombomodulin treatment ISO associated with Endotoxemia RGD PMID:8665042 RGD:11038715 NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:135,862,835...135,867,193 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9696492 PMID:10890648 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Xdh xanthine dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:26968635 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19139
    Pathological Conditions, Signs and Symptoms 13625
      Pathologic Processes 8329
        Shock 419
          Multiple Organ Failure 28
paths to the root