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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Neointima
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Accession:DOID:9002514 term browser browse the term
Definition:The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.
Synonyms:exact_synonym: Neointima Formation;   Neointimas
 primary_id: MESH:D058426


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Neointima term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor treatment ISO RGD PMID:24132651 RGD:8695998 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:19258495 PMID:29609002 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO RGD PMID:25751394 RGD:329328927 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 treatment ISO RGD PMID:23535897 RGD:13782090 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Atp7a ATPase copper transporting alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:20671235 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Axl Axl receptor tyrosine kinase IEP RGD PMID:9758639 RGD:631894 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Becn1 beclin 1 IMP RGD PMID:25238224 RGD:11558011 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Carmn cardiac mesoderm enhancer-associated non-coding RNA exacerbates
ameliorates		 ISO
IDA		 RGD PMID:34694145 PMID:34694145 RGD:155883160, RGD:155883160 NCBI chr18:55,097,848...55,118,769
Ensembl chr18:55,095,230...55,118,825 		JBrowse link
G Clu clusterin ISO RGD PMID:19696405 PMID:20032585 RGD:8699512, RGD:9068412 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cybb cytochrome b-245 beta chain treatment IMP RGD PMID:20485380 RGD:11040762 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Drd4 dopamine receptor D4 treatment IDA associated with type 2 diabetes mellitus RGD PMID:24888351 RGD:13506962 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Ece1 endothelin converting enzyme 1 IEP mRNA:increased expression:carotid artery RGD PMID:8575076 RGD:7244170 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371 		JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 treatment ISO RGD PMID:18485080 RGD:9685444 NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317 		JBrowse link
G Epc1 enhancer of polycomb homolog 1 treatment ISO RGD PMID:22398275 RGD:9587795 NCBI chr17:54,503,358...54,594,444
Ensembl chr17:54,503,358...54,594,425 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 IEP RGD PMID:17438359 RGD:2289992 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G F3 coagulation factor III, tissue factor treatment IEP RGD PMID:22140576 RGD:11341672 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fgf2 fibroblast growth factor 2 IEP RGD PMID:8808969 RGD:8655643 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 IDA RGD PMID:15072997 RGD:10402089 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 treatment IEP
IMP		 mRNA,protein:increased expression:smooth muscle cell: RGD PMID:9400373 PMID:22814749 RGD:10402128, RGD:10402146 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Foxo4 forkhead box O4 ISO protein:increased expression:smooth muscle cell: RGD PMID:17242183 PMID:16054032 RGD:10402361, RGD:10402362 NCBI chr  X:66,385,241...66,392,115
Ensembl chr  X:66,385,558...66,392,115 		JBrowse link
G Gas6 growth arrest specific 6 IEP RGD PMID:9758639 RGD:631894 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Gata2 GATA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761 		JBrowse link
G Hmox1 heme oxygenase 1 treatment IMP RGD PMID:21804207 RGD:10755571 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO associated with Hypertension RGD PMID:12791939 RGD:1580477 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 ISO associated with Vascular System Injuries RGD PMID:23657573 RGD:11049552 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755 		JBrowse link
G Irf8 interferon regulatory factor 8 ameliorates ISO associated with Carotid Artery Injuries RGD PMID:24248596 RGD:329902075 NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829 		JBrowse link
G Klf5 KLF transcription factor 5 IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16224062 PMID:10417400 RGD:1581746 NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445 		JBrowse link
G Lgals3 galectin 3 IEP mRNA:increased expression:thoracic aorta RGD PMID:9688561 RGD:9685205 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 treatment IMP RGD PMID:14638553 RGD:10412321 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mir125a microRNA 125a treatment IMP RGD PMID:30156956 RGD:26884369 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710 		JBrowse link
G Mir126b microRNA 126b ameliorates IDA RGD PMID:31964421 RGD:401850783 NCBI chr 3:9,415,087...9,415,159 JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment ISO
IEP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17964422 PMID:23344254 RGD:13207403 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO
IEP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17964422 PMID:23344254 RGD:13207403 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myb MYB proto-oncogene, transcription factor treatment IMP RGD PMID:10438864 RGD:11532744 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 IMP RGD PMID:22508052 RGD:11073699 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320 		JBrowse link
G Nrg1 neuregulin 1 IEP RGD PMID:17438359 RGD:2289992 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 IDA
IMP		 RGD PMID:22922962 PMID:19359598 RGD:10041068, RGD:11533945 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 IMP RGD PMID:15044192 RGD:10413907 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdgfb platelet derived growth factor subunit B IEP RGD PMID:8585266 RGD:10449489 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha treatment IEP associated with Carotid Artery Injuries RGD PMID:9323080 RGD:11087557 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta treatment IEP associated with Carotid Artery Injuries RGD PMID:9323080 RGD:11087557 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISO RGD PMID:20307651 RGD:8693429 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785 		JBrowse link
G Pkn1 protein kinase N1 ameliorates IMP RGD PMID:22893700 RGD:243065233 NCBI chr19:24,442,130...24,470,107
Ensembl chr19:24,442,122...24,470,107 		JBrowse link
G Poldip2 DNA polymerase delta interacting protein 2 ISO RGD PMID:30237457 RGD:124713557 NCBI chr10:63,407,237...63,417,605
Ensembl chr10:63,407,213...63,417,605 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP associated with Carotid Artery Injuries RGD PMID:22922962 RGD:10041068 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C treatment IEP associated with Diabetes Mellitus, Type 2 RGD PMID:12377736 RGD:729766 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29609002 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G Selp selectin P treatment IMP associated with Diabetes Mellitus, Type 2 RGD PMID:12377736 RGD:729766 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Senp1 SUMO specific peptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 7:129,163,173...129,226,766
Ensembl chr 7:129,165,774...129,221,598 		JBrowse link
G Serpine1 serpin family E member 1 treatment IMP
ISO		 associated with Diabetes Mellitus, Type 2
human protein in rat model		 RGD PMID:18091579 PMID:19574558 RGD:8547879, RGD:8547913 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Spon2 spondin 2 ISO
IMP		 RGD PMID:25751394 PMID:25751394 RGD:329328927, RGD:329328927 NCBI chr14:77,505,695...77,518,001
Ensembl chr14:77,511,901...77,517,996 		JBrowse link
G Spon2em1Holi spondin 2; TALEN induced mutant1, Holi IMP RGD PMID:25751394 RGD:329328927
G Ssh1 slingshot protein phosphatase 1 IEP protein:increased expression:carotid artery RGD PMID:21868701 RGD:11535005 NCBI chr12:42,621,127...42,683,262
Ensembl chr12:42,621,135...42,683,274 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 treatment IDA associated with Carotid Artery Injuries RGD PMID:16118253 RGD:5509614 NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stim1 stromal interaction molecule 1 ameliorates IMP RGD PMID:19107116 RGD:151893459 NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363 		JBrowse link
G Tfpi tissue factor pathway inhibitor treatment ISO
IEP		 RGD PMID:10521388 PMID:22140576 RGD:11060274, RGD:11341672 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880 		JBrowse link
G Timm44 translocase of inner mitochondrial membrane 44 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:16186389 RGD:13463598 NCBI chr12:2,612,581...2,629,374
Ensembl chr12:2,612,581...2,629,351 		JBrowse link
G Yy1 YY1 transcription factor treatment IMP RGD PMID:21030713 RGD:9588268 NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19050
    Pathological Conditions, Signs and Symptoms 13532
      Pathologic Processes 8240
        Neointima 59
Path 2
Term Annotations click to browse term
  disease 19050
    Pathological Conditions, Signs and Symptoms 13532
      Pathologic Processes 8240
        Hyperplasia 139
          Intimal Hyperplasia 78
            Neointima 59
paths to the root